ST13P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sarcomere organization (GO:0060297)5.91194168
2behavioral response to nicotine (GO:0035095)5.69322690
3regulation of action potential (GO:0098900)4.87216627
4organelle disassembly (GO:1903008)4.82114655
5regulation of skeletal muscle contraction (GO:0014819)4.80101309
6negative regulation of organelle assembly (GO:1902116)4.77180018
7DNA deamination (GO:0045006)4.75261453
8protein polyglutamylation (GO:0018095)4.58970823
9ribonucleoprotein complex disassembly (GO:0032988)4.36005241
10chaperone-mediated protein transport (GO:0072321)4.30938663
11L-fucose metabolic process (GO:0042354)4.26223011
12L-fucose catabolic process (GO:0042355)4.26223011
13fucose catabolic process (GO:0019317)4.26223011
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.02437029
15NADH dehydrogenase complex assembly (GO:0010257)4.02437029
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.02437029
17plasma membrane repair (GO:0001778)3.99718126
18negative regulation of nitric-oxide synthase activity (GO:0051001)3.97951238
19negative regulation of muscle hypertrophy (GO:0014741)3.94525342
20ATP synthesis coupled proton transport (GO:0015986)3.93482684
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.93482684
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.91027186
23negative regulation of protein localization to cell surface (GO:2000009)3.87472656
24translational termination (GO:0006415)3.80113172
25viral transcription (GO:0019083)3.80025622
26ribosomal small subunit assembly (GO:0000028)3.71344681
27water-soluble vitamin biosynthetic process (GO:0042364)3.70795007
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69062658
29translational elongation (GO:0006414)3.68085019
30protein neddylation (GO:0045116)3.61900916
31maturation of SSU-rRNA (GO:0030490)3.61076766
32preassembly of GPI anchor in ER membrane (GO:0016254)3.50416908
33negative regulation of reactive oxygen species metabolic process (GO:2000378)3.43685695
34protein complex biogenesis (GO:0070271)3.43279902
35postreplication repair (GO:0006301)3.40485141
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39377851
37negative regulation of potassium ion transmembrane transport (GO:1901380)3.37201792
38somite development (GO:0061053)3.33254477
39negative regulation of transcription regulatory region DNA binding (GO:2000678)3.31039807
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28833350
41negative regulation of cardiac muscle tissue growth (GO:0055022)3.27016937
42negative regulation of heart growth (GO:0061117)3.27016937
43cotranslational protein targeting to membrane (GO:0006613)3.25847831
44protein targeting to ER (GO:0045047)3.25098134
45iron-sulfur cluster assembly (GO:0016226)3.24929412
46metallo-sulfur cluster assembly (GO:0031163)3.24929412
47pseudouridine synthesis (GO:0001522)3.22653479
48mitochondrial respiratory chain complex assembly (GO:0033108)3.16727247
49establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11899133
50ribosomal large subunit biogenesis (GO:0042273)3.06468877
51protein localization to endoplasmic reticulum (GO:0070972)3.04056338
52transmission of nerve impulse (GO:0019226)3.04037824
53ribosomal small subunit biogenesis (GO:0042274)2.99660237
54activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.98890447
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.98786562
56cellular protein complex disassembly (GO:0043624)2.87177295
57electron transport chain (GO:0022900)2.84374826
58synaptic transmission, cholinergic (GO:0007271)2.83552547
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83392497
60GTP biosynthetic process (GO:0006183)2.82311634
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.82098012
62respiratory electron transport chain (GO:0022904)2.78743533
63platelet dense granule organization (GO:0060155)2.77925101
64viral life cycle (GO:0019058)2.76883643
65axoneme assembly (GO:0035082)2.75930254
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74072767
67rRNA modification (GO:0000154)2.72538125
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71805144
