ST13P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sarcomere organization (GO:0060297)7.29904919
2DNA deamination (GO:0045006)6.40262990
3negative regulation of nitric-oxide synthase activity (GO:0051001)5.95653900
4cytidine catabolic process (GO:0006216)5.25003244
5cytidine deamination (GO:0009972)5.25003244
6cytidine metabolic process (GO:0046087)5.25003244
7regulation of skeletal muscle contraction (GO:0014819)5.08550433
8ribonucleoprotein complex disassembly (GO:0032988)5.08366543
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.71342788
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.61133825
11organelle disassembly (GO:1903008)4.52621126
12iron-sulfur cluster assembly (GO:0016226)4.34600088
13metallo-sulfur cluster assembly (GO:0031163)4.34600088
14negative regulation of muscle hypertrophy (GO:0014741)4.32141090
15chaperone mediated protein folding requiring cofactor (GO:0051085)4.28705677
16negative regulation of protein localization to cell surface (GO:2000009)4.25421575
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.16721945
18regulation of action potential (GO:0098900)4.14573611
19plasma membrane repair (GO:0001778)4.09602961
20negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.07913015
21positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc4.05822278
22L-methionine salvage (GO:0071267)3.93504071
23L-methionine biosynthetic process (GO:0071265)3.93504071
24amino acid salvage (GO:0043102)3.93504071
25DNA demethylation (GO:0080111)3.90156823
26proteasome assembly (GO:0043248)3.85545830
27activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.80299796
28negative regulation by host of viral transcription (GO:0043922)3.73217026
29cell fate commitment involved in formation of primary germ layer (GO:0060795)3.68576153
30negative regulation of cardiac muscle tissue growth (GO:0055022)3.61504581
31negative regulation of heart growth (GO:0061117)3.61504581
32negative regulation of cardiac muscle hypertrophy (GO:0010614)3.58745055
33response to pheromone (GO:0019236)3.57786090
34negative regulation of potassium ion transmembrane transport (GO:1901380)3.55506623
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54775504
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.54775504
37NADH dehydrogenase complex assembly (GO:0010257)3.54775504
38negative regulation of monooxygenase activity (GO:0032769)3.54258736
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.47875537
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.47875537
41negative regulation of organelle assembly (GO:1902116)3.37454435
42positive regulation of defense response to virus by host (GO:0002230)3.35976357
43protein complex biogenesis (GO:0070271)3.34982171
44negative regulation of transcription regulatory region DNA binding (GO:2000678)3.27351364
45water-soluble vitamin biosynthetic process (GO:0042364)3.18637279
46protein refolding (GO:0042026)3.14888683
47DNA dealkylation (GO:0035510)3.14628373
48negative regulation of heart rate (GO:0010459)3.13096270
49mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.06205687
50preassembly of GPI anchor in ER membrane (GO:0016254)3.05120876
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02464444
52kynurenine metabolic process (GO:0070189)3.02021195
53single strand break repair (GO:0000012)3.00927286
54respiratory chain complex IV assembly (GO:0008535)2.99986721
55positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99234189
56negative regulation of mast cell activation (GO:0033004)2.98771426
57methionine biosynthetic process (GO:0009086)2.98589135
58positive regulation of uterine smooth muscle contraction (GO:0070474)2.94748087
59protein deneddylation (GO:0000338)2.94653323
60positive regulation of natural killer cell mediated immunity (GO:0002717)2.92437573
61mitochondrial respiratory chain complex assembly (GO:0033108)2.86830400
62indole-containing compound catabolic process (GO:0042436)2.85348574
63indolalkylamine catabolic process (GO:0046218)2.85348574
64tryptophan catabolic process (GO:0006569)2.85348574
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80591522
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79808420
