ST3GAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)5.85131925
2locomotory exploration behavior (GO:0035641)5.03447184
3synaptic vesicle maturation (GO:0016188)4.86887624
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.61424059
5behavioral response to nicotine (GO:0035095)4.58043174
6purinergic nucleotide receptor signaling pathway (GO:0035590)4.31812222
7layer formation in cerebral cortex (GO:0021819)4.27144552
8positive regulation of gamma-delta T cell activation (GO:0046645)4.21706922
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.13697220
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.13037489
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.11118213
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.08804819
13vocalization behavior (GO:0071625)4.07437182
14sodium ion export (GO:0071436)3.94818807
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.92307228
16meiotic chromosome segregation (GO:0045132)3.89352535
17positive regulation of defense response to virus by host (GO:0002230)3.86014747
18cellular response to exogenous dsRNA (GO:0071360)3.83823437
19regulation of B cell receptor signaling pathway (GO:0050855)3.82712725
20negative regulation of cell killing (GO:0031342)3.82127496
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.82127496
22positive regulation by symbiont of host defense response (GO:0052509)3.81590631
23modulation by symbiont of host defense response (GO:0052031)3.81590631
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.81590631
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.81590631
26positive regulation by organism of defense response of other organism involved in symbiotic interact3.81590631
27modulation by symbiont of host immune response (GO:0052553)3.81590631
28regulation of synapse structural plasticity (GO:0051823)3.76149969
29DNA deamination (GO:0045006)3.74204231
30plasma membrane repair (GO:0001778)3.73561306
31regulation of interferon-beta biosynthetic process (GO:0045357)3.72127233
32exploration behavior (GO:0035640)3.72048275
33positive regulation of protein kinase C signaling (GO:0090037)3.69674993
34positive regulation of fibroblast migration (GO:0010763)3.68953087
35regulation of skeletal muscle contraction (GO:0014819)3.65878062
36cytoskeletal anchoring at plasma membrane (GO:0007016)3.64311373
37synaptic vesicle exocytosis (GO:0016079)3.63845369
38glutamate secretion (GO:0014047)3.55274253
39interferon-gamma production (GO:0032609)3.53652147
40regulation of glutamate receptor signaling pathway (GO:1900449)3.51968386
41dendritic spine morphogenesis (GO:0060997)3.48840851
42response to ATP (GO:0033198)3.47930702
43regulation of synaptic vesicle exocytosis (GO:2000300)3.45377281
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.40170448
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.38705362
46cellular potassium ion homeostasis (GO:0030007)3.38464142
47CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.35718803
48positive regulation of synapse maturation (GO:0090129)3.34293288
49neuromuscular process controlling balance (GO:0050885)3.33167000
50G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.32352521
51activation of protein kinase A activity (GO:0034199)3.30008884
52germinal center formation (GO:0002467)3.28733011
53B cell receptor signaling pathway (GO:0050853)3.27313928
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.26941124
55regulation of neuronal synaptic plasticity (GO:0048168)3.25459206
56adenosine receptor signaling pathway (GO:0001973)3.24662159
57purinergic receptor signaling pathway (GO:0035587)3.24508608
58neuronal action potential propagation (GO:0019227)3.24476567
59positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.24328592
60establishment of nucleus localization (GO:0040023)3.22800757
61positive regulation of CREB transcription factor activity (GO:0032793)3.21898246
62regulation of gamma-delta T cell activation (GO:0046643)3.20547058
63lens fiber cell differentiation (GO:0070306)3.19532546
64positive regulation of interferon-alpha production (GO:0032727)3.18472312
65macrophage activation involved in immune response (GO:0002281)3.15998259
66regulation of interferon-alpha production (GO:0032647)3.14766755
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13503062
68neurotransmitter secretion (GO:0007269)3.12065002
69peristalsis (GO:0030432)3.10259108
70cell communication by electrical coupling (GO:0010644)3.09830451
71protein localization to synapse (GO:0035418)3.09501414
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.09333764
73dendrite morphogenesis (GO:0048813)3.09137450
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.07319056
75proline transport (GO:0015824)3.07252857
76positive regulation of heat generation (GO:0031652)3.06938208
77DNA strand renaturation (GO:0000733)3.06043758
78negative regulation of interleukin-12 production (GO:0032695)3.02503465
79antigen processing and presentation of endogenous antigen (GO:0019883)3.00542911
80negative regulation of innate immune response (GO:0045824)2.99657678
81positive thymic T cell selection (GO:0045059)2.99571125
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.99403892
83negative regulation of cell aging (GO:0090344)2.98006066
84glutamate receptor signaling pathway (GO:0007215)2.97991857
85stress fiber assembly (GO:0043149)2.96850064
86regulation of synaptic vesicle transport (GO:1902803)2.95865382
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94618889
88regulation of dendritic spine morphogenesis (GO:0061001)2.94545883
89cellular response to interleukin-15 (GO:0071350)2.94238852
90response to interleukin-15 (GO:0070672)2.93940435
91tolerance induction (GO:0002507)2.93594748
92urinary tract smooth muscle contraction (GO:0014848)2.93275442
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92877120
94granulocyte differentiation (GO:0030851)2.91466555
95protein heterotrimerization (GO:0070208)2.91442590
96mannose metabolic process (GO:0006013)2.90518033
97response to peptidoglycan (GO:0032494)2.90200778
98negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.89860452
99regulation of T cell mediated cytotoxicity (GO:0001914)2.89565815
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88945304
101sphingosine metabolic process (GO:0006670)2.88641985
102regulation of ARF protein signal transduction (GO:0032012)2.88333830
103negative regulation of T cell mediated immunity (GO:0002710)2.87995595
104regulation of memory T cell differentiation (GO:0043380)2.87347559
105cerebellar Purkinje cell differentiation (GO:0021702)2.86958061
106synaptic transmission, glutamatergic (GO:0035249)2.85621801
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85108236
108gonadal mesoderm development (GO:0007506)2.84724414
109long-term memory (GO:0007616)2.83399575
