ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.95304215
2	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	6.68915262
3	cytidine deamination (GO:0009972)	5.65674849
4	cytidine metabolic process (GO:0046087)	5.65674849
5	cytidine catabolic process (GO:0006216)	5.65674849
6	response to pheromone (GO:0019236)	5.29539082
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.76427972
8	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.76427972
9	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.68293758
10	T cell migration (GO:0072678)	4.19386690
11	GTP biosynthetic process (GO:0006183)	4.05888007
12	negative regulation of nitric-oxide synthase activity (GO:0051001)	4.03391810
13	DNA demethylation (GO:0080111)	3.92143071
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.79550460
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.79550460
16	NADH dehydrogenase complex assembly (GO:0010257)	3.79550460
17	aldehyde catabolic process (GO:0046185)	3.71083446
18	nucleoside diphosphate phosphorylation (GO:0006165)	3.70599584
19	piRNA metabolic process (GO:0034587)	3.67423365
20	protein complex biogenesis (GO:0070271)	3.63248826
21	platelet dense granule organization (GO:0060155)	3.50570269
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.41882641
23	regulation of immunoglobulin secretion (GO:0051023)	3.34842973
24	peptidyl-histidine modification (GO:0018202)	3.34744009
25	regulation of sarcomere organization (GO:0060297)	3.30266360
26	positive regulation of defense response to virus by host (GO:0002230)	3.25902869
27	adaptation of signaling pathway (GO:0023058)	3.24789294
28	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	3.19995394
29	UTP biosynthetic process (GO:0006228)	3.18911761
30	mitochondrial respiratory chain complex assembly (GO:0033108)	3.13112746
31	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.12962978
32	ATP synthesis coupled proton transport (GO:0015986)	3.12552609
33	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.12552609
34	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	3.11883337
35	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.09901612
36	UTP metabolic process (GO:0046051)	3.08503068
37	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.05340424
38	zinc ion homeostasis (GO:0055069)	3.05285744
39	water-soluble vitamin biosynthetic process (GO:0042364)	3.02400006
40	negative T cell selection (GO:0043383)	2.97077633
41	regulation of isotype switching to IgG isotypes (GO:0048302)	2.94683730
42	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.94025132
43	regulation of B cell receptor signaling pathway (GO:0050855)	2.92963188
44	regulation of T-helper 1 type immune response (GO:0002825)	2.92803519
45	negative regulation by host of viral transcription (GO:0043922)	2.92373152
46	negative regulation of execution phase of apoptosis (GO:1900118)	2.92027170
47	chaperone-mediated protein transport (GO:0072321)	2.91266827
48	DNA dealkylation (GO:0035510)	2.91264816
49	ribonucleoprotein complex disassembly (GO:0032988)	2.89321646
50	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.89286195
51	negative regulation of telomere maintenance (GO:0032205)	2.87402944
52	actin nucleation (GO:0045010)	2.83455742
53	axoneme assembly (GO:0035082)	2.81444065
54	pantothenate metabolic process (GO:0015939)	2.81388629
55	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.78871189
56	regulation of chronic inflammatory response (GO:0002676)	2.78432204
57	single strand break repair (GO:0000012)	2.77151116
58	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.76294487
59	negative regulation of monooxygenase activity (GO:0032769)	2.76247660
60	intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)	2.76142896
61	positive T cell selection (GO:0043368)	2.76012922
62	protein neddylation (GO:0045116)	2.73472275
63	sequestering of actin monomers (GO:0042989)	2.72330751
64	regulation of skeletal muscle contraction (GO:0014819)	2.70695065
65	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.70111694
66	adenosine metabolic process (GO:0046085)	2.69475904
67	positive regulation of T-helper 1 type immune response (GO:0002827)	2.68104332
68	respiratory chain complex IV assembly (GO:0008535)	2.65514356
69	protein polyglutamylation (GO:0018095)	2.64604852
70	coenzyme A biosynthetic process (GO:0015937)	2.64324234
71	regulation of action potential (GO:0098900)	2.63586433
