ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of DNA methylation (GO:0044030)	8.32304902
2	piRNA metabolic process (GO:0034587)	8.17771773
3	regulation of meiosis I (GO:0060631)	7.52303764
4	retinal cone cell development (GO:0046549)	6.99976886
5	regulation of female gonad development (GO:2000194)	6.59499915
6	meiotic cell cycle (GO:0051321)	6.30203841
7	DNA methylation involved in gamete generation (GO:0043046)	6.12523408
8	behavioral response to nicotine (GO:0035095)	5.40440278
9	positive regulation of gastrulation (GO:2000543)	5.31703746
10	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	5.18880582
11	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	5.18880582
12	positive regulation of mitotic sister chromatid separation (GO:1901970)	5.18880582
13	centriole replication (GO:0007099)	5.08215426
14	gene silencing by RNA (GO:0031047)	4.94088277
15	multicellular organism reproduction (GO:0032504)	4.90843995
16	female gamete generation (GO:0007292)	4.78605236
17	regulation of acrosome reaction (GO:0060046)	4.73771861
18	regulation of cell maturation (GO:1903429)	4.66133316
19	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	4.63117495
20	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	4.55356370
21	regulation of steroid hormone secretion (GO:2000831)	4.48030174
22	positive regulation of histone H3-K4 methylation (GO:0051571)	4.39326219
23	synapsis (GO:0007129)	4.37819129
24	male meiosis (GO:0007140)	4.37440807
25	male meiosis I (GO:0007141)	4.36856774
26	substrate-independent telencephalic tangential migration (GO:0021826)	4.30432570
27	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.30432570
28	rRNA catabolic process (GO:0016075)	4.11904510
29	pyrimidine dimer repair (GO:0006290)	4.07519001
30	neuron fate determination (GO:0048664)	4.07402982
31	protein localization to chromosome, centromeric region (GO:0071459)	3.95434722
32	primitive streak formation (GO:0090009)	3.95019674
33	regulation of meiosis (GO:0040020)	3.93908859
34	regulation of histone H3-K9 methylation (GO:0051570)	3.87847590
35	protein localization to kinetochore (GO:0034501)	3.83295993
36	positive regulation of chromosome segregation (GO:0051984)	3.81876775
37	glycine transport (GO:0015816)	3.81371607
38	somite rostral/caudal axis specification (GO:0032525)	3.77803404
39	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.75829202
40	relaxation of smooth muscle (GO:0044557)	3.63800978
41	meiotic nuclear division (GO:0007126)	3.55500825
42	microtubule severing (GO:0051013)	3.55496132
43	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.55032908
44	synaptonemal complex organization (GO:0070193)	3.53963369
45	negative regulation of cAMP-mediated signaling (GO:0043951)	3.51779388
46	protein localization to chromosome (GO:0034502)	3.51234579
47	synaptonemal complex assembly (GO:0007130)	3.51100900
48	chromosome organization involved in meiosis (GO:0070192)	3.50594048
49	oocyte development (GO:0048599)	3.42417437
50	organelle membrane fusion (GO:0090174)	3.42056264
51	regulation of meiotic cell cycle (GO:0051445)	3.42030886
52	protein K11-linked deubiquitination (GO:0035871)	3.40311633
53	meiosis I (GO:0007127)	3.39097638
54	mitotic metaphase plate congression (GO:0007080)	3.38861783
55	protein import into peroxisome matrix (GO:0016558)	3.36421566
56	labyrinthine layer development (GO:0060711)	3.33508935
57	N-terminal protein amino acid acetylation (GO:0006474)	3.33298212
58	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)	3.32480835
59	RNA destabilization (GO:0050779)	3.32243937
60	positive regulation of meiotic cell cycle (GO:0051446)	3.31361037
61	regulation of mitotic spindle checkpoint (GO:1903504)	3.30243518
62	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.30243518
63	positive regulation of meiosis (GO:0045836)	3.26740720
64	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.26548976
65	termination of RNA polymerase I transcription (GO:0006363)	3.26167970
66	type B pancreatic cell proliferation (GO:0044342)	3.22211022
67	negative regulation of execution phase of apoptosis (GO:1900118)	3.21229274
68	regulation of spindle checkpoint (GO:0090231)	3.20413510
69	oogenesis (GO:0048477)	3.17521543
70	centriole assembly (GO:0098534)	3.13613153
71	transcription initiation from RNA polymerase I promoter (GO:0006361)	3.08079546
72	gene silencing (GO:0016458)	3.05079932
73	meiotic cell cycle process (GO:1903046)	3.03092362
74	CENP-A containing nucleosome assembly (GO:0034080)	3.02477135
75	negative regulation of reproductive process (GO:2000242)	3.01844009
76	establishment of chromosome localization (GO:0051303)	3.00041691
77	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.99886828
78	DNA replication-dependent nucleosome organization (GO:0034723)	2.96643888
79	DNA replication-dependent nucleosome assembly (GO:0006335)	2.96643888
80	regulation of chromatin silencing (GO:0031935)	2.94793241
81	fertilization (GO:0009566)	2.94593542
82	biotin metabolic process (GO:0006768)	2.91836336
83	phenylpropanoid metabolic process (GO:0009698)	2.91481526
84	negative regulation of histone methylation (GO:0031061)	2.89904149
85	dopamine biosynthetic process (GO:0042416)	2.87866267
86	postreplication repair (GO:0006301)	2.87042697
87	translesion synthesis (GO:0019985)	2.86946913
88	reproduction (GO:0000003)	2.86170190
89	chromatin remodeling at centromere (GO:0031055)	2.85112442
90	genitalia morphogenesis (GO:0035112)	2.83411265
91	DNA damage induced protein phosphorylation (GO:0006975)	2.76717570
92	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.75710023
93	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.74098103
94	transcription from RNA polymerase I promoter (GO:0006360)	2.72848704
95	magnesium ion transport (GO:0015693)	2.72542488
96	long-chain fatty acid biosynthetic process (GO:0042759)	2.71581257
97	attachment of spindle microtubules to kinetochore (GO:0008608)	2.71523160
98	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.70213843
99	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.69431393
100	interleukin-6-mediated signaling pathway (GO:0070102)	2.68976252

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.04592704
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.68728322
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.76680057
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.69022431
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.41753302
6	VDR_22108803_ChIP-Seq_LS180_Human	3.19681235
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.08501041
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.99599177
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.62382805
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.57145306
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.15172613
12	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.10993977
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.03314235
14	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.96371542
15	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.96371542
16	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.96371542
17	EWS_26573619_Chip-Seq_HEK293_Human	1.94260371
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79202564
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.77356158
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.71380967
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.71380967
22	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.67789530
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.64961108
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.64851918
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63081984
26	P300_19829295_ChIP-Seq_ESCs_Human	1.60717010
27	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.58195416
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.57803158
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.55756732
30	TCF4_23295773_ChIP-Seq_U87_Human	1.54762350
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.54484116
32	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.53320216
33	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.51805161
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.49634842
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48461563
36	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.48122795
37	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.47640642
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.47472370
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47472370
40	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.45481455
41	STAT3_23295773_ChIP-Seq_U87_Human	1.45287637