110cerebellar Purkinje cell layer development (GO:0021680)2.81621673
111regulation of excitatory postsynaptic membrane potential (GO:0060079)2.79259341
112positive regulation of antigen processing and presentation (GO:0002579)2.79080469
113protein targeting to plasma membrane (GO:0072661)2.78893362
114negative regulation of telomere maintenance (GO:0032205)2.78458127
115positive regulation of T-helper 1 type immune response (GO:0002827)2.77937030
116regulation of interferon-beta production (GO:0032648)2.77270814
117cellular extravasation (GO:0045123)2.77112578
118negative regulation of Rho protein signal transduction (GO:0035024)2.76706500
119regulation of MHC class I biosynthetic process (GO:0045343)2.76113321
120regulation of mast cell activation (GO:0033003)2.75851417
121axonal fasciculation (GO:0007413)2.73129845
122regulation of interferon-gamma biosynthetic process (GO:0045072)2.72886937
123regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.71674301
124regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71427629
125regulation of gamma-delta T cell differentiation (GO:0045586)2.70991668
126snRNA transcription (GO:0009301)2.69566044
127G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.68797166
128cerebellar granule cell differentiation (GO:0021707)2.67546858
129neuron projection extension involved in neuron projection guidance (GO:1902284)2.66897686
130axon extension involved in axon guidance (GO:0048846)2.66897686
131regulation of defense response to virus by host (GO:0050691)2.66749192
132diol metabolic process (GO:0034311)2.66520771
133synaptic vesicle endocytosis (GO:0048488)2.66123537
134cell migration in hindbrain (GO:0021535)2.65607948
135neuron recognition (GO:0008038)2.63992859
136T-helper 1 type immune response (GO:0042088)2.63251677
137regulation of antigen processing and presentation (GO:0002577)2.62232617
138prepulse inhibition (GO:0060134)2.61882053
139regulation of postsynaptic membrane potential (GO:0060078)2.60519106
140negative regulation of tumor necrosis factor production (GO:0032720)2.60493419
141negative regulation of toll-like receptor signaling pathway (GO:0034122)2.60112187
142positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.59772704
143detection of molecule of bacterial origin (GO:0032490)2.59230451
144regulation of synaptic plasticity (GO:0048167)2.58603503
145negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57985636
146response to type I interferon (GO:0034340)2.57091579
147GDP-mannose metabolic process (GO:0019673)2.56778022
148axon extension (GO:0048675)2.56738352
149neuron-neuron synaptic transmission (GO:0007270)2.56520434
150dendritic spine organization (GO:0097061)2.56195673
151NAD biosynthetic process (GO:0009435)2.56189408
152mitotic cell cycle arrest (GO:0071850)2.56009683
153cytidine deamination (GO:0009972)2.55832349
154cytidine metabolic process (GO:0046087)2.55832349
155cytidine catabolic process (GO:0006216)2.55832349
156detection of light stimulus involved in visual perception (GO:0050908)2.55182244
157detection of light stimulus involved in sensory perception (GO:0050962)2.55182244
158positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.54777277
159regulation of clathrin-mediated endocytosis (GO:2000369)2.54363117
160positive regulation of axon extension (GO:0045773)2.54338147
161negative regulation of mast cell activation (GO:0033004)2.53723086
162response to muramyl dipeptide (GO:0032495)2.53625924
163negative regulation of lymphocyte mediated immunity (GO:0002707)2.53615261
164positive regulation of membrane potential (GO:0045838)2.53004551
165sulfation (GO:0051923)2.52825271
166regulation of interleukin-12 biosynthetic process (GO:0045075)2.52606606
167regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.51260087
168negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.51039192
169positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.50950166
170innervation (GO:0060384)2.50937217
171negative regulation of interleukin-1 production (GO:0032692)2.50085145
1723-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.49734103
173purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.49734103
174membrane depolarization during action potential (GO:0086010)2.48273245
175potassium ion import (GO:0010107)2.47187816
176gamma-aminobutyric acid transport (GO:0015812)2.47073582
177neuromuscular process (GO:0050905)2.46678975
178adherens junction assembly (GO:0034333)2.45749838
179neuron cell-cell adhesion (GO:0007158)2.44673229
180negative regulation of microtubule polymerization (GO:0031115)2.39104923
181regulation of dendritic spine development (GO:0060998)2.38968417
182vesicle transport along microtubule (GO:0047496)2.38544403
183neuromuscular process controlling posture (GO:0050884)2.36978827
184chondrocyte proliferation (GO:0035988)2.36294819
185regulation of ARF GTPase activity (GO:0032312)2.36291830
186glycine transport (GO:0015816)2.35663628
187negative regulation of catenin import into nucleus (GO:0035414)2.35621269
188membrane depolarization (GO:0051899)2.35526607
189cellular sodium ion homeostasis (GO:0006883)2.31537037
190positive regulation of dendritic spine morphogenesis (GO:0061003)2.31442701
191regulation of neurotransmitter secretion (GO:0046928)2.30474570
192neuron projection extension (GO:1990138)2.30387535
193auditory behavior (GO:0031223)2.30025434
194postsynaptic membrane organization (GO:0001941)2.29698740
195negative regulation of fatty acid transport (GO:2000192)2.29067238
196neurotransmitter transport (GO:0006836)2.28827628
197clathrin coat assembly (GO:0048268)2.28230665
198neurotransmitter-gated ion channel clustering (GO:0072578)2.26835589
199regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.26262452
200synapse organization (GO:0050808)2.25360947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.49230537
2VDR_21846776_ChIP-Seq_THP-1_Human4.08757948
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.99900978
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73287416
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73287416
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72022092
7MYC_22102868_ChIP-Seq_BL_Human2.67060737
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66925198
9GATA1_22025678_ChIP-Seq_K562_Human2.63521194
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61373026
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.60862106
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.60065043
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.57509372
14* VDR_24763502_ChIP-Seq_THP-1_Human2.54192730
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51439372
16* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.49560316
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.49139681
