ST3GAL1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oligosaccharide biosynthetic process (GO:0009312)7.99680162
2male sex determination (GO:0030238)5.66182323
3T cell migration (GO:0072678)5.25843634
4negative thymic T cell selection (GO:0045060)5.16159151
5negative regulation of stress fiber assembly (GO:0051497)5.11334235
6negative T cell selection (GO:0043383)5.04874567
7mast cell activation involved in immune response (GO:0002279)5.03239147
8mast cell degranulation (GO:0043303)5.03239147
9energy homeostasis (GO:0097009)4.29963721
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.18862966
11negative regulation of cell killing (GO:0031342)4.18862966
12positive thymic T cell selection (GO:0045059)4.18578351
13thymic T cell selection (GO:0045061)4.14539672
14mast cell activation (GO:0045576)3.97938956
15positive regulation of gamma-delta T cell activation (GO:0046645)3.90487308
16regulation of gamma-delta T cell differentiation (GO:0045586)3.89873561
17cellular response to interleukin-15 (GO:0071350)3.82064610
18regulation of B cell receptor signaling pathway (GO:0050855)3.81084514
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.75308402
20regulation of histone H3-K27 methylation (GO:0061085)3.72549574
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67681678
22negative regulation of actin filament bundle assembly (GO:0032232)3.63926838
23autophagic vacuole fusion (GO:0000046)3.63734782
24regulation of gamma-delta T cell activation (GO:0046643)3.61966134
25organelle membrane fusion (GO:0090174)3.58378696
26positive regulation of fatty acid beta-oxidation (GO:0032000)3.52497948
27positive regulation of triglyceride lipase activity (GO:0061365)3.49314507
28positive regulation of lipoprotein lipase activity (GO:0051006)3.49314507
29interferon-gamma secretion (GO:0072643)3.41085689
30barbed-end actin filament capping (GO:0051016)3.39965120
31leukocyte degranulation (GO:0043299)3.35321045
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.33843691
33positive regulation of granulocyte differentiation (GO:0030854)3.30494364
34T cell selection (GO:0045058)3.30086563
35positive T cell selection (GO:0043368)3.29019177
36positive regulation of macrophage differentiation (GO:0045651)3.25708359
37lymphocyte migration (GO:0072676)3.24875130
38antigen processing and presentation of endogenous antigen (GO:0019883)3.22994464
39lymph node development (GO:0048535)3.21643544
40negative regulation of toll-like receptor signaling pathway (GO:0034122)3.13801818
41regulation of T cell mediated cytotoxicity (GO:0001914)3.10254505
42regulation of glycogen (starch) synthase activity (GO:2000465)3.08552523
43hyaluronan catabolic process (GO:0030214)3.05541993
44response to interleukin-15 (GO:0070672)3.04654077
45negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.01488188
46negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.01377984
47positive regulation of T cell mediated cytotoxicity (GO:0001916)2.98330491
48negative regulation of glycogen metabolic process (GO:0070874)2.98124089
49leukocyte aggregation (GO:0070486)2.97896135
50positive regulation of fatty acid oxidation (GO:0046321)2.96420750
51N-acetylneuraminate metabolic process (GO:0006054)2.95633511
52rRNA methylation (GO:0031167)2.94727684
53regulation of autophagic vacuole assembly (GO:2000785)2.93773883
54negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.92553841
55negative regulation of smooth muscle cell differentiation (GO:0051151)2.91991356
56carnitine shuttle (GO:0006853)2.88959136
57histone H3-K36 demethylation (GO:0070544)2.88353983
58myeloid cell activation involved in immune response (GO:0002275)2.86406613
59sex determination (GO:0007530)2.84701701
60negative regulation of macroautophagy (GO:0016242)2.82444196
61oligosaccharide metabolic process (GO:0009311)2.80565410
62leukocyte tethering or rolling (GO:0050901)2.78033833
63response to muramyl dipeptide (GO:0032495)2.77985824
64negative regulation of T cell mediated immunity (GO:0002710)2.76761118
65tolerance induction (GO:0002507)2.75099672
66macroautophagy (GO:0016236)2.74032549
67maintenance of protein location in nucleus (GO:0051457)2.73726864
68negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.73169765
