ST3GAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of interferon-alpha production (GO:0032727)4.35659881
2regulation of interferon-alpha production (GO:0032647)4.15110789
3complement activation, alternative pathway (GO:0006957)3.98843455
4triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.88883701
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87248593
6negative regulation of cell killing (GO:0031342)3.87248593
7aromatic amino acid family catabolic process (GO:0009074)3.80621440
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.79316768
9L-phenylalanine catabolic process (GO:0006559)3.79316768
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.79218697
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.79218697
12indole-containing compound catabolic process (GO:0042436)3.79056480
13indolalkylamine catabolic process (GO:0046218)3.79056480
14tryptophan catabolic process (GO:0006569)3.79056480
15positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.73673604
16protein carboxylation (GO:0018214)3.72410108
17peptidyl-glutamic acid carboxylation (GO:0017187)3.72410108
18regulation of protein activation cascade (GO:2000257)3.66137616
19negative regulation of fibrinolysis (GO:0051918)3.65185899
20response to peptidoglycan (GO:0032494)3.59681405
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.57653772
22L-phenylalanine metabolic process (GO:0006558)3.57653772
23antigen processing and presentation of endogenous antigen (GO:0019883)3.57107830
24kynurenine metabolic process (GO:0070189)3.56106687
25alpha-linolenic acid metabolic process (GO:0036109)3.54117995
26tryptophan metabolic process (GO:0006568)3.52236316
27regulation of complement activation (GO:0030449)3.44728406
28plasma lipoprotein particle clearance (GO:0034381)3.41137874
29urea metabolic process (GO:0019627)3.40322141
30urea cycle (GO:0000050)3.40322141
31positive regulation of gamma-delta T cell activation (GO:0046645)3.36560496
32regulation of fibrinolysis (GO:0051917)3.36459170
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.28317225
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.27891968
35high-density lipoprotein particle remodeling (GO:0034375)3.20752123
36neutrophil activation involved in immune response (GO:0002283)3.16652186
37phospholipid efflux (GO:0033700)3.14635869
38cellular extravasation (GO:0045123)3.13821448
39regulation of triglyceride catabolic process (GO:0010896)3.13222249
40protein localization to endosome (GO:0036010)3.11477788
41bile acid biosynthetic process (GO:0006699)3.11285940
42acute-phase response (GO:0006953)3.08089417
43negative regulation of interleukin-12 production (GO:0032695)3.04489132
44low-density lipoprotein particle clearance (GO:0034383)3.03384324
45nitrogen cycle metabolic process (GO:0071941)3.02227926
46regulation of RIG-I signaling pathway (GO:0039535)2.99280695
47fibrinolysis (GO:0042730)2.93845141
48cysteine metabolic process (GO:0006534)2.92662315
49regulation of cholesterol storage (GO:0010885)2.92484883
50negative regulation of bone mineralization (GO:0030502)2.91225389
51negative regulation of cholesterol transport (GO:0032375)2.90727706
52negative regulation of sterol transport (GO:0032372)2.90727706
53reverse cholesterol transport (GO:0043691)2.89813053
54macrophage activation involved in immune response (GO:0002281)2.88386743
55glyoxylate metabolic process (GO:0046487)2.87089438
56positive regulation of blood coagulation (GO:0030194)2.85500405
57positive regulation of hemostasis (GO:1900048)2.85500405
58lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84720947
59plasma lipoprotein particle assembly (GO:0034377)2.84647171
60phospholipid homeostasis (GO:0055091)2.82153357
61positive regulation of coagulation (GO:0050820)2.81508050
62positive regulation of lipid catabolic process (GO:0050996)2.80396668
63response to muramyl dipeptide (GO:0032495)2.79922881
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79784462
65positive regulation by organism of defense response of other organism involved in symbiotic interact2.79784462
66modulation by symbiont of host immune response (GO:0052553)2.79784462
67positive regulation by symbiont of host defense response (GO:0052509)2.79784462
68modulation by symbiont of host defense response (GO:0052031)2.79784462
69modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79784462
70detection of other organism (GO:0098543)2.79264513
71CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.78814781
72positive regulation of interferon-beta production (GO:0032728)2.77974320
73detection of molecule of bacterial origin (GO:0032490)2.77414070
74regulation of cholesterol homeostasis (GO:2000188)2.76291544
75protein-lipid complex remodeling (GO:0034368)2.75124165
76macromolecular complex remodeling (GO:0034367)2.75124165
77plasma lipoprotein particle remodeling (GO:0034369)2.75124165
78regulation of cholesterol esterification (GO:0010872)2.73658051
79regulation of heterotypic cell-cell adhesion (GO:0034114)2.72357035
80regulation of humoral immune response (GO:0002920)2.72020369
81leukocyte aggregation (GO:0070486)2.71933154
82sulfur amino acid catabolic process (GO:0000098)2.71619341
83protein-lipid complex assembly (GO:0065005)2.70689017
84cholesterol efflux (GO:0033344)2.70329134
85protein activation cascade (GO:0072376)2.70155578
86acylglycerol homeostasis (GO:0055090)2.67552970
87triglyceride homeostasis (GO:0070328)2.67552970
88negative regulation of myeloid cell apoptotic process (GO:0033033)2.67149947
89complement activation (GO:0006956)2.66295523
90positive regulation of humoral immune response (GO:0002922)2.66143670
91mannose metabolic process (GO:0006013)2.65928215
92regulation of gamma-delta T cell differentiation (GO:0045586)2.65886120
93iron ion import (GO:0097286)2.63878602
94negative regulation of lipase activity (GO:0060192)2.63360203
95complement activation, classical pathway (GO:0006958)2.62710782
96germinal center formation (GO:0002467)2.61843653
97bile acid metabolic process (GO:0008206)2.60140594
98regulation of B cell receptor signaling pathway (GO:0050855)2.59936583
99negative regulation of biomineral tissue development (GO:0070168)2.59836288
100regulation of gamma-delta T cell activation (GO:0046643)2.58212373
101cellular response to virus (GO:0098586)2.58077242
102detection of external biotic stimulus (GO:0098581)2.57993337
103detection of bacterium (GO:0016045)2.57871132
104blood coagulation, intrinsic pathway (GO:0007597)2.57766693
105regulation of interleukin-12 biosynthetic process (GO:0045075)2.57217710
106neutrophil activation (GO:0042119)2.56483466
107positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54995676
108positive thymic T cell selection (GO:0045059)2.54173241
109positive regulation of bone resorption (GO:0045780)2.54103730
110positive regulation of bone remodeling (GO:0046852)2.54103730
111granulocyte activation (GO:0036230)2.54072085
112regulation of leukocyte degranulation (GO:0043300)2.54050844
113negative regulation of erythrocyte differentiation (GO:0045647)2.53069219
114aromatic amino acid family metabolic process (GO:0009072)2.51905808
115cellular response to thyroid hormone stimulus (GO:0097067)2.50821946
116regulation of interferon-beta biosynthetic process (GO:0045357)2.50740819
117response to laminar fluid shear stress (GO:0034616)2.50181483
118regulation of mast cell degranulation (GO:0043304)2.49434890
119cellular response to ethanol (GO:0071361)2.48702122
120indolalkylamine metabolic process (GO:0006586)2.48517957
121amino-acid betaine metabolic process (GO:0006577)2.48192661
122homocysteine metabolic process (GO:0050667)2.44965727
123negative regulation of lipid storage (GO:0010888)2.44752457
124regulation of T-helper 2 cell differentiation (GO:0045628)2.43919286
125positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.42528175
126positive regulation of lipid storage (GO:0010884)2.41867450
127positive regulation of lipoprotein lipase activity (GO:0051006)2.41704205
128positive regulation of triglyceride lipase activity (GO:0061365)2.41704205
129response to type I interferon (GO:0034340)2.41462522
130regulation of myeloid leukocyte mediated immunity (GO:0002886)2.41459684
131regulation of necroptotic process (GO:0060544)2.41222294
132negative thymic T cell selection (GO:0045060)2.37628833
133negative regulation of cytokine production involved in immune response (GO:0002719)2.37258531
134positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.37219068
135pinocytosis (GO:0006907)2.36524026
136regulation of dendritic cell antigen processing and presentation (GO:0002604)2.33919443
137regulation of T cell tolerance induction (GO:0002664)2.32794825
138negative T cell selection (GO:0043383)2.30694214
139cellular response to type I interferon (GO:0071357)2.30619677
140type I interferon signaling pathway (GO:0060337)2.30619677
141T cell migration (GO:0072678)2.27952763
142response to thyroid hormone (GO:0097066)2.27004594
143negative regulation of T cell mediated immunity (GO:0002710)2.24984785
144regulation of mast cell activation involved in immune response (GO:0033006)2.23953417
145negative regulation of lymphocyte mediated immunity (GO:0002707)2.23254077
146negative regulation of leukocyte mediated immunity (GO:0002704)2.22760839
147production of molecular mediator involved in inflammatory response (GO:0002532)2.22747453
148macrophage activation (GO:0042116)2.22521850
149thymic T cell selection (GO:0045061)2.21903144
150positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.21876431
151detection of biotic stimulus (GO:0009595)2.20563998
152negative regulation of innate immune response (GO:0045824)2.19703635
153T cell selection (GO:0045058)2.17997111
154positive T cell selection (GO:0043368)2.17486855
155tolerance induction (GO:0002507)2.17418762
156response to interleukin-15 (GO:0070672)2.17015740
157positive regulation of receptor recycling (GO:0001921)2.16693281
158interferon-gamma secretion (GO:0072643)2.15932033
159regulation of tolerance induction (GO:0002643)2.15923906
160response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.15439499
161response to host (GO:0075136)2.15439499
162response to host defenses (GO:0052200)2.15439499
163positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.15340098
164positive regulation of cholesterol efflux (GO:0010875)2.14576338
165positive regulation of cellular amide metabolic process (GO:0034250)2.13792680
166positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.13020764
167hepatocyte apoptotic process (GO:0097284)2.12103971
168positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.11931625
169positive regulation of type 2 immune response (GO:0002830)2.11662050
170regulation of membrane protein ectodomain proteolysis (GO:0051043)2.11291643
171regulation of type I interferon-mediated signaling pathway (GO:0060338)2.10642223
172positive regulation of extracellular matrix organization (GO:1903055)2.10496719
173defense response to protozoan (GO:0042832)2.10101173
174immunoglobulin mediated immune response (GO:0016064)2.08985199
175myeloid cell activation involved in immune response (GO:0002275)2.08270224
176regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.08053735
177NIK/NF-kappaB signaling (GO:0038061)2.06792595
178regulation of response to interferon-gamma (GO:0060330)2.06293421
179JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.06191648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.19512700
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.25634607
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.46259964
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.32736354
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.89278688
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.65546215
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.40820955
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.23531666
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.22301576
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.21428650
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.92208528
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.90315504
13* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.81193184
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56213340
15* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.48807658
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.46445852
17* IRF8_27001747_Chip-Seq_BMDM_Mouse2.44980208
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43841703
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.36430709
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33318678
21* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32050063
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31396922
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29361859
24* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16858630
25* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14706764
26* SCL_19346495_ChIP-Seq_HPC-7_Human2.08218019
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.07603968
28SMAD_19615063_ChIP-ChIP_OVARY_Human2.02327499
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.00883221
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99898284
31GATA1_22025678_ChIP-Seq_K562_Human1.91229403
32RUNX_20019798_ChIP-Seq_JUKART_Human1.89597302
33* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.79370552
34CLOCK_20551151_ChIP-Seq_293T_Human1.75071840
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.66221095
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63416775
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62321247
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59871857
39* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58630277
40* MAF_26560356_Chip-Seq_TH1_Human1.54105073
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47351534
42* VDR_24763502_ChIP-Seq_THP-1_Human1.47141320
43RACK7_27058665_Chip-Seq_MCF-7_Human1.46429104
44MYC_22102868_ChIP-Seq_BL_Human1.46020621
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44668982
46* TCF7_22412390_ChIP-Seq_EML_Mouse1.42033511
47* GATA1_19941826_ChIP-Seq_K562_Human1.41332918
48* VDR_24787735_ChIP-Seq_THP-1_Human1.40737813
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40132111
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39915613
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39822737
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39237414
53* VDR_21846776_ChIP-Seq_THP-1_Human1.38430285
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32636311
55* ELK3_25401928_ChIP-Seq_HUVEC_Human1.32459144
56* GATA1_19941827_ChIP-Seq_MEL_Mouse1.31384043
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30465203
58TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.30367502
59TP63_17297297_ChIP-ChIP_HaCaT_Human1.28600213
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28529639
61* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25427890
62* GATA2_19941826_ChIP-Seq_K562_Human1.25194461
63* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25106662
64UTX_26944678_Chip-Seq_JUKART_Human1.24892320
65* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22393719
66* MYB_26560356_Chip-Seq_TH2_Human1.21339518
67* MAF_26560356_Chip-Seq_TH2_Human1.20420282
68* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20395041
69E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20388255
70TBX20_22080862_ChIP-Seq_HEART_Mouse1.19810683
71TBX20_22328084_ChIP-Seq_HEART_Mouse1.19810683
72* FOXA2_19822575_ChIP-Seq_HepG2_Human1.18870164
73* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18723380
74* KDM2B_26808549_Chip-Seq_JURKAT_Human1.18123345
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18056542
76* MYB_26560356_Chip-Seq_TH1_Human1.17019360
77* PU_27001747_Chip-Seq_BMDM_Mouse1.16777428
78SPI1_23127762_ChIP-Seq_K562_Human1.16319499
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15506655
80KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15211690
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14105826
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09823914
83* RUNX1_22412390_ChIP-Seq_EML_Mouse1.07529264
84SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07090951
85* ESR2_21235772_ChIP-Seq_MCF-7_Human1.06698826
86EGR1_19032775_ChIP-ChIP_M12_Human1.05492412
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04412342
88KDM2B_26808549_Chip-Seq_DND41_Human1.04340197
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03337596
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02936669
91* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02122953
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.01155158
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00009854
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95435607
95* LXR_22292898_ChIP-Seq_THP-1_Human0.93916603
96* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93349919
97* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92471766
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92329861
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90014275
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.88012323
101* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87563351
102* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87005778
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85953443
104GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85015487
105* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85006040
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.84846401
107CDX2_20551321_ChIP-Seq_CACO-2_Human0.83224267
108SPI1_23547873_ChIP-Seq_NB4_Human0.83171826
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82947640
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82410688
111NCOR1_26117541_ChIP-Seq_K562_Human0.82126738
112LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81740971
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81217514
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80742916
115* ESR1_21235772_ChIP-Seq_MCF-7_Human0.79328407
116* SOX2_20726797_ChIP-Seq_SW620_Human0.79217254
117NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78552577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.46938138
2MP0005360_urolithiasis3.86873587
3MP0005085_abnormal_gallbladder_physiolo3.14352665
4MP0005451_abnormal_body_composition3.10257712
5MP0005365_abnormal_bile_salt3.04133579
6MP0009840_abnormal_foam_cell2.62149780
7MP0003436_decreased_susceptibility_to2.61470251
8MP0003303_peritoneal_inflammation2.47012812
9MP0001835_abnormal_antigen_presentation2.42973529
10MP0008875_abnormal_xenobiotic_pharmacok2.34823328
11MP0003724_increased_susceptibility_to2.34415616
12MP0002138_abnormal_hepatobiliary_system2.29616748
13MP0003191_abnormal_cellular_cholesterol2.27973187
14MP0005083_abnormal_biliary_tract2.23486686
15MP0009785_altered_susceptibility_to2.22225342
16MP0003252_abnormal_bile_duct2.18303805
17MP0010329_abnormal_lipoprotein_level2.14279740
18MP0000685_abnormal_immune_system2.03729967
19MP0001790_abnormal_immune_system1.99491862
20MP0005387_immune_system_phenotype1.99491862
21MP0004510_myositis1.96093161
22MP0005464_abnormal_platelet_physiology1.91155878
23MP0002419_abnormal_innate_immunity1.88788712
24MP0003828_pulmonary_edema1.87666942
25MP0010368_abnormal_lymphatic_system1.82766826
26MP0005025_abnormal_response_to1.80469539
27MP0003172_abnormal_lysosome_physiology1.73607635
28MP0005000_abnormal_immune_tolerance1.72622168
29MP0003300_gastrointestinal_ulcer1.72368332
30MP0001800_abnormal_humoral_immune1.70673385
31MP0009764_decreased_sensitivity_to1.69795963
32MP0000609_abnormal_liver_physiology1.64919587
33MP0006082_CNS_inflammation1.64357324
34MP0003705_abnormal_hypodermis_morpholog1.62571785
35MP0001348_abnormal_lacrimal_gland1.60804320
36MP0002452_abnormal_antigen_presenting1.59963140
37MP0002148_abnormal_hypersensitivity_rea1.57365685
38MP0005671_abnormal_response_to1.55202769
39MP0004947_skin_inflammation1.55180395
40MP0003656_abnormal_erythrocyte_physiolo1.53340782
41MP0002723_abnormal_immune_serum1.49087949
42MP0008469_abnormal_protein_level1.48103565
43MP0002933_joint_inflammation1.47865946
44MP0008260_abnormal_autophagy1.45374218
45MP0000858_altered_metastatic_potential1.45321384
46MP0003806_abnormal_nucleotide_metabolis1.45012183
47MP0001533_abnormal_skeleton_physiology1.44338941
48MP0002998_abnormal_bone_remodeling1.36041591
49MP0003195_calcinosis1.35091386
50MP0008004_abnormal_stomach_pH1.35010079
51MP0005319_abnormal_enzyme/_coenzyme1.34269885
52MP0002166_altered_tumor_susceptibility1.33745320
53MP0002254_reproductive_system_inflammat1.33145588
54MP0001845_abnormal_inflammatory_respons1.32491057
55MP0005332_abnormal_amino_acid1.32200068
56MP0002332_abnormal_exercise_endurance1.31729950
57MP0002118_abnormal_lipid_homeostasis1.27856600
58MP0001819_abnormal_immune_cell1.27686687
59MP0001853_heart_inflammation1.26796247
60MP0002420_abnormal_adaptive_immunity1.25720971
61MP0009333_abnormal_splenocyte_physiolog1.25585091
62MP0004233_abnormal_muscle_weight1.24448585
63MP0001851_eye_inflammation1.22307791
64MP0009278_abnormal_bone_marrow1.21563213
65MP0005310_abnormal_salivary_gland1.20642950
66MP0010155_abnormal_intestine_physiology1.18176863
67MP0009763_increased_sensitivity_to1.17638420
68MP0001545_abnormal_hematopoietic_system1.14949156
69MP0005397_hematopoietic_system_phenotyp1.14949156
70MP0005058_abnormal_lysosome_morphology1.14053777
71MP0000604_amyloidosis1.13814935
72MP0001666_abnormal_nutrient_absorption1.13743457
73MP0001879_abnormal_lymphatic_vessel1.13020044
74MP0000343_altered_response_to1.12818874
75MP0003279_aneurysm1.12410523
76MP0005408_hypopigmentation1.11393597
77MP0002405_respiratory_system_inflammati1.09046390
78MP0004782_abnormal_surfactant_physiolog1.08462542
79MP0005167_abnormal_blood-brain_barrier1.08371230
80MP0002006_tumorigenesis1.07611145
81MP0004019_abnormal_vitamin_homeostasis1.05766131
82MP0000716_abnormal_immune_system1.05740911
83MP0000689_abnormal_spleen_morphology1.05473457
84MP0000598_abnormal_liver_morphology1.04726069
85MP0005023_abnormal_wound_healing1.04684648
86MP0005076_abnormal_cell_differentiation1.04384534
87MP0004036_abnormal_muscle_relaxation1.03594025
88MP0002398_abnormal_bone_marrow1.01923995
89MP0003566_abnormal_cell_adhesion1.01622635
90MP0004883_abnormal_blood_vessel1.00624851
91MP0003075_altered_response_to0.99884114
92MP0003690_abnormal_glial_cell0.97526353
93MP0004858_abnormal_nervous_system0.96180949
94MP0003448_altered_tumor_morphology0.95678728
95MP0004381_abnormal_hair_follicle0.95532718
96MP0005165_increased_susceptibility_to0.95251935
97MP0000249_abnormal_blood_vessel0.94606401
98MP0004130_abnormal_muscle_cell0.94190166
99MP0005584_abnormal_enzyme/coenzyme_acti0.93185012
100MP0000751_myopathy0.92868638
101MP0005166_decreased_susceptibility_to0.92486576
102MP0003763_abnormal_thymus_physiology0.91497823
103MP0002722_abnormal_immune_system0.90718179
104MP0003045_fibrosis0.89632131
105MP0000767_abnormal_smooth_muscle0.89389355
106MP0004185_abnormal_adipocyte_glucose0.89235553
107MP0004084_abnormal_cardiac_muscle0.89121969
108MP0005075_abnormal_melanosome_morpholog0.88935876
109MP0009643_abnormal_urine_homeostasis0.88683214
110MP0005666_abnormal_adipose_tissue0.88647238
111MP0003868_abnormal_feces_composition0.86938166
112MP0005670_abnormal_white_adipose0.86002247
113MP0002429_abnormal_blood_cell0.85460666
114MP0003329_amyloid_beta_deposits0.83888084
115MP0004808_abnormal_hematopoietic_stem0.83186107
116MP0005164_abnormal_response_to0.82506685
117MP0000465_gastrointestinal_hemorrhage0.82071371
118MP0009697_abnormal_copulation0.81705307
119MP0001958_emphysema0.81497389
120MP0004484_altered_response_of0.81451794
121MP0005390_skeleton_phenotype0.80745226
122MP0002136_abnormal_kidney_physiology0.80138361
123MP0002877_abnormal_melanocyte_morpholog0.77702303
124MP0003453_abnormal_keratinocyte_physiol0.77171926
125MP0008438_abnormal_cutaneous_collagen0.76521724
126MP0003221_abnormal_cardiomyocyte_apopto0.76332998
127MP0001873_stomach_inflammation0.73573158
128MP0003091_abnormal_cell_migration0.72858444

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.26224309
2Complement deficiency (HP:0004431)4.16588181
3Joint hemorrhage (HP:0005261)4.08731183
4Xanthomatosis (HP:0000991)4.01116731
5Recurrent gram-negative bacterial infections (HP:0005420)3.92047198
6Prolonged partial thromboplastin time (HP:0003645)3.88331314
7Intrahepatic cholestasis (HP:0001406)3.87927225
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.70381399
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.68940912
10Abnormality of glycolipid metabolism (HP:0010969)3.68724006
11Abnormality of liposaccharide metabolism (HP:0010968)3.68724006
12Abnormality of glycosphingolipid metabolism (HP:0004343)3.68724006
13Abnormality of the common coagulation pathway (HP:0010990)3.63183661
14Myocardial infarction (HP:0001658)3.62413838
15Hyperlipoproteinemia (HP:0010980)3.43927693
16Gingival bleeding (HP:0000225)3.41041957
17Mitral stenosis (HP:0001718)3.30846632
18Systemic lupus erythematosus (HP:0002725)3.23588261
19Abnormality of complement system (HP:0005339)3.22953183
20Eczematoid dermatitis (HP:0000976)3.16809641
21Dysostosis multiplex (HP:0000943)3.09523202
22Glomerulonephritis (HP:0000099)3.04680695
23Mediastinal lymphadenopathy (HP:0100721)2.99392358
24Asymmetric septal hypertrophy (HP:0001670)2.97985377
25Interstitial pulmonary disease (HP:0006530)2.96750644
26Spontaneous hematomas (HP:0007420)2.96470558
27Esophageal varix (HP:0002040)2.94900684
28Epidermoid cyst (HP:0200040)2.91351834
29Autoimmune thrombocytopenia (HP:0001973)2.91006272
30Hypobetalipoproteinemia (HP:0003563)2.90457845
31Menorrhagia (HP:0000132)2.89240802
32Recurrent bacterial skin infections (HP:0005406)2.88430908
33Loss of speech (HP:0002371)2.74810835
34Recurrent abscess formation (HP:0002722)2.71051608
35Urinary glycosaminoglycan excretion (HP:0003541)2.69356680
36Mucopolysacchariduria (HP:0008155)2.69356680
37Nephritis (HP:0000123)2.69032552
38Vascular calcification (HP:0004934)2.68730916
39Epistaxis (HP:0000421)2.67783262
40Abnormality of mucopolysaccharide metabolism (HP:0011020)2.66453118
41Abnormality of polysaccharide metabolism (HP:0011012)2.66453118
42Abnormality of glycosaminoglycan metabolism (HP:0004371)2.66453118
43Retrobulbar optic neuritis (HP:0100654)2.64550534
44Optic neuritis (HP:0100653)2.64550534
45Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62011012
46Hypoalphalipoproteinemia (HP:0003233)2.61418045
47Hypercholesterolemia (HP:0003124)2.60761286
48Polycythemia (HP:0001901)2.56316236
49Hypolipoproteinemia (HP:0010981)2.51962935
50Elevated erythrocyte sedimentation rate (HP:0003565)2.51496872
51Pulmonary embolism (HP:0002204)2.50906407
52Cardiovascular calcification (HP:0011915)2.50530030
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.50261837
54Thrombophlebitis (HP:0004418)2.49333707
55Amyloidosis (HP:0011034)2.46935822
56Vasculitis (HP:0002633)2.44409893
57Abnormality of the intrinsic pathway (HP:0010989)2.42186526
58Myositis (HP:0100614)2.41350015
59Prolonged bleeding time (HP:0003010)2.37341767
60Joint swelling (HP:0001386)2.36590048
61Chronic otitis media (HP:0000389)2.35578081
62T lymphocytopenia (HP:0005403)2.33142758
63Peritonitis (HP:0002586)2.32175821
64Distal lower limb muscle weakness (HP:0009053)2.32106606
65Periodontitis (HP:0000704)2.31848350
66Spondylolisthesis (HP:0003302)2.31466056
67Hepatocellular carcinoma (HP:0001402)2.29956926
68Spontaneous abortion (HP:0005268)2.29669825
69Vacuolated lymphocytes (HP:0001922)2.28117560
70Orchitis (HP:0100796)2.28053249
71Abnormal platelet volume (HP:0011876)2.26500775
72Abnormal platelet function (HP:0011869)2.25328564
73Impaired platelet aggregation (HP:0003540)2.25328564
74Gastrointestinal infarctions (HP:0005244)2.23426313
75Vertebral compression fractures (HP:0002953)2.22915743
76Abnormality of the peritoneum (HP:0002585)2.22480315
77Abnormality of sulfur amino acid metabolism (HP:0004339)2.21821284
78Cellulitis (HP:0100658)2.21563699
79Recurrent skin infections (HP:0001581)2.21077594
80Purpura (HP:0000979)2.20426202
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.19879432
82Abnormality of iron homeostasis (HP:0011031)2.19339401
83Hematochezia (HP:0002573)2.18695229
84Arterial thrombosis (HP:0004420)2.18651986
85Axonal loss (HP:0003447)2.18591205
86Recurrent fungal infections (HP:0002841)2.18357360
87Recurrent viral infections (HP:0004429)2.16012226
88Pustule (HP:0200039)2.15945744
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.15314197
90Hemorrhage of the eye (HP:0011885)2.14915103
91Increased serum ferritin (HP:0003281)2.14085777
92Exercise-induced myalgia (HP:0003738)2.13943732
93Increased mean platelet volume (HP:0011877)2.10646084
94Hyporeflexia of lower limbs (HP:0002600)2.10603242
95Abnormality of macrophages (HP:0004311)2.08252495
96Increased connective tissue (HP:0009025)2.08007993
97Hyperammonemia (HP:0001987)2.07194301
98Abnormality of the nasal mucosa (HP:0000433)2.06355988
99Fat malabsorption (HP:0002630)2.05676322
100Abnormality of T cell number (HP:0011839)2.05639640
101Meningitis (HP:0001287)2.05053687
102Microcytic anemia (HP:0001935)2.03058703
103Osteolytic defects of the hand bones (HP:0009699)2.00804823
104Osteolytic defects of the phalanges of the hand (HP:0009771)2.00804823
105Stomatitis (HP:0010280)1.99507281
106Hypoglycemic coma (HP:0001325)1.98539090
107Hyperbilirubinemia (HP:0002904)1.95569392
108Chest pain (HP:0100749)1.95524642
109Abnormality of transition element cation homeostasis (HP:0011030)1.95487394
110Obstructive lung disease (HP:0006536)1.95018480
111Chronic obstructive pulmonary disease (HP:0006510)1.95018480
112Pulmonary infiltrates (HP:0002113)1.94638592
113Increased cerebral lipofuscin (HP:0011813)1.92884488
114Urticaria (HP:0001025)1.89700930
115Neurofibrillary tangles (HP:0002185)1.89362073
116Skin nodule (HP:0200036)1.89170050
117Abnormality of purine metabolism (HP:0004352)1.88917822
118Acanthocytosis (HP:0001927)1.88721734
119Aneurysm (HP:0002617)1.88567653
120Cerebral inclusion bodies (HP:0100314)1.88245183
121Ketosis (HP:0001946)1.87425286
122Late onset (HP:0003584)1.86843146
123Hemoptysis (HP:0002105)1.86346225
124Tetraparesis (HP:0002273)1.85055596
125Subacute progressive viral hepatitis (HP:0006572)1.84274622
126Poikilocytosis (HP:0004447)1.83418155
127Gingivitis (HP:0000230)1.83330229
128Slow saccadic eye movements (HP:0000514)1.82277727
129Colitis (HP:0002583)1.81515372
130Abnormality of methionine metabolism (HP:0010901)1.80391942
131Abnormality of nucleobase metabolism (HP:0010932)1.79456342
132Protrusio acetabuli (HP:0003179)1.79252376
133Inflammation of the large intestine (HP:0002037)1.79123905
134Cerebral aneurysm (HP:0004944)1.77494687
135Recurrent cutaneous fungal infections (HP:0011370)1.77052894
136Chronic mucocutaneous candidiasis (HP:0002728)1.77052894
137Abnormality of skeletal muscle fiber size (HP:0012084)1.76666535
138Distal lower limb amyotrophy (HP:0008944)1.76347309
139Thoracic kyphosis (HP:0002942)1.76116879
140Autoimmune hemolytic anemia (HP:0001890)1.75934097
141Spinal cord lesions (HP:0100561)1.75732201
142Gastrointestinal inflammation (HP:0004386)1.75375252
143Neonatal hypoglycemia (HP:0001998)1.75081343
144Cervical subluxation (HP:0003308)1.74838217
145Thin bony cortex (HP:0002753)1.73894479
146Keratoconjunctivitis sicca (HP:0001097)1.72333007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.95730187
2MAP4K13.14026146
3FGFR42.79496574
4PRPF4B2.77614308
5TRIB32.72441833
6MAP3K142.67558021
7TYK22.66779307
8TBK12.49456383
9TGFBR22.38860573
10SIK12.37347183
11JAK32.16248922
12TAOK32.09783111
13PKN22.05890229
14JAK11.98947357
15KIT1.90926143
16AKT31.82862026
17IRAK31.81137596
18IKBKE1.79218327
19TIE11.77579228
20BLK1.74487022
21MAP3K101.68457455
22EPHB11.61720552
23ZAP701.57081147
24NEK91.50285520
25CSK1.48709980
26ICK1.43759259
27IKBKB1.41816817
28FGFR31.41762783
29EPHA21.40504488
30CAMK1D1.39245909
31PTK61.38527470
32JAK21.37192931
33TXK1.36674796
34LMTK21.35481101
35HCK1.31585442
36PRKD31.25953888
37LRRK21.25176463
38BCKDK1.25062199
39CHUK1.24603877
40CDK61.24565322
41IRAK41.24531054
42KDR1.24201800
43MAP2K31.24042589
44EPHA31.21580507
45TNK21.21421853
46MAP3K131.19472930
47CDC42BPA1.19449222
48RIPK11.19175538
49STK101.18548560
50SYK1.18181322
51TAOK21.18132796
52BMX1.16810197
53TAOK11.15980268
54PRKD21.13549639
55CSF1R1.11710472
56BTK1.09797728
57TTN1.08301075
58MAP3K71.02338729
59PIM10.96819778
60MST1R0.96172745
61FGR0.95871053
62CAMK1G0.95497267
63GRK60.92654574
64GRK70.90332832
65RIPK40.87406060
66MAPK40.86208915
67PIK3CG0.85463050
68CAMKK20.83170541
69PDPK10.82384073
70FLT30.78159564
71MARK20.78122192
72MAP3K30.77872786
73RPS6KA40.77041558
74EEF2K0.76577820
75SMG10.76546998
76LCK0.76350606
77TGFBR10.75678558
78SIK20.75455124
79SCYL20.74207051
80LYN0.73688319
81TEC0.69623391
82PAK40.69312690
83MAPK110.69278344
84ITK0.68817878
85NME20.67806306
86STK380.67758782
87IRAK10.67562642
88STK30.66675166
89BMPR20.66305363
90KSR20.63630530
91MAPK70.63578591
92ABL20.63453746
93NLK0.63269756
94EGFR0.62030183
95ABL10.61528129
96PRKAA20.61105796
97CDK120.60756151
98OBSCN0.59958679
99IRAK20.59751427
100HIPK20.58965760
101DDR20.58690744
102MAP3K60.58669550
103DYRK1B0.58616887
104MYLK0.58432199
105MTOR0.58216746
106SGK30.57589625
107PDGFRB0.57515687
108PRKG20.57222874
109PRKCH0.57098689
110RPS6KC10.56543784
111RPS6KL10.56543784
112PDGFRA0.56275313
113FER0.54981498
114INSRR0.53507479
115MAP3K110.52436408
116FES0.52198588
117RPS6KA20.51322727
118PRKCQ0.50152082
119STK40.49661607
120TESK20.49576750
121MAPK120.49116360
122MUSK0.48600730
123PIM20.47500077
124MARK30.47317311
125MATK0.46053948
126MAP3K10.45700634
127YES10.45330528
128GSK3A0.44171166
129RET0.42353985
130CDK40.41971847
131LATS10.41709594
132TRPM70.41489402
133CDK90.38746544
134ERBB40.37716900
135PDK10.37509268
136SIK30.36764929

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.44266117
2Staphylococcus aureus infection_Homo sapiens_hsa051503.24196302
3Complement and coagulation cascades_Homo sapiens_hsa046103.05742852
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96477540
5Nitrogen metabolism_Homo sapiens_hsa009102.70825735
6Other glycan degradation_Homo sapiens_hsa005112.66536374
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44853904
8Arginine biosynthesis_Homo sapiens_hsa002202.38134690
9Caffeine metabolism_Homo sapiens_hsa002322.18607752
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14110803
11Tryptophan metabolism_Homo sapiens_hsa003801.96528138
12Leishmaniasis_Homo sapiens_hsa051401.73184534
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.70118833
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68286992
15Fatty acid degradation_Homo sapiens_hsa000711.67367654
16PPAR signaling pathway_Homo sapiens_hsa033201.63594883
17Osteoclast differentiation_Homo sapiens_hsa043801.44978162
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44532338
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40357691
20Malaria_Homo sapiens_hsa051441.37370267
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37013625
22Selenocompound metabolism_Homo sapiens_hsa004501.36050929
23Measles_Homo sapiens_hsa051621.27022709
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24783016
25ABC transporters_Homo sapiens_hsa020101.24036977
26Peroxisome_Homo sapiens_hsa041461.23226401
27Non-small cell lung cancer_Homo sapiens_hsa052231.21739659
28VEGF signaling pathway_Homo sapiens_hsa043701.21471298
29Histidine metabolism_Homo sapiens_hsa003401.20921526
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19811104
31B cell receptor signaling pathway_Homo sapiens_hsa046621.17145762
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.15958641
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15561636
34Chemical carcinogenesis_Homo sapiens_hsa052041.12070334
35Retinol metabolism_Homo sapiens_hsa008301.11933836
36Pertussis_Homo sapiens_hsa051331.11332112
37Renal cell carcinoma_Homo sapiens_hsa052111.09645729
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07834177
39Toxoplasmosis_Homo sapiens_hsa051451.07139049
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05967765
41Pancreatic cancer_Homo sapiens_hsa052121.04634872
42Autoimmune thyroid disease_Homo sapiens_hsa053201.04571993
43TNF signaling pathway_Homo sapiens_hsa046681.02195054
44beta-Alanine metabolism_Homo sapiens_hsa004101.01701838
45Bile secretion_Homo sapiens_hsa049761.00484270
46Tuberculosis_Homo sapiens_hsa051520.99053300
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.98493349
48Fatty acid metabolism_Homo sapiens_hsa012120.98390519
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97534905
50Rheumatoid arthritis_Homo sapiens_hsa053230.97379938
51Starch and sucrose metabolism_Homo sapiens_hsa005000.96720400
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.96015716
53Lysine degradation_Homo sapiens_hsa003100.95405263
54Phenylalanine metabolism_Homo sapiens_hsa003600.93831692
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92509258
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.90796306
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90321475
58Hematopoietic cell lineage_Homo sapiens_hsa046400.90308838
59Endometrial cancer_Homo sapiens_hsa052130.89017381
60mTOR signaling pathway_Homo sapiens_hsa041500.88523105
61Graft-versus-host disease_Homo sapiens_hsa053320.88201581
62Legionellosis_Homo sapiens_hsa051340.87588251
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86831895
64Influenza A_Homo sapiens_hsa051640.84585931
65Insulin resistance_Homo sapiens_hsa049310.84096443
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.84094428
67Fat digestion and absorption_Homo sapiens_hsa049750.84040029
68Insulin signaling pathway_Homo sapiens_hsa049100.82226808
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81753393
70Herpes simplex infection_Homo sapiens_hsa051680.79990369
71Primary immunodeficiency_Homo sapiens_hsa053400.79086930
72Bladder cancer_Homo sapiens_hsa052190.78095978
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.77320057
74Small cell lung cancer_Homo sapiens_hsa052220.75833459
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75461958
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74993358
77Phagosome_Homo sapiens_hsa041450.74195721
78Hepatitis B_Homo sapiens_hsa051610.73374784
79Allograft rejection_Homo sapiens_hsa053300.72600029
80Acute myeloid leukemia_Homo sapiens_hsa052210.70994282
81Amoebiasis_Homo sapiens_hsa051460.70377428
82Shigellosis_Homo sapiens_hsa051310.69889623
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69218591
84Apoptosis_Homo sapiens_hsa042100.69086474
85African trypanosomiasis_Homo sapiens_hsa051430.68495244
86Notch signaling pathway_Homo sapiens_hsa043300.66567697
87Propanoate metabolism_Homo sapiens_hsa006400.66453237
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65924992
89Hepatitis C_Homo sapiens_hsa051600.65762604
90FoxO signaling pathway_Homo sapiens_hsa040680.65662821
91HIF-1 signaling pathway_Homo sapiens_hsa040660.65363184
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65212545
93Fatty acid elongation_Homo sapiens_hsa000620.64254288
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63661996
95Tyrosine metabolism_Homo sapiens_hsa003500.63640835
96Focal adhesion_Homo sapiens_hsa045100.63199922
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.62916398
98Choline metabolism in cancer_Homo sapiens_hsa052310.62787067
99Butanoate metabolism_Homo sapiens_hsa006500.62697816
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60898244
101Chronic myeloid leukemia_Homo sapiens_hsa052200.60523134
102Platelet activation_Homo sapiens_hsa046110.60521717
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.60513579
104Proteoglycans in cancer_Homo sapiens_hsa052050.60444350
105Thyroid cancer_Homo sapiens_hsa052160.60035319
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59554449
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58935485
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.58455589
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57588847
110Chemokine signaling pathway_Homo sapiens_hsa040620.57034932
111GnRH signaling pathway_Homo sapiens_hsa049120.56489485
112Endocytosis_Homo sapiens_hsa041440.56283352
113Antigen processing and presentation_Homo sapiens_hsa046120.56268033
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55528507
115Type I diabetes mellitus_Homo sapiens_hsa049400.52814742
116Prion diseases_Homo sapiens_hsa050200.51854425
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51607706
118Prostate cancer_Homo sapiens_hsa052150.50961414
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.49981696
120Fructose and mannose metabolism_Homo sapiens_hsa000510.49507183
121Lysosome_Homo sapiens_hsa041420.49299834
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49127641
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.48442351
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47799039
125Inositol phosphate metabolism_Homo sapiens_hsa005620.47794261
126Sulfur relay system_Homo sapiens_hsa041220.47554436
127Asthma_Homo sapiens_hsa053100.47225933
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46611776
129Glycerolipid metabolism_Homo sapiens_hsa005610.46603852
130Folate biosynthesis_Homo sapiens_hsa007900.46172731
131AMPK signaling pathway_Homo sapiens_hsa041520.46059711
132T cell receptor signaling pathway_Homo sapiens_hsa046600.44609467
1332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43397788
134Prolactin signaling pathway_Homo sapiens_hsa049170.43152373
135Dilated cardiomyopathy_Homo sapiens_hsa054140.41260345
136Salmonella infection_Homo sapiens_hsa051320.41091702
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40545476
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40198625
139Viral myocarditis_Homo sapiens_hsa054160.39095272
140Vitamin digestion and absorption_Homo sapiens_hsa049770.37365711

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »