Rank | Gene Set | Z-score |
---|---|---|
1 | ribonucleoprotein complex disassembly (GO:0032988) | 6.23209188 |
2 | regulation of sarcomere organization (GO:0060297) | 6.03636876 |
3 | organelle disassembly (GO:1903008) | 6.00931812 |
4 | behavioral response to nicotine (GO:0035095) | 4.84289226 |
5 | DNA deamination (GO:0045006) | 4.78488861 |
6 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 4.40466046 |
7 | protein-cofactor linkage (GO:0018065) | 4.21286335 |
8 | regulation of action potential (GO:0098900) | 4.17598406 |
9 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.99818912 |
10 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.99818912 |
11 | NADH dehydrogenase complex assembly (GO:0010257) | 3.99818912 |
12 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.93911005 |
13 | iron-sulfur cluster assembly (GO:0016226) | 3.93602551 |
14 | metallo-sulfur cluster assembly (GO:0031163) | 3.93602551 |
15 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.86715239 |
16 | ATP synthesis coupled proton transport (GO:0015986) | 3.86715239 |
17 | RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503) | 3.86521805 |
18 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.84061899 |
19 | regulation of skeletal muscle contraction (GO:0014819) | 3.83429297 |
20 | protein complex biogenesis (GO:0070271) | 3.80511779 |
21 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.70409349 |
22 | amino acid salvage (GO:0043102) | 3.62520292 |
23 | L-methionine salvage (GO:0071267) | 3.62520292 |
24 | L-methionine biosynthetic process (GO:0071265) | 3.62520292 |
25 | ubiquinone biosynthetic process (GO:0006744) | 3.58967514 |
26 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.56945055 |
27 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.56838205 |
28 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.54007144 |
29 | S-adenosylmethionine metabolic process (GO:0046500) | 3.53333849 |
30 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.44245941 |
31 | cell wall macromolecule catabolic process (GO:0016998) | 3.43406904 |
32 | protein deneddylation (GO:0000338) | 3.43303134 |
33 | ubiquinone metabolic process (GO:0006743) | 3.40716469 |
34 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.40333580 |
35 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.39020211 |
36 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc | 3.34954716 |
37 | cell fate commitment involved in formation of primary germ layer (GO:0060795) | 3.32699254 |
38 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.31486103 |
39 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.31486103 |
40 | postreplication repair (GO:0006301) | 3.30662750 |
41 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO | 3.25919665 |
42 | proteasome assembly (GO:0043248) | 3.24494302 |
43 | plasma membrane repair (GO:0001778) | 3.23228169 |
44 | mannosylation (GO:0097502) | 3.20446034 |
45 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.19275892 |
46 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.16245475 |
47 | termination of RNA polymerase III transcription (GO:0006386) | 3.15577560 |
48 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.15577560 |
49 | base-excision repair, AP site formation (GO:0006285) | 3.13905886 |
50 | glyoxylate metabolic process (GO:0046487) | 3.09908006 |
51 | fucose catabolic process (GO:0019317) | 3.09626080 |
52 | L-fucose metabolic process (GO:0042354) | 3.09626080 |
53 | L-fucose catabolic process (GO:0042355) | 3.09626080 |
54 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.06945728 |
55 | cellular ketone body metabolic process (GO:0046950) | 2.99731554 |
56 | regulation of cilium movement (GO:0003352) | 2.98196030 |
57 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.94837819 |
58 | negative regulation of muscle hypertrophy (GO:0014741) | 2.93585434 |
59 | negative regulation of protein localization to cell surface (GO:2000009) | 2.92364065 |
60 | cullin deneddylation (GO:0010388) | 2.88690462 |
61 | cell wall macromolecule metabolic process (GO:0044036) | 2.87572001 |
62 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.87483887 |
63 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.87483887 |