18MAF_26560356_Chip-Seq_TH2_Human2.45402279
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.45328464
20DROSHA_22980978_ChIP-Seq_HELA_Human2.43940284
21MAF_26560356_Chip-Seq_TH1_Human2.43757113
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41826537
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.38902619
24P68_20966046_ChIP-Seq_HELA_Human2.37061175
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33571127
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32162567
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32025309
28WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.29388423
29* BCL6_27268052_Chip-Seq_Bcells_Human2.24744688
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24230082
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.12623870
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12238088
33* BCOR_27268052_Chip-Seq_Bcells_Human2.12211440
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.11135907
35EZH2_27304074_Chip-Seq_ESCs_Mouse2.11056321
36TRIM28_21343339_ChIP-Seq_HEK293_Human2.10799715
37RNF2_27304074_Chip-Seq_ESCs_Mouse2.10327050
38* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09559462
39E2F1_20622854_ChIP-Seq_HELA_Human2.05791703
40KDM2B_26808549_Chip-Seq_K562_Human2.05632862
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04181311
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.02456710
43UTX_26944678_Chip-Seq_JUKART_Human2.00268417
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.97482956
45* SCL_19346495_ChIP-Seq_HPC-7_Human1.95502668
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95434146
47* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90539775
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90123435
49PHF8_20622854_ChIP-Seq_HELA_Human1.88530132
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86676478
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.84514090
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78257426
53* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.73788507
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.72798575
55* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.69412064
56KDM2B_26808549_Chip-Seq_DND41_Human1.69191494
57* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.67617537
58ELF1_20517297_ChIP-Seq_JURKAT_Human1.66274057
59* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.64914044
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.63287558
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62913362
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.62159625
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.61388895
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60973635
65* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60947513
66REST_21632747_ChIP-Seq_MESCs_Mouse1.57385918
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56791833
68* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.53828618
69* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.52604651
70* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51967295
71AR_21572438_ChIP-Seq_LNCaP_Human1.51025027
72CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50463395
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49795086
74* GATA1_19941827_ChIP-Seq_MEL_Mouse1.48692317
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.46890930
76GBX2_23144817_ChIP-Seq_PC3_Human1.45678083
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45459595
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.43402648
79* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43096677
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42922316
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42098779
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41833092
83P300_27268052_Chip-Seq_Bcells_Human1.41810617
84CTCF_21964334_ChIP-Seq_BJAB-B_Human1.41518724
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.40734146
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.40063370
87RARB_24833708_ChIP-Seq_LIVER_Mouse1.38471495
88* ERA_21632823_ChIP-Seq_H3396_Human1.38349657
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37244611
90ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36036855
91TP53_16413492_ChIP-PET_HCT116_Human1.35499874
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.34447041
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.33431163
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.32491402
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.32119128
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.31052244
97SMC4_20622854_ChIP-Seq_HELA_Human1.30714067
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.30589687
99LXR_22292898_ChIP-Seq_THP-1_Human1.30384362
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30050413
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30023310
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29660941
103CTCF_21964334_Chip-Seq_Bcells_Human1.29073903
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28233878
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.27352239
106RARA_24833708_ChIP-Seq_LIVER_Mouse1.26659830
107SPI1_23127762_ChIP-Seq_K562_Human1.25809770
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25532086
109SA1_27219007_Chip-Seq_Bcells_Human1.25363749
110SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25216792
111P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24996148
112* NCOR1_26117541_ChIP-Seq_K562_Human1.23691428
113* OCT4_19829295_ChIP-Seq_ESCs_Human1.22379586
114* RUNX_20019798_ChIP-Seq_JUKART_Human1.22255977
115CIITA_25753668_ChIP-Seq_RAJI_Human1.22224454
116MYB_26560356_Chip-Seq_TH1_Human1.21833866
117* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.21752803
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21671558
119PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21226431
120* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20992242
121NANOG_20526341_ChIP-Seq_ESCs_Human1.20128075
122OCT4_20526341_ChIP-Seq_ESCs_Human1.19843697
123* CTCF_20526341_ChIP-Seq_ESCs_Human1.19228569
124SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18821980
125RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17786604
126ZNF274_21170338_ChIP-Seq_K562_Hela1.17535767
127TET1_21451524_ChIP-Seq_MESCs_Mouse1.16721142
128* TAF2_19829295_ChIP-Seq_ESCs_Human1.16098580
129SPI1_23547873_ChIP-Seq_NB4_Human1.16081645
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15796646
131* EP300_21415370_ChIP-Seq_HL-1_Mouse1.15426541
132* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15382581
133AR_19668381_ChIP-Seq_PC3_Human1.15290302
134TP63_19390658_ChIP-ChIP_HaCaT_Human1.13980239
135BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.11381291
136BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10114340
137NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09956032
138TP53_22127205_ChIP-Seq_IMR90_Human1.09289281
139GATA3_27048872_Chip-Seq_THYMUS_Human1.08715125
140* RAC3_21632823_ChIP-Seq_H3396_Human1.08269231
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08201010
142* ELK3_25401928_ChIP-Seq_HUVEC_Human1.08004005
143* GATA2_19941826_ChIP-Seq_K562_Human1.07863971
144* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07233587
145CREB1_26743006_Chip-Seq_LNCaP_Human1.07120668
146* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05880135
147* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05707449
148ZNF263_19887448_ChIP-Seq_K562_Human1.05623398
149* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05103075
150MYB_26560356_Chip-Seq_TH2_Human1.04519969
151KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04205638
152ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04067184
153TET1_21490601_ChIP-Seq_MESCs_Mouse1.03440807
154CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02352713
155* FOXP1_21924763_ChIP-Seq_HESCs_Human1.02212407
156* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01771590
157CTCF_26484167_Chip-Seq_Bcells_Mouse1.01737623
158SPI1_20517297_ChIP-Seq_HL60_Human1.01437176
159* TP53_23651856_ChIP-Seq_MEFs_Mouse1.00300043
160SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99966562
161TCF7_22412390_ChIP-Seq_EML_Mouse0.99931735
162NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99347944
163VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97742532
164SOX2_21211035_ChIP-Seq_LN229_Gbm0.97396977
165ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97231134
166EGR1_19374776_ChIP-ChIP_THP-1_Human0.95429584
167ESR2_21235772_ChIP-Seq_MCF-7_Human0.95222899
168ISL1_27105846_Chip-Seq_CPCs_Mouse0.94336427
169RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91648141
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91064819
171CTCF_27219007_Chip-Seq_Bcells_Human0.90120282
172CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90032792
173RXR_22108803_ChIP-Seq_LS180_Human0.89215391
174RACK7_27058665_Chip-Seq_MCF-7_Human0.89051109
175OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88790780
176* GATA1_19941826_ChIP-Seq_K562_Human0.86933917
177SMAD4_21799915_ChIP-Seq_A2780_Human0.86135794
178SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85741194
179KLF4_19829295_ChIP-Seq_ESCs_Human0.85120578
180* SMAD3_21741376_ChIP-Seq_HESCs_Human0.84757598
181* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84090859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.66829675
2MP0005171_absent_coat_pigmentation4.66757872
3MP0001986_abnormal_taste_sensitivity4.48362577
4MP0003136_yellow_coat_color4.37071627
5MP0005174_abnormal_tail_pigmentation4.24241984
6MP0008438_abnormal_cutaneous_collagen3.19866506
7MP0003635_abnormal_synaptic_transmissio3.06535348
8MP0005623_abnormal_meninges_morphology2.94754257
9MP0000685_abnormal_immune_system2.90955845
10MP0003705_abnormal_hypodermis_morpholog2.49945372
11MP0005671_abnormal_response_to2.39728391
12MP0003436_decreased_susceptibility_to2.35928224
13MP0001790_abnormal_immune_system2.34986842
14MP0005387_immune_system_phenotype2.34986842
15MP0003646_muscle_fatigue2.31485915
16MP0000751_myopathy2.30560652
17MP0000015_abnormal_ear_pigmentation2.29641786
18MP0002063_abnormal_learning/memory/cond2.28685598
19MP0001800_abnormal_humoral_immune2.27576147
20MP0004270_analgesia2.26601248
21MP0004381_abnormal_hair_follicle2.20295814
22MP0003724_increased_susceptibility_to2.18674803
23MP0009046_muscle_twitch2.14696496
24MP0005503_abnormal_tendon_morphology2.13589748
25MP0004858_abnormal_nervous_system2.13369051
26MP0009745_abnormal_behavioral_response2.11349997
27MP0003880_abnormal_central_pattern2.09181061
28MP0004147_increased_porphyrin_level2.08836336
29MP0001835_abnormal_antigen_presentation2.07672257
30MP0002064_seizures1.99880513
31MP0004145_abnormal_muscle_electrophysio1.98815645
32MP0005083_abnormal_biliary_tract1.97734850
33MP0002723_abnormal_immune_serum1.93136461
34MP0005000_abnormal_immune_tolerance1.88742932
35MP0002452_abnormal_antigen_presenting1.86986427
36MP0002419_abnormal_innate_immunity1.84302142
37MP0008569_lethality_at_weaning1.84067098
38MP0009780_abnormal_chondrocyte_physiolo1.82319405
39MP0005275_abnormal_skin_tensile1.81398833
40MP0009278_abnormal_bone_marrow1.79236195
41MP0005025_abnormal_response_to1.77972329
42MP0003279_aneurysm1.76631183
43MP0004233_abnormal_muscle_weight1.75758097
44MP0002420_abnormal_adaptive_immunity1.75489460
45MP0001968_abnormal_touch/_nociception1.74396675
46MP0001819_abnormal_immune_cell1.74022645
47MP0001958_emphysema1.71038994
48MP0002148_abnormal_hypersensitivity_rea1.68807908
49MP0002572_abnormal_emotion/affect_behav1.67430215
50MP0002734_abnormal_mechanical_nocicepti1.55978990
51MP0005167_abnormal_blood-brain_barrier1.54110095
52MP0003283_abnormal_digestive_organ1.50872028
53MP0001299_abnormal_eye_distance/1.50344809
54MP0001440_abnormal_grooming_behavior1.48263251
55MP0009785_altered_susceptibility_to1.48001955
56MP0009764_decreased_sensitivity_to1.46673427
57MP0002653_abnormal_ependyma_morphology1.45619125
58MP0004811_abnormal_neuron_physiology1.44692510
59MP0002398_abnormal_bone_marrow1.43952752
60MP0002272_abnormal_nervous_system1.42758355
61MP0000716_abnormal_immune_system1.40748001
62MP0002138_abnormal_hepatobiliary_system1.40612112
63MP0002254_reproductive_system_inflammat1.40310419
64MP0003045_fibrosis1.39006990
65MP0003329_amyloid_beta_deposits1.38975274
66MP0002184_abnormal_innervation1.38837919
67MP0005423_abnormal_somatic_nervous1.37930760
68MP0003385_abnormal_body_wall1.37406493
69MP0000013_abnormal_adipose_tissue1.34841310
70MP0003763_abnormal_thymus_physiology1.33335306
71MP0002405_respiratory_system_inflammati1.32664751
72MP0003656_abnormal_erythrocyte_physiolo1.32168775
73MP0003091_abnormal_cell_migration1.32164056
74MP0002736_abnormal_nociception_after1.30491333
75MP0001501_abnormal_sleep_pattern1.29593831
76MP0005310_abnormal_salivary_gland1.27755290
77MP0000689_abnormal_spleen_morphology1.27125576
78MP0006082_CNS_inflammation1.26743164
79MP0003172_abnormal_lysosome_physiology1.25964484
80MP0001486_abnormal_startle_reflex1.25952921
81MP0004272_abnormal_basement_membrane1.20928526
82MP0002733_abnormal_thermal_nociception1.20038806
83MP0002429_abnormal_blood_cell1.20026579
84MP0008961_abnormal_basal_metabolism1.19425896
85MP0000733_abnormal_muscle_development1.19367864
86MP0002108_abnormal_muscle_morphology1.18299309
87MP0000759_abnormal_skeletal_muscle1.17545388
88MP0002877_abnormal_melanocyte_morpholog1.17514515
89MP0001970_abnormal_pain_threshold1.16152233
90MP0000747_muscle_weakness1.15820638
91MP0000955_abnormal_spinal_cord1.15608788
92MP0000778_abnormal_nervous_system1.15597534
