ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.29969945
2	behavioral response to nicotine (GO:0035095)	4.95165336
3	cytidine deamination (GO:0009972)	4.26542028
4	cytidine metabolic process (GO:0046087)	4.26542028
5	cytidine catabolic process (GO:0006216)	4.26542028
6	L-methionine salvage (GO:0071267)	4.04958927
7	L-methionine biosynthetic process (GO:0071265)	4.04958927
8	amino acid salvage (GO:0043102)	4.04958927
9	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.03355346
10	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.02235488
11	NADH dehydrogenase complex assembly (GO:0010257)	4.02235488
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.02235488
13	preassembly of GPI anchor in ER membrane (GO:0016254)	4.00691736
14	fucose catabolic process (GO:0019317)	3.80200554
15	L-fucose metabolic process (GO:0042354)	3.80200554
16	L-fucose catabolic process (GO:0042355)	3.80200554
17	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.76849783
18	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.75111446
19	protein complex biogenesis (GO:0070271)	3.74243639
20	protein polyglutamylation (GO:0018095)	3.67801400
21	ubiquinone biosynthetic process (GO:0006744)	3.65464442
22	mannosylation (GO:0097502)	3.59228504
23	protein deneddylation (GO:0000338)	3.56857539
24	piRNA metabolic process (GO:0034587)	3.52326718
25	pseudouridine synthesis (GO:0001522)	3.49932262
26	proteasome assembly (GO:0043248)	3.46745805
27	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42165728
28	synaptic transmission, cholinergic (GO:0007271)	3.40653551
29	protein neddylation (GO:0045116)	3.39505033
30	ubiquinone metabolic process (GO:0006743)	3.34112722
31	metallo-sulfur cluster assembly (GO:0031163)	3.32647416
32	iron-sulfur cluster assembly (GO:0016226)	3.32647416
33	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.31942056
34	positive regulation of defense response to virus by host (GO:0002230)	3.31636617
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.24364406
36	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.14187481
37	base-excision repair, AP site formation (GO:0006285)	3.13370354
38	chaperone mediated protein folding requiring cofactor (GO:0051085)	3.12596167
39	rRNA catabolic process (GO:0016075)	3.12322160
40	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.06862922
41	cullin deneddylation (GO:0010388)	3.06505327
42	aldehyde catabolic process (GO:0046185)	3.04816990
43	multicellular organism reproduction (GO:0032504)	3.04707830
44	positive regulation of T-helper 1 type immune response (GO:0002827)	2.97683602
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.97093289
46	regulation of cellular amino acid metabolic process (GO:0006521)	2.93685651
47	negative regulation by host of viral transcription (GO:0043922)	2.92470396
48	S-adenosylmethionine metabolic process (GO:0046500)	2.91458422
49	maturation of 5.8S rRNA (GO:0000460)	2.91019874
50	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.90946612
51	quinone biosynthetic process (GO:1901663)	2.88289828
52	retinal cone cell development (GO:0046549)	2.86810589
53	water-soluble vitamin biosynthetic process (GO:0042364)	2.86676200
54	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.85279876
55	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.85279876
56	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.83114772
57	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.83114772
58	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.83114772
59	regulation of mitochondrial translation (GO:0070129)	2.79960135
60	peptidyl-histidine modification (GO:0018202)	2.78293401
61	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.78058262
62	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.78058262
63	meiotic cell cycle (GO:0051321)	2.77394187
64	positive regulation of protein homodimerization activity (GO:0090073)	2.75111066
65	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.74893696
66	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.71837508
67	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.71837508
68	replicative senescence (GO:0090399)	2.70861181
69	C-terminal protein amino acid modification (GO:0018410)	2.70743042
70	drug catabolic process (GO:0042737)	2.70541193
71	adaptation of signaling pathway (GO:0023058)	2.68582737
72	rRNA modification (GO:0000154)	2.68073579
