ST13P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.80925743
2termination of RNA polymerase I transcription (GO:0006363)4.77572338
3peptidyl-histidine modification (GO:0018202)4.66867258
4rRNA methylation (GO:0031167)4.62602398
5regulation of RIG-I signaling pathway (GO:0039535)4.59408119
6rRNA modification (GO:0000154)4.40955648
7cellular response to nicotine (GO:0071316)4.33335925
8transcription initiation from RNA polymerase I promoter (GO:0006361)4.30118049
9transcription elongation from RNA polymerase I promoter (GO:0006362)4.28546801
10regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.26342188
11regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00434.09809284
12preassembly of GPI anchor in ER membrane (GO:0016254)4.06309595
13negative regulation of heart rate (GO:0010459)3.95418153
14synaptic transmission, cholinergic (GO:0007271)3.86482691
15mannosylation (GO:0097502)3.83581588
16transcription from RNA polymerase I promoter (GO:0006360)3.78488408
17positive regulation of hormone biosynthetic process (GO:0046886)3.78268206
18negative regulation of transcription regulatory region DNA binding (GO:2000678)3.76303173
19positive regulation of glycolytic process (GO:0045821)3.65715878
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.65449777
21NADH dehydrogenase complex assembly (GO:0010257)3.65449777
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65449777
23cellular response to interferon-beta (GO:0035458)3.45569735
24protein polyglutamylation (GO:0018095)3.45282895
25positive regulation of heart rate (GO:0010460)3.43123336
26protein localization to cilium (GO:0061512)3.32369273
27positive regulation of immune response to tumor cell (GO:0002839)3.29859690
28regulation of immune response to tumor cell (GO:0002837)3.29859690
29regulation of response to tumor cell (GO:0002834)3.29859690
30positive regulation of response to tumor cell (GO:0002836)3.29859690
31DNA double-strand break processing (GO:0000729)3.27871110
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.27711870
33L-fucose catabolic process (GO:0042355)3.16214638
34fucose catabolic process (GO:0019317)3.16214638
35L-fucose metabolic process (GO:0042354)3.16214638
36rRNA catabolic process (GO:0016075)3.14794445
37protein localization to Golgi apparatus (GO:0034067)3.10244981
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10109858
39DNA damage response, detection of DNA damage (GO:0042769)3.07736156
40mRNA cleavage (GO:0006379)3.02659578
41nucleotide transmembrane transport (GO:1901679)3.00219247
42response to interferon-beta (GO:0035456)2.99107055
43segment specification (GO:0007379)2.98661341
44energy coupled proton transport, down electrochemical gradient (GO:0015985)2.98611836
45ATP synthesis coupled proton transport (GO:0015986)2.98611836
46pattern specification involved in kidney development (GO:0061004)2.98170018
47ribosome biogenesis (GO:0042254)2.93834674
48branched-chain amino acid catabolic process (GO:0009083)2.93196237
49chaperone mediated protein folding requiring cofactor (GO:0051085)2.91789774
50protein complex biogenesis (GO:0070271)2.90770199
51water-soluble vitamin biosynthetic process (GO:0042364)2.89555842
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.89004243
53positive regulation of cellular response to oxidative stress (GO:1900409)2.88946506
54positive regulation of response to oxidative stress (GO:1902884)2.88946506
55proteasome assembly (GO:0043248)2.86598528
56positive regulation of T-helper 1 type immune response (GO:0002827)2.86323687
57C-terminal protein lipidation (GO:0006501)2.85212510
58telomere maintenance via telomerase (GO:0007004)2.83090012
59nonmotile primary cilium assembly (GO:0035058)2.80511727
60anatomical structure regression (GO:0060033)2.80316497
61mitochondrial respiratory chain complex assembly (GO:0033108)2.79534794
62prenylation (GO:0097354)2.78039638
63protein prenylation (GO:0018342)2.78039638
64retinal ganglion cell axon guidance (GO:0031290)2.77591493
65DNA deamination (GO:0045006)2.77425685
66phosphatidylserine acyl-chain remodeling (GO:0036150)2.76420825
67regulation of cellular amino acid metabolic process (GO:0006521)2.76238334