69negative regulation of innate immune response (GO:0045824)2.67039972
70negative regulation of lipid storage (GO:0010888)2.63639122
71natural killer cell differentiation (GO:0001779)2.62549182
72nucleotide transmembrane transport (GO:1901679)2.61975605
73positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.61358166
74zinc ion homeostasis (GO:0055069)2.60140239
75negative regulation of histone methylation (GO:0031061)2.59288286
76negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.58422697
77interferon-gamma production (GO:0032609)2.57521664
78interleukin-1-mediated signaling pathway (GO:0070498)2.55325741
79positive regulation of T cell mediated immunity (GO:0002711)2.50999523
80regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49998726
81positive regulation of cholesterol efflux (GO:0010875)2.49797425
82hepatocyte apoptotic process (GO:0097284)2.48734514
83positive regulation of glycogen metabolic process (GO:0070875)2.48561189
84positive regulation of alpha-beta T cell proliferation (GO:0046641)2.47922563
85diacylglycerol metabolic process (GO:0046339)2.47644559
86cellular zinc ion homeostasis (GO:0006882)2.45990264
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.45573855
88negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.42685619
89sleep (GO:0030431)2.42151074
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.42042998
91negative regulation of glycogen biosynthetic process (GO:0045719)2.40327953
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.37880564
93regulation of interferon-beta biosynthetic process (GO:0045357)2.37331974
94neutrophil activation involved in immune response (GO:0002283)2.36400762
95regulation of cholesterol homeostasis (GO:2000188)2.34195823
96regulation of T cell mediated immunity (GO:0002709)2.33957734
97biotin metabolic process (GO:0006768)2.33915435
98protein K11-linked deubiquitination (GO:0035871)2.30717969
99positive regulation of alpha-beta T cell differentiation (GO:0046638)2.30093094
100regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.30077440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.37166071
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.06292401
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.19740509
4AR_21572438_ChIP-Seq_LNCaP_Human3.02415444
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.82963050
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.80243681
7RUNX_20019798_ChIP-Seq_JUKART_Human2.67204216
8MYB_26560356_Chip-Seq_TH2_Human2.62341457
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.61628281
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58286624
11MAF_26560356_Chip-Seq_TH1_Human2.54096472
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51607991
13MYC_22102868_ChIP-Seq_BL_Human2.47845738
14SCL_19346495_ChIP-Seq_HPC-7_Human2.45276792
15VDR_21846776_ChIP-Seq_THP-1_Human2.36545269
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.30594869
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26659586
18MYB_26560356_Chip-Seq_TH1_Human2.21208343
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.20993251
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.18445221
21MAF_26560356_Chip-Seq_TH2_Human2.15615581
22UTX_26944678_Chip-Seq_JUKART_Human2.13633158
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09785167
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.06229926
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03629683
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98499471
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97726404
28VDR_24763502_ChIP-Seq_THP-1_Human1.95311615
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94962802
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89593256
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86178852
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83615116
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.81201770
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.72426443
35SPI1_23547873_ChIP-Seq_NB4_Human1.72072323
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.68731380
37NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66883979
