ST20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of protein localization to mitochondrial membrane (GO:0090151)5.03525049
2DNA deamination (GO:0045006)4.98084502
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.65577893
4neutrophil activation involved in immune response (GO:0002283)4.64795216
5chaperone-mediated protein transport (GO:0072321)4.55844983
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55532297
7ATP synthesis coupled proton transport (GO:0015986)4.55532297
8protein neddylation (GO:0045116)4.15750229
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15587138
10cytidine deamination (GO:0009972)3.88490308
11cytidine metabolic process (GO:0046087)3.88490308
12cytidine catabolic process (GO:0006216)3.88490308
13neutrophil activation (GO:0042119)3.87629995
14positive regulation by symbiont of host defense response (GO:0052509)3.69054103
15modulation by symbiont of host defense response (GO:0052031)3.69054103
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69054103
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69054103
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.69054103
19modulation by symbiont of host immune response (GO:0052553)3.69054103
20protein complex biogenesis (GO:0070271)3.66966399
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63217873
22negative regulation of cell killing (GO:0031342)3.63217873
23leukocyte migration involved in inflammatory response (GO:0002523)3.59945890
24respiratory burst (GO:0045730)3.51492348
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.50814120
26granulocyte activation (GO:0036230)3.49215489
27respiratory electron transport chain (GO:0022904)3.46509588
28electron transport chain (GO:0022900)3.42799903
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.41215661
30NADH dehydrogenase complex assembly (GO:0010257)3.41215661
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.41215661
32pyrimidine ribonucleoside catabolic process (GO:0046133)3.37814269
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34726597
34positive regulation of T cell apoptotic process (GO:0070234)3.33626799
35mitochondrial respiratory chain complex assembly (GO:0033108)3.29811592
36cellular response to interleukin-15 (GO:0071350)3.21624687
37sequestering of actin monomers (GO:0042989)3.19797400
38regulation of B cell receptor signaling pathway (GO:0050855)3.16365622
39positive regulation of gamma-delta T cell activation (GO:0046645)3.14328484
40platelet dense granule organization (GO:0060155)3.13289818
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13011654
42RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13011654
43leukocyte degranulation (GO:0043299)3.07746078
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.05973695
45detection of molecule of bacterial origin (GO:0032490)3.05811120
46regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04553546
47regulation of interferon-beta biosynthetic process (GO:0045357)3.02081083
48response to interleukin-15 (GO:0070672)2.97336129
49positive regulation of interleukin-1 beta secretion (GO:0050718)2.93038822
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.92763892
51response to interferon-beta (GO:0035456)2.92325141
52negative regulation of interleukin-12 production (GO:0032695)2.91582904
53myeloid cell activation involved in immune response (GO:0002275)2.88319023
54positive regulation of mast cell activation (GO:0033005)2.87807723
55microglial cell activation (GO:0001774)2.87770354
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84719643
57neutrophil mediated immunity (GO:0002446)2.80975493
58autophagic vacuole fusion (GO:0000046)2.76838906
59viral transcription (GO:0019083)2.76633930
60response to peptidoglycan (GO:0032494)2.75476322
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73961149
62negative regulation of interleukin-1 beta production (GO:0032691)2.72998958
63hydrogen ion transmembrane transport (GO:1902600)2.71810475
64negative regulation of interleukin-1 production (GO:0032692)2.71578873
65positive regulation of interleukin-1 secretion (GO:0050716)2.71337407
66positive regulation of lymphocyte apoptotic process (GO:0070230)2.70973525