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75901057
69regulation of transcription regulatory region DNA binding (GO:2000677)2.75385560
70dendritic spine morphogenesis (GO:0060997)2.74802075
71regulation of glomerular filtration (GO:0003093)2.72530961
72negative regulation of reactive oxygen species metabolic process (GO:2000378)2.71664594
73forebrain neuron differentiation (GO:0021879)2.70571006
74biotin metabolic process (GO:0006768)2.69373121
75ubiquinone biosynthetic process (GO:0006744)2.66564778
76positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.63019085
77C-terminal protein amino acid modification (GO:0018410)2.62347960
78respiratory chain complex IV assembly (GO:0008535)2.61200920
79positive regulation of fibroblast migration (GO:0010763)2.60240825
80retrograde transport, vesicle recycling within Golgi (GO:0000301)2.60149374
81regulation of urine volume (GO:0035809)2.59731893
82protein targeting to Golgi (GO:0000042)2.59354647
83axoneme assembly (GO:0035082)2.56899416
84positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.56480522
85establishment of protein localization to Golgi (GO:0072600)2.56208152
86intraciliary transport (GO:0042073)2.55992136
87cellular component biogenesis (GO:0044085)2.50824071
88nucleotide-excision repair, DNA damage removal (GO:0000718)2.49651336
89DNA excision (GO:0044349)2.49651336
90positive regulation of hormone metabolic process (GO:0032352)2.49262730
91photoreceptor cell development (GO:0042461)2.49213957
92parental behavior (GO:0060746)2.46617504
93endothelium development (GO:0003158)2.44833150
94positive regulation of protein sumoylation (GO:0033235)2.44485636
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.44276304
96ubiquinone metabolic process (GO:0006743)2.43975841
97RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.43618655
98maternal behavior (GO:0042711)2.42034109
99single strand break repair (GO:0000012)2.41318170
100phosphatidylinositol acyl-chain remodeling (GO:0036149)2.40775206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.69110911
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.48569859
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.19999643
4EZH2_22144423_ChIP-Seq_EOC_Human3.32657961
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.18049153
6ZNF274_21170338_ChIP-Seq_K562_Hela3.17796828
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.97951474
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.90097209
9PCGF2_27294783_Chip-Seq_NPCs_Mouse2.71322437
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71204095
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.69004567
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37460380
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37095405
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29191159
15VDR_23849224_ChIP-Seq_CD4+_Human2.12316580
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04772042
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01810648
18ELK1_19687146_ChIP-ChIP_HELA_Human1.92526180
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.84662233
20NOTCH1_21737748_ChIP-Seq_TLL_Human1.83681693
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.77988020
22AR_21572438_ChIP-Seq_LNCaP_Human1.71444998
23IRF1_19129219_ChIP-ChIP_H3396_Human1.68297786
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.66690878
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64544359
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64129373
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59284362
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59282347
29EWS_26573619_Chip-Seq_HEK293_Human1.57830855
30TP53_22573176_ChIP-Seq_HFKS_Human1.57638829
31MYC_18555785_ChIP-Seq_MESCs_Mouse1.51640322
32FOXP3_21729870_ChIP-Seq_TREG_Human1.49290645
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.47981163
34MYC_18940864_ChIP-ChIP_HL60_Human1.47547245
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.45935411
36GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44266937
37GBX2_23144817_ChIP-Seq_PC3_Human1.43575124
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42431147