64 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.87483887 |
65 | quinone biosynthetic process (GO:1901663) | 2.87078536 |
66 | peptidyl-histidine modification (GO:0018202) | 2.84682466 |
67 | adenosine metabolic process (GO:0046085) | 2.84473675 |
68 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 2.84285479 |
69 | rRNA modification (GO:0000154) | 2.83177577 |
70 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.81647757 |
71 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.81647757 |
72 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 2.80647132 |
73 | piRNA metabolic process (GO:0034587) | 2.78382040 |
74 | negative regulation of organelle assembly (GO:1902116) | 2.78078886 |
75 | protein polyglutamylation (GO:0018095) | 2.77318779 |
76 | spliceosomal complex assembly (GO:0000245) | 2.74917767 |
77 | rRNA methylation (GO:0031167) | 2.74441049 |
78 | electron transport chain (GO:0022900) | 2.74266993 |
79 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.74082782 |
80 | methionine biosynthetic process (GO:0009086) | 2.73297383 |
81 | DNA ligation (GO:0006266) | 2.73049753 |
82 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.73027638 |
83 | pseudouridine synthesis (GO:0001522) | 2.72544362 |
84 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.72312672 |
85 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.72312672 |
86 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.72107839 |
87 | maturation of 5.8S rRNA (GO:0000460) | 2.71991720 |
88 | chaperone-mediated protein transport (GO:0072321) | 2.71929333 |
89 | regulation of mitochondrial translation (GO:0070129) | 2.71729891 |
90 | respiratory electron transport chain (GO:0022904) | 2.71722273 |
91 | branched-chain amino acid catabolic process (GO:0009083) | 2.70732276 |
92 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.68575362 |
93 | negative regulation of telomere maintenance (GO:0032205) | 2.66777217 |
94 | negative regulation of JAK-STAT cascade (GO:0046426) | 2.65460391 |
95 | oxidative demethylation (GO:0070989) | 2.63780840 |
96 | GPI anchor biosynthetic process (GO:0006506) | 2.63261056 |
97 | ketone body metabolic process (GO:1902224) | 2.61437565 |
98 | GPI anchor metabolic process (GO:0006505) | 2.60842812 |
99 | rRNA catabolic process (GO:0016075) | 2.59506998 |
100 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.58373053 |
Rank | Gene Set | Z-score |
---|---|---|
1 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.55403686 |
2 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.84232671 |
3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.81911115 |
4 | VDR_22108803_ChIP-Seq_LS180_Human | 3.76718741 |
5 | ZNF274_21170338_ChIP-Seq_K562_Hela | 3.34681366 |
6 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.24628969 |
7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.21951354 |
8 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.89080224 |
9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.72168878 |
10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.65932643 |
11 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.58640635 |
12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.55023537 |
13 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.54716883 |
14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.47255301 |
15 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.24536432 |
16 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.23257041 |
17 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 2.15118030 |
18 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.05191242 |
19 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.01661640 |
20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.99475082 |
21 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.94760123 |
22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.88948716 |
23 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.87022236 |
24 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.80692014 |
25 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.80128722 |
26 | EWS_26573619_Chip-Seq_HEK293_Human | 1.79136234 |
27 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.74853366 |