67regulation of thymocyte apoptotic process (GO:0070243)2.70860548
68leukocyte aggregation (GO:0070486)2.69544248
69inner mitochondrial membrane organization (GO:0007007)2.69091771
70macrophage activation involved in immune response (GO:0002281)2.68022992
71regulation of interleukin-1 beta secretion (GO:0050706)2.67466132
72mast cell activation (GO:0045576)2.66504459
73metallo-sulfur cluster assembly (GO:0031163)2.66266095
74iron-sulfur cluster assembly (GO:0016226)2.66266095
75positive regulation of T cell mediated cytotoxicity (GO:0001916)2.65162123
76ATP biosynthetic process (GO:0006754)2.65021399
77negative regulation of lymphocyte mediated immunity (GO:0002707)2.64947561
78immunoglobulin mediated immune response (GO:0016064)2.62751433
79purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.62241362
80translational termination (GO:0006415)2.60453605
81cellular extravasation (GO:0045123)2.60212836
82purine nucleoside triphosphate biosynthetic process (GO:0009145)2.59707455
83response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.58364479
84response to host immune response (GO:0052572)2.58364479
85cytochrome complex assembly (GO:0017004)2.58256842
86deoxyribonucleotide catabolic process (GO:0009264)2.57240064
87regulation of T cell mediated cytotoxicity (GO:0001914)2.56600849
88intracellular protein transmembrane import (GO:0044743)2.55923403
89respiratory chain complex IV assembly (GO:0008535)2.55602862
90dendritic cell migration (GO:0036336)2.55253257
91superoxide anion generation (GO:0042554)2.55161787
92deoxyribose phosphate catabolic process (GO:0046386)2.54515892
93GTP biosynthetic process (GO:0006183)2.53437913
94pantothenate metabolic process (GO:0015939)2.53089499
95detection of external biotic stimulus (GO:0098581)2.52247918
96behavioral response to nicotine (GO:0035095)2.51130650
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.50565874
98myeloid leukocyte mediated immunity (GO:0002444)2.49748956
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.48547899
100proton transport (GO:0015992)2.48521029

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.44461453
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.83812040
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.48131012
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.39404743
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.38375718
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.26896266
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.24016678
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.12837168
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69175584
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64105723
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59917430
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48307606
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.48184347
14VDR_23849224_ChIP-Seq_CD4+_Human2.37674426
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.36563185
16FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.23164309
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14490820
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10341486
19SPI1_23547873_ChIP-Seq_NB4_Human2.09237179
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.08650623
21ZNF274_21170338_ChIP-Seq_K562_Hela2.04125043
22FOXP3_21729870_ChIP-Seq_TREG_Human1.97910061
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96517801
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.96455506
25EZH2_22144423_ChIP-Seq_EOC_Human1.94913707
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83558655
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79312281
28HOXB4_20404135_ChIP-ChIP_EML_Mouse1.79051808
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.76984811
30ELK1_19687146_ChIP-ChIP_HELA_Human1.75355680
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74058898
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70508565
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.69349142
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68561949
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66226680
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64542023
