ST14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.24287425
2interferon-gamma secretion (GO:0072643)6.45676585
3intestinal epithelial cell development (GO:0060576)6.44413681
4bundle of His cell to Purkinje myocyte communication (GO:0086069)6.05836472
5desmosome organization (GO:0002934)5.84225609
6regulation of water loss via skin (GO:0033561)4.86682370
7trophectodermal cell differentiation (GO:0001829)4.50850784
8hepatocyte apoptotic process (GO:0097284)4.47535251
9epithelial cell-cell adhesion (GO:0090136)4.40161498
10intestinal absorption (GO:0050892)4.17013361
11regulation of hippo signaling (GO:0035330)4.11652046
12establishment of skin barrier (GO:0061436)3.99237367
13NADH metabolic process (GO:0006734)3.96212245
14calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.82066313
15maintenance of gastrointestinal epithelium (GO:0030277)3.74142638
16molting cycle (GO:0042303)3.69960618
17hair cycle (GO:0042633)3.69960618
18tight junction assembly (GO:0070830)3.68517378
19UDP-N-acetylglucosamine metabolic process (GO:0006047)3.68499445
20adhesion of symbiont to host cell (GO:0044650)3.62079708
21virion attachment to host cell (GO:0019062)3.62079708
22establishment of apical/basal cell polarity (GO:0035089)3.60318481
23regulation of cholesterol homeostasis (GO:2000188)3.52419785
24multicellular organismal water homeostasis (GO:0050891)3.51138556
25ectoderm development (GO:0007398)3.49757441
26peptidyl-tyrosine autophosphorylation (GO:0038083)3.47137328
27COPI coating of Golgi vesicle (GO:0048205)3.43194962
28Golgi transport vesicle coating (GO:0048200)3.43194962
29epithelial structure maintenance (GO:0010669)3.43125581
30intestinal cholesterol absorption (GO:0030299)3.40084546
31regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.39944657
32negative regulation of keratinocyte proliferation (GO:0010839)3.39032642
33glycosphingolipid catabolic process (GO:0046479)3.34303769
34negative regulation of cell fate specification (GO:0009996)3.30722274
35activation of Rac GTPase activity (GO:0032863)3.28411301
36cell-substrate junction assembly (GO:0007044)3.27821028
37amyloid precursor protein catabolic process (GO:0042987)3.27793139
38glycolipid catabolic process (GO:0019377)3.26357289
39epithelial cell differentiation involved in prostate gland development (GO:0060742)3.26182561
40angiotensin maturation (GO:0002003)3.23477156
41positive regulation of SMAD protein import into nucleus (GO:0060391)3.16325147
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.15649235
43keratinization (GO:0031424)3.15245416
44proline biosynthetic process (GO:0006561)3.15114652
45polarized epithelial cell differentiation (GO:0030859)3.14135756
46primary alcohol catabolic process (GO:0034310)3.13159080
47O-glycan processing (GO:0016266)3.11247920
48negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.10725965
49regulation of posttranscriptional gene silencing (GO:0060147)3.10632963
50regulation of gene silencing by miRNA (GO:0060964)3.10632963
51regulation of gene silencing by RNA (GO:0060966)3.10632963
52vitamin transmembrane transport (GO:0035461)3.10211953
53regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.09203961
54phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.07989683
55renal system process involved in regulation of blood volume (GO:0001977)3.07713235
56branching involved in mammary gland duct morphogenesis (GO:0060444)3.05818280
57ethanol metabolic process (GO:0006067)3.05523699
58urea cycle (GO:0000050)3.05511305
59vitamin A metabolic process (GO:0006776)3.03933410
60hypotonic response (GO:0006971)3.03276226
61adhesion of symbiont to host (GO:0044406)3.01906175
62cell differentiation involved in embryonic placenta development (GO:0060706)3.01430187
63sphingomyelin metabolic process (GO:0006684)3.00568581
64regulation of guanylate cyclase activity (GO:0031282)2.99015507
65GDP-mannose metabolic process (GO:0019673)2.96882546
66apoptotic process involved in morphogenesis (GO:0060561)2.96674400
67peptide catabolic process (GO:0043171)2.96288347
68epoxygenase P450 pathway (GO:0019373)2.95642992
69amyloid precursor protein metabolic process (GO:0042982)2.93215164
70branching involved in labyrinthine layer morphogenesis (GO:0060670)2.90808216
71positive regulation of epidermal cell differentiation (GO:0045606)2.90445348
72positive regulation of glycoprotein metabolic process (GO:1903020)2.89023243
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.88883655
74columnar/cuboidal epithelial cell development (GO:0002066)2.88819467
75positive regulation of Cdc42 GTPase activity (GO:0043089)2.88542085
76negative regulation of cell fate commitment (GO:0010454)2.86751317
77establishment or maintenance of monopolar cell polarity (GO:0061339)2.86097334
78establishment of monopolar cell polarity (GO:0061162)2.86097334
79regulation of vitamin metabolic process (GO:0030656)2.85802631
80anterior/posterior axis specification, embryo (GO:0008595)2.85321288
81glutathione biosynthetic process (GO:0006750)2.83402429
82positive regulation of keratinocyte differentiation (GO:0045618)2.81299174
83renal filtration (GO:0097205)2.80384005
84water homeostasis (GO:0030104)2.78681050
85urea metabolic process (GO:0019627)2.78578527
86fat-soluble vitamin biosynthetic process (GO:0042362)2.78438503
87regulation of keratinocyte differentiation (GO:0045616)2.78408617
88surfactant homeostasis (GO:0043129)2.77842462