93MP0002909_abnormal_adrenal_gland1.15491993
94MP0003122_maternal_imprinting1.15343797
95MP0004510_myositis1.14592781
96MP0002722_abnormal_immune_system1.14077839
97MP0000749_muscle_degeneration1.13847315
98MP0002067_abnormal_sensory_capabilities1.12775859
99MP0002638_abnormal_pupillary_reflex1.12341932
100MP0002735_abnormal_chemical_nociception1.11503452
101MP0004885_abnormal_endolymph1.11307023
102MP0000534_abnormal_ureter_morphology1.11262773
103MP0004087_abnormal_muscle_fiber1.11025016
104MP0000569_abnormal_digit_pigmentation1.08522241
105MP0001188_hyperpigmentation1.07442930
106MP0001873_stomach_inflammation1.07100175
107MP0003879_abnormal_hair_cell1.07011365
108MP0003195_calcinosis1.05989770
109MP0005409_darkened_coat_color1.05244023
110MP0002933_joint_inflammation1.05077772
111MP0001348_abnormal_lacrimal_gland1.03703996
112MP0005076_abnormal_cell_differentiation1.02936403
113MP0001845_abnormal_inflammatory_respons1.01876211
114MP0009333_abnormal_splenocyte_physiolog0.99087160
115MP0002557_abnormal_social/conspecific_i0.98232830
116MP0002066_abnormal_motor_capabilities/c0.96542930
117MP0000371_diluted_coat_color0.95806064
118MP0002882_abnormal_neuron_morphology0.95417478
119MP0002089_abnormal_postnatal_growth/wei0.94182082
120MP0002928_abnormal_bile_duct0.94124687
121MP0002152_abnormal_brain_morphology0.93072431
122MP0004043_abnormal_pH_regulation0.93039852
123MP0005369_muscle_phenotype0.91838426
124MP0000703_abnormal_thymus_morphology0.91422587
125MP0004084_abnormal_cardiac_muscle0.91193954
126MP0002822_catalepsy0.90666148
127MP0005508_abnormal_skeleton_morphology0.90582531
128MP0008469_abnormal_protein_level0.89768472
129MP0009250_abnormal_appendicular_skeleto0.89396583
130MP0004484_altered_response_of0.88874718
131MP0003566_abnormal_cell_adhesion0.88569910
132MP0001545_abnormal_hematopoietic_system0.88033830
133MP0005397_hematopoietic_system_phenotyp0.88033830
134MP0002106_abnormal_muscle_physiology0.87947125
135MP0009384_cardiac_valve_regurgitation0.87661700
136MP0003878_abnormal_ear_physiology0.87601213
137MP0005377_hearing/vestibular/ear_phenot0.87601213
138MP0002896_abnormal_bone_mineralization0.87443505
139MP0002234_abnormal_pharynx_morphology0.86519988
140MP0001533_abnormal_skeleton_physiology0.85558871
141MP0002095_abnormal_skin_pigmentation0.85235660
142MP0000428_abnormal_craniofacial_morphol0.85157864
143MP0003633_abnormal_nervous_system0.84682457
144MP0000003_abnormal_adipose_tissue0.83460911
145MP0005551_abnormal_eye_electrophysiolog0.83224516
146MP0001177_atelectasis0.82486991
147MP0002837_dystrophic_cardiac_calcinosis0.82318843
148MP0001663_abnormal_digestive_system0.80271311
149MP0005620_abnormal_muscle_contractility0.79747382
150MP0010155_abnormal_intestine_physiology0.79286057
151MP0003942_abnormal_urinary_system0.79091881
152MP0000750_abnormal_muscle_regeneration0.78542392
153MP0003115_abnormal_respiratory_system0.78505101
154MP0008770_decreased_survivor_rate0.77430052
155MP0003123_paternal_imprinting0.77403156
156MP0002075_abnormal_coat/hair_pigmentati0.77396999
157MP0002269_muscular_atrophy0.76890787
158MP0000538_abnormal_urinary_bladder0.76378878
159MP0008872_abnormal_physiological_respon0.75660574
160MP0004142_abnormal_muscle_tone0.75371641
161MP0001756_abnormal_urination0.75108993
162MP0008875_abnormal_xenobiotic_pharmacok0.74368432
163MP0003631_nervous_system_phenotype0.74065015
164MP0004215_abnormal_myocardial_fiber0.74054871
165MP0003300_gastrointestinal_ulcer0.73964898
166MP0004130_abnormal_muscle_cell0.73116077
167MP0005386_behavior/neurological_phenoty0.72868639
168MP0004924_abnormal_behavior0.72868639
169MP0004085_abnormal_heartbeat0.72824616
170MP0003303_peritoneal_inflammation0.72584270
171MP0001502_abnormal_circadian_rhythm0.71761506
172MP0000470_abnormal_stomach_morphology0.71745418
173MP0003634_abnormal_glial_cell0.69683790
174MP0010030_abnormal_orbit_morphology0.69187138
175MP0004947_skin_inflammation0.66900237
176MP0005451_abnormal_body_composition0.65400401
177MP0005084_abnormal_gallbladder_morpholo0.58934381
178MP0002998_abnormal_bone_remodeling0.56519593
179MP0002693_abnormal_pancreas_physiology0.54397957
180MP0002277_abnormal_respiratory_mucosa0.52526632
181MP0005584_abnormal_enzyme/coenzyme_acti0.52242366
182MP0002396_abnormal_hematopoietic_system0.50678294
183MP0002019_abnormal_tumor_incidence0.50234871
184MP0000230_abnormal_systemic_arterial0.49332255
185MP0003137_abnormal_impulse_conducting0.48958157
186MP0008874_decreased_physiological_sensi0.48647460

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.93965966
2Protrusio acetabuli (HP:0003179)4.48524873
3Rib fusion (HP:0000902)4.29418452
4Attenuation of retinal blood vessels (HP:0007843)4.18427444
5Premature rupture of membranes (HP:0001788)3.80747086
6Shallow orbits (HP:0000586)3.71813857
7Myokymia (HP:0002411)3.61304225
8Birth length less than 3rd percentile (HP:0003561)3.60239431
9Recurrent cutaneous fungal infections (HP:0011370)3.54920258
10Chronic mucocutaneous candidiasis (HP:0002728)3.54920258
11Patellar aplasia (HP:0006443)3.50838809
12Focal seizures (HP:0007359)3.41711390
13Intestinal fistula (HP:0100819)3.32420719
14Aplasia/Hypoplasia of the patella (HP:0006498)3.28959680
15Rectovaginal fistula (HP:0000143)3.26217182
16Rectal fistula (HP:0100590)3.26217182
17Gastrointestinal infarctions (HP:0005244)3.26145391
18Cerebral aneurysm (HP:0004944)3.25741436
19Recurrent fungal infections (HP:0002841)3.16808148
20Hypochromic anemia (HP:0001931)3.16082453
21Focal motor seizures (HP:0011153)3.14922207
22Visual hallucinations (HP:0002367)3.13107705
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.12127513
24Chorioretinal atrophy (HP:0000533)3.03704588
25Testicular atrophy (HP:0000029)3.02707059
26Facial diplegia (HP:0001349)2.97338961
27Pendular nystagmus (HP:0012043)2.92081699
28Ankle contracture (HP:0006466)2.87009726
29Action tremor (HP:0002345)2.84113944
30Retrobulbar optic neuritis (HP:0100654)2.83373289
31Optic neuritis (HP:0100653)2.83373289
32Bony spicule pigmentary retinopathy (HP:0007737)2.81275837
33Orchitis (HP:0100796)2.79300509
34Broad metatarsal (HP:0001783)2.79233804
35Myositis (HP:0100614)2.78433385
36Bladder diverticulum (HP:0000015)2.78094467
37Vaginal fistula (HP:0004320)2.75373391
38Poikiloderma (HP:0001029)2.75308650
39Increased variability in muscle fiber diameter (HP:0003557)2.72891943
40Pustule (HP:0200039)2.70141286
41Type 1 muscle fiber predominance (HP:0003803)2.69263634
42Genu recurvatum (HP:0002816)2.66458351
43Atonic seizures (HP:0010819)2.65791749
44Lower limb amyotrophy (HP:0007210)2.65676602
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.63255685
46Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.59427288
47Abnormal drinking behavior (HP:0030082)2.57086254
48Polydipsia (HP:0001959)2.57086254
49Thin bony cortex (HP:0002753)2.54380803
