ST13P13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1anatomical structure regression (GO:0060033)8.92420816
2natural killer cell activation involved in immune response (GO:0002323)8.57105397
3fructose metabolic process (GO:0006000)8.10768164
4digestive tract morphogenesis (GO:0048546)7.79258221
5cardiovascular system development (GO:0072358)7.54644921
6retina layer formation (GO:0010842)7.23637897
7regulation of helicase activity (GO:0051095)7.03036150
8positive regulation of SMAD protein import into nucleus (GO:0060391)6.93713519
9iron coordination entity transport (GO:1901678)6.15457992
10positive regulation of hair cycle (GO:0042635)6.02552337
11positive regulation of hair follicle development (GO:0051798)6.02552337
12regulation of SMAD protein import into nucleus (GO:0060390)5.84518289
13positive regulation of osteoblast proliferation (GO:0033690)5.50076946
14pre-miRNA processing (GO:0031054)5.46515889
15sodium-independent organic anion transport (GO:0043252)5.24748286
16angiogenesis involved in wound healing (GO:0060055)4.97866181
17DNA topological change (GO:0006265)4.92252885
18cellular response to dsRNA (GO:0071359)4.84744028
19calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.82214691
20regulation of interleukin-12 biosynthetic process (GO:0045075)4.79461962
21monoubiquitinated protein deubiquitination (GO:0035520)4.74482977
22negative regulation of defense response to virus (GO:0050687)4.68451531
23proximal/distal pattern formation (GO:0009954)4.47450378
24cerebellar granule cell differentiation (GO:0021707)4.46825763
25energy coupled proton transport, down electrochemical gradient (GO:0015985)4.40486654
26ATP synthesis coupled proton transport (GO:0015986)4.40486654
27pyrimidine ribonucleoside catabolic process (GO:0046133)4.35584878
28ovulation cycle (GO:0042698)4.34265565
29long-chain fatty acid biosynthetic process (GO:0042759)4.31936209
30positive regulation of smoothened signaling pathway (GO:0045880)4.29018060
31mating behavior (GO:0007617)4.27676027
32pituitary gland development (GO:0021983)4.25945714
33regulation of B cell receptor signaling pathway (GO:0050855)4.12731956
34phosphatidylglycerol biosynthetic process (GO:0006655)3.96432565
35phosphatidylethanolamine biosynthetic process (GO:0006646)3.94099489
36regulation of activation of Janus kinase activity (GO:0010533)3.93829386
37negative regulation of phagocytosis (GO:0050765)3.83935607
38CDP-diacylglycerol biosynthetic process (GO:0016024)3.83460743
39negative regulation of cell size (GO:0045792)3.83364984
40magnesium ion transport (GO:0015693)3.77071519
41regulation of apoptotic cell clearance (GO:2000425)3.72504243
42ncRNA catabolic process (GO:0034661)3.64548810
43positive regulation of regulated secretory pathway (GO:1903307)3.62663468
44regulation of defense response to virus by host (GO:0050691)3.62496024
45positive regulation of gastrulation (GO:2000543)3.62439802
46regulation of hair follicle development (GO:0051797)3.62177438
47ovulation from ovarian follicle (GO:0001542)3.61542297
48DNA integration (GO:0015074)3.56825639
49cell-cell junction maintenance (GO:0045217)3.56780052
50phosphatidylethanolamine metabolic process (GO:0046337)3.55902346
51carbohydrate phosphorylation (GO:0046835)3.50653699
52glycoprotein catabolic process (GO:0006516)3.46408009
53pattern specification involved in kidney development (GO:0061004)3.43864037
54leukocyte degranulation (GO:0043299)3.42706431
55nucleoside diphosphate catabolic process (GO:0009134)3.32207898
56regulation of mesoderm development (GO:2000380)3.31072272
57regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.26031734
58regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.24672111
59positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.23867931
60sulfur amino acid catabolic process (GO:0000098)3.22898578
61CDP-diacylglycerol metabolic process (GO:0046341)3.22151568
62melanosome transport (GO:0032402)3.19713556
63cell migration in hindbrain (GO:0021535)3.18026965
64lipoxygenase pathway (GO:0019372)3.17364019
65cell junction maintenance (GO:0034331)3.16741911
66peptidyl-lysine dimethylation (GO:0018027)3.15696208
67negative regulation of response to biotic stimulus (GO:0002832)3.12209414