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71805144
70tongue development (GO:0043586)2.70609313
71cellular ketone body metabolic process (GO:0046950)2.66623013
72negative regulation of heart rate (GO:0010459)2.66521780
73striated muscle atrophy (GO:0014891)2.65971617
74dentate gyrus development (GO:0021542)2.64870667
75protein K6-linked ubiquitination (GO:0085020)2.63308607
76rRNA methylation (GO:0031167)2.62906009
77peptidyl-histidine modification (GO:0018202)2.62571103
78translation (GO:0006412)2.61322003
79myoblast migration (GO:0051451)2.59531875
80establishment of protein localization to mitochondrial membrane (GO:0090151)2.58253647
81termination of RNA polymerase III transcription (GO:0006386)2.57546199
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.57546199
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57515627
84C-terminal protein lipidation (GO:0006501)2.57429722
85positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.57344792
86regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53518128
87skeletal muscle tissue regeneration (GO:0043403)2.51909499
88macromolecular complex disassembly (GO:0032984)2.51752071
89positive regulation of protein homodimerization activity (GO:0090073)2.51733596
90positive regulation of meiosis (GO:0045836)2.51186075
91ncRNA 3-end processing (GO:0043628)2.50669425
92nonmotile primary cilium assembly (GO:0035058)2.50007933
93kynurenine metabolic process (GO:0070189)2.49326550
94retinal cone cell development (GO:0046549)2.47536179
95translational initiation (GO:0006413)2.47462855
96positive regulation of microtubule polymerization (GO:0031116)2.46001042
97maturation of 5.8S rRNA (GO:0000460)2.45485207
98mannosylation (GO:0097502)2.45282776
99cell proliferation in forebrain (GO:0021846)2.43436805
100negative regulation of mast cell activation (GO:0033004)2.43293181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.55061492
2ZNF274_21170338_ChIP-Seq_K562_Hela4.19285591
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.61068114
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.36863954
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.36769077
6EZH2_22144423_ChIP-Seq_EOC_Human2.99280125
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95405573
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.75865435
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.70754998
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35546535
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31171363
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.28606959
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.22958617
14IGF1R_20145208_ChIP-Seq_DFB_Human2.17679967
15IRF1_19129219_ChIP-ChIP_H3396_Human2.16504180
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.15762467
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04811253
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.95816186
19SRF_21415370_ChIP-Seq_HL-1_Mouse1.92531380
20MYC_18940864_ChIP-ChIP_HL60_Human1.92416663
21FUS_26573619_Chip-Seq_HEK293_Human1.84270018
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83689565
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65052823
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64401574
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.63640362
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62622363
27GBX2_23144817_ChIP-Seq_PC3_Human1.62250242
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60816799
29ELK1_19687146_ChIP-ChIP_HELA_Human1.60184472
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60008050
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.59588728
32VDR_23849224_ChIP-Seq_CD4+_Human1.59524708
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57833914
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55397630
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52969171
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51077259
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49896486
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.48056991
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44124801