73	male meiosis I (GO:0007141)	2.67630608
74	methionine biosynthetic process (GO:0009086)	2.67512361
75	auditory receptor cell stereocilium organization (GO:0060088)	2.67057584
76	C-terminal protein lipidation (GO:0006501)	2.66458773
77	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.66018251
78	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.65616693
79	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.63732194
80	GPI anchor metabolic process (GO:0006505)	2.63717829
81	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.61464097
82	DNA methylation involved in gamete generation (GO:0043046)	2.61099006
83	protein import into peroxisome matrix (GO:0016558)	2.58888325
84	response to pheromone (GO:0019236)	2.56537102
85	methionine metabolic process (GO:0006555)	2.56495441
86	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.55652243
87	GPI anchor biosynthetic process (GO:0006506)	2.54673472
88	cellular response to interleukin-15 (GO:0071350)	2.54432452
89	rRNA methylation (GO:0031167)	2.54387549
90	platelet dense granule organization (GO:0060155)	2.54358171
91	regulation of immunoglobulin secretion (GO:0051023)	2.51438026
92	electron transport chain (GO:0022900)	2.51107693
93	tRNA processing (GO:0008033)	2.49825223
94	respiratory chain complex IV assembly (GO:0008535)	2.49397472
95	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.49247074
96	seminiferous tubule development (GO:0072520)	2.47980088
97	cellular response to nicotine (GO:0071316)	2.47785570
98	ribosome biogenesis (GO:0042254)	2.47681741
99	pattern specification involved in kidney development (GO:0061004)	2.45191327
100	respiratory electron transport chain (GO:0022904)	2.44284316

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.50694799
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.53092659
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.36948420
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.06980227
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.01214650
6	VDR_22108803_ChIP-Seq_LS180_Human	3.00312330
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.97606739
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.95333642
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.93990560
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.89069590
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.71211401
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.67888174
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36275916
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.28528115
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.25620034
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16016595
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.09742081
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.04750230
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.98489986
20	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.92511034
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.86175994
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.85735468
23	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.83021145
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.80296710
25	TP53_22573176_ChIP-Seq_HFKS_Human	1.79360120
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.76868106
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73220182
28	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.71273205
29	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.67857613
30	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.57136990
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53855374
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.53198862
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46807132
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.41632981
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.41027032
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.40093995
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40093995
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.38160169
39	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.37238365
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36373618
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.34073395
42	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.30964603
