ST13P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.02393433
2DNA deamination (GO:0045006)4.71541302
3organelle disassembly (GO:1903008)4.65539583
4pattern specification involved in kidney development (GO:0061004)4.31812779
5chaperone-mediated protein transport (GO:0072321)4.26299303
6ribonucleoprotein complex disassembly (GO:0032988)4.21689912
7regulation of action potential (GO:0098900)4.21318211
8regulation of sarcomere organization (GO:0060297)3.96423804
9synaptic transmission, cholinergic (GO:0007271)3.82385061
10ubiquinone biosynthetic process (GO:0006744)3.74771586
11nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72576269
12ribosomal small subunit assembly (GO:0000028)3.66514551
13detection of light stimulus involved in visual perception (GO:0050908)3.65316183
14detection of light stimulus involved in sensory perception (GO:0050962)3.65316183
15protein neddylation (GO:0045116)3.62225529
16viral transcription (GO:0019083)3.61729259
17water-soluble vitamin biosynthetic process (GO:0042364)3.61425738
18negative regulation of organelle assembly (GO:1902116)3.59192202
19translational elongation (GO:0006414)3.55468834
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.52688434
21NADH dehydrogenase complex assembly (GO:0010257)3.52688434
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52688434
23regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.52670852
24translational termination (GO:0006415)3.52286213
25negative regulation of transcription regulatory region DNA binding (GO:2000678)3.52243973
26regulation of skeletal muscle contraction (GO:0014819)3.51820206
27neural tube formation (GO:0001841)3.51561975
28endoderm formation (GO:0001706)3.50227825
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47922881
30ubiquinone metabolic process (GO:0006743)3.47326587
31response to pheromone (GO:0019236)3.43706592
32cornea development in camera-type eye (GO:0061303)3.42755187
33maturation of SSU-rRNA (GO:0030490)3.42536039
34ribosomal large subunit biogenesis (GO:0042273)3.38028785
35platelet dense granule organization (GO:0060155)3.36946383
36pyrimidine nucleobase catabolic process (GO:0006208)3.32621085
37protein complex biogenesis (GO:0070271)3.32526778
38protein-cofactor linkage (GO:0018065)3.28756614
39cell fate commitment involved in formation of primary germ layer (GO:0060795)3.26092051
40regulation of hippo signaling (GO:0035330)3.25765627
41spinal cord development (GO:0021510)3.17630794
42somite development (GO:0061053)3.11439526
43substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.10776175
44substrate-independent telencephalic tangential migration (GO:0021826)3.10776175
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07263205
46base-excision repair, AP site formation (GO:0006285)3.03450925
47negative regulation of nitric-oxide synthase activity (GO:0051001)3.03256699
48cytidine metabolic process (GO:0046087)3.02407565
49cytidine catabolic process (GO:0006216)3.02407565
50cytidine deamination (GO:0009972)3.02407565
51negative regulation of mast cell activation (GO:0033004)2.99972026
52protein polyglutamylation (GO:0018095)2.98774401
53cotranslational protein targeting to membrane (GO:0006613)2.97335995
54transcription elongation from RNA polymerase III promoter (GO:0006385)2.95825368
55termination of RNA polymerase III transcription (GO:0006386)2.95825368
56quinone biosynthetic process (GO:1901663)2.94089299
57viral life cycle (GO:0019058)2.93305311
58protein targeting to ER (GO:0045047)2.91038229
59tongue development (GO:0043586)2.90186923
60SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90104222
61protein localization to endoplasmic reticulum (GO:0070972)2.85425129
62transmission of nerve impulse (GO:0019226)2.84411729
63segment specification (GO:0007379)2.83012907
64mitochondrial respiratory chain complex assembly (GO:0033108)2.82962552
65olfactory bulb development (GO:0021772)2.80978288
66regulation of cilium movement (GO:0003352)2.80166411
67establishment of protein localization to mitochondrial membrane (GO:0090151)2.79490524
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.77975630
69tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.77975630