72	DNA methylation involved in gamete generation (GO:0043046)	2.63193767
73	negative regulation of oxidoreductase activity (GO:0051354)	2.61579481
74	forebrain morphogenesis (GO:0048853)	2.58898780
75	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.58039634
76	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.57604200
77	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.57604200
78	dopamine transport (GO:0015872)	2.55993260
79	negative regulation of systemic arterial blood pressure (GO:0003085)	2.55316563
80	positive regulation of cAMP-mediated signaling (GO:0043950)	2.53620038
81	guanosine-containing compound biosynthetic process (GO:1901070)	2.51490214
82	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.49734866
83	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.49587943
84	lymphocyte chemotaxis (GO:0048247)	2.47788169
85	positive regulation of monocyte chemotaxis (GO:0090026)	2.46860959
86	primary alcohol catabolic process (GO:0034310)	2.44287851
87	response to interferon-beta (GO:0035456)	2.43951140
88	proteasome assembly (GO:0043248)	2.42832480
89	cytochrome complex assembly (GO:0017004)	2.41369846
90	cell fate commitment involved in formation of primary germ layer (GO:0060795)	2.38424162
91	positive regulation of calcium-mediated signaling (GO:0050850)	2.37521607
92	electron transport chain (GO:0022900)	2.34611923
93	protein-cofactor linkage (GO:0018065)	2.33567095
94	regulation of activation of Janus kinase activity (GO:0010533)	2.32000256
95	respiratory electron transport chain (GO:0022904)	2.31855779
96	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.30847766
97	negative regulation of viral genome replication (GO:0045071)	2.30348003
98	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.30285155
99	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.29780840
100	positive thymic T cell selection (GO:0045059)	2.29604577

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.20631487
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.04033248
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.82372439
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.76601983
5	GATA1_22025678_ChIP-Seq_K562_Human	3.64630543
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.41973515
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.41163337
8	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.06917219
9	VDR_22108803_ChIP-Seq_LS180_Human	2.90296970
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.64525276
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.64198203
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.60952620
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.58538005
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.49134660
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.41864181
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.21314549
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.18634396
18	FUS_26573619_Chip-Seq_HEK293_Human	2.17386212
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.06028418
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.91062395
21	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.90194103
22	EWS_26573619_Chip-Seq_HEK293_Human	1.88993747
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.79907159
24	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.77294902
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.77104540
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.73146282
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72177900
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71507665
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67912160
30	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.64912756
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.64632710
32	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.64326570
33	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63842006
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63537902
35	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.61281866
36	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.60946162
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.60195820
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.56980879
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.56552374
40	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.56029740