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28193279
44	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28102782
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.27905207
46	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.27055376
47	AR_20517297_ChIP-Seq_VCAP_Human	1.26155687
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26103686
49	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25348458
50	EWS_26573619_Chip-Seq_HEK293_Human	1.25055238
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24544749
52	ER_23166858_ChIP-Seq_MCF-7_Human	1.22911894
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.21477012
54	FUS_26573619_Chip-Seq_HEK293_Human	1.18784941
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17567426
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17567426
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.13947506
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.13947506
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.12458003
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10338963
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09683163
62	NCOR_22424771_ChIP-Seq_293T_Human	1.09190433
63	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08337395
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.07808998
65	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07370012
66	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.05778913
67	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.05629583
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.05275274
69	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04361974
70	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.03784586
71	TAF15_26573619_Chip-Seq_HEK293_Human	1.02874715
72	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.02864866
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02662231
74	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02524758
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01353625
76	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.00691511
77	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00513617
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00325203
79	GATA3_26560356_Chip-Seq_TH1_Human	1.00184687
80	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00116731
81	ERA_21632823_ChIP-Seq_H3396_Human	0.99212513
82	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.98602284
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.98327431
84	STAT1_20625510_ChIP-Seq_HELA_Human	0.97842870
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96978673
86	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.96207785
87	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.94909890
88	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.93773145
89	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93670167
90	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.93617275
91	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.93349925
92	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.92649555
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91978240
94	OCT4_20526341_ChIP-Seq_ESCs_Human	0.89781945
95	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.89422750
96	GATA3_26560356_Chip-Seq_TH2_Human	0.88841682
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.88808458
98	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.88156576
99	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88013431
100	BCL6_27268052_Chip-Seq_Bcells_Human	0.87018670

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	4.43996832
2	MP0002138_abnormal_hepatobiliary_system	2.94883578
3	MP0006292_abnormal_olfactory_placode	2.93815468
4	MP0008789_abnormal_olfactory_epithelium	2.86767972
5	MP0008877_abnormal_DNA_methylation	2.85271584
6	MP0003718_maternal_effect	2.68694012
7	MP0006276_abnormal_autonomic_nervous	2.65417695
8	MP0003787_abnormal_imprinting	2.63929850
9	MP0001529_abnormal_vocalization	2.52482633
10	MP0005394_taste/olfaction_phenotype	2.38768917
11	MP0005499_abnormal_olfactory_system	2.38768917
12	MP0003646_muscle_fatigue	2.32697521
13	MP0002234_abnormal_pharynx_morphology	2.26937797
14	MP0002102_abnormal_ear_morphology	2.26834052
15	MP0005551_abnormal_eye_electrophysiolog	2.16537014
16	MP0001986_abnormal_taste_sensitivity	2.12329555
17	MP0002638_abnormal_pupillary_reflex	2.03170641