68pyrimidine nucleotide catabolic process (GO:0006244)3.10706256
69histone H3-K36 demethylation (GO:0070544)3.09943002
70establishment of melanosome localization (GO:0032401)3.08266968
71regulation of cilium movement (GO:0003352)3.05919310
72regulation of Cdc42 GTPase activity (GO:0043088)3.05726842
73tolerance induction (GO:0002507)3.05590662
74pigment granule transport (GO:0051904)3.04151185
75melanocyte differentiation (GO:0030318)3.02150580
76platelet dense granule organization (GO:0060155)3.00862787
77regulation of gastrulation (GO:0010470)2.99720754
78negative regulation of B cell proliferation (GO:0030889)2.99431409
79positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.96546356
80dorsal/ventral pattern formation (GO:0009953)2.96192604
81filopodium assembly (GO:0046847)2.94978221
82positive regulation by host of viral transcription (GO:0043923)2.93912595
83establishment of pigment granule localization (GO:0051905)2.93878899
84nitric oxide mediated signal transduction (GO:0007263)2.93424082
85negative regulation of glial cell proliferation (GO:0060253)2.92245788
86embryonic heart tube development (GO:0035050)2.90378309
87response to exogenous dsRNA (GO:0043330)2.90332002
88positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.89212529
89endoderm formation (GO:0001706)2.85908713
90tyrosine phosphorylation of STAT protein (GO:0007260)2.84860473
91regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.84533235
92positive regulation of vesicle fusion (GO:0031340)2.83820221
93histone H3-K9 methylation (GO:0051567)2.83725512
94positive regulation of neurological system process (GO:0031646)2.81722566
95regulation of regulated secretory pathway (GO:1903305)2.79611206
96natural killer cell activation (GO:0030101)2.77912184
97mRNA transcription (GO:0009299)2.72905964
98melanosome localization (GO:0032400)2.71886364
99cytokine production involved in immune response (GO:0002367)2.69090985
100cellular response to exogenous dsRNA (GO:0071360)10.3917893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.99501393
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.29126457
3ESR1_15608294_ChIP-ChIP_MCF-7_Human2.97083933
4SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.92003233
5VDR_22108803_ChIP-Seq_LS180_Human2.64536988
6SRY_22984422_ChIP-ChIP_TESTIS_Rat2.63597731
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53819581
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41381675
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40089472
10DROSHA_22980978_ChIP-Seq_HELA_Human2.39584567
11ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.36595358
12RNF2_27304074_Chip-Seq_NSC_Mouse2.14220406
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.13811496
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.05730491
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02276378
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02276378
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01524826
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00124130
19ZNF274_21170338_ChIP-Seq_K562_Hela1.99844927
20CDX2_20551321_ChIP-Seq_CACO-2_Human1.99351834
21GBX2_23144817_ChIP-Seq_PC3_Human1.97764961
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.89995123
23EZH2_27294783_Chip-Seq_ESCs_Mouse1.77593166
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.74899441
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72389659
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.67665433
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67450776
28POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66483536
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66483536
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.66150186
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66147575
32GATA1_22025678_ChIP-Seq_K562_Human1.62516165
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61189892
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.58737764
35ETV2_25802403_ChIP-Seq_MESCs_Mouse1.57066046
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47445882
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.44875985
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40951870
39RING1B_27294783_Chip-Seq_NPCs_Mouse1.35631662
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34559580
41TAF2_19829295_ChIP-Seq_ESCs_Human1.34386602
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33660950
43SMAD3_21741376_ChIP-Seq_HESCs_Human1.30605808
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30250962
45EZH2_22144423_ChIP-Seq_EOC_Human1.30229751
46CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29116655
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29034119
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.26871374
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25948684
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.25794370
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25384810
52LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24534873
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17801089
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.16038952
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.14459407
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14314878
57JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12875401
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.12364393
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.08204984
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07128457
61ER_23166858_ChIP-Seq_MCF-7_Human1.06419445
62KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06298692
63KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06298692
64KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06298692
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05875464
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05306197
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03419963
68STAT3_18555785_Chip-Seq_ESCs_Mouse1.02435913
69P300_19829295_ChIP-Seq_ESCs_Human1.02380971
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.01959609
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00549981
72ERA_21632823_ChIP-Seq_H3396_Human0.99946490
73TP63_19390658_ChIP-ChIP_HaCaT_Human0.99913025
74IRF1_19129219_ChIP-ChIP_H3396_Human0.93447751
75LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.92879274
76SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92727161
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92086649
78RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91890026
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90421805
80SMAD3_21741376_ChIP-Seq_EPCs_Human0.90253786
81P53_21459846_ChIP-Seq_SAOS-2_Human0.87484505
82BCL6_27268052_Chip-Seq_Bcells_Human0.87368745
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86429865
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85947977
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84689628
86SMAD4_21741376_ChIP-Seq_HESCs_Human0.84655831
87STAT1_17558387_ChIP-Seq_HELA_Human0.84518933
88VDR_24787735_ChIP-Seq_THP-1_Human0.83411170
89NANOG_20526341_ChIP-Seq_ESCs_Human0.82750104
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82618486
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82588395
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82266582
93NCOR_22424771_ChIP-Seq_293T_Human0.81438688
94SMAD4_21741376_ChIP-Seq_EPCs_Human0.81279212
95MYC_19829295_ChIP-Seq_ESCs_Human0.81278226
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81239776
97STAT1_20625510_ChIP-Seq_HELA_Human0.80733505
98HIF1A_21447827_ChIP-Seq_MCF-7_Human0.80484002
99STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.79632446
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.78639882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog8.88859317
2MP0005084_abnormal_gallbladder_morpholo8.32934667
3MP0003252_abnormal_bile_duct5.12273214
4MP0002928_abnormal_bile_duct4.94097590
5MP0004133_heterotaxia4.19662094
6MP0000462_abnormal_digestive_system4.15591922
7MP0008995_early_reproductive_senescence3.33593552
8MP0005645_abnormal_hypothalamus_physiol2.82133876
9MP0003315_abnormal_perineum_morphology2.79937465
10MP0005408_hypopigmentation2.72900128
11MP0001919_abnormal_reproductive_system2.55975542
12MP0000631_abnormal_neuroendocrine_gland2.52363390
13MP0005220_abnormal_exocrine_pancreas2.23028668
14MP0001270_distended_abdomen2.09657591
15MP0005389_reproductive_system_phenotype1.99753267
16MP0002095_abnormal_skin_pigmentation1.83061040
17MP0005187_abnormal_penis_morphology1.75991080
18MP0005381_digestive/alimentary_phenotyp1.67637361
19MP0003283_abnormal_digestive_organ1.63296876
20MP0000371_diluted_coat_color1.62664228
21MP0008569_lethality_at_weaning1.51372762
22MP0003119_abnormal_digestive_system1.43727618
23MP0004019_abnormal_vitamin_homeostasis1.39794572
24MP0002909_abnormal_adrenal_gland1.24954658
25MP0008932_abnormal_embryonic_tissue1.24826831
26MP0002277_abnormal_respiratory_mucosa1.18993553
27MP0006292_abnormal_olfactory_placode1.18472964
28MP0005646_abnormal_pituitary_gland1.12341331
29MP0002160_abnormal_reproductive_system1.12175459
30MP0005503_abnormal_tendon_morphology1.10771412
31MP0003866_abnormal_defecation1.07760583
32MP0001501_abnormal_sleep_pattern1.06997437
33MP0003646_muscle_fatigue1.05592662
34MP0008260_abnormal_autophagy1.02497999
35MP0002136_abnormal_kidney_physiology0.90377201
36MP0009785_altered_susceptibility_to0.83838604
37MP0005083_abnormal_biliary_tract0.81408781
38MP0003195_calcinosis0.78122007
39MP0002653_abnormal_ependyma_morphology0.76411038
40MP0005464_abnormal_platelet_physiology0.75102769
41MP0005671_abnormal_response_to0.73342729
42MP0003936_abnormal_reproductive_system0.72604084
43MP0000013_abnormal_adipose_tissue0.70733218
44MP0001944_abnormal_pancreas_morphology0.70288629
45MP0009703_decreased_birth_body0.68850856
46MP0003879_abnormal_hair_cell0.67469105
47MP0008872_abnormal_physiological_respon0.67129924
48MP0002837_dystrophic_cardiac_calcinosis0.66970388
49MP0002127_abnormal_cardiovascular_syste0.66802676
50MP0001663_abnormal_digestive_system0.65656618
51MP0004043_abnormal_pH_regulation0.64571923
52MP0001756_abnormal_urination0.62936052
53MP0004858_abnormal_nervous_system0.61313523
54MP0001881_abnormal_mammary_gland0.58408942
55MP0008789_abnormal_olfactory_epithelium0.57756432
56MP0000049_abnormal_middle_ear0.56243652
57MP0009333_abnormal_splenocyte_physiolog0.56092002
58MP0002166_altered_tumor_susceptibility0.55129638
59MP0000647_abnormal_sebaceous_gland0.54517850
60MP0002075_abnormal_coat/hair_pigmentati0.54488080
61MP0004883_abnormal_blood_vessel0.53316037
62MP0003828_pulmonary_edema0.52245086
63MP0003942_abnormal_urinary_system0.52199286
64MP0003786_premature_aging0.51913472
65MP0002163_abnormal_gland_morphology0.51767624
66MP0001502_abnormal_circadian_rhythm0.51585869
67MP0002557_abnormal_social/conspecific_i0.51334158
68MP0005551_abnormal_eye_electrophysiolog0.51239985
69MP0005410_abnormal_fertilization0.51024842
70MP0002102_abnormal_ear_morphology0.50682216
71MP0005387_immune_system_phenotype0.49905571
72MP0001790_abnormal_immune_system0.49905571
73MP0000372_irregular_coat_pigmentation0.48977287
74MP0009745_abnormal_behavioral_response0.48592768
75MP0000955_abnormal_spinal_cord0.47371330
76MP0002108_abnormal_muscle_morphology0.46542273
77MP0000639_abnormal_adrenal_gland0.45264989
78MP0002067_abnormal_sensory_capabilities0.44745651
79MP0010386_abnormal_urinary_bladder0.44273861
80MP0002234_abnormal_pharynx_morphology0.42939061
81MP0001986_abnormal_taste_sensitivity0.42672777
82MP0002184_abnormal_innervation0.42573584
83MP0001873_stomach_inflammation0.42175935
84MP0002006_tumorigenesis0.42064350
85MP0005025_abnormal_response_to0.41937559
86MP0002572_abnormal_emotion/affect_behav0.40333841
87MP0005379_endocrine/exocrine_gland_phen0.40135620
88MP0000467_abnormal_esophagus_morphology0.38936282
89MP0002135_abnormal_kidney_morphology0.37756161
90MP0002736_abnormal_nociception_after0.37561995
91MP0000627_abnormal_mammary_gland0.37264532
92MP0004197_abnormal_fetal_growth/weight/0.36829894
93MP0003984_embryonic_growth_retardation0.36747312
94MP0000490_abnormal_crypts_of0.36352919
95MP0004084_abnormal_cardiac_muscle0.35881067
96MP0000653_abnormal_sex_gland0.35250557
97MP0009643_abnormal_urine_homeostasis0.35188352
98MP0008775_abnormal_heart_ventricle0.34976210
99MP0003938_abnormal_ear_development0.34566224
100MP0010329_abnormal_lipoprotein_level0.34524730

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the tracheobronchial system (HP:0100552)9.80972870
2Tetany (HP:0001281)6.44409099
3Hypomagnesemia (HP:0002917)6.29323177
4Abnormal delayed hypersensitivity skin test (HP:0002963)5.68015241
5Abnormality of magnesium homeostasis (HP:0004921)5.12172405
6Abnormal drinking behavior (HP:0030082)4.98332941
7Polydipsia (HP:0001959)4.98332941
8Ependymoma (HP:0002888)4.93948937
9Neoplasm of the heart (HP:0100544)4.87925160
10Pulmonary infiltrates (HP:0002113)4.47950874
11Generalized hypopigmentation of hair (HP:0011358)4.27969405
12Neoplasm of the lung (HP:0100526)4.05477714
13Lymphangioma (HP:0100764)3.95107018
14Synostosis involving the elbow (HP:0003938)3.72762920
15Humeroradial synostosis (HP:0003041)3.72762920
16Neoplasm of the respiratory system (HP:0100606)3.58427561
17Polyuria (HP:0000103)3.57538252
18Abnormality of purine metabolism (HP:0004352)3.49232990
19Abnormality of the astrocytes (HP:0100707)3.44065715
20Astrocytoma (HP:0009592)3.44065715
21Bronchomalacia (HP:0002780)3.38011923
22Hemiplegia (HP:0002301)3.18840291
23Renal tubular acidosis (HP:0001947)3.17413463
24Tracheomalacia (HP:0002779)3.17099437
25Increased purine levels (HP:0004368)3.14844697
26Hyperuricemia (HP:0002149)3.14844697
27Progressive neurologic deterioration (HP:0002344)3.12719077
28Abnormal urine output (HP:0012590)3.06714022
29Congenital, generalized hypertrichosis (HP:0004540)2.98713416
30Fibular aplasia (HP:0002990)2.97873654
31Ocular albinism (HP:0001107)2.87962242
32Hypothermia (HP:0002045)2.76676495
33Glioma (HP:0009733)2.73742431
34Abnormality of the axillary hair (HP:0100134)2.72661105
35Abnormality of secondary sexual hair (HP:0009888)2.72661105
36Premature graying of hair (HP:0002216)2.72198782
37Abnormality of the vertebral endplates (HP:0005106)2.64017447
38Symphalangism affecting the phalanges of the hand (HP:0009773)2.60435487
39Persistence of primary teeth (HP:0006335)2.59094971
40Abnormality of renal excretion (HP:0011036)2.57648109
41Iris hypopigmentation (HP:0007730)2.56315660
42Thyroid-stimulating hormone excess (HP:0002925)2.54052744
43Abnormality of T cell physiology (HP:0011840)2.45618969
44Split foot (HP:0001839)2.43072231
45Agitation (HP:0000713)2.39076861
46Increased serum ferritin (HP:0003281)2.38092512
47Abnormality of nucleobase metabolism (HP:0010932)2.37354553
48Infantile muscular hypotonia (HP:0008947)2.33703800
49Abnormal sex determination (HP:0012244)2.32088187
50Sex reversal (HP:0012245)2.32088187
51Conical tooth (HP:0000698)2.29929701
52Hamartoma of the eye (HP:0010568)2.28658443
53Skin nodule (HP:0200036)2.18413034
54Enlarged epiphyses (HP:0010580)2.17199485
55Congenital stationary night blindness (HP:0007642)2.12375316
56Hemangiomatosis (HP:0007461)2.09363338
57Flattened epiphyses (HP:0003071)2.08596361
58Visceral angiomatosis (HP:0100761)2.06431940
59Renal tubular dysfunction (HP:0000124)2.03371693
60Spinal muscular atrophy (HP:0007269)2.02785101
61Abnormality of iron homeostasis (HP:0011031)2.02426551
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01066738
63Alveolar cell carcinoma (HP:0006519)10.7298752
64Oligodactyly (hands) (HP:0001180)1.97841105
65Meningitis (HP:0001287)1.95756045
66Mitral stenosis (HP:0001718)1.91968581
67Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.91220524
68Hypopigmentation of the fundus (HP:0007894)1.88753134
69Apathy (HP:0000741)1.87586551
70Dialeptic seizures (HP:0011146)1.87408547
71Neoplasm of striated muscle (HP:0009728)1.86642450
72Broad ribs (HP:0000885)1.85166081
73Natal tooth (HP:0000695)1.84950758
74Microglossia (HP:0000171)1.84878330
75Abnormality of transition element cation homeostasis (HP:0011030)1.84796105
76Polygenic inheritance (HP:0010982)1.83784721
77Molar tooth sign on MRI (HP:0002419)1.82068472
78Abnormality of midbrain morphology (HP:0002418)1.82068472
79Hemiparesis (HP:0001269)1.80131263
80Stridor (HP:0010307)1.79465922
81Death in childhood (HP:0003819)1.76773577
82Hemoptysis (HP:0002105)1.75761900
83Hematuria (HP:0000790)1.75592786
84Stomach cancer (HP:0012126)1.73343393
85Atelectasis (HP:0100750)1.73117817
86Hypercalciuria (HP:0002150)1.69925167
87Abnormality of sulfur amino acid metabolism (HP:0004339)1.69081529
88Abnormality of the anterior horn cell (HP:0006802)1.68940365
89Degeneration of anterior horn cells (HP:0002398)1.68940365
90Elevated erythrocyte sedimentation rate (HP:0003565)1.68040603
91Weak cry (HP:0001612)1.67880581
92Diaphragmatic weakness (HP:0009113)1.67431853
93Diminished motivation (HP:0000745)1.67045732
94Gingivitis (HP:0000230)1.66022611
95Abnormality of T cells (HP:0002843)1.64404861
96Focal segmental glomerulosclerosis (HP:0000097)1.64150175
97Macroglossia (HP:0000158)1.63723577
98Anal stenosis (HP:0002025)1.63265087
99Rectal fistula (HP:0100590)1.62877207
100Rectovaginal fistula (HP:0000143)1.62877207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAF18.27761932
2STK38L5.38725402
3STK244.74932223
4PRKCI4.60137156
5MAP3K53.29787595
6BLK2.64853705
7CAMK1D2.52562501
8TLK12.50145179
9MAPK152.40337122
10TAOK32.11209652
11MATK1.99071972
12JAK31.87929034
13TEC1.78974395
14ITK1.78540849
15CAMK1G1.74281460
16TRIB31.57684455
17INSRR1.52978155
18CAMK11.47914537
19CAMK41.42649092
20PTK61.32522728
21IKBKB1.18672739
22ERBB21.16721156
23ADRBK21.08712326
24STK31.06027272
25PLK41.00963834
26MAP4K20.94151946
27SYK0.91314335
28ZAK0.91031282
29TIE10.89664414
30WNK40.86822591
31TXK0.86517119
32BMPR1B0.82807024
33MAP3K140.82421202
34GRK10.79832851
35STK160.76141351
36IKBKE0.74936581
37ERBB40.73527623
38STK390.72044963
39AKT30.71881833
40MKNK20.68400122
41BTK0.66740322
42VRK10.66567804
43MAP3K40.66501926
44KIT0.64692613
45OXSR10.59756946
46OBSCN0.59480401
47CSF1R0.58681456
48CDK30.56407951
49FRK0.56377195
50WNK30.56372728
51CSK0.56231982
52NTRK20.55920536
53NME10.54712790
54EIF2AK20.54468874
55MAP2K70.54031445
56PKN10.53770604
57PHKG10.51622018
58PHKG20.51622018
59PINK10.49476909
60CAMK2A0.47593117
61TSSK60.46314019
62RPS6KA60.43900797
63CSNK1A10.43399234
64BCKDK0.42823947
65PAK30.40679785
66NTRK10.40649804
67CHUK0.40319759
68PRKCZ0.39428715
69RPS6KC10.38938494
70RPS6KL10.38938494
71EPHA20.38682944
72PRKAA10.37793327
73LYN0.37368845
74PRKCG0.36119844
75MKNK10.35764624
76MET0.35456208
77RPS6KA20.34139316
78MAPKAPK50.32508129
79IGF1R0.32291830
80ATR0.32025151
81MUSK0.31091675
82TRIM280.31079607
83KDR0.30718974
84TBK10.30438503
85ACVR1B0.30173235
86CSNK2A10.30158447
87AKT10.28826033
88IRAK40.28609038
89PRKACA0.28253805
90TGFBR10.24921840
91LCK0.24757630
92INSR0.24290878
93CDK70.23646183
94PRKCQ0.23568362
95MAPK70.23543026
96PRKAA20.23374106
97FGFR20.21563420
98ATM0.21460090
99PRKG10.20961082
100PRKCD0.18963192

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.96945472
2Sulfur metabolism_Homo sapiens_hsa009203.51512103
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.47756602
4Hedgehog signaling pathway_Homo sapiens_hsa043403.31200071
5Homologous recombination_Homo sapiens_hsa034403.25250659
6Basal cell carcinoma_Homo sapiens_hsa052172.78732676
7Fructose and mannose metabolism_Homo sapiens_hsa000512.74162733
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.60692046
9Salivary secretion_Homo sapiens_hsa049702.26917008
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.06962319
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05109612
12Arachidonic acid metabolism_Homo sapiens_hsa005901.97523311
13Asthma_Homo sapiens_hsa053101.95838429
14African trypanosomiasis_Homo sapiens_hsa051431.87084624
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.86349198
16Nitrogen metabolism_Homo sapiens_hsa009101.84702140
17Phototransduction_Homo sapiens_hsa047441.80938825
18Caffeine metabolism_Homo sapiens_hsa002321.70828718
19Fanconi anemia pathway_Homo sapiens_hsa034601.58075349
20Autoimmune thyroid disease_Homo sapiens_hsa053201.53092097
21Arginine biosynthesis_Homo sapiens_hsa002201.51160818
22Allograft rejection_Homo sapiens_hsa053301.49722158
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48240764
24Graft-versus-host disease_Homo sapiens_hsa053321.46085502
25Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.42067508
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.26172179
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24405417
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.22475692
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21656649
30Type I diabetes mellitus_Homo sapiens_hsa049401.21050461
31Oxidative phosphorylation_Homo sapiens_hsa001901.20760080
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19726444
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13415571
34Starch and sucrose metabolism_Homo sapiens_hsa005001.12488293
35Basal transcription factors_Homo sapiens_hsa030221.10472344
36Parkinsons disease_Homo sapiens_hsa050121.08230137
37Regulation of autophagy_Homo sapiens_hsa041401.07740927
38Systemic lupus erythematosus_Homo sapiens_hsa053221.05540867
39Retinol metabolism_Homo sapiens_hsa008301.03963093
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01354064
41Hepatitis C_Homo sapiens_hsa051600.99785086
42Complement and coagulation cascades_Homo sapiens_hsa046100.99150967
43Staphylococcus aureus infection_Homo sapiens_hsa051500.98631879
44Taste transduction_Homo sapiens_hsa047420.97460848
45Chemical carcinogenesis_Homo sapiens_hsa052040.94730290
46Olfactory transduction_Homo sapiens_hsa047400.91866751
47Glycerophospholipid metabolism_Homo sapiens_hsa005640.91520546
48Leishmaniasis_Homo sapiens_hsa051400.87600063
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87541804
50Herpes simplex infection_Homo sapiens_hsa051680.84649196
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82883013
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81685409
53Serotonergic synapse_Homo sapiens_hsa047260.81275865
54Galactose metabolism_Homo sapiens_hsa000520.81222804
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78341740
56cAMP signaling pathway_Homo sapiens_hsa040240.78055192
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77667735
58Other glycan degradation_Homo sapiens_hsa005110.77105846
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76737204
60Fat digestion and absorption_Homo sapiens_hsa049750.73996595
61Huntingtons disease_Homo sapiens_hsa050160.70906413
62Ovarian steroidogenesis_Homo sapiens_hsa049130.69100734
63Nicotine addiction_Homo sapiens_hsa050330.69050425
64Rheumatoid arthritis_Homo sapiens_hsa053230.66673005
65Ether lipid metabolism_Homo sapiens_hsa005650.62961696
66One carbon pool by folate_Homo sapiens_hsa006700.62354517
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56878906
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.56153737
69mTOR signaling pathway_Homo sapiens_hsa041500.55730271
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55092890
71AMPK signaling pathway_Homo sapiens_hsa041520.51901249
72Antigen processing and presentation_Homo sapiens_hsa046120.51242320
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.50130244
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49986266
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49299118
76Protein digestion and absorption_Homo sapiens_hsa049740.47480847
77Hematopoietic cell lineage_Homo sapiens_hsa046400.47344682
78Ribosome_Homo sapiens_hsa030100.47164004
79Cardiac muscle contraction_Homo sapiens_hsa042600.45474778
80ECM-receptor interaction_Homo sapiens_hsa045120.44206714
81Primary immunodeficiency_Homo sapiens_hsa053400.43188305
82Sphingolipid metabolism_Homo sapiens_hsa006000.41782113
83Alzheimers disease_Homo sapiens_hsa050100.41380379
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40539535
85Circadian entrainment_Homo sapiens_hsa047130.39041647
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38300206
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37931321
88Cocaine addiction_Homo sapiens_hsa050300.37344698
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36425891
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.36093516
91Morphine addiction_Homo sapiens_hsa050320.36040354
92Long-term depression_Homo sapiens_hsa047300.31840739
93Vitamin digestion and absorption_Homo sapiens_hsa049770.31555794
94Fatty acid biosynthesis_Homo sapiens_hsa000610.28775452
95Amphetamine addiction_Homo sapiens_hsa050310.26272215
96Tryptophan metabolism_Homo sapiens_hsa003800.24646288
97Notch signaling pathway_Homo sapiens_hsa043300.24325759
98MAPK signaling pathway_Homo sapiens_hsa040100.23937356
99Purine metabolism_Homo sapiens_hsa002300.23509396
100Tyrosine metabolism_Homo sapiens_hsa003500.23396115

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