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.54923991
42	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46643674
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.43676336
44	P300_19829295_ChIP-Seq_ESCs_Human	1.43145259
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.42755216
46	GATA3_26560356_Chip-Seq_TH2_Human	1.40249180
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.39835549
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.36818311
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36038938
50	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29814345
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29455685
52	MYB_26560356_Chip-Seq_TH2_Human	1.25029287
53	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.17460481
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14603507
55	AR_20517297_ChIP-Seq_VCAP_Human	1.14090826
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13682656
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13682656
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.13143087
59	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12058402
60	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.12024004
61	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.11370205
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.08101926
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.08101926
64	AR_21572438_ChIP-Seq_LNCaP_Human	1.07942236
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06706281
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06478051
67	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05494430
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05318434
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05095824
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03688950
71	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.03079295
72	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.02146250
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00521877
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00521877
75	BCAT_22108803_ChIP-Seq_LS180_Human	1.00311567
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98168014
77	IRF1_19129219_ChIP-ChIP_H3396_Human	0.97770117
78	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97749857
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96816180
80	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.96477165
81	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.95422077
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95253183
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.94259338
84	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.93532665
85	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.93355898
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.92363617
87	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.91530495
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.90968772
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.90695150
90	JUN_21703547_ChIP-Seq_K562_Human	0.90186920
91	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.90142309
92	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.88930117
93	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.88882962
94	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.87373982
95	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.86719386
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.86645470
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.86574048
98	GATA3_27048872_Chip-Seq_THYMUS_Human	0.85103766
99	TCF4_22108803_ChIP-Seq_LS180_Human	0.84850679
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84724508

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.33671874
2	MP0005671_abnormal_response_to	3.21720027
3	MP0002138_abnormal_hepatobiliary_system	2.68232067
4	MP0002837_dystrophic_cardiac_calcinosis	2.61516098
5	MP0008872_abnormal_physiological_respon	2.56756613
6	MP0009785_altered_susceptibility_to	2.52241778
7	MP0006072_abnormal_retinal_apoptosis	2.34603270
8	MP0005646_abnormal_pituitary_gland	2.13548826
9	MP0008995_early_reproductive_senescence	2.11572097
10	MP0003183_abnormal_peptide_metabolism	2.03042662
11	MP0000569_abnormal_digit_pigmentation	1.98950892
12	MP0006292_abnormal_olfactory_placode	1.98750223
13	MP0005377_hearing/vestibular/ear_phenot	1.95247839
14	MP0003878_abnormal_ear_physiology	1.95247839