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63064168
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62239045
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57576916
40GATA3_26560356_Chip-Seq_TH2_Human1.54420827
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48994862
42IRF8_27001747_Chip-Seq_BMDM_Mouse1.42659470
43GABP_19822575_ChIP-Seq_HepG2_Human1.39734485
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38828011
45* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37305574
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35743800
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32399742
48IRF1_19129219_ChIP-ChIP_H3396_Human1.32045018
49MYB_26560356_Chip-Seq_TH2_Human1.31351895
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30612709
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29593740
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28649771
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27528941
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27305797
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25011398
56* TP53_22573176_ChIP-Seq_HFKS_Human1.24635391
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.22381491
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21194716
59AR_20517297_ChIP-Seq_VCAP_Human1.20385597
60NANOG_20526341_ChIP-Seq_ESCs_Human1.20123183
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19198215
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18774031
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17997850
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.16532641
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16532641
66GATA3_27048872_Chip-Seq_THYMUS_Human1.16095553
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11576081
68BCL6_27268052_Chip-Seq_Bcells_Human1.11464511
69HTT_18923047_ChIP-ChIP_STHdh_Human1.10751268
70MYC_18940864_ChIP-ChIP_HL60_Human1.10372732
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08956725
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.05870024
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05010072
74ERG_20517297_ChIP-Seq_VCAP_Human1.01417454
75DCP1A_22483619_ChIP-Seq_HELA_Human1.01206847
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01200129
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00936260
78IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97290682
79EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96822767
80RUNX_20019798_ChIP-Seq_JUKART_Human0.96787359
81RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95385071
82VDR_22108803_ChIP-Seq_LS180_Human0.95098557
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94595409
84ER_23166858_ChIP-Seq_MCF-7_Human0.93817016
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.92547444
86SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92436488
87TTF2_22483619_ChIP-Seq_HELA_Human0.90895154
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90676054
89MYB_26560356_Chip-Seq_TH1_Human0.90538472
90UTX_26944678_Chip-Seq_JUKART_Human0.90303729
91ERA_21632823_ChIP-Seq_H3396_Human0.90095532
92YY1_22570637_ChIP-Seq_MALME-3M_Human0.89993344
93GATA3_26560356_Chip-Seq_TH1_Human0.88610296
94P300_27268052_Chip-Seq_Bcells_Human0.87253747
95NCOR_22424771_ChIP-Seq_293T_Human0.87139103
96STAT1_20625510_ChIP-Seq_HELA_Human0.84346373
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.83732430
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83433583
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83115963
100NANOG_19829295_ChIP-Seq_ESCs_Human0.82611434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.12886314
2MP0005671_abnormal_response_to3.26520897
3MP0001835_abnormal_antigen_presentation2.74393967
4MP0002277_abnormal_respiratory_mucosa2.65106229
5MP0003436_decreased_susceptibility_to2.64074857
6MP0009785_altered_susceptibility_to2.57507645
7MP0008877_abnormal_DNA_methylation2.52409061
8MP0002653_abnormal_ependyma_morphology2.49139542
9MP0001800_abnormal_humoral_immune2.41419955
10MP0005000_abnormal_immune_tolerance2.19488276
11MP0002148_abnormal_hypersensitivity_rea2.19177079
12MP0002132_abnormal_respiratory_system2.18048150
13MP0002723_abnormal_immune_serum2.16336532
14MP0003787_abnormal_imprinting2.15256465
15MP0005084_abnormal_gallbladder_morpholo2.13741317
16MP0005025_abnormal_response_to2.12227845
17MP0002419_abnormal_innate_immunity2.11487640
18MP0005464_abnormal_platelet_physiology2.11055826
19MP0000685_abnormal_immune_system2.01692849
20MP0002420_abnormal_adaptive_immunity1.99558167
21MP0001819_abnormal_immune_cell1.97347405
22MP0002452_abnormal_antigen_presenting1.94069036
23MP0005387_immune_system_phenotype1.93233933
24MP0001790_abnormal_immune_system1.93233933
25MP0001986_abnormal_taste_sensitivity1.89741597
26MP0003806_abnormal_nucleotide_metabolis1.88044645
27MP0009333_abnormal_splenocyte_physiolog1.85675792
28MP0009764_decreased_sensitivity_to1.74233075
29MP0006082_CNS_inflammation1.72743248
30MP0009379_abnormal_foot_pigmentation1.71569605
31MP0006292_abnormal_olfactory_placode1.65581687
32MP0003195_calcinosis1.62826998
33MP0000716_abnormal_immune_system1.51271748
34MP0002405_respiratory_system_inflammati1.47137626
35MP0002398_abnormal_bone_marrow1.46034632
36MP0001845_abnormal_inflammatory_respons1.45001001
37MP0005083_abnormal_biliary_tract1.44443912
38MP0003011_delayed_dark_adaptation1.41549584
39MP0003186_abnormal_redox_activity1.38951575
40MP0002163_abnormal_gland_morphology1.37291390
41MP0000689_abnormal_spleen_morphology1.37144188
42MP0003303_peritoneal_inflammation1.34782523
43MP0005075_abnormal_melanosome_morpholog1.32888112
44MP0006035_abnormal_mitochondrial_morpho1.30890220
45MP0003866_abnormal_defecation1.30059555
46MP0006036_abnormal_mitochondrial_physio1.26595684
47MP0001919_abnormal_reproductive_system1.25123971
48MP0008872_abnormal_physiological_respon1.23889944
49MP0002722_abnormal_immune_system1.23539139
50MP0002429_abnormal_blood_cell1.22310684
51MP0001533_abnormal_skeleton_physiology1.19458742
52MP0008469_abnormal_protein_level1.17198037
53MP0004142_abnormal_muscle_tone1.17118021
54MP0002736_abnormal_nociception_after1.14777915
55MP0003878_abnormal_ear_physiology1.12068202
56MP0005377_hearing/vestibular/ear_phenot1.12068202
57MP0008004_abnormal_stomach_pH1.05363941
58MP0001968_abnormal_touch/_nociception1.04455853
59MP0000015_abnormal_ear_pigmentation1.02322924
60MP0010155_abnormal_intestine_physiology1.01579899
61MP0000569_abnormal_digit_pigmentation1.01431289
62MP0000703_abnormal_thymus_morphology1.01119444
63MP0003763_abnormal_thymus_physiology0.99847544
64MP0003880_abnormal_central_pattern0.98813836
65MP0005174_abnormal_tail_pigmentation0.98596296
66MP0005085_abnormal_gallbladder_physiolo0.98268395
67MP0001764_abnormal_homeostasis0.98063520
68MP0002095_abnormal_skin_pigmentation0.96540391
69MP0001663_abnormal_digestive_system0.95885599
70MP0004742_abnormal_vestibular_system0.95786557
71MP0005389_reproductive_system_phenotype0.94800419
72MP0002102_abnormal_ear_morphology0.93198537
73MP0005645_abnormal_hypothalamus_physiol0.90807707
74MP0004381_abnormal_hair_follicle0.89642930
75MP0008058_abnormal_DNA_repair0.88869415
76MP0001905_abnormal_dopamine_level0.88329501
77MP0004883_abnormal_blood_vessel0.85442381
78MP0005310_abnormal_salivary_gland0.84888750
79MP0003121_genomic_imprinting0.83133046
80MP0000372_irregular_coat_pigmentation0.82344570
81MP0008875_abnormal_xenobiotic_pharmacok0.81308612
82MP0009697_abnormal_copulation0.78563105
83MP0002837_dystrophic_cardiac_calcinosis0.76984755
84MP0000465_gastrointestinal_hemorrhage0.76792748
85MP0006276_abnormal_autonomic_nervous0.76572803
86MP0005379_endocrine/exocrine_gland_phen0.74262704
87MP0003638_abnormal_response/metabolism_0.74155444
88MP0005551_abnormal_eye_electrophysiolog0.73017221
89MP0010386_abnormal_urinary_bladder0.72491695
90MP0000343_altered_response_to0.71946727
91MP0002928_abnormal_bile_duct0.71762559
92MP0002693_abnormal_pancreas_physiology0.65388811
93MP0006072_abnormal_retinal_apoptosis0.65158380
94MP0001485_abnormal_pinna_reflex0.65078630
95MP0005319_abnormal_enzyme/_coenzyme0.63101362
96MP0009278_abnormal_bone_marrow0.62684218
97MP0003646_muscle_fatigue0.61218951
98MP0004133_heterotaxia0.60965853
99MP0003183_abnormal_peptide_metabolism0.60891981
100MP0008260_abnormal_autophagy0.60807880

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)3.96219740
2Stomatitis (HP:0010280)3.95010150
3Elevated erythrocyte sedimentation rate (HP:0003565)3.82639904
4Acute necrotizing encephalopathy (HP:0006965)3.78326969
5Recurrent bacterial skin infections (HP:0005406)3.75816614
6Mitochondrial inheritance (HP:0001427)3.65034950
7Abnormal mitochondria in muscle tissue (HP:0008316)3.52894555
8Myositis (HP:0100614)3.33604464
9Progressive macrocephaly (HP:0004481)3.24488181
103-Methylglutaconic aciduria (HP:0003535)3.17858276
11Acute encephalopathy (HP:0006846)3.15598492
12Retrobulbar optic neuritis (HP:0100654)3.11367058
13Optic neuritis (HP:0100653)3.11367058
14Increased CSF lactate (HP:0002490)3.09634018
15Chronic obstructive pulmonary disease (HP:0006510)3.07097936
16Obstructive lung disease (HP:0006536)3.07097936
17Orchitis (HP:0100796)3.07066048
18Encephalitis (HP:0002383)3.02900594
19Hepatocellular necrosis (HP:0001404)3.02789147
20Lipid accumulation in hepatocytes (HP:0006561)2.90981547
21Increased hepatocellular lipid droplets (HP:0006565)2.90700432
22Pancreatic fibrosis (HP:0100732)2.90198675
23Absent rod-and cone-mediated responses on ERG (HP:0007688)2.83908944
24Pancreatic cysts (HP:0001737)2.83607865
25Molar tooth sign on MRI (HP:0002419)2.80230915
26Abnormality of midbrain morphology (HP:0002418)2.80230915
27Hepatic necrosis (HP:0002605)2.79242905
28Renal Fanconi syndrome (HP:0001994)2.77922544
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.76682330
30Recurrent gram-negative bacterial infections (HP:0005420)2.68449069
31Increased intramyocellular lipid droplets (HP:0012240)2.67335216
32Abnormality of macrophages (HP:0004311)2.65229226
33Eczematoid dermatitis (HP:0000976)2.62956289
34Abnormality of the heme biosynthetic pathway (HP:0010472)2.61316282
35True hermaphroditism (HP:0010459)2.60617789
36Recurrent fungal infections (HP:0002841)2.57737412
37Hypochromic microcytic anemia (HP:0004840)2.55002902
38Panhypogammaglobulinemia (HP:0003139)2.54918199
39Increased IgM level (HP:0003496)2.51671180
40Exertional dyspnea (HP:0002875)2.48338240
41Episodic fever (HP:0001954)2.47350187
42Recurrent skin infections (HP:0001581)2.44416141
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.43636622
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.43636622
45Increased muscle lipid content (HP:0009058)2.40416764
46Mediastinal lymphadenopathy (HP:0100721)2.31071526
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.30990354
48Gastrointestinal infarctions (HP:0005244)2.29721092
49Cerebral edema (HP:0002181)2.28355735
50Prolonged bleeding time (HP:0003010)2.27800470
51Hypochromic anemia (HP:0001931)2.27552099
52Meningitis (HP:0001287)2.22532598
53Sclerocornea (HP:0000647)2.19470247
54Abnormal number of erythroid precursors (HP:0012131)2.17781407
55Abnormality of T cells (HP:0002843)2.16953962
56Abnormality of renal resorption (HP:0011038)2.15639324
57Abolished electroretinogram (ERG) (HP:0000550)2.14151148
58Abnormal hemoglobin (HP:0011902)2.11919662
59Lactic acidosis (HP:0003128)2.11710625
60Abnormality of T cell number (HP:0011839)2.11639947
61Increased serum lactate (HP:0002151)2.10649251
62Abnormality of cells of the erythroid lineage (HP:0012130)2.09917267
63Recurrent cutaneous fungal infections (HP:0011370)2.09780437
64Chronic mucocutaneous candidiasis (HP:0002728)2.09780437
65Abnormal rod and cone electroretinograms (HP:0008323)2.09540046
66Keratoconjunctivitis sicca (HP:0001097)2.06658156
67T lymphocytopenia (HP:0005403)2.06398725
68Respiratory difficulties (HP:0002880)2.04996819
69Anorexia (HP:0002039)2.04897587
70Keratoconjunctivitis (HP:0001096)2.04724436
71Optic disc pallor (HP:0000543)2.04526237
72Colon cancer (HP:0003003)2.04259744
73Abnormality of alanine metabolism (HP:0010916)2.04166924
74Hyperalaninemia (HP:0003348)2.04166924
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.04166924
76Petechiae (HP:0000967)2.02122877
77Leukocytosis (HP:0001974)2.01955413
78Abnormal biliary tract physiology (HP:0012439)1.98937335
79Bile duct proliferation (HP:0001408)1.98937335
80Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98173182
81Aplastic anemia (HP:0001915)1.96274524
82Severe combined immunodeficiency (HP:0004430)1.95526529
83Microretrognathia (HP:0000308)1.94909257
84Anencephaly (HP:0002323)1.93056737
85Abnormality of T cell physiology (HP:0011840)1.92603680
86Pallor (HP:0000980)1.91539516
87Microcytic anemia (HP:0001935)1.89080156
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85851710
89Abnormality of B cell number (HP:0010975)1.85746775
90Vasculitis (HP:0002633)1.83467847
91Absent/shortened dynein arms (HP:0200106)1.83349355
92Dynein arm defect of respiratory motile cilia (HP:0012255)1.83349355
93Severe visual impairment (HP:0001141)1.80019556
94Respiratory failure (HP:0002878)1.79548800
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78997997
96Urticaria (HP:0001025)1.75593452
97Eosinophilia (HP:0001880)1.75461574
98Leukodystrophy (HP:0002415)1.75287598
99IgG deficiency (HP:0004315)1.74580958
100Abnormality of eosinophils (HP:0001879)1.74467459

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.35663416
2VRK22.91487769
3IRAK42.78275843
4BCKDK2.56710107
5RIPK42.55539624
6NUAK12.54223815
7TAOK32.44259639
8MAP4K12.38291946
9MAP3K122.33474127
10STK162.11876535
11MAP3K112.10189270
12GRK62.05294056
13TAF11.97863006
14WNK31.90008371
15DYRK21.89207129
16BLK1.77345976
17MST41.74888093
18MAP4K21.66802035
19CDK191.62597916
20CSK1.60811597
21ADRBK21.58424431
22ZAK1.58000396
23PINK11.57354399
24DYRK31.54925553
25TNK21.46525399
26SYK1.42409814
27FES1.41074257
28TLK11.40751758
29FRK1.33580907
30IKBKB1.33097172
31BTK1.32314915
32BMPR1B1.31246037
33TYK21.29327878
34IKBKE1.26474722
35VRK11.23532186
36ZAP701.20541420
37LYN1.20209835
38NME21.11768176
39IRAK11.05484852
40TEC1.05110203
41DAPK21.03184111
42GRK51.00658578
43INSRR1.00624583
44FGR1.00604059
45MATK0.90410953
46TRIM280.90150635
47MARK30.89283025
48PRKCQ0.88879102
49HCK0.88653657
50ADRBK10.87973088
51STK110.86007211
52GRK10.85983399
53TBK10.85802073
54LCK0.85727670
55CSF1R0.84766778
56MAP2K30.84582763
57MAPK130.83558396
58KDR0.82766787
59OXSR10.82037411
60ITK0.79934660
61CSNK1G30.79600568
62PTK2B0.75515247
63DAPK10.74213653
64PNCK0.72206411
65MAP2K70.70651134
66NME10.69622656
67GRK70.67757077
68JAK20.64211160
69MAP3K50.63130878
70MAP2K40.62888929
71TESK20.61816737
72KIT0.60226125
73CSNK1G20.59815801
74LRRK20.58540056
75IRAK20.57927766
76TNIK0.57570048
77SIK30.55743228
78JAK30.55182341
79ACVR1B0.54789211
80TAOK10.53974369
81CSNK1G10.50505530
82CSNK1A1L0.48905440
83PIM10.47087423
84BMPR20.46802594
85ERN10.42965504
86PRKCD0.42881107
87DAPK30.41724432
88CASK0.40986237
89CAMKK20.39706966
90EPHB10.39182631
91PRKCZ0.38838823
92ABL20.37219831
93SIK20.36150980
94MAP3K140.35846470
95SMG10.34839346
96SRPK10.34699771
97DYRK1B0.34564998
98AURKA0.34041130
99FYN0.33773066
100MAP3K30.31484128

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.33124790
2Parkinsons disease_Homo sapiens_hsa050123.76852401
3Ribosome_Homo sapiens_hsa030103.55286369
4Proteasome_Homo sapiens_hsa030503.09730796
5Primary immunodeficiency_Homo sapiens_hsa053402.58961983
6Alzheimers disease_Homo sapiens_hsa050102.37756296
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.36659740
8Huntingtons disease_Homo sapiens_hsa050162.36548203
9Protein export_Homo sapiens_hsa030602.27714211
10Graft-versus-host disease_Homo sapiens_hsa053322.11459544
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.09992429
12Allograft rejection_Homo sapiens_hsa053301.93356354
13Autoimmune thyroid disease_Homo sapiens_hsa053201.89296988
14Sulfur relay system_Homo sapiens_hsa041221.75004143
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.74129788
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.71674650
17RNA polymerase_Homo sapiens_hsa030201.68568907
18Staphylococcus aureus infection_Homo sapiens_hsa051501.55366245
19Leishmaniasis_Homo sapiens_hsa051401.53750487
20Type I diabetes mellitus_Homo sapiens_hsa049401.49982854
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.44582294
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41926829
23Hematopoietic cell lineage_Homo sapiens_hsa046401.39372703
24Cardiac muscle contraction_Homo sapiens_hsa042601.38341935
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37162348
26Homologous recombination_Homo sapiens_hsa034401.34770040
27Rheumatoid arthritis_Homo sapiens_hsa053231.34409490
28Asthma_Homo sapiens_hsa053101.31313691