50Protruding tongue (HP:0010808)2.53311812
51Dilatation of the ascending aorta (HP:0005111)2.51738609
52Abnormal albumin level (HP:0012116)2.51508129
53Hypoalbuminemia (HP:0003073)2.51508129
54Insomnia (HP:0100785)2.51354817
55Squamous cell carcinoma (HP:0002860)2.48076928
56Achilles tendon contracture (HP:0001771)2.47982607
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.47790559
58Short chin (HP:0000331)2.46292508
59Panhypogammaglobulinemia (HP:0003139)2.45918063
60Progressive cerebellar ataxia (HP:0002073)2.44084394
61Bowel diverticulosis (HP:0005222)2.43305641
62Stomatitis (HP:0010280)2.42752392
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.42648986
64Mesangial abnormality (HP:0001966)2.42006804
65Hypoplasia of the pons (HP:0012110)2.41758504
66Abnormality of skeletal muscle fiber size (HP:0012084)2.41523335
67Absent thumb (HP:0009777)2.41496246
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.40787961
69Clumsiness (HP:0002312)2.40667165
70Annular pancreas (HP:0001734)2.36637573
71Pointed chin (HP:0000307)2.36269218
72Mitral valve prolapse (HP:0001634)2.35871290
73Elevated erythrocyte sedimentation rate (HP:0003565)2.32712176
74Ulnar bowing (HP:0003031)2.32512962
75Aortic dissection (HP:0002647)2.31954979
76Abnormality of the lower motor neuron (HP:0002366)2.31458118
77Upper limb amyotrophy (HP:0009129)2.30494491
78Distal upper limb amyotrophy (HP:0007149)2.30494491
79Fragile skin (HP:0001030)2.29252320
80Recurrent bacterial skin infections (HP:0005406)2.28671657
81Abnormality of the pons (HP:0007361)2.26473897
82Breast hypoplasia (HP:0003187)2.25994267
83Poikilocytosis (HP:0004447)2.24323052
84Increased connective tissue (HP:0009025)2.24068538
85Atrophic scars (HP:0001075)2.22806443
86Recurrent abscess formation (HP:0002722)2.21803883
87Depression (HP:0000716)2.21715419
88Encephalitis (HP:0002383)2.21205634
89Dysmetric saccades (HP:0000641)2.20964467
90Recurrent skin infections (HP:0001581)2.19505799
91Overgrowth (HP:0001548)2.19394123
92Slender build (HP:0001533)2.18867338
93Genetic anticipation (HP:0003743)2.18054020
94Facial hemangioma (HP:0000329)2.18020616
95Hyperacusis (HP:0010780)2.16859616
96Anorexia (HP:0002039)2.16780535
97Abnormality of homocysteine metabolism (HP:0010919)2.16384437
98Homocystinuria (HP:0002156)2.16384437
99Hemoptysis (HP:0002105)2.16108969
100Hypoventilation (HP:0002791)2.16037228
101Meningitis (HP:0001287)2.15439091
102Absence seizures (HP:0002121)2.14764496
103Hemiplegia (HP:0002301)2.13836114
104Aortic aneurysm (HP:0004942)2.12909899
105Eczematoid dermatitis (HP:0000976)2.12212321
106Obstructive sleep apnea (HP:0002870)2.11564220
107Abnormal number of erythroid precursors (HP:0012131)2.10519530
108Distal lower limb amyotrophy (HP:0008944)2.10287310
109Mediastinal lymphadenopathy (HP:0100721)2.10246338
110Vascular tortuosity (HP:0004948)2.09930004
111Flat occiput (HP:0005469)2.09911862
112Epileptic encephalopathy (HP:0200134)2.09908599
113Tubular atrophy (HP:0000092)2.09169356
114Hematochezia (HP:0002573)2.07988568
115Mildly elevated creatine phosphokinase (HP:0008180)2.07585527
116Febrile seizures (HP:0002373)2.07307991
117Generalized tonic-clonic seizures (HP:0002069)2.06426949
118Ankle clonus (HP:0011448)2.05888033
119Vasculitis (HP:0002633)2.05885064
120Increased cerebral lipofuscin (HP:0011813)2.05601446
121Keratoconjunctivitis (HP:0001096)2.05441251
122Abnormality of the Achilles tendon (HP:0005109)2.04858181
123Abnormality of macrophages (HP:0004311)2.03621517
124Hemorrhage of the eye (HP:0011885)2.03611344
125Poor eye contact (HP:0000817)2.03539798
126Wrist flexion contracture (HP:0001239)2.02872599
127Spinal rigidity (HP:0003306)2.02826385
128Supranuclear gaze palsy (HP:0000605)2.02345429
129Rectal prolapse (HP:0002035)2.02220043
130Arterial tortuosity (HP:0005116)2.01876208
131Papilledema (HP:0001085)1.98454563
132Increased number of teeth (HP:0011069)1.98252744
133Soft skin (HP:0000977)1.98227380
134Gastrointestinal stroma tumor (HP:0100723)1.97393152
135Enlarged penis (HP:0000040)1.97226066
136Mutism (HP:0002300)1.97105448
137Difficulty climbing stairs (HP:0003551)1.96847307
138Emphysema (HP:0002097)1.96426646
139Decreased circulating renin level (HP:0003351)1.96149615
140Colitis (HP:0002583)1.96046468
141Spontaneous hematomas (HP:0007420)1.94868451
142Hyperextensible skin (HP:0000974)1.94681433
143Buphthalmos (HP:0000557)1.93938861
144Abnormality of T cell physiology (HP:0011840)1.93214026
145Stomach cancer (HP:0012126)1.92988764
146Diplopia (HP:0000651)1.90506260
147Abnormality of binocular vision (HP:0011514)1.90506260
148Deviation of the hallux (HP:0010051)1.89838610
149Cheilitis (HP:0100825)1.89128805
150Tinnitus (HP:0000360)1.88759870
151Microcytic anemia (HP:0001935)1.88313028
152Bronchomalacia (HP:0002780)1.87984754
153Impaired social interactions (HP:0000735)1.87667747
154Abnormal social behavior (HP:0012433)1.87667747
155Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87031744
156Dysdiadochokinesis (HP:0002075)1.86540153
157Premature graying of hair (HP:0002216)1.86351367
158Difficulty running (HP:0009046)1.86034037
159Hypercortisolism (HP:0001578)1.84953033
160Small hand (HP:0200055)1.84669140
161Renal duplication (HP:0000075)1.84388970
162Striae distensae (HP:0001065)1.83480587
163Hallux valgus (HP:0001822)1.82047824
164Hypochromic microcytic anemia (HP:0004840)1.80429635
165IgG deficiency (HP:0004315)1.80278760
166Abnormality of midbrain morphology (HP:0002418)1.80052612
167Molar tooth sign on MRI (HP:0002419)1.80052612
168Ankyloglossia (HP:0010296)1.80002815
169Hand muscle atrophy (HP:0009130)1.79825085
170Dyschromatopsia (HP:0007641)1.79667217
171Megalencephaly (HP:0001355)1.79213244
172Abnormality of the hepatic vasculature (HP:0006707)1.78806914
173Polyuria (HP:0000103)1.78577626
174Narrow nasal bridge (HP:0000446)1.78484328
175Truncal ataxia (HP:0002078)1.77869721
176Abnormality of the fingertips (HP:0001211)1.77490327
177Dialeptic seizures (HP:0011146)1.77304899
178Global brain atrophy (HP:0002283)1.76823622
179Flat cornea (HP:0007720)1.76797372
180Myotonia (HP:0002486)1.76757492
181Peritonitis (HP:0002586)1.76448385
182Impaired smooth pursuit (HP:0007772)1.76425625
183Scapular winging (HP:0003691)1.75732669
184Basal cell carcinoma (HP:0002671)1.74476097
185Recurrent viral infections (HP:0004429)1.74462895
186Bundle branch block (HP:0011710)1.74196854
187Urinary bladder sphincter dysfunction (HP:0002839)1.72097401
188Wormian bones (HP:0002645)1.71451015
189Macroorchidism (HP:0000053)1.70836278
190Rapidly progressive (HP:0003678)1.70687379
191Aplasia involving bones of the extremities (HP:0009825)1.67725795
192Aplasia involving bones of the upper limbs (HP:0009823)1.67725795
193Aplasia of the phalanges of the hand (HP:0009802)1.67725795
194Hemiparesis (HP:0001269)1.67075438