39P300_19829295_ChIP-Seq_ESCs_Human1.41277035
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40641715
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38039599
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36475988
43CBP_20019798_ChIP-Seq_JUKART_Human1.36475988
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35114799
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.34031718
46ER_23166858_ChIP-Seq_MCF-7_Human1.30072299
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29168560
48FUS_26573619_Chip-Seq_HEK293_Human1.25847099
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25074620
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25011740
51NCOR_22424771_ChIP-Seq_293T_Human1.24986072
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22827710
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22727851
54GABP_19822575_ChIP-Seq_HepG2_Human1.22266387
55SOX2_19829295_ChIP-Seq_ESCs_Human1.19351956
56NANOG_19829295_ChIP-Seq_ESCs_Human1.19351956
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18923495
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18178080
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17417111
60HOXB7_26014856_ChIP-Seq_BT474_Human1.14069540
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13931061
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13281564
63GATA1_22025678_ChIP-Seq_K562_Human1.11093734
64LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08021261
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07877213
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.07865211
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05650765
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05487725
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.03591570
70P53_22387025_ChIP-Seq_ESCs_Mouse1.03561251
71TAF15_26573619_Chip-Seq_HEK293_Human1.03421414
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02955267
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02615040
74IGF1R_20145208_ChIP-Seq_DFB_Human1.02464131
75AR_20517297_ChIP-Seq_VCAP_Human0.99850105
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99566832
77BCAT_22108803_ChIP-Seq_LS180_Human0.96043609
78FOXA1_25329375_ChIP-Seq_VCAP_Human0.95050220
79FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95050220
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94095573
81CRX_20693478_ChIP-Seq_RETINA_Mouse0.93637124
82HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92277800
83BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91924770
84SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.91726359
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91376093
86TTF2_22483619_ChIP-Seq_HELA_Human0.90351673
87TCF4_22108803_ChIP-Seq_LS180_Human0.89626449
88YY1_21170310_ChIP-Seq_MESCs_Mouse0.88670655
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86886430
90TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86184896
91MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85752025
92ELF5_23300383_ChIP-Seq_T47D_Human0.85368196
93MYC_19829295_ChIP-Seq_ESCs_Human0.84700160
94POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83716071
95UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83493142
96SUZ12_18555785_Chip-Seq_ESCs_Mouse0.82844260
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.82709709
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.81256861
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81127044
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80677476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.61232679
2MP0000372_irregular_coat_pigmentation3.72488756
3MP0001984_abnormal_olfaction2.99274934
4MP0006072_abnormal_retinal_apoptosis2.95195543
5MP0002163_abnormal_gland_morphology2.66139229
6MP0001188_hyperpigmentation2.64123046
7MP0003136_yellow_coat_color2.63671247
8MP0005075_abnormal_melanosome_morpholog2.63596373
9MP0008058_abnormal_DNA_repair2.55064040
10MP0002102_abnormal_ear_morphology2.38756310
11MP0003183_abnormal_peptide_metabolism2.35268126
12MP0005499_abnormal_olfactory_system2.31853958
13MP0005394_taste/olfaction_phenotype2.31853958
14MP0002938_white_spotting2.25080563