29Collecting duct acid secretion_Homo sapiens_hsa049661.30672758
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30655650
31Antigen processing and presentation_Homo sapiens_hsa046121.26186317
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.26012412
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24246604
34Mismatch repair_Homo sapiens_hsa034301.22533274
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18810661
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16054154
37Osteoclast differentiation_Homo sapiens_hsa043801.15625522
38RNA degradation_Homo sapiens_hsa030181.13407950
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11681637
40Tuberculosis_Homo sapiens_hsa051521.10097410
41Sulfur metabolism_Homo sapiens_hsa009201.06796886
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05176215
43Peroxisome_Homo sapiens_hsa041461.04641814
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04201962
45Phototransduction_Homo sapiens_hsa047441.01782312
46Chemokine signaling pathway_Homo sapiens_hsa040620.99614265
47Measles_Homo sapiens_hsa051620.95227484
48Fanconi anemia pathway_Homo sapiens_hsa034600.94699745
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94385872
50Pyrimidine metabolism_Homo sapiens_hsa002400.93918311
51T cell receptor signaling pathway_Homo sapiens_hsa046600.93050960
52Legionellosis_Homo sapiens_hsa051340.92543584
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91914074
54Phagosome_Homo sapiens_hsa041450.91110641
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.89915021
56Regulation of autophagy_Homo sapiens_hsa041400.86846366
57Linoleic acid metabolism_Homo sapiens_hsa005910.84842331
58Malaria_Homo sapiens_hsa051440.83776601
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81808317
60Arachidonic acid metabolism_Homo sapiens_hsa005900.79982802
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74700399
62One carbon pool by folate_Homo sapiens_hsa006700.63446619
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62960140
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60371340
65Salmonella infection_Homo sapiens_hsa051320.59534719
66Propanoate metabolism_Homo sapiens_hsa006400.59454509
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.59088294
68Caffeine metabolism_Homo sapiens_hsa002320.56784407
69Herpes simplex infection_Homo sapiens_hsa051680.56202148
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56149722
71Shigellosis_Homo sapiens_hsa051310.53399228
72B cell receptor signaling pathway_Homo sapiens_hsa046620.53115720
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52768648
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50279271
75Tryptophan metabolism_Homo sapiens_hsa003800.49425343
76Spliceosome_Homo sapiens_hsa030400.48880526
77Viral myocarditis_Homo sapiens_hsa054160.48293249
78Metabolic pathways_Homo sapiens_hsa011000.48180694
79Purine metabolism_Homo sapiens_hsa002300.47829038
80Epstein-Barr virus infection_Homo sapiens_hsa051690.46838031
81Basal transcription factors_Homo sapiens_hsa030220.46355533
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46087756
83Morphine addiction_Homo sapiens_hsa050320.45717116
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43790058
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43338558
86Folate biosynthesis_Homo sapiens_hsa007900.42616042
87Chemical carcinogenesis_Homo sapiens_hsa052040.42366850
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42176687
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41487942
90African trypanosomiasis_Homo sapiens_hsa051430.40422900
91beta-Alanine metabolism_Homo sapiens_hsa004100.39708799
92Butanoate metabolism_Homo sapiens_hsa006500.39707035
93Selenocompound metabolism_Homo sapiens_hsa004500.39277400
94Olfactory transduction_Homo sapiens_hsa047400.38595761
95Steroid biosynthesis_Homo sapiens_hsa001000.36612570
96DNA replication_Homo sapiens_hsa030300.35412514
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35329193
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.34006437
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33752018
100Base excision repair_Homo sapiens_hsa034100.33567685

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