ST13P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synapse maturation (GO:0090129)8.20627229
2regulation of vascular endothelial growth factor signaling pathway (GO:1900746)7.79810866
3regulation of synapse maturation (GO:0090128)6.99318906
4single strand break repair (GO:0000012)6.90612519
5regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)6.64532874
6L-fucose catabolic process (GO:0042355)6.56467427
7fucose catabolic process (GO:0019317)6.56467427
8L-fucose metabolic process (GO:0042354)6.56467427
9regulation of G0 to G1 transition (GO:0070316)6.38231524
10negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)6.29367834
11negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)6.28862538
12cell wall macromolecule catabolic process (GO:0016998)5.43948865
13layer formation in cerebral cortex (GO:0021819)5.35024263
14protein targeting to lysosome (GO:0006622)5.25441444
15establishment of protein localization to vacuole (GO:0072666)5.25441444
16protein targeting to vacuole (GO:0006623)5.25441444
17negative regulation of heart rate (GO:0010459)5.18739458
18cell wall macromolecule metabolic process (GO:0044036)5.06009335
19regulation of cilium movement (GO:0003352)5.02669059
20negative regulation of catenin import into nucleus (GO:0035414)5.02029335
21regulation of p38MAPK cascade (GO:1900744)4.85720075
22cAMP catabolic process (GO:0006198)4.74571849
23central nervous system projection neuron axonogenesis (GO:0021952)4.48552314
24regulation of sarcomere organization (GO:0060297)4.48255501
25negative regulation of transcription regulatory region DNA binding (GO:2000678)4.45617810
26activation of MAPKKK activity (GO:0000185)4.38778281
27negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.34899187
28negative regulation of Ras GTPase activity (GO:0034261)4.32145032
29regulation of skeletal muscle contraction (GO:0014819)4.28318226
30myoblast migration (GO:0051451)4.22231538
31cyclic nucleotide catabolic process (GO:0009214)4.20723229
32sphingomyelin metabolic process (GO:0006684)4.08585045
33TOR signaling (GO:0031929)4.03916501
34pericardium development (GO:0060039)4.03639507
35regulation of mesoderm development (GO:2000380)3.94655316
36protein localization to vacuole (GO:0072665)3.94402838
37protein localization to lysosome (GO:0061462)3.94402838
38retinal cone cell development (GO:0046549)3.93601802
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.91331639
40sterol catabolic process (GO:0016127)3.76831438
41cholesterol catabolic process (GO:0006707)3.76831438
42peptidyl-lysine dimethylation (GO:0018027)3.68213661
43cellular protein catabolic process (GO:0044257)3.67306758
44histone H3-K9 methylation (GO:0051567)3.59514167
45endoderm formation (GO:0001706)3.59141111
46SMAD protein complex assembly (GO:0007183)3.59067860
47pancreas development (GO:0031016)3.56125702
48regulation of cell communication by electrical coupling (GO:0010649)3.53222609
49cellular potassium ion homeostasis (GO:0030007)3.48246074
50oxidative demethylation (GO:0070989)3.47753116
51central nervous system neuron axonogenesis (GO:0021955)3.42316120
52gamma-aminobutyric acid transport (GO:0015812)3.41616032
53regulation of microtubule-based movement (GO:0060632)3.40703187
54homocysteine metabolic process (GO:0050667)3.40080163
55plasma membrane repair (GO:0001778)3.34447099
56regulation of relaxation of muscle (GO:1901077)3.31801942
57negative regulation of ERK1 and ERK2 cascade (GO:0070373)3.26255983
58negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.25138649
59I-kappaB phosphorylation (GO:0007252)3.24959848
60regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.23405733
61negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.21354596
62positive regulation of dendritic spine morphogenesis (GO:0061003)3.20055224
63steroid catabolic process (GO:0006706)3.17598245
64activation of protein kinase B activity (GO:0032148)3.16923949
65S-adenosylmethionine metabolic process (GO:0046500)3.16319785
66negative regulation of protein localization to cell surface (GO:2000009)3.07979432
67regulation of integrin-mediated signaling pathway (GO:2001044)3.05354870
68ribonucleoprotein complex disassembly (GO:0032988)2.99994021
69fucosylation (GO:0036065)2.98300843
70positive regulation of focal adhesion assembly (GO:0051894)2.96461664
71positive regulation of cell junction assembly (GO:1901890)2.96461664
72histone H3-K9 modification (GO:0061647)2.93430722
73regulation of cardiac muscle cell contraction (GO:0086004)2.92842959
74glyoxylate metabolic process (GO:0046487)2.89414760
75regulation of fibroblast migration (GO:0010762)2.87370162
76regulation of action potential (GO:0098900)2.84546815
77organ growth (GO:0035265)2.80472528
78limb bud formation (GO:0060174)2.78052253
79negative regulation of potassium ion transmembrane transport (GO:1901380)2.76033382
80regulation of transcription regulatory region DNA binding (GO:2000677)2.73176860
81negative regulation of DNA binding (GO:0043392)2.72970378
82fucose metabolic process (GO:0006004)2.72568477
83DNA deamination (GO:0045006)2.66426823
84regulation of germinal center formation (GO:0002634)2.66189573
85regulation of membrane repolarization (GO:0060306)2.65616866
86prenylation (GO:0097354)2.65150954
87protein prenylation (GO:0018342)2.65150954
88negative regulation of endothelial cell migration (GO:0010596)2.62157643
89cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.60625403
90positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.59799010
91regulation of sequestering of triglyceride (GO:0010889)2.58439880
92positive regulation of microtubule polymerization (GO:0031116)2.58046745
93positive regulation of adherens junction organization (GO:1903393)2.57610986
94positive regulation of cardiac muscle cell differentiation (GO:2000727)2.56875499
95embryonic foregut morphogenesis (GO:0048617)2.56007556
96behavioral response to nicotine (GO:0035095)2.55587559
97sequestering of metal ion (GO:0051238)2.54746612
98signal transduction involved in regulation of gene expression (GO:0023019)2.53824364
99negative regulation of cardiac muscle tissue growth (GO:0055022)2.53223876
100negative regulation of heart growth (GO:0061117)2.53223876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.10409127
2EZH2_22144423_ChIP-Seq_EOC_Human2.86625072
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69468512
4ZNF274_21170338_ChIP-Seq_K562_Hela2.68842914
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.65699576
6IGF1R_20145208_ChIP-Seq_DFB_Human2.59466539
7GBX2_23144817_ChIP-Seq_PC3_Human2.50887811
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43702257
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.19228993
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15382060
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12683956
12FUS_26573619_Chip-Seq_HEK293_Human1.99530578
13BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98137486
14GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.95115546
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91214903
16TAF15_26573619_Chip-Seq_HEK293_Human1.90378325
17PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86736992
18EWS_26573619_Chip-Seq_HEK293_Human1.85433510
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84754716
20LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81281081
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78766710
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.77707720
23P300_19829295_ChIP-Seq_ESCs_Human1.74968456
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74743917
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70525178
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.70421994
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69826913
28CBP_20019798_ChIP-Seq_JUKART_Human1.67747316
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67747316
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67212542
31BCAT_22108803_ChIP-Seq_LS180_Human1.62756074
32ER_23166858_ChIP-Seq_MCF-7_Human1.61848191
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61367135
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60784124
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60094716
36REST_21632747_ChIP-Seq_MESCs_Mouse1.57633371
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56362045
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.53747638
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.52741160
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.50942207
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49720094
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49267148
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.48176843
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47773047
45IRF1_19129219_ChIP-ChIP_H3396_Human1.47458875
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.47198968
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46103311
48TCF4_23295773_ChIP-Seq_U87_Human1.45628355
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.43330555
50SMAD4_21799915_ChIP-Seq_A2780_Human1.42815653
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.42317187
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42265981
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41963942
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40142260
55STAT3_23295773_ChIP-Seq_U87_Human1.39005341
56P53_22387025_ChIP-Seq_ESCs_Mouse1.38429992
57RNF2_27304074_Chip-Seq_NSC_Mouse1.36300383
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35882901
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35378545
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35254069
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.34730277
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34536159
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34536159
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32661933
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.27537284
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.27166845
67LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26980466
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.25847050
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.25446583
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25349655
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23951933
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21765956
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.20925623
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20592808
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19627549
76FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18802746
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18187889
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.16973621
79EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15140009
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.14059027
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13308882
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13192687
83NANOG_19829295_ChIP-Seq_ESCs_Human1.12666986
84SOX2_19829295_ChIP-Seq_ESCs_Human1.12666986
85TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10700450
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10116569
87CRX_20693478_ChIP-Seq_RETINA_Mouse1.10057229
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.09477387
89MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08993280
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08106055
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07239686
92SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06964447
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.06443525
94RUNX2_22187159_ChIP-Seq_PCA_Human1.06386818
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.06048596
96NCOR_22424771_ChIP-Seq_293T_Human1.05448706
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05077082
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04416340
99FLI1_21867929_ChIP-Seq_TH2_Mouse1.02898864
100REST_18959480_ChIP-ChIP_MESCs_Mouse1.01681331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium5.29590272
2MP0003787_abnormal_imprinting5.12030002
3MP0005499_abnormal_olfactory_system4.36883917
4MP0005394_taste/olfaction_phenotype4.36883917
5MP0009053_abnormal_anal_canal4.05131447
6MP0002735_abnormal_chemical_nociception4.01473736
7MP0009840_abnormal_foam_cell3.66769165
8MP0004885_abnormal_endolymph2.74471012
9MP0001440_abnormal_grooming_behavior2.44447134
10MP0005367_renal/urinary_system_phenotyp2.34963099
11MP0000516_abnormal_urinary_system2.34963099
12MP0002138_abnormal_hepatobiliary_system2.19781900
13MP0001299_abnormal_eye_distance/2.07315270
14MP0002837_dystrophic_cardiac_calcinosis2.00203208
15MP0004924_abnormal_behavior1.98717587
16MP0005386_behavior/neurological_phenoty1.98717587
17MP0003121_genomic_imprinting1.81146785
18MP0003195_calcinosis1.78830854
19MP0002139_abnormal_hepatobiliary_system1.70248438
20MP0006292_abnormal_olfactory_placode1.65861755
21MP0004145_abnormal_muscle_electrophysio1.64137779
22MP0009745_abnormal_behavioral_response1.53641535
23MP0000778_abnormal_nervous_system1.51469189
24MP0004142_abnormal_muscle_tone1.51185005
25MP0003950_abnormal_plasma_membrane1.48590529
26MP0005423_abnormal_somatic_nervous1.45189095
27MP0000955_abnormal_spinal_cord1.44782754
28MP0000569_abnormal_digit_pigmentation1.43983256
29MP0002102_abnormal_ear_morphology1.42340119
30MP0009250_abnormal_appendicular_skeleto1.42207021
31MP0003890_abnormal_embryonic-extraembry1.41697236
32MP0001485_abnormal_pinna_reflex1.37759809
33MP0002272_abnormal_nervous_system1.34678369
34MP0009046_muscle_twitch1.34152939
35MP0005379_endocrine/exocrine_gland_phen1.34052699
36MP0008875_abnormal_xenobiotic_pharmacok1.34050434
37MP0005377_hearing/vestibular/ear_phenot1.28645605
38MP0003878_abnormal_ear_physiology1.28645605
39MP0001188_hyperpigmentation1.27317004
40MP0000372_irregular_coat_pigmentation1.25570546
41MP0003136_yellow_coat_color1.25380744
42MP0004270_analgesia1.25364300
43MP0000049_abnormal_middle_ear1.24556847
44MP0000534_abnormal_ureter_morphology1.24383109
45MP0001486_abnormal_startle_reflex1.23911051
46MP0002233_abnormal_nose_morphology1.23774348
47MP0005195_abnormal_posterior_eye1.20672729
48MP0003786_premature_aging1.16134051
49MP0005360_urolithiasis1.14083969
50MP0003879_abnormal_hair_cell1.13945481
51MP0004859_abnormal_synaptic_plasticity1.13819848
52MP0002733_abnormal_thermal_nociception1.11931933
53MP0003868_abnormal_feces_composition1.10959867
54MP0001764_abnormal_homeostasis1.10866972
55MP0003633_abnormal_nervous_system1.10574267
56MP0005551_abnormal_eye_electrophysiolog1.09474695
57MP0002163_abnormal_gland_morphology1.08163683
58MP0005646_abnormal_pituitary_gland1.07084452
59MP0005187_abnormal_penis_morphology1.06632485
60MP0008058_abnormal_DNA_repair1.06242337
61MP0005645_abnormal_hypothalamus_physiol1.05439662
62MP0003635_abnormal_synaptic_transmissio1.04206698
63MP0004147_increased_porphyrin_level1.04047923
64MP0005220_abnormal_exocrine_pancreas1.03320193
65MP0010329_abnormal_lipoprotein_level1.02761136
66MP0008872_abnormal_physiological_respon1.02173340
67MP0002184_abnormal_innervation1.01895781
68MP0002067_abnormal_sensory_capabilities0.95555598
69MP0003567_abnormal_fetal_cardiomyocyte0.95147328
70MP0002229_neurodegeneration0.95120379
71MP0009697_abnormal_copulation0.92201490
72MP0001348_abnormal_lacrimal_gland0.86458306
73MP0002572_abnormal_emotion/affect_behav0.85546660
74MP0002752_abnormal_somatic_nervous0.85334049
75MP0002064_seizures0.82179808
76MP0000470_abnormal_stomach_morphology0.81303736
77MP0004215_abnormal_myocardial_fiber0.80541767
78MP0003631_nervous_system_phenotype0.80305266
79MP0006072_abnormal_retinal_apoptosis0.78973307
80MP0001501_abnormal_sleep_pattern0.78662335
81MP0002734_abnormal_mechanical_nocicepti0.76248784
82MP0002557_abnormal_social/conspecific_i0.75200950
83MP0001970_abnormal_pain_threshold0.74971183
84MP0004811_abnormal_neuron_physiology0.74562541
85MP0003119_abnormal_digestive_system0.74218552
86MP0005451_abnormal_body_composition0.74151599
87MP0002882_abnormal_neuron_morphology0.73837709
88MP0001968_abnormal_touch/_nociception0.73796425
89MP0005085_abnormal_gallbladder_physiolo0.73792806
90MP0010386_abnormal_urinary_bladder0.72999357
91MP0002063_abnormal_learning/memory/cond0.72089208
92MP0000631_abnormal_neuroendocrine_gland0.71865175
93MP0000749_muscle_degeneration0.69329544
94MP0002736_abnormal_nociception_after0.68811292
95MP0001293_anophthalmia0.68551229
96MP0008877_abnormal_DNA_methylation0.68033354
97MP0003252_abnormal_bile_duct0.65285681
98MP0008995_early_reproductive_senescence0.60526432
99MP0001765_abnormal_ion_homeostasis0.60415735
100MP0004133_heterotaxia0.59984376

Predicted human phenotypes

RankGene SetZ-score
1Hyperlipoproteinemia (HP:0010980)8.20795787
2Hypoalphalipoproteinemia (HP:0003233)6.17562494
3Action tremor (HP:0002345)4.77901988
4Xanthomatosis (HP:0000991)4.22185600
5Congenital, generalized hypertrichosis (HP:0004540)3.72965158
6Prolonged neonatal jaundice (HP:0006579)3.69335107
7Febrile seizures (HP:0002373)3.64642758
8Choroideremia (HP:0001139)3.51171078
9Autoamputation (HP:0001218)3.41646721
10Short chin (HP:0000331)3.40513855
11Abnormality of the left ventricular outflow tract (HP:0011103)3.29003543
12Subaortic stenosis (HP:0001682)3.29003543
13Hypolipoproteinemia (HP:0010981)3.27649207
14Alveolar cell carcinoma (HP:0006519)3.20790766
15Polyphagia (HP:0002591)3.17221143
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.09886430
17Athetosis (HP:0002305)3.06711476
18Metaphyseal dysplasia (HP:0100255)3.06605989
19Small hand (HP:0200055)2.97211992
20Neoplasm of the tracheobronchial system (HP:0100552)2.97132870
21Calf muscle hypertrophy (HP:0008981)2.96112888
22Bulbous nose (HP:0000414)2.93513093
23Protuberant abdomen (HP:0001538)2.92946021
24Pancreatic fibrosis (HP:0100732)2.84830156
25Fibular aplasia (HP:0002990)2.74746982
26Thyroiditis (HP:0100646)2.67482140
27Muscle hypertrophy of the lower extremities (HP:0008968)2.58135270
28Abnormality of DNA repair (HP:0003254)2.52180969
29Congenital stationary night blindness (HP:0007642)2.45814256
30Occipital encephalocele (HP:0002085)2.44694066
31Short hallux (HP:0010109)2.43027269
32Short 1st metacarpal (HP:0010034)2.40805691
33Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.40805691
34Exercise-induced muscle cramps (HP:0003710)2.39241456
35Delayed CNS myelination (HP:0002188)2.38532496
36Entropion (HP:0000621)2.36084188
37Abnormality of the proximal phalanges of the hand (HP:0009834)2.34827465
38Severe combined immunodeficiency (HP:0004430)2.34033554
39Limb dystonia (HP:0002451)2.33173367
40Bell-shaped thorax (HP:0001591)2.32061349
41Abnormality of the middle phalanges of the toes (HP:0010183)2.29043528
42Submucous cleft hard palate (HP:0000176)2.28127852
43Constricted visual fields (HP:0001133)2.27120415
44Renal cortical cysts (HP:0000803)2.25764907
45Tented upper lip vermilion (HP:0010804)2.22496026
46Aplasia/Hypoplasia of the hallux (HP:0008362)2.20885429
47Abnormality of the renal cortex (HP:0011035)2.19401216
48Abnormal rod and cone electroretinograms (HP:0008323)2.19371560
49Myotonia (HP:0002486)2.17538449
50Hypoplastic pelvis (HP:0008839)2.17205486
51Abnormality of the 1st metacarpal (HP:0010009)2.12666783
52Aplasia/hypoplasia of the uterus (HP:0008684)2.12289256
53Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09674383
542-3 toe syndactyly (HP:0004691)2.07927903
55Hypoplasia of the thymus (HP:0000778)2.05166162
56Inability to walk (HP:0002540)2.03168054
57Intention tremor (HP:0002080)2.03140246
58Abolished electroretinogram (ERG) (HP:0000550)2.02988105
59Anhidrosis (HP:0000970)2.02064276
60Pancreatic cysts (HP:0001737)2.00810275
61Aplasia/Hypoplasia of the spleen (HP:0010451)2.00680681
62Progressive visual loss (HP:0000529)1.98963260
63Brittle hair (HP:0002299)1.98871493
64Oligodontia (HP:0000677)1.95204796
65Asplenia (HP:0001746)1.94145522
66Anophthalmia (HP:0000528)1.91744396
67Stereotypic behavior (HP:0000733)1.91666858
68Nonprogressive disorder (HP:0003680)1.88702759
69Microcytic anemia (HP:0001935)1.88247043
70Abnormality of homocysteine metabolism (HP:0010919)1.87827203
71Homocystinuria (HP:0002156)1.87827203
72Genetic anticipation (HP:0003743)1.86471124
73Median cleft lip (HP:0000161)1.85654660
74Abnormal eating behavior (HP:0100738)1.83062408
75Short tibia (HP:0005736)1.82675041
76Symphalangism affecting the phalanges of the hand (HP:0009773)1.81681560
77Stenosis of the external auditory canal (HP:0000402)1.80473465
78Abnormality of midbrain morphology (HP:0002418)1.80127162
79Molar tooth sign on MRI (HP:0002419)1.80127162
80Septo-optic dysplasia (HP:0100842)1.79976961
81Progressive cerebellar ataxia (HP:0002073)1.79914992
82Colon cancer (HP:0003003)1.79247321
83Aplasia/Hypoplasia of the tibia (HP:0005772)1.78944331
84Pseudobulbar signs (HP:0002200)1.75778267
85Mild short stature (HP:0003502)1.75680559
86Cupped ear (HP:0000378)1.74955139
87Hypoplasia of the uterus (HP:0000013)1.73805501
88Medial flaring of the eyebrow (HP:0010747)1.72624415
89True hermaphroditism (HP:0010459)1.67616957
90Bile duct proliferation (HP:0001408)1.65759425
91Abnormal biliary tract physiology (HP:0012439)1.65759425
92Hip contracture (HP:0003273)1.65227133
93Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65049055
94Diplopia (HP:0000651)1.65044469
95Abnormality of binocular vision (HP:0011514)1.65044469
96Thyroid-stimulating hormone excess (HP:0002925)1.64865861
97Fatigable weakness (HP:0003473)1.62693425
98Abnormality of the neuromuscular junction (HP:0003398)1.62693425
99Abnormality of macrophages (HP:0004311)1.60065626
100Congenital hepatic fibrosis (HP:0002612)1.58461487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.43259871
2NTRK25.31329474
3BMPR1B4.31625554
4TLK13.09486935
5AKT33.06850093
6TGFBR12.27355728
7FRK2.22456082
8PINK12.02325125
9RIPK110.2624082
10LMTK21.83698099
11EIF2AK31.82087383
12MELK1.72496820
13STK161.57857609
14PHKG21.57405401
15PHKG11.57405401
16TNIK1.49297540
17NUAK11.48583721
18MUSK1.33871218
19TIE11.14607956
20WNK31.11437634
21MARK11.10438530
22STK391.05655583
23WNK41.01592301
24GRK11.00072429
25OXSR10.89302764
26FLT30.82643658
27MAPKAPK50.80685880
28PKN20.74873888
29NTRK30.72424483
30CDK80.67995496
31ADRBK20.65942825
32EIF2AK20.63642486
33CCNB10.62432554
34MAPK130.61612087
35CASK0.61039888
36DMPK0.58380076
37CAMK2A0.57224961
38TAOK10.52168191
39PRKCG0.52149163
40MARK20.45760483
41CAMKK20.44602066
42RPS6KB20.43529227
43MAPKAPK30.43181755
44MAP3K50.42992312
45PTK2B0.42724633
46MAP3K70.42299900
47BRAF0.40579019
48TXK0.38713196
49SGK20.38611683
50CSNK1G20.37041288
51ADRBK10.36676189
52MAP2K10.34175958
53EPHA40.34163603
54INSR0.33395503
55PRKCE0.31805077
56EIF2AK10.31644392
57IGF1R0.28983622
58PIK3CA0.28373878
59KIT0.28332544
60PRKG10.28273388
61SGK10.26717397
62PIK3CG0.25623092
63INSRR0.25301748
64DAPK20.25111570
65CDK30.25100135
66DYRK30.24431640
67RPS6KB10.23941692
68PRKACA0.23814294
69CSNK1A10.23401004
70CAMK2D0.23349207
71CHEK20.23275594
72PRKCQ0.22958832
73MAP4K20.22180610
74PRKACB0.22026202
75CDK190.21506996
76CDK90.21051720
77NEK20.19625295
78DYRK20.19392269
79MAPK70.18530155
80NME10.18396464
81MATK0.17598767
82CSNK1G30.16496649
83MAP3K110.15876504
84SGK2230.15587849
85SGK4940.15587849
86GRK50.15057636
87IKBKB0.14972245
88CSNK1D0.14310645
89ERBB30.13642912
90ABL10.13428192
91CAMK2B0.13400908
92NTRK10.13323928
93PLK10.13116711
94MAP3K40.13065309
95PRKCA0.12713324
96RPS6KA30.12672965
97CSNK1E0.12142073
98PLK20.12067986
99MAPK140.11706341
100MAPK120.11610022

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.45369372
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.36235558
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.01786696
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65976358
5Nicotine addiction_Homo sapiens_hsa050332.38762581
6Tryptophan metabolism_Homo sapiens_hsa003802.28458941
7Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.17822308
8Sphingolipid metabolism_Homo sapiens_hsa006002.11748850
9Protein export_Homo sapiens_hsa030602.06536448
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06460462
11Sulfur metabolism_Homo sapiens_hsa009202.04057363
12Linoleic acid metabolism_Homo sapiens_hsa005912.03987596
13Morphine addiction_Homo sapiens_hsa050321.92371369
14Sulfur relay system_Homo sapiens_hsa041221.84954403
15One carbon pool by folate_Homo sapiens_hsa006701.83310053
16Chemical carcinogenesis_Homo sapiens_hsa052041.69789880
17Retinol metabolism_Homo sapiens_hsa008301.65114854
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63749902
19Histidine metabolism_Homo sapiens_hsa003401.62999262
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.60180444
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.60018236
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.58048167
23Circadian rhythm_Homo sapiens_hsa047101.51379450
24ABC transporters_Homo sapiens_hsa020101.40431543
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31439619
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30997516
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.29807300
28Serotonergic synapse_Homo sapiens_hsa047261.25418935
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24498630
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.24284388
31Selenocompound metabolism_Homo sapiens_hsa004501.22288902
32Cardiac muscle contraction_Homo sapiens_hsa042601.20979911
33beta-Alanine metabolism_Homo sapiens_hsa004101.20034336
34Parkinsons disease_Homo sapiens_hsa050121.16467547
35Propanoate metabolism_Homo sapiens_hsa006401.16350151
36Oxidative phosphorylation_Homo sapiens_hsa001901.13899313
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.12430048
38Phototransduction_Homo sapiens_hsa047441.11394749
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04749938
40Lysine degradation_Homo sapiens_hsa003101.03756745
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03607441
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02325136
43Non-homologous end-joining_Homo sapiens_hsa034501.01889883
44Peroxisome_Homo sapiens_hsa041461.00519873
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.97516437
46Renin secretion_Homo sapiens_hsa049240.92141800
47Basal transcription factors_Homo sapiens_hsa030220.90021763
48Pyruvate metabolism_Homo sapiens_hsa006200.88523038
49Insulin secretion_Homo sapiens_hsa049110.88102624
50Oxytocin signaling pathway_Homo sapiens_hsa049210.87525484
51Bile secretion_Homo sapiens_hsa049760.85394922
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84423739
53Olfactory transduction_Homo sapiens_hsa047400.78125958
54GABAergic synapse_Homo sapiens_hsa047270.77620937
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76639549
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76470913
57Circadian entrainment_Homo sapiens_hsa047130.75213119
58Alzheimers disease_Homo sapiens_hsa050100.73948885
59Glycerolipid metabolism_Homo sapiens_hsa005610.73133056
60Taste transduction_Homo sapiens_hsa047420.72621709
61Glutamatergic synapse_Homo sapiens_hsa047240.70211599
62Homologous recombination_Homo sapiens_hsa034400.67093743
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65805750
64Fatty acid biosynthesis_Homo sapiens_hsa000610.64733717
65Fat digestion and absorption_Homo sapiens_hsa049750.64095263
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62673417
67Ether lipid metabolism_Homo sapiens_hsa005650.62158519
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61956417
69Intestinal immune network for IgA production_Homo sapiens_hsa046720.61818560
70Other glycan degradation_Homo sapiens_hsa005110.61207049
71Dorso-ventral axis formation_Homo sapiens_hsa043200.60876659
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60582459
73RNA degradation_Homo sapiens_hsa030180.59856768
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58082756
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56165977
76Pancreatic secretion_Homo sapiens_hsa049720.55954936
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55484091
78Purine metabolism_Homo sapiens_hsa002300.55012436
79TGF-beta signaling pathway_Homo sapiens_hsa043500.54053277
80Butanoate metabolism_Homo sapiens_hsa006500.54032385
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53871974
82cAMP signaling pathway_Homo sapiens_hsa040240.53670396
83Dopaminergic synapse_Homo sapiens_hsa047280.53535127
84Fatty acid degradation_Homo sapiens_hsa000710.53286419
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51461461
86Fanconi anemia pathway_Homo sapiens_hsa034600.49975962
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49840263
88Folate biosynthesis_Homo sapiens_hsa007900.49540009
89Salivary secretion_Homo sapiens_hsa049700.48837553
90Starch and sucrose metabolism_Homo sapiens_hsa005000.48817684
91Long-term depression_Homo sapiens_hsa047300.48669812
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.45698101
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44692011
94Asthma_Homo sapiens_hsa053100.40706604
95Huntingtons disease_Homo sapiens_hsa050160.40638901
96Metabolic pathways_Homo sapiens_hsa011000.39551933
97Complement and coagulation cascades_Homo sapiens_hsa046100.38050764
98Calcium signaling pathway_Homo sapiens_hsa040200.36225755
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36112061
100RNA polymerase_Homo sapiens_hsa030200.35813679

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