28 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.73576315 |
29 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.69789411 |
30 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.66409892 |
31 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.65297741 |
32 | FUS_26573619_Chip-Seq_HEK293_Human | 1.61099128 |
33 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.61057182 |
34 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.59881045 |
35 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.56480323 |
36 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.54815077 |
37 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.52963943 |
38 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.50517587 |
39 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.48452081 |
40 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.45937943 |
41 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.45930372 |
42 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.43822349 |
43 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.39659831 |
44 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.39525809 |
45 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.37157726 |
46 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.37157726 |
47 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.36608025 |
48 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.35697754 |
49 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.33382333 |
50 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.32117542 |
51 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.31689745 |
52 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.31629701 |
53 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.30335391 |
54 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.26007039 |
55 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.24106772 |
56 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.23777536 |
57 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.21707388 |
58 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.21486196 |
59 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.20500869 |
60 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.20202142 |
61 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.16277128 |
62 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.16164929 |
63 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.14760771 |
64 | NCOR_22424771_ChIP-Seq_293T_Human | 1.14156923 |
65 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.12976957 |
66 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.12970618 |
67 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.12719928 |
68 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.08888070 |
69 | P300_19829295_ChIP-Seq_ESCs_Human | 1.08722204 |
70 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.08065806 |
71 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.07727510 |
72 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.04841714 |
73 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.03488035 |
74 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.02567052 |
75 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.01455186 |
76 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.00445460 |
77 | AR_20517297_ChIP-Seq_VCAP_Human | 0.98470641 |
78 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.98209492 |
79 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.98124542 |
80 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.98077852 |
81 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.97516771 |
82 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.96782821 |
83 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 0.96750725 |
84 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 0.96654279 |
85 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 0.95262289 |
86 | MYC_19829295_ChIP-Seq_ESCs_Human | 0.95065752 |
87 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.94492516 |
88 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.94492516 |
89 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 0.93421675 |
90 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.93351167 |
91 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.92548716 |
92 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.92548716 |
93 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92301548 |
94 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.91984124 |
95 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.91316340 |
96 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 0.91090238 |
97 | ERA_21632823_ChIP-Seq_H3396_Human | 0.87768623 |
98 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.87044821 |
99 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 0.86452803 |
100 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.86416441 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002102_abnormal_ear_morphology | 4.80027411 |
2 | MP0003950_abnormal_plasma_membrane | 3.39860012 |
3 | MP0005645_abnormal_hypothalamus_physiol | 3.20273634 |
4 | MP0008789_abnormal_olfactory_epithelium | 3.08835469 |
5 | MP0003878_abnormal_ear_physiology | 2.79687753 |
6 | MP0005377_hearing/vestibular/ear_phenot | 2.79687753 |
7 | MP0003787_abnormal_imprinting | 2.63639414 |
8 | MP0002138_abnormal_hepatobiliary_system | 2.54615522 |
9 | MP0005499_abnormal_olfactory_system | 2.44403786 |
10 | MP0005394_taste/olfaction_phenotype | 2.44403786 |
11 | MP0006292_abnormal_olfactory_placode | 2.40746763 |
12 | MP0001529_abnormal_vocalization | 2.34300275 |
13 | MP0005646_abnormal_pituitary_gland | 2.09092852 |
14 | MP0006072_abnormal_retinal_apoptosis | 2.01448053 |
15 | MP0008877_abnormal_DNA_methylation | 2.00719456 |
16 | MP0002653_abnormal_ependyma_morphology | 1.95686627 |
17 | MP0001485_abnormal_pinna_reflex | 1.94398241 |
18 | MP0003806_abnormal_nucleotide_metabolis | 1.88206125 |
19 | MP0008875_abnormal_xenobiotic_pharmacok | 1.86807108 |
20 | MP0001968_abnormal_touch/_nociception | 1.83119493 |
21 | MP0004145_abnormal_muscle_electrophysio | 1.77058484 |
22 | MP0008058_abnormal_DNA_repair | 1.69906836 |
23 | MP0002837_dystrophic_cardiac_calcinosis | 1.66200586 |
24 | MP0000372_irregular_coat_pigmentation | 1.65530469 |
25 | MP0004084_abnormal_cardiac_muscle | 1.63210494 |
26 | MP0008995_early_reproductive_senescence | 1.58651613 |
27 | MP0001905_abnormal_dopamine_level | 1.57899239 |
28 | MP0000749_muscle_degeneration | 1.57839163 |
29 | MP0002160_abnormal_reproductive_system | 1.52828082 |
30 | MP0006276_abnormal_autonomic_nervous | 1.50702058 |
31 | MP0005389_reproductive_system_phenotype | 1.49945665 |
32 | MP0005253_abnormal_eye_physiology | 1.49870243 |
33 | MP0003786_premature_aging | 1.45886974 |
34 | MP0000569_abnormal_digit_pigmentation | 1.44147581 |
35 | MP0003195_calcinosis | 1.41190437 |
36 | MP0008872_abnormal_physiological_respon | 1.41190083 |
37 | MP0001293_anophthalmia | 1.39250452 |
38 | MP0002736_abnormal_nociception_after | 1.38697931 |
39 | MP0005551_abnormal_eye_electrophysiolog | 1.36034367 |
40 | MP0001919_abnormal_reproductive_system | 1.34400067 |
41 | MP0004142_abnormal_muscle_tone | 1.31283362 |
42 | MP0001984_abnormal_olfaction | 1.29757200 |
43 | MP0001764_abnormal_homeostasis | 1.27438332 |
44 | MP0002751_abnormal_autonomic_nervous | 1.27104001 |
45 | MP0010386_abnormal_urinary_bladder | 1.25159587 |
46 | MP0003121_genomic_imprinting | 1.24951239 |
47 | MP0003880_abnormal_central_pattern | 1.23917354 |
48 | MP0001486_abnormal_startle_reflex | 1.23550112 |
49 | MP0002163_abnormal_gland_morphology | 1.23092863 |
50 | MP0002272_abnormal_nervous_system | 1.18813148 |
51 | MP0003718_maternal_effect | 1.17926625 |
52 | MP0008775_abnormal_heart_ventricle | 1.15816143 |
53 | MP0005075_abnormal_melanosome_morpholog | 1.12353432 |
54 | MP0001270_distended_abdomen | 1.11831334 |
55 | MP0009046_muscle_twitch | 1.09852597 |
56 | MP0004215_abnormal_myocardial_fiber | 1.08856694 |
57 | MP0002638_abnormal_pupillary_reflex | 1.03686912 |
58 | MP0002735_abnormal_chemical_nociception | 1.01568140 |
59 | MP0002822_catalepsy | 0.97823564 |
60 | MP0002733_abnormal_thermal_nociception | 0.95950907 |
61 | MP0000631_abnormal_neuroendocrine_gland | 0.94272249 |
62 | MP0005671_abnormal_response_to | 0.92774058 |
63 | MP0002876_abnormal_thyroid_physiology | 0.92593850 |
64 | MP0000647_abnormal_sebaceous_gland | 0.92389752 |
65 | MP0005195_abnormal_posterior_eye | 0.92347451 |
66 | MP0003693_abnormal_embryo_hatching | 0.89888320 |
67 | MP0002090_abnormal_vision | 0.89325622 |
68 | MP0005187_abnormal_penis_morphology | 0.88385579 |
69 | MP0005408_hypopigmentation | 0.87669716 |
70 | MP0009745_abnormal_behavioral_response | 0.87074403 |
71 | MP0000427_abnormal_hair_cycle | 0.84045079 |
72 | MP0002928_abnormal_bile_duct | 0.83038811 |
73 | MP0005220_abnormal_exocrine_pancreas | 0.82969718 |
74 | MP0001970_abnormal_pain_threshold | 0.81384598 |
75 | MP0002277_abnormal_respiratory_mucosa | 0.79878830 |
76 | MP0000685_abnormal_immune_system | 0.79876267 |
77 | MP0005386_behavior/neurological_phenoty | 0.79708854 |
78 | MP0004924_abnormal_behavior | 0.79708854 |
79 | MP0002752_abnormal_somatic_nervous | 0.78496610 |
80 | MP0003186_abnormal_redox_activity | 0.74948297 |
81 | MP0004147_increased_porphyrin_level | 0.74008120 |
82 | MP0002557_abnormal_social/conspecific_i | 0.73671079 |
83 | MP0002938_white_spotting | 0.72823644 |
84 | MP0005330_cardiomyopathy | 0.72808363 |
85 | MP0005360_urolithiasis | 0.72743330 |
86 | MP0000049_abnormal_middle_ear | 0.72742975 |
87 | MP0001986_abnormal_taste_sensitivity | 0.72434637 |
88 | MP0005391_vision/eye_phenotype | 0.71475882 |
89 | MP0009785_altered_susceptibility_to | 0.70883831 |
90 | MP0000026_abnormal_inner_ear | 0.70799540 |
91 | MP0002067_abnormal_sensory_capabilities | 0.70791851 |
92 | MP0008007_abnormal_cellular_replicative | 0.70768221 |
93 | MP0000778_abnormal_nervous_system | 0.70468937 |
94 | MP0009697_abnormal_copulation | 0.70444422 |
95 | MP0003011_delayed_dark_adaptation | 0.68977180 |
96 | MP0002734_abnormal_mechanical_nocicepti | 0.68949047 |
97 | MP0002572_abnormal_emotion/affect_behav | 0.68596283 |
98 | MP0002095_abnormal_skin_pigmentation | 0.67475337 |
99 | MP0005332_abnormal_amino_acid | 0.67021906 |
100 | MP0001440_abnormal_grooming_behavior | 0.66567404 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Renal cortical cysts (HP:0000803) | 4.42519493 |
2 | Calf muscle hypertrophy (HP:0008981) | 4.09352636 |
3 | Acute necrotizing encephalopathy (HP:0006965) | 3.77712023 |
4 | Abolished electroretinogram (ERG) (HP:0000550) | 3.69024817 |
5 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.59499514 |
6 | Exercise-induced muscle cramps (HP:0003710) | 3.51344746 |
7 | Mitochondrial inheritance (HP:0001427) | 3.40379566 |
8 | Hepatocellular necrosis (HP:0001404) | 3.32308545 |
9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.30388145 |
10 | Increased CSF lactate (HP:0002490) | 3.29401145 |
11 | Progressive macrocephaly (HP:0004481) | 3.27075817 |
12 | Medial flaring of the eyebrow (HP:0010747) | 3.26638759 |
13 | Acute encephalopathy (HP:0006846) | 3.22660135 |
14 | Hepatic necrosis (HP:0002605) | 3.21837281 |
15 | Abnormality of the renal cortex (HP:0011035) | 3.17614013 |
16 | Abnormal protein glycosylation (HP:0012346) | 3.15832670 |
17 | Abnormal glycosylation (HP:0012345) | 3.15832670 |
18 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.15832670 |
19 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.15832670 |
20 | Hyperglycinemia (HP:0002154) | 3.10786998 |
21 | Retinal dysplasia (HP:0007973) | 3.07860068 |
22 | Type I transferrin isoform profile (HP:0003642) | 3.03838915 |
23 | Tubulointerstitial nephritis (HP:0001970) | 3.03385782 |
24 | Type II lissencephaly (HP:0007260) | 3.01381514 |
25 | Inability to walk (HP:0002540) | 2.93598802 |
26 | Molar tooth sign on MRI (HP:0002419) | 2.90504979 |
27 | Abnormality of midbrain morphology (HP:0002418) | 2.90504979 |
28 | Brushfield spots (HP:0001088) | 2.84098484 |
29 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.69325586 |
30 | Constricted visual fields (HP:0001133) | 2.65168275 |
31 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.61938567 |
32 | Pancreatic fibrosis (HP:0100732) | 2.59350637 |
33 | Increased serum pyruvate (HP:0003542) | 2.57337201 |
34 | Cerebral edema (HP:0002181) | 2.55211259 |
35 | Myotonia (HP:0002486) | 2.52881103 |
36 | Amelogenesis imperfecta (HP:0000705) | 2.51531161 |
37 | Pancreatic cysts (HP:0001737) | 2.50294352 |
38 | Increased serum lactate (HP:0002151) | 2.50004709 |
39 | Congenital, generalized hypertrichosis (HP:0004540) | 2.44822064 |
40 | Abnormality of the labia minora (HP:0012880) | 2.43235629 |
41 | True hermaphroditism (HP:0010459) | 2.42903760 |
42 | 3-Methylglutaconic aciduria (HP:0003535) | 2.42428111 |
43 | Pachygyria (HP:0001302) | 2.41806033 |
44 | Nephronophthisis (HP:0000090) | 2.37471916 |
45 | Aplastic anemia (HP:0001915) | 2.36032463 |
46 | Abnormality of alanine metabolism (HP:0010916) | 2.34849497 |
47 | Hyperalaninemia (HP:0003348) | 2.34849497 |
48 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.34849497 |
49 | Optic disc pallor (HP:0000543) | 2.33717775 |
50 | Increased corneal curvature (HP:0100692) | 2.30391241 |
51 | Keratoconus (HP:0000563) | 2.30391241 |
52 | Lissencephaly (HP:0001339) | 2.25787281 |
53 | Increased hepatocellular lipid droplets (HP:0006565) | 2.24685715 |
54 | Lactic acidosis (HP:0003128) | 2.24267268 |
55 | Subaortic stenosis (HP:0001682) | 2.24225674 |
56 | Abnormality of the left ventricular outflow tract (HP:0011103) | 2.24225674 |
57 | Lipid accumulation in hepatocytes (HP:0006561) | 2.23344487 |
58 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.23094140 |
59 | Tubular atrophy (HP:0000092) | 2.17750382 |
60 | Poor suck (HP:0002033) | 2.16992300 |
61 | Methylmalonic acidemia (HP:0002912) | 2.13444449 |
62 | Attenuation of retinal blood vessels (HP:0007843) | 2.12387815 |
63 | Congenital stationary night blindness (HP:0007642) | 2.11863492 |
64 | Lethargy (HP:0001254) | 2.11058249 |
65 | Abnormality of glycolysis (HP:0004366) | 2.10117680 |
66 | Congenital primary aphakia (HP:0007707) | 2.08565890 |
67 | Hyperglycinuria (HP:0003108) | 2.07519334 |
68 | Gait imbalance (HP:0002141) | 2.05701196 |
69 | Respiratory failure (HP:0002878) | 2.01539735 |
70 | Hypoplasia of the thymus (HP:0000778) | 2.00815704 |
71 | Exercise-induced myalgia (HP:0003738) | 1.99824123 |
72 | Optic nerve hypoplasia (HP:0000609) | 1.96960460 |
73 | Thyroid-stimulating hormone excess (HP:0002925) | 1.95535843 |
74 | Abnormality of the renal medulla (HP:0100957) | 1.94012786 |
75 | CNS demyelination (HP:0007305) | 1.93528462 |
76 | Nephrogenic diabetes insipidus (HP:0009806) | 1.91726012 |
77 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.91671200 |
78 | Abnormality of glycine metabolism (HP:0010895) | 1.91671200 |
79 | Abnormality of macular pigmentation (HP:0008002) | 1.90735033 |
80 | Prostate neoplasm (HP:0100787) | 1.88755174 |
81 | Polydipsia (HP:0001959) | 1.88024643 |
82 | Abnormal drinking behavior (HP:0030082) | 1.88024643 |
83 | Sudden death (HP:0001699) | 1.85188233 |
84 | Type 2 muscle fiber atrophy (HP:0003554) | 1.83588701 |
85 | Abnormality of serum amino acid levels (HP:0003112) | 1.82561166 |
86 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.82548502 |
87 | Sclerocornea (HP:0000647) | 1.82305243 |
88 | Cerebral hypomyelination (HP:0006808) | 1.78681324 |
89 | Hypothermia (HP:0002045) | 1.78505054 |
90 | Neoplasm of the adrenal cortex (HP:0100641) | 1.78128362 |
91 | Redundant skin (HP:0001582) | 1.78077293 |
92 | Palpebral edema (HP:0100540) | 1.77639045 |
93 | Methylmalonic aciduria (HP:0012120) | 1.77355943 |
94 | Amyotrophic lateral sclerosis (HP:0007354) | 1.75579809 |
95 | Hypoproteinemia (HP:0003075) | 1.75425471 |
96 | Dry hair (HP:0011359) | 1.74591339 |
97 | Generalized aminoaciduria (HP:0002909) | 1.73209937 |
98 | Metaphyseal dysplasia (HP:0100255) | 1.72025442 |
99 | Barrel-shaped chest (HP:0001552) | 1.71688433 |
100 | Cerebellar dysplasia (HP:0007033) | 1.67886852 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BMPR1B | 3.63624642 |
2 | CDK8 | 3.27405512 |
3 | EIF2AK3 | 3.23104134 |
4 | ZAK | 3.20275611 |
5 | MAPKAPK5 | 3.06348050 |
6 | MAP4K2 | 3.05246061 |
7 | TLK1 | 2.65661121 |
8 | VRK2 | 2.54253800 |
9 | BCKDK | 2.38582996 |
10 | FRK | 2.25437749 |
11 | VRK1 | 2.25083603 |
12 | CCNB1 | 2.14549270 |
13 | ADRBK2 | 2.11900848 |
14 | WNK3 | 1.99559398 |
15 | STK16 | 1.99208361 |
16 | PINK1 | 1.70350479 |
17 | TXK | 1.67185890 |
18 | BCR | 1.59918735 |
19 | MUSK | 1.58383491 |
20 | DYRK2 | 1.47186917 |
21 | MAP2K7 | 1.45917914 |
22 | GRK1 | 1.43922251 |
23 | WNK4 | 1.40204942 |
24 | TGFBR1 | 1.36920665 |
25 | TAF1 | 1.32734125 |
26 | OXSR1 | 1.31744028 |
27 | TSSK6 | 1.17802095 |
28 | SCYL2 | 1.17437370 |
29 | PLK3 | 1.15905156 |
30 | MST4 | 1.15300915 |
31 | CDK9 | 1.15228311 |
32 | STK39 | 1.12690553 |
33 | MAP3K4 | 1.11560897 |
34 | MKNK1 | 1.11201151 |
35 | NUAK1 | 1.08357536 |
36 | SRPK1 | 1.06479594 |
37 | PLK2 | 1.06196189 |
38 | CDK19 | 1.04887477 |
39 | PIM2 | 1.01361756 |
40 | EIF2AK1 | 1.00097761 |
41 | NEK1 | 0.99887333 |
42 | CSNK1G3 | 0.97449886 |
43 | CSNK1G2 | 0.96415889 |
44 | DYRK3 | 0.92618726 |
45 | MAPKAPK3 | 0.90492430 |
46 | TRIM28 | 0.89956620 |
47 | TAOK3 | 0.88973270 |
48 | KIT | 0.88331964 |
49 | RPS6KA4 | 0.86494568 |
50 | RPS6KA5 | 0.84263737 |
51 | FLT3 | 0.83633809 |
52 | PLK4 | 0.74548206 |
53 | NTRK2 | 0.72679304 |
54 | PAK6 | 0.72512554 |
55 | MAP3K7 | 0.68029245 |
56 | PRKCG | 0.67583921 |
57 | PRKCE | 0.67261384 |
58 | CSNK1A1L | 0.66990524 |
59 | LIMK1 | 0.66524513 |
60 | CSNK1G1 | 0.65561142 |
61 | TIE1 | 0.63723658 |
62 | BUB1 | 0.59984369 |
63 | PLK1 | 0.59633803 |
64 | TEC | 0.59564724 |
65 | ERBB3 | 0.59504957 |
66 | SIK3 | 0.54868536 |
67 | KDR | 0.53513618 |
68 | AURKB | 0.52820648 |
69 | PHKG1 | 0.52168351 |
70 | PHKG2 | 0.52168351 |
71 | MKNK2 | 0.51028216 |
72 | DAPK3 | 0.49915612 |
73 | INSRR | 0.49537496 |
74 | DAPK1 | 0.49411575 |
75 | PRKACB | 0.49231229 |
76 | CASK | 0.48942789 |
77 | CSNK1A1 | 0.47450586 |
78 | ATR | 0.44393734 |
79 | AURKA | 0.44291406 |
80 | AKT3 | 0.42393042 |
81 | CSNK2A1 | 0.41505345 |
82 | DYRK1B | 0.40829395 |
83 | PKN1 | 0.40723201 |
84 | MARK1 | 0.40516719 |
85 | CAMK2A | 0.40162712 |
86 | CSNK1D | 0.39905645 |
87 | CAMK2D | 0.39790611 |
88 | CSNK2A2 | 0.39717424 |
89 | PRKCQ | 0.38411196 |
90 | DAPK2 | 0.37710260 |
91 | EIF2AK2 | 0.33163478 |
92 | EPHA3 | 0.32596930 |
93 | ADRBK1 | 0.31488529 |
94 | IGF1R | 0.31433896 |
95 | SYK | 0.31300338 |
96 | PRKACA | 0.29772581 |
97 | AKT2 | 0.29627375 |
98 | MAPK7 | 0.28775067 |
99 | OBSCN | 0.28203326 |
100 | MAPK13 | 0.28120645 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 3.75829260 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.30393048 |
3 | Protein export_Homo sapiens_hsa03060 | 3.10371042 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.85581716 |
5 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.73873416 |
6 | RNA polymerase_Homo sapiens_hsa03020 | 2.39862265 |
7 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.35066975 |
8 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 2.15877718 |
9 | Selenocompound metabolism_Homo sapiens_hsa00450 | 2.10311952 |
10 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.03961135 |
11 | RNA degradation_Homo sapiens_hsa03018 | 1.94800268 |
12 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.82240531 |
13 | Huntingtons disease_Homo sapiens_hsa05016 | 1.78299607 |
14 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.75012138 |
15 | Alzheimers disease_Homo sapiens_hsa05010 | 1.70900240 |
16 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.68661781 |
17 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.65920795 |
18 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.64211517 |
19 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.61821170 |
20 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.60815696 |
21 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.56879309 |
22 | Basal transcription factors_Homo sapiens_hsa03022 | 1.53764169 |
23 | Spliceosome_Homo sapiens_hsa03040 | 1.52816901 |
24 | Ribosome_Homo sapiens_hsa03010 | 1.51940083 |
25 | Peroxisome_Homo sapiens_hsa04146 | 1.51793808 |
26 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.49781271 |
27 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.42553670 |
28 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.41342661 |
29 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.39692040 |
30 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.39061154 |
31 | Base excision repair_Homo sapiens_hsa03410 | 1.38574354 |
32 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.36842914 |
33 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.32757236 |
34 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.31510002 |
35 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.28661488 |
36 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.28564911 |
37 | Phototransduction_Homo sapiens_hsa04744 | 1.23966008 |
38 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.22440450 |
39 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.19592981 |
40 | Mismatch repair_Homo sapiens_hsa03430 | 1.17624700 |
41 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.15103888 |
42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.14647175 |
43 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.14140212 |
44 | Homologous recombination_Homo sapiens_hsa03440 | 1.14102627 |
45 | RNA transport_Homo sapiens_hsa03013 | 1.13128268 |
46 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.11105824 |
47 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.08248656 |
48 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.06573719 |
49 | Asthma_Homo sapiens_hsa05310 | 1.06321004 |
50 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.06280809 |
51 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.05735237 |
52 | Purine metabolism_Homo sapiens_hsa00230 | 1.04848193 |
53 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.98226974 |
54 | Sulfur relay system_Homo sapiens_hsa04122 | 0.96694100 |
55 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.96117651 |
56 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.94422730 |
57 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.90845057 |
58 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.88559652 |
59 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.88517276 |
60 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.86710174 |
61 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.85242077 |
62 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.85029207 |
63 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.84925275 |
64 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.79384619 |
65 | DNA replication_Homo sapiens_hsa03030 | 0.76087887 |
66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.74431065 |
67 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.72843751 |
68 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.67849660 |
69 | Nicotine addiction_Homo sapiens_hsa05033 | 0.67306120 |
70 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.63689775 |
71 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.63574824 |
72 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.63010762 |
73 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.62781157 |
74 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.61982493 |
75 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.61640265 |
76 | Olfactory transduction_Homo sapiens_hsa04740 | 0.61623936 |
77 | Alcoholism_Homo sapiens_hsa05034 | 0.57652829 |
78 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.56479443 |
79 | Allograft rejection_Homo sapiens_hsa05330 | 0.52125401 |
80 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.49199860 |
81 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.49089126 |
82 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.48949848 |
83 | Carbon metabolism_Homo sapiens_hsa01200 | 0.47540609 |
84 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.45459618 |
85 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.44332139 |
86 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.42656169 |
87 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.42297240 |
88 | Histidine metabolism_Homo sapiens_hsa00340 | 0.40959175 |
89 | Retinol metabolism_Homo sapiens_hsa00830 | 0.40876615 |
90 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.40616362 |
91 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.38855323 |
92 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.36871425 |
93 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.35082000 |
94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.34462203 |
95 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.33629741 |
96 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.31003697 |
97 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.28533376 |
98 | GABAergic synapse_Homo sapiens_hsa04727 | 0.28506984 |
99 | Morphine addiction_Homo sapiens_hsa05032 | 0.28238153 |
100 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.27324530 |