15	MP0004145_abnormal_muscle_electrophysio	1.91637072
16	MP0001485_abnormal_pinna_reflex	1.87378333
17	MP0001984_abnormal_olfaction	1.86996742
18	MP0006082_CNS_inflammation	1.86699165
19	MP0001873_stomach_inflammation	1.83279932
20	MP0005645_abnormal_hypothalamus_physiol	1.82802056
21	MP0003786_premature_aging	1.75872053
22	MP0008789_abnormal_olfactory_epithelium	1.72499069
23	MP0002095_abnormal_skin_pigmentation	1.71919634
24	MP0004142_abnormal_muscle_tone	1.71576241
25	MP0008877_abnormal_DNA_methylation	1.65670890
26	MP0002876_abnormal_thyroid_physiology	1.65169235
27	MP0004742_abnormal_vestibular_system	1.65047192
28	MP0003950_abnormal_plasma_membrane	1.63472712
29	MP0005623_abnormal_meninges_morphology	1.62694556
30	MP0001542_abnormal_bone_strength	1.61952778
31	MP0004885_abnormal_endolymph	1.58894471
32	MP0001529_abnormal_vocalization	1.55766642
33	MP0000749_muscle_degeneration	1.54166693
34	MP0005174_abnormal_tail_pigmentation	1.54090990
35	MP0003718_maternal_effect	1.52991986
36	MP0005551_abnormal_eye_electrophysiolog	1.43107679
37	MP0002166_altered_tumor_susceptibility	1.40998300
38	MP0003646_muscle_fatigue	1.37691061
39	MP0001835_abnormal_antigen_presentation	1.33040472
40	MP0002148_abnormal_hypersensitivity_rea	1.32295407
41	MP0001800_abnormal_humoral_immune	1.31504556
42	MP0005075_abnormal_melanosome_morpholog	1.30852606
43	MP0008875_abnormal_xenobiotic_pharmacok	1.26459304
44	MP0005187_abnormal_penis_morphology	1.24598782
45	MP0000685_abnormal_immune_system	1.24356010
46	MP0003252_abnormal_bile_duct	1.20615492
47	MP0001905_abnormal_dopamine_level	1.18765274
48	MP0005499_abnormal_olfactory_system	1.17135299
49	MP0005394_taste/olfaction_phenotype	1.17135299
50	MP0001293_anophthalmia	1.16163783
51	MP0003866_abnormal_defecation	1.15959822
52	MP0003763_abnormal_thymus_physiology	1.13468208
53	MP0002163_abnormal_gland_morphology	1.08404939
54	MP0002254_reproductive_system_inflammat	1.06170616
55	MP0001764_abnormal_homeostasis	1.05513352
56	MP0003880_abnormal_central_pattern	1.05502695
57	MP0002723_abnormal_immune_serum	1.05337153
58	MP0009379_abnormal_foot_pigmentation	1.04019311
59	MP0001968_abnormal_touch/_nociception	1.04003296
60	MP0003938_abnormal_ear_development	1.03905780
61	MP0002277_abnormal_respiratory_mucosa	0.99689291
62	MP0002736_abnormal_nociception_after	0.98759257
63	MP0000015_abnormal_ear_pigmentation	0.98477388
64	MP0000372_irregular_coat_pigmentation	0.94686811
65	MP0001486_abnormal_startle_reflex	0.94612117
66	MP0005389_reproductive_system_phenotype	0.94501184
67	MP0002638_abnormal_pupillary_reflex	0.92734528
68	MP0001919_abnormal_reproductive_system	0.92087720
69	MP0005253_abnormal_eye_physiology	0.91038260
70	MP0002006_tumorigenesis	0.90659085
71	MP0003045_fibrosis	0.87621880
72	MP0004883_abnormal_blood_vessel	0.86917791
73	MP0004215_abnormal_myocardial_fiber	0.84049694
74	MP0005166_decreased_susceptibility_to	0.83457534
75	MP0005410_abnormal_fertilization	0.82958008
76	MP0002420_abnormal_adaptive_immunity	0.80763044
77	MP0003693_abnormal_embryo_hatching	0.80717381
78	MP0005084_abnormal_gallbladder_morpholo	0.80621750
79	MP0000230_abnormal_systemic_arterial	0.79219643
80	MP0000631_abnormal_neuroendocrine_gland	0.78807014
81	MP0005025_abnormal_response_to	0.78553945
82	MP0002751_abnormal_autonomic_nervous	0.78404558
83	MP0005636_abnormal_mineral_homeostasis	0.78397778
84	MP0003656_abnormal_erythrocyte_physiolo	0.78289484
85	MP0003724_increased_susceptibility_to	0.77962943
86	MP0001819_abnormal_immune_cell	0.77811179
87	MP0000026_abnormal_inner_ear	0.77549563
88	MP0000427_abnormal_hair_cycle	0.76940294
89	MP0002938_white_spotting	0.75854683
90	MP0002405_respiratory_system_inflammati	0.75336750
91	MP0004924_abnormal_behavior	0.75002043
92	MP0005386_behavior/neurological_phenoty	0.75002043
93	MP0002234_abnormal_pharynx_morphology	0.74199579
94	MP0005670_abnormal_white_adipose	0.73036163
95	MP0002272_abnormal_nervous_system	0.72909415
96	MP0002160_abnormal_reproductive_system	0.72012587
97	MP0009765_abnormal_xenobiotic_induced	0.71867619
98	MP0002452_abnormal_antigen_presenting	0.71626043
99	MP0005000_abnormal_immune_tolerance	0.70252642
100	MP0000639_abnormal_adrenal_gland	0.69458270

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.23189330
2	Renal cortical cysts (HP:0000803)	3.74501766
3	Calf muscle hypertrophy (HP:0008981)	3.60599087
4	Hypoproteinemia (HP:0003075)	3.43381499
5	T lymphocytopenia (HP:0005403)	3.33639098
6	Congenital stationary night blindness (HP:0007642)	3.28385867
7	Abnormality of the left ventricular outflow tract (HP:0011103)	3.26405900
8	Subaortic stenosis (HP:0001682)	3.26405900
9	Pancreatic fibrosis (HP:0100732)	3.23022338
10	Pancreatic cysts (HP:0001737)	3.16714676
11	Abolished electroretinogram (ERG) (HP:0000550)	3.13596149
12	Hypoalbuminemia (HP:0003073)	3.12239907
13	Abnormal albumin level (HP:0012116)	3.12239907
14	Muscle hypertrophy of the lower extremities (HP:0008968)	3.10741663
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.09929886
16	Neonatal respiratory distress (HP:0002643)	3.01271059
17	Stomatitis (HP:0010280)	2.93942494
18	Abnormality of T cell number (HP:0011839)	2.91832750
19	Abnormality of placental membranes (HP:0011409)	2.85620480
20	Amniotic constriction ring (HP:0009775)	2.85620480
21	True hermaphroditism (HP:0010459)	2.85373299
22	Abnormality of glycolysis (HP:0004366)	2.83912860
23	Medial flaring of the eyebrow (HP:0010747)	2.82645072
24	Hypoplasia of the thymus (HP:0000778)	2.78922632
25	Renal Fanconi syndrome (HP:0001994)	2.78026415
26	Type II lissencephaly (HP:0007260)	2.76383941
27	Constricted visual fields (HP:0001133)	2.72061693
28	Molar tooth sign on MRI (HP:0002419)	2.71591982
29	Abnormality of midbrain morphology (HP:0002418)	2.71591982
30	Increased hepatocellular lipid droplets (HP:0006565)	2.71463398
31	Prostate neoplasm (HP:0100787)	2.71396804
32	Abnormality of the renal cortex (HP:0011035)	2.70148996
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.69677290
34	Abnormality of macular pigmentation (HP:0008002)	2.68259579
35	Severe combined immunodeficiency (HP:0004430)	2.67152450
36	3-Methylglutaconic aciduria (HP:0003535)	2.65322885
37	Oral leukoplakia (HP:0002745)	2.60630795
38	Mitochondrial inheritance (HP:0001427)	2.60002995
39	Abnormality of the prostate (HP:0008775)	2.59822965
40	Lipid accumulation in hepatocytes (HP:0006561)	2.56532779
41	Mesangial abnormality (HP:0001966)	2.49524340
42	Hepatocellular necrosis (HP:0001404)	2.48915493
43	Cholecystitis (HP:0001082)	2.35115866
44	Abnormal gallbladder physiology (HP:0012438)	2.35115866
45	Optic disc pallor (HP:0000543)	2.28239216
46	Hypothermia (HP:0002045)	2.26977243
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.24845896
48	Acute necrotizing encephalopathy (HP:0006965)	2.24740248
49	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.24184207
50	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.24184207
51	Tubular atrophy (HP:0000092)	2.23664985
52	Elevated erythrocyte sedimentation rate (HP:0003565)	2.22298732
53	Thoracolumbar scoliosis (HP:0002944)	2.22240892
54	Increased CSF lactate (HP:0002490)	2.22213114
55	Chronic hepatic failure (HP:0100626)	2.20780402
56	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.19322767
57	Attenuation of retinal blood vessels (HP:0007843)	2.18368381
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.17745601
59	Abnormality of alanine metabolism (HP:0010916)	2.17745601
60	Hyperalaninemia (HP:0003348)	2.17745601
61	Exertional dyspnea (HP:0002875)	2.17217531
62	Hepatic necrosis (HP:0002605)	2.16324326
63	Short tibia (HP:0005736)	2.14971856
64	Pendular nystagmus (HP:0012043)	2.13487484
65	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.13033247
66	Stomach cancer (HP:0012126)	2.12461317
67	Progressive inability to walk (HP:0002505)	2.09661587
68	Impaired proprioception (HP:0010831)	2.09391288
69	Generalized aminoaciduria (HP:0002909)	2.08411534
70	Lactic acidosis (HP:0003128)	2.07922941
71	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07761474
72	Aplasia/hypoplasia of the uterus (HP:0008684)	2.04210841
73	Palpebral edema (HP:0100540)	2.02395750
74	Metaphyseal dysplasia (HP:0100255)	2.02336854
75	J-shaped sella turcica (HP:0002680)	2.01935084
76	Congenital primary aphakia (HP:0007707)	2.00355729
77	Progressive macrocephaly (HP:0004481)	1.99996235
78	Facial hemangioma (HP:0000329)	1.96465718
79	Increased intramyocellular lipid droplets (HP:0012240)	1.96057769
80	Cystic liver disease (HP:0006706)	1.95610919
81	Thyroiditis (HP:0100646)	1.95464194
82	Abnormality of T cells (HP:0002843)	1.95379109
83	IgG deficiency (HP:0004315)	1.93600375
84	Inability to walk (HP:0002540)	1.92599246
85	Exercise-induced muscle cramps (HP:0003710)	1.92093000
86	Gait imbalance (HP:0002141)	1.91915506
87	Nephrogenic diabetes insipidus (HP:0009806)	1.91410804