89diol metabolic process (GO:0034311)2.77615617
90regulation of apoptotic process involved in morphogenesis (GO:1902337)2.77011188
91positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.76549027
92actin filament depolymerization (GO:0030042)2.74795094
93maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.74780911
94regulation of cell fate specification (GO:0042659)2.74712299
95regulation of cellular extravasation (GO:0002691)2.74325330
96mesodermal cell differentiation (GO:0048333)2.73925308
97pentose-phosphate shunt (GO:0006098)2.72901233
98renal absorption (GO:0070293)2.72838681
99fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72771502
100fructose metabolic process (GO:0006000)2.72733436
101ceramide catabolic process (GO:0046514)2.72238604
102regulation of pseudopodium assembly (GO:0031272)2.71759754
103hormone catabolic process (GO:0042447)2.71505889
104regulation of chemokine secretion (GO:0090196)2.71454316
105regulation of SMAD protein import into nucleus (GO:0060390)2.70624718
106regulation of Cdc42 GTPase activity (GO:0043088)2.69167180
107transcytosis (GO:0045056)2.68302777
108regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.68269231
109sphingolipid catabolic process (GO:0030149)2.67897333
110mammary gland epithelial cell differentiation (GO:0060644)2.67653089
111regulation of cholesterol metabolic process (GO:0090181)2.67026857
112gap junction assembly (GO:0016264)2.66417527
113digestive system process (GO:0022600)2.66302935
114membrane lipid catabolic process (GO:0046466)2.66291745
115positive regulation of epidermis development (GO:0045684)2.64602184
116regulation of respiratory burst (GO:0060263)2.64544560
117regulation of cardioblast differentiation (GO:0051890)2.64259692
118keratinocyte development (GO:0003334)2.63244678
119regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63033936
120skin morphogenesis (GO:0043589)2.62095489
121glomerular filtration (GO:0003094)2.61503928
122regulation of cholesterol biosynthetic process (GO:0045540)2.61334652
123positive regulation of protein localization to plasma membrane (GO:1903078)2.60346926
124cell-cell junction assembly (GO:0007043)2.59787090
125negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.58991964
126protein retention in ER lumen (GO:0006621)2.57472652
127glutamine family amino acid biosynthetic process (GO:0009084)2.56872181
128embryonic process involved in female pregnancy (GO:0060136)2.56481721
129antimicrobial humoral response (GO:0019730)2.55342076
130maternal placenta development (GO:0001893)2.55184775
131positive regulation of pseudopodium assembly (GO:0031274)2.53735735
132oligosaccharide biosynthetic process (GO:0009312)2.53209571
133oligosaccharide catabolic process (GO:0009313)2.53076606
134nonribosomal peptide biosynthetic process (GO:0019184)2.52858321
135establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.52319219
136protein localization to endosome (GO:0036010)2.52243022
137positive regulation of respiratory burst (GO:0060267)2.51780552
138antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51183680
139antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51183680
140ear development (GO:0043583)2.50843117
141lung-associated mesenchyme development (GO:0060484)2.50841268
142flavonoid metabolic process (GO:0009812)2.50689379
143* keratinocyte differentiation (GO:0030216)2.49721956
144establishment or maintenance of bipolar cell polarity (GO:0061245)2.49702845
145establishment or maintenance of apical/basal cell polarity (GO:0035088)2.49702845
146modified amino acid transport (GO:0072337)2.49679438
147renal system development (GO:0072001)2.49598167
148positive regulation of glycoprotein biosynthetic process (GO:0010560)2.49426196
149glucose 6-phosphate metabolic process (GO:0051156)2.48832974
150citrulline biosynthetic process (GO:0019240)2.47909086
151keratinocyte proliferation (GO:0043616)2.47860757
152antibacterial humoral response (GO:0019731)2.47544389
153positive regulation of fatty acid beta-oxidation (GO:0032000)2.46834707
154nitrogen cycle metabolic process (GO:0071941)2.46298021
155regulation of translational fidelity (GO:0006450)2.45793849
156semaphorin-plexin signaling pathway (GO:0071526)2.45736226
157regulation of proton transport (GO:0010155)2.45354572
158regulation of viral release from host cell (GO:1902186)2.45307406
159pyrimidine-containing compound transmembrane transport (GO:0072531)2.43954513
160regulation of fatty acid beta-oxidation (GO:0031998)2.43320517
161thyroid hormone metabolic process (GO:0042403)2.42777457
162auditory receptor cell differentiation (GO:0042491)2.42395541
163regulation of systemic arterial blood pressure by hormone (GO:0001990)2.40456651
164endocrine process (GO:0050886)2.40456651

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.75682198
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03344107
3ZNF263_19887448_ChIP-Seq_K562_Human2.67508656
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.49005350
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.43332621
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.38713378
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.36388617
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.30904338
9* CDX2_20551321_ChIP-Seq_CACO-2_Human2.29101178
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22991161
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22718515
12GATA6_25053715_ChIP-Seq_YYC3_Human2.13854315
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.10119539
14* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.08012171
15SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.06427735
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03054053
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03054053
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03054053
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.00502061
20RACK7_27058665_Chip-Seq_MCF-7_Human1.97075428
21GATA4_25053715_ChIP-Seq_YYC3_Human1.91745121
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90697020
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.85722368
24TCF3_18692474_ChIP-Seq_MEFs_Mouse1.84286440
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83601271
26* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.83135326
27* ATF3_27146783_Chip-Seq_COLON_Human1.82475116
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81837584
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81168618
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.80644965
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75983036
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.75109260
33SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.73279331
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.72806108
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72789990
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.71939126
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71748383
38AR_21909140_ChIP-Seq_LNCAP_Human1.70579343
39* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.70180243
40E2F7_22180533_ChIP-Seq_HELA_Human1.66620274
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.64339931
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64062612
43CLOCK_20551151_ChIP-Seq_293T_Human1.63018033
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.60172821
45* SOX2_20726797_ChIP-Seq_SW620_Human1.56484875
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.55837640
47SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54593401
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54593401
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50385659
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49395116
51SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45385148
52* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.42152886
53PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37498681
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.36920967
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.35839298
56EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.35442679
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.34480755
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34042119
59TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32212983
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.31017307
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.30177444
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29815746
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29656897
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.28402953
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.28343214
66* KLF5_25053715_ChIP-Seq_YYC3_Human1.28099504
67SMC4_20622854_ChIP-Seq_HELA_Human1.26859374
68SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.26541929
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.25164399
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.23953983
71TP63_22573176_ChIP-Seq_HFKS_Human1.23656661
72P68_20966046_ChIP-Seq_HELA_Human1.23065146
73* MYC_22102868_ChIP-Seq_BL_Human1.21960570
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21372350
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20653536
76KDM2B_26808549_Chip-Seq_K562_Human1.20559709
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20111738
78* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.19810327
79VDR_24763502_ChIP-Seq_THP-1_Human1.19746638
80* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19627646
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19465268
82LXR_22292898_ChIP-Seq_THP-1_Human1.18735280
83LXR_22158963_ChIP-Seq_LIVER_Mouse1.18006314
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16576181
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16120288
86EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15602630
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15398154
88GATA3_24758297_ChIP-Seq_MCF-7_Human1.14968120
89BCOR_27268052_Chip-Seq_Bcells_Human1.14672906
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12164000
91NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12074095
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12054257
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11761550
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.09708723
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08390614
96CHD1_26751641_Chip-Seq_LNCaP_Human1.07386107
97FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06465619
98MYC_18555785_ChIP-Seq_MESCs_Mouse1.06322958
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06288948
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05981624
101* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05593171
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05513007
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.04851111
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04297941
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03495867
106TCF7_22412390_ChIP-Seq_EML_Mouse1.02455792
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00099491
108KDM2B_26808549_Chip-Seq_DND41_Human0.99944718
109JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99698938
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99102641
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98572305
112ELF5_23300383_ChIP-Seq_T47D_Human0.98566581
113CREB1_26743006_Chip-Seq_LNCaP_Human0.98136403
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98100304
115* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.97963958
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97664654
117* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97585404
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97244607
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97026875
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96282957
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94527714
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94453321
123AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94093870
124KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93502133
125* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93332652
126* VDR_21846776_ChIP-Seq_THP-1_Human0.93041033
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92965091
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92689819
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92607268
130NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92451775
131NCOR1_26117541_ChIP-Seq_K562_Human0.92356751
132GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91511224
133BCL6_27268052_Chip-Seq_Bcells_Human0.90416856
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89905388
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85745456
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.85551691
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.84688819
138TP53_22127205_ChIP-Seq_IMR90_Human0.83398801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.54010918
2* MP0010234_abnormal_vibrissa_follicle3.87035416
3MP0010352_gastrointestinal_tract_polyps3.36569485
4MP0002254_reproductive_system_inflammat3.29370701
5MP0003705_abnormal_hypodermis_morpholog3.00935714
6MP0000537_abnormal_urethra_morphology2.88129560
7* MP0002796_impaired_skin_barrier2.76964921
8MP0001849_ear_inflammation2.54541216
9MP0002139_abnormal_hepatobiliary_system2.54538027
10MP0003300_gastrointestinal_ulcer2.50316034
11MP0003191_abnormal_cellular_cholesterol2.49124697
12MP0003566_abnormal_cell_adhesion2.46638447
13MP0001666_abnormal_nutrient_absorption2.38240562
14MP0003453_abnormal_keratinocyte_physiol2.28089988
15MP0005409_darkened_coat_color2.17774353
16MP0000462_abnormal_digestive_system2.11700337
17MP0005451_abnormal_body_composition2.09998192
18MP0005058_abnormal_lysosome_morphology2.07903229
19* MP0002098_abnormal_vibrissa_morphology2.07573068
20* MP0005501_abnormal_skin_physiology2.04216368
21MP0000383_abnormal_hair_follicle1.89330368
22MP0003878_abnormal_ear_physiology1.85179603
23MP0005377_hearing/vestibular/ear_phenot1.85179603
24MP0005085_abnormal_gallbladder_physiolo1.85142857
25* MP0010678_abnormal_skin_adnexa1.82826477
26MP0005365_abnormal_bile_salt1.82533853
27* MP0001216_abnormal_epidermal_layer1.79934397
28MP0005076_abnormal_cell_differentiation1.78653707
29MP0005275_abnormal_skin_tensile1.77827214
30MP0001881_abnormal_mammary_gland1.76403263
31MP0001873_stomach_inflammation1.72648030
32MP0000579_abnormal_nail_morphology1.70345936
33MP0009379_abnormal_foot_pigmentation1.67223274
34MP0003693_abnormal_embryo_hatching1.66834798
35MP0003941_abnormal_skin_development1.63644627
36MP0004858_abnormal_nervous_system1.63534564
37MP0006054_spinal_hemorrhage1.62369880
38MP0002060_abnormal_skin_morphology1.61433345
39MP0004957_abnormal_blastocyst_morpholog1.58652958
40* MP0003866_abnormal_defecation1.56819003
41* MP0000477_abnormal_intestine_morphology1.55597664
42MP0000467_abnormal_esophagus_morphology1.55556786
43MP0004947_skin_inflammation1.53857349
44* MP0000377_abnormal_hair_follicle1.51016976
45MP0005023_abnormal_wound_healing1.49553064
46MP0009053_abnormal_anal_canal1.43096573
47* MP0000490_abnormal_crypts_of1.42885256
48* MP0010155_abnormal_intestine_physiology1.40261250
49MP0000627_abnormal_mammary_gland1.37482756
50MP0004019_abnormal_vitamin_homeostasis1.34323093
51MP0004272_abnormal_basement_membrane1.33021690
52MP0005083_abnormal_biliary_tract1.32561838
53MP0008004_abnormal_stomach_pH1.31361563
54MP0003283_abnormal_digestive_organ1.30586499
55MP0005360_urolithiasis1.25092013
56MP0009780_abnormal_chondrocyte_physiolo1.24708124
57MP0009643_abnormal_urine_homeostasis1.22635972
58MP0005381_digestive/alimentary_phenotyp1.18096556
59MP0009840_abnormal_foam_cell1.12735036
60MP0002234_abnormal_pharynx_morphology1.12485112
61MP0001663_abnormal_digestive_system1.11869407
62MP0005166_decreased_susceptibility_to1.09661626
63MP0000566_synostosis1.07882324
64* MP0010771_integument_phenotype1.07282591
65MP0005367_renal/urinary_system_phenotyp1.05475700
66MP0000516_abnormal_urinary_system1.05475700
67MP0000470_abnormal_stomach_morphology1.04272582
68MP0004185_abnormal_adipocyte_glucose1.03067008
69MP0002086_abnormal_extraembryonic_tissu1.03064197
70MP0003119_abnormal_digestive_system1.01703216
71MP0005666_abnormal_adipose_tissue1.01473003
72MP0001730_embryonic_growth_arrest1.01202508
73MP0003315_abnormal_perineum_morphology1.01060537
74MP0001765_abnormal_ion_homeostasis1.00371718
75MP0000538_abnormal_urinary_bladder0.99805562
76MP0004782_abnormal_surfactant_physiolog0.99015310
77MP0004043_abnormal_pH_regulation0.98727539
78* MP0000762_abnormal_tongue_morphology0.95767277
79MP0005636_abnormal_mineral_homeostasis0.95745503
80MP0002136_abnormal_kidney_physiology0.95134958
81MP0003879_abnormal_hair_cell0.93481240
82MP0000858_altered_metastatic_potential0.92605150
83MP0004381_abnormal_hair_follicle0.92294455
84MP0000613_abnormal_salivary_gland0.91845984
85MP0008260_abnormal_autophagy0.91637467
86* MP0009931_abnormal_skin_appearance0.87904446
87MP0001756_abnormal_urination0.87706970
88MP0000678_abnormal_parathyroid_gland0.87288414
89MP0000647_abnormal_sebaceous_gland0.86976691
90MP0000350_abnormal_cell_proliferation0.85776874
91MP0000681_abnormal_thyroid_gland0.85722904
92MP0002084_abnormal_developmental_patter0.85300625
93MP0010329_abnormal_lipoprotein_level0.82949598
94MP0000465_gastrointestinal_hemorrhage0.82338284
95MP0001672_abnormal_embryogenesis/_devel0.81017212
96MP0005380_embryogenesis_phenotype0.81017212
97MP0001191_abnormal_skin_condition0.80446573
98MP0005248_abnormal_Harderian_gland0.79793799
99MP0003329_amyloid_beta_deposits0.79776498
100MP0010030_abnormal_orbit_morphology0.79524787
101MP0002085_abnormal_embryonic_tissue0.78152702
102MP0001727_abnormal_embryo_implantation0.77647351
103MP0003868_abnormal_feces_composition0.77618972
104MP0002088_abnormal_embryonic_growth/wei0.77144087
105MP0003984_embryonic_growth_retardation0.76585578
106MP0004197_abnormal_fetal_growth/weight/0.76382213
107MP0002166_altered_tumor_susceptibility0.76150278
108MP0002876_abnormal_thyroid_physiology0.75750958
109MP0008875_abnormal_xenobiotic_pharmacok0.75486524
110MP0000427_abnormal_hair_cycle0.75239365
111MP0002111_abnormal_tail_morphology0.74994045
112MP0003638_abnormal_response/metabolism_0.74672821
113MP0002877_abnormal_melanocyte_morpholog0.72714217
114MP0002653_abnormal_ependyma_morphology0.71941469
115MP0010307_abnormal_tumor_latency0.71321302
116MP0002118_abnormal_lipid_homeostasis0.70534647
117MP0003075_altered_response_to0.70466251
118* MP0001664_abnormal_digestion0.70339680
119MP0001697_abnormal_embryo_size0.69987345
120MP0000609_abnormal_liver_physiology0.69330614
121MP0005025_abnormal_response_to0.65827356
122MP0001346_abnormal_lacrimal_gland0.65516179
123MP0002006_tumorigenesis0.64735033
124MP0003806_abnormal_nucleotide_metabolis0.64734338
125MP0005670_abnormal_white_adipose0.64413041
126MP0003936_abnormal_reproductive_system0.64351755
127MP0003183_abnormal_peptide_metabolism0.64087047
128MP0002080_prenatal_lethality0.63540284
129MP0002896_abnormal_bone_mineralization0.63068929
130MP0009333_abnormal_splenocyte_physiolog0.62847008
131MP0003115_abnormal_respiratory_system0.62154952
132MP0003303_peritoneal_inflammation0.61951927
133* MP0001845_abnormal_inflammatory_respons0.61843637
134MP0002138_abnormal_hepatobiliary_system0.61435462
135* MP0000367_abnormal_coat/_hair0.59656852

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.32442322
2Onycholysis (HP:0001806)5.86033323
3Milia (HP:0001056)5.62506470
4Fragile nails (HP:0001808)4.94295235
5Atrophic scars (HP:0001075)4.32037865
6Woolly hair (HP:0002224)4.19359344
7Plantar hyperkeratosis (HP:0007556)3.96376325
8Nail dystrophy (HP:0008404)3.56037214
9Biliary tract neoplasm (HP:0100574)3.43409765
10Hyperactive renin-angiotensin system (HP:0000841)3.43287593
11Ileus (HP:0002595)3.40846162
12Decreased circulating renin level (HP:0003351)3.26865598
13Flat acetabular roof (HP:0003180)3.21034092
14Micronodular cirrhosis (HP:0001413)3.14551092
15Abnormality of chloride homeostasis (HP:0011422)3.10340461
16Interstitial pulmonary disease (HP:0006530)3.04294232
17Abnormality of monocarboxylic acid metabolism (HP:0010996)2.98698858
18Abnormality of renin-angiotensin system (HP:0000847)2.90884281
19Abdominal distention (HP:0003270)2.90655388
20Malnutrition (HP:0004395)2.86157677
21Abnormality of small intestinal villus morphology (HP:0011472)2.85731330
22Villous atrophy (HP:0011473)2.85731330
23Rectal prolapse (HP:0002035)2.85177730
24Pustule (HP:0200039)2.82334729
25Abnormality of the gastric mucosa (HP:0004295)2.75340552
26Hemorrhage of the eye (HP:0011885)2.73168233
27Esophageal atresia (HP:0002032)2.72192490
28Dehydration (HP:0001944)2.71616277
29Hypoplasia of dental enamel (HP:0006297)2.70546508
30Alopecia of scalp (HP:0002293)2.62616004
31Abnormal blistering of the skin (HP:0008066)2.60071365
32Chronic bronchitis (HP:0004469)2.49131545
33Gastrointestinal carcinoma (HP:0002672)2.48952602
34Malignant gastrointestinal tract tumors (HP:0006749)2.48952602
35Abnormality of the distal phalanges of the toes (HP:0010182)2.47412769
36Distal lower limb muscle weakness (HP:0009053)2.46426858
37Abnormal biliary tract morphology (HP:0012440)2.45881819
38Increased cerebral lipofuscin (HP:0011813)2.45282623
39Flattened epiphyses (HP:0003071)2.42872542
40Hypotrichosis (HP:0001006)2.41913302
41Trismus (HP:0000211)2.41355691
42Eczematoid dermatitis (HP:0000976)2.38414771