18	MP0006072_abnormal_retinal_apoptosis	1.97935134
19	MP0005671_abnormal_response_to	1.96817772
20	MP0005645_abnormal_hypothalamus_physiol	1.95506126
21	MP0005360_urolithiasis	1.92380526
22	MP0001984_abnormal_olfaction	1.88416345
23	MP0002163_abnormal_gland_morphology	1.85366536
24	MP0008875_abnormal_xenobiotic_pharmacok	1.71837336
25	MP0001905_abnormal_dopamine_level	1.71556313
26	MP0002876_abnormal_thyroid_physiology	1.70158976
27	MP0004142_abnormal_muscle_tone	1.66184375
28	MP0005075_abnormal_melanosome_morpholog	1.66027551
29	MP0008775_abnormal_heart_ventricle	1.58679338
30	MP0000569_abnormal_digit_pigmentation	1.58124789
31	MP0008872_abnormal_physiological_respon	1.52395044
32	MP0004145_abnormal_muscle_electrophysio	1.49968172
33	MP0005377_hearing/vestibular/ear_phenot	1.46287011
34	MP0003878_abnormal_ear_physiology	1.46287011
35	MP0006036_abnormal_mitochondrial_physio	1.42083206
36	MP0002733_abnormal_thermal_nociception	1.41915876
37	MP0003879_abnormal_hair_cell	1.41609224
38	MP0000685_abnormal_immune_system	1.41184304
39	MP0002139_abnormal_hepatobiliary_system	1.38382563
40	MP0005379_endocrine/exocrine_gland_phen	1.35312665
41	MP0003011_delayed_dark_adaptation	1.33301014
42	MP0002653_abnormal_ependyma_morphology	1.32503846
43	MP0001835_abnormal_antigen_presentation	1.28851216
44	MP0004147_increased_porphyrin_level	1.28745351
45	MP0009785_altered_susceptibility_to	1.26183810
46	MP0005389_reproductive_system_phenotype	1.20282269
47	MP0001501_abnormal_sleep_pattern	1.19106920
48	MP0004924_abnormal_behavior	1.16548240
49	MP0005386_behavior/neurological_phenoty	1.16548240
50	MP0005253_abnormal_eye_physiology	1.13856553
51	MP0003195_calcinosis	1.13785239
52	MP0005410_abnormal_fertilization	1.13168758
53	MP0003890_abnormal_embryonic-extraembry	1.11763712
54	MP0009745_abnormal_behavioral_response	1.10665960
55	MP0002160_abnormal_reproductive_system	1.10508662
56	MP0001968_abnormal_touch/_nociception	1.09665730
57	MP0002272_abnormal_nervous_system	1.09285196
58	MP0004084_abnormal_cardiac_muscle	1.08236732
59	MP0005332_abnormal_amino_acid	1.07469945
60	MP0003806_abnormal_nucleotide_metabolis	1.02645285
61	MP0001790_abnormal_immune_system	0.96889523
62	MP0005387_immune_system_phenotype	0.96889523
63	MP0009046_muscle_twitch	0.96093425
64	MP0001502_abnormal_circadian_rhythm	0.94617486
65	MP0005395_other_phenotype	0.92504622
66	MP0001970_abnormal_pain_threshold	0.90212086
67	MP0003693_abnormal_embryo_hatching	0.90158286
68	MP0004043_abnormal_pH_regulation	0.90132173
69	MP0005423_abnormal_somatic_nervous	0.89197298
70	MP0009764_decreased_sensitivity_to	0.88634425
71	MP0004036_abnormal_muscle_relaxation	0.85010870
72	MP0002006_tumorigenesis	0.84927122
73	MP0010386_abnormal_urinary_bladder	0.84744266
74	MP0003786_premature_aging	0.83802445
75	MP0001881_abnormal_mammary_gland	0.83032531
76	MP0000427_abnormal_hair_cycle	0.81050542
77	MP0000613_abnormal_salivary_gland	0.80188479
78	MP0002067_abnormal_sensory_capabilities	0.79968738
79	MP0008995_early_reproductive_senescence	0.79508689
80	MP0001919_abnormal_reproductive_system	0.78904800
81	MP0003121_genomic_imprinting	0.78802232
82	MP0001293_anophthalmia	0.78744364
83	MP0002148_abnormal_hypersensitivity_rea	0.77890943
84	MP0003329_amyloid_beta_deposits	0.77754739
85	MP0003137_abnormal_impulse_conducting	0.77007019
86	MP0002572_abnormal_emotion/affect_behav	0.76353843
87	MP0001485_abnormal_pinna_reflex	0.76046582
88	MP0002751_abnormal_autonomic_nervous	0.75942751
89	MP0001764_abnormal_homeostasis	0.75725596
90	MP0005195_abnormal_posterior_eye	0.75315361
91	MP0001929_abnormal_gametogenesis	0.74450931
92	MP0005174_abnormal_tail_pigmentation	0.74405970
93	MP0002090_abnormal_vision	0.73961894
94	MP0002166_altered_tumor_susceptibility	0.73125315
95	MP0005365_abnormal_bile_salt	0.72740908
96	MP0002277_abnormal_respiratory_mucosa	0.70872336
97	MP0002752_abnormal_somatic_nervous	0.70129143
98	MP0002332_abnormal_exercise_endurance	0.69361538
99	MP0002735_abnormal_chemical_nociception	0.68651508
100	MP0002229_neurodegeneration	0.66999931

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	4.24462617
2	Abnormality of midbrain morphology (HP:0002418)	4.18300488
3	Molar tooth sign on MRI (HP:0002419)	4.18300488
4	Acute necrotizing encephalopathy (HP:0006965)	4.03833350
5	Stomatitis (HP:0010280)	3.95647586
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.78277717