88	Nephronophthisis (HP:0000090)	1.91121320
89	Increased serum lactate (HP:0002151)	1.90302659
90	Reduced antithrombin III activity (HP:0001976)	1.89573357
91	Colon cancer (HP:0003003)	1.86920040
92	Abnormality of the middle phalanges of the toes (HP:0010183)	1.85348681
93	Hyperglycinemia (HP:0002154)	1.84801412
94	Abnormal mitochondria in muscle tissue (HP:0008316)	1.84420338
95	Abnormal drinking behavior (HP:0030082)	1.84316156
96	Polydipsia (HP:0001959)	1.84316156
97	Sclerocornea (HP:0000647)	1.84193416
98	Failure to thrive in infancy (HP:0001531)	1.83718902
99	Chronic diarrhea (HP:0002028)	1.80976083
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.78592862

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	6.08614256
2	TXK	4.21622244
3	BMPR1B	3.09123964
4	MAPKAPK5	2.42678252
5	CDK8	2.40130614
6	TAOK3	2.32568686
7	TLK1	2.22870249
8	PKN2	2.12210026
9	VRK1	2.11051217
10	VRK2	2.08746929
11	FLT3	2.04994095
12	BCKDK	2.00190392
13	NUAK1	1.97232574
14	MAP4K1	1.81809383
15	FRK	1.77930041
16	WNK4	1.75146699
17	DAPK2	1.73203854
18	TAF1	1.72907704
19	TGFBR1	1.71829867
20	ADRBK2	1.51543155
21	ZAK	1.50259027
22	ITK	1.43230167
23	TNK2	1.42724875
24	BLK	1.36078900
25	MKNK1	1.33794811
26	EIF2AK3	1.30634685
27	GRK5	1.25217791
28	TEC	1.23121667
29	PRKD3	1.14104140
30	GRK1	1.12269863
31	GRK7	1.05571295
32	MOS	1.02125506
33	MUSK	0.98742217
34	GRK6	0.97285158
35	PIK3CA	0.93169533
36	STK16	0.91778355
37	PLK2	0.91112643
38	KDR	0.90732879
39	RPS6KA5	0.90625804
40	PLK3	0.89415229
41	DAPK1	0.89080380
42	EIF2AK1	0.85615314
43	NEK1	0.85604258
44	MAP3K7	0.84514067
45	PAK6	0.83306441
46	NTRK2	0.83080564
47	PAK3	0.82938486
48	TIE1	0.81871726
49	SYK	0.81371983
50	WNK3	0.78946130
51	RPS6KA4	0.78277331
52	DYRK2	0.77053643
53	INSRR	0.76961567
54	CDK9	0.74699752
55	IKBKE	0.73434981
56	PRKCQ	0.72752248
57	IKBKB	0.68225646
58	MAP3K4	0.67394653
59	MAP2K7	0.64863280
60	MST4	0.64821162
61	STK39	0.64729544
62	PDK2	0.64080710
63	EIF2AK2	0.62873993
64	STK24	0.62592569
65	RIPK4	0.62551439
66	RPS6KA6	0.60738042
67	CAMKK2	0.59791356
68	STK10	0.58559554
69	OXSR1	0.57325149
70	ADRBK1	0.56885195
71	IRAK4	0.56586196
72	DAPK3	0.54811335
73	DYRK3	0.52413966
74	ZAP70	0.51005930
75	RPS6KA2	0.48274840
76	CDC7	0.47346657
77	BRD4	0.46852806
78	TRIM28	0.46677219
79	CAMK2D	0.46252370
80	MAPK13	0.44389655
81	NME1	0.44268501
82	CASK	0.42817276
83	RPS6KL1	0.41789632
84	RPS6KC1	0.41789632
85	PRKCE	0.41277269
86	LCK	0.41163905
87	PIM1	0.40870771
88	NTRK3	0.39959849
89	ARAF	0.39349897
90	IGF1R	0.36863369
91	LYN	0.36315511
92	BTK	0.35822969
93	CSNK1A1	0.35503511
94	TNIK	0.35472962
95	PIK3CG	0.34018635
96	CSNK1G3	0.33171273
97	CDK19	0.31809535
98	JAK2	0.31208987
99	KIT	0.31137557
100	FGFR1	0.30283273

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary immunodeficiency_Homo sapiens_hsa05340	3.75904289
2	Proteasome_Homo sapiens_hsa03050	3.73731854
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.08778922
4	Parkinsons disease_Homo sapiens_hsa05012	2.91977890
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.70800938
6	Basal transcription factors_Homo sapiens_hsa03022	2.62780902
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.47776145
8	Protein export_Homo sapiens_hsa03060	2.36379491
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.17388593
10	Ribosome_Homo sapiens_hsa03010	2.12546420
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.01077895
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.92339691
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.86339655
14	Phototransduction_Homo sapiens_hsa04744	1.84743105
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.79497080
16	Allograft rejection_Homo sapiens_hsa05330	1.73471668
17	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.69389017
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.67032277
19	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.66274403
20	Graft-versus-host disease_Homo sapiens_hsa05332	1.65407712
21	Huntingtons disease_Homo sapiens_hsa05016	1.64136014
22	RNA polymerase_Homo sapiens_hsa03020	1.63478916
23	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.60202329
24	Alzheimers disease_Homo sapiens_hsa05010	1.56154905
25	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.54465108
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.52612388
27	Homologous recombination_Homo sapiens_hsa03440	1.50760972
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49487694