43Abnormality of liposaccharide metabolism (HP:0010968)2.38230723
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.38230723
45Abnormality of glycolipid metabolism (HP:0010969)2.38230723
46Esophageal varix (HP:0002040)2.37054520
47Abnormal tarsal ossification (HP:0008369)2.33406550
48Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.30683442
49Ureteral stenosis (HP:0000071)2.30553005
50Uterine neoplasm (HP:0010784)2.29399508
51Gout (HP:0001997)2.27814475
52Ridged nail (HP:0001807)2.26738763
53Fat malabsorption (HP:0002630)2.25298918
54Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.25103402
55Bone pain (HP:0002653)2.24464019
56Increased neuronal autofluorescent lipopigment (HP:0002074)2.24034725
57Axonal loss (HP:0003447)2.23973389
58Palmoplantar hyperkeratosis (HP:0000972)2.23460798
59Increased IgE level (HP:0003212)2.23414867
60Renal salt wasting (HP:0000127)2.23121015
61Hypotension (HP:0002615)2.21325330
62Short humerus (HP:0005792)2.20650166
63Ependymoma (HP:0002888)2.19961647
64Systemic lupus erythematosus (HP:0002725)2.19423738
65Abnormality of the distal phalanx of the thumb (HP:0009617)2.18517411
66Abnormality of nail color (HP:0100643)2.18335865
67Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.17768257
68Vertebral hypoplasia (HP:0008417)2.17768257
69* Pili torti (HP:0003777)2.17004092
70Abnormality of the nasal mucosa (HP:0000433)2.15116253
71Dysostosis multiplex (HP:0000943)2.14156229
72Chronic diarrhea (HP:0002028)2.13617491
73Advanced eruption of teeth (HP:0006288)2.13402456
74Fragile skin (HP:0001030)2.13063570
75Pterygium (HP:0001059)2.13052577
76Abnormality of carpal bone ossification (HP:0006257)2.12674200
77Palmar hyperkeratosis (HP:0010765)2.12490560
78Ureteral obstruction (HP:0006000)2.11859745
79Thick nail (HP:0001805)2.10791472
80Septate vagina (HP:0001153)2.10558349
81Nasal polyposis (HP:0100582)2.10523362
82Abnormal vertebral ossification (HP:0100569)2.10371923
83Glomerulosclerosis (HP:0000096)2.05833383
84Focal segmental glomerulosclerosis (HP:0000097)2.05539310
85Hyperaldosteronism (HP:0000859)2.05436615
86Hypoplastic labia majora (HP:0000059)2.05419311
87Aplasia/hypoplasia of the humerus (HP:0006507)2.05374571
88Vertebral clefting (HP:0008428)2.03759658
89Mucopolysacchariduria (HP:0008155)2.00538061
90Urinary glycosaminoglycan excretion (HP:0003541)2.00538061
91Alkalosis (HP:0001948)1.98984311
92Premature loss of primary teeth (HP:0006323)1.97791040
93Distal lower limb amyotrophy (HP:0008944)1.97743961
94Hyponatremia (HP:0002902)1.97669749
95Metabolic alkalosis (HP:0200114)1.97033417
96* Abnormal hair laboratory examination (HP:0003328)1.96877714
97Amelogenesis imperfecta (HP:0000705)1.96545010
98Mildly elevated creatine phosphokinase (HP:0008180)1.96482300
99Protuberant abdomen (HP:0001538)1.96169874
100Neoplasm of the rectum (HP:0100743)1.95656325
101Spinal cord compression (HP:0002176)1.95133121
102Hydroxyprolinuria (HP:0003080)1.93811256
103Abnormality of proline metabolism (HP:0010907)1.93811256
104Intrahepatic cholestasis (HP:0001406)1.93591227
105Wide cranial sutures (HP:0010537)1.93555711
106Broad face (HP:0000283)1.92780580
107Lip pit (HP:0100267)1.92578954
108Hypophosphatemia (HP:0002148)1.92241356
109Abnormality of the 1st metacarpal (HP:0010009)1.92011786
110Loss of speech (HP:0002371)1.91785557
111Cervical subluxation (HP:0003308)1.90581921
112Growth hormone excess (HP:0000845)1.90465819
113Ventricular tachycardia (HP:0004756)1.90230116
114Aplasia cutis congenita (HP:0001057)1.89799451
115Widely patent fontanelles and sutures (HP:0004492)1.86568208
116Multiple lipomas (HP:0001012)1.86565930
117Hyperphosphatemia (HP:0002905)1.86384986
118Abnormality of the salivary glands (HP:0010286)1.85847900
119Shawl scrotum (HP:0000049)1.85234263
120Short nail (HP:0001799)1.85202867
121Upper limb amyotrophy (HP:0009129)1.84830105
122Distal upper limb amyotrophy (HP:0007149)1.84830105
123Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84118624
124Abnormality of polysaccharide metabolism (HP:0011012)1.84118624
125Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84118624
126Neoplasm of the small intestine (HP:0100833)1.83980787
127Anonychia (HP:0001798)1.83824522
128Abnormality of the proximal phalanges of the hand (HP:0009834)1.81742973
129Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81245061
130Progressive sensorineural hearing impairment (HP:0000408)1.79931563
131Cardiomegaly (HP:0001640)1.78602267
132Cheilitis (HP:0100825)1.77861345
133Abnormality of the labia majora (HP:0012881)1.77792320
134Severe short stature (HP:0003510)1.77357404
135Hyperkalemia (HP:0002153)1.77231383
136Renal tubular acidosis (HP:0001947)1.77162142
137Acanthosis nigricans (HP:0000956)1.76983320
138Hyperparathyroidism (HP:0000843)1.76235967
139Subcapsular cataract (HP:0000523)1.74725336
140Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.72330031
141Deviation of the thumb (HP:0009603)1.71540812
142Myopathic facies (HP:0002058)1.71135353
143Selective tooth agenesis (HP:0001592)1.69804573
144Thin bony cortex (HP:0002753)1.69347958
145Ulnar bowing (HP:0003031)1.68763552
146Subacute progressive viral hepatitis (HP:0006572)1.67481503
147Hand muscle atrophy (HP:0009130)1.67026629
148Ankyloglossia (HP:0010296)1.66263650
149Abnormality of renal excretion (HP:0011036)1.65287750
150Vacuolated lymphocytes (HP:0001922)1.64740570
151Progressive hearing impairment (HP:0001730)1.63700068
152Ovarian neoplasm (HP:0100615)1.63567209
153Hypoalbuminemia (HP:0003073)1.63527099
154Abnormal albumin level (HP:0012116)1.63527099
155Short phalanx of the thumb (HP:0009660)1.61993863
156Colon cancer (HP:0003003)1.60324345
157Bronchomalacia (HP:0002780)1.60159449
158Germ cell neoplasia (HP:0100728)1.58369782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA27.62263248
2MST43.62828576
3FRK2.60216829
4RPS6KB22.52851039
5SMG12.42495422
6MST1R2.39938834
7EEF2K2.36251646
8MAP2K22.30539237
9RIPK12.25191317
10IRAK32.24459659
11ERN12.17102999
12PTK62.00633717
13FER1.90045893
14PAK41.89979875
15LATS11.85736180
16LMTK21.85576019
17MAPKAPK31.77356589
18MAP3K21.76060506
19CDK121.75742390
20TRIB31.72470933
21STK101.72104811
22PKN21.66142864
23EPHB11.64684884
24PTK21.62754523
25MAP3K31.55635374
26MET1.54640995
27EPHB21.53765928
28LRRK21.51274109
29TESK11.46507869
30NME11.35346474
31PIK3CA1.33675562
32PRKCI1.31749777
33ACVR1B1.29471089
34SIK11.28865813
35GRK61.24753382
36PRKG21.23194554
37MAP3K101.22379749
38MATK1.20206019
39PRPF4B1.18802594
40AKT31.18338654
41MAP3K81.11582762
42STK241.06560076
43SCYL21.01409174
44STK38L1.00768992
45BMX0.95126349
46TAOK30.93781280
47NEK10.89431836
48TTK0.89206027
49EPHA30.86909833
50TAOK10.86073815
51FGFR40.84959413
52DDR20.84882116
53CDC42BPA0.83727520
54WNK40.82608018
55CDK60.76885201
56PRKD20.74437915
57TBK10.74269017
58PDPK10.72233298
59TTN0.71668941
60NEK60.70250034
61MAP3K120.70119820
62MAP2K10.67929465
63AURKB0.67387359
64MTOR0.66508243
65IRAK20.65572710
66ERBB20.63156626
67MAPK150.60725712
68RPS6KA20.59172094
69IRAK40.58998953
70IRAK10.58776613
71NEK20.58637025
72ZAP700.58568266
73STK30.58244487
74CHUK0.57525108
75ICK0.57482387
76PDGFRA0.56484549
77KSR20.54614882
78MAP3K110.54116582
79ARAF0.54063809
80MAP4K10.53957217
81PAK20.52921213
82STK390.52541496
83DYRK1B0.52332444
84NME20.48536926
85CDK70.48465795
86RIPK40.48330717
87MAP3K70.47945477
88MYLK0.46920858
89MAP2K60.46555173
90MAP3K140.45420669
91TGFBR20.45062735
92MARK20.43431016
93ALK0.42813186
94TYK20.42689154
95ILK0.42476795
96FLT30.42136711
97RPS6KA40.41029505
98MAP3K10.40950242
99RET0.40513166
100CSF1R0.40222630
101TNK20.39726178
102TRPM70.39587797
103PAK10.39346404
104FGFR10.38547834
105PRKAA20.38279121
106LATS20.37905238
107PASK0.37437847
108MAP3K90.37251511
109MAPKAPK20.36997488
110PDGFRB0.36583078
111GSK3A0.36561042
112MAP3K130.36544498
113NUAK10.36490187
114TSSK60.35169856
115CSK0.34564675
116TESK20.34323489
117DMPK0.34167208
118RPS6KA10.33953391
119NLK0.33392386
120WNK30.33370144
121MAPK110.32985858
122CDK40.32669087
123AKT20.32104919
124RPS6KC10.32104687
125RPS6KL10.32104687
126TAOK20.32081068
127TGFBR10.31472146
128MAP3K60.30844857
129MAP2K30.30553454
130CAMK1D0.30348511
131PIM20.30093359
132MELK0.29870705
133PIM10.28517800
134CAMK2G0.28181600
135PDK20.28085035
136PDK10.25358555
137FGFR30.25062026
138OXSR10.24933407
139SIK30.22223202

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049753.05161846
2Mineral absorption_Homo sapiens_hsa049782.90319568
3Tight junction_Homo sapiens_hsa045302.44140239
4Renin-angiotensin system_Homo sapiens_hsa046142.33118387
5Adherens junction_Homo sapiens_hsa045202.28077348
6Bladder cancer_Homo sapiens_hsa052192.07513592
7Galactose metabolism_Homo sapiens_hsa000522.06050164
8Sulfur metabolism_Homo sapiens_hsa009202.05494719
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.04931040
10Caffeine metabolism_Homo sapiens_hsa002321.99378552
11Protein digestion and absorption_Homo sapiens_hsa049741.89893078
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.89519733
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.82163461
14Fructose and mannose metabolism_Homo sapiens_hsa000511.80070999
15Arginine biosynthesis_Homo sapiens_hsa002201.78856500
16Hippo signaling pathway_Homo sapiens_hsa043901.73955907
17Small cell lung cancer_Homo sapiens_hsa052221.73404859
18Phenylalanine metabolism_Homo sapiens_hsa003601.72650085
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.70362072
20Thyroid cancer_Homo sapiens_hsa052161.64747077
21Vitamin digestion and absorption_Homo sapiens_hsa049771.62227525
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50217457
23ECM-receptor interaction_Homo sapiens_hsa045121.48331199
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47105283
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39443519
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.34781329
27Glutathione metabolism_Homo sapiens_hsa004801.34436833
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33685198
29PPAR signaling pathway_Homo sapiens_hsa033201.25859123
30Folate biosynthesis_Homo sapiens_hsa007901.24760257
31Basal cell carcinoma_Homo sapiens_hsa052171.23555096
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22505407
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.22145478
34Chemical carcinogenesis_Homo sapiens_hsa052041.20085957
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.17814910
36Proteoglycans in cancer_Homo sapiens_hsa052051.17387554
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14916306
38Toxoplasmosis_Homo sapiens_hsa051451.14704886
39Other glycan degradation_Homo sapiens_hsa005111.13809195
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13320234
41Pentose phosphate pathway_Homo sapiens_hsa000301.10722764
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.10097248
43Amoebiasis_Homo sapiens_hsa051461.08206026
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07393794
45Hepatitis C_Homo sapiens_hsa051601.07295232
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05538053
47Antigen processing and presentation_Homo sapiens_hsa046121.04978873
48p53 signaling pathway_Homo sapiens_hsa041151.03333731
49Focal adhesion_Homo sapiens_hsa045101.02484031
50Bile secretion_Homo sapiens_hsa049761.01653192
51Arginine and proline metabolism_Homo sapiens_hsa003301.00894954
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00209582
53Endometrial cancer_Homo sapiens_hsa052130.99735343
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96052028
55Histidine metabolism_Homo sapiens_hsa003400.94740484
56Retinol metabolism_Homo sapiens_hsa008300.94214134
57Chronic myeloid leukemia_Homo sapiens_hsa052200.91678229
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91519628
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.91436414
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91261210
61Pancreatic secretion_Homo sapiens_hsa049720.89273733
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88190667
63Thyroid hormone synthesis_Homo sapiens_hsa049180.87927556
64Fatty acid biosynthesis_Homo sapiens_hsa000610.82994578
65Fatty acid degradation_Homo sapiens_hsa000710.82618540
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79844613
67Tyrosine metabolism_Homo sapiens_hsa003500.78974752
68Legionellosis_Homo sapiens_hsa051340.78109379
69Apoptosis_Homo sapiens_hsa042100.76919476
70Vibrio cholerae infection_Homo sapiens_hsa051100.76850443
71Hedgehog signaling pathway_Homo sapiens_hsa043400.74680294
72Salmonella infection_Homo sapiens_hsa051320.74358467
73Pathways in cancer_Homo sapiens_hsa052000.73449083
74Linoleic acid metabolism_Homo sapiens_hsa005910.73417174
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72680742
76Arachidonic acid metabolism_Homo sapiens_hsa005900.71890983
77TGF-beta signaling pathway_Homo sapiens_hsa043500.71715938
78Acute myeloid leukemia_Homo sapiens_hsa052210.70507354
79Notch signaling pathway_Homo sapiens_hsa043300.70462243
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69995320
81Glycerolipid metabolism_Homo sapiens_hsa005610.69413497
82Ribosome_Homo sapiens_hsa030100.69176560
83N-Glycan biosynthesis_Homo sapiens_hsa005100.69071688
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.68229734
85Pancreatic cancer_Homo sapiens_hsa052120.68094640
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.65568615
87Shigellosis_Homo sapiens_hsa051310.65138489
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64774189
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63146106
90* MicroRNAs in cancer_Homo sapiens_hsa052060.61443364
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61103996
92Viral carcinogenesis_Homo sapiens_hsa052030.60868967
93HIF-1 signaling pathway_Homo sapiens_hsa040660.58848704
94Influenza A_Homo sapiens_hsa051640.57886304
95ABC transporters_Homo sapiens_hsa020100.57427102
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56106377
97VEGF signaling pathway_Homo sapiens_hsa043700.56040339
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54240569
99Selenocompound metabolism_Homo sapiens_hsa004500.54133989
100Starch and sucrose metabolism_Homo sapiens_hsa005000.53828629
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52691414
102Carbon metabolism_Homo sapiens_hsa012000.52291776
103Prostate cancer_Homo sapiens_hsa052150.52254610
104AMPK signaling pathway_Homo sapiens_hsa041520.52154259
105Insulin signaling pathway_Homo sapiens_hsa049100.51781083
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50157462
107Sulfur relay system_Homo sapiens_hsa041220.49483367
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49080637
109mTOR signaling pathway_Homo sapiens_hsa041500.48992079
110Fatty acid metabolism_Homo sapiens_hsa012120.48768234
111TNF signaling pathway_Homo sapiens_hsa046680.48370526
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.48338045
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47996570
114Sphingolipid metabolism_Homo sapiens_hsa006000.47445863
115Staphylococcus aureus infection_Homo sapiens_hsa051500.47144675
116Insulin resistance_Homo sapiens_hsa049310.46601503
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45531122
118Tuberculosis_Homo sapiens_hsa051520.43948036
119Leishmaniasis_Homo sapiens_hsa051400.43935757
120Lysosome_Homo sapiens_hsa041420.43500392
121Colorectal cancer_Homo sapiens_hsa052100.42740733
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.42604304
123Prolactin signaling pathway_Homo sapiens_hsa049170.42174219
124Biosynthesis of amino acids_Homo sapiens_hsa012300.42058724
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41605217
126Endocytosis_Homo sapiens_hsa041440.40298221
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38665115
128GnRH signaling pathway_Homo sapiens_hsa049120.37635849
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36498791
130Asthma_Homo sapiens_hsa053100.36109362
131Inositol phosphate metabolism_Homo sapiens_hsa005620.35909749
132Ether lipid metabolism_Homo sapiens_hsa005650.35414748
133Choline metabolism in cancer_Homo sapiens_hsa052310.34632048
134B cell receptor signaling pathway_Homo sapiens_hsa046620.32861587

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