ST13P19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.18957848
2cytidine deamination (GO:0009972)6.72826383
3cytidine metabolic process (GO:0046087)6.72826383
4cytidine catabolic process (GO:0006216)6.72826383
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.70564140
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.87114165
7immunoglobulin mediated immune response (GO:0016064)4.43544315
8T cell migration (GO:0072678)4.35280634
9positive regulation of B cell differentiation (GO:0045579)4.17887481
10negative T cell selection (GO:0043383)4.15954674
11positive regulation of alpha-beta T cell proliferation (GO:0046641)4.14300086
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.94987300
13positive regulation of T cell mediated cytotoxicity (GO:0001916)3.93167041
14regulation of B cell receptor signaling pathway (GO:0050855)3.86695343
15B cell mediated immunity (GO:0019724)3.75474012
16response to interferon-beta (GO:0035456)3.69878672
17negative regulation of B cell proliferation (GO:0030889)3.65924564
18negative thymic T cell selection (GO:0045060)3.62286591
19positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.57916187
20regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.56738318
21regulation of sarcomere organization (GO:0060297)3.55537091
22positive regulation of cell killing (GO:0031343)3.52739548
23cellular response to interferon-beta (GO:0035458)3.47444689
24cellular response to interleukin-15 (GO:0071350)3.47115133
25negative regulation of nitric-oxide synthase activity (GO:0051001)3.43816599
26negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.42357663
27ribonucleoprotein complex disassembly (GO:0032988)3.38506531
28DNA demethylation (GO:0080111)3.38443856
29innate immune response in mucosa (GO:0002227)3.38110105
30positive regulation of gamma-delta T cell activation (GO:0046645)3.37632019
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.37231051
32Arp2/3 complex-mediated actin nucleation (GO:0034314)3.37124948
33positive regulation of defense response to virus by host (GO:0002230)3.35221857
34regulation of alpha-beta T cell proliferation (GO:0046640)3.33949095
35negative regulation of viral genome replication (GO:0045071)3.33264083
36regulation of B cell differentiation (GO:0045577)3.33101349
37regulation of T cell mediated cytotoxicity (GO:0001914)3.30699022
38activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.26205607
39regulation of skeletal muscle contraction (GO:0014819)3.24142696
40negative regulation of B cell apoptotic process (GO:0002903)3.23642098
41regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.21776011
42B cell receptor signaling pathway (GO:0050853)3.17197874
43metallo-sulfur cluster assembly (GO:0031163)3.14559919
44iron-sulfur cluster assembly (GO:0016226)3.14559919
45DNA dealkylation (GO:0035510)3.08653117
46regulation of leukocyte mediated cytotoxicity (GO:0001910)3.05625347
47pyrimidine nucleoside catabolic process (GO:0046135)3.04501832
48chaperone mediated protein folding requiring cofactor (GO:0051085)3.02868302
49regulation of cell killing (GO:0031341)3.02865647
50positive regulation of natural killer cell mediated immunity (GO:0002717)3.02709728
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02563863
52antigen processing and presentation of endogenous antigen (GO:0019883)3.02278032
53regulation of isotype switching to IgG isotypes (GO:0048302)3.00256950
54positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99768354
55response to interleukin-15 (GO:0070672)2.98661021
56protein complex biogenesis (GO:0070271)2.97702351
57antigen receptor-mediated signaling pathway (GO:0050851)2.93089930
58negative regulation by host of viral transcription (GO:0043922)2.92734668
59positive thymic T cell selection (GO:0045059)2.91561058
60positive T cell selection (GO:0043368)2.91540614
61negative regulation of T cell apoptotic process (GO:0070233)2.91418087
62regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90626819
63regulation of natural killer cell mediated immunity (GO:0002715)2.90626819
64T cell costimulation (GO:0031295)2.90623816
65positive regulation of humoral immune response (GO:0002922)2.89436962