40EWS_26573619_Chip-Seq_HEK293_Human1.43618485
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43307369
42TP53_22573176_ChIP-Seq_HFKS_Human1.43265624
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37191826
44GABP_19822575_ChIP-Seq_HepG2_Human1.33401315
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33380534
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29497784
47TP63_19390658_ChIP-ChIP_HaCaT_Human1.28008876
48CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22894844
49HTT_18923047_ChIP-ChIP_STHdh_Human1.22185762
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.21123502
51TAF2_19829295_ChIP-Seq_ESCs_Human1.20554774
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19901552
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.19847518
54NCOR_22424771_ChIP-Seq_293T_Human1.19234635
55FOXP3_21729870_ChIP-Seq_TREG_Human1.15514479
56TAF15_26573619_Chip-Seq_HEK293_Human1.14129230
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13062863
58TTF2_22483619_ChIP-Seq_HELA_Human1.11788979
59ER_23166858_ChIP-Seq_MCF-7_Human1.10124641
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09537182
61REST_21632747_ChIP-Seq_MESCs_Mouse1.09271769
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.07118616
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06104656
64AR_20517297_ChIP-Seq_VCAP_Human1.05699773
65P300_19829295_ChIP-Seq_ESCs_Human1.04965590
66MYC_19829295_ChIP-Seq_ESCs_Human1.04230368
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01310489
68SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99699805
69AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99143767
70GATA3_21878914_ChIP-Seq_MCF-7_Human0.99056672
71ERA_21632823_ChIP-Seq_H3396_Human0.98640669
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97936774
73STAT3_23295773_ChIP-Seq_U87_Human0.97858696
74POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97545049
75THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96376005
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96265782
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95569472
78RNF2_27304074_Chip-Seq_NSC_Mouse0.94489284
79P53_21459846_ChIP-Seq_SAOS-2_Human0.93312572
80CBP_20019798_ChIP-Seq_JUKART_Human0.92935460
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92935460
82FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92853653
83FOXA1_25329375_ChIP-Seq_VCAP_Human0.92853653
84YY1_21170310_ChIP-Seq_MESCs_Mouse0.92180405
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91784366
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90799000
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90182390
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88799407
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.88115083
90REST_18959480_ChIP-ChIP_MESCs_Mouse0.86899547
91TAL1_26923725_Chip-Seq_HPCs_Mouse0.86663596
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86210774
93NANOG_20526341_ChIP-Seq_ESCs_Human0.85771292
94SOX2_19829295_ChIP-Seq_ESCs_Human0.85632039
95NANOG_19829295_ChIP-Seq_ESCs_Human0.85632039
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85509082
97JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85259897
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84871062
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84654124
100EED_16625203_ChIP-ChIP_MESCs_Mouse0.84372238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.75747036
2MP0000372_irregular_coat_pigmentation3.61766292
3MP0003950_abnormal_plasma_membrane3.23936033
4MP0002102_abnormal_ear_morphology3.20382131
5MP0002837_dystrophic_cardiac_calcinosis2.65126996
6MP0003787_abnormal_imprinting2.62668463
7MP0009379_abnormal_foot_pigmentation2.59485410
8MP0001293_anophthalmia2.32415889
9MP0006072_abnormal_retinal_apoptosis2.22026747
10MP0004145_abnormal_muscle_electrophysio2.16780381
11MP0009046_muscle_twitch2.08554708
12MP0001485_abnormal_pinna_reflex2.07695023
13MP0008789_abnormal_olfactory_epithelium1.99696434
14MP0002163_abnormal_gland_morphology1.99284497
15MP0003136_yellow_coat_color1.95345595
16MP0003693_abnormal_embryo_hatching1.95073357