38SPI1_23127762_ChIP-Seq_K562_Human1.65960195
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.63740508
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63260976
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62950532
42HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.62585352
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.59063360
44GATA3_27048872_Chip-Seq_THYMUS_Human1.57134871
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.56152763
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55574778
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.51397923
48GATA3_26560356_Chip-Seq_TH2_Human1.49997951
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48204624
50VDR_24787735_ChIP-Seq_THP-1_Human1.47252031
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47110094
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43326575
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41983371
54ZNF263_19887448_ChIP-Seq_K562_Human1.40406350
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39056898
56KDM2B_26808549_Chip-Seq_DND41_Human1.37809502
57SPI1_20517297_ChIP-Seq_HL60_Human1.35662545
58TFEB_21752829_ChIP-Seq_HELA_Human1.35485973
59CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34456913
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33333910
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32679772
62LXR_22292898_ChIP-Seq_THP-1_Human1.31208885
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29877057
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28155135
65KDM5A_27292631_Chip-Seq_BREAST_Human1.26791590
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24702455
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.23895570
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23790275
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23484578
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22041138
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.18463080
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18022714
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16096208
74TCF7_22412390_ChIP-Seq_EML_Mouse1.15382571
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15358471
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13708716
77TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13163475
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12348886
79BCOR_27268052_Chip-Seq_Bcells_Human1.12001796
80GATA1_22025678_ChIP-Seq_K562_Human1.11457430
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11270935
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10435966
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10435966
84NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10115736
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09847173
86RACK7_27058665_Chip-Seq_MCF-7_Human1.09083076
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07548019
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05863020
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04476091
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.03256007
91ELF5_23300383_ChIP-Seq_T47D_Human1.01207412
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98825012
93BCL6_27268052_Chip-Seq_Bcells_Human0.98530548
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.98372263
95CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97358210
96SA1_27219007_Chip-Seq_ERYTHROID_Human0.96620580
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96440793
98PHF8_20622854_ChIP-Seq_HELA_Human0.96341935
99PU_27001747_Chip-Seq_BMDM_Mouse0.95834054
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94194798

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.24401480
2MP0005671_abnormal_response_to3.76490611
3MP0003763_abnormal_thymus_physiology3.70753464
4MP0009840_abnormal_foam_cell3.60140825
5MP0003191_abnormal_cellular_cholesterol3.22527900
6MP0003724_increased_susceptibility_to3.12092243
7MP0000685_abnormal_immune_system2.53956926
8MP0002877_abnormal_melanocyte_morpholog2.38469004
9MP0005000_abnormal_immune_tolerance2.31649295
10MP0003195_calcinosis2.27771643
11MP0001800_abnormal_humoral_immune2.24530179
12MP0003436_decreased_susceptibility_to2.15362595