66negative regulation of lymphocyte apoptotic process (GO:0070229)2.88148756
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87042459
68lymphocyte costimulation (GO:0031294)2.86748659
69actin nucleation (GO:0045010)2.84616820
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84518298
71T cell receptor signaling pathway (GO:0050852)2.83399351
72negative regulation of potassium ion transmembrane transport (GO:1901380)2.83308013
73mucosal immune response (GO:0002385)2.83022754
74regulation of cellular amino acid metabolic process (GO:0006521)2.82866709
75B cell homeostasis (GO:0001782)2.80516406
76membrane raft organization (GO:0031579)2.77333572
77signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73622070
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73622070
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73622070
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73472953
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73472953
82negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.73373598
83positive regulation of calcium-mediated signaling (GO:0050850)2.73014395
84regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70676100
85pyrimidine ribonucleoside metabolic process (GO:0046131)2.68419791
86antibacterial humoral response (GO:0019731)2.67534678
87antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.66850250
88regulation of T cell receptor signaling pathway (GO:0050856)2.65114702
89mast cell activation (GO:0045576)2.64891427
90positive regulation of prostaglandin secretion (GO:0032308)2.64830569
91mitochondrial respiratory chain complex assembly (GO:0033108)2.63384126
92T-helper 1 type immune response (GO:0042088)2.63104449
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62086456
94antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.61855055
95negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.61364981
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61268859
97regulation of B cell apoptotic process (GO:0002902)2.59315565
98mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.59089107
99organ or tissue specific immune response (GO:0002251)2.58644518
100positive regulation of T cell mediated immunity (GO:0002711)2.58090464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.83407120
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.68020492
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.54314745
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.97809310
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.59177097
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.58295383
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.48577441
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22402024
9GATA1_22025678_ChIP-Seq_K562_Human3.03952868
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.72153737
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.71879123
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64121641
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61324540
14EGR1_23403033_ChIP-Seq_LIVER_Mouse2.47441069
15VDR_23849224_ChIP-Seq_CD4+_Human2.45309634
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.42406601
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39043665
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25911821
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.22738958
20VDR_22108803_ChIP-Seq_LS180_Human2.18953163
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.16073956
22NOTCH1_21737748_ChIP-Seq_TLL_Human1.99603974
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.96752517
24MYB_26560356_Chip-Seq_TH2_Human1.95057547
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91652562
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90030304
27CIITA_25753668_ChIP-Seq_RAJI_Human1.88680252
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.86238419
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76194713
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74767828
31HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73347119
32FOXP3_21729870_ChIP-Seq_TREG_Human1.71991306
33ZNF274_21170338_ChIP-Seq_K562_Hela1.67124139
34IRF1_19129219_ChIP-ChIP_H3396_Human1.56400312
35ELK1_19687146_ChIP-ChIP_HELA_Human1.51922685