17MP0006276_abnormal_autonomic_nervous1.94729985
18MP0002638_abnormal_pupillary_reflex1.86905860
19MP0004270_analgesia1.84000996
20MP0008877_abnormal_DNA_methylation1.76010864
21MP0004142_abnormal_muscle_tone1.74739209
22MP0002234_abnormal_pharynx_morphology1.70298077
23MP0002733_abnormal_thermal_nociception1.67183988
24MP0000749_muscle_degeneration1.64937659
25MP0002938_white_spotting1.61586579
26MP0005499_abnormal_olfactory_system1.56352166
27MP0005394_taste/olfaction_phenotype1.56352166
28MP0005379_endocrine/exocrine_gland_phen1.54254972
29MP0000566_synostosis1.51010467
30MP0003122_maternal_imprinting1.46197654
31MP0005084_abnormal_gallbladder_morpholo1.44660874
32MP0002095_abnormal_skin_pigmentation1.43732205
33MP0005645_abnormal_hypothalamus_physiol1.42311473
34MP0000569_abnormal_digit_pigmentation1.42027156
35MP0000049_abnormal_middle_ear1.39100264
36MP0005551_abnormal_eye_electrophysiolog1.38204597
37MP0000778_abnormal_nervous_system1.37265158
38MP0002138_abnormal_hepatobiliary_system1.36388266
39MP0003646_muscle_fatigue1.34345263
40MP0001529_abnormal_vocalization1.34257835
41MP0005187_abnormal_penis_morphology1.32812526
42MP0001968_abnormal_touch/_nociception1.30682247
43MP0010030_abnormal_orbit_morphology1.30533210
44MP0009053_abnormal_anal_canal1.28386278
45MP0008872_abnormal_physiological_respon1.26413887
46MP0008775_abnormal_heart_ventricle1.25638928
47MP0009745_abnormal_behavioral_response1.23774360
48MP0001486_abnormal_startle_reflex1.20999850
49MP0008875_abnormal_xenobiotic_pharmacok1.18799749
50MP0003121_genomic_imprinting1.18546485
51MP0005195_abnormal_posterior_eye1.18362688
52MP0001905_abnormal_dopamine_level1.17405402
53MP0001919_abnormal_reproductive_system1.16951593
54MP0004885_abnormal_endolymph1.14936081
55MP0001970_abnormal_pain_threshold1.12578081
56MP0005423_abnormal_somatic_nervous1.10644607
57MP0002734_abnormal_mechanical_nocicepti1.08725655
58MP0004742_abnormal_vestibular_system1.02835304
59MP0003283_abnormal_digestive_organ1.01441619
60MP0003890_abnormal_embryonic-extraembry1.00333692
61MP0002272_abnormal_nervous_system1.00179501
62MP0002572_abnormal_emotion/affect_behav0.99951723
63MP0002736_abnormal_nociception_after0.99733728
64MP0002752_abnormal_somatic_nervous0.99036618
65MP0004147_increased_porphyrin_level0.98880487
66MP0005389_reproductive_system_phenotype0.98455520
67MP0002653_abnormal_ependyma_morphology0.98269546
68MP0000427_abnormal_hair_cycle0.98207983
69MP0002184_abnormal_innervation0.98139771
70MP0002067_abnormal_sensory_capabilities0.97475332
71MP0004215_abnormal_myocardial_fiber0.96604973
72MP0003567_abnormal_fetal_cardiomyocyte0.95758260
73MP0005253_abnormal_eye_physiology0.95697836
74MP0002557_abnormal_social/conspecific_i0.95594381
75MP0000631_abnormal_neuroendocrine_gland0.94815492
76MP0003186_abnormal_redox_activity0.92171245
77MP0005391_vision/eye_phenotype0.92170782
78MP0003195_calcinosis0.91575753
79MP0000647_abnormal_sebaceous_gland0.90937079
80MP0003938_abnormal_ear_development0.89642125
81MP0008058_abnormal_DNA_repair0.89616466
82MP0004924_abnormal_behavior0.88354833
83MP0005386_behavior/neurological_phenoty0.88354833
84MP0002928_abnormal_bile_duct0.87859989
85MP0001986_abnormal_taste_sensitivity0.87643803
86MP0008995_early_reproductive_senescence0.85135284
87MP0002751_abnormal_autonomic_nervous0.84448428
88MP0000026_abnormal_inner_ear0.84089348
89MP0000751_myopathy0.83184929
90MP0003718_maternal_effect0.82340884
91MP0002160_abnormal_reproductive_system0.82097296
92MP0000230_abnormal_systemic_arterial0.81811204
93MP0004133_heterotaxia0.80048053
94MP0002735_abnormal_chemical_nociception0.79520836
95MP0002063_abnormal_learning/memory/cond0.76484962
96MP0003878_abnormal_ear_physiology0.76048576
97MP0005377_hearing/vestibular/ear_phenot0.76048576
98MP0005620_abnormal_muscle_contractility0.75943980
99MP0001984_abnormal_olfaction0.74939261
100MP0003936_abnormal_reproductive_system0.72298050

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.13341326
2Acute encephalopathy (HP:0006846)4.00833304
3Molar tooth sign on MRI (HP:0002419)3.73441027
4Abnormality of midbrain morphology (HP:0002418)3.73441027