29	Propanoate metabolism_Homo sapiens_hsa00640	1.47982362
30	Butanoate metabolism_Homo sapiens_hsa00650	1.44711963
31	RNA degradation_Homo sapiens_hsa03018	1.39907659
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.39011251
33	Asthma_Homo sapiens_hsa05310	1.35913956
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.34230857
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.27672608
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.26555673
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.20672315
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.19124379
39	Peroxisome_Homo sapiens_hsa04146	1.16976863
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14719176
41	Rheumatoid arthritis_Homo sapiens_hsa05323	1.02906437
42	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.00156703
43	Purine metabolism_Homo sapiens_hsa00230	0.97536684
44	Ether lipid metabolism_Homo sapiens_hsa00565	0.94471621
45	Caffeine metabolism_Homo sapiens_hsa00232	0.93067084
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.92875322
47	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.90321017
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.87444517
49	Salivary secretion_Homo sapiens_hsa04970	0.86926964
50	Taste transduction_Homo sapiens_hsa04742	0.83522758
51	Fanconi anemia pathway_Homo sapiens_hsa03460	0.81347799
52	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.77647439
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.76829638
54	Retinol metabolism_Homo sapiens_hsa00830	0.75694127
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.75144540
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72808254
57	Mismatch repair_Homo sapiens_hsa03430	0.71057472
58	Pyruvate metabolism_Homo sapiens_hsa00620	0.68668209
59	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.67053077
60	Spliceosome_Homo sapiens_hsa03040	0.64689155
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63484685
62	One carbon pool by folate_Homo sapiens_hsa00670	0.62871894
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.60200211
64	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60121356
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59808505
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58732413
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.58546380
68	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.58057003
69	Tryptophan metabolism_Homo sapiens_hsa00380	0.57896250
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.56669536
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56269699
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55295518
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54882466
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53320567
75	Olfactory transduction_Homo sapiens_hsa04740	0.52680659
76	Metabolic pathways_Homo sapiens_hsa01100	0.52588439
77	Regulation of autophagy_Homo sapiens_hsa04140	0.51849303
78	DNA replication_Homo sapiens_hsa03030	0.51771816
79	Measles_Homo sapiens_hsa05162	0.51320066
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47552022
81	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47269201
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.46121818
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45661104
84	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.45523342
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40887344
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38939440
87	RNA transport_Homo sapiens_hsa03013	0.37767727
88	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.34291266
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.32059905
90	Serotonergic synapse_Homo sapiens_hsa04726	0.30842384
91	Renin secretion_Homo sapiens_hsa04924	0.29290481
92	Glycerolipid metabolism_Homo sapiens_hsa00561	0.28049862
93	Circadian entrainment_Homo sapiens_hsa04713	0.26014991
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.24871283
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.23918456
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.22711792
97	Fatty acid elongation_Homo sapiens_hsa00062	0.22005724
98	Malaria_Homo sapiens_hsa05144	0.21377375
99	Insulin secretion_Homo sapiens_hsa04911	0.20903405
100	Nicotine addiction_Homo sapiens_hsa05033	0.20803866

ST13P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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