42	FUS_26573619_Chip-Seq_HEK293_Human	1.44789553
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.42804274
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.40010897
45	SMAD4_21799915_ChIP-Seq_A2780_Human	1.35695933
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.33379894
47	TP53_16413492_ChIP-PET_HCT116_Human	1.32541959
48	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.32045247
49	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.31071781
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.30121753
51	AR_25329375_ChIP-Seq_VCAP_Human	1.28498189
52	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.24762821
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.22668493
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20459257
55	HTT_18923047_ChIP-ChIP_STHdh_Human	1.19993663
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.19849262
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16654836
58	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16654836
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15523958
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.14633392
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.14083546
62	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13908464
63	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.13150240
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.12890627
65	SMRT_27268052_Chip-Seq_Bcells_Human	1.09407307
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08900190
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08534796
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07944670
69	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.07856758
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.07162547
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05874664
72	AR_20517297_ChIP-Seq_VCAP_Human	1.05261544
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.05111354
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04223616
75	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03956825
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03546190
77	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02078816
78	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01995907
79	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99989879
80	NANOG_20526341_ChIP-Seq_ESCs_Human	0.98729956
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97825664
82	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97587936
83	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97475409
84	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.97228162
85	CBP_21632823_ChIP-Seq_H3396_Human	0.97032878
86	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.96593938
87	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.96236455
88	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.95598624
89	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.94843208
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.94641590
91	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.94143610
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.93595482
93	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.93595482
94	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93518175
95	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.92875075
96	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.92644402
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92638283
98	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91908112
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.90584174
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.90466070

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	6.97120412
2	MP0008877_abnormal_DNA_methylation	6.22255009
3	MP0002138_abnormal_hepatobiliary_system	5.83484825
4	MP0006292_abnormal_olfactory_placode	3.96443300
5	MP0008789_abnormal_olfactory_epithelium	3.38051923
6	MP0000569_abnormal_digit_pigmentation	3.23851924
7	MP0005395_other_phenotype	2.61667120
8	MP0000372_irregular_coat_pigmentation	2.57846937
9	MP0010234_abnormal_vibrissa_follicle	2.54940885
10	MP0002234_abnormal_pharynx_morphology	2.53825573
11	MP0003890_abnormal_embryonic-extraembry	2.51707091
12	MP0005394_taste/olfaction_phenotype	2.45986354
13	MP0005499_abnormal_olfactory_system	2.45986354
14	MP0002139_abnormal_hepatobiliary_system	2.32904911