67negative regulation of telomere maintenance (GO:0032205)2.77871766
68protein K6-linked ubiquitination (GO:0085020)2.75827245
69cytochrome complex assembly (GO:0017004)2.75498695
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74065487
71ATP synthesis coupled proton transport (GO:0015986)2.73792020
72energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73792020
73regulation of meiosis I (GO:0060631)2.73783142
74methionine metabolic process (GO:0006555)2.73398857
75mannosylation (GO:0097502)2.61884486
76postreplication repair (GO:0006301)2.61733138
77membrane raft organization (GO:0031579)2.61593592
78negative regulation of oxidoreductase activity (GO:0051354)2.61261093
79rRNA modification (GO:0000154)2.59992743
80positive regulation of monocyte chemotaxis (GO:0090026)2.59165364
81sequestering of actin monomers (GO:0042989)2.56318703
82epithelial cell differentiation involved in kidney development (GO:0035850)2.55257946
83pseudouridine synthesis (GO:0001522)2.53987471
84regulation of cellular amino acid metabolic process (GO:0006521)2.53150768
85oxidative demethylation (GO:0070989)2.53124218
86S-adenosylmethionine metabolic process (GO:0046500)2.52345492
87somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51366197
88somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51366197
89isotype switching (GO:0045190)2.51366197
90cellular response to interleukin-15 (GO:0071350)2.51264967
91pyrimidine nucleoside catabolic process (GO:0046135)2.50935054
92positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.50037413
93regulation of defense response to virus by host (GO:0050691)2.48699531
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48336788
95positive regulation of transforming growth factor beta production (GO:0071636)2.47820228
96behavioral response to nicotine (GO:0035095)2.47169742
97regulation of membrane repolarization (GO:0060306)2.45852258
98protein-cofactor linkage (GO:0018065)2.44975441
99positive regulation of T-helper 1 type immune response (GO:0002827)2.43638636
100L-fucose metabolic process (GO:0042354)2.43487902

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.97699140
2ZNF274_21170338_ChIP-Seq_K562_Hela3.58493637
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.46384761
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.89589239
5IGF1R_20145208_ChIP-Seq_DFB_Human2.72818203
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.69580862
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62795406
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.58594197
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58245615
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47917495
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.38879914
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32383214
13VDR_23849224_ChIP-Seq_CD4+_Human2.26113893
14ELK1_19687146_ChIP-ChIP_HELA_Human2.19299686
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.19295852
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17346744
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15802151
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.12003322
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04345768
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04178313
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04051082
22EWS_26573619_Chip-Seq_HEK293_Human2.03007535
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98938775
24TAF15_26573619_Chip-Seq_HEK293_Human1.96354041
25IRF1_19129219_ChIP-ChIP_H3396_Human1.94616092
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.93070267
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.92745780
28ER_23166858_ChIP-Seq_MCF-7_Human1.88252706
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87017925
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.85268918
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.76415668
32GBX2_23144817_ChIP-Seq_PC3_Human1.76353007
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.68079271
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.67705356
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62963576
36FOXP3_21729870_ChIP-Seq_TREG_Human1.62673947
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.61493704