15MP0001529_abnormal_vocalization2.07424385
16MP0006276_abnormal_autonomic_nervous1.79736662
17MP0002638_abnormal_pupillary_reflex1.74603320
18MP0003172_abnormal_lysosome_physiology1.72000372
19MP0003195_calcinosis1.68759407
20MP0001970_abnormal_pain_threshold1.63122354
21MP0001293_anophthalmia1.63087237
22MP0004742_abnormal_vestibular_system1.62053616
23MP0001968_abnormal_touch/_nociception1.58496340
24MP0005084_abnormal_gallbladder_morpholo1.56025521
25MP0004142_abnormal_muscle_tone1.54231706
26MP0005379_endocrine/exocrine_gland_phen1.54158808
27MP0005551_abnormal_eye_electrophysiolog1.53101778
28MP0008995_early_reproductive_senescence1.51495240
29MP0002928_abnormal_bile_duct1.48736977
30MP0004133_heterotaxia1.48527251
31MP0001485_abnormal_pinna_reflex1.47643348
32MP0005645_abnormal_hypothalamus_physiol1.47471686
33MP0004147_increased_porphyrin_level1.44139585
34MP0004885_abnormal_endolymph1.41819414
35MP0002736_abnormal_nociception_after1.37219925
36MP0005253_abnormal_eye_physiology1.36646683
37MP0002733_abnormal_thermal_nociception1.33941955
38MP0009384_cardiac_valve_regurgitation1.30182357
39MP0009780_abnormal_chondrocyte_physiolo1.29560640
40MP0000778_abnormal_nervous_system1.26650186
41MP0005377_hearing/vestibular/ear_phenot1.25221194
42MP0003878_abnormal_ear_physiology1.25221194
43MP0002272_abnormal_nervous_system1.25125371
44MP0000049_abnormal_middle_ear1.24114833
45MP0002166_altered_tumor_susceptibility1.24108367
46MP0010386_abnormal_urinary_bladder1.21245727
47MP0006292_abnormal_olfactory_placode1.20213653
48MP0001905_abnormal_dopamine_level1.17495047
49MP0008789_abnormal_olfactory_epithelium1.17326080
50MP0008875_abnormal_xenobiotic_pharmacok1.15280512
51MP0003890_abnormal_embryonic-extraembry1.12847492
52MP0006054_spinal_hemorrhage1.09751788
53MP0001986_abnormal_taste_sensitivity1.09096789
54MP0004381_abnormal_hair_follicle1.08115844
55MP0003567_abnormal_fetal_cardiomyocyte1.08101096
56MP0002876_abnormal_thyroid_physiology1.05662153
57MP0005367_renal/urinary_system_phenotyp1.05055606
58MP0000516_abnormal_urinary_system1.05055606
59MP0001881_abnormal_mammary_gland1.04801002
60MP0005332_abnormal_amino_acid1.04533725
61MP0005387_immune_system_phenotype1.04249717
62MP0001790_abnormal_immune_system1.04249717
63MP0008872_abnormal_physiological_respon1.01426140
64MP0002557_abnormal_social/conspecific_i1.00135329
65MP0002063_abnormal_learning/memory/cond0.98173880
66MP0001486_abnormal_startle_reflex0.97616161
67MP0003718_maternal_effect0.97233777
68MP0008877_abnormal_DNA_methylation0.96531153
69MP0008775_abnormal_heart_ventricle0.96266753
70MP0000631_abnormal_neuroendocrine_gland0.95180730
71MP0002572_abnormal_emotion/affect_behav0.94313516
72MP0009745_abnormal_behavioral_response0.94103939
73MP0005410_abnormal_fertilization0.93966876
74MP0002006_tumorigenesis0.93478422
75MP0010368_abnormal_lymphatic_system0.92844944
76MP0001324_abnormal_eye_pigmentation0.89156212
77MP0002752_abnormal_somatic_nervous0.89121881
78MP0005220_abnormal_exocrine_pancreas0.88211761
79MP0001286_abnormal_eye_development0.88159832
80MP0002067_abnormal_sensory_capabilities0.87015802
81MP0005391_vision/eye_phenotype0.86324095
82MP0001879_abnormal_lymphatic_vessel0.85580142
83MP0000613_abnormal_salivary_gland0.84744134
84MP0004924_abnormal_behavior0.84026992
85MP0005386_behavior/neurological_phenoty0.84026992
86MP0003936_abnormal_reproductive_system0.83887247
87MP0005195_abnormal_posterior_eye0.82549073
88MP0000383_abnormal_hair_follicle0.82473164
89MP0002734_abnormal_mechanical_nocicepti0.81998801
90MP0002837_dystrophic_cardiac_calcinosis0.81757278
91MP0004145_abnormal_muscle_electrophysio0.79631255
92MP0003137_abnormal_impulse_conducting0.78000059
93MP0002184_abnormal_innervation0.77761333
94MP0000026_abnormal_inner_ear0.77239676
95MP0000358_abnormal_cell_content/0.77214023
96MP0002751_abnormal_autonomic_nervous0.75385063
97MP0005389_reproductive_system_phenotype0.73800088
98MP0000653_abnormal_sex_gland0.70552203
99MP0002210_abnormal_sex_determination0.69056398
100MP0003937_abnormal_limbs/digits/tail_de0.66309107

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.02590263
2Molar tooth sign on MRI (HP:0002419)4.22176218
3Abnormality of midbrain morphology (HP:0002418)4.22176218
4Nephronophthisis (HP:0000090)4.07358660
5Type II lissencephaly (HP:0007260)3.74804442
6Abnormality of the renal medulla (HP:0100957)3.70291046
7Type I transferrin isoform profile (HP:0003642)3.56769376
8Abolished electroretinogram (ERG) (HP:0000550)3.53976969
9Abnormality of DNA repair (HP:0003254)3.33175978
10Dyschromatopsia (HP:0007641)3.31579796
11Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.90130321
12Abnormal protein N-linked glycosylation (HP:0012347)2.90130321
13Abnormal protein glycosylation (HP:0012346)2.90130321
14Abnormal glycosylation (HP:0012345)2.90130321
15Abnormality of the labia minora (HP:0012880)2.80560663
16Pachygyria (HP:0001302)2.79059455
17Acute encephalopathy (HP:0006846)2.78073927
18Acute necrotizing encephalopathy (HP:0006965)2.77875079
19Pancreatic fibrosis (HP:0100732)2.75391292
20Medial flaring of the eyebrow (HP:0010747)2.71401478
21Aplasia/Hypoplasia of the spleen (HP:0010451)2.68992673
22Pancreatic cysts (HP:0001737)2.68317010
23Abnormality of dental color (HP:0011073)2.67851260
24Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63610882
25Abnormality of alanine metabolism (HP:0010916)2.63610882
26Hyperalaninemia (HP:0003348)2.63610882
27Sensorimotor neuropathy (HP:0007141)2.61285472
28Decreased electroretinogram (ERG) amplitude (HP:0000654)2.59826537
29Oligodactyly (hands) (HP:0001180)2.53603518
30Azoospermia (HP:0000027)2.52814432
31Congenital, generalized hypertrichosis (HP:0004540)2.46588280
32Bile duct proliferation (HP:0001408)2.46570380
33Abnormal biliary tract physiology (HP:0012439)2.46570380
34Cerebellar dysplasia (HP:0007033)2.45684266
35Abnormality of the renal cortex (HP:0011035)2.44935177
36Decreased circulating renin level (HP:0003351)2.43549725
37Lissencephaly (HP:0001339)2.42909968
38Mitochondrial inheritance (HP:0001427)2.39495898
39Progressive macrocephaly (HP:0004481)2.38112601
40Congenital stationary night blindness (HP:0007642)2.37834301
41Horseshoe kidney (HP:0000085)2.31607402
42Increased CSF lactate (HP:0002490)2.28221429
43Asplenia (HP:0001746)2.27982458
44Esophageal atresia (HP:0002032)2.26826799
45Abnormal rod and cone electroretinograms (HP:0008323)2.24570223
46Congenital primary aphakia (HP:0007707)2.20404129
47Genetic anticipation (HP:0003743)2.19472546
48Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18743151
49Optic disc pallor (HP:0000543)2.17171018
50Lethargy (HP:0001254)2.16522770
51Gait imbalance (HP:0002141)2.13282106
52Tubular atrophy (HP:0000092)2.12108845
53Abnormal mitochondria in muscle tissue (HP:0008316)2.10715995
54Cerebral edema (HP:0002181)2.10385522
55Aplasia/Hypoplasia of the sternum (HP:0006714)2.07412549
56Nephrogenic diabetes insipidus (HP:0009806)2.07039564
57Chorioretinal atrophy (HP:0000533)2.05869344
58True hermaphroditism (HP:0010459)2.01954534
59Gastrointestinal atresia (HP:0002589)2.00742680
60Oligodactyly (HP:0012165)1.97566463
61Genital tract atresia (HP:0001827)1.96991979
62Poor coordination (HP:0002370)1.96933610
63Entropion (HP:0000621)1.96135378
64Aplasia/hypoplasia of the uterus (HP:0008684)1.94945869
65Adactyly (HP:0009776)1.92198776
66Deep palmar crease (HP:0006191)1.90924178
67Pendular nystagmus (HP:0012043)1.90418605
68Narrow forehead (HP:0000341)1.90065125
69Double outlet right ventricle (HP:0001719)1.89644198
70Congenital malformation of the right heart (HP:0011723)1.89644198
71Testicular atrophy (HP:0000029)1.88264425
72Abnormality of incisor morphology (HP:0011063)1.87819411
73Autoamputation (HP:0001218)1.86770564
74Abnormality of the aortic arch (HP:0012303)1.86081616
75Increased serum lactate (HP:0002151)1.83752330
76Abnormality of the axillary hair (HP:0100134)1.83507443
77Abnormality of secondary sexual hair (HP:0009888)1.83507443
78Optic nerve hypoplasia (HP:0000609)1.83209286
79Vaginal atresia (HP:0000148)1.82366985
80Diastasis recti (HP:0001540)1.81725933
81Reticulocytopenia (HP:0001896)1.81672760
82Ectopic kidney (HP:0000086)1.80713800
83Fair hair (HP:0002286)1.80026548
84Hypoalbuminemia (HP:0003073)1.79809229
85Abnormal albumin level (HP:0012116)1.79809229
86Renal hypoplasia (HP:0000089)1.78201319
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78165444
88Macrocytic anemia (HP:0001972)1.77756560
89Lactic acidosis (HP:0003128)1.76627289
90Anhidrosis (HP:0000970)1.76128006
91Vitreoretinal degeneration (HP:0000655)1.75449413
92Hyperammonemia (HP:0001987)1.73397674
93Cystic liver disease (HP:0006706)1.70307857
94Bulbous nose (HP:0000414)1.70231361
95Colon cancer (HP:0003003)1.70058029
96Poikiloderma (HP:0001029)1.69169590
97Bilateral microphthalmos (HP:0007633)1.69158715
98Brushfield spots (HP:0001088)1.68567537
99Increased circulating renin level (HP:0000848)1.68291018
100Hypophosphatemic rickets (HP:0004912)1.67493570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK165.25119549
2EIF2AK13.87929645
3TRIM282.88417927
4WNK42.82570785
5TSSK62.72507889
6EIF2AK32.61370302
7MKNK22.45022173
8ADRBK22.37242914
9MST42.22269602
10AKT32.13672367
11TLK12.10776563
12KIT2.09621813
13TIE12.07940930
14ZAK2.06893766
15PLK42.05175245
16CASK1.93572265
17MKNK11.79606165
18WNK31.73068025
19BMPR1B1.70922750
20NUAK11.66607685
21STK391.53174093
22MATK1.50820494
23NLK1.47978281
24BCKDK1.46822525
25PRKD31.46627450
26GRK11.37409582
27TGFBR11.32708391
28CDK81.31292986
29MAPKAPK31.27620754
30OXSR11.26698467
31PINK11.19558964
32EPHA31.17225521
33FES1.16286500
34BCR1.16120595
35SRPK11.14118834
36NTRK11.12758841
37TAOK31.12277238
38CAMKK21.02783029
39TYRO31.00847542
40PDK20.99893201
41TEC0.98178738
42FRK0.96165340
43PASK0.95852445
44EIF2AK20.94873661
45EPHB10.88003789
46EPHA40.85208592
47ALK0.84427105
48IRAK40.81515335
49JAK30.80324953
50TYK20.79439048
51MAP2K60.77881359
52RPS6KA50.75338140
53TAOK20.71794460
54CSNK1G10.71789733
55NTRK30.70638107
56BRAF0.69695871
57MAP3K110.69125729
58PRKCQ0.68911672
59PHKG20.65765931
60PHKG10.65765931
61TAOK10.62070608
62DMPK0.61990382
63ITK0.60331509
64MAP3K40.59208813
65CSNK1G30.56748719
66DYRK20.54898692
67TAF10.54871086
68CSNK1A1L0.52993782
69CLK10.51784970
70TGFBR20.50305757
71FER0.49336609
72CSNK1G20.48029341
73IKBKE0.47864932
74PIM20.44388421
75VRK10.44310742
76INSRR0.43260059
77MAP3K140.42018830
78PRKCG0.41609143
79CAMK1D0.40584737
80MAP3K30.38325024
81ATR0.34412614
82PLK30.33206075
83IGF1R0.30971399
84TXK0.30923704
85PRKCE0.30870899
86CSNK1A10.30363009
87CSNK1D0.30069352
88MAP2K70.29920350
89AURKB0.28785919
90ATM0.27168232
91MOS0.27065188
92SGK4940.27010882
93SGK2230.27010882
94MARK10.26201370
95MAPK70.25691875
96PNCK0.25149524
97SGK10.24469111
98CSNK2A20.23617960
99NEK10.23333450
100EPHB20.22165280

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.27285186
2Proteasome_Homo sapiens_hsa030503.48230610
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.40901003
4Ribosome_Homo sapiens_hsa030102.74666449
5Linoleic acid metabolism_Homo sapiens_hsa005912.73203926
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54023482
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.52484822
8Oxidative phosphorylation_Homo sapiens_hsa001902.49460087
9Parkinsons disease_Homo sapiens_hsa050122.33894886
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24343286
11Propanoate metabolism_Homo sapiens_hsa006402.20168458
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19307517
13Steroid biosynthesis_Homo sapiens_hsa001002.11939797
14Protein export_Homo sapiens_hsa030602.10631670
15Basal transcription factors_Homo sapiens_hsa030222.09143768
16Butanoate metabolism_Homo sapiens_hsa006502.08477959
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98340236
18Homologous recombination_Homo sapiens_hsa034401.91481813
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.87284490
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.78649420
21Nucleotide excision repair_Homo sapiens_hsa034201.77449534
22RNA degradation_Homo sapiens_hsa030181.76106560
23beta-Alanine metabolism_Homo sapiens_hsa004101.58196548
24Peroxisome_Homo sapiens_hsa041461.58048066
25Ether lipid metabolism_Homo sapiens_hsa005651.55572823
26Huntingtons disease_Homo sapiens_hsa050161.49123977
27Sulfur metabolism_Homo sapiens_hsa009201.41509672
28Mismatch repair_Homo sapiens_hsa034301.40053878
29Caffeine metabolism_Homo sapiens_hsa002321.37782656
30One carbon pool by folate_Homo sapiens_hsa006701.32098167