13MP0005464_abnormal_platelet_physiology2.11900746
14MP0004381_abnormal_hair_follicle2.08126714
15MP0002723_abnormal_immune_serum2.04614603
16MP0002452_abnormal_antigen_presenting1.99920718
17MP0001819_abnormal_immune_cell1.99778417
18MP0002420_abnormal_adaptive_immunity1.98184403
19MP0002405_respiratory_system_inflammati1.93031694
20MP0000465_gastrointestinal_hemorrhage1.89763876
21MP0005025_abnormal_response_to1.86030658
22MP0010386_abnormal_urinary_bladder1.85255396
23MP0002419_abnormal_innate_immunity1.75480314
24MP0010368_abnormal_lymphatic_system1.75157443
25MP0009785_altered_susceptibility_to1.73458328
26MP0005058_abnormal_lysosome_morphology1.73196718
27MP0005387_immune_system_phenotype1.70385821
28MP0001790_abnormal_immune_system1.70385821
29MP0003828_pulmonary_edema1.63529673
30MP0005310_abnormal_salivary_gland1.62110408
31MP0003300_gastrointestinal_ulcer1.62069849
32MP0002148_abnormal_hypersensitivity_rea1.56231708
33MP0001533_abnormal_skeleton_physiology1.54310291
34MP0001835_abnormal_antigen_presentation1.54139097
35MP0002398_abnormal_bone_marrow1.52644798
36MP0002166_altered_tumor_susceptibility1.51192154
37MP0000716_abnormal_immune_system1.50596994
38MP0004947_skin_inflammation1.49778527
39MP0001845_abnormal_inflammatory_respons1.44385324
40MP0004272_abnormal_basement_membrane1.44305241
41MP0000703_abnormal_thymus_morphology1.43595427
42MP0002998_abnormal_bone_remodeling1.41930283
43MP0002722_abnormal_immune_system1.41426904
44MP0006072_abnormal_retinal_apoptosis1.38212750
45MP0005647_abnormal_sex_gland1.32948095
46MP0000689_abnormal_spleen_morphology1.25369952
47MP0008961_abnormal_basal_metabolism1.25319129
48MP0005076_abnormal_cell_differentiation1.25177225
49MP0002933_joint_inflammation1.24080469
50MP0002429_abnormal_blood_cell1.20861146
51MP0003091_abnormal_cell_migration1.19797191
52MP0006082_CNS_inflammation1.18638899
53MP0001873_stomach_inflammation1.15698296
54MP0000858_altered_metastatic_potential1.15200655
55MP0010155_abnormal_intestine_physiology1.12208253
56MP0008004_abnormal_stomach_pH1.06292656
57MP0002006_tumorigenesis1.05631606
58MP0003315_abnormal_perineum_morphology1.03663354
59MP0003045_fibrosis1.03211980
60MP0005390_skeleton_phenotype1.02178121
61MP0002168_other_aberrant_phenotype1.01150190
62MP0009278_abnormal_bone_marrow1.00343713
63MP0005451_abnormal_body_composition1.00150394
64MP0003866_abnormal_defecation0.98700001
65MP0001849_ear_inflammation0.97205002
66MP0005166_decreased_susceptibility_to0.96377555
67MP0003136_yellow_coat_color0.92041141
68MP0003959_abnormal_lean_body0.91215249
69MP0010329_abnormal_lipoprotein_level0.90074049
70MP0003303_peritoneal_inflammation0.89907171
71MP0009333_abnormal_splenocyte_physiolog0.89263062
72MP0004233_abnormal_muscle_weight0.88938401
73MP0001661_extended_life_span0.88553153
74MP0009764_decreased_sensitivity_to0.87890359
75MP0004130_abnormal_muscle_cell0.87588296
76MP0003566_abnormal_cell_adhesion0.87161211
77MP0008469_abnormal_protein_level0.86597913
78MP0002139_abnormal_hepatobiliary_system0.86446066
79MP0001348_abnormal_lacrimal_gland0.85065757
80MP0000249_abnormal_blood_vessel0.84960201
81MP0003795_abnormal_bone_structure0.84847899
82MP0002090_abnormal_vision0.84601198
83MP0002132_abnormal_respiratory_system0.84508965
84MP0005365_abnormal_bile_salt0.83503430
85MP0003879_abnormal_hair_cell0.81474830
86MP0000747_muscle_weakness0.78260267
87MP0009643_abnormal_urine_homeostasis0.78247202
88MP0005448_abnormal_energy_balance0.77401565
89MP0001243_abnormal_dermal_layer0.76476952
90MP0000490_abnormal_crypts_of0.75040365
91MP0002136_abnormal_kidney_physiology0.73746385
92MP0003646_muscle_fatigue0.72461553
93MP0000343_altered_response_to0.71474650
94MP0005167_abnormal_blood-brain_barrier0.70213877
95MP0002163_abnormal_gland_morphology0.70097261
96MP0001502_abnormal_circadian_rhythm0.69953990
97MP0003075_altered_response_to0.69778279
98MP0003448_altered_tumor_morphology0.69743637
99MP0003638_abnormal_response/metabolism_0.68200439
100MP0008438_abnormal_cutaneous_collagen0.65551446

Predicted human phenotypes

RankGene SetZ-score
1Thoracic kyphosis (HP:0002942)5.41532761
2Abnormality of the thoracic spine (HP:0100711)4.09536879
3Severe combined immunodeficiency (HP:0004430)3.64185640
4Panhypogammaglobulinemia (HP:0003139)3.63843268
5T lymphocytopenia (HP:0005403)3.60070120
6Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)3.52003703
7Abnormality of the lumbar spine (HP:0100712)3.50765917
8Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.44651932
9Nonimmune hydrops fetalis (HP:0001790)3.35497484
10Global brain atrophy (HP:0002283)3.35218298
11Vacuolated lymphocytes (HP:0001922)3.30257353
12Abnormality of T cell number (HP:0011839)3.23212886
13Abnormality of glycolipid metabolism (HP:0010969)3.22551555
14Abnormality of liposaccharide metabolism (HP:0010968)3.22551555
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.22551555
16Eczematoid dermatitis (HP:0000976)3.13375171
17Combined immunodeficiency (HP:0005387)3.11753004
18Abnormal protein glycosylation (HP:0012346)2.95958226
19Abnormal glycosylation (HP:0012345)2.95958226
20Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.95958226
21Abnormal protein N-linked glycosylation (HP:0012347)2.95958226
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.88308434
23Vascular calcification (HP:0004934)2.82929929
24Mucopolysacchariduria (HP:0008155)2.70060970
25Urinary glycosaminoglycan excretion (HP:0003541)2.70060970
26Renal cortical cysts (HP:0000803)2.69721822
27J-shaped sella turcica (HP:0002680)2.67098459
28Dysostosis multiplex (HP:0000943)2.64427020
29Abnormality of the frontal sinuses (HP:0002687)2.64383911
30Abnormality of the columella (HP:0009929)2.61126714
31Cardiovascular calcification (HP:0011915)2.59608217
32Beaking of vertebral bodies (HP:0004568)2.58425725
33Recurrent fungal infections (HP:0002841)2.56262639
34Abnormality of T cells (HP:0002843)2.53560624
35Autoimmune thrombocytopenia (HP:0001973)2.52875833
36Retinal atrophy (HP:0001105)2.50866323
37Protruding tongue (HP:0010808)2.48816702
38Reduced antithrombin III activity (HP:0001976)2.45575882
39Self-mutilation (HP:0000742)2.44961524
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.44816407
41Hemorrhage of the eye (HP:0011885)2.43711585
42Thickened calvaria (HP:0002684)2.38134789
43Spondylolisthesis (HP:0003302)2.35114066
44Increased cerebral lipofuscin (HP:0011813)2.33907840
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33329527
46Abnormality of polysaccharide metabolism (HP:0011012)2.33329527
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33329527
48Persistence of primary teeth (HP:0006335)2.31635548
49Alopecia of scalp (HP:0002293)2.28118802
50Gastrointestinal infarctions (HP:0005244)2.27509758
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.25124581
52Granulocytopenia (HP:0001913)2.23838993
53Spontaneous hematomas (HP:0007420)2.21437556
54Gonadal dysgenesis (HP:0000133)2.20269843
55Abnormality of eosinophils (HP:0001879)2.20059686
56Anhidrosis (HP:0000970)2.19022122
57Abnormality of the pericardium (HP:0001697)2.18289219
58Poor head control (HP:0002421)2.16547980
59Recurrent viral infections (HP:0004429)2.15475549
60Abnormality of the prostate (HP:0008775)2.14058072
61Recurrent corneal erosions (HP:0000495)2.13978195
62Cheilitis (HP:0100825)2.11867234
63Delayed closure of the anterior fontanelle (HP:0001476)2.11740924
64Prolonged neonatal jaundice (HP:0006579)2.11141644
65Large for gestational age (HP:0001520)2.06902054
66Pustule (HP:0200039)2.05517254
67Eosinophilia (HP:0001880)2.04628983
68Capillary hemangiomas (HP:0005306)2.04231009
69Myositis (HP:0100614)2.02710334
70Polymicrogyria (HP:0002126)2.01818648
71Cortical dysplasia (HP:0002539)2.00710565
72Chronic mucocutaneous candidiasis (HP:0002728)1.99305275
73Recurrent cutaneous fungal infections (HP:0011370)1.99305275
74Thoracolumbar scoliosis (HP:0002944)1.97059555
75Brushfield spots (HP:0001088)1.93925801
76Follicular hyperkeratosis (HP:0007502)1.89444912
77Colitis (HP:0002583)1.88651195
78Autoimmune hemolytic anemia (HP:0001890)1.87674635
79Mitral stenosis (HP:0001718)1.87159425
80Inflammation of the large intestine (HP:0002037)1.86852715
81Abnormality of dental color (HP:0011073)1.86478961
82Ureteral duplication (HP:0000073)1.85853078
83Arterial thrombosis (HP:0004420)1.85847293
84Seborrheic dermatitis (HP:0001051)1.85162256
85Epistaxis (HP:0000421)1.84023871
86Retrobulbar optic neuritis (HP:0100654)1.83545024
87Optic neuritis (HP:0100653)1.83545024
88Deformed sella turcica (HP:0002681)1.83011708
89Intellectual disability, progressive (HP:0006887)1.82476213
90Protuberant abdomen (HP:0001538)1.80589396
91Conical tooth (HP:0000698)1.79830257
92Slow saccadic eye movements (HP:0000514)1.76993637
93Abnormal number of erythroid precursors (HP:0012131)1.76540918
94Pulmonary infiltrates (HP:0002113)1.74145085
95Craniofacial hyperostosis (HP:0004493)1.73843344
96Type I transferrin isoform profile (HP:0003642)1.71662578
97Abnormality of the sella turcica (HP:0002679)1.70399698
98Elevated erythrocyte sedimentation rate (HP:0003565)1.70100431
99Chronic diarrhea (HP:0002028)1.69636963
100Bulbar palsy (HP:0001283)1.68931143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.55907201
2INSRR4.30235500
3MUSK4.10615164
4MAP3K103.20661646
5ARAF3.20044837
6IRAK42.98688071
7MAP3K132.93585426
8ZAP702.66124217
9IRAK32.42807440
10BLK2.39717437
11GRK62.33090421
12TLK11.96471071
13TAOK31.82247020
14LATS11.80864713
15MAP4K11.73870404
16PIM21.67820712
17MAP3K141.64832738
18CDK121.61395153
19TXK1.54888578
20MAPKAPK31.49428758
21BMPR21.43415799
22MAP2K21.43200281
23TRIB31.35088856
24MAP3K91.25966519
25FES1.25434911
26EEF2K1.21532605
27CSF1R1.17633484
28EPHB11.13793340
29PRKCQ1.08367716
30NLK1.07735872
31PASK1.07334096
32MST41.07041735
33EPHA31.06264459
34PDGFRB1.05670195
35SYK1.04411286
36TBK11.02015502
37RAF10.99477085
38MATK0.97788782
39CSK0.97608107
40MELK0.95873348
41CAMKK20.93953685
42STK380.93844977
43MAP3K40.93842913
44BTK0.93232437
45PINK10.91769706
46IKBKB0.86088546
47KIT0.84612514
48LIMK10.82661448
49CAMK1D0.82514949
50JAK10.80282354
51CAMKK10.77785765
52ITK0.75721871
53CLK10.72105551
54MET0.71906001
55ICK0.70803372
56MAP3K10.70101900
57KSR20.70089357
58BMX0.69793792
59TAOK10.69363100
60CDK30.68161431
61JAK30.66408938
62BRAF0.66286077
63MST1R0.66007658
64PAK20.65345116
65STK38L0.65145067
66CDK40.63813618
67MARK30.63031886
68LCK0.62584141
69RIPK40.60959354
70PTK2B0.60942600
71SCYL20.58942094
72FGR0.58508455
73RPS6KA50.58497110
74MOS0.56913218
75NEK90.54467701
76RET0.53689538
77HCK0.53590090
78TAOK20.52036757
79LYN0.51938859
80MAP2K70.50220726
81RPS6KA40.50178380
82PBK0.48555249
83TESK10.44295578
84TRPM70.42705409
85RPS6KA60.42094647
86CDK60.40420808
87CHUK0.38519436
88PRPF4B0.37965121
89RPS6KA20.36960248
90FGFR40.36083350
91ADRBK10.35836627
92SIK10.34582212
93MAPK110.33883690
94VRK20.32652590
95EPHA20.31475956
96MAP3K80.29634721
97IGF1R0.29482754
98NEK20.29454928
99IKBKE0.29425783
100DAPK20.28625239

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.94536922
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.28269926
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.88769220
4Primary immunodeficiency_Homo sapiens_hsa053402.79781975
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.78952602
6B cell receptor signaling pathway_Homo sapiens_hsa046622.62631492
7Other glycan degradation_Homo sapiens_hsa005112.60046146
8T cell receptor signaling pathway_Homo sapiens_hsa046602.47237760
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.47152174
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.14863633
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74433209
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72947572
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72917732
14TNF signaling pathway_Homo sapiens_hsa046681.62654361
15Malaria_Homo sapiens_hsa051441.50064133
16Phototransduction_Homo sapiens_hsa047441.50062187
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48406274
18VEGF signaling pathway_Homo sapiens_hsa043701.47732096
19Apoptosis_Homo sapiens_hsa042101.43856870
20Leishmaniasis_Homo sapiens_hsa051401.41347904
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.36075867
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.32510010
23Non-small cell lung cancer_Homo sapiens_hsa052231.26004448
24Thyroid cancer_Homo sapiens_hsa052161.24021121
25Osteoclast differentiation_Homo sapiens_hsa043801.23635123
26Acute myeloid leukemia_Homo sapiens_hsa052211.23615212
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19676285
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.17534829
