ST20-MTHFS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring suppressor of tumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes on chromosome 15. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.41987518
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14899542
3proteasome assembly (GO:0043248)4.14635341
4ATP synthesis coupled proton transport (GO:0015986)3.69963964
5energy coupled proton transport, down electrochemical gradient (GO:0015985)3.69963964
6protein complex biogenesis (GO:0070271)3.69844883
7L-phenylalanine catabolic process (GO:0006559)3.69677890
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.69677890
9respiratory chain complex IV assembly (GO:0008535)3.65271918
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.64171135
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.60542022
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.60542022
13NADH dehydrogenase complex assembly (GO:0010257)3.60542022
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.42454831
15L-phenylalanine metabolic process (GO:0006558)3.42454831
16respiratory electron transport chain (GO:0022904)3.41971737
17rRNA modification (GO:0000154)3.41340552
18electron transport chain (GO:0022900)3.36951738
19mitochondrial respiratory chain complex assembly (GO:0033108)3.36404864
20regulation of cellular amino acid metabolic process (GO:0006521)3.32615049
21establishment of protein localization to mitochondrial membrane (GO:0090151)3.28870422
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18966001
23cytochrome complex assembly (GO:0017004)3.17956096
24platelet dense granule organization (GO:0060155)3.17921000
25chaperone-mediated protein transport (GO:0072321)3.12808522
26protein neddylation (GO:0045116)3.11290208
27immunoglobulin mediated immune response (GO:0016064)3.11000937
28pseudouridine synthesis (GO:0001522)3.09752462
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.03315382
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.01406677
31cytidine metabolic process (GO:0046087)3.00220032
32cytidine catabolic process (GO:0006216)3.00220032
33cytidine deamination (GO:0009972)3.00220032
34antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.00151452
35DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99794767
36metallo-sulfur cluster assembly (GO:0031163)2.95595441
37iron-sulfur cluster assembly (GO:0016226)2.95595441
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94944855
39water-soluble vitamin biosynthetic process (GO:0042364)2.94568196
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92471586
41RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92471586
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90874296
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90874296
44signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90874296
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88647402
46intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88647402
47neutrophil activation involved in immune response (GO:0002283)2.88044949
48aldehyde catabolic process (GO:0046185)2.87082209
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86611891
50negative regulation of ligase activity (GO:0051352)2.86611891
51aromatic amino acid family catabolic process (GO:0009074)2.85463039
52termination of RNA polymerase III transcription (GO:0006386)2.82507530
53transcription elongation from RNA polymerase III promoter (GO:0006385)2.82507530
54S-adenosylmethionine metabolic process (GO:0046500)2.80256226
55L-methionine salvage (GO:0071267)2.80176525
56L-methionine biosynthetic process (GO:0071265)2.80176525
57amino acid salvage (GO:0043102)2.80176525
58B cell mediated immunity (GO:0019724)2.79522380
59glyoxylate metabolic process (GO:0046487)2.78231991
60signal transduction involved in DNA damage checkpoint (GO:0072422)2.77172158
61signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77172158
62response to interferon-beta (GO:0035456)2.76415818
63xenobiotic catabolic process (GO:0042178)2.75231458
64L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.74448660
65signal transduction involved in cell cycle checkpoint (GO:0072395)2.70204450
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.69012824