15	MP0003252_abnormal_bile_duct	2.24262296
16	MP0000015_abnormal_ear_pigmentation	2.11916994
17	MP0002160_abnormal_reproductive_system	2.00383778
18	MP0005646_abnormal_pituitary_gland	1.97397448
19	MP0005410_abnormal_fertilization	1.94941881
20	MP0005085_abnormal_gallbladder_physiolo	1.81618162
21	MP0003950_abnormal_plasma_membrane	1.79932088
22	MP0005075_abnormal_melanosome_morpholog	1.76010756
23	MP0001929_abnormal_gametogenesis	1.74513251
24	MP0002210_abnormal_sex_determination	1.74013649
25	MP0008058_abnormal_DNA_repair	1.72712014
26	MP0003699_abnormal_female_reproductive	1.70531604
27	MP0005360_urolithiasis	1.70385212
28	MP0003183_abnormal_peptide_metabolism	1.69791442
29	MP0003693_abnormal_embryo_hatching	1.64207003
30	MP0001293_anophthalmia	1.61452072
31	MP0005645_abnormal_hypothalamus_physiol	1.54820396
32	MP0010030_abnormal_orbit_morphology	1.50028967
33	MP0005174_abnormal_tail_pigmentation	1.47977352
34	MP0004142_abnormal_muscle_tone	1.45658455
35	MP0000653_abnormal_sex_gland	1.43026106
36	MP0000631_abnormal_neuroendocrine_gland	1.42099359
37	MP0005503_abnormal_tendon_morphology	1.37962565
38	MP0003787_abnormal_imprinting	1.31979228
39	MP0004043_abnormal_pH_regulation	1.28927002
40	MP0005389_reproductive_system_phenotype	1.28565231
41	MP0000427_abnormal_hair_cycle	1.27389199
42	MP0002161_abnormal_fertility/fecundity	1.21603893
43	MP0005551_abnormal_eye_electrophysiolog	1.20960725
44	MP0010307_abnormal_tumor_latency	1.19526797
45	MP0003698_abnormal_male_reproductive	1.17087250
46	MP0006072_abnormal_retinal_apoptosis	1.16597326
47	MP0003121_genomic_imprinting	1.15035556
48	MP0001145_abnormal_male_reproductive	1.14314982
49	MP0001984_abnormal_olfaction	1.11959159
50	MP0006276_abnormal_autonomic_nervous	1.11196911
51	MP0003136_yellow_coat_color	1.08869310
52	MP0002272_abnormal_nervous_system	1.06915458
53	MP0010094_abnormal_chromosome_stability	1.05248550
54	MP0000566_synostosis	1.04483502
55	MP0004084_abnormal_cardiac_muscle	1.00729633
56	MP0003879_abnormal_hair_cell	0.98891654
57	MP0009697_abnormal_copulation	0.95387640
58	MP0010678_abnormal_skin_adnexa	0.92271812
59	MP0008875_abnormal_xenobiotic_pharmacok	0.89470979
60	MP0001664_abnormal_digestion	0.88360687
61	MP0002095_abnormal_skin_pigmentation	0.87970470
62	MP0003077_abnormal_cell_cycle	0.87727964
63	MP0005647_abnormal_sex_gland	0.87309234
64	MP0006138_congestive_heart_failure	0.80727074
65	MP0002928_abnormal_bile_duct	0.79818770
66	MP0002938_white_spotting	0.78585144
67	MP0008057_abnormal_DNA_replication	0.78248290
68	MP0003195_calcinosis	0.76910149
69	MP0002233_abnormal_nose_morphology	0.75281085
70	MP0000762_abnormal_tongue_morphology	0.75146041
71	MP0001119_abnormal_female_reproductive	0.73626872
72	MP0008775_abnormal_heart_ventricle	0.69221029
73	MP0008004_abnormal_stomach_pH	0.68911627
74	MP0002006_tumorigenesis	0.66887690
75	MP0000049_abnormal_middle_ear	0.61012806
76	MP0005253_abnormal_eye_physiology	0.60182067
77	MP0001188_hyperpigmentation	0.58636064
78	MP0002102_abnormal_ear_morphology	0.57854008
79	MP0001919_abnormal_reproductive_system	0.57066400
80	MP0001756_abnormal_urination	0.56928951
81	MP0003119_abnormal_digestive_system	0.56675249
82	MP0009379_abnormal_foot_pigmentation	0.56641747
83	MP0009745_abnormal_behavioral_response	0.56524762
84	MP0000026_abnormal_inner_ear	0.55191220
85	MP0003111_abnormal_nucleus_morphology	0.54274157
86	MP0002638_abnormal_pupillary_reflex	0.54274006
87	MP0008995_early_reproductive_senescence	0.53360204
88	MP0003122_maternal_imprinting	0.52807650
89	MP0000613_abnormal_salivary_gland	0.52624968
90	MP0002751_abnormal_autonomic_nervous	0.52568064
91	MP0001529_abnormal_vocalization	0.52283522
92	MP0003045_fibrosis	0.51167720
93	MP0001968_abnormal_touch/_nociception	0.50392830
94	MP0004924_abnormal_behavior	0.49993185
95	MP0005386_behavior/neurological_phenoty	0.49993185
96	MP0003646_muscle_fatigue	0.48884395
97	MP0005508_abnormal_skeleton_morphology	0.48439813
98	MP0000647_abnormal_sebaceous_gland	0.44656407
99	MP0002090_abnormal_vision	0.43939270
100	MP0001486_abnormal_startle_reflex	0.43469816

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Fair hair (HP:0002286)	6.23850546
2	Supernumerary spleens (HP:0009799)	6.05336499
3	Generalized hypopigmentation of hair (HP:0011358)	4.64404986
4	Abnormality of the labia minora (HP:0012880)	4.03611346