7	Congenital stationary night blindness (HP:0007642)	3.67753407
8	Acute encephalopathy (HP:0006846)	3.48274932
9	Increased CSF lactate (HP:0002490)	3.44093359
10	Mitochondrial inheritance (HP:0001427)	3.38031602
11	Type II lissencephaly (HP:0007260)	3.35601541
12	Progressive macrocephaly (HP:0004481)	3.33375473
13	Pancreatic cysts (HP:0001737)	3.05194392
14	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.99497600
15	Abnormality of the labia minora (HP:0012880)	2.92572865
16	Hepatocellular necrosis (HP:0001404)	2.89988874
17	True hermaphroditism (HP:0010459)	2.88945304
18	IgG deficiency (HP:0004315)	2.85088428
19	Increased serum lactate (HP:0002151)	2.78460907
20	Abnormal rod and cone electroretinograms (HP:0008323)	2.77614559
21	Cerebral edema (HP:0002181)	2.76999301
22	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.67347489
23	Abnormality of alanine metabolism (HP:0010916)	2.67347489
24	Hyperalaninemia (HP:0003348)	2.67347489
25	Hepatic necrosis (HP:0002605)	2.58994368
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.57903532
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.52959410
28	Increased IgM level (HP:0003496)	2.51421736
29	Type I transferrin isoform profile (HP:0003642)	2.46337572
30	Generalized aminoaciduria (HP:0002909)	2.43688193
31	Hypophosphatemic rickets (HP:0004912)	2.43092717
32	Lactic acidosis (HP:0003128)	2.39308385
33	Pancreatic fibrosis (HP:0100732)	2.33867080
34	Abolished electroretinogram (ERG) (HP:0000550)	2.33727986
35	Abnormality of the pons (HP:0007361)	2.33256411
36	Methylmalonic aciduria (HP:0012120)	2.32022316
37	Congenital, generalized hypertrichosis (HP:0004540)	2.30684171
38	Delayed CNS myelination (HP:0002188)	2.28164822
39	Broad alveolar ridges (HP:0000187)	2.27845551
40	Fair hair (HP:0002286)	2.27819296
41	Medial flaring of the eyebrow (HP:0010747)	2.25974336
42	Increased intramyocellular lipid droplets (HP:0012240)	2.23507957
43	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.21258524
44	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.21258524
45	Progressive inability to walk (HP:0002505)	2.18910616
46	Septo-optic dysplasia (HP:0100842)	2.17733486
47	Nephronophthisis (HP:0000090)	2.17673616
48	Methylmalonic acidemia (HP:0002912)	2.16522764
49	Renal cortical cysts (HP:0000803)	2.15668396
50	Optic disc pallor (HP:0000543)	2.15270130
51	Failure to thrive in infancy (HP:0001531)	2.13025712
52	Retinal dysplasia (HP:0007973)	2.11828844
53	Progressive microcephaly (HP:0000253)	2.11128846
54	Agitation (HP:0000713)	2.10664300
55	IgA deficiency (HP:0002720)	2.09787836
56	Abnormality of the renal cortex (HP:0011035)	2.07337064
57	Abnormal protein glycosylation (HP:0012346)	2.07040638
58	Abnormal glycosylation (HP:0012345)	2.07040638
59	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.07040638
60	Abnormal protein N-linked glycosylation (HP:0012347)	2.07040638
61	Lethargy (HP:0001254)	2.06877368
62	Carpal bone hypoplasia (HP:0001498)	2.06618017
63	Chronic diarrhea (HP:0002028)	2.04791388
64	Inability to walk (HP:0002540)	2.03721460
65	Abnormal drinking behavior (HP:0030082)	2.01301818
66	Polydipsia (HP:0001959)	2.01301818
67	Cerebellar dysplasia (HP:0007033)	1.99856695
68	Arthropathy (HP:0003040)	1.99168079
69	Lissencephaly (HP:0001339)	1.97100925
70	Pachygyria (HP:0001302)	1.94537648
71	Chronic hepatic failure (HP:0100626)	1.94224150
72	Abnormality of dental color (HP:0011073)	1.92574390
73	Sclerocornea (HP:0000647)	1.92012304
74	Renal Fanconi syndrome (HP:0001994)	1.89286468
75	Respiratory failure (HP:0002878)	1.88817277
76	Exercise intolerance (HP:0003546)	1.88163018
77	Attenuation of retinal blood vessels (HP:0007843)	1.87497230
78	Abnormality of T cell number (HP:0011839)	1.86463239
79	Abnormality of the fovea (HP:0000493)	1.85308565
80	Absent thumb (HP:0009777)	1.85248395
81	T lymphocytopenia (HP:0005403)	1.83414119
82	Hypoplasia of the pons (HP:0012110)	1.81864932
83	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.80243508
84	Hypoplasia of the fovea (HP:0007750)	1.80243508
85	Cystic liver disease (HP:0006706)	1.80112292
86	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.79299104
87	Hypoproteinemia (HP:0003075)	1.78408492
88	CNS demyelination (HP:0007305)	1.77017955
89	Anhidrosis (HP:0000970)	1.76442808
90	Increased muscle lipid content (HP:0009058)	1.75394552