70DNA demethylation (GO:0080111)2.77217419
71negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.76491474
72negative regulation of protein localization to cell surface (GO:2000009)2.76261962
73interferon-gamma production (GO:0032609)2.74233547
74establishment of protein localization to endoplasmic reticulum (GO:0072599)2.74055484
75ATP synthesis coupled proton transport (GO:0015986)2.73542107
76energy coupled proton transport, down electrochemical gradient (GO:0015985)2.73542107
77ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.72522182
78intraciliary transport (GO:0042073)2.71917353
79L-fucose catabolic process (GO:0042355)2.71914048
80fucose catabolic process (GO:0019317)2.71914048
81L-fucose metabolic process (GO:0042354)2.71914048
82nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71339221
83nonmotile primary cilium assembly (GO:0035058)2.70187737
84nucleobase catabolic process (GO:0046113)2.67775059
85chaperone mediated protein folding requiring cofactor (GO:0051085)2.66293600
86RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.65658560
87dentate gyrus development (GO:0021542)2.65651907
88indole-containing compound catabolic process (GO:0042436)2.64734873
89indolalkylamine catabolic process (GO:0046218)2.64734873
90tryptophan catabolic process (GO:0006569)2.64734873
91negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.64242019
92pyrimidine ribonucleoside catabolic process (GO:0046133)2.63436892
93spliceosomal complex assembly (GO:0000245)2.63117373
94translation (GO:0006412)2.62359935
95negative regulation of appetite (GO:0032099)2.59557991
96negative regulation of response to food (GO:0032096)2.59557991
97positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.57400252
98regulation of cellular respiration (GO:0043457)2.56018387
99kynurenine metabolic process (GO:0070189)2.55956123
100detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54727549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34393832
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.71560836
3VDR_22108803_ChIP-Seq_LS180_Human3.22207114
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.13758893
5ZNF274_21170338_ChIP-Seq_K562_Hela3.10504697
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.92879382
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75396757
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.49524382
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.47342724
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16951657
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16639996
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.01560539
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.00930585
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95610502
15GBX2_23144817_ChIP-Seq_PC3_Human1.94852304
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94458788
17RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81312304
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77866107
19IRF1_19129219_ChIP-ChIP_H3396_Human1.77181088
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75594945
21VDR_23849224_ChIP-Seq_CD4+_Human1.70998904
22IGF1R_20145208_ChIP-Seq_DFB_Human1.69919544
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63564239
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.61471624
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59282324
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.58083936
27EWS_26573619_Chip-Seq_HEK293_Human1.57874817
28TP53_22573176_ChIP-Seq_HFKS_Human1.56425308
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53089983
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52757170
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.51688367
32FOXP3_21729870_ChIP-Seq_TREG_Human1.45039447
33NANOG_20526341_ChIP-Seq_ESCs_Human1.39260285
34REST_21632747_ChIP-Seq_MESCs_Mouse1.39250638
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38899037
36CBP_20019798_ChIP-Seq_JUKART_Human1.38899037
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38891607
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38580162
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37761921
40MYC_18940864_ChIP-ChIP_HL60_Human1.37602850
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32601655
42ELK1_19687146_ChIP-ChIP_HELA_Human1.31959535
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30055661
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28641715
45P300_19829295_ChIP-Seq_ESCs_Human1.28317811
46STAT1_20625510_ChIP-Seq_HELA_Human1.26960174
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24407404
48CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.23309332
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.22432544
50AR_20517297_ChIP-Seq_VCAP_Human1.22396410
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22367741
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20360451
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.19161970
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18935302
55NCOR_22424771_ChIP-Seq_293T_Human1.15141242
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15067699
57RNF2_27304074_Chip-Seq_NSC_Mouse1.13637361
58BCAT_22108803_ChIP-Seq_LS180_Human1.12396365
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10793225
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.10645923
61EZH2_27294783_Chip-Seq_ESCs_Mouse1.10348449
62GABP_19822575_ChIP-Seq_HepG2_Human1.09791940
63CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09265457
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.08396175
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08354413
66ERA_21632823_ChIP-Seq_H3396_Human1.08261823
67MYC_19829295_ChIP-Seq_ESCs_Human1.05075291
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05056475
69CIITA_25753668_ChIP-Seq_RAJI_Human1.03680429
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02443637
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02403963
72YY1_22570637_ChIP-Seq_MALME-3M_Human1.01983513
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00813540
74NANOG_19829295_ChIP-Seq_ESCs_Human0.99219936
75SOX2_19829295_ChIP-Seq_ESCs_Human0.99219936
76P53_22387025_ChIP-Seq_ESCs_Mouse0.98556735
77EZH2_27294783_Chip-Seq_NPCs_Mouse0.98398318
78TTF2_22483619_ChIP-Seq_HELA_Human0.97618104
79WDR5_24793694_ChIP-Seq_LNCAP_Human0.97352890
80STAT3_18555785_Chip-Seq_ESCs_Mouse0.96225447
81CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96158750
82HOXB7_26014856_ChIP-Seq_BT474_Human0.95392697
83TAF2_19829295_ChIP-Seq_ESCs_Human0.94690039
84TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94601738
85REST_18959480_ChIP-ChIP_MESCs_Mouse0.93315085
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92988902
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92557989
88SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90406480
89PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90240514
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.89930374
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88087948
92POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88087948
93P53_21459846_ChIP-Seq_SAOS-2_Human0.87515845
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86921300
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.86867580
96ER_23166858_ChIP-Seq_MCF-7_Human0.86737694
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85990302
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85752479
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.85019764
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85019764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.49870043
2MP0003787_abnormal_imprinting3.34900269
3MP0006072_abnormal_retinal_apoptosis3.33537288
4MP0008877_abnormal_DNA_methylation3.28777398
5MP0005645_abnormal_hypothalamus_physiol2.76038335
6MP0008789_abnormal_olfactory_epithelium2.54850093
7MP0008872_abnormal_physiological_respon2.53184521
8MP0006292_abnormal_olfactory_placode2.47468358
9MP0004142_abnormal_muscle_tone2.44337580
10MP0001529_abnormal_vocalization2.03741887
11MP0002653_abnormal_ependyma_morphology2.03738882
12MP0005394_taste/olfaction_phenotype1.93935189
13MP0005499_abnormal_olfactory_system1.93935189
14MP0005646_abnormal_pituitary_gland1.93297459
15MP0003195_calcinosis1.85975824
16MP0001485_abnormal_pinna_reflex1.85074095
17MP0005551_abnormal_eye_electrophysiolog1.84441215
18MP0001905_abnormal_dopamine_level1.84021879
19MP0002272_abnormal_nervous_system1.76373068
20MP0002163_abnormal_gland_morphology1.67180934
21MP0009745_abnormal_behavioral_response1.64629719
22MP0000778_abnormal_nervous_system1.60101048
23MP0008995_early_reproductive_senescence1.59631255
24MP0003121_genomic_imprinting1.59367035
25MP0005253_abnormal_eye_physiology1.58093006
26MP0002733_abnormal_thermal_nociception1.51660894
27MP0004145_abnormal_muscle_electrophysio1.51184836
28MP0002837_dystrophic_cardiac_calcinosis1.49399830
29MP0005423_abnormal_somatic_nervous1.46667901
30MP0003646_muscle_fatigue1.46600897
31MP0009046_muscle_twitch1.43080472
32MP0000427_abnormal_hair_cycle1.42338656
33MP0005389_reproductive_system_phenotype1.40497863
34MP0002160_abnormal_reproductive_system1.38974143
35MP0001919_abnormal_reproductive_system1.38931420
36MP0001486_abnormal_startle_reflex1.36489203
37MP0001970_abnormal_pain_threshold1.36465956
38MP0001968_abnormal_touch/_nociception1.36225381
39MP0003880_abnormal_central_pattern1.36030667
40MP0006276_abnormal_autonomic_nervous1.35580528
41MP0004924_abnormal_behavior1.32269367
42MP0005386_behavior/neurological_phenoty1.32269367
43MP0009764_decreased_sensitivity_to1.29798790
44MP0002557_abnormal_social/conspecific_i1.28968640
45MP0000049_abnormal_middle_ear1.28288868
46MP0004885_abnormal_endolymph1.27950389
47MP0003283_abnormal_digestive_organ1.25271657
48MP0003122_maternal_imprinting1.25199655
49MP0002938_white_spotting1.23179342
50MP0002572_abnormal_emotion/affect_behav1.19168180
51MP0008875_abnormal_xenobiotic_pharmacok1.18574177
52MP0000631_abnormal_neuroendocrine_gland1.18334002
53MP0003950_abnormal_plasma_membrane1.18033525
54MP0009379_abnormal_foot_pigmentation1.16838649
55MP0001986_abnormal_taste_sensitivity1.15320973
56MP0003635_abnormal_synaptic_transmissio1.12999315
57MP0001293_anophthalmia1.11919703
58MP0003879_abnormal_hair_cell1.09747349
59MP0002063_abnormal_learning/memory/cond1.07367645
60MP0005195_abnormal_posterior_eye1.05573250
61MP0005671_abnormal_response_to1.05310919
62MP0001440_abnormal_grooming_behavior1.00230444
63MP0000613_abnormal_salivary_gland0.98551436
64MP0005379_endocrine/exocrine_gland_phen0.98256966
65MP0001727_abnormal_embryo_implantation0.97795356
66MP0002184_abnormal_innervation0.95827621
67MP0002752_abnormal_somatic_nervous0.95351806
68MP0008058_abnormal_DNA_repair0.94474632
69MP0004742_abnormal_vestibular_system0.94272958
70MP0003186_abnormal_redox_activity0.93869004
71MP0002736_abnormal_nociception_after0.93845688
72MP0004043_abnormal_pH_regulation0.93768762
73MP0001502_abnormal_circadian_rhythm0.93160831
74MP0002735_abnormal_chemical_nociception0.93137338
75MP0002067_abnormal_sensory_capabilities0.90818050
76MP0004147_increased_porphyrin_level0.90165308
77MP0001963_abnormal_hearing_physiology0.87797651
78MP0002064_seizures0.87549279
79MP0001270_distended_abdomen0.86780293
80MP0002734_abnormal_mechanical_nocicepti0.84639671
81MP0001984_abnormal_olfaction0.84299364
82MP0002277_abnormal_respiratory_mucosa0.82471988
83MP0003786_premature_aging0.79531129
84MP0000230_abnormal_systemic_arterial0.79246006
85MP0000026_abnormal_inner_ear0.77478382
86MP0005075_abnormal_melanosome_morpholog0.76228855
87MP0001764_abnormal_homeostasis0.75842918
88MP0003693_abnormal_embryo_hatching0.75557308
89MP0000569_abnormal_digit_pigmentation0.72525101
90MP0002876_abnormal_thyroid_physiology0.72077536
91MP0002638_abnormal_pupillary_reflex0.71771549
92MP0004084_abnormal_cardiac_muscle0.71703888
93MP0009765_abnormal_xenobiotic_induced0.70476288
94MP0003890_abnormal_embryonic-extraembry0.70252138
95MP0002095_abnormal_skin_pigmentation0.67796846
96MP0005647_abnormal_sex_gland0.67525393
97MP0000955_abnormal_spinal_cord0.67515148
98MP0002822_catalepsy0.66705073
99MP0002882_abnormal_neuron_morphology0.65894811
100MP0003718_maternal_effect0.64765885

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)4.24636791
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.24636791
3Absent rod-and cone-mediated responses on ERG (HP:0007688)4.02611560
4Acute necrotizing encephalopathy (HP:0006965)3.67119743
5Tubulointerstitial nephritis (HP:0001970)3.61863278
6Abnormality of the corticospinal tract (HP:0002492)3.53933777
7Type II lissencephaly (HP:0007260)3.37061623
8Acute encephalopathy (HP:0006846)3.25497692
9Pancreatic fibrosis (HP:0100732)3.24113801
10Abnormal mitochondria in muscle tissue (HP:0008316)3.21660572
11Abolished electroretinogram (ERG) (HP:0000550)3.18650911
12Agitation (HP:0000713)3.13527643
13Abnormality of the renal cortex (HP:0011035)3.10182368
14Renal cortical cysts (HP:0000803)3.03887541
15Progressive macrocephaly (HP:0004481)2.99401611
16True hermaphroditism (HP:0010459)2.95797145
17Nephronophthisis (HP:0000090)2.91796177
18Mitochondrial inheritance (HP:0001427)2.90051140
19Hepatocellular necrosis (HP:0001404)2.89015954
20Abnormal rod and cone electroretinograms (HP:0008323)2.84865577
21Aplasia/Hypoplasia of the spleen (HP:0010451)2.80407289
22Abnormality of midbrain morphology (HP:0002418)2.74873322
23Molar tooth sign on MRI (HP:0002419)2.74873322
24Cerebellar dysplasia (HP:0007033)2.74573082
25Calf muscle hypertrophy (HP:0008981)2.72647196
26Lissencephaly (HP:0001339)2.66143787
27Keratoconus (HP:0000563)2.64652131
28Increased corneal curvature (HP:0100692)2.64652131
29Pancreatic cysts (HP:0001737)2.58999218
30Optic disc pallor (HP:0000543)2.57713875
31Increased CSF lactate (HP:0002490)2.55991907
32Asplenia (HP:0001746)2.54086373
33Myotonia (HP:0002486)2.52530867
34Medial flaring of the eyebrow (HP:0010747)2.49013262
35Abnormality of the renal medulla (HP:0100957)2.43284142
36Dry hair (HP:0011359)2.42254791
37Abnormality of the labia minora (HP:0012880)2.41979778
38Cerebral edema (HP:0002181)2.39278485
39Muscle hypertrophy of the lower extremities (HP:0008968)2.34428486
40Attenuation of retinal blood vessels (HP:0007843)2.32034547
41Hepatic necrosis (HP:0002605)2.31032179
42Congenital stationary night blindness (HP:0007642)2.29123552
43Stenosis of the external auditory canal (HP:0000402)2.29037826
44Growth hormone deficiency (HP:0000824)2.28193726
45Increased serum lactate (HP:0002151)2.27633853
463-Methylglutaconic aciduria (HP:0003535)2.26863636
47Abnormality of hair growth rate (HP:0011363)2.20138276
48Slow-growing hair (HP:0002217)2.20138276
49Oligodactyly (hands) (HP:0001180)2.20079887
50Reticulocytopenia (HP:0001896)2.19400486
51Hyperglycinemia (HP:0002154)2.18996306
52Methylmalonic acidemia (HP:0002912)2.17291754
53Abnormal respiratory motile cilium morphology (HP:0005938)2.16321965
54Abnormal respiratory epithelium morphology (HP:0012253)2.16321965
55Congenital, generalized hypertrichosis (HP:0004540)2.16237569
56Intestinal atresia (HP:0011100)2.15887071
57Pendular nystagmus (HP:0012043)2.14620130
58Genetic anticipation (HP:0003743)2.13436233
59Abnormal ciliary motility (HP:0012262)2.13251924
60Pachygyria (HP:0001302)2.10374456
61Constricted visual fields (HP:0001133)2.09759091
62Tubular atrophy (HP:0000092)2.08144977
63Horseshoe kidney (HP:0000085)2.04981013
64Rib fusion (HP:0000902)2.04769953
65Subaortic stenosis (HP:0001682)2.00892259
66Abnormality of the left ventricular outflow tract (HP:0011103)2.00892259
67Elevated erythrocyte sedimentation rate (HP:0003565)2.00313249
68Impaired vibration sensation in the lower limbs (HP:0002166)1.96946254
69Type 2 muscle fiber atrophy (HP:0003554)1.91653092
70Poor suck (HP:0002033)1.90823590
71Morphological abnormality of the pyramidal tract (HP:0002062)1.90684193
72Sclerocornea (HP:0000647)1.88812928
73Abnormal respiratory motile cilium physiology (HP:0012261)1.86003064
74Severe combined immunodeficiency (HP:0004430)1.85757017
75Aplasia/Hypoplasia involving the musculature (HP:0001460)1.81412203
76Methylmalonic aciduria (HP:0012120)1.78726147
77Abnormality of magnesium homeostasis (HP:0004921)1.78680913
78Urinary urgency (HP:0000012)1.78051270
79Adrenal hypoplasia (HP:0000835)1.77366280
80Pigmentary retinal degeneration (HP:0001146)1.75528113
81Inability to walk (HP:0002540)1.73979364
82Dynein arm defect of respiratory motile cilia (HP:0012255)1.73884866
83Absent/shortened dynein arms (HP:0200106)1.73884866
84Lactic acidosis (HP:0003128)1.73457952
85Cystic liver disease (HP:0006706)1.72735507
86Focal seizures (HP:0007359)1.72642239
87Urinary bladder sphincter dysfunction (HP:0002839)1.72431294
88Hypomagnesemia (HP:0002917)1.71691625
89Progressive cerebellar ataxia (HP:0002073)1.70904589
90Male pseudohermaphroditism (HP:0000037)1.70698648
91Tubulointerstitial abnormality (HP:0001969)1.70638045
92Abnormal drinking behavior (HP:0030082)1.70546940
93Polydipsia (HP:0001959)1.70546940
94Retinal dysplasia (HP:0007973)1.68402067
95Lethargy (HP:0001254)1.68063715
96Mesangial abnormality (HP:0001966)1.67619907
97Chronic hepatic failure (HP:0100626)1.67418191
98Exercise-induced myalgia (HP:0003738)1.67368789
99Vitreoretinal degeneration (HP:0000655)1.67116704
100Septo-optic dysplasia (HP:0100842)1.66730169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.17080046
2MAP4K23.71807445
3WNK43.04698987
4ZAK2.78787777
5WNK32.54986962
6CDK82.50298312
7BMPR1B2.45765321
8CDK192.44003019
9PINK12.24907415
10NUAK12.15400996
11TAOK32.10042680
12ADRBK22.09329499
13MAPKAPK52.05848261
14MUSK1.71460206
15STK391.67867920
16VRK11.60199817
17FRK1.54749246
18CASK1.49842957
19DYRK1B1.44604575
20TLK11.44015076
21OXSR11.37593919
22DYRK21.34080102
23GRK11.32389170
24EIF2AK31.30992711
25TYRO31.29971448
26PIM21.26042131
27MAP3K41.25571320
28KDR1.17807870
29VRK21.16393099
30MAP3K111.09495005
31MAP2K71.07415124
32MAPK131.01854144
33TEC0.99588708
34TXK0.95107507
35TRIM280.93462061
36PKN10.89553738
37EPHB20.86318248
38TIE10.86030720
39ERBB30.85502613
40TNK20.84509224
41PRKCQ0.82391219
42IRAK40.80141352
43PLK40.76497835
44PAK60.76298591
45BCKDK0.72385076
46CAMKK20.68072767
47LRRK20.67594587
48CSNK1G20.67351823
49EIF2AK10.67310528
50PAK30.65212968
51TNIK0.64951630
52CCNB10.62702273
53EPHA40.61986144
54PIM10.59809881
55BMPR20.59619110
56CSNK1G30.58211632
57DAPK30.57809281
58CAMK2D0.57294798
59SYK0.56576091
60TAF10.54307324
61ADRBK10.54218699
62RPS6KA50.52827232
63IKBKB0.52031622
64MAP3K70.51491007
65INSRR0.50670380
66CSNK1D0.50102181
67AURKA0.49713271
68PIK3CG0.48730022
69IKBKE0.48342181
70MST40.47920169
71CHEK20.47578823
72DMPK0.47513573
73EIF2AK20.46614515
74TBK10.44643126
75TGFBR10.44046674
76NTRK20.43181047
77STK38L0.41634382
78PRKCE0.41311828
79CSNK2A20.40881858
80AKT30.40152086
81PRKCH0.40060397
82PHKG20.38743104
83PHKG10.38743104
84PRKACA0.38682398
85PRKCZ0.38212891
86MARK10.38110407
87CSNK1A1L0.37678084
88BTK0.37575884
89GRK60.37075646
90PRKCG0.36775388
91PIK3CA0.36688221
92AURKB0.34870071
93MATK0.34403154
94MOS0.34323433
95PRKCD0.32851060
96KIT0.32306258
97PLK10.31518495
98ITK0.30652521
99ILK0.29219793
100PRKCA0.28993094

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.57645589
2Oxidative phosphorylation_Homo sapiens_hsa001903.43443565
3Parkinsons disease_Homo sapiens_hsa050122.92642010
4Asthma_Homo sapiens_hsa053102.76322129
5RNA polymerase_Homo sapiens_hsa030202.72791241
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.48839502
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.27466171
8Cardiac muscle contraction_Homo sapiens_hsa042602.21308394
9Protein export_Homo sapiens_hsa030602.12428367
10Proteasome_Homo sapiens_hsa030502.08496305
11Allograft rejection_Homo sapiens_hsa053301.98328966
12Caffeine metabolism_Homo sapiens_hsa002321.91708789
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90933894
14Linoleic acid metabolism_Homo sapiens_hsa005911.90869517
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.89420518
16RNA degradation_Homo sapiens_hsa030181.87822798
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86238877
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83271919
19Basal transcription factors_Homo sapiens_hsa030221.81870745
20Huntingtons disease_Homo sapiens_hsa050161.81689567
21Alzheimers disease_Homo sapiens_hsa050101.81347162
22Autoimmune thyroid disease_Homo sapiens_hsa053201.80854389
23Graft-versus-host disease_Homo sapiens_hsa053321.77310597
24Type I diabetes mellitus_Homo sapiens_hsa049401.74283265
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67582741
26Selenocompound metabolism_Homo sapiens_hsa004501.48237127
27Peroxisome_Homo sapiens_hsa041461.46214505
28Collecting duct acid secretion_Homo sapiens_hsa049661.46185407
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43836993
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43363007
31Phototransduction_Homo sapiens_hsa047441.41830800
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41301819
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39014679
34Nicotine addiction_Homo sapiens_hsa050331.36604350
35Primary immunodeficiency_Homo sapiens_hsa053401.36317320
36Tryptophan metabolism_Homo sapiens_hsa003801.34223842
37Systemic lupus erythematosus_Homo sapiens_hsa053221.29356629
38Propanoate metabolism_Homo sapiens_hsa006401.22337250
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21155700
40Rheumatoid arthritis_Homo sapiens_hsa053231.15822146
41Butanoate metabolism_Homo sapiens_hsa006501.12941112
42Viral myocarditis_Homo sapiens_hsa054161.09269983
43Ether lipid metabolism_Homo sapiens_hsa005650.99370418
44Pyrimidine metabolism_Homo sapiens_hsa002400.99322631
45Sulfur metabolism_Homo sapiens_hsa009200.99093066
46beta-Alanine metabolism_Homo sapiens_hsa004100.93184238
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88662274
48Olfactory transduction_Homo sapiens_hsa047400.84900109
49Antigen processing and presentation_Homo sapiens_hsa046120.83715471
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82762312
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82230039
52Chemical carcinogenesis_Homo sapiens_hsa052040.81880538
53Homologous recombination_Homo sapiens_hsa034400.80454203
54Arachidonic acid metabolism_Homo sapiens_hsa005900.79881872
55Glycerolipid metabolism_Homo sapiens_hsa005610.79527371
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77610875
57Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77361022
58Steroid biosynthesis_Homo sapiens_hsa001000.75982487
59Nucleotide excision repair_Homo sapiens_hsa034200.73508857
60Spliceosome_Homo sapiens_hsa030400.73082524
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.73015893
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.71807468
63Fatty acid degradation_Homo sapiens_hsa000710.71187542
64RNA transport_Homo sapiens_hsa030130.70250568
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66525479
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62690236
67Non-homologous end-joining_Homo sapiens_hsa034500.58487944
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58353071
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58141697
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.57739066
71Taste transduction_Homo sapiens_hsa047420.55793442
72Base excision repair_Homo sapiens_hsa034100.55673292
73Metabolic pathways_Homo sapiens_hsa011000.54781624
74Purine metabolism_Homo sapiens_hsa002300.54384959
75Nitrogen metabolism_Homo sapiens_hsa009100.53469727
76Mismatch repair_Homo sapiens_hsa034300.52622061
77Alcoholism_Homo sapiens_hsa050340.52309640
78Fanconi anemia pathway_Homo sapiens_hsa034600.50631990
79Hematopoietic cell lineage_Homo sapiens_hsa046400.48444149
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47596785
81Glutamatergic synapse_Homo sapiens_hsa047240.46990938
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.45738845
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44535806
84Morphine addiction_Homo sapiens_hsa050320.44247378
85Pyruvate metabolism_Homo sapiens_hsa006200.43963763
86Salivary secretion_Homo sapiens_hsa049700.43024356
87Retinol metabolism_Homo sapiens_hsa008300.42713750
88Circadian entrainment_Homo sapiens_hsa047130.42361072
89ABC transporters_Homo sapiens_hsa020100.38946500
90GABAergic synapse_Homo sapiens_hsa047270.38875170
91Ovarian steroidogenesis_Homo sapiens_hsa049130.37398149
92Hedgehog signaling pathway_Homo sapiens_hsa043400.36702718
93Serotonergic synapse_Homo sapiens_hsa047260.33528585
94Staphylococcus aureus infection_Homo sapiens_hsa051500.33468473
95Synaptic vesicle cycle_Homo sapiens_hsa047210.32380155
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30361772
97Dorso-ventral axis formation_Homo sapiens_hsa043200.26696003
98Cholinergic synapse_Homo sapiens_hsa047250.24822136
99Epstein-Barr virus infection_Homo sapiens_hsa051690.24557374
100Oxytocin signaling pathway_Homo sapiens_hsa049210.23108158

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