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68107288
68exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66409195
69protein targeting to mitochondrion (GO:0006626)2.66003399
70deoxyribonucleotide catabolic process (GO:0009264)2.64331702
71deoxyribose phosphate catabolic process (GO:0046386)2.63597513
72aerobic respiration (GO:0009060)2.62383640
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62137421
74regulation of cellular amine metabolic process (GO:0033238)2.60412169
75regulation of mitochondrial translation (GO:0070129)2.59383850
76positive regulation of interleukin-17 production (GO:0032740)2.59155581
77antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.57681106
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.57359581
79peptidyl-histidine modification (GO:0018202)2.56798096
80deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.56470553
81ribosomal small subunit assembly (GO:0000028)2.54659097
82purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.53192357
83positive regulation of ligase activity (GO:0051351)2.52674632
84tetrahydrofolate metabolic process (GO:0046653)2.51185353
85viral mRNA export from host cell nucleus (GO:0046784)2.45628569
86purine deoxyribonucleotide catabolic process (GO:0009155)2.44985824
87hydrogen ion transmembrane transport (GO:1902600)2.44176513
88rRNA methylation (GO:0031167)2.43667299
89purine-containing compound salvage (GO:0043101)2.41900327
90establishment of protein localization to mitochondrion (GO:0072655)2.39134598
91regulation of B cell receptor signaling pathway (GO:0050855)2.38899719
92antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.35843067
93protein localization to mitochondrion (GO:0070585)2.35122373
94pyrimidine ribonucleoside catabolic process (GO:0046133)2.29428238
95spliceosomal snRNP assembly (GO:0000387)2.28678679
96positive regulation of cell cycle arrest (GO:0071158)2.28182324
97base-excision repair, AP site formation (GO:0006285)2.27988030
98neutrophil activation (GO:0042119)2.27393856
99purine nucleotide salvage (GO:0032261)2.27135143
100regulation of activation of Janus kinase activity (GO:0010533)2.26725147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.33532751
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.00536312
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.40312515
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.32964055
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20805705
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.18475255
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.15963465
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03153362
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.73036713
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.70984772
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.69699331
12VDR_23849224_ChIP-Seq_CD4+_Human2.68272698
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.67053455
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.57069715
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49071910
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.48686090
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.40347867
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.39009861
19FOXP3_21729870_ChIP-Seq_TREG_Human2.33716917
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.23119760
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21864240
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.15609075
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.12463332
24HOXB4_20404135_ChIP-ChIP_EML_Mouse2.08215365
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04137193
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03994060
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.02416485
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95623916
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94757746
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93041817
31ELK1_19687146_ChIP-ChIP_HELA_Human1.85940771
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85067218
33DCP1A_22483619_ChIP-Seq_HELA_Human1.81224540
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78604877
35* SPI1_23547873_ChIP-Seq_NB4_Human1.74778590
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.67153296
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57124670
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.52011077
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51343481
40GABP_19822575_ChIP-Seq_HepG2_Human1.51056096
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47523882
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46450944
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45376386
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.45193151
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45122191
46E2F7_22180533_ChIP-Seq_HELA_Human1.44029692
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42956257
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.42321085
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40505076
50YY1_21170310_ChIP-Seq_MESCs_Mouse1.38170851
51MYB_26560356_Chip-Seq_TH2_Human1.36479630
52GATA1_22025678_ChIP-Seq_K562_Human1.36011959
53GATA3_26560356_Chip-Seq_TH2_Human1.35373235
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34010157
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29573326
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28486654
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24621773
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24414639
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20551182
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18358179
61TTF2_22483619_ChIP-Seq_HELA_Human1.18282274
62VDR_22108803_ChIP-Seq_LS180_Human1.13962590
63FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12175935
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11763413
65MYC_18940864_ChIP-ChIP_HL60_Human1.09608194
66AR_20517297_ChIP-Seq_VCAP_Human1.08840380
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02909784
68TP53_22573176_ChIP-Seq_HFKS_Human1.01174271
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.98830400
70ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98769642
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98460349
72FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97588515
73FOXA1_25329375_ChIP-Seq_VCAP_Human0.97588515
74HTT_18923047_ChIP-ChIP_STHdh_Human0.97495896
75IRF8_27001747_Chip-Seq_BMDM_Mouse0.97148985
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97017485
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96468646
78KDM5A_27292631_Chip-Seq_BREAST_Human0.94299126
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93585787
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92893225
81CIITA_25753668_ChIP-Seq_RAJI_Human0.92667944
82CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91978047
83TFEB_21752829_ChIP-Seq_HELA_Human0.91401575
84MYB_26560356_Chip-Seq_TH1_Human0.90452544
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87891897
86STAT1_20625510_ChIP-Seq_HELA_Human0.87332622
87MYC_19079543_ChIP-ChIP_MESCs_Mouse0.87317596
88STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87216852
89PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87081702
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86490270
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.85140513
92ZNF274_21170338_ChIP-Seq_K562_Hela0.85065437
93RXR_22158963_ChIP-Seq_LIVER_Mouse0.82033218
94GATA3_27048872_Chip-Seq_THYMUS_Human0.81528351
95ERG_20517297_ChIP-Seq_VCAP_Human0.81383362
96EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80491075
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79991677
98XRN2_22483619_ChIP-Seq_HELA_Human0.78349334
99SOX2_19829295_ChIP-Seq_ESCs_Human0.76692284
100NANOG_19829295_ChIP-Seq_ESCs_Human0.76692284

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.31026409
2MP0002139_abnormal_hepatobiliary_system3.19100279
3MP0001835_abnormal_antigen_presentation3.07995640
4MP0009785_altered_susceptibility_to2.83987840
5MP0003195_calcinosis2.75655755
6MP0005671_abnormal_response_to2.71142346
7MP0002138_abnormal_hepatobiliary_system2.69301598
8MP0008875_abnormal_xenobiotic_pharmacok2.67298638
9MP0009333_abnormal_splenocyte_physiolog2.40682887
10MP0005084_abnormal_gallbladder_morpholo2.32072435
11MP0003724_increased_susceptibility_to2.31575693
12MP0006036_abnormal_mitochondrial_physio2.16225446
13MP0005464_abnormal_platelet_physiology2.03708769
14MP0005000_abnormal_immune_tolerance2.00070375
15MP0002132_abnormal_respiratory_system1.99292048
16MP0002148_abnormal_hypersensitivity_rea1.94287867
17MP0005075_abnormal_melanosome_morpholog1.92941720
18MP0001800_abnormal_humoral_immune1.89273440
19MP0005025_abnormal_response_to1.89212676
20MP0002723_abnormal_immune_serum1.82467649
21MP0003186_abnormal_redox_activity1.82408636
22MP0001764_abnormal_homeostasis1.80426982
23MP0005085_abnormal_gallbladder_physiolo1.76624064
24MP0002419_abnormal_innate_immunity1.75061341
25MP0005360_urolithiasis1.69609655
26MP0002452_abnormal_antigen_presenting1.66118696
27MP0003436_decreased_susceptibility_to1.65975727
28MP0002420_abnormal_adaptive_immunity1.64522356
29MP0001819_abnormal_immune_cell1.62956684
30MP0005365_abnormal_bile_salt1.62608495
31MP0002396_abnormal_hematopoietic_system1.55415535
32MP0009697_abnormal_copulation1.52258129
33MP0008469_abnormal_protein_level1.51757170
34MP0003011_delayed_dark_adaptation1.50708192
35MP0000372_irregular_coat_pigmentation1.50693272
36MP0006035_abnormal_mitochondrial_morpho1.50488374
37MP0008058_abnormal_DNA_repair1.49713609
38MP0001790_abnormal_immune_system1.49381749
39MP0005387_immune_system_phenotype1.49381749
40MP0001845_abnormal_inflammatory_respons1.48429776
41MP0003252_abnormal_bile_duct1.47777262
42MP0002277_abnormal_respiratory_mucosa1.45779201
43MP0005332_abnormal_amino_acid1.44025658
44MP0009764_decreased_sensitivity_to1.43450845
45MP0006082_CNS_inflammation1.42388138
46MP0002398_abnormal_bone_marrow1.39477132
47MP0000685_abnormal_immune_system1.39465106
48MP0000689_abnormal_spleen_morphology1.37055274
49MP0003786_premature_aging1.36740053
50MP0005645_abnormal_hypothalamus_physiol1.35456891
51MP0000716_abnormal_immune_system1.35448786
52MP0005408_hypopigmentation1.31478522
53MP0005636_abnormal_mineral_homeostasis1.27659095
54MP0005319_abnormal_enzyme/_coenzyme1.26177580
55MP0008877_abnormal_DNA_methylation1.23390200
56MP0008872_abnormal_physiological_respon1.20695593
57MP0002429_abnormal_blood_cell1.19063337
58MP0002722_abnormal_immune_system1.18810484
59MP0002405_respiratory_system_inflammati1.17706636
60MP0003878_abnormal_ear_physiology1.15338793
61MP0005377_hearing/vestibular/ear_phenot1.15338793
62MP0010329_abnormal_lipoprotein_level1.13426258
63MP0004019_abnormal_vitamin_homeostasis1.12210565
64MP0008007_abnormal_cellular_replicative1.11448585
65MP0010094_abnormal_chromosome_stability1.10082173
66MP0003693_abnormal_embryo_hatching1.07308086
67MP0003638_abnormal_response/metabolism_1.05533668
68MP0001666_abnormal_nutrient_absorption1.02720781
69MP0010155_abnormal_intestine_physiology1.01734604
70MP0002736_abnormal_nociception_after1.01693244
71MP0000609_abnormal_liver_physiology1.01133932
72MP0005379_endocrine/exocrine_gland_phen1.00879334
73MP0009763_increased_sensitivity_to1.00769256
74MP0003075_altered_response_to0.99942122
75MP0005551_abnormal_eye_electrophysiolog0.98061959
76MP0002006_tumorigenesis0.97761655
77MP0002876_abnormal_thyroid_physiology0.97067395
78MP0002166_altered_tumor_susceptibility0.96848730
79MP0003763_abnormal_thymus_physiology0.94768943
80MP0003718_maternal_effect0.94764521
81MP0004957_abnormal_blastocyst_morpholog0.90968183
82MP0003866_abnormal_defecation0.90762300
83MP0009643_abnormal_urine_homeostasis0.88776690
84MP0002163_abnormal_gland_morphology0.88020496
85MP0005410_abnormal_fertilization0.87283599
86MP0003191_abnormal_cellular_cholesterol0.87204943
87MP0002693_abnormal_pancreas_physiology0.86592900
88MP0006072_abnormal_retinal_apoptosis0.83235847
89MP0002837_dystrophic_cardiac_calcinosis0.83083727
90MP0010386_abnormal_urinary_bladder0.82776845
91MP0000703_abnormal_thymus_morphology0.82681048
92MP0002019_abnormal_tumor_incidence0.82520457
93MP0003111_abnormal_nucleus_morphology0.82048190
94MP0008995_early_reproductive_senescence0.81838635
95MP0003303_peritoneal_inflammation0.80258452
96MP0009765_abnormal_xenobiotic_induced0.77805306
97MP0009642_abnormal_blood_homeostasis0.77736019
98MP0008873_increased_physiological_sensi0.77720228
99MP0001919_abnormal_reproductive_system0.77518429
100MP0001529_abnormal_vocalization0.76973919

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.28535203
2Acute encephalopathy (HP:0006846)4.04103278
3Mitochondrial inheritance (HP:0001427)4.02637816
4Abnormal mitochondria in muscle tissue (HP:0008316)3.99559959
5Generalized aminoaciduria (HP:0002909)3.77760354
6Renal Fanconi syndrome (HP:0001994)3.74472654
7Increased CSF lactate (HP:0002490)3.68988261
8Hepatocellular necrosis (HP:0001404)3.67583835
9Progressive macrocephaly (HP:0004481)3.57755985
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.37999283
11Hepatic necrosis (HP:0002605)3.37733931
123-Methylglutaconic aciduria (HP:0003535)3.19770585
13Cerebral edema (HP:0002181)3.13325575
14Myositis (HP:0100614)2.95948148
15Optic neuritis (HP:0100653)2.85017064
16Retrobulbar optic neuritis (HP:0100654)2.85017064
17Reduced antithrombin III activity (HP:0001976)2.84667984
18Increased hepatocellular lipid droplets (HP:0006565)2.82151164
19Stomatitis (HP:0010280)2.72740044
20Increased serum lactate (HP:0002151)2.71194328
21Elevated erythrocyte sedimentation rate (HP:0003565)2.69627343
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.63001941
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.63001941
24Orchitis (HP:0100796)2.62731946
25Lipid accumulation in hepatocytes (HP:0006561)2.59266359
26Lactic acidosis (HP:0003128)2.57339469
27Increased intramyocellular lipid droplets (HP:0012240)2.56127265
28Methylmalonic acidemia (HP:0002912)2.53764171
29Abnormality of aspartate family amino acid metabolism (HP:0010899)2.48698921
30Type I transferrin isoform profile (HP:0003642)2.44915938
31Abnormality of renal resorption (HP:0011038)2.41778922
32Lethargy (HP:0001254)2.40434417
33Glycosuria (HP:0003076)2.39157406
34Abnormality of urine glucose concentration (HP:0011016)2.39157406
35Encephalitis (HP:0002383)2.38649498
36Aplastic anemia (HP:0001915)2.38047206
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37625869
38Microvesicular hepatic steatosis (HP:0001414)2.37127764
39Abnormality of methionine metabolism (HP:0010901)2.33354226
40Abnormality of serum amino acid levels (HP:0003112)2.32314116
41Panhypogammaglobulinemia (HP:0003139)2.29982553
42Optic disc pallor (HP:0000543)2.29159349
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27894070
44Methylmalonic aciduria (HP:0012120)2.25414624
45Prolonged partial thromboplastin time (HP:0003645)2.23197656
46Exertional dyspnea (HP:0002875)2.20797332
47Hyperglycinemia (HP:0002154)2.20574078
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20500868
49Anorexia (HP:0002039)2.19647873
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.19513426
51Petechiae (HP:0000967)2.19296368
52Respiratory failure (HP:0002878)2.18478193
53Leukodystrophy (HP:0002415)2.14601143
54CNS demyelination (HP:0007305)2.14335313
55Abnormality of macrophages (HP:0004311)2.14274864
56Increased muscle lipid content (HP:0009058)2.11069113
57Decreased central vision (HP:0007663)2.10326632
58Chronic mucocutaneous candidiasis (HP:0002728)2.10154400
59Recurrent cutaneous fungal infections (HP:0011370)2.10154400
60Pancreatic cysts (HP:0001737)2.07398466
61Abnormal protein glycosylation (HP:0012346)2.07357674
62Abnormal glycosylation (HP:0012345)2.07357674
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07357674
64Abnormal protein N-linked glycosylation (HP:0012347)2.07357674
65Hypoproteinemia (HP:0003075)2.06600861
66Vacuolated lymphocytes (HP:0001922)2.03710390
67Exercise intolerance (HP:0003546)2.03039089
68Acute hepatic failure (HP:0006554)2.00172310
69Pancytopenia (HP:0001876)1.99613147
70Increased IgM level (HP:0003496)1.99406479
71Abolished electroretinogram (ERG) (HP:0000550)1.95088871
72Hypophosphatemic rickets (HP:0004912)1.94777552
73Chronic obstructive pulmonary disease (HP:0006510)1.94360098
74Obstructive lung disease (HP:0006536)1.94360098
75Recurrent abscess formation (HP:0002722)1.94152125
76Spontaneous abortion (HP:0005268)1.93137750
77Nausea (HP:0002018)1.93035403
78Meningitis (HP:0001287)1.92941838
79Hyperphosphaturia (HP:0003109)1.90377572
80Abnormality of pyrimidine metabolism (HP:0004353)1.89842744
81Abnormality of the heme biosynthetic pathway (HP:0010472)1.89365366
82True hermaphroditism (HP:0010459)1.87982407
83Pancreatic fibrosis (HP:0100732)1.86440359
84Recurrent bacterial skin infections (HP:0005406)1.84991178
85Abnormal biliary tract physiology (HP:0012439)1.84475336
86Bile duct proliferation (HP:0001408)1.84475336
87IgG deficiency (HP:0004315)1.83516041
88Keratoconjunctivitis sicca (HP:0001097)1.83195890
89Neutropenia (HP:0001875)1.82795454
90Abnormality of sulfur amino acid metabolism (HP:0004339)1.82574366
91Gangrene (HP:0100758)1.82192437
92Increased serum ferritin (HP:0003281)1.80830931
93Agammaglobulinemia (HP:0004432)1.80794030
94Progressive neurologic deterioration (HP:0002344)1.80646898
95Recurrent gram-negative bacterial infections (HP:0005420)1.80618418
96Vasculitis (HP:0002633)1.80304821
97Gingival bleeding (HP:0000225)1.80237447
98Hypothermia (HP:0002045)1.79810984
99Keratoconjunctivitis (HP:0001096)1.79535315
100Tetany (HP:0001281)1.79311467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.42024519
2VRK23.49723427
3MAP3K123.04571503
4ZAK3.02748219
5BUB12.62038764
6TXK2.56179993
7VRK12.46702325
8STK162.41845032
9TESK22.34467262
10NUAK12.20191685
11BCKDK2.08348065
12TAOK32.07976737
13NME21.79084460
14KIT1.66924533
15TNK21.63928368
16MAP4K11.61258342
17EIF2AK31.48910272
18KDR1.39261861
19TLK11.36981260
20BLK1.36894825
21BMPR21.33181903
22IKBKB1.31324536
23SCYL21.30904552
24IKBKE1.22995405
25IRAK41.21715303
26ADRBK21.21009301
27CDK191.20959243
28CSF1R1.19179149
29PIK3CG1.17669229
30MAP4K21.17470978
31FES1.17046287
32SIK31.16803909
33GRK11.15074288
34DAPK11.15036732
35TRIM281.14956660
36FRK1.12881030
37INSRR1.12810312
38MAP3K111.12378873
39JAK31.12278625
40RIPK41.10121939
41PBK1.06627688
42LYN1.04888411
43OXSR11.02001620
44GRK61.01869608
45SYK0.99786216
46PLK30.99149374
47PDK20.94069680
48NME10.91960302
49FLT30.88044769
50BTK0.86859359
51ZAP700.83841159
52MATK0.83006131
53TAF10.82838845
54PLK40.82328774
55TYK20.82175027
56WNK30.79841493
57MAP2K60.77835226
58MAP2K30.77740571
59TBK10.74244940
60TESK10.74242575
61EIF2AK10.74129054
62CSNK1G30.74111631
63PRKCQ0.71375153
64MAP3K30.70410722
65CSK0.69274450
66TEC0.68332071
67PIM20.67677830
68RPS6KA50.67101880
69MARK30.66570366
70MAP3K50.65554707
71LCK0.64119892
72ILK0.63208237
73DYRK20.61185154
74PIM10.60284276
75TSSK60.60266889
76IRAK30.59626464
77MAPKAPK30.58685594
78RPS6KB20.58470276
79HCK0.57499298
80BRSK20.57219385
81ITK0.56608364
82NEK10.55566075
83ABL20.52086133
84MYLK0.51394074
85CDC70.50180291
86DYRK30.49099542
87IRAK10.48689825
88CSNK1G10.48475324
89TRPM70.48069982
90PRKG20.44842577
91CSNK2A10.44631049
92CSNK1G20.44157575
93DAPK30.43877014
94PINK10.43445294
95PLK10.42739655
96LRRK20.42135693
97ATR0.42120374
98AURKA0.41958200
99STK100.41449277
100JAK20.41014446

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.14108788
2Oxidative phosphorylation_Homo sapiens_hsa001903.13853987
3Parkinsons disease_Homo sapiens_hsa050122.59230481
4Ribosome_Homo sapiens_hsa030102.21115759
5RNA polymerase_Homo sapiens_hsa030202.14799582
6Graft-versus-host disease_Homo sapiens_hsa053322.07615554
7* One carbon pool by folate_Homo sapiens_hsa006702.02204758
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.90731392
9Protein export_Homo sapiens_hsa030601.89014276
10Allograft rejection_Homo sapiens_hsa053301.81683244
11Asthma_Homo sapiens_hsa053101.80121322
12Homologous recombination_Homo sapiens_hsa034401.77520735
13Primary immunodeficiency_Homo sapiens_hsa053401.76115134
14Type I diabetes mellitus_Homo sapiens_hsa049401.73379314
15Autoimmune thyroid disease_Homo sapiens_hsa053201.73055576
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.67643855
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62560101
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.59767925
19Mismatch repair_Homo sapiens_hsa034301.58131638
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48927192
21Alzheimers disease_Homo sapiens_hsa050101.46641138
22DNA replication_Homo sapiens_hsa030301.46420052
23Huntingtons disease_Homo sapiens_hsa050161.43993826
24Antigen processing and presentation_Homo sapiens_hsa046121.43531247
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43487481
26Peroxisome_Homo sapiens_hsa041461.40555207
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39763777
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37853463
29Staphylococcus aureus infection_Homo sapiens_hsa051501.37785365
30Fatty acid elongation_Homo sapiens_hsa000621.31899442
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30110463
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.29915830
33Pyrimidine metabolism_Homo sapiens_hsa002401.28672767
34Rheumatoid arthritis_Homo sapiens_hsa053231.24630157
35Chemical carcinogenesis_Homo sapiens_hsa052041.23528953
36Base excision repair_Homo sapiens_hsa034101.23184141
37Propanoate metabolism_Homo sapiens_hsa006401.20047855
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19045995
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18802018
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.17294456
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15718765
42Retinol metabolism_Homo sapiens_hsa008301.15625310
43Glutathione metabolism_Homo sapiens_hsa004801.15391339
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14565902
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.14130975
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10765361
47Sulfur metabolism_Homo sapiens_hsa009201.09432362
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08208075
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06336621
50Butanoate metabolism_Homo sapiens_hsa006501.05554109
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05107568
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03879573
53Selenocompound metabolism_Homo sapiens_hsa004501.02177976
54Leishmaniasis_Homo sapiens_hsa051400.98322321
55Collecting duct acid secretion_Homo sapiens_hsa049660.98106386
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.97094611
57Caffeine metabolism_Homo sapiens_hsa002320.96605386
58RNA degradation_Homo sapiens_hsa030180.93969762
59Vitamin B6 metabolism_Homo sapiens_hsa007500.92431360
60Arachidonic acid metabolism_Homo sapiens_hsa005900.91528087
61Nucleotide excision repair_Homo sapiens_hsa034200.88957395
62Tryptophan metabolism_Homo sapiens_hsa003800.88843837
63Linoleic acid metabolism_Homo sapiens_hsa005910.88334092
64Non-homologous end-joining_Homo sapiens_hsa034500.87990259
65Hematopoietic cell lineage_Homo sapiens_hsa046400.85701483
66Purine metabolism_Homo sapiens_hsa002300.85026161
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83960714
68Spliceosome_Homo sapiens_hsa030400.83357952
69RNA transport_Homo sapiens_hsa030130.81362629
70Folate biosynthesis_Homo sapiens_hsa007900.78816455
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.76896828
72Complement and coagulation cascades_Homo sapiens_hsa046100.74439244
73* Metabolic pathways_Homo sapiens_hsa011000.73841441
74beta-Alanine metabolism_Homo sapiens_hsa004100.73162559
75Legionellosis_Homo sapiens_hsa051340.72140380
76Basal transcription factors_Homo sapiens_hsa030220.68809219
77Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66129744
78Phototransduction_Homo sapiens_hsa047440.65225587
79Regulation of autophagy_Homo sapiens_hsa041400.64810177
80Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64783431
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62141985
82Systemic lupus erythematosus_Homo sapiens_hsa053220.61858402
83Fatty acid degradation_Homo sapiens_hsa000710.61419144
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.60366112
85Herpes simplex infection_Homo sapiens_hsa051680.59125879
86Fanconi anemia pathway_Homo sapiens_hsa034600.58269879
87Pyruvate metabolism_Homo sapiens_hsa006200.57950636
88Tuberculosis_Homo sapiens_hsa051520.57217690
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56235397
90Measles_Homo sapiens_hsa051620.55671838
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55439286
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55432696
93Tyrosine metabolism_Homo sapiens_hsa003500.53926360
94Nitrogen metabolism_Homo sapiens_hsa009100.50691398
95Viral myocarditis_Homo sapiens_hsa054160.49022404
96Epstein-Barr virus infection_Homo sapiens_hsa051690.48688329
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47362434
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47285232
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.47042005
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46743124

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