5Calf muscle hypertrophy (HP:0008981)3.69506956
6Congenital stationary night blindness (HP:0007642)3.47646854
7Progressive macrocephaly (HP:0004481)3.45681645
8Abnormal mitochondria in muscle tissue (HP:0008316)3.40852208
9Muscle hypertrophy of the lower extremities (HP:0008968)3.31997294
10Palpebral edema (HP:0100540)3.30411409
113-Methylglutaconic aciduria (HP:0003535)3.22515644
12Type 2 muscle fiber atrophy (HP:0003554)3.13701729
13Abnormality of alanine metabolism (HP:0010916)3.13229885
14Hyperalaninemia (HP:0003348)3.13229885
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.13229885
16Nephronophthisis (HP:0000090)3.11538347
17Subaortic stenosis (HP:0001682)3.10146937
18Abnormality of the left ventricular outflow tract (HP:0011103)3.10146937
19Renal cortical cysts (HP:0000803)3.08989812
20Pancreatic fibrosis (HP:0100732)3.07696002
21Abnormality of the renal cortex (HP:0011035)2.95739475
22Pancreatic cysts (HP:0001737)2.94985026
23Exercise-induced muscle cramps (HP:0003710)2.94446679
24Mitochondrial inheritance (HP:0001427)2.92270054
25Agitation (HP:0000713)2.91495106
26Increased CSF lactate (HP:0002490)2.90553975
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.89915692
28Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.89915692
29Myotonia (HP:0002486)2.88224462
30Hyperglycinemia (HP:0002154)2.87484419
31Reticulocytopenia (HP:0001896)2.72483555
32Colon cancer (HP:0003003)2.71347929
33True hermaphroditism (HP:0010459)2.70960560
34Muscle fiber atrophy (HP:0100295)2.69427096
35Cerebral edema (HP:0002181)2.67963291
36Abnormality of the renal medulla (HP:0100957)2.60678627
37Abnormality of the labia minora (HP:0012880)2.60596124
38Congenital, generalized hypertrichosis (HP:0004540)2.56588391
39Abnormality of the corticospinal tract (HP:0002492)2.54956133
40Microvesicular hepatic steatosis (HP:0001414)2.51563806
41Methylmalonic acidemia (HP:0002912)2.50744763
42Exercise-induced myalgia (HP:0003738)2.49518345
43Pendular nystagmus (HP:0012043)2.44225731
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43699295
45Concave nail (HP:0001598)2.41111847
46Optic disc pallor (HP:0000543)2.40317674
47Medial flaring of the eyebrow (HP:0010747)2.39746542
48Severe muscular hypotonia (HP:0006829)2.31818381
49Type II lissencephaly (HP:0007260)2.31729797
50Attenuation of retinal blood vessels (HP:0007843)2.31297898
51Increased serum pyruvate (HP:0003542)2.31175557
52Abnormal rod and cone electroretinograms (HP:0008323)2.31138945
53Prolonged QT interval (HP:0001657)2.30916154
54Keratoconus (HP:0000563)2.29201950
55Increased corneal curvature (HP:0100692)2.29201950
56Abolished electroretinogram (ERG) (HP:0000550)2.27366075
57Supernumerary spleens (HP:0009799)2.27333754
58Increased serum lactate (HP:0002151)2.27013521
59Cerebellar dysplasia (HP:0007033)2.21303784
60Brushfield spots (HP:0001088)2.20613773
61Pachygyria (HP:0001302)2.17289332
62Recurrent corneal erosions (HP:0000495)2.13878419
63Anencephaly (HP:0002323)2.13532360
64Sclerocornea (HP:0000647)2.13368009
65Constricted visual fields (HP:0001133)2.11475077
66Occipital encephalocele (HP:0002085)2.08689449
67Abnormality of cells of the erythroid lineage (HP:0012130)2.08278715
68Genetic anticipation (HP:0003743)2.05271453
69Lethargy (HP:0001254)2.04412559
70Lissencephaly (HP:0001339)2.04409130
71Methylmalonic aciduria (HP:0012120)2.03373797
72Increased hepatocellular lipid droplets (HP:0006565)2.01816299
73Lactic acidosis (HP:0003128)2.01206051
74Poor suck (HP:0002033)2.01030689
75Abnormality of glycolysis (HP:0004366)1.99504144
76Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97491002
77Hepatocellular necrosis (HP:0001404)1.97312484
78Tubular atrophy (HP:0000092)1.96587381
79Arthropathy (HP:0003040)1.96170255
80Lipid accumulation in hepatocytes (HP:0006561)1.94582762
81Hepatic necrosis (HP:0002605)1.93671816
82Oligodactyly (hands) (HP:0001180)1.93277180
83Fair hair (HP:0002286)1.93009629
84Inability to walk (HP:0002540)1.91641049
85Cystic liver disease (HP:0006706)1.89877802
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.85408421
87Abnormal number of erythroid precursors (HP:0012131)1.85000586