31Spliceosome_Homo sapiens_hsa030401.28898222
32Regulation of autophagy_Homo sapiens_hsa041401.26086914
33Fat digestion and absorption_Homo sapiens_hsa049751.24629636
34Alzheimers disease_Homo sapiens_hsa050101.24117725
35Arachidonic acid metabolism_Homo sapiens_hsa005901.21978944
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20748353
37RNA polymerase_Homo sapiens_hsa030201.14747383
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.14095014
39Fatty acid metabolism_Homo sapiens_hsa012121.11616894
40Chemical carcinogenesis_Homo sapiens_hsa052041.11055880
41Base excision repair_Homo sapiens_hsa034101.09685654
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03418855
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99156836
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99048943
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98440682
46Vitamin digestion and absorption_Homo sapiens_hsa049770.98057940
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95953778
48Nicotine addiction_Homo sapiens_hsa050330.89227574
49Allograft rejection_Homo sapiens_hsa053300.87269408
50Selenocompound metabolism_Homo sapiens_hsa004500.87082328
51Arginine and proline metabolism_Homo sapiens_hsa003300.86974361
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.86351435
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84632692
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82769805
55Purine metabolism_Homo sapiens_hsa002300.75690128
56Non-homologous end-joining_Homo sapiens_hsa034500.72683514
57Morphine addiction_Homo sapiens_hsa050320.72185679
58Tryptophan metabolism_Homo sapiens_hsa003800.68614832
59RNA transport_Homo sapiens_hsa030130.67777536
60Fanconi anemia pathway_Homo sapiens_hsa034600.66742516
61Fatty acid degradation_Homo sapiens_hsa000710.65939103
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64828591
63Ovarian steroidogenesis_Homo sapiens_hsa049130.64671281
64Autoimmune thyroid disease_Homo sapiens_hsa053200.60900635
65Cardiac muscle contraction_Homo sapiens_hsa042600.58558981
66Dorso-ventral axis formation_Homo sapiens_hsa043200.58205873
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57736409
68Metabolic pathways_Homo sapiens_hsa011000.55353082
69Pancreatic secretion_Homo sapiens_hsa049720.51124376
70Glutamatergic synapse_Homo sapiens_hsa047240.47832653
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47196666
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46951668
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46694674
74N-Glycan biosynthesis_Homo sapiens_hsa005100.46090431
75Pyruvate metabolism_Homo sapiens_hsa006200.44839857
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43460670
77Taste transduction_Homo sapiens_hsa047420.42902972
78Systemic lupus erythematosus_Homo sapiens_hsa053220.41775727
79Fatty acid elongation_Homo sapiens_hsa000620.40382735
80GABAergic synapse_Homo sapiens_hsa047270.39392925
81Pyrimidine metabolism_Homo sapiens_hsa002400.38235018
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37511929
83Glycerolipid metabolism_Homo sapiens_hsa005610.32630827
84Phototransduction_Homo sapiens_hsa047440.32014790
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.29995469
86Type I diabetes mellitus_Homo sapiens_hsa049400.29484527
87p53 signaling pathway_Homo sapiens_hsa041150.28527402
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26849107
89Serotonergic synapse_Homo sapiens_hsa047260.26576249
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.24236155
91Graft-versus-host disease_Homo sapiens_hsa053320.23846887
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22248806
93Asthma_Homo sapiens_hsa053100.22094555
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.21861527
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.21063946
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.20718625
97Cholinergic synapse_Homo sapiens_hsa047250.20349994
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19377889
99Olfactory transduction_Homo sapiens_hsa047400.19237537
100Circadian entrainment_Homo sapiens_hsa047130.18965299

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