38CBP_20019798_ChIP-Seq_JUKART_Human1.61493704
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49046399
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48108715
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46523214
42MYC_18940864_ChIP-ChIP_HL60_Human1.45798984
43TP53_22573176_ChIP-Seq_HFKS_Human1.44165706
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43107405
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.43027430
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.39921328
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39184019
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32324152
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31750524
50FUS_26573619_Chip-Seq_HEK293_Human1.29646642
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27933542
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.25902665
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25902665
54P300_19829295_ChIP-Seq_ESCs_Human1.24313724
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22841258
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21797727
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20022468
58AR_20517297_ChIP-Seq_VCAP_Human1.18966489
59GATA3_26560356_Chip-Seq_TH2_Human1.18824657
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17644786
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17617786
62GATA1_22025678_ChIP-Seq_K562_Human1.15722935
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15071485
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.15019279
65POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13230188
66TAF2_19829295_ChIP-Seq_ESCs_Human1.13088048
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.12815413
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12001494
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10014250
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09746037
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09090991
72NANOG_19829295_ChIP-Seq_ESCs_Human1.08990342
73SOX2_19829295_ChIP-Seq_ESCs_Human1.08990342
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08810425
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06970187
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05641618
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04226231
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03937764
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03585308
80HTT_18923047_ChIP-ChIP_STHdh_Human1.03166565
81KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.02144806
82KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.02144806
83KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.02144806
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01582713
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.01219295
86GATA3_27048872_Chip-Seq_THYMUS_Human1.00699237
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99593466
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98857643
89P53_22387025_ChIP-Seq_ESCs_Mouse0.98364681
90CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97786318
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97243934
92RNF2_27304074_Chip-Seq_NSC_Mouse0.97190594
93CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96185962
94NCOR_22424771_ChIP-Seq_293T_Human0.96104111
95TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94252003
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.93755691
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91985382
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91769644
99ERG_20517297_ChIP-Seq_VCAP_Human0.91162621
100SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90112066

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane5.68291336
2MP0002102_abnormal_ear_morphology5.24261766
3MP0005671_abnormal_response_to3.05669180
4MP0004084_abnormal_cardiac_muscle2.87153685
5MP0004145_abnormal_muscle_electrophysio2.80253891
6MP0000749_muscle_degeneration2.77157355
7MP0008789_abnormal_olfactory_epithelium2.64990592
8MP0005646_abnormal_pituitary_gland2.45938113
9MP0003011_delayed_dark_adaptation2.44978871
10MP0002837_dystrophic_cardiac_calcinosis2.25583030
11MP0009785_altered_susceptibility_to2.02938368
12MP0005645_abnormal_hypothalamus_physiol1.91754835
13MP0002138_abnormal_hepatobiliary_system1.89666339
14MP0002163_abnormal_gland_morphology1.87298072
15MP0008995_early_reproductive_senescence1.78476935
16MP0008058_abnormal_DNA_repair1.72984868
17MP0006292_abnormal_olfactory_placode1.71974785
18MP0003786_premature_aging1.71786997
19MP0008872_abnormal_physiological_respon1.71271889
20MP0002234_abnormal_pharynx_morphology1.68441245
21MP0005394_taste/olfaction_phenotype1.66622057
22MP0005499_abnormal_olfactory_system1.66622057
23MP0001485_abnormal_pinna_reflex1.59759867
24MP0008875_abnormal_xenobiotic_pharmacok1.55782262
25MP0005377_hearing/vestibular/ear_phenot1.54854648
26MP0003878_abnormal_ear_physiology1.54854648
27MP0005551_abnormal_eye_electrophysiolog1.52498095
28MP0005379_endocrine/exocrine_gland_phen1.41993809
29MP0003195_calcinosis1.38815436
30MP0001293_anophthalmia1.38542458
31MP0001968_abnormal_touch/_nociception1.37856484
32MP0008877_abnormal_DNA_methylation1.34566189
33MP0005075_abnormal_melanosome_morpholog1.33731972
34MP0004036_abnormal_muscle_relaxation1.31711080
35MP0008775_abnormal_heart_ventricle1.31246535
36MP0002751_abnormal_autonomic_nervous1.31236780
37MP0006072_abnormal_retinal_apoptosis1.27764297
38MP0006276_abnormal_autonomic_nervous1.24172697
39MP0003045_fibrosis1.18583346
40MP0001919_abnormal_reproductive_system1.14775664
41MP0005253_abnormal_eye_physiology1.13024024
42MP0001764_abnormal_homeostasis1.12945259
43MP0002148_abnormal_hypersensitivity_rea1.09367058
44MP0004142_abnormal_muscle_tone1.08317359
45MP0000569_abnormal_digit_pigmentation1.06937943
46MP0003866_abnormal_defecation1.05343802
47MP0001835_abnormal_antigen_presentation1.05246017
48MP0004215_abnormal_myocardial_fiber1.03782748
49MP0002876_abnormal_thyroid_physiology1.03015788
50MP0002736_abnormal_nociception_after1.02448100
51MP0003763_abnormal_thymus_physiology1.02286529
52MP0005389_reproductive_system_phenotype1.01239372
53MP0001873_stomach_inflammation1.00859213
54MP0009697_abnormal_copulation1.00274663
55MP0002095_abnormal_skin_pigmentation0.97137928
56MP0000751_myopathy0.96443048
57MP0000685_abnormal_immune_system0.96023304
58MP0001486_abnormal_startle_reflex0.95959632
59MP0001905_abnormal_dopamine_level0.93147465
60MP0003567_abnormal_fetal_cardiomyocyte0.91399065
61MP0004885_abnormal_endolymph0.90676180
62MP0006082_CNS_inflammation0.88323304
63MP0002166_altered_tumor_susceptibility0.87139736
64MP0000372_irregular_coat_pigmentation0.85192247
65MP0001529_abnormal_vocalization0.84290160
66MP0006035_abnormal_mitochondrial_morpho0.83700143
67MP0005330_cardiomyopathy0.82055673
68MP0005410_abnormal_fertilization0.81164764
69MP0002733_abnormal_thermal_nociception0.80737358
70MP0002938_white_spotting0.80560598
71MP0002972_abnormal_cardiac_muscle0.80445117
72MP0002277_abnormal_respiratory_mucosa0.80216039
73MP0005332_abnormal_amino_acid0.79919056
74MP0000049_abnormal_middle_ear0.78889946
75MP0005187_abnormal_penis_morphology0.77284205
76MP0003137_abnormal_impulse_conducting0.77178489
77MP0002160_abnormal_reproductive_system0.75895401
78MP0001440_abnormal_grooming_behavior0.75656120
79MP0002272_abnormal_nervous_system0.75523422
80MP0001188_hyperpigmentation0.75266651
81MP0001119_abnormal_female_reproductive0.74715800
82MP0003787_abnormal_imprinting0.73905621
83MP0005620_abnormal_muscle_contractility0.73421339
84MP0001800_abnormal_humoral_immune0.73353015
85MP0003186_abnormal_redox_activity0.71434145
86MP0004742_abnormal_vestibular_system0.70217701
87MP0003646_muscle_fatigue0.68684425
88MP0003718_maternal_effect0.68590480
89MP0003119_abnormal_digestive_system0.67648577
90MP0001664_abnormal_digestion0.67405121
91MP0009745_abnormal_behavioral_response0.66251026
92MP0004043_abnormal_pH_regulation0.65652733
93MP0001542_abnormal_bone_strength0.64990771
94MP0003828_pulmonary_edema0.63686043
95MP0003252_abnormal_bile_duct0.63489058
96MP0002928_abnormal_bile_duct0.63380132
97MP0006036_abnormal_mitochondrial_physio0.63374356
98MP0002723_abnormal_immune_serum0.62650664
99MP0003283_abnormal_digestive_organ0.62430362
100MP0004883_abnormal_blood_vessel0.62384258

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)4.89428835
2Renal cortical cysts (HP:0000803)4.86934890
3Muscle hypertrophy of the lower extremities (HP:0008968)4.68240551
4Absent rod-and cone-mediated responses on ERG (HP:0007688)3.84944345
5Exercise-induced muscle cramps (HP:0003710)3.76239418
6Hypoplasia of the thymus (HP:0000778)3.55897097
7Subaortic stenosis (HP:0001682)3.47893922
8Abnormality of the left ventricular outflow tract (HP:0011103)3.47893922
9Hypoproteinemia (HP:0003075)3.35752032
10Abnormality of the renal cortex (HP:0011035)3.30654840
11Hepatocellular necrosis (HP:0001404)3.30426312
12Pancreatic cysts (HP:0001737)3.29907033
13Keratoconus (HP:0000563)3.29063755
14Increased corneal curvature (HP:0100692)3.29063755
15Exercise-induced myalgia (HP:0003738)3.20721000
16Abolished electroretinogram (ERG) (HP:0000550)3.14477164
173-Methylglutaconic aciduria (HP:0003535)3.12237732
18Abnormality of midbrain morphology (HP:0002418)3.01152217
19Molar tooth sign on MRI (HP:0002419)3.01152217
20Mitochondrial inheritance (HP:0001427)2.90658213
21Constricted visual fields (HP:0001133)2.87693522
22Stomatitis (HP:0010280)2.87089232
23Abnormality of T cell number (HP:0011839)2.84012084
24T lymphocytopenia (HP:0005403)2.83564500
25Myotonia (HP:0002486)2.82409755
26Hepatic necrosis (HP:0002605)2.76996158
27Aplastic anemia (HP:0001915)2.75870203
28Increased CSF lactate (HP:0002490)2.73095152
29Progressive inability to walk (HP:0002505)2.71197193
30True hermaphroditism (HP:0010459)2.69779865
31Nephronophthisis (HP:0000090)2.63884947
32IgG deficiency (HP:0004315)2.63854502
33Tongue fasciculations (HP:0001308)2.62501564
34Abnormal rod and cone electroretinograms (HP:0008323)2.60819881
35Type 2 muscle fiber atrophy (HP:0003554)2.60772636
36Short tibia (HP:0005736)2.58022708
37Pancreatic fibrosis (HP:0100732)2.55902913
38Medial flaring of the eyebrow (HP:0010747)2.54239871
39Methylmalonic acidemia (HP:0002912)2.51797146
40Inability to walk (HP:0002540)2.49119540
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.48892228
42Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.48892228
43Attenuation of retinal blood vessels (HP:0007843)2.45573878
44Severe combined immunodeficiency (HP:0004430)2.43726625
45Thyroiditis (HP:0100646)2.41483149
46Increased serum lactate (HP:0002151)2.36581333
47Abnormal albumin level (HP:0012116)2.35382900
48Hypoalbuminemia (HP:0003073)2.35382900
49Aplasia/Hypoplasia of the tibia (HP:0005772)2.32525136
50Hyperglycinemia (HP:0002154)2.27383309
51Acute encephalopathy (HP:0006846)2.26903202
52Muscle fibrillation (HP:0010546)2.24885306
53Congenital stationary night blindness (HP:0007642)2.22929411
54Abnormal biliary tract physiology (HP:0012439)2.20844790
55Bile duct proliferation (HP:0001408)2.20844790
56Muscle fiber atrophy (HP:0100295)2.20496066
57Ulnar claw (HP:0001178)2.19605805
58Gaze-evoked nystagmus (HP:0000640)2.18940275
59Abnormality of eosinophils (HP:0001879)2.18511413
60Acute necrotizing encephalopathy (HP:0006965)2.17236609
61Sudden death (HP:0001699)2.15473969
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10414951
63Abnormality of the renal medulla (HP:0100957)2.09817928
64Abnormality of the prostate (HP:0008775)2.07447994
65Muscle stiffness (HP:0003552)2.07184125
66Panhypogammaglobulinemia (HP:0003139)2.05556841
67Lactic acidosis (HP:0003128)2.04620825
68Anhidrosis (HP:0000970)2.02966953
69Recurrent corneal erosions (HP:0000495)1.99433156
70Areflexia of lower limbs (HP:0002522)1.97560413
71Methylmalonic aciduria (HP:0012120)1.96210605
72Abnormality of T cells (HP:0002843)1.93341889
73Prostate neoplasm (HP:0100787)1.93040356
74Optic disc pallor (HP:0000543)1.90867441
75Increased hepatocellular lipid droplets (HP:0006565)1.90525179
76Thyroid-stimulating hormone excess (HP:0002925)1.89851422
77Facial diplegia (HP:0001349)1.87826611
78Renal Fanconi syndrome (HP:0001994)1.86840125
79Abnormal mitochondria in muscle tissue (HP:0008316)1.86483320
80Eosinophilia (HP:0001880)1.85513514
81Abnormality of macular pigmentation (HP:0008002)1.85486553
82Aplasia/Hypoplasia of the spleen (HP:0010451)1.84302907
83Increased intramyocellular lipid droplets (HP:0012240)1.84116579
84Abnormality of the anterior horn cell (HP:0006802)1.81655188
85Degeneration of anterior horn cells (HP:0002398)1.81655188
86Posterior subcapsular cataract (HP:0007787)1.81149220
87Lipid accumulation in hepatocytes (HP:0006561)1.81112455
88Poor suck (HP:0002033)1.81062306
89Progressive macrocephaly (HP:0004481)1.79279385
90Asymmetric septal hypertrophy (HP:0001670)1.78483617
91Prolonged QT interval (HP:0001657)1.78234670
92Asplenia (HP:0001746)1.76081916
93CNS demyelination (HP:0007305)1.75746561
94Encephalitis (HP:0002383)1.74951251
95Hemiparesis (HP:0001269)1.74791361
96Combined immunodeficiency (HP:0005387)1.74332241
97Decreased central vision (HP:0007663)1.73088004
98Abnormality of the labia minora (HP:0012880)1.70035085
99Abnormal delayed hypersensitivity skin test (HP:0002963)1.68850605
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68467950

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK54.92133478
2BMPR1B3.93835558
3BCKDK3.18214072
4CDK83.11935173
5TXK2.89617894
6TLK12.64887121
7NUAK12.47625399
8MAP4K22.40537052
9TAOK32.33947257
10VRK12.11838834
11MUSK2.06771488
12CCNB12.01324796
13VRK21.96165343
14MAPKAPK31.86089469
15FRK1.77682293
16STK38L1.77087144
17ZAK1.72082991
18ADRBK21.70538963
19KDR1.66136379
20GRK11.64841491
21TAF11.59836215
22TGFBR11.54459526
23MAP3K111.42701133
24CDK91.40155697
25BCR1.36665284
26MAP4K11.33761575
27ACVR1B1.29258407
28TEC1.16233372
29MAP3K121.11827170
30MAPK131.10041632
31TRIM281.07360151
32TNK21.05562110
33EIF2AK31.04614515
34WNK31.04431883
35MKNK10.99741293
36MATK0.99040022
37INSRR0.96092044
38SIK30.91401843
39DAPK10.91361392
40SIK20.88558261
41IKBKB0.87431780
42PLK20.86631750
43PRKCQ0.84705500
44PLK30.84511090
45SRPK10.82357147
46ITK0.82160531
47CSNK1G20.81995003
48PINK10.79414679
49PIK3CA0.78505644
50SYK0.78486291
51FES0.75294068
52CSNK1G30.71008459
53STK160.67028052
54LIMK10.66899968
55PHKG10.66602873
56PHKG20.66602873
57RPS6KA50.65829008
58SCYL20.65742379
59DMPK0.65532726
60KIT0.59492145
61PRKCE0.59392845
62TSSK60.59007233
63DYRK20.57957908
64MST40.57951650
65LCK0.57721808
66PRKCG0.57594223
67DAPK20.55820034
68GRK60.55225555
69MAP2K60.52647080
70TESK20.52584066
71STK240.52095002
72PKN10.51676876
73FLT30.51203980
74MAP3K40.49576713
75PLK10.49452961
76WNK40.49152574
77IGF1R0.49039852
78NTRK20.48397532
79MELK0.48119806
80MAP3K70.47481315
81EIF2AK20.47422607
82AURKA0.47356838
83TIE10.46117193
84RPS6KA40.45497820
85CSNK1G10.45386431
86MAP3K50.45043338
87FER0.44995396
88CSNK1A10.44676428
89IKBKE0.43784837
90STK390.43043467
91CSNK1D0.42890742
92MAPK70.42745722
93CSNK2A10.41670079
94CDK30.41644206
95MET0.39991737
96MKNK20.39976523
97EPHA30.39524313
98CSF1R0.39361024
99OBSCN0.39250314
100BTK0.38817594

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.39461071
2Primary immunodeficiency_Homo sapiens_hsa053403.15620382
3Protein export_Homo sapiens_hsa030603.02057211
4Oxidative phosphorylation_Homo sapiens_hsa001902.73038825
5Antigen processing and presentation_Homo sapiens_hsa046122.70566373
6Graft-versus-host disease_Homo sapiens_hsa053322.70195207
7Selenocompound metabolism_Homo sapiens_hsa004502.56381025
8Parkinsons disease_Homo sapiens_hsa050122.26236078
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06119789
10Linoleic acid metabolism_Homo sapiens_hsa005912.01002271
11Propanoate metabolism_Homo sapiens_hsa006401.95677707
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92578692
13Autoimmune thyroid disease_Homo sapiens_hsa053201.91573700
14Allograft rejection_Homo sapiens_hsa053301.87084230
15Type I diabetes mellitus_Homo sapiens_hsa049401.81480060
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76401185
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69574872
18RNA polymerase_Homo sapiens_hsa030201.67464642
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67318199
20Fatty acid elongation_Homo sapiens_hsa000621.63525790
21One carbon pool by folate_Homo sapiens_hsa006701.59745101
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55276153
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.51676765
24Basal transcription factors_Homo sapiens_hsa030221.51282942
25RNA degradation_Homo sapiens_hsa030181.49443361
26Nitrogen metabolism_Homo sapiens_hsa009101.46269103
27Cardiac muscle contraction_Homo sapiens_hsa042601.43426240
28Alzheimers disease_Homo sapiens_hsa050101.39986015
29Homologous recombination_Homo sapiens_hsa034401.39132204
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38278015
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37355301
32Asthma_Homo sapiens_hsa053101.33371524
33Huntingtons disease_Homo sapiens_hsa050161.31787872
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25527137
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.24099774
36Spliceosome_Homo sapiens_hsa030401.23158739
37Caffeine metabolism_Homo sapiens_hsa002321.19521914
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17510695
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.16940573
40Peroxisome_Homo sapiens_hsa041461.13799594
41Phototransduction_Homo sapiens_hsa047441.12278214
42Hematopoietic cell lineage_Homo sapiens_hsa046401.10736176
43Ether lipid metabolism_Homo sapiens_hsa005651.10734393
44Tryptophan metabolism_Homo sapiens_hsa003801.02654256
45Retinol metabolism_Homo sapiens_hsa008300.96765719
46Chemical carcinogenesis_Homo sapiens_hsa052040.96540727
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.93525576
48beta-Alanine metabolism_Homo sapiens_hsa004100.92020470
49Arachidonic acid metabolism_Homo sapiens_hsa005900.91283806
50Butanoate metabolism_Homo sapiens_hsa006500.88471142
51Rheumatoid arthritis_Homo sapiens_hsa053230.87042518
52Pyrimidine metabolism_Homo sapiens_hsa002400.85691746
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84466391
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82632893
55Fanconi anemia pathway_Homo sapiens_hsa034600.81241476
56Mismatch repair_Homo sapiens_hsa034300.77989850
57Viral myocarditis_Homo sapiens_hsa054160.77945579
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77507784
59Collecting duct acid secretion_Homo sapiens_hsa049660.77437437
60Pyruvate metabolism_Homo sapiens_hsa006200.77218184
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76972285
62Nicotine addiction_Homo sapiens_hsa050330.75896018
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.73394010
64RNA transport_Homo sapiens_hsa030130.73081757
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72798823
66Nucleotide excision repair_Homo sapiens_hsa034200.71909869
67Ribosome_Homo sapiens_hsa030100.70742836
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70494535
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69885433
70Taste transduction_Homo sapiens_hsa047420.68608825
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67527138
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66183930
73Purine metabolism_Homo sapiens_hsa002300.66084939
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64108218
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59318976
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57869700
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57644413
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57068692
79ABC transporters_Homo sapiens_hsa020100.55930416
80Regulation of autophagy_Homo sapiens_hsa041400.54840210
81Base excision repair_Homo sapiens_hsa034100.53510563
82Olfactory transduction_Homo sapiens_hsa047400.53073137
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52719866
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52224869
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.51775008
86Fat digestion and absorption_Homo sapiens_hsa049750.48306791
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47501937
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46273161
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44992597
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44848680
91Metabolic pathways_Homo sapiens_hsa011000.44726325
92Systemic lupus erythematosus_Homo sapiens_hsa053220.43123752
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41738337
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41451331
95Glycerolipid metabolism_Homo sapiens_hsa005610.38771515
96Ovarian steroidogenesis_Homo sapiens_hsa049130.37205545
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.30568768
98Salivary secretion_Homo sapiens_hsa049700.29362291
99Herpes simplex infection_Homo sapiens_hsa051680.27785249
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27291519

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