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51739451
37GATA3_27048872_Chip-Seq_THYMUS_Human1.51473003
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47329760
39MYC_18940864_ChIP-ChIP_HL60_Human1.43923299
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40313354
41MYB_26560356_Chip-Seq_TH1_Human1.39746674
42PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36777076
43MAF_26560356_Chip-Seq_TH1_Human1.35823738
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35288033
45IGF1R_20145208_ChIP-Seq_DFB_Human1.33733457
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32955231
47RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.31925555
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31845418
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31108824
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30808547
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29693468
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29300167
53UTX_26944678_Chip-Seq_JUKART_Human1.27449193
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26429377
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.26056704
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.19630047
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18375285
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16327944
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15733581
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14061354
61GATA3_26560356_Chip-Seq_TH2_Human1.10032833
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.07096156
63BCL6_27268052_Chip-Seq_Bcells_Human1.05700880
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05643857
65NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05274524
66RUNX_20019798_ChIP-Seq_JUKART_Human1.04666780
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04508879
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02518051
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.00243366
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99588462
71SPI1_20517297_ChIP-Seq_HL60_Human0.97263087
72CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97003306
73P300_27268052_Chip-Seq_Bcells_Human0.96412310
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95979617
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95620556
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95436081
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95053293
78MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95024254
79E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94641935
80MAF_26560356_Chip-Seq_TH2_Human0.93924727
81SPI1_23547873_ChIP-Seq_NB4_Human0.93776669
82GABP_19822575_ChIP-Seq_HepG2_Human0.92370510
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91803175
84E2F1_20622854_ChIP-Seq_HELA_Human0.89566899
85BCOR_27268052_Chip-Seq_Bcells_Human0.89427932
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.89257651
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88803023
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88435269
89MYC_22102868_ChIP-Seq_BL_Human0.88320926
90ERG_20517297_ChIP-Seq_VCAP_Human0.87137817
91YY1_22570637_ChIP-Seq_MALME-3M_Human0.86309039
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84113020
93YY1_21170310_ChIP-Seq_MESCs_Mouse0.81660305
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81026593
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.80881124
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80758716
97NANOG_20526341_ChIP-Seq_ESCs_Human0.80512619
98GATA3_21878914_ChIP-Seq_MCF-7_Human0.79638245
99TAF2_19829295_ChIP-Seq_ESCs_Human0.78599730
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77568051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.40029618
2MP0005645_abnormal_hypothalamus_physiol4.82833761
3MP0000685_abnormal_immune_system4.01595195
4MP0001835_abnormal_antigen_presentation3.75251939
5MP0003763_abnormal_thymus_physiology3.22788529
6MP0009785_altered_susceptibility_to3.00891079
7MP0002166_altered_tumor_susceptibility2.92920981
8MP0001800_abnormal_humoral_immune2.83615933
9MP0000372_irregular_coat_pigmentation2.79168774
10MP0001790_abnormal_immune_system2.54408898
11MP0005387_immune_system_phenotype2.54408898
12MP0002102_abnormal_ear_morphology2.50778777
13MP0005000_abnormal_immune_tolerance2.38496424
14MP0002723_abnormal_immune_serum2.30555962
15MP0002148_abnormal_hypersensitivity_rea2.27626603
16MP0002006_tumorigenesis2.22802274
17MP0003950_abnormal_plasma_membrane2.17734680
18MP0002420_abnormal_adaptive_immunity2.10860755
19MP0001819_abnormal_immune_cell2.02980365
20MP0002452_abnormal_antigen_presenting2.02206347
21MP0005025_abnormal_response_to1.96665441
22MP0002398_abnormal_bone_marrow1.87242519
23MP0002837_dystrophic_cardiac_calcinosis1.76110432
24MP0000716_abnormal_immune_system1.75446867
25MP0000689_abnormal_spleen_morphology1.65039951
26MP0005084_abnormal_gallbladder_morpholo1.60565475
27MP0003786_premature_aging1.59070032
28MP0001873_stomach_inflammation1.57232354
29MP0003806_abnormal_nucleotide_metabolis1.56384870
30MP0008058_abnormal_DNA_repair1.55058492
31MP0009333_abnormal_splenocyte_physiolog1.54790544
32MP0009046_muscle_twitch1.44757752
33MP0002429_abnormal_blood_cell1.42546030
34MP0002138_abnormal_hepatobiliary_system1.42464447
35MP0010155_abnormal_intestine_physiology1.41305062
36MP0002722_abnormal_immune_system1.38625330
37MP0000703_abnormal_thymus_morphology1.38560111
38MP0008872_abnormal_physiological_respon1.34937959
39MP0003866_abnormal_defecation1.33281586
40MP0003045_fibrosis1.30653319
41MP0001845_abnormal_inflammatory_respons1.30353273
42MP0002876_abnormal_thyroid_physiology1.28214169
43MP0002405_respiratory_system_inflammati1.28020477
44MP0000749_muscle_degeneration1.26835832
45MP0002736_abnormal_nociception_after1.23969603
46MP0002163_abnormal_gland_morphology1.14826674
47MP0001905_abnormal_dopamine_level1.14246040
48MP0000465_gastrointestinal_hemorrhage1.13571972
49MP0004145_abnormal_muscle_electrophysio1.13566120
50MP0001727_abnormal_embryo_implantation1.11618227
51MP0001853_heart_inflammation1.11123606
52MP0001968_abnormal_touch/_nociception1.10210938
53MP0008469_abnormal_protein_level1.08809983
54MP0005075_abnormal_melanosome_morpholog1.06962689
55MP0003183_abnormal_peptide_metabolism1.06328738
56MP0005464_abnormal_platelet_physiology1.06135793
57MP0002419_abnormal_innate_immunity1.03484167
58MP0001764_abnormal_homeostasis1.00014181
59MP0008789_abnormal_olfactory_epithelium0.99691693
60MP0003436_decreased_susceptibility_to0.94718607
61MP0001919_abnormal_reproductive_system0.92269265
62MP0002019_abnormal_tumor_incidence0.92193821
63MP0006292_abnormal_olfactory_placode0.91741679
64MP0002933_joint_inflammation0.91630587
65MP0006082_CNS_inflammation0.89926721
66MP0010094_abnormal_chromosome_stability0.88082181
67MP0005551_abnormal_eye_electrophysiolog0.84181262
68MP0009643_abnormal_urine_homeostasis0.83119325
69MP0001529_abnormal_vocalization0.82211610
70MP0005166_decreased_susceptibility_to0.81791663
71MP0002693_abnormal_pancreas_physiology0.80789000
72MP0004142_abnormal_muscle_tone0.79550503
73MP0008875_abnormal_xenobiotic_pharmacok0.77943990
74MP0005389_reproductive_system_phenotype0.76540378
75MP0002733_abnormal_thermal_nociception0.75972091
76MP0004084_abnormal_cardiac_muscle0.75938929
77MP0002095_abnormal_skin_pigmentation0.74949034
78MP0005253_abnormal_eye_physiology0.74568158
79MP0005394_taste/olfaction_phenotype0.73244948
80MP0005499_abnormal_olfactory_system0.73244948
81MP0005310_abnormal_salivary_gland0.72538603
82MP0005410_abnormal_fertilization0.72412717
83MP0003252_abnormal_bile_duct0.72031553
84MP0002132_abnormal_respiratory_system0.72020319
85MP0005332_abnormal_amino_acid0.71486035
86MP0002136_abnormal_kidney_physiology0.70909759
87MP0006072_abnormal_retinal_apoptosis0.70026019
88MP0002653_abnormal_ependyma_morphology0.69140625
89MP0005330_cardiomyopathy0.68359944
90MP0002928_abnormal_bile_duct0.67536939
91MP0009697_abnormal_copulation0.66616069
92MP0003724_increased_susceptibility_to0.66585900
93MP0009763_increased_sensitivity_to0.65927617
94MP0003011_delayed_dark_adaptation0.65195982
95MP0008995_early_reproductive_senescence0.62709638
96MP0005379_endocrine/exocrine_gland_phen0.61603565
97MP0006276_abnormal_autonomic_nervous0.60727827
98MP0002083_premature_death0.58637090
99MP0000631_abnormal_neuroendocrine_gland0.56459396
100MP0005377_hearing/vestibular/ear_phenot0.55832922

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)5.00110032
2Aplastic anemia (HP:0001915)4.62145690
3Agammaglobulinemia (HP:0004432)4.48018901
4Hypoplasia of the thymus (HP:0000778)4.21038820
5T lymphocytopenia (HP:0005403)4.10210085
6IgM deficiency (HP:0002850)4.07436343
7Recurrent bronchitis (HP:0002837)4.05937949
8Severe combined immunodeficiency (HP:0004430)3.90808261
9Abnormality of T cells (HP:0002843)3.81947532
10Gastrointestinal stroma tumor (HP:0100723)3.74206248
11Panhypogammaglobulinemia (HP:0003139)3.72437387
12Abnormality of T cell number (HP:0011839)3.71887630
13Chronic diarrhea (HP:0002028)3.70762799
14Elevated erythrocyte sedimentation rate (HP:0003565)3.69647783
15Hypoproteinemia (HP:0003075)3.64004951
16Lymphopenia (HP:0001888)3.58101969
17B lymphocytopenia (HP:0010976)3.52620276
18Recurrent sinusitis (HP:0011108)3.49210512
19Abnormality of B cell number (HP:0010975)3.43490195
20Hepatocellular necrosis (HP:0001404)3.36755977
21IgA deficiency (HP:0002720)3.29810020
22Reduced antithrombin III activity (HP:0001976)3.25798293
23Abnormality of cells of the lymphoid lineage (HP:0012140)3.24310456
24Meningitis (HP:0001287)3.23703423
25Mitochondrial inheritance (HP:0001427)3.21591290
26Calf muscle hypertrophy (HP:0008981)3.19208316
27Abnormality of T cell physiology (HP:0011840)3.14305371
28Thyroiditis (HP:0100646)3.06853009
29Abnormality of the prostate (HP:0008775)3.04211251
30Exercise-induced muscle cramps (HP:0003710)3.03642380
31Hepatic necrosis (HP:0002605)3.00660271
32Dry hair (HP:0011359)2.99217914
33Combined immunodeficiency (HP:0005387)2.97767039
34Abnormal mitochondria in muscle tissue (HP:0008316)2.84259482
35Muscle hypertrophy of the lower extremities (HP:0008968)2.82679520
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.81867253
37Recurrent viral infections (HP:0004429)2.74533645
38Increased CSF lactate (HP:0002490)2.73808075
39Vasculitis (HP:0002633)2.68657099
40Acute necrotizing encephalopathy (HP:0006965)2.68463471
41Bronchitis (HP:0012387)2.67375872
42Prostate neoplasm (HP:0100787)2.66125745
43Increased IgM level (HP:0003496)2.62293802
44Hypoalbuminemia (HP:0003073)2.61125857
45Abnormal albumin level (HP:0012116)2.61125857
46Recurrent fungal infections (HP:0002841)2.57548198
47Autoimmune hemolytic anemia (HP:0001890)2.54447019
48Lymphoma (HP:0002665)2.51621474
49Increased intramyocellular lipid droplets (HP:0012240)2.51249281
50Petechiae (HP:0000967)2.49564845
51Exercise-induced myalgia (HP:0003738)2.48730945
52Abnormal protein glycosylation (HP:0012346)2.43573176
53Abnormal glycosylation (HP:0012345)2.43573176
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.43573176
55Abnormal protein N-linked glycosylation (HP:0012347)2.43573176
56Renal Fanconi syndrome (HP:0001994)2.42998213
57Increased hepatocellular lipid droplets (HP:0006565)2.42353792
58Renal cortical cysts (HP:0000803)2.38256262
59Myotonia (HP:0002486)2.34567495
60Progressive macrocephaly (HP:0004481)2.32034217
61Abnormality of eosinophils (HP:0001879)2.29221928
62Muscle fiber atrophy (HP:0100295)2.28867088
63Eosinophilia (HP:0001880)2.28425677
64Oral leukoplakia (HP:0002745)2.28178748
65Type 2 muscle fiber atrophy (HP:0003554)2.24450390
663-Methylglutaconic aciduria (HP:0003535)2.23766545
67Type I transferrin isoform profile (HP:0003642)2.23447577
68Lipid accumulation in hepatocytes (HP:0006561)2.23331465
69Urticaria (HP:0001025)2.18358599
70Palpebral edema (HP:0100540)2.14734684
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.14663028
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.14663028
73Increased serum lactate (HP:0002151)2.13342328
74Chronic mucocutaneous candidiasis (HP:0002728)2.12559151
75Recurrent cutaneous fungal infections (HP:0011370)2.12559151
76Recurrent pneumonia (HP:0006532)2.11634766
77Stomatitis (HP:0010280)2.11154457
78Mediastinal lymphadenopathy (HP:0100721)2.11125704
79Acute encephalopathy (HP:0006846)2.10106932
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09403526
81Abnormality of macular pigmentation (HP:0008002)2.08047278
82Cerebral edema (HP:0002181)2.07001841
83Increased muscle lipid content (HP:0009058)2.06280058
84Abnormality of macrophages (HP:0004311)2.04582990
85Encephalitis (HP:0002383)2.03952159
86Aplasia/Hypoplasia of the thymus (HP:0010515)2.03226309
87Lactic acidosis (HP:0003128)2.02834616
88Granulocytopenia (HP:0001913)2.01626596
89Abnormality of the left ventricular outflow tract (HP:0011103)2.00149712
90Subaortic stenosis (HP:0001682)2.00149712
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94039533
92Dicarboxylic aciduria (HP:0003215)1.94039533
93Abolished electroretinogram (ERG) (HP:0000550)1.93748690
94Pancytopenia (HP:0001876)1.91107972
95Abnormal rod and cone electroretinograms (HP:0008323)1.89463095
96Exercise intolerance (HP:0003546)1.89429762
97Abnormality of male internal genitalia (HP:0000022)1.88413553
98Skin rash (HP:0000988)1.88407628
99Recurrent lower respiratory tract infections (HP:0002783)1.87470710
100Hepatosplenomegaly (HP:0001433)1.85186206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK14.75462763
2ZAK4.48775510
3TLK14.01014775
4VRK23.81830305
5TXK3.55004714
6MAP4K23.22164807
7BCKDK3.20208040
8MAP4K13.18165887
9KDR2.73748162
10MAPKAPK52.49336816
11TAF12.40759835
12DAPK32.27776877
13NUAK12.04224239
14RPS6KA51.77969088
15TAOK31.65563553
16CCNB11.59846966
17TESK21.59548428
18SYK1.56764182
19DAPK11.53922231
20SMG11.45791164
21MAPKAPK31.37466218
22ITK1.32908002
23AURKA1.30042394
24IRAK41.26416263
25EIF2AK31.23916150
26MUSK1.21981283
27IKBKE1.21652369
28BMPR1B1.20568289
29PRKCQ1.18661527
30ADRBK21.17384106
31MST41.14121532
32PASK1.13416457
33TNK21.12116522
34IKBKB1.11240628
35PIK3CG1.07716155
36KIT0.99585899
37CDK80.98195098
38MATK0.93981348
39FES0.93765952
40BTK0.93611352
41SCYL20.87563483
42PIM10.84834835
43TEC0.83230459
44CSF1R0.82793703
45TBK10.82573343
46LYN0.81564757
47MELK0.77937030
48CDK90.76284651
49DAPK20.74835782
50PIM20.74826112
51GRK10.74010368
52MAP3K110.73992183
53FRK0.73344536
54LCK0.72286645
55INSRR0.70066117
56GRK50.68428033
57NLK0.65416004
58RIPK40.61785244
59BUB10.59650543
60STK40.59549252
61STK160.56076064
62CDK190.53582413
63JAK30.52857799
64CHEK20.51058859
65MAP3K120.50188669
66MAP3K140.49572161
67HIPK20.48139902
68PINK10.44739900
69PRKCD0.43291494
70CSNK1G30.43250716
71EIF2AK20.42217201
72CSK0.39689473
73MAPK70.39492065
74ARAF0.39435593
75CSNK1G20.39170282
76AURKB0.38546505
77FLT30.38382065
78TNIK0.38024918
79TIE10.35951765
80MAPK130.34203976
81PRKD30.33970280
82TESK10.33206563
83DYRK20.31963752
84GRK60.30999177
85WNK30.30958961
86MAP2K70.30551033
87INSR0.30224990
88ATR0.29875032
89ZAP700.29285892
90MAP3K50.29171012
91CDK40.28983577
92OXSR10.28567219
93ABL10.28337513
94MAP3K70.27099270
95PKN10.26979288
96CSNK1G10.24581553
97LIMK10.24132108
98IGF1R0.23751738
99HCK0.23534211
100PRKCA0.21992682

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053225.84202896
2Primary immunodeficiency_Homo sapiens_hsa053404.99017788
3Alcoholism_Homo sapiens_hsa050343.46299351
4Allograft rejection_Homo sapiens_hsa053303.44098933
5Proteasome_Homo sapiens_hsa030503.35309154
6Autoimmune thyroid disease_Homo sapiens_hsa053203.32486598
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.14962190
8Graft-versus-host disease_Homo sapiens_hsa053322.99716385
9Antigen processing and presentation_Homo sapiens_hsa046122.89672144
10Type I diabetes mellitus_Homo sapiens_hsa049402.87227244
11Asthma_Homo sapiens_hsa053102.82397957
12Oxidative phosphorylation_Homo sapiens_hsa001902.09631146
13Viral myocarditis_Homo sapiens_hsa054162.02267845
14Parkinsons disease_Homo sapiens_hsa050121.89885782
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.71523323
16Rheumatoid arthritis_Homo sapiens_hsa053231.49696149
17Hematopoietic cell lineage_Homo sapiens_hsa046401.48523813
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46505081
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40468290
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38174272
21Selenocompound metabolism_Homo sapiens_hsa004501.33693570
22RNA polymerase_Homo sapiens_hsa030201.26206164
23Viral carcinogenesis_Homo sapiens_hsa052031.18864986
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17500054
25Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14870596
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12551223
27Protein export_Homo sapiens_hsa030601.07380002
28DNA replication_Homo sapiens_hsa030301.06156615
29Alzheimers disease_Homo sapiens_hsa050101.04192067
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02891794
31Ribosome_Homo sapiens_hsa030101.02541198
32Base excision repair_Homo sapiens_hsa034100.99425367
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98891451
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97561482
35Homologous recombination_Homo sapiens_hsa034400.95606818
36Huntingtons disease_Homo sapiens_hsa050160.90950783
37Pyrimidine metabolism_Homo sapiens_hsa002400.89710068
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88909127
39Cardiac muscle contraction_Homo sapiens_hsa042600.84743277
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.83654032
41Fatty acid elongation_Homo sapiens_hsa000620.80596044
42Mismatch repair_Homo sapiens_hsa034300.78555352
43Peroxisome_Homo sapiens_hsa041460.76500822
44Staphylococcus aureus infection_Homo sapiens_hsa051500.76103798
45Leishmaniasis_Homo sapiens_hsa051400.75773374
46Herpes simplex infection_Homo sapiens_hsa051680.74475975
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73760303
48Propanoate metabolism_Homo sapiens_hsa006400.72912425
49Spliceosome_Homo sapiens_hsa030400.72349204
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.72293760
51Measles_Homo sapiens_hsa051620.71794580
52T cell receptor signaling pathway_Homo sapiens_hsa046600.70820980
53Butanoate metabolism_Homo sapiens_hsa006500.69098448
54B cell receptor signaling pathway_Homo sapiens_hsa046620.65883915
55Epstein-Barr virus infection_Homo sapiens_hsa051690.65051048
56RNA degradation_Homo sapiens_hsa030180.61127129
57Nucleotide excision repair_Homo sapiens_hsa034200.59331719
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57971904
59Tryptophan metabolism_Homo sapiens_hsa003800.51891638
60One carbon pool by folate_Homo sapiens_hsa006700.50952694
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.50603571
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49114243
63Pyruvate metabolism_Homo sapiens_hsa006200.47121624
64Phototransduction_Homo sapiens_hsa047440.44939338
65Purine metabolism_Homo sapiens_hsa002300.43074295
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.40783911
67Non-homologous end-joining_Homo sapiens_hsa034500.40472572
68Caffeine metabolism_Homo sapiens_hsa002320.40386449
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39656971
70Sulfur metabolism_Homo sapiens_hsa009200.38585321
71Carbon metabolism_Homo sapiens_hsa012000.36240463
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34532964
73Sulfur relay system_Homo sapiens_hsa041220.32972078
74Basal transcription factors_Homo sapiens_hsa030220.31732532
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31341133
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31220242
77Influenza A_Homo sapiens_hsa051640.31174604
78Biosynthesis of amino acids_Homo sapiens_hsa012300.31101328
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.29467735
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29417812
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29141050
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29126477
83Pentose phosphate pathway_Homo sapiens_hsa000300.28567569
84HTLV-I infection_Homo sapiens_hsa051660.27580532
85Linoleic acid metabolism_Homo sapiens_hsa005910.27170781
86Metabolic pathways_Homo sapiens_hsa011000.25696306
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25464063
88N-Glycan biosynthesis_Homo sapiens_hsa005100.24654478
89Shigellosis_Homo sapiens_hsa051310.24434504
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24417060
91Fanconi anemia pathway_Homo sapiens_hsa034600.22430060
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21028132
93Phenylalanine metabolism_Homo sapiens_hsa003600.20294202
94Glutathione metabolism_Homo sapiens_hsa004800.19703648
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18703393
96Phagosome_Homo sapiens_hsa041450.16427253
97Collecting duct acid secretion_Homo sapiens_hsa049660.15778512
98Tuberculosis_Homo sapiens_hsa051520.15400659
99p53 signaling pathway_Homo sapiens_hsa041150.15281250
100beta-Alanine metabolism_Homo sapiens_hsa004100.15150767

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