88Macrocytic anemia (HP:0001972)1.81545219
89Oligodactyly (HP:0012165)1.80807831
90Type I transferrin isoform profile (HP:0003642)1.80803925
91Muscle stiffness (HP:0003552)1.80433253
92Gait imbalance (HP:0002141)1.79974826
93Absent phalangeal crease (HP:0006109)1.77286343
94Focal motor seizures (HP:0011153)1.75465642
95Nephrogenic diabetes insipidus (HP:0009806)1.74065119
96Furrowed tongue (HP:0000221)1.73373729
97Hypoplasia of the thymus (HP:0000778)1.73100118
98Congenital primary aphakia (HP:0007707)1.72909992
99Leukodystrophy (HP:0002415)1.72009102
100Restlessness (HP:0000711)1.71790836

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK53.72790403
2MAP4K23.32093588
3ZAK3.31329941
4INSRR3.09915660
5WNK42.76637667
6STK162.71822473
7PINK12.63987202
8ADRBK22.44185062
9NUAK12.32220408
10CDK82.23580813
11MAP3K112.15729699
12EPHB22.09327886
13FRK1.97381873
14VRK21.92068160
15BCKDK1.87356142
16TAF11.79155187
17PIK3CA1.76211505
18STK391.72435127
19CCNB11.71012232
20MUSK1.70735418
21CAMKK21.68106570
22DYRK21.53829844
23VRK11.52856387
24BMPR1B1.47064288
25GRK11.39678118
26CSNK1G31.37248846
27PDK21.30991325
28CSNK1G21.29420120
29TLK11.28021989
30NTRK11.24049145
31WNK31.21380705
32CSNK1A1L1.16360855
33MKNK11.14859013
34CSNK1G11.10691531
35TAOK31.08975587
36MST41.05325588
37PHKG11.04037195
38PHKG21.04037195
39OXSR11.03675444
40AURKA1.03619154
41CDK191.00855003
42CASK0.99654002
43LIMK10.97122645
44MOS0.93709766
45CDK90.89504556
46PRKCG0.89178841
47NTRK20.88536912
48CHEK20.87910525
49MARK10.87001512
50PLK10.84772483
51RPS6KA50.82691094
52TYRO30.81207050
53CAMK2D0.79983674
54MAPKAPK30.79818731
55TIE10.79814355
56DMPK0.79577796
57NME20.78404817
58PAK60.78371072
59PRKCQ0.78304926
60MAP2K70.74459321
61MAPK130.74307455
62GRK50.72282403
63ADRBK10.70662326
64NEK20.69656352
65GRK70.68535333
66MATK0.64390877
67TGFBR10.63325976
68OBSCN0.62520569
69PLK30.61850621
70ICK0.60545760
71MAP3K40.59801791
72BUB10.57276100
73PLK20.56518063
74CAMK1D0.55630239
75EIF2AK10.54207720
76SRPK10.53754876
77TNK20.51793267
78PRKCZ0.50960468
79PRKCE0.50773499
80CAMK2A0.50178283
81FES0.48803814
82TEC0.46477534
83ATR0.45143125
84PRKACB0.44882764
85MKNK20.44661789
86CAMK10.44254269
87AURKB0.43827723
88ITK0.42429654
89STK110.40908952
90TSSK60.40733593
91UHMK10.38849926
92CSNK1E0.37704906
93TNIK0.36993590
94EIF2AK30.35979712
95PRKACA0.35382960
96NLK0.34496393
97CDC70.34038410
98CSNK2A10.32168631
99CAMK2G0.30942506
100CAMK2B0.29650212

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.76619090
2Oxidative phosphorylation_Homo sapiens_hsa001903.46534699
3Parkinsons disease_Homo sapiens_hsa050123.08879859
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.64347120
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54281268
6Butanoate metabolism_Homo sapiens_hsa006502.50128112
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.47929974
8RNA polymerase_Homo sapiens_hsa030202.34169544
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25275005
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23290986
11Cardiac muscle contraction_Homo sapiens_hsa042602.12781784
12Proteasome_Homo sapiens_hsa030502.11360097
13Propanoate metabolism_Homo sapiens_hsa006402.02219962
14Huntingtons disease_Homo sapiens_hsa050162.02180712
15Alzheimers disease_Homo sapiens_hsa050101.97657381
16Protein export_Homo sapiens_hsa030601.95884261
17Homologous recombination_Homo sapiens_hsa034401.75353242
18Linoleic acid metabolism_Homo sapiens_hsa005911.71478743
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71319913
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70099753
21Selenocompound metabolism_Homo sapiens_hsa004501.69476152
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68277023
23Tryptophan metabolism_Homo sapiens_hsa003801.60114638
24Sulfur relay system_Homo sapiens_hsa041221.55817177
25One carbon pool by folate_Homo sapiens_hsa006701.50501640
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49093189
27RNA degradation_Homo sapiens_hsa030181.44380495
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42386815
29Phototransduction_Homo sapiens_hsa047441.40260202