91	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.74899888
92	Type 2 muscle fiber atrophy (HP:0003554)	1.74049678
93	Abnormality of the renal medulla (HP:0100957)	1.73564722
94	Abnormality of the renal collecting system (HP:0004742)	1.73238002
95	Leukodystrophy (HP:0002415)	1.72869505
96	Abnormal albumin level (HP:0012116)	1.72118476
97	Hypoalbuminemia (HP:0003073)	1.72118476
98	Decreased central vision (HP:0007663)	1.70990852
99	Absent septum pellucidum (HP:0001331)	1.68325303
100	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.67585135

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	4.28810007
2	EIF2AK3	3.75366979
3	STK16	3.74732676
4	MAPKAPK3	3.30084604
5	ZAK	2.59920305
6	BMPR1B	2.58105901
7	TLK1	2.56189624
8	TAOK3	2.35850368
9	WNK4	2.35323603
10	ADRBK2	2.24921478
11	FRK	2.16770988
12	BCKDK	2.16542680
13	TSSK6	2.11968528
14	TRIM28	2.02043089
15	PHKG1	1.99452537
16	PHKG2	1.99452537
17	VRK2	1.94173265
18	EIF2AK1	1.88039027
19	PINK1	1.84315067
20	GRK1	1.66747244
21	OBSCN	1.66348607
22	CAMKK2	1.48354661
23	KDR	1.40081163
24	MAPKAPK5	1.39838353
25	WNK3	1.35857553
26	MST4	1.26414739
27	PLK4	1.21573415
28	FES	1.17856402
29	EPHA3	1.17250076
30	MAPK13	1.13151676
31	TEC	1.11091414
32	TXK	1.10822181
33	VRK1	1.10732267
34	TIE1	1.09060459
35	TAF1	1.08623940
36	EIF2AK2	1.06195558
37	OXSR1	1.05099808
38	CSNK1G3	1.04990292
39	NUAK1	1.03916225
40	PDK2	0.96713516
41	PIM2	0.94139268
42	MET	0.93938600
43	MAP3K4	0.93368317
44	ITK	0.91068084
45	CSNK1G2	0.90701872
46	STK39	0.88202423
47	PLK2	0.86450484
48	PRKCQ	0.86390932
49	PLK3	0.82607597
50	INSRR	0.79708618
51	CSNK1G1	0.78291412
52	MKNK1	0.75512611
53	MAP3K13	0.74915598
54	STK24	0.71592915
55	MAP2K7	0.70845260
56	KIT	0.70796836
57	PRKD3	0.70518511
58	DYRK2	0.70039266
59	MATK	0.67945890
60	PKN1	0.67311947
61	CSNK1A1L	0.66883837
62	NTRK1	0.66372828
63	CDK19	0.65128609
64	SYK	0.63045444
65	TRPM7	0.59173457
66	MAP4K1	0.58551799
67	PRKCI	0.57775183
68	MAP3K11	0.55264145
69	ARAF	0.51467395
70	RPS6KA5	0.49508009
71	NEK6	0.49209480
72	IKBKB	0.48651331
73	DYRK1B	0.48359980
74	MAP3K14	0.48286827
75	ERBB3	0.46843520
76	GRK5	0.42610121
77	TNK2	0.42322141
78	CAMK1	0.41919491
79	NLK	0.39284020
80	MAP2K6	0.38219158
81	BCR	0.38097527
82	ALK	0.37184338
83	SRPK1	0.37058647
84	CSNK1A1	0.36712662
85	CHUK	0.35390463
86	PRKCE	0.33610685
87	PRKCG	0.32552195
88	AURKA	0.30379877
89	RPS6KB2	0.30045636
90	CAMK2A	0.29181944
91	PRKACA	0.28132650
92	CHEK2	0.27599740
93	STK11	0.27300466
94	IGF1R	0.27019755
95	NTRK2	0.26522686
96	CDK8	0.26364223
97	PLK1	0.26123832
98	PRKCA	0.25658120
99	PRKCZ	0.24773838
100	CSNK2A2	0.23504999

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.68986225
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.95046860
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.82339999
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.51271796
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.47225699
6	Parkinsons disease_Homo sapiens_hsa05012	2.41972300
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.16105965
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14625134
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.04357962
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00262833
11	Propanoate metabolism_Homo sapiens_hsa00640	1.92684453
12	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.84075419
13	Basal transcription factors_Homo sapiens_hsa03022	1.82247415
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.82123522
15	Allograft rejection_Homo sapiens_hsa05330	1.79894427
16	RNA polymerase_Homo sapiens_hsa03020	1.79446790
17	Asthma_Homo sapiens_hsa05310	1.78170056
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.74220303
19	Protein export_Homo sapiens_hsa03060	1.66193897
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.62802571
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.57022352
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.56796559
23	Phototransduction_Homo sapiens_hsa04744	1.56074547
24	RNA degradation_Homo sapiens_hsa03018	1.55089963
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.51708797
26	Ribosome_Homo sapiens_hsa03010	1.49904624
27	Caffeine metabolism_Homo sapiens_hsa00232	1.48976360
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48382054
29	Huntingtons disease_Homo sapiens_hsa05016	1.47786550
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.46765943
31	Peroxisome_Homo sapiens_hsa04146	1.40597214
32	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.36716112
33	Alzheimers disease_Homo sapiens_hsa05010	1.35289942
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32651377
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.30961213
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30198867
37	Sulfur metabolism_Homo sapiens_hsa00920	1.29136715
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.26547192
39	Type I diabetes mellitus_Homo sapiens_hsa04940	1.25593548
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.24765678
41	Graft-versus-host disease_Homo sapiens_hsa05332	1.24124958
42	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20266010
43	Butanoate metabolism_Homo sapiens_hsa00650	1.16330075
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.15109390
45	Collecting duct acid secretion_Homo sapiens_hsa04966	1.13703405
46	Rheumatoid arthritis_Homo sapiens_hsa05323	1.11375802
47	RNA transport_Homo sapiens_hsa03013	1.09047593
48	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.07146907
49	One carbon pool by folate_Homo sapiens_hsa00670	1.04708745
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03174449
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.02639958
52	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01323173
53	Steroid biosynthesis_Homo sapiens_hsa00100	1.01299393
54	Regulation of autophagy_Homo sapiens_hsa04140	1.00270284
55	Homologous recombination_Homo sapiens_hsa03440	0.94922663
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.94058048
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92787229
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92716162
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86710421
60	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85207545
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.83230599
62	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.78671613
63	Fatty acid elongation_Homo sapiens_hsa00062	0.78623103
64	Retinol metabolism_Homo sapiens_hsa00830	0.77676777
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75316585
66	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.74281415
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67622310
68	Purine metabolism_Homo sapiens_hsa00230	0.66459426
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65534398
70	Metabolic pathways_Homo sapiens_hsa01100	0.65442779
71	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.65236614
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.63848510
73	Fanconi anemia pathway_Homo sapiens_hsa03460	0.63238620
74	Arginine biosynthesis_Homo sapiens_hsa00220	0.61855288
75	Spliceosome_Homo sapiens_hsa03040	0.60449725
76	Fat digestion and absorption_Homo sapiens_hsa04975	0.60246340
77	Olfactory transduction_Homo sapiens_hsa04740	0.59941066
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58082289
79	Fatty acid degradation_Homo sapiens_hsa00071	0.54448805
80	Base excision repair_Homo sapiens_hsa03410	0.52189963
81	Sulfur relay system_Homo sapiens_hsa04122	0.49469225
82	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.49336377
83	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.48039541
84	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.47506753
85	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.47403271
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43293088
87	Morphine addiction_Homo sapiens_hsa05032	0.42773474
88	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36748179
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.36265114
90	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.34234168
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34037967
92	Viral myocarditis_Homo sapiens_hsa05416	0.33748753
93	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.31575591
94	Nicotine addiction_Homo sapiens_hsa05033	0.31196935
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.30697497
96	Carbon metabolism_Homo sapiens_hsa01200	0.30680328
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.30046163
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.29594305
99	Salivary secretion_Homo sapiens_hsa04970	0.27597154
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.26246808

ST13P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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