195Insidious onset (HP:0003587)1.66525259
196Termporal pattern (HP:0011008)1.66525259
197Round ear (HP:0100830)1.66207510
198Impaired vibration sensation in the lower limbs (HP:0002166)1.65758413

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.49485261
2TRIB33.40452476
3NTRK33.16701913
4ACVR1B3.15162233
5BLK3.09515355
6MAP3K93.07626100
7FRK2.92373474
8WNK42.87341276
9MAP4K12.78585416
10EPHA42.55505453
11ZAK2.51411472
12ADRBK22.50659458
13PRKD32.49101692
14MAPK152.38841942
15PAK62.36567958
16CAMKK12.30646731
17MINK12.23069347
18LATS22.22415463
19RIPK12.17147364
20PKN22.13230617
21PDGFRA2.08766189
22KSR22.01915292
23DDR22.00505665
24BMPR1B1.93554786
25TTN1.93141132
26GRK61.91151055
27MAP3K41.89278915
28MAP2K31.88802352
29MARK11.87844516
30DAPK21.82135560
31IRAK41.78877801
32ERN11.77415435
33NTRK11.75977874
34TYRO31.56629913
35NTRK21.54829706
36TAOK11.52586804
37SYK1.51953191
38TAOK31.51217069
39DMPK1.49485546
40CSK1.47765077
41STK381.43900705
42ALK1.41850714
43BMX1.41511824
44SIK21.41421021
45EEF2K1.40382605
46PTK2B1.37805434
47CAMKK21.34077725
48IKBKE1.34055874
49MAP2K61.30715186
50IKBKB1.28369502
51KSR11.26710678
52ADRBK11.25403387
53PHKG11.23196767
54PHKG21.23196767
55MAP3K111.23072886
56ZAP701.20676901
57BTK1.19639837
58RET1.19551574
59PRKCH1.19244127
60CDK51.18199982
61TXK1.16770920
62MAP2K41.14517822
63MAP3K141.11479894
64PAK31.10942627
65PLK21.09095046
66TAOK21.08387784
67LYN1.05330282
68STK111.03927888
69RPS6KA61.01320222
70JAK31.01252312
71FER0.99892336
72CAMK1G0.98827583
73MAPK110.94508468
74CDK150.94489041
75WNK10.94261642
76TBK10.93886997
77CDK140.92751937
78PTK20.92667969
79KIT0.92620600
80TYK20.91916209
81ICK0.90399601
82OXSR10.89629436
83CDK180.89469700
84MELK0.89289311
85RIPK40.88619845
86CDC42BPA0.88424363
87PAK20.87882626
88TGFBR10.86328850
89HCK0.86002165
90MAP3K130.83396485
91PIM10.83286042
92CDK11A0.82292803
93SCYL20.80196675
94DAPK10.80148806
95GRK50.79560317
96MAP2K20.79497945
97MATK0.78960538
98PRKCQ0.78926679
99FES0.77909029
100GRK10.76929292
101PTK60.76861384
102PINK10.76322942
103PRPF4B0.76313525
104MARK20.76189328
105NEK20.75839340
106LMTK20.75778018
107CAMK10.74769847
108ITK0.74490833
109CDK40.74226310
110UHMK10.72836602
111CHUK0.72788583
112MAP2K10.72134477
113PRKCG0.71921153
114MAP2K70.70897350
115MAPK130.70291099
116DAPK30.69900062
117ROCK20.68809626
118MAP3K20.68535664
119MARK30.68512873
120EPHB20.67570666
121MOS0.67136093
122RPS6KC10.66000955
123RPS6KL10.66000955
124ROCK10.65900014
125RPS6KA50.65788283
126RPS6KA20.65681880
127HIPK20.64804667
128PRKD20.64398950
129PAK40.63464748
130LCK0.62791098
131NEK10.60573777
132MAP3K70.60547669
133JAK20.59699439
134PRKAA20.59231155
135ARAF0.58868876
136PDPK10.57640900
137CAMK40.57594781
138PDGFRB0.57509743
139SGK10.56362491
140CAMK1D0.55496939
141TRPM70.55495206
142SGK30.55489002
143FGFR10.55183269
144FGR0.51730588
145PDK10.50172714
146TEC0.49985059
147CAMK2A0.49676892
148RAF10.49522557
149CDK190.48977616
150IRAK30.48895261
151RPS6KA30.48245652
152ILK0.47969479
153IRAK20.46401516
154MTOR0.45356458
155TIE10.45039568
156TNK20.44761006
157PRKD10.44362009
158MAPK70.44310273
159IRAK10.43220219
160LIMK10.42212584
161PKN10.41843340
162NLK0.41840976
163FYN0.41735121
164MAPK100.40712912
165MAP3K10.39280930
166SRC0.39118705
167MAPK120.38037188
168CDK120.36811763
169CSF1R0.36691156
170GRK70.36117238
171PRKAA10.35739811
172PIK3CG0.34486863

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.82913240
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.75817811
3Primary immunodeficiency_Homo sapiens_hsa053402.69409075
4* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.42046206
5Nicotine addiction_Homo sapiens_hsa050332.19424821
6Long-term potentiation_Homo sapiens_hsa047202.16696985
7Graft-versus-host disease_Homo sapiens_hsa053322.13523171
8Allograft rejection_Homo sapiens_hsa053302.05486881
9Circadian entrainment_Homo sapiens_hsa047132.02886400
10Synaptic vesicle cycle_Homo sapiens_hsa047211.98671134
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96692594
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94078168
13Olfactory transduction_Homo sapiens_hsa047401.93976989
14B cell receptor signaling pathway_Homo sapiens_hsa046621.91019789
15Leishmaniasis_Homo sapiens_hsa051401.88614851
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85405870
17Osteoclast differentiation_Homo sapiens_hsa043801.85321216
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.84125149
19Glutamatergic synapse_Homo sapiens_hsa047241.81618696
20Autoimmune thyroid disease_Homo sapiens_hsa053201.80288369
21Amphetamine addiction_Homo sapiens_hsa050311.78489299
22Salivary secretion_Homo sapiens_hsa049701.75248640
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73023912
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72422619
25GABAergic synapse_Homo sapiens_hsa047271.70927474
26Gastric acid secretion_Homo sapiens_hsa049711.70448394
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68554820
28Glioma_Homo sapiens_hsa052141.65739829
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64796649
30Morphine addiction_Homo sapiens_hsa050321.63665879
31Oxytocin signaling pathway_Homo sapiens_hsa049211.63118726
32Dopaminergic synapse_Homo sapiens_hsa047281.62598813
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62264235
34Staphylococcus aureus infection_Homo sapiens_hsa051501.59617242
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56028312
36GnRH signaling pathway_Homo sapiens_hsa049121.53911626
37Cholinergic synapse_Homo sapiens_hsa047251.53820752
38Dilated cardiomyopathy_Homo sapiens_hsa054141.53105111
39Gap junction_Homo sapiens_hsa045401.52236979
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.51669435
41Long-term depression_Homo sapiens_hsa047301.49717472
42Hematopoietic cell lineage_Homo sapiens_hsa046401.49308449
43Tuberculosis_Homo sapiens_hsa051521.48503620
44Asthma_Homo sapiens_hsa053101.46235243
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42551234
46Renin secretion_Homo sapiens_hsa049241.41034395
47Estrogen signaling pathway_Homo sapiens_hsa049151.40283802
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38488791
49Insulin secretion_Homo sapiens_hsa049111.37026487
50TNF signaling pathway_Homo sapiens_hsa046681.32957603
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32389498
52Phototransduction_Homo sapiens_hsa047441.30910048
53Type I diabetes mellitus_Homo sapiens_hsa049401.28094292
54Cocaine addiction_Homo sapiens_hsa050301.27801169
55Malaria_Homo sapiens_hsa051441.25702493
56Calcium signaling pathway_Homo sapiens_hsa040201.24487783
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.23348994
58Focal adhesion_Homo sapiens_hsa045101.22687600
59Axon guidance_Homo sapiens_hsa043601.22377653
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.21516584
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.21516191
62Systemic lupus erythematosus_Homo sapiens_hsa053221.20863839
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19563387
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17959445
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17521519
66Melanogenesis_Homo sapiens_hsa049161.17438015
67cAMP signaling pathway_Homo sapiens_hsa040241.16940487
68cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15869305
69Neurotrophin signaling pathway_Homo sapiens_hsa047221.12177135
70ErbB signaling pathway_Homo sapiens_hsa040121.11149632
71Toxoplasmosis_Homo sapiens_hsa051451.10972604
72Influenza A_Homo sapiens_hsa051641.10156490
73Chemokine signaling pathway_Homo sapiens_hsa040621.08717574
74Phospholipase D signaling pathway_Homo sapiens_hsa040721.08323795
75ECM-receptor interaction_Homo sapiens_hsa045121.08108254
76Fanconi anemia pathway_Homo sapiens_hsa034601.07609811
77T cell receptor signaling pathway_Homo sapiens_hsa046601.07298180
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06411664
79Proteoglycans in cancer_Homo sapiens_hsa052051.05981244
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05748348
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05491851
82Taste transduction_Homo sapiens_hsa047421.04258903
83VEGF signaling pathway_Homo sapiens_hsa043701.04054132
84mTOR signaling pathway_Homo sapiens_hsa041501.02870687
85Measles_Homo sapiens_hsa051621.02591937
86Type II diabetes mellitus_Homo sapiens_hsa049301.02207221
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01174294
88Dorso-ventral axis formation_Homo sapiens_hsa043201.00837004
89Chronic myeloid leukemia_Homo sapiens_hsa052201.00077379
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99600736
91African trypanosomiasis_Homo sapiens_hsa051430.99560938
92Acute myeloid leukemia_Homo sapiens_hsa052210.97250963
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96241807
94Non-small cell lung cancer_Homo sapiens_hsa052230.95861685
95Serotonergic synapse_Homo sapiens_hsa047260.95659371
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94737869
97Homologous recombination_Homo sapiens_hsa034400.94307524
98Oocyte meiosis_Homo sapiens_hsa041140.94295913
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93362601
100Rap1 signaling pathway_Homo sapiens_hsa040150.92377234
101Endometrial cancer_Homo sapiens_hsa052130.92245783
102Selenocompound metabolism_Homo sapiens_hsa004500.91986150
103Renal cell carcinoma_Homo sapiens_hsa052110.91297219
104Sphingolipid metabolism_Homo sapiens_hsa006000.91012024
105MAPK signaling pathway_Homo sapiens_hsa040100.90984201
106Herpes simplex infection_Homo sapiens_hsa051680.90845468
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.89828190
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87638074
109Bladder cancer_Homo sapiens_hsa052190.85710643
110Amoebiasis_Homo sapiens_hsa051460.85264916
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84125156
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82096990
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81886990
114Choline metabolism in cancer_Homo sapiens_hsa052310.80397593
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.80209572
116* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79878729
117Platelet activation_Homo sapiens_hsa046110.79342111
118* Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78733346
119Endocytosis_Homo sapiens_hsa041440.78424100
120ABC transporters_Homo sapiens_hsa020100.78114980
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78085622
122Rheumatoid arthritis_Homo sapiens_hsa053230.78038041
123Fructose and mannose metabolism_Homo sapiens_hsa000510.77932334
124Hippo signaling pathway_Homo sapiens_hsa043900.77497806
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.75912865
126Thyroid hormone synthesis_Homo sapiens_hsa049180.74981816
127Wnt signaling pathway_Homo sapiens_hsa043100.74967976
128Colorectal cancer_Homo sapiens_hsa052100.74087579
129Lysosome_Homo sapiens_hsa041420.73977644
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73954929
131Cardiac muscle contraction_Homo sapiens_hsa042600.73577626
132Antigen processing and presentation_Homo sapiens_hsa046120.73069750
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72889139
134Melanoma_Homo sapiens_hsa052180.72819522
135Hepatitis B_Homo sapiens_hsa051610.72592913
136Insulin signaling pathway_Homo sapiens_hsa049100.71888927
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.71648566
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71495001
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69632962
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69444046
141Viral myocarditis_Homo sapiens_hsa054160.69405283
142Adherens junction_Homo sapiens_hsa045200.69306033
143Other glycan degradation_Homo sapiens_hsa005110.69063781
144Ovarian steroidogenesis_Homo sapiens_hsa049130.68261516
145Linoleic acid metabolism_Homo sapiens_hsa005910.67033005
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66751775
147Ras signaling pathway_Homo sapiens_hsa040140.66425855
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.65313542
149Apoptosis_Homo sapiens_hsa042100.65123991
150Glucagon signaling pathway_Homo sapiens_hsa049220.64413284
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63945570
152Tight junction_Homo sapiens_hsa045300.63776742
153Pancreatic cancer_Homo sapiens_hsa052120.63751672
154Hedgehog signaling pathway_Homo sapiens_hsa043400.63615881
155MicroRNAs in cancer_Homo sapiens_hsa052060.60868380
156Nitrogen metabolism_Homo sapiens_hsa009100.60262585
157Pancreatic secretion_Homo sapiens_hsa049720.59855887
158HIF-1 signaling pathway_Homo sapiens_hsa040660.59341040
159Ether lipid metabolism_Homo sapiens_hsa005650.58749090
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58575491
161Hepatitis C_Homo sapiens_hsa051600.58562865
162Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56615097
163Insulin resistance_Homo sapiens_hsa049310.56038497
164FoxO signaling pathway_Homo sapiens_hsa040680.54454210
165Glycerolipid metabolism_Homo sapiens_hsa005610.53497368
166Alcoholism_Homo sapiens_hsa050340.53200317
167Prolactin signaling pathway_Homo sapiens_hsa049170.52721773
168Viral carcinogenesis_Homo sapiens_hsa052030.51278619
169Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51230452
170Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48883070
171Glycerophospholipid metabolism_Homo sapiens_hsa005640.48822161
172Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47746309
173Vitamin digestion and absorption_Homo sapiens_hsa049770.42363875
174Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41294392
175Epstein-Barr virus infection_Homo sapiens_hsa051690.40243054

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