ST13P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribonucleoprotein complex disassembly (GO:0032988)6.23209188
2regulation of sarcomere organization (GO:0060297)6.03636876
3organelle disassembly (GO:1903008)6.00931812
4behavioral response to nicotine (GO:0035095)4.84289226
5DNA deamination (GO:0045006)4.78488861
6negative regulation of nitric-oxide synthase activity (GO:0051001)4.40466046
7protein-cofactor linkage (GO:0018065)4.21286335
8regulation of action potential (GO:0098900)4.17598406
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.99818912
10mitochondrial respiratory chain complex I assembly (GO:0032981)3.99818912
11NADH dehydrogenase complex assembly (GO:0010257)3.99818912
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.93911005
13iron-sulfur cluster assembly (GO:0016226)3.93602551
14metallo-sulfur cluster assembly (GO:0031163)3.93602551
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86715239
16ATP synthesis coupled proton transport (GO:0015986)3.86715239
17RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.86521805
18preassembly of GPI anchor in ER membrane (GO:0016254)3.84061899
19regulation of skeletal muscle contraction (GO:0014819)3.83429297
20protein complex biogenesis (GO:0070271)3.80511779
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.70409349
22amino acid salvage (GO:0043102)3.62520292
23L-methionine salvage (GO:0071267)3.62520292
24L-methionine biosynthetic process (GO:0071265)3.62520292
25ubiquinone biosynthetic process (GO:0006744)3.58967514
26mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.56945055
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.56838205
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54007144
29S-adenosylmethionine metabolic process (GO:0046500)3.53333849
30mitochondrial respiratory chain complex assembly (GO:0033108)3.44245941
31cell wall macromolecule catabolic process (GO:0016998)3.43406904
32protein deneddylation (GO:0000338)3.43303134
33ubiquinone metabolic process (GO:0006743)3.40716469
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40333580
35water-soluble vitamin biosynthetic process (GO:0042364)3.39020211
36positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.34954716
37cell fate commitment involved in formation of primary germ layer (GO:0060795)3.32699254
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31486103
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31486103
40postreplication repair (GO:0006301)3.30662750
41activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.25919665
42proteasome assembly (GO:0043248)3.24494302
43plasma membrane repair (GO:0001778)3.23228169
44mannosylation (GO:0097502)3.20446034
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.19275892
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16245475
47termination of RNA polymerase III transcription (GO:0006386)3.15577560
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.15577560
49base-excision repair, AP site formation (GO:0006285)3.13905886
50glyoxylate metabolic process (GO:0046487)3.09908006
51fucose catabolic process (GO:0019317)3.09626080
52L-fucose metabolic process (GO:0042354)3.09626080
53L-fucose catabolic process (GO:0042355)3.09626080
54regulation of cellular amino acid metabolic process (GO:0006521)3.06945728
55cellular ketone body metabolic process (GO:0046950)2.99731554
56regulation of cilium movement (GO:0003352)2.98196030
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94837819
58negative regulation of muscle hypertrophy (GO:0014741)2.93585434
59negative regulation of protein localization to cell surface (GO:2000009)2.92364065
60cullin deneddylation (GO:0010388)2.88690462
61cell wall macromolecule metabolic process (GO:0044036)2.87572001
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87483887
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87483887
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87483887
65quinone biosynthetic process (GO:1901663)2.87078536
66peptidyl-histidine modification (GO:0018202)2.84682466
67adenosine metabolic process (GO:0046085)2.84473675
68negative regulation of oligodendrocyte differentiation (GO:0048715)2.84285479
69rRNA modification (GO:0000154)2.83177577
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81647757
71signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81647757
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.80647132
73piRNA metabolic process (GO:0034587)2.78382040
74negative regulation of organelle assembly (GO:1902116)2.78078886
75protein polyglutamylation (GO:0018095)2.77318779
76spliceosomal complex assembly (GO:0000245)2.74917767
77rRNA methylation (GO:0031167)2.74441049
78electron transport chain (GO:0022900)2.74266993
79signal transduction involved in cell cycle checkpoint (GO:0072395)2.74082782
80methionine biosynthetic process (GO:0009086)2.73297383
81DNA ligation (GO:0006266)2.73049753
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.73027638
83pseudouridine synthesis (GO:0001522)2.72544362
84signal transduction involved in DNA damage checkpoint (GO:0072422)2.72312672
85signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72312672
86pyrimidine nucleobase catabolic process (GO:0006208)2.72107839
87maturation of 5.8S rRNA (GO:0000460)2.71991720
88chaperone-mediated protein transport (GO:0072321)2.71929333
89regulation of mitochondrial translation (GO:0070129)2.71729891
90respiratory electron transport chain (GO:0022904)2.71722273
91branched-chain amino acid catabolic process (GO:0009083)2.70732276
92pyrimidine nucleotide catabolic process (GO:0006244)2.68575362
93negative regulation of telomere maintenance (GO:0032205)2.66777217
94negative regulation of JAK-STAT cascade (GO:0046426)2.65460391
95oxidative demethylation (GO:0070989)2.63780840
96GPI anchor biosynthetic process (GO:0006506)2.63261056
97ketone body metabolic process (GO:1902224)2.61437565
98GPI anchor metabolic process (GO:0006505)2.60842812
99rRNA catabolic process (GO:0016075)2.59506998
100negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58373053

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.55403686
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.84232671
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81911115
4VDR_22108803_ChIP-Seq_LS180_Human3.76718741
5ZNF274_21170338_ChIP-Seq_K562_Hela3.34681366
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24628969
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.21951354
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89080224
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.72168878
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65932643
11ELK1_19687146_ChIP-ChIP_HELA_Human2.58640635
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55023537
13IGF1R_20145208_ChIP-Seq_DFB_Human2.54716883
14VDR_23849224_ChIP-Seq_CD4+_Human2.47255301
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.24536432
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.23257041
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15118030
18FOXP3_21729870_ChIP-Seq_TREG_Human2.05191242
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.01661640
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99475082
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94760123
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88948716
23GABP_19822575_ChIP-Seq_HepG2_Human1.87022236
24MYC_18940864_ChIP-ChIP_HL60_Human1.80692014
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.80128722
26EWS_26573619_Chip-Seq_HEK293_Human1.79136234
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.74853366
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.73576315
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69789411
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66409892
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65297741
32FUS_26573619_Chip-Seq_HEK293_Human1.61099128
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61057182
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59881045
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56480323
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54815077
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52963943
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50517587
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48452081
40MYC_18555785_ChIP-Seq_MESCs_Mouse1.45937943
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45930372
42TP53_22573176_ChIP-Seq_HFKS_Human1.43822349
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.39659831
44CIITA_25753668_ChIP-Seq_RAJI_Human1.39525809
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37157726
46CBP_20019798_ChIP-Seq_JUKART_Human1.37157726
47GBX2_23144817_ChIP-Seq_PC3_Human1.36608025
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35697754
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33382333
50IRF1_19129219_ChIP-ChIP_H3396_Human1.32117542
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31689745
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31629701
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.30335391
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26007039
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24106772
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.23777536
57DCP1A_22483619_ChIP-Seq_HELA_Human1.21707388
58EZH2_27294783_Chip-Seq_NPCs_Mouse1.21486196
59ER_23166858_ChIP-Seq_MCF-7_Human1.20500869
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20202142
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16277128
62TAF15_26573619_Chip-Seq_HEK293_Human1.16164929
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14760771
64NCOR_22424771_ChIP-Seq_293T_Human1.14156923
65TTF2_22483619_ChIP-Seq_HELA_Human1.12976957
66FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12970618
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12719928
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08888070
69P300_19829295_ChIP-Seq_ESCs_Human1.08722204
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08065806
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07727510
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04841714
73AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03488035
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02567052
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01455186
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00445460
77AR_20517297_ChIP-Seq_VCAP_Human0.98470641
78KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98209492
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98124542
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98077852
81P53_22387025_ChIP-Seq_ESCs_Mouse0.97516771
82RNF2_27304074_Chip-Seq_NSC_Mouse0.96782821
83STAT3_18555785_Chip-Seq_ESCs_Mouse0.96750725
84MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96654279
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95262289
86MYC_19829295_ChIP-Seq_ESCs_Human0.95065752
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94492516
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.94492516
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93421675
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93351167
91NANOG_19829295_ChIP-Seq_ESCs_Human0.92548716
92SOX2_19829295_ChIP-Seq_ESCs_Human0.92548716
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92301548
94TAF2_19829295_ChIP-Seq_ESCs_Human0.91984124
95E2F1_18555785_Chip-Seq_ESCs_Mouse0.91316340
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.91090238
97ERA_21632823_ChIP-Seq_H3396_Human0.87768623
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87044821
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.86452803
100CRX_20693478_ChIP-Seq_RETINA_Mouse0.86416441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.80027411
2MP0003950_abnormal_plasma_membrane3.39860012
3MP0005645_abnormal_hypothalamus_physiol3.20273634
4MP0008789_abnormal_olfactory_epithelium3.08835469
5MP0003878_abnormal_ear_physiology2.79687753
6MP0005377_hearing/vestibular/ear_phenot2.79687753
7MP0003787_abnormal_imprinting2.63639414
8MP0002138_abnormal_hepatobiliary_system2.54615522
9MP0005499_abnormal_olfactory_system2.44403786
10MP0005394_taste/olfaction_phenotype2.44403786
11MP0006292_abnormal_olfactory_placode2.40746763
12MP0001529_abnormal_vocalization2.34300275
13MP0005646_abnormal_pituitary_gland2.09092852
14MP0006072_abnormal_retinal_apoptosis2.01448053
15MP0008877_abnormal_DNA_methylation2.00719456
16MP0002653_abnormal_ependyma_morphology1.95686627
17MP0001485_abnormal_pinna_reflex1.94398241
18MP0003806_abnormal_nucleotide_metabolis1.88206125
19MP0008875_abnormal_xenobiotic_pharmacok1.86807108
20MP0001968_abnormal_touch/_nociception1.83119493
21MP0004145_abnormal_muscle_electrophysio1.77058484
22MP0008058_abnormal_DNA_repair1.69906836
23MP0002837_dystrophic_cardiac_calcinosis1.66200586
24MP0000372_irregular_coat_pigmentation1.65530469
25MP0004084_abnormal_cardiac_muscle1.63210494
26MP0008995_early_reproductive_senescence1.58651613
27MP0001905_abnormal_dopamine_level1.57899239
28MP0000749_muscle_degeneration1.57839163
29MP0002160_abnormal_reproductive_system1.52828082
30MP0006276_abnormal_autonomic_nervous1.50702058
31MP0005389_reproductive_system_phenotype1.49945665
32MP0005253_abnormal_eye_physiology1.49870243
33MP0003786_premature_aging1.45886974
34MP0000569_abnormal_digit_pigmentation1.44147581
35MP0003195_calcinosis1.41190437
36MP0008872_abnormal_physiological_respon1.41190083
37MP0001293_anophthalmia1.39250452
38MP0002736_abnormal_nociception_after1.38697931
39MP0005551_abnormal_eye_electrophysiolog1.36034367
40MP0001919_abnormal_reproductive_system1.34400067
41MP0004142_abnormal_muscle_tone1.31283362
42MP0001984_abnormal_olfaction1.29757200
43MP0001764_abnormal_homeostasis1.27438332
44MP0002751_abnormal_autonomic_nervous1.27104001
45MP0010386_abnormal_urinary_bladder1.25159587
46MP0003121_genomic_imprinting1.24951239
47MP0003880_abnormal_central_pattern1.23917354
48MP0001486_abnormal_startle_reflex1.23550112
49MP0002163_abnormal_gland_morphology1.23092863
50MP0002272_abnormal_nervous_system1.18813148
51MP0003718_maternal_effect1.17926625
52MP0008775_abnormal_heart_ventricle1.15816143
53MP0005075_abnormal_melanosome_morpholog1.12353432
54MP0001270_distended_abdomen1.11831334
55MP0009046_muscle_twitch1.09852597
56MP0004215_abnormal_myocardial_fiber1.08856694
57MP0002638_abnormal_pupillary_reflex1.03686912
58MP0002735_abnormal_chemical_nociception1.01568140
59MP0002822_catalepsy0.97823564
60MP0002733_abnormal_thermal_nociception0.95950907
61MP0000631_abnormal_neuroendocrine_gland0.94272249
62MP0005671_abnormal_response_to0.92774058
63MP0002876_abnormal_thyroid_physiology0.92593850
64MP0000647_abnormal_sebaceous_gland0.92389752
65MP0005195_abnormal_posterior_eye0.92347451
66MP0003693_abnormal_embryo_hatching0.89888320
67MP0002090_abnormal_vision0.89325622
68MP0005187_abnormal_penis_morphology0.88385579
69MP0005408_hypopigmentation0.87669716
70MP0009745_abnormal_behavioral_response0.87074403
71MP0000427_abnormal_hair_cycle0.84045079
72MP0002928_abnormal_bile_duct0.83038811
73MP0005220_abnormal_exocrine_pancreas0.82969718
74MP0001970_abnormal_pain_threshold0.81384598
75MP0002277_abnormal_respiratory_mucosa0.79878830
76MP0000685_abnormal_immune_system0.79876267
77MP0005386_behavior/neurological_phenoty0.79708854
78MP0004924_abnormal_behavior0.79708854
79MP0002752_abnormal_somatic_nervous0.78496610
80MP0003186_abnormal_redox_activity0.74948297
81MP0004147_increased_porphyrin_level0.74008120
82MP0002557_abnormal_social/conspecific_i0.73671079
83MP0002938_white_spotting0.72823644
84MP0005330_cardiomyopathy0.72808363
85MP0005360_urolithiasis0.72743330
86MP0000049_abnormal_middle_ear0.72742975
87MP0001986_abnormal_taste_sensitivity0.72434637
88MP0005391_vision/eye_phenotype0.71475882
89MP0009785_altered_susceptibility_to0.70883831
90MP0000026_abnormal_inner_ear0.70799540
91MP0002067_abnormal_sensory_capabilities0.70791851
92MP0008007_abnormal_cellular_replicative0.70768221
93MP0000778_abnormal_nervous_system0.70468937
94MP0009697_abnormal_copulation0.70444422
95MP0003011_delayed_dark_adaptation0.68977180
96MP0002734_abnormal_mechanical_nocicepti0.68949047
97MP0002572_abnormal_emotion/affect_behav0.68596283
98MP0002095_abnormal_skin_pigmentation0.67475337
99MP0005332_abnormal_amino_acid0.67021906
100MP0001440_abnormal_grooming_behavior0.66567404

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)4.42519493
2Calf muscle hypertrophy (HP:0008981)4.09352636
3Acute necrotizing encephalopathy (HP:0006965)3.77712023
4Abolished electroretinogram (ERG) (HP:0000550)3.69024817
5Muscle hypertrophy of the lower extremities (HP:0008968)3.59499514
6Exercise-induced muscle cramps (HP:0003710)3.51344746
7Mitochondrial inheritance (HP:0001427)3.40379566
8Hepatocellular necrosis (HP:0001404)3.32308545
9Abnormal mitochondria in muscle tissue (HP:0008316)3.30388145
10Increased CSF lactate (HP:0002490)3.29401145
11Progressive macrocephaly (HP:0004481)3.27075817
12Medial flaring of the eyebrow (HP:0010747)3.26638759
13Acute encephalopathy (HP:0006846)3.22660135
14Hepatic necrosis (HP:0002605)3.21837281
15Abnormality of the renal cortex (HP:0011035)3.17614013
16Abnormal protein glycosylation (HP:0012346)3.15832670
17Abnormal glycosylation (HP:0012345)3.15832670
18Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.15832670
19Abnormal protein N-linked glycosylation (HP:0012347)3.15832670
20Hyperglycinemia (HP:0002154)3.10786998
21Retinal dysplasia (HP:0007973)3.07860068
22Type I transferrin isoform profile (HP:0003642)3.03838915
23Tubulointerstitial nephritis (HP:0001970)3.03385782
24Type II lissencephaly (HP:0007260)3.01381514
25Inability to walk (HP:0002540)2.93598802
26Molar tooth sign on MRI (HP:0002419)2.90504979
27Abnormality of midbrain morphology (HP:0002418)2.90504979
28Brushfield spots (HP:0001088)2.84098484
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.69325586
30Constricted visual fields (HP:0001133)2.65168275
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61938567
32Pancreatic fibrosis (HP:0100732)2.59350637
33Increased serum pyruvate (HP:0003542)2.57337201
34Cerebral edema (HP:0002181)2.55211259
35Myotonia (HP:0002486)2.52881103
36Amelogenesis imperfecta (HP:0000705)2.51531161
37Pancreatic cysts (HP:0001737)2.50294352
38Increased serum lactate (HP:0002151)2.50004709
39Congenital, generalized hypertrichosis (HP:0004540)2.44822064
40Abnormality of the labia minora (HP:0012880)2.43235629
41True hermaphroditism (HP:0010459)2.42903760
423-Methylglutaconic aciduria (HP:0003535)2.42428111
43Pachygyria (HP:0001302)2.41806033
44Nephronophthisis (HP:0000090)2.37471916
45Aplastic anemia (HP:0001915)2.36032463
46Abnormality of alanine metabolism (HP:0010916)2.34849497
47Hyperalaninemia (HP:0003348)2.34849497
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34849497
49Optic disc pallor (HP:0000543)2.33717775
50Increased corneal curvature (HP:0100692)2.30391241
51Keratoconus (HP:0000563)2.30391241
52Lissencephaly (HP:0001339)2.25787281
53Increased hepatocellular lipid droplets (HP:0006565)2.24685715
54Lactic acidosis (HP:0003128)2.24267268
55Subaortic stenosis (HP:0001682)2.24225674
56Abnormality of the left ventricular outflow tract (HP:0011103)2.24225674
57Lipid accumulation in hepatocytes (HP:0006561)2.23344487
58Abnormal rod and cone electroretinograms (HP:0008323)2.23094140
59Tubular atrophy (HP:0000092)2.17750382
60Poor suck (HP:0002033)2.16992300
61Methylmalonic acidemia (HP:0002912)2.13444449
62Attenuation of retinal blood vessels (HP:0007843)2.12387815
63Congenital stationary night blindness (HP:0007642)2.11863492
64Lethargy (HP:0001254)2.11058249
65Abnormality of glycolysis (HP:0004366)2.10117680
66Congenital primary aphakia (HP:0007707)2.08565890
67Hyperglycinuria (HP:0003108)2.07519334
68Gait imbalance (HP:0002141)2.05701196
69Respiratory failure (HP:0002878)2.01539735
70Hypoplasia of the thymus (HP:0000778)2.00815704
71Exercise-induced myalgia (HP:0003738)1.99824123
72Optic nerve hypoplasia (HP:0000609)1.96960460
73Thyroid-stimulating hormone excess (HP:0002925)1.95535843
74Abnormality of the renal medulla (HP:0100957)1.94012786
75CNS demyelination (HP:0007305)1.93528462
76Nephrogenic diabetes insipidus (HP:0009806)1.91726012
77Abnormality of serine family amino acid metabolism (HP:0010894)1.91671200
78Abnormality of glycine metabolism (HP:0010895)1.91671200
79Abnormality of macular pigmentation (HP:0008002)1.90735033
80Prostate neoplasm (HP:0100787)1.88755174
81Polydipsia (HP:0001959)1.88024643
82Abnormal drinking behavior (HP:0030082)1.88024643
83Sudden death (HP:0001699)1.85188233
84Type 2 muscle fiber atrophy (HP:0003554)1.83588701
85Abnormality of serum amino acid levels (HP:0003112)1.82561166
86Atrophy/Degeneration involving motor neurons (HP:0007373)1.82548502
87Sclerocornea (HP:0000647)1.82305243
88Cerebral hypomyelination (HP:0006808)1.78681324
89Hypothermia (HP:0002045)1.78505054
90Neoplasm of the adrenal cortex (HP:0100641)1.78128362
91Redundant skin (HP:0001582)1.78077293
92Palpebral edema (HP:0100540)1.77639045
93Methylmalonic aciduria (HP:0012120)1.77355943
94Amyotrophic lateral sclerosis (HP:0007354)1.75579809
95Hypoproteinemia (HP:0003075)1.75425471
96Dry hair (HP:0011359)1.74591339
97Generalized aminoaciduria (HP:0002909)1.73209937
98Metaphyseal dysplasia (HP:0100255)1.72025442
99Barrel-shaped chest (HP:0001552)1.71688433
100Cerebellar dysplasia (HP:0007033)1.67886852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR1B3.63624642
2CDK83.27405512
3EIF2AK33.23104134
4ZAK3.20275611
5MAPKAPK53.06348050
6MAP4K23.05246061
7TLK12.65661121
8VRK22.54253800
9BCKDK2.38582996
10FRK2.25437749
11VRK12.25083603
12CCNB12.14549270
13ADRBK22.11900848
14WNK31.99559398
15STK161.99208361
16PINK11.70350479
17TXK1.67185890
18BCR1.59918735
19MUSK1.58383491
20DYRK21.47186917
21MAP2K71.45917914
22GRK11.43922251
23WNK41.40204942
24TGFBR11.36920665
25TAF11.32734125
26OXSR11.31744028
27TSSK61.17802095
28SCYL21.17437370
29PLK31.15905156
30MST41.15300915
31CDK91.15228311
32STK391.12690553
33MAP3K41.11560897
34MKNK11.11201151
35NUAK11.08357536
36SRPK11.06479594
37PLK21.06196189
38CDK191.04887477
39PIM21.01361756
40EIF2AK11.00097761
41NEK10.99887333
42CSNK1G30.97449886
43CSNK1G20.96415889
44DYRK30.92618726
45MAPKAPK30.90492430
46TRIM280.89956620
47TAOK30.88973270
48KIT0.88331964
49RPS6KA40.86494568
50RPS6KA50.84263737
51FLT30.83633809
52PLK40.74548206
53NTRK20.72679304
54PAK60.72512554
55MAP3K70.68029245
56PRKCG0.67583921
57PRKCE0.67261384
58CSNK1A1L0.66990524
59LIMK10.66524513
60CSNK1G10.65561142
61TIE10.63723658
62BUB10.59984369
63PLK10.59633803
64TEC0.59564724
65ERBB30.59504957
66SIK30.54868536
67KDR0.53513618
68AURKB0.52820648
69PHKG10.52168351
70PHKG20.52168351
71MKNK20.51028216
72DAPK30.49915612
73INSRR0.49537496
74DAPK10.49411575
75PRKACB0.49231229
76CASK0.48942789
77CSNK1A10.47450586
78ATR0.44393734
79AURKA0.44291406
80AKT30.42393042
81CSNK2A10.41505345
82DYRK1B0.40829395
83PKN10.40723201
84MARK10.40516719
85CAMK2A0.40162712
86CSNK1D0.39905645
87CAMK2D0.39790611
88CSNK2A20.39717424
89PRKCQ0.38411196
90DAPK20.37710260
91EIF2AK20.33163478
92EPHA30.32596930
93ADRBK10.31488529
94IGF1R0.31433896
95SYK0.31300338
96PRKACA0.29772581
97AKT20.29627375
98MAPK70.28775067
99OBSCN0.28203326
100MAPK130.28120645

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.75829260
2Oxidative phosphorylation_Homo sapiens_hsa001903.30393048
3Protein export_Homo sapiens_hsa030603.10371042
4Parkinsons disease_Homo sapiens_hsa050122.85581716
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73873416
6RNA polymerase_Homo sapiens_hsa030202.39862265
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.35066975
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.15877718
9Selenocompound metabolism_Homo sapiens_hsa004502.10311952
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03961135
11RNA degradation_Homo sapiens_hsa030181.94800268
12Propanoate metabolism_Homo sapiens_hsa006401.82240531
13Huntingtons disease_Homo sapiens_hsa050161.78299607
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75012138
15Alzheimers disease_Homo sapiens_hsa050101.70900240
16Butanoate metabolism_Homo sapiens_hsa006501.68661781
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65920795
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.64211517
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61821170
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60815696
21Cardiac muscle contraction_Homo sapiens_hsa042601.56879309
22Basal transcription factors_Homo sapiens_hsa030221.53764169
23Spliceosome_Homo sapiens_hsa030401.52816901
24Ribosome_Homo sapiens_hsa030101.51940083
25Peroxisome_Homo sapiens_hsa041461.51793808
26One carbon pool by folate_Homo sapiens_hsa006701.49781271
27Caffeine metabolism_Homo sapiens_hsa002321.42553670
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.41342661
29Nitrogen metabolism_Homo sapiens_hsa009101.39692040
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.39061154
31Base excision repair_Homo sapiens_hsa034101.38574354
32Linoleic acid metabolism_Homo sapiens_hsa005911.36842914
33Pyrimidine metabolism_Homo sapiens_hsa002401.32757236
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31510002
35Primary immunodeficiency_Homo sapiens_hsa053401.28661488
36Ether lipid metabolism_Homo sapiens_hsa005651.28564911
37Phototransduction_Homo sapiens_hsa047441.23966008
38Tryptophan metabolism_Homo sapiens_hsa003801.22440450
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19592981
40Mismatch repair_Homo sapiens_hsa034301.17624700
41Nucleotide excision repair_Homo sapiens_hsa034201.15103888
42Steroid biosynthesis_Homo sapiens_hsa001001.14647175
43Non-homologous end-joining_Homo sapiens_hsa034501.14140212
44Homologous recombination_Homo sapiens_hsa034401.14102627
45RNA transport_Homo sapiens_hsa030131.13128268
46beta-Alanine metabolism_Homo sapiens_hsa004101.11105824
47Pyruvate metabolism_Homo sapiens_hsa006201.08248656
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06573719
49Asthma_Homo sapiens_hsa053101.06321004
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06280809
51Fanconi anemia pathway_Homo sapiens_hsa034601.05735237
52Purine metabolism_Homo sapiens_hsa002301.04848193
53Systemic lupus erythematosus_Homo sapiens_hsa053220.98226974
54Sulfur relay system_Homo sapiens_hsa041220.96694100
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.96117651
56Collecting duct acid secretion_Homo sapiens_hsa049660.94422730
57Fatty acid elongation_Homo sapiens_hsa000620.90845057
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.88559652
59Type I diabetes mellitus_Homo sapiens_hsa049400.88517276
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86710174
61Antigen processing and presentation_Homo sapiens_hsa046120.85242077
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85029207
63Regulation of autophagy_Homo sapiens_hsa041400.84925275
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.79384619
65DNA replication_Homo sapiens_hsa030300.76087887
66Metabolic pathways_Homo sapiens_hsa011000.74431065
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72843751
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67849660
69Nicotine addiction_Homo sapiens_hsa050330.67306120
70Fatty acid degradation_Homo sapiens_hsa000710.63689775
71Graft-versus-host disease_Homo sapiens_hsa053320.63574824
72Arachidonic acid metabolism_Homo sapiens_hsa005900.63010762
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62781157
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61982493
75Sulfur metabolism_Homo sapiens_hsa009200.61640265
76Olfactory transduction_Homo sapiens_hsa047400.61623936
77Alcoholism_Homo sapiens_hsa050340.57652829
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56479443
79Allograft rejection_Homo sapiens_hsa053300.52125401
80p53 signaling pathway_Homo sapiens_hsa041150.49199860
81Rheumatoid arthritis_Homo sapiens_hsa053230.49089126
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48949848
83Carbon metabolism_Homo sapiens_hsa012000.47540609
84Arginine and proline metabolism_Homo sapiens_hsa003300.45459618
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.44332139
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42656169
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42297240
88Histidine metabolism_Homo sapiens_hsa003400.40959175
89Retinol metabolism_Homo sapiens_hsa008300.40876615
90Autoimmune thyroid disease_Homo sapiens_hsa053200.40616362
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38855323
92Biosynthesis of amino acids_Homo sapiens_hsa012300.36871425
93Synaptic vesicle cycle_Homo sapiens_hsa047210.35082000
94N-Glycan biosynthesis_Homo sapiens_hsa005100.34462203
95Fatty acid metabolism_Homo sapiens_hsa012120.33629741
96Chemical carcinogenesis_Homo sapiens_hsa052040.31003697
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28533376
98GABAergic synapse_Homo sapiens_hsa047270.28506984
99Morphine addiction_Homo sapiens_hsa050320.28238153
100Fat digestion and absorption_Homo sapiens_hsa049750.27324530

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