5	Anterior segment dysgenesis (HP:0007700)	4.00726596
6	Oligodactyly (hands) (HP:0001180)	3.95593557
7	Facial hemangioma (HP:0000329)	3.94059324
8	Median cleft lip (HP:0000161)	3.64359733
9	Azoospermia (HP:0000027)	3.43180825
10	Anhidrosis (HP:0000970)	3.42515804
11	Type II lissencephaly (HP:0007260)	3.39494838
12	Hypophosphatemic rickets (HP:0004912)	3.37843507
13	Osteomalacia (HP:0002749)	3.20058906
14	Septo-optic dysplasia (HP:0100842)	3.12043960
15	Optic nerve hypoplasia (HP:0000609)	3.05124723
16	Type I transferrin isoform profile (HP:0003642)	3.04207351
17	Severe visual impairment (HP:0001141)	3.01027782
18	Cholecystitis (HP:0001082)	2.99917609
19	Abnormal gallbladder physiology (HP:0012438)	2.99917609
20	Oligodactyly (HP:0012165)	2.99402682
21	Capillary hemangiomas (HP:0005306)	2.97759558
22	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.92263144
23	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.83739701
24	Hypoplasia of the fovea (HP:0007750)	2.83739701
25	Congenital, generalized hypertrichosis (HP:0004540)	2.78055841
26	Molar tooth sign on MRI (HP:0002419)	2.77750009
27	Abnormality of midbrain morphology (HP:0002418)	2.77750009
28	Short tibia (HP:0005736)	2.76365616
29	Lip pit (HP:0100267)	2.72193603
30	Chromsome breakage (HP:0040012)	2.71630012
31	Bile duct proliferation (HP:0001408)	2.66588660
32	Abnormal biliary tract physiology (HP:0012439)	2.66588660
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.65585670
34	Impulsivity (HP:0100710)	2.59928407
35	Wrist flexion contracture (HP:0001239)	2.56902493
36	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.55251856
37	Chronic hepatic failure (HP:0100626)	2.49973020
38	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.49642384
39	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.48400569
40	Sensorimotor neuropathy (HP:0007141)	2.48194703
41	Abdominal situs inversus (HP:0003363)	2.46430718
42	Abnormality of abdominal situs (HP:0011620)	2.46430718
43	Absent septum pellucidum (HP:0001331)	2.45982978
44	Intrahepatic cholestasis (HP:0001406)	2.45501058
45	Dry hair (HP:0011359)	2.45314233
46	Pachygyria (HP:0001302)	2.39531746
47	Type 2 muscle fiber atrophy (HP:0003554)	2.38801839
48	Abnormality of the fovea (HP:0000493)	2.34214177
49	Abnormality of the septum pellucidum (HP:0007375)	2.34045930
50	Abnormality of secondary sexual hair (HP:0009888)	2.32934245
51	Abnormality of the axillary hair (HP:0100134)	2.32934245
52	Conjugated hyperbilirubinemia (HP:0002908)	2.32691490
53	Abnormal spermatogenesis (HP:0008669)	2.25694485
54	Enlarged penis (HP:0000040)	2.25196294
55	Gaze-evoked nystagmus (HP:0000640)	2.23935474
56	Pancreatic cysts (HP:0001737)	2.23223628
57	Truncal obesity (HP:0001956)	2.22125935
58	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.17286849
59	Abnormal glycosylation (HP:0012345)	2.14592758
60	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.14592758
61	Abnormal protein N-linked glycosylation (HP:0012347)	2.14592758
62	Abnormal protein glycosylation (HP:0012346)	2.14592758
63	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08834667
64	Congenital stationary night blindness (HP:0007642)	2.07817983
65	Hypohidrosis (HP:0000966)	2.04536458
66	Muscle fiber atrophy (HP:0100295)	2.03746500
67	Metaphyseal irregularity (HP:0003025)	2.02887962
68	Prostate neoplasm (HP:0100787)	2.01941831
69	Abnormality of the renal cortex (HP:0011035)	2.01086542
70	Non-midline cleft lip (HP:0100335)	1.99227941
71	Retinal dysplasia (HP:0007973)	1.94266730
72	Brushfield spots (HP:0001088)	1.91468026
73	Pancreatic fibrosis (HP:0100732)	1.90506046
74	Cone-rod dystrophy (HP:0000548)	1.90359370
75	Abnormality of the ileum (HP:0001549)	1.88481995
76	Pendular nystagmus (HP:0012043)	1.88020290
77	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.86530424
78	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.86530424
79	Infertility (HP:0000789)	1.86078356
80	Albinism (HP:0001022)	1.85753216
81	Congenital sensorineural hearing impairment (HP:0008527)	1.83541066
82	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83117035
83	Bicornuate uterus (HP:0000813)	1.83059672
84	Stillbirth (HP:0003826)	1.82793454
85	Papillary thyroid carcinoma (HP:0002895)	1.80634461
86	Conjunctival telangiectasia (HP:0000524)	1.77531550
87	Hypotrichosis (HP:0001006)	1.76961402
88	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.76817211
89	Autoamputation (HP:0001218)	1.75889378
90	Tibial bowing (HP:0002982)	1.75026855
91	Short thumb (HP:0009778)	1.72857471
92	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.71551159
93	Attenuation of retinal blood vessels (HP:0007843)	1.70518760
94	Absent radius (HP:0003974)	1.69890091
95	Decreased circulating renin level (HP:0003351)	1.69696294
96	Hypothermia (HP:0002045)	1.69580408
97	Skin pits (HP:0100276)	1.69033723
98	Abnormality of the carotid arteries (HP:0005344)	1.67820217
99	Proximal tubulopathy (HP:0000114)	1.67413846
100	Volvulus (HP:0002580)	1.64962316

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ARAF	5.26550331
2	BRAF	3.53173201
3	MAP3K9	3.38371742
4	MAP3K13	3.33700757
5	MET	3.16969957
6	CDK9	2.99694547
7	EIF2AK3	2.84362994
8	TAOK3	2.71550884
9	MAP4K2	2.62684278
10	EIF2AK1	2.50935023
11	RAF1	2.40465111
12	NUAK1	2.29946464
13	ZAK	2.18761287
14	NEK6	1.97806183
15	TTK	1.90598207
16	STK39	1.86097930
17	FRK	1.83420319
18	PRKCI	1.78232919
19	ADRBK2	1.64607600
20	MKNK2	1.62721783
21	KSR2	1.49913826
22	MST4	1.48706279
23	TNIK	1.45778548
24	CDC7	1.44970237
25	WNK4	1.43649722
26	NTRK3	1.41990467
27	PIM2	1.36636341
28	AKT3	1.32518876
29	MOS	1.29840162
30	AURKA	1.28736811
31	PNCK	1.27275277
32	KIT	1.26026289
33	TNK2	1.24641368
34	MKNK1	1.24527558
35	GRK1	1.21061387
36	CAMKK2	1.14473163
37	KSR1	1.10823897
38	INSRR	1.02991563
39	TYRO3	1.01329125
40	TIE1	1.00907911
41	PRKD3	0.88056290
42	TEC	0.87370202
43	NEK9	0.86296637
44	STK24	0.83299240
45	OXSR1	0.81109176
46	EPHA3	0.80748740
47	PLK1	0.78727571
48	CDK7	0.78085577
49	MAPKAPK5	0.74089745
50	CAMK1G	0.71882848
51	LMTK2	0.69314632
52	VRK1	0.69113992
53	BMPR1B	0.68751975
54	STK3	0.68392079
55	BRSK2	0.65026392
56	TSSK6	0.64664146
57	CHEK2	0.64632182
58	PRKAA1	0.64258589
59	CAMK1D	0.63298553
60	PIK3CA	0.61165179
61	PLK3	0.61017282
62	RPS6KA4	0.59351549
63	PIM1	0.58286820
64	TRIM28	0.54124664
65	PKN1	0.53743549
66	PRKCE	0.52576138
67	MAPKAPK3	0.52139595
68	WNK1	0.49768287
69	BMPR2	0.49718264
70	RPS6KA5	0.48980471
71	NTRK2	0.48690310
72	PRKG1	0.46904497
73	TGFBR1	0.46901769
74	CSNK1D	0.43831632
75	AURKB	0.42761949
76	NLK	0.42030956
77	LATS1	0.41577453
78	GRK5	0.41123986
79	CAMK2A	0.41101348
80	ATR	0.40835140
81	MAP3K8	0.38335640
82	PRKCG	0.38197352
83	ADRBK1	0.37626934
84	CLK1	0.37127150
85	MARK3	0.35184049
86	CHUK	0.34655776
87	CAMK1	0.32792932
88	PRKACA	0.32671607
89	PRKD2	0.31782852
90	TXK	0.29798168
91	PLK2	0.29137040
92	PRKACB	0.28926751
93	MATK	0.28387741
94	CDK8	0.26181733
95	MELK	0.25763416
96	IKBKB	0.25319965
97	PLK4	0.24953985
98	CHEK1	0.24657216
99	MAP3K14	0.24539898
100	TLK1	0.24067851

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.51158258
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.93092956
3	Caffeine metabolism_Homo sapiens_hsa00232	3.49675110
4	RNA degradation_Homo sapiens_hsa03018	3.46097822
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.29028634
6	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	2.78583538
7	Cell cycle_Homo sapiens_hsa04110	2.67947854
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.54390902
9	RNA polymerase_Homo sapiens_hsa03020	2.29814141
10	Homologous recombination_Homo sapiens_hsa03440	2.12222504
11	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.10303516
12	Mismatch repair_Homo sapiens_hsa03430	2.01459190
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95703118
14	Circadian rhythm_Homo sapiens_hsa04710	1.95073316
15	Phototransduction_Homo sapiens_hsa04744	1.91660119
16	Olfactory transduction_Homo sapiens_hsa04740	1.90483257
17	Nicotine addiction_Homo sapiens_hsa05033	1.87887966
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.85883430
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.80335754
20	Oocyte meiosis_Homo sapiens_hsa04114	1.65617644
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.63769794
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.63720059
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.62309936
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.49664302
25	ABC transporters_Homo sapiens_hsa02010	1.44876047
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.43057525
27	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.38317896
28	Long-term depression_Homo sapiens_hsa04730	1.27775563
29	Regulation of autophagy_Homo sapiens_hsa04140	1.26813036
30	p53 signaling pathway_Homo sapiens_hsa04115	1.23839402
31	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.22418299
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.21667359
33	Histidine metabolism_Homo sapiens_hsa00340	1.21636879
34	Base excision repair_Homo sapiens_hsa03410	1.18534997
35	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.17963693
36	Serotonergic synapse_Homo sapiens_hsa04726	1.16273933
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.09949570
38	Peroxisome_Homo sapiens_hsa04146	1.09753037
39	Morphine addiction_Homo sapiens_hsa05032	1.09380934
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.08974392
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99179728
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.97146977
43	Thyroid cancer_Homo sapiens_hsa05216	0.96588541
44	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96280291
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.95877628
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.95460106
47	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92086610
48	RNA transport_Homo sapiens_hsa03013	0.88166153
49	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.83405508
50	Folate biosynthesis_Homo sapiens_hsa00790	0.81228713
51	Propanoate metabolism_Homo sapiens_hsa00640	0.72681507
52	Bile secretion_Homo sapiens_hsa04976	0.67616602
53	Purine metabolism_Homo sapiens_hsa00230	0.66281228
54	mTOR signaling pathway_Homo sapiens_hsa04150	0.65293283
55	Butanoate metabolism_Homo sapiens_hsa00650	0.58523424
56	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58412338
57	Type II diabetes mellitus_Homo sapiens_hsa04930	0.53781289
58	Retinol metabolism_Homo sapiens_hsa00830	0.52672555
59	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.52184746
60	Gap junction_Homo sapiens_hsa04540	0.51474532
61	Ras signaling pathway_Homo sapiens_hsa04014	0.50237595
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49573964
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.48799795
64	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47924618
65	GABAergic synapse_Homo sapiens_hsa04727	0.45865826
66	Proteasome_Homo sapiens_hsa03050	0.45455997
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45196015
68	Circadian entrainment_Homo sapiens_hsa04713	0.43122134
69	Huntingtons disease_Homo sapiens_hsa05016	0.42234589
70	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.41535843
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.40335850
72	Sulfur metabolism_Homo sapiens_hsa00920	0.38871025
73	Melanoma_Homo sapiens_hsa05218	0.37040895
74	Fatty acid degradation_Homo sapiens_hsa00071	0.35612229
75	DNA replication_Homo sapiens_hsa03030	0.34754281
76	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.34536424
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.33195198
78	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.30777360
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.30106684
80	Asthma_Homo sapiens_hsa05310	0.28072145
81	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25809725
82	Taste transduction_Homo sapiens_hsa04742	0.25745204
83	Salivary secretion_Homo sapiens_hsa04970	0.25022783
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.24676846
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.23616901
86	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.23375009
87	FoxO signaling pathway_Homo sapiens_hsa04068	0.23098244
88	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.21668327
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.21513074
90	Oxidative phosphorylation_Homo sapiens_hsa00190	0.19203519
91	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.18799036
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.17000698
93	Apoptosis_Homo sapiens_hsa04210	0.16604443
94	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.16462985
95	cAMP signaling pathway_Homo sapiens_hsa04024	0.14981711
96	Protein export_Homo sapiens_hsa03060	0.14364922
97	Herpes simplex infection_Homo sapiens_hsa05168	0.13167927
98	Insulin secretion_Homo sapiens_hsa04911	0.11042265
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.11025716
100	Hippo signaling pathway_Homo sapiens_hsa04390	0.09695859

ST13P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »