ST13P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.91205667
2negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.41573358
3protein neddylation (GO:0045116)5.03345913
4NADH dehydrogenase complex assembly (GO:0010257)4.83601033
5mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.83601033
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.83601033
7regulation of retinoic acid receptor signaling pathway (GO:0048385)4.63545222
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.50051433
9ATP synthesis coupled proton transport (GO:0015986)4.50051433
10viral transcription (GO:0019083)4.39551581
11DNA deamination (GO:0045006)4.36662149
12translational termination (GO:0006415)4.33496490
13cell proliferation in forebrain (GO:0021846)4.30210819
14negative regulation of heart rate (GO:0010459)4.20173537
15cellular ketone body metabolic process (GO:0046950)4.10429240
16cellular response to interferon-beta (GO:0035458)4.08242223
17negative regulation of macrophage differentiation (GO:0045650)4.03141417
18positive regulation of protein homodimerization activity (GO:0090073)3.94643261
19negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.91952160
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.91776173
21ribosomal small subunit assembly (GO:0000028)3.89806210
22DNA demethylation (GO:0080111)3.87047206
23cotranslational protein targeting to membrane (GO:0006613)3.86531072
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.86174759
25protein targeting to ER (GO:0045047)3.83513718
26olfactory bulb development (GO:0021772)3.75619314
27translational elongation (GO:0006414)3.74951070
28base-excision repair, AP site formation (GO:0006285)3.73419450
29protein complex biogenesis (GO:0070271)3.73185833
30protein localization to endoplasmic reticulum (GO:0070972)3.70140318
31maturation of SSU-rRNA (GO:0030490)3.68966996
32establishment of protein localization to endoplasmic reticulum (GO:0072599)3.65483219
33neuronal action potential propagation (GO:0019227)3.64925858
34ketone body metabolic process (GO:1902224)3.63946876
35kynurenine metabolic process (GO:0070189)3.63578268
36indolalkylamine catabolic process (GO:0046218)3.57590149
37tryptophan catabolic process (GO:0006569)3.57590149
38indole-containing compound catabolic process (GO:0042436)3.57590149
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.54096389
40negative regulation of transcription regulatory region DNA binding (GO:2000678)3.52424216
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.44617921
42positive regulation of mitochondrial fission (GO:0090141)3.40486216
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.39686871
44oxidative demethylation (GO:0070989)3.39206035
45mitochondrial respiratory chain complex assembly (GO:0033108)3.36671614
46ribosomal small subunit biogenesis (GO:0042274)3.35804395
47spinal cord association neuron differentiation (GO:0021527)3.34459564
48respiratory electron transport chain (GO:0022904)3.25333913
49electron transport chain (GO:0022900)3.24289133
50cellular protein complex disassembly (GO:0043624)3.19127667
51negative regulation of cation channel activity (GO:2001258)3.16192591
52DNA dealkylation (GO:0035510)3.14015425
53pattern specification involved in kidney development (GO:0061004)3.11437167
54viral life cycle (GO:0019058)3.09523590
55regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.08548220
56response to redox state (GO:0051775)3.05472998
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03067408
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02006790
59negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.01808156
60negative regulation of calcium ion transmembrane transport (GO:1903170)3.01808156
61substrate-independent telencephalic tangential migration (GO:0021826)2.96923577
62substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.96923577
63ribonucleoprotein complex disassembly (GO:0032988)2.93355855
64exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92686328
65viral protein processing (GO:0019082)2.90786946
66fucose catabolic process (GO:0019317)2.88193060
67L-fucose metabolic process (GO:0042354)2.88193060
68L-fucose catabolic process (GO:0042355)2.88193060
69response to interferon-beta (GO:0035456)2.86937352
70forebrain neuron differentiation (GO:0021879)2.86702914
71behavioral response to ethanol (GO:0048149)2.86217543
72ribosomal large subunit biogenesis (GO:0042273)2.86184936
73translational initiation (GO:0006413)2.85204171
74pyrimidine dimer repair (GO:0006290)2.84869188
75pyrimidine nucleobase catabolic process (GO:0006208)2.84115403
76intraciliary transport (GO:0042073)2.78342689
77aromatic amino acid family catabolic process (GO:0009074)2.78283131
78negative regulation of mast cell activation (GO:0033004)2.77676403
79mast cell activation involved in immune response (GO:0002279)2.74978937
80mast cell degranulation (GO:0043303)2.74978937
81macromolecular complex disassembly (GO:0032984)2.73810414
82segment specification (GO:0007379)2.72949527
83establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.72924703
84mitochondrion transport along microtubule (GO:0047497)2.72924703
85appendage development (GO:0048736)2.72519734
86limb development (GO:0060173)2.72519734
87protein complex disassembly (GO:0043241)2.72318395
88single strand break repair (GO:0000012)2.72304545
89pyrimidine nucleotide catabolic process (GO:0006244)2.70925636
90negative regulation of granulocyte differentiation (GO:0030853)2.70425164
91positive regulation of cAMP-mediated signaling (GO:0043950)2.69546245
92protein import into peroxisome matrix (GO:0016558)2.69484827
93lysosome localization (GO:0032418)2.69192017
94regulation of cilium movement (GO:0003352)2.64985181
95protein targeting to membrane (GO:0006612)2.62553063
96establishment of mitochondrion localization (GO:0051654)2.59896314
97regulation of cellular respiration (GO:0043457)2.58612531
98transcription elongation from RNA polymerase III promoter (GO:0006385)2.57861247
99termination of RNA polymerase III transcription (GO:0006386)2.57861247
100synaptic transmission, cholinergic (GO:0007271)2.57698997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.07514473
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.33319056
3ZNF274_21170338_ChIP-Seq_K562_Hela3.12675337
4EZH2_22144423_ChIP-Seq_EOC_Human3.12523435
5VDR_22108803_ChIP-Seq_LS180_Human3.00634141
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.87465966
7IRF1_19129219_ChIP-ChIP_H3396_Human2.82051182
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.73029792
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21711139
10FUS_26573619_Chip-Seq_HEK293_Human2.09034908
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.06480566
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.02026256
13MYC_18940864_ChIP-ChIP_HL60_Human1.97941252
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97512531
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94900853
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.91956011
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90366916
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.72406685
19ELK1_19687146_ChIP-ChIP_HELA_Human1.60969281
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58998638
21VDR_23849224_ChIP-Seq_CD4+_Human1.58682963
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.57525135
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54883966
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53868148
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50476230
26RNF2_27304074_Chip-Seq_NSC_Mouse1.49443902
27GBX2_23144817_ChIP-Seq_PC3_Human1.48727105
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48120203
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44057456
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41104522
31CBP_20019798_ChIP-Seq_JUKART_Human1.40002312
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40002312
33ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39450333
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39433140
35ER_23166858_ChIP-Seq_MCF-7_Human1.37358105
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36901094
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.36899877
38SOX2_19829295_ChIP-Seq_ESCs_Human1.34931228
39NANOG_19829295_ChIP-Seq_ESCs_Human1.34931228
40CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.34688219
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.33530884
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.29340805
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28474787
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28086464
45EWS_26573619_Chip-Seq_HEK293_Human1.27864407
46TP53_22573176_ChIP-Seq_HFKS_Human1.25664201
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.25532469
48TAF2_19829295_ChIP-Seq_ESCs_Human1.25068087
49NCOR_22424771_ChIP-Seq_293T_Human1.24979306
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24863802
51REST_21632747_ChIP-Seq_MESCs_Mouse1.23220131
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.22365821
53TTF2_22483619_ChIP-Seq_HELA_Human1.22342315
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22024519
55TAF15_26573619_Chip-Seq_HEK293_Human1.21717292
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21614289
57P300_19829295_ChIP-Seq_ESCs_Human1.21125246
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18894415
59TCF4_22108803_ChIP-Seq_LS180_Human1.14140028
60IGF1R_20145208_ChIP-Seq_DFB_Human1.13987282
61HOXB7_26014856_ChIP-Seq_BT474_Human1.13391822
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12945354
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12945354
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11693603
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11551337
66ERA_21632823_ChIP-Seq_H3396_Human1.10804664
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10721742
68FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07936338
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07858022
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07185584
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05103585
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.04809533
73GABP_19822575_ChIP-Seq_HepG2_Human1.03511605
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02863138
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.01628982
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01603989
77GATA6_21074721_ChIP-Seq_CACO-2_Human1.00545568
78ETV1_20927104_ChIP-Seq_GIST48_Human1.00263361
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00065582
80EED_16625203_ChIP-ChIP_MESCs_Mouse1.00002065
81RBPJ_21746931_ChIP-Seq_IB4_Human0.99643990
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99149988
83JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99053037
84TAL1_26923725_Chip-Seq_HPCs_Mouse0.98185674
85AR_25329375_ChIP-Seq_VCAP_Human0.96424866
86NANOG_20526341_ChIP-Seq_ESCs_Human0.95983218
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94233547
88TDRD3_21172665_ChIP-Seq_MCF-7_Human0.93590495
89RUNX2_22187159_ChIP-Seq_PCA_Human0.92341080
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90913968
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90871316
92GATA3_26560356_Chip-Seq_TH2_Human0.90869995
93PHF8_20622853_ChIP-Seq_HELA_Human0.90475024
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89641101
95REST_18959480_ChIP-ChIP_MESCs_Mouse0.89588920
96SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.88770199
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88438286
98MYC_18555785_ChIP-Seq_MESCs_Mouse0.88341706
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.86707060
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86427069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.04761836
2MP0003806_abnormal_nucleotide_metabolis4.17899059
3MP0006292_abnormal_olfactory_placode4.13845737
4MP0009379_abnormal_foot_pigmentation4.06447843
5MP0000569_abnormal_digit_pigmentation3.84890296
6MP0008877_abnormal_DNA_methylation3.64188665
7MP0004145_abnormal_muscle_electrophysio3.34626345
8MP0002102_abnormal_ear_morphology3.05862340
9MP0003011_delayed_dark_adaptation3.05503536
10MP0004142_abnormal_muscle_tone2.57755966
11MP0005646_abnormal_pituitary_gland2.56581633
12MP0006072_abnormal_retinal_apoptosis2.47903975
13MP0002837_dystrophic_cardiac_calcinosis2.34960069
14MP0001835_abnormal_antigen_presentation2.34338060
15MP0001188_hyperpigmentation2.16609171
16MP0003195_calcinosis2.08200312
17MP0003122_maternal_imprinting2.04426712
18MP0008789_abnormal_olfactory_epithelium2.00220662
19MP0003121_genomic_imprinting1.95272507
20MP0002822_catalepsy1.91104170
21MP0001529_abnormal_vocalization1.86870542
22MP0005671_abnormal_response_to1.79958403
23MP0001905_abnormal_dopamine_level1.78017696
24MP0000516_abnormal_urinary_system1.72484876
25MP0005367_renal/urinary_system_phenotyp1.72484876
26MP0005394_taste/olfaction_phenotype1.55977342
27MP0005499_abnormal_olfactory_system1.55977342
28MP0003646_muscle_fatigue1.50869542
29MP0003880_abnormal_central_pattern1.49149570
30MP0005174_abnormal_tail_pigmentation1.45331297
31MP0000778_abnormal_nervous_system1.44919312
32MP0005253_abnormal_eye_physiology1.42129576
33MP0004147_increased_porphyrin_level1.38641882
34MP0005645_abnormal_hypothalamus_physiol1.35570341
35MP0005551_abnormal_eye_electrophysiolog1.34806309
36MP0001986_abnormal_taste_sensitivity1.28854358
37MP0002653_abnormal_ependyma_morphology1.27741651
38MP0005084_abnormal_gallbladder_morpholo1.27689890
39MP0000631_abnormal_neuroendocrine_gland1.23747937
40MP0005386_behavior/neurological_phenoty1.23641327
41MP0004924_abnormal_behavior1.23641327
42MP0003123_paternal_imprinting1.22737529
43MP0009764_decreased_sensitivity_to1.19204131
44MP0009840_abnormal_foam_cell1.18129294
45MP0004043_abnormal_pH_regulation1.16842370
46MP0001984_abnormal_olfaction1.11117770
47MP0002735_abnormal_chemical_nociception1.09926844
48MP0009745_abnormal_behavioral_response1.05755282
49MP0008058_abnormal_DNA_repair1.05505570
50MP0002138_abnormal_hepatobiliary_system1.02562624
51MP0010386_abnormal_urinary_bladder1.02316058
52MP0005083_abnormal_biliary_tract1.00786429
53MP0009046_muscle_twitch1.00722384
54MP0009053_abnormal_anal_canal1.00128382
55MP0000049_abnormal_middle_ear0.98761929
56MP0001486_abnormal_startle_reflex0.97740357
57MP0003186_abnormal_redox_activity0.97690425
58MP0001968_abnormal_touch/_nociception0.97611468
59MP0001485_abnormal_pinna_reflex0.97503686
60MP0002638_abnormal_pupillary_reflex0.95714683
61MP0002006_tumorigenesis0.94923988
62MP0005647_abnormal_sex_gland0.91945375
63MP0004742_abnormal_vestibular_system0.91939447
64MP0006276_abnormal_autonomic_nervous0.89083610
65MP0001440_abnormal_grooming_behavior0.88691425
66MP0000639_abnormal_adrenal_gland0.88221944
67MP0002572_abnormal_emotion/affect_behav0.87404264
68MP0002876_abnormal_thyroid_physiology0.87061577
69MP0005195_abnormal_posterior_eye0.86164850
70MP0003878_abnormal_ear_physiology0.86029119
71MP0005377_hearing/vestibular/ear_phenot0.86029119
72MP0001970_abnormal_pain_threshold0.85093725
73MP0002095_abnormal_skin_pigmentation0.84964882
74MP0001502_abnormal_circadian_rhythm0.83064544
75MP0002272_abnormal_nervous_system0.82818832
76MP0003045_fibrosis0.82311534
77MP0005075_abnormal_melanosome_morpholog0.81777952
78MP0002009_preneoplasia0.80576420
79MP0005423_abnormal_somatic_nervous0.77719247
80MP0002557_abnormal_social/conspecific_i0.76714348
81MP0004215_abnormal_myocardial_fiber0.76670933
82MP0004885_abnormal_endolymph0.76479420
83MP0002752_abnormal_somatic_nervous0.74231989
84MP0001293_anophthalmia0.72676166
85MP0004019_abnormal_vitamin_homeostasis0.72611020
86MP0002734_abnormal_mechanical_nocicepti0.70869179
87MP0001800_abnormal_humoral_immune0.70463175
88MP0002938_white_spotting0.69791289
89MP0002166_altered_tumor_susceptibility0.69058330
90MP0002163_abnormal_gland_morphology0.68955702
91MP0000015_abnormal_ear_pigmentation0.66242313
92MP0005451_abnormal_body_composition0.66070483
93MP0000534_abnormal_ureter_morphology0.63327141
94MP0009765_abnormal_xenobiotic_induced0.62319705
95MP0002063_abnormal_learning/memory/cond0.59746833
96MP0001764_abnormal_homeostasis0.57729613
97MP0005085_abnormal_gallbladder_physiolo0.57338449
98MP0005391_vision/eye_phenotype0.57018141
99MP0002067_abnormal_sensory_capabilities0.56400754
100MP0003635_abnormal_synaptic_transmissio0.54715140

Predicted human phenotypes

RankGene SetZ-score
1Median cleft lip (HP:0000161)4.62810320
2Acute necrotizing encephalopathy (HP:0006965)4.58558240
33-Methylglutaconic aciduria (HP:0003535)4.19019500
4Abnormality of midbrain morphology (HP:0002418)4.03746130
5Molar tooth sign on MRI (HP:0002419)4.03746130
6Acute encephalopathy (HP:0006846)3.89438653
7Progressive macrocephaly (HP:0004481)3.83816842
8Abnormal mitochondria in muscle tissue (HP:0008316)3.82294225
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.71933540
10Mitochondrial inheritance (HP:0001427)3.61354889
11Pancreatic cysts (HP:0001737)3.50842093
12Submucous cleft hard palate (HP:0000176)3.40389946
13Pancreatic fibrosis (HP:0100732)3.34114519
14Increased CSF lactate (HP:0002490)3.32634506
15Agitation (HP:0000713)3.22656381
16Cerebral edema (HP:0002181)2.94017857
17Congenital, generalized hypertrichosis (HP:0004540)2.89652675
18Macrocytic anemia (HP:0001972)2.77624507
19Genetic anticipation (HP:0003743)2.77248447
20Nephronophthisis (HP:0000090)2.75245237
21Split foot (HP:0001839)2.74990994
22Thin bony cortex (HP:0002753)2.73639880
23Adrenal hypoplasia (HP:0000835)2.72173790
24Hyperventilation (HP:0002883)2.68379235
25Myotonia (HP:0002486)2.64790356
26Increased hepatocellular lipid droplets (HP:0006565)2.59494582
27Reticulocytopenia (HP:0001896)2.59208381
28Type I transferrin isoform profile (HP:0003642)2.51154262
29Abnormal rod and cone electroretinograms (HP:0008323)2.44295605
30Delayed epiphyseal ossification (HP:0002663)2.44266031
31Optic disc pallor (HP:0000543)2.42447413
32Thyroid-stimulating hormone excess (HP:0002925)2.41313870
33True hermaphroditism (HP:0010459)2.36489957
34Lactic acidosis (HP:0003128)2.34923072
35Hepatocellular necrosis (HP:0001404)2.33180292
36Exertional dyspnea (HP:0002875)2.32951879
37Abnormality of the corticospinal tract (HP:0002492)2.30382366
38Cystic liver disease (HP:0006706)2.29919456
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29591053
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.29591053
41Anencephaly (HP:0002323)2.27001656
42Lipid accumulation in hepatocytes (HP:0006561)2.26337268
43Medial flaring of the eyebrow (HP:0010747)2.21967193
44Delayed CNS myelination (HP:0002188)2.19976203
45Abnormality of the renal medulla (HP:0100957)2.14317805
46Entropion (HP:0000621)2.11297311
47Decreased central vision (HP:0007663)2.08868969
48Methylmalonic acidemia (HP:0002912)2.07786335
49Abolished electroretinogram (ERG) (HP:0000550)2.07430646
50Type 2 muscle fiber atrophy (HP:0003554)2.04642981
51Morphological abnormality of the pyramidal tract (HP:0002062)2.04574083
52Gaze-evoked nystagmus (HP:0000640)2.04362088
53Increased serum lactate (HP:0002151)2.02818478
54Abnormality of the costochondral junction (HP:0000919)2.01326666
55Abnormality of cells of the erythroid lineage (HP:0012130)2.00734557
56Renal Fanconi syndrome (HP:0001994)1.96894537
57Urethral obstruction (HP:0000796)1.96326025
58Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94173282
59Porencephaly (HP:0002132)1.93457864
60Pachygyria (HP:0001302)1.91786204
61Prolonged neonatal jaundice (HP:0006579)1.91082893
62Abnormal ciliary motility (HP:0012262)1.90048881
63Poikiloderma (HP:0001029)1.89469416
64Short tibia (HP:0005736)1.88947904
65Attenuation of retinal blood vessels (HP:0007843)1.84864120
66Abnormal protein glycosylation (HP:0012346)1.84787785
67Abnormal glycosylation (HP:0012345)1.84787785
68Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.84787785
69Abnormal protein N-linked glycosylation (HP:0012347)1.84787785
70Aplasia/Hypoplasia of the tibia (HP:0005772)1.83707287
71Myokymia (HP:0002411)1.83092748
72Leukodystrophy (HP:0002415)1.82851885
73IgG deficiency (HP:0004315)1.80665980
74Abnormal biliary tract physiology (HP:0012439)1.80338013
75Bile duct proliferation (HP:0001408)1.80338013
76Enlarged epiphyses (HP:0010580)1.79990659
77Increased IgM level (HP:0003496)1.79966229
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79912558
79Pendular nystagmus (HP:0012043)1.79472904
80Chronic obstructive pulmonary disease (HP:0006510)1.77939685
81Obstructive lung disease (HP:0006536)1.77939685
82Muscle hypertrophy of the lower extremities (HP:0008968)1.77815054
83Drooling (HP:0002307)1.77785737
84Exercise intolerance (HP:0003546)1.77099282
85Abnormal hemoglobin (HP:0011902)1.76330445
86Hepatic necrosis (HP:0002605)1.76110465
87Dynein arm defect of respiratory motile cilia (HP:0012255)1.75954275
88Absent/shortened dynein arms (HP:0200106)1.75954275
89Abnormal drinking behavior (HP:0030082)1.75188359
90Polydipsia (HP:0001959)1.75188359
91Radial bowing (HP:0002986)1.74645000
92Increased intramyocellular lipid droplets (HP:0012240)1.74447919
93Opisthotonus (HP:0002179)1.74407232
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.73835614
95Tubulointerstitial nephritis (HP:0001970)1.71326112
96Abnormal respiratory epithelium morphology (HP:0012253)1.70701657
97Abnormal respiratory motile cilium morphology (HP:0005938)1.70701657
98Congenital stationary night blindness (HP:0007642)1.66926399
99Lethargy (HP:0001254)1.66921582
100Fatigue (HP:0012378)1.66717086

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.68599170
2PINK13.13972850
3TXK3.10367684
4AKT32.68501234
5TNK22.60368607
6INSRR2.33974903
7FRK2.11208432
8WNK41.97894454
9EIF2AK31.94506040
10TEC1.93964560
11MAP3K41.93381629
12BMPR1B1.92616251
13ADRBK21.84143431
14ZAK1.82721416
15NUAK11.76816015
16TRIM281.74874688
17NTRK21.74401572
18BTK1.67094398
19TAOK31.58158846
20MAP2K71.54707642
21MAP4K21.46763118
22KIT1.38944125
23TYRO31.37089453
24CAMKK21.35648044
25DYRK21.35579832
26ITK1.28632145
27SRPK11.23119546
28PIM21.16371561
29PHKG21.15883739
30PHKG11.15883739
31GRK11.12278481
32EIF2AK21.09693531
33TGFBR11.07120028
34RIPK11.06778611
35MYLK1.00613686
36RPS6KA51.00054430
37CSF1R0.99963672
38PDK20.99742208
39ACVR1B0.99341325
40PNCK0.96657089
41STK390.94805222
42PRKCE0.90897954
43LYN0.90036240
44MARK10.88962633
45BCKDK0.87302463
46CSNK1G30.87085646
47WNK30.85618620
48CSNK1G20.84931794
49PAK30.82823222
50PRKCQ0.82243199
51MKNK10.82190689
52BRD40.78105082
53ERBB30.77274757
54GRK70.76326705
55DMPK0.76116452
56CSNK1A1L0.74997885
57NTRK30.71035648
58OBSCN0.69537400
59SYK0.69303085
60CSNK1G10.69002986
61PRKCG0.68192258
62PLK40.67791067
63CDK190.67359418
64TIE10.65455195
65IKBKB0.64081113
66PRKACA0.64043724
67BMPR20.61729994
68ILK0.61383821
69DAPK20.61245605
70LCK0.60865810
71ABL10.60766011
72MAPK120.60375649
73MKNK20.58914066
74CHEK20.58811469
75PIK3CG0.58781129
76NEK10.58516262
77DYRK1B0.58155566
78FLT30.57847282
79ADRBK10.57632467
80MAP2K40.57389247
81PIK3CA0.55944814
82CAMK2D0.54888940
83CSNK1A10.53450933
84TYK20.52739983
85IGF1R0.52169125
86MAP4K10.51677476
87CAMK10.51300848
88LRRK20.51180510
89PKN10.50262453
90OXSR10.49955396
91IKBKE0.49194545
92PRKG10.48453909
93RPS6KA40.47925596
94JAK30.47679576
95PIM10.47154467
96CAMK2A0.47063358
97CSK0.45464338
98CDK140.44663434
99ATR0.42299361
100CAMKK10.38100450

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.13806015
2Ribosome_Homo sapiens_hsa030103.70400035
3Oxidative phosphorylation_Homo sapiens_hsa001903.44701000
4Autoimmune thyroid disease_Homo sapiens_hsa053203.24535313
5Allograft rejection_Homo sapiens_hsa053303.19946545
6Graft-versus-host disease_Homo sapiens_hsa053323.17506827
7Parkinsons disease_Homo sapiens_hsa050123.03599952
8Protein export_Homo sapiens_hsa030602.93322413
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.79323820
10Type I diabetes mellitus_Homo sapiens_hsa049402.72208426
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.34280899
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26441855
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95863098
14Huntingtons disease_Homo sapiens_hsa050161.90089380
15Alzheimers disease_Homo sapiens_hsa050101.79325808
16Rheumatoid arthritis_Homo sapiens_hsa053231.71972149
17Cardiac muscle contraction_Homo sapiens_hsa042601.66886105
18Proteasome_Homo sapiens_hsa030501.66331898
19Viral myocarditis_Homo sapiens_hsa054161.62194235
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59438117
21Antigen processing and presentation_Homo sapiens_hsa046121.56762801
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54582874
23Sulfur metabolism_Homo sapiens_hsa009201.53777493
24RNA polymerase_Homo sapiens_hsa030201.53066002
25Propanoate metabolism_Homo sapiens_hsa006401.51934406
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44547961
27Basal transcription factors_Homo sapiens_hsa030221.44402326
28Linoleic acid metabolism_Homo sapiens_hsa005911.43573501
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34367780
30Staphylococcus aureus infection_Homo sapiens_hsa051501.33791747
31Tryptophan metabolism_Homo sapiens_hsa003801.31465523
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24731806
33RNA degradation_Homo sapiens_hsa030181.23034411
34Butanoate metabolism_Homo sapiens_hsa006501.08972820
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.07248752
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05659345
37Nitrogen metabolism_Homo sapiens_hsa009101.03196260
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94181953
39Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91285764
40Phototransduction_Homo sapiens_hsa047440.91202994
41Caffeine metabolism_Homo sapiens_hsa002320.89122262
42Leishmaniasis_Homo sapiens_hsa051400.87658258
43Systemic lupus erythematosus_Homo sapiens_hsa053220.86761370
44Morphine addiction_Homo sapiens_hsa050320.85683663
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85048585
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73669031
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73056694
48Homologous recombination_Homo sapiens_hsa034400.72811502
49Ether lipid metabolism_Homo sapiens_hsa005650.72504730
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70843685
51Steroid biosynthesis_Homo sapiens_hsa001000.70659490
52Primary immunodeficiency_Homo sapiens_hsa053400.69176269
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63971384
54Nicotine addiction_Homo sapiens_hsa050330.63029489
55Base excision repair_Homo sapiens_hsa034100.62194668
56SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58233193
57Peroxisome_Homo sapiens_hsa041460.56882099
58Epstein-Barr virus infection_Homo sapiens_hsa051690.56565597
59Fanconi anemia pathway_Homo sapiens_hsa034600.56437749
60beta-Alanine metabolism_Homo sapiens_hsa004100.56217009
61Olfactory transduction_Homo sapiens_hsa047400.53260107
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.52904332
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.51149735
64Arachidonic acid metabolism_Homo sapiens_hsa005900.47649669
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47260230
66Taste transduction_Homo sapiens_hsa047420.47132275
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46896575
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46500893
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45789848
70Chemical carcinogenesis_Homo sapiens_hsa052040.45244967
71Fatty acid elongation_Homo sapiens_hsa000620.45151703
72Serotonergic synapse_Homo sapiens_hsa047260.44726901
73Purine metabolism_Homo sapiens_hsa002300.44328207
74Salivary secretion_Homo sapiens_hsa049700.43639106
75Toxoplasmosis_Homo sapiens_hsa051450.43021562
76Ovarian steroidogenesis_Homo sapiens_hsa049130.41358614
77Metabolic pathways_Homo sapiens_hsa011000.40452494
78GABAergic synapse_Homo sapiens_hsa047270.39665215
79Circadian rhythm_Homo sapiens_hsa047100.39381043
80Regulation of autophagy_Homo sapiens_hsa041400.39325051
81Tuberculosis_Homo sapiens_hsa051520.37542008
82Circadian entrainment_Homo sapiens_hsa047130.37190113
83Retinol metabolism_Homo sapiens_hsa008300.37100147
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36417497
85NF-kappa B signaling pathway_Homo sapiens_hsa040640.34220737
86Glutamatergic synapse_Homo sapiens_hsa047240.33854230
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33630459
88Herpes simplex infection_Homo sapiens_hsa051680.33601724
89Spliceosome_Homo sapiens_hsa030400.33495865
90Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32846479
91Collecting duct acid secretion_Homo sapiens_hsa049660.31555278
92Influenza A_Homo sapiens_hsa051640.31221259
93RNA transport_Homo sapiens_hsa030130.31000941
94Fat digestion and absorption_Homo sapiens_hsa049750.30218650
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27617111
96Phagosome_Homo sapiens_hsa041450.27161340
97Cholinergic synapse_Homo sapiens_hsa047250.26096737
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25857259
99Synaptic vesicle cycle_Homo sapiens_hsa047210.25365307
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24438367

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