30Caffeine metabolism_Homo sapiens_hsa002321.36915692
31Pyruvate metabolism_Homo sapiens_hsa006201.36327447
32Peroxisome_Homo sapiens_hsa041461.36157330
33beta-Alanine metabolism_Homo sapiens_hsa004101.32919303
34Basal transcription factors_Homo sapiens_hsa030221.31472696
35Fanconi anemia pathway_Homo sapiens_hsa034601.27814459
36Folate biosynthesis_Homo sapiens_hsa007901.27501136
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22805736
38Nitrogen metabolism_Homo sapiens_hsa009101.21336040
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16412858
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10574368
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.08931864
42Mismatch repair_Homo sapiens_hsa034301.07393174
43Ether lipid metabolism_Homo sapiens_hsa005651.05656026
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03594281
45Pyrimidine metabolism_Homo sapiens_hsa002401.03567305
46Purine metabolism_Homo sapiens_hsa002300.95143166
47Sulfur metabolism_Homo sapiens_hsa009200.88511080
48Base excision repair_Homo sapiens_hsa034100.86243793
49Nucleotide excision repair_Homo sapiens_hsa034200.85864859
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78886282
51Metabolic pathways_Homo sapiens_hsa011000.77803946
52Systemic lupus erythematosus_Homo sapiens_hsa053220.76782885
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75846176
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.75788866
55Fatty acid degradation_Homo sapiens_hsa000710.75514414
56Fat digestion and absorption_Homo sapiens_hsa049750.72745746
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72387546
58Spliceosome_Homo sapiens_hsa030400.71946398
59RNA transport_Homo sapiens_hsa030130.71096878
60Arginine and proline metabolism_Homo sapiens_hsa003300.70767231
61Regulation of autophagy_Homo sapiens_hsa041400.70281156
62Glycerolipid metabolism_Homo sapiens_hsa005610.67950243
63Chemical carcinogenesis_Homo sapiens_hsa052040.66796307
64Nicotine addiction_Homo sapiens_hsa050330.66399668
65Histidine metabolism_Homo sapiens_hsa003400.65295596
66Morphine addiction_Homo sapiens_hsa050320.64494400
67Olfactory transduction_Homo sapiens_hsa047400.62868872
68Arachidonic acid metabolism_Homo sapiens_hsa005900.62447394
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.60503694
70Glutathione metabolism_Homo sapiens_hsa004800.58356640
71Alcoholism_Homo sapiens_hsa050340.57733384
72Vitamin B6 metabolism_Homo sapiens_hsa007500.57526483
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53499742
74Fatty acid elongation_Homo sapiens_hsa000620.53391956
75Steroid biosynthesis_Homo sapiens_hsa001000.52462001
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52020799
77p53 signaling pathway_Homo sapiens_hsa041150.51671570
78Serotonergic synapse_Homo sapiens_hsa047260.51396695
79Insulin secretion_Homo sapiens_hsa049110.50408736
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50149617
81Circadian entrainment_Homo sapiens_hsa047130.49563457
82Taste transduction_Homo sapiens_hsa047420.48923272
83ABC transporters_Homo sapiens_hsa020100.48815739
84Cocaine addiction_Homo sapiens_hsa050300.48075616
85Retinol metabolism_Homo sapiens_hsa008300.45586281
86Basal cell carcinoma_Homo sapiens_hsa052170.45251999
87Collecting duct acid secretion_Homo sapiens_hsa049660.45050983
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43855590
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.43216441
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.42605097
91DNA replication_Homo sapiens_hsa030300.42381034
92Ovarian steroidogenesis_Homo sapiens_hsa049130.40484261
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40080950
94Salivary secretion_Homo sapiens_hsa049700.39023415
95Hedgehog signaling pathway_Homo sapiens_hsa043400.34458728
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.30618294
97Carbon metabolism_Homo sapiens_hsa012000.29617334
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.28724143
99Glutamatergic synapse_Homo sapiens_hsa047240.27412597
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24499569

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