29Measles_Homo sapiens_hsa051621.16554821
30Bladder cancer_Homo sapiens_hsa052191.16386987
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16053050
32Pertussis_Homo sapiens_hsa051331.11147360
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10031436
34Hepatitis B_Homo sapiens_hsa051611.07586678
35Lysosome_Homo sapiens_hsa041421.06142293
36Small cell lung cancer_Homo sapiens_hsa052221.04784182
37Tuberculosis_Homo sapiens_hsa051521.04179863
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.99991694
39Influenza A_Homo sapiens_hsa051640.99824073
40Platelet activation_Homo sapiens_hsa046110.96415034
41Hematopoietic cell lineage_Homo sapiens_hsa046400.93402123
42Toxoplasmosis_Homo sapiens_hsa051450.93334513
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92104057
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.92028990
45Systemic lupus erythematosus_Homo sapiens_hsa053220.91757108
46Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90965052
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88658068
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88281545
49Prostate cancer_Homo sapiens_hsa052150.87500154
50Chemokine signaling pathway_Homo sapiens_hsa040620.85740392
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.84899627
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84395617
53Herpes simplex infection_Homo sapiens_hsa051680.78866345
54Starch and sucrose metabolism_Homo sapiens_hsa005000.76939632
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76919866
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.75335266
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74526426
58Chronic myeloid leukemia_Homo sapiens_hsa052200.73942428
59Antigen processing and presentation_Homo sapiens_hsa046120.73547699
60Olfactory transduction_Homo sapiens_hsa047400.72824037
61Arachidonic acid metabolism_Homo sapiens_hsa005900.71154813
62Peroxisome_Homo sapiens_hsa041460.70583844
63Graft-versus-host disease_Homo sapiens_hsa053320.69027286
64Ovarian steroidogenesis_Homo sapiens_hsa049130.68658624
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.68621842
66Endometrial cancer_Homo sapiens_hsa052130.67902653
67Staphylococcus aureus infection_Homo sapiens_hsa051500.67058251
68Shigellosis_Homo sapiens_hsa051310.65753461
69Legionellosis_Homo sapiens_hsa051340.64561838
70Viral carcinogenesis_Homo sapiens_hsa052030.64550863
71N-Glycan biosynthesis_Homo sapiens_hsa005100.64274805
72Insulin resistance_Homo sapiens_hsa049310.59358588
73Linoleic acid metabolism_Homo sapiens_hsa005910.59323562
74Allograft rejection_Homo sapiens_hsa053300.55065598
75MAPK signaling pathway_Homo sapiens_hsa040100.53570578
76Chemical carcinogenesis_Homo sapiens_hsa052040.51685459
77Pancreatic cancer_Homo sapiens_hsa052120.50655519
78Focal adhesion_Homo sapiens_hsa045100.50203999
79Hepatitis C_Homo sapiens_hsa051600.50140559
80Rheumatoid arthritis_Homo sapiens_hsa053230.49843385
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.49725498
82Autoimmune thyroid disease_Homo sapiens_hsa053200.49248663
83Insulin signaling pathway_Homo sapiens_hsa049100.48586467
84Choline metabolism in cancer_Homo sapiens_hsa052310.42820303
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42436181
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41840839
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39796817
88Type II diabetes mellitus_Homo sapiens_hsa049300.39705081
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39332245
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39165542
91Prolactin signaling pathway_Homo sapiens_hsa049170.39133527
92HTLV-I infection_Homo sapiens_hsa051660.38542971
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.38194093
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.37702613
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.37677893
96Vitamin digestion and absorption_Homo sapiens_hsa049770.37322248
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34948858
98ECM-receptor interaction_Homo sapiens_hsa045120.34832616
99GnRH signaling pathway_Homo sapiens_hsa049120.33753387
100Ras signaling pathway_Homo sapiens_hsa040140.31492890

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