ST3GAL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal cholesterol absorption (GO:0030299)6.74488783
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.13510701
3intestinal absorption (GO:0050892)5.86387343
4melanin biosynthetic process (GO:0042438)5.42146856
5L-phenylalanine catabolic process (GO:0006559)5.03712451
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.03712451
7regulation of cholesterol esterification (GO:0010872)5.03044494
8high-density lipoprotein particle remodeling (GO:0034375)4.99286742
9phospholipid efflux (GO:0033700)4.93006010
10alpha-linolenic acid metabolic process (GO:0036109)4.92968619
11L-phenylalanine metabolic process (GO:0006558)4.89827995
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.89827995
13melanin metabolic process (GO:0006582)4.86049253
14plasma lipoprotein particle assembly (GO:0034377)4.83153192
15reverse cholesterol transport (GO:0043691)4.83152440
16regulation of triglyceride catabolic process (GO:0010896)4.81132004
17bile acid and bile salt transport (GO:0015721)4.69623440
18urea cycle (GO:0000050)4.63408650
19urea metabolic process (GO:0019627)4.63408650
20sulfur amino acid catabolic process (GO:0000098)4.60975495
21angiotensin maturation (GO:0002003)4.60457490
22negative regulation of cholesterol transport (GO:0032375)4.58176956
23negative regulation of sterol transport (GO:0032372)4.58176956
24COPI coating of Golgi vesicle (GO:0048205)4.53878287
25Golgi transport vesicle coating (GO:0048200)4.53878287
26protein-lipid complex remodeling (GO:0034368)4.52612243
27macromolecular complex remodeling (GO:0034367)4.52612243
28plasma lipoprotein particle remodeling (GO:0034369)4.52612243
29cholesterol efflux (GO:0033344)4.51151057
30protein-lipid complex assembly (GO:0065005)4.51026701
31very-low-density lipoprotein particle assembly (GO:0034379)4.48724472
32regulation of bile acid biosynthetic process (GO:0070857)4.47802065
33aromatic amino acid family catabolic process (GO:0009074)4.46921110
34cysteine metabolic process (GO:0006534)4.31799862
35flavonoid metabolic process (GO:0009812)4.31305268
36drug catabolic process (GO:0042737)4.29414215
37positive regulation of lipoprotein lipase activity (GO:0051006)4.24465260
38positive regulation of triglyceride lipase activity (GO:0061365)4.24465260
39amyloid precursor protein catabolic process (GO:0042987)4.24022705
40nitrogen cycle metabolic process (GO:0071941)4.20490064
41protein localization to endosome (GO:0036010)4.18572256
42lipoprotein metabolic process (GO:0042157)4.17211067
43regulation of cholesterol homeostasis (GO:2000188)4.16555015
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.13719289
45plasma lipoprotein particle clearance (GO:0034381)4.10011119
46cholesterol homeostasis (GO:0042632)4.08470063
47homocysteine metabolic process (GO:0050667)4.07730025
48barbed-end actin filament capping (GO:0051016)4.07567665
49bile acid metabolic process (GO:0008206)4.04870220
50complement activation, alternative pathway (GO:0006957)4.03862795
51indole-containing compound catabolic process (GO:0042436)4.03573896
52indolalkylamine catabolic process (GO:0046218)4.03573896
53tryptophan catabolic process (GO:0006569)4.03573896
54kynurenine metabolic process (GO:0070189)4.02651051
55bile acid biosynthetic process (GO:0006699)4.02495965
56sterol homeostasis (GO:0055092)4.01998220
57regulation of protein activation cascade (GO:2000257)3.96146685
58glyoxylate metabolic process (GO:0046487)3.92430902
59triglyceride homeostasis (GO:0070328)3.92277952
60acylglycerol homeostasis (GO:0055090)3.92277952
61plasma lipoprotein particle organization (GO:0071827)3.90549591
62secondary metabolite biosynthetic process (GO:0044550)3.89695508
63negative regulation of erythrocyte differentiation (GO:0045647)3.86812405
64peptidyl-glutamic acid carboxylation (GO:0017187)3.86315059
65protein carboxylation (GO:0018214)3.86315059
66negative regulation of fibrinolysis (GO:0051918)3.80905356
67protein-lipid complex subunit organization (GO:0071825)3.77869925
68tryptophan metabolic process (GO:0006568)3.77298494
69regulation of complement activation (GO:0030449)3.73612862
70pinocytosis (GO:0006907)3.72990402
71phospholipid homeostasis (GO:0055091)3.71200735
72low-density lipoprotein particle remodeling (GO:0034374)3.70591950
73basement membrane organization (GO:0071711)3.64545679
74amino-acid betaine metabolic process (GO:0006577)3.64418636
75cellular glucuronidation (GO:0052695)3.60738479
76cholesterol transport (GO:0030301)3.59324480
77sterol transport (GO:0015918)3.59324480
78positive regulation of triglyceride metabolic process (GO:0090208)3.56434166
79protein retention in ER lumen (GO:0006621)3.56132079
80regulation of fibrinolysis (GO:0051917)3.51899110
81ethanol oxidation (GO:0006069)3.50721324
82lysine catabolic process (GO:0006554)3.49217506
83lysine metabolic process (GO:0006553)3.49217506
84regulation of early endosome to late endosome transport (GO:2000641)3.48202533
85positive regulation of fatty acid biosynthetic process (GO:0045723)3.47681228
86maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.40285241
87regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.39505882
88positive regulation of lipid catabolic process (GO:0050996)3.39359340
89killing of cells of other organism (GO:0031640)3.33199998
90disruption of cells of other organism (GO:0044364)3.33199998
91positive regulation of Cdc42 GTPase activity (GO:0043089)3.33059508
92pentose-phosphate shunt (GO:0006098)3.29216441
93heme transport (GO:0015886)3.25982726
94drug metabolic process (GO:0017144)3.25854333
95negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.24566234
96retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.23783061
97hormone catabolic process (GO:0042447)3.22929430
98ethanol metabolic process (GO:0006067)3.17105491
99aromatic amino acid family metabolic process (GO:0009072)3.16583520
100regulation of cholesterol metabolic process (GO:0090181)3.13637288
101lipid homeostasis (GO:0055088)3.13317285
102glucuronate metabolic process (GO:0019585)3.12832941
103uronic acid metabolic process (GO:0006063)3.12832941
104negative regulation of cell size (GO:0045792)3.11147283
105negative regulation of lipase activity (GO:0060192)3.10983258
106arginine metabolic process (GO:0006525)3.10043444
107cellular modified amino acid catabolic process (GO:0042219)3.08672855
108drug transmembrane transport (GO:0006855)3.07571452
109regulation of cholesterol biosynthetic process (GO:0045540)3.07400139
110regulation of mammary gland epithelial cell proliferation (GO:0033599)3.06715038
111serine family amino acid catabolic process (GO:0009071)3.06108385
112response to nitrosative stress (GO:0051409)3.05838303
113protein maturation by protein folding (GO:0022417)3.05754870
114benzene-containing compound metabolic process (GO:0042537)3.04233762
115exogenous drug catabolic process (GO:0042738)3.04175312
116alpha-amino acid catabolic process (GO:1901606)3.02838314
117epoxygenase P450 pathway (GO:0019373)3.02564337
118glucocorticoid biosynthetic process (GO:0006704)3.01822346
119very long-chain fatty acid metabolic process (GO:0000038)3.01798975
120response to peptidoglycan (GO:0032494)3.00284688
121tyrosine metabolic process (GO:0006570)3.00244844
122adhesion of symbiont to host (GO:0044406)2.99901361
123epithelial cell-cell adhesion (GO:0090136)2.99543631
124glutamate metabolic process (GO:0006536)2.98521071
125amyloid precursor protein metabolic process (GO:0042982)2.98474343
126low-density lipoprotein particle clearance (GO:0034383)2.98302760
127negative regulation of homotypic cell-cell adhesion (GO:0034111)2.95101783
128glucose catabolic process (GO:0006007)2.92846265
129positive regulation of receptor recycling (GO:0001921)2.88866702
130detection of molecule of bacterial origin (GO:0032490)2.88455957
131desmosome organization (GO:0002934)2.82591451
132mannose metabolic process (GO:0006013)2.80723745
133stress fiber assembly (GO:0043149)2.80430966
134regulation of gonadotropin secretion (GO:0032276)2.79266022
135lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76125989
136positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.71323911
137NADPH regeneration (GO:0006740)2.71037305
138response to laminar fluid shear stress (GO:0034616)2.64443679
139activation of Rac GTPase activity (GO:0032863)2.64147002
140modulation by symbiont of host cellular process (GO:0044068)2.62453399
141endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.62046821
142semaphorin-plexin signaling pathway (GO:0071526)2.61691238
143regulation of cholesterol storage (GO:0010885)2.57937488
144hyaluronan catabolic process (GO:0030214)2.57672802
145C21-steroid hormone biosynthetic process (GO:0006700)2.56787633
146adherens junction assembly (GO:0034333)2.56224680
147positive regulation of blood vessel endothelial cell migration (GO:0043536)2.55638444
148negative regulation of focal adhesion assembly (GO:0051895)2.52914983
149negative regulation of cell junction assembly (GO:1901889)2.52914983
150negative regulation of adherens junction organization (GO:1903392)2.52914983
151focal adhesion assembly (GO:0048041)2.52907347
152cell-substrate adherens junction assembly (GO:0007045)2.52907347
153UV protection (GO:0009650)2.52828561
154hypotonic response (GO:0006971)2.52690785
155cell-substrate junction assembly (GO:0007044)2.52235057
156endothelial cell chemotaxis (GO:0035767)2.52076235
157skin morphogenesis (GO:0043589)2.48779101
158androgen biosynthetic process (GO:0006702)2.48540252
159embryonic process involved in female pregnancy (GO:0060136)2.48355021
160cytoskeletal anchoring at plasma membrane (GO:0007016)2.46648720
161membrane protein ectodomain proteolysis (GO:0006509)2.43853437
162negative regulation of fatty acid transport (GO:2000192)2.42130444
163positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.41486342
164peptidyl-proline hydroxylation (GO:0019511)2.41349003
165glucocorticoid metabolic process (GO:0008211)2.40708819
166vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.40688111
167positive regulation by symbiont of host defense response (GO:0052509)2.40283601
168modulation by symbiont of host defense response (GO:0052031)2.40283601
169modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.40283601
170modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.40283601
171positive regulation by organism of defense response of other organism involved in symbiotic interact2.40283601
172modulation by symbiont of host immune response (GO:0052553)2.40283601
173apoptotic process involved in morphogenesis (GO:0060561)2.39710722
174epithelial cell differentiation involved in prostate gland development (GO:0060742)2.39610474
175negative regulation of necroptotic process (GO:0060546)2.37770454
176glucose 6-phosphate metabolic process (GO:0051156)2.37629121
177regulation of leukocyte degranulation (GO:0043300)2.36604852
178cellular response to epinephrine stimulus (GO:0071872)2.36555837
179activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.36376171
180antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.31497646
181progesterone metabolic process (GO:0042448)2.30340130
182response to thyroid hormone (GO:0097066)2.29705989
183regulation of T-helper 2 cell differentiation (GO:0045628)2.28132959
184cortical actin cytoskeleton organization (GO:0030866)2.26123147
185regulation of necrotic cell death (GO:0010939)2.25896923
186regulation of membrane protein ectodomain proteolysis (GO:0051043)2.24644683
187cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.24519868
188positive regulation of nuclease activity (GO:0032075)2.24381044
189pigment cell differentiation (GO:0050931)2.24029304
190regulation of glucose import in response to insulin stimulus (GO:2001273)2.23107177
191maternal placenta development (GO:0001893)2.23058349
192protein hydroxylation (GO:0018126)2.22762249
193antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.22098220
194regulation of necroptotic process (GO:0060544)2.21058122
195negative regulation of viral release from host cell (GO:1902187)2.19756183
196hemidesmosome assembly (GO:0031581)2.18834605
197cellular response to thyroid hormone stimulus (GO:0097067)2.18545120
198membrane raft organization (GO:0031579)2.18473525
199germinal center formation (GO:0002467)2.17909445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.73579789
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.21661471
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.67586943
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.02993197
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.76335772
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.52660917
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.66526764
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.52214108
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.16717863
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.90494687
11VDR_21846776_ChIP-Seq_THP-1_Human2.72002807
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.58906880
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.34696979
14CDX2_20551321_ChIP-Seq_CACO-2_Human2.28799696
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.17394149
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17261494
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16914643
18GATA1_22025678_ChIP-Seq_K562_Human2.10228104
19CLOCK_20551151_ChIP-Seq_293T_Human2.08686592
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04916030
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96017300
22MYC_22102868_ChIP-Seq_BL_Human1.95570131
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88352618
24TCF7_22412390_ChIP-Seq_EML_Mouse1.84745297
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84694888
26GATA4_25053715_ChIP-Seq_YYC3_Human1.82694459
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.82011111
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.80336043
29* KDM2B_26808549_Chip-Seq_DND41_Human1.79399624
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76812015
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76066535
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75778414
33* VDR_24763502_ChIP-Seq_THP-1_Human1.71772229
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65478500
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65460235
36* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64856257
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58718376
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58084890
39* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57742278
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56887826
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.56151987
42* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54116466
43* KDM2B_26808549_Chip-Seq_K562_Human1.52304867
44* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50837798
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48907751
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48652800
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.47787040
48GATA6_25053715_ChIP-Seq_YYC3_Human1.44821766
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.44590807
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39009439
51* SOX2_20726797_ChIP-Seq_SW620_Human1.37207803
52TET1_21451524_ChIP-Seq_MESCs_Mouse1.32551540
53HNF4A_19822575_ChIP-Seq_HepG2_Human1.31522836
54P68_20966046_ChIP-Seq_HELA_Human1.31324339
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29052931
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.27039580
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26944945
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26267477
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25229980
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.24648365
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24291780
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24133956
63* NCOR1_26117541_ChIP-Seq_K562_Human1.24130222
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.22291358
65GATA1_19941826_ChIP-Seq_K562_Human1.22186150
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21961775
67* GATA2_19941826_ChIP-Seq_K562_Human1.21958125
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20794521
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.19062662
70NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18930957
71SMC4_20622854_ChIP-Seq_HELA_Human1.18421501
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17803505
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15810813
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15279015
75UTX_26944678_Chip-Seq_JUKART_Human1.13911521
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13790262
77LXR_22292898_ChIP-Seq_THP-1_Human1.13788086
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13701282
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.13691942
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13429180
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.13272460
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.12753822
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11390783
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11144477
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10672548
86SPI1_23127762_ChIP-Seq_K562_Human1.09760867
87* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09497960
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08638433
89* RACK7_27058665_Chip-Seq_MCF-7_Human1.08630524
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07204685
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06754260
92MAF_26560356_Chip-Seq_TH2_Human1.06589388
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06254265
94HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05833512
95ELF1_20517297_ChIP-Seq_JURKAT_Human1.05631839
96TP53_22127205_ChIP-Seq_IMR90_Human1.04794185
97* CREB1_26743006_Chip-Seq_LNCaP_Human1.04673407
98TBX20_22328084_ChIP-Seq_HEART_Mouse1.04282156
99TBX20_22080862_ChIP-Seq_HEART_Mouse1.04282156
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.02885512
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.02471211
102* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02233729
103SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01427220
104ZNF263_19887448_ChIP-Seq_K562_Human1.00824534
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00347224
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00337259
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00171924
108SCL_19346495_ChIP-Seq_HPC-7_Human0.99120475
109* GATA1_19941827_ChIP-Seq_MEL_Mouse0.98088063
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96943361
111IRF8_21731497_ChIP-ChIP_J774_Mouse0.96167712
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94185536
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.92838748
114EGR1_19032775_ChIP-ChIP_M12_Human0.90334955
115* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90028133
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89594248
117HTT_18923047_ChIP-ChIP_STHdh_Human0.88811511
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88648154
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86764483
120ESR1_20079471_ChIP-ChIP_T-47D_Human0.86494369
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85961396
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83868734
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83250751
124HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82732868
125ELK3_25401928_ChIP-Seq_HUVEC_Human0.81715496
126STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80602724
127GATA2_22383799_ChIP-Seq_G1ME_Mouse0.78323221
128P63_26484246_Chip-Seq_KERATINOCYTES_Human0.78165520
129* ATF3_27146783_Chip-Seq_COLON_Human0.77735207
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77549743
131BP1_19119308_ChIP-ChIP_Hs578T_Human0.77196465
132MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.75267704
133MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.74663844
134RXRA_24833708_ChIP-Seq_LIVER_Mouse0.73544056
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.73514391
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.73125793
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72945805
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72817502
139BCL6_27268052_Chip-Seq_Bcells_Human0.72163899
140* RUNX1_27514584_Chip-Seq_MCF-7_Human0.71915078
141E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.71903629
142FOXA1_25552417_ChIP-Seq_VCAP_Human0.71661051
143BCOR_27268052_Chip-Seq_Bcells_Human0.71627579
144* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71448281
145MAF_26560356_Chip-Seq_TH1_Human0.70263728
146SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67998031
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67029166
148RUNX1_22412390_ChIP-Seq_EML_Mouse0.64883664
149* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.64830704
150LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.64722814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.06218893
2MP0002139_abnormal_hepatobiliary_system6.35993803
3MP0005085_abnormal_gallbladder_physiolo5.02929317
4MP0005365_abnormal_bile_salt4.53677087
5MP0002877_abnormal_melanocyte_morpholog4.24814372
6MP0008875_abnormal_xenobiotic_pharmacok4.10695683
7MP0005171_absent_coat_pigmentation4.08427040
8MP0001666_abnormal_nutrient_absorption4.00932538
9MP0009840_abnormal_foam_cell3.81710438
10MP0003252_abnormal_bile_duct3.57802884
11MP0003806_abnormal_nucleotide_metabolis3.25821299
12MP0010329_abnormal_lipoprotein_level3.23688456
13MP0008438_abnormal_cutaneous_collagen2.85757557
14MP0005257_abnormal_intraocular_pressure2.57083099
15MP0008260_abnormal_autophagy2.53727726
16MP0005409_darkened_coat_color2.51531885
17MP0004381_abnormal_hair_follicle2.51013155
18MP0003191_abnormal_cellular_cholesterol2.47911326
19MP0000015_abnormal_ear_pigmentation2.29069639
20MP0003303_peritoneal_inflammation2.12892280
21MP0003566_abnormal_cell_adhesion2.12397568
22MP0002138_abnormal_hepatobiliary_system2.11362236
23MP0010234_abnormal_vibrissa_follicle2.03033151
24MP0005332_abnormal_amino_acid2.01421174
25MP0005083_abnormal_biliary_tract1.98758531
26MP0004858_abnormal_nervous_system1.94871711
27MP0000609_abnormal_liver_physiology1.90052097
28MP0004019_abnormal_vitamin_homeostasis1.87521719
29MP0003705_abnormal_hypodermis_morpholog1.87395393
30MP0000372_irregular_coat_pigmentation1.76853088
31MP0002118_abnormal_lipid_homeostasis1.75075264
32MP0004233_abnormal_muscle_weight1.72950289
33MP0003172_abnormal_lysosome_physiology1.72709455
34MP0001849_ear_inflammation1.72138760
35MP0005075_abnormal_melanosome_morpholog1.71040350
36MP0004264_abnormal_extraembryonic_tissu1.68243820
37MP0005076_abnormal_cell_differentiation1.65698524
38MP0008004_abnormal_stomach_pH1.61413719
39MP0004510_myositis1.58940392
40MP0004185_abnormal_adipocyte_glucose1.54754269
41MP0009278_abnormal_bone_marrow1.52297344
42MP0004147_increased_porphyrin_level1.52283580
43MP0000371_diluted_coat_color1.52050136
44MP0005319_abnormal_enzyme/_coenzyme1.50760880
45MP0003300_gastrointestinal_ulcer1.49951144
46MP0003656_abnormal_erythrocyte_physiolo1.45230918
47MP0003091_abnormal_cell_migration1.44046265
48MP0000858_altered_metastatic_potential1.43240772
49MP0003136_yellow_coat_color1.43082700
50MP0003868_abnormal_feces_composition1.39420862
51MP0003195_calcinosis1.37309975
52MP0002998_abnormal_bone_remodeling1.33408173
53MP0002075_abnormal_coat/hair_pigmentati1.32643166
54MP0005084_abnormal_gallbladder_morpholo1.32026350
55MP0005584_abnormal_enzyme/coenzyme_acti1.31921274
56MP0003183_abnormal_peptide_metabolism1.29905993
57MP0002254_reproductive_system_inflammat1.28219744
58MP0003828_pulmonary_edema1.27637377
59MP0009643_abnormal_urine_homeostasis1.26664746
60MP0004272_abnormal_basement_membrane1.24042545
61MP0002089_abnormal_postnatal_growth/wei1.18855516
62MP0003866_abnormal_defecation1.18074569
63MP0000604_amyloidosis1.18016032
64MP0003279_aneurysm1.14880909
65MP0009697_abnormal_copulation1.14668711
66MP0001764_abnormal_homeostasis1.14513426
67MP0001186_pigmentation_phenotype1.14403023
68MP0010155_abnormal_intestine_physiology1.13795158
69MP0005666_abnormal_adipose_tissue1.13516376
70MP0005167_abnormal_blood-brain_barrier1.12256204
71MP0000343_altered_response_to1.09810545
72MP0009764_decreased_sensitivity_to1.07287362
73MP0001873_stomach_inflammation1.06702927
74MP0003724_increased_susceptibility_to1.05029626
75MP0006054_spinal_hemorrhage1.04139355
76MP0004808_abnormal_hematopoietic_stem1.02738060
77MP0000598_abnormal_liver_morphology1.01293688
78MP0005501_abnormal_skin_physiology1.01027527
79MP0001851_eye_inflammation1.00217298
80MP0005375_adipose_tissue_phenotype0.99564911
81MP0008469_abnormal_protein_level0.99233512
82MP0001663_abnormal_digestive_system0.95454463
83MP0000750_abnormal_muscle_regeneration0.95097419
84MP0005165_increased_susceptibility_to0.94857547
85MP0004947_skin_inflammation0.94567890
86MP0003436_decreased_susceptibility_to0.93645941
87MP0000003_abnormal_adipose_tissue0.93574496
88* MP0005464_abnormal_platelet_physiology0.92016461
89MP0000462_abnormal_digestive_system0.91337979
90MP0009763_increased_sensitivity_to0.90033479
91MP0002896_abnormal_bone_mineralization0.89848961
92MP0001545_abnormal_hematopoietic_system0.88793662
93MP0005397_hematopoietic_system_phenotyp0.88793662
94MP0005330_cardiomyopathy0.87964362
95MP0001661_extended_life_span0.87677733
96MP0005451_abnormal_body_composition0.87530662
97MP0005621_abnormal_cell_physiology0.85115009
98MP0009384_cardiac_valve_regurgitation0.84920275
99MP0005636_abnormal_mineral_homeostasis0.84563400
100MP0001958_emphysema0.82568797
101MP0002095_abnormal_skin_pigmentation0.81689214
102MP0005381_digestive/alimentary_phenotyp0.80930496
103MP0005390_skeleton_phenotype0.80097280
104MP0009785_altered_susceptibility_to0.80040788
105MP0005166_decreased_susceptibility_to0.79100074
106MP0002148_abnormal_hypersensitivity_rea0.78630551
107MP0005448_abnormal_energy_balance0.77698136
108* MP0009642_abnormal_blood_homeostasis0.77483450
109MP0010368_abnormal_lymphatic_system0.76845077
110MP0003795_abnormal_bone_structure0.76741820
111MP0003634_abnormal_glial_cell0.76142733
112MP0010352_gastrointestinal_tract_polyps0.76073046
113MP0006138_congestive_heart_failure0.75348701
114MP0002332_abnormal_exercise_endurance0.75313021
115MP0000678_abnormal_parathyroid_gland0.74623415
116MP0003011_delayed_dark_adaptation0.73759930
117MP0001853_heart_inflammation0.73617368
118MP0003186_abnormal_redox_activity0.73037627
119MP0003329_amyloid_beta_deposits0.72812891
120MP0000477_abnormal_intestine_morphology0.72699539
121MP0005248_abnormal_Harderian_gland0.72167020
122MP0003690_abnormal_glial_cell0.71450374
123MP0001845_abnormal_inflammatory_respons0.71301780
124MP0009765_abnormal_xenobiotic_induced0.70825638
125MP0003075_altered_response_to0.70627462
126MP0001216_abnormal_epidermal_layer0.70396333
127MP0000751_myopathy0.70271660
128MP0005376_homeostasis/metabolism_phenot0.70220421
129MP0003448_altered_tumor_morphology0.68265657
130* MP0005025_abnormal_response_to0.68134812
131MP0002419_abnormal_innate_immunity0.68000518
132MP0003453_abnormal_keratinocyte_physiol0.66821376
133MP0006082_CNS_inflammation0.66657663
134MP0005174_abnormal_tail_pigmentation0.66650250
135MP0005197_abnormal_uvea_morphology0.65853073
136MP0002796_impaired_skin_barrier0.65821070
137MP0001915_intracranial_hemorrhage0.65579727
138MP0005023_abnormal_wound_healing0.65111692
139MP0000747_muscle_weakness0.64781766
140MP0005058_abnormal_lysosome_morphology0.64741822
141MP0010630_abnormal_cardiac_muscle0.64617631
142MP0005647_abnormal_sex_gland0.63887927
143MP0002876_abnormal_thyroid_physiology0.63541677
144MP0005000_abnormal_immune_tolerance0.62626079
145MP0002971_abnormal_brown_adipose0.62528942
146MP0005508_abnormal_skeleton_morphology0.62170419
147MP0002136_abnormal_kidney_physiology0.62095341
148MP0000733_abnormal_muscle_development0.61836215
149MP0000465_gastrointestinal_hemorrhage0.61410219
150MP0000249_abnormal_blood_vessel0.61147548
151MP0001533_abnormal_skeleton_physiology0.61107385
152MP0000627_abnormal_mammary_gland0.61041967
153MP0003638_abnormal_response/metabolism_0.57736836
154MP0000685_abnormal_immune_system0.57341781
155MP0008873_increased_physiological_sensi0.57166593
156MP0005334_abnormal_fat_pad0.56320101
157MP0005408_hypopigmentation0.55211130
158MP0009115_abnormal_fat_cell0.54232737
159MP0005266_abnormal_metabolism0.54104488
160MP0000490_abnormal_crypts_of0.53004918
161MP0000538_abnormal_urinary_bladder0.52221108
162MP0002060_abnormal_skin_morphology0.52078029
163MP0002132_abnormal_respiratory_system0.50369340
164MP0001881_abnormal_mammary_gland0.50111511
165MP0005164_abnormal_response_to0.48765600
166MP0001835_abnormal_antigen_presentation0.48598216
167MP0003878_abnormal_ear_physiology0.47754304
168MP0005377_hearing/vestibular/ear_phenot0.47754304
169MP0009379_abnormal_foot_pigmentation0.46609218

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.26462151
2Intrahepatic cholestasis (HP:0001406)5.76342653
3Xanthomatosis (HP:0000991)5.53725289
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.44860166
5Deep venous thrombosis (HP:0002625)5.39332716
6Abnormality of glutamine family amino acid metabolism (HP:0010902)5.30035710
7Abnormality of aromatic amino acid family metabolism (HP:0004338)5.02994279
8Hypolipoproteinemia (HP:0010981)4.53130381
9Prolonged partial thromboplastin time (HP:0003645)4.42915459
10Fat malabsorption (HP:0002630)4.30505489
11Acanthocytosis (HP:0001927)4.10011048
12Vertebral compression fractures (HP:0002953)4.04822116
13Complement deficiency (HP:0004431)4.04193247
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.02699608
15Hyperlipoproteinemia (HP:0010980)3.93758107
16Epidermoid cyst (HP:0200040)3.89463012
17Conjugated hyperbilirubinemia (HP:0002908)3.89133648
18Abnormality of sulfur amino acid metabolism (HP:0004339)3.81561367
19Ileus (HP:0002595)3.77580129
20Hyperammonemia (HP:0001987)3.74631939
21Protrusio acetabuli (HP:0003179)3.71187951
22Hypercholesterolemia (HP:0003124)3.65246230
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.62815271
24Abnormality of the common coagulation pathway (HP:0010990)3.55480121
25Malnutrition (HP:0004395)3.52823376
26Hypoalphalipoproteinemia (HP:0003233)3.48242361
27Abnormality of proline metabolism (HP:0010907)3.46986596
28Hydroxyprolinuria (HP:0003080)3.46986596
29Hyperglycinuria (HP:0003108)3.41306709
30Abnormality of complement system (HP:0005339)3.27637417
31Joint hemorrhage (HP:0005261)3.26779088
32Abnormality of glycine metabolism (HP:0010895)3.17301172
33Abnormality of serine family amino acid metabolism (HP:0010894)3.17301172
34Distal lower limb muscle weakness (HP:0009053)3.16173740
35Premature rupture of membranes (HP:0001788)3.11068430
36Abnormality of liposaccharide metabolism (HP:0010968)3.03988740
37Abnormality of glycosphingolipid metabolism (HP:0004343)3.03988740
38Abnormality of glycolipid metabolism (HP:0010969)3.03988740
39Hyperbilirubinemia (HP:0002904)3.00705780
40Ocular albinism (HP:0001107)3.00467241
41Poikilocytosis (HP:0004447)2.97907364
42Distal lower limb amyotrophy (HP:0008944)2.97328482
43Amyloidosis (HP:0011034)2.97304265
44Increased connective tissue (HP:0009025)2.96984558
45Hypoglycemic coma (HP:0001325)2.96294674
46Abnormality of the intrinsic pathway (HP:0010989)2.95018113
47Ketosis (HP:0001946)2.93322947
48Distal upper limb amyotrophy (HP:0007149)2.92324083
49Upper limb amyotrophy (HP:0009129)2.92324083
50Systemic lupus erythematosus (HP:0002725)2.92286167
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.85356726
52White forelock (HP:0002211)2.84795704
53Right ventricular cardiomyopathy (HP:0011663)2.81643795
54Myocardial infarction (HP:0001658)2.80940921
55Esophageal varix (HP:0002040)2.80827256
56Abnormality of pyrimidine metabolism (HP:0004353)2.79213190
57Steatorrhea (HP:0002570)2.76678452
58Abnormality of methionine metabolism (HP:0010901)2.74759850
59Abnormality of fatty-acid metabolism (HP:0004359)2.72949614
60Achilles tendon contracture (HP:0001771)2.71070686
61Polycythemia (HP:0001901)2.70831718
62Cerebral aneurysm (HP:0004944)2.67857677
63Abnormality of nucleobase metabolism (HP:0010932)2.64967872
64Autoimmune thrombocytopenia (HP:0001973)2.64807247
65J-shaped sella turcica (HP:0002680)2.63620780
66Abnormality of purine metabolism (HP:0004352)2.57845213
67Abnormality of the distal phalanges of the toes (HP:0010182)2.55888452
68Increased mean platelet volume (HP:0011877)2.53919257
69Spontaneous abortion (HP:0005268)2.51646947
70Osteolytic defects of the hand bones (HP:0009699)2.49822477
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.49822477
72Hand muscle atrophy (HP:0009130)2.48903739
73Dysostosis multiplex (HP:0000943)2.48692948
74Vascular calcification (HP:0004934)2.45580022
75Flat acetabular roof (HP:0003180)2.44901750
76Hyperacusis (HP:0010780)2.42394083
77Short nail (HP:0001799)2.42057159
78Hepatocellular carcinoma (HP:0001402)2.39694760
79Hyperglycinemia (HP:0002154)2.39601082
80Gingival bleeding (HP:0000225)2.39185982
81Metabolic acidosis (HP:0001942)2.38939041
82Abnormality of the Achilles tendon (HP:0005109)2.37298659
83Skin nodule (HP:0200036)2.35742526
84Abnormal platelet volume (HP:0011876)2.35560179
85Patchy hypopigmentation of hair (HP:0011365)2.35007741
86Late onset (HP:0003584)2.34734853
87Cerebral inclusion bodies (HP:0100314)2.34394313
88Broad face (HP:0000283)2.29949046
89Centrally nucleated skeletal muscle fibers (HP:0003687)2.27506129
90Increased cerebral lipofuscin (HP:0011813)2.26975449
91Loss of speech (HP:0002371)2.26161096
92Reticulocytosis (HP:0001923)2.26076250
93Iris hypopigmentation (HP:0007730)2.25691807
94Abnormality of transition element cation homeostasis (HP:0011030)2.24174912
95Cardiovascular calcification (HP:0011915)2.23459851
96Glomerulonephritis (HP:0000099)2.21011833
97Ketoacidosis (HP:0001993)2.20860202
98Abnormality of iron homeostasis (HP:0011031)2.18839793
99Cervical subluxation (HP:0003308)2.17156069
100Peripheral hypomyelination (HP:0007182)2.15388078
101Abdominal distention (HP:0003270)2.13727600
102Hypopigmentation of the fundus (HP:0007894)2.11190246
103Spastic diplegia (HP:0001264)2.10749466
104Neurofibrillary tangles (HP:0002185)2.10595760
105Spinal cord compression (HP:0002176)2.10095662
106Pancreatitis (HP:0001733)2.09244766
107Wormian bones (HP:0002645)2.07513246
108Cholelithiasis (HP:0001081)2.07503105
109Abnormal gallbladder morphology (HP:0012437)2.06515379
110Elbow flexion contracture (HP:0002987)2.05618588
111Abnormality of carpal bone ossification (HP:0006257)2.05198433
112Abnormality of dicarboxylic acid metabolism (HP:0010995)2.04913939
113Dicarboxylic aciduria (HP:0003215)2.04913939
114Interstitial pulmonary disease (HP:0006530)2.04583933
115Ulnar bowing (HP:0003031)2.04109044
116Mesangial abnormality (HP:0001966)2.03639244
117Hemorrhage of the eye (HP:0011885)2.03590077
118Cholecystitis (HP:0001082)2.03270232
119Abnormal gallbladder physiology (HP:0012438)2.03270232
120Delayed CNS myelination (HP:0002188)2.02294955
121Hypoplasia of the iris (HP:0007676)2.01992233
122Eczematoid dermatitis (HP:0000976)2.01075366
123Nephritis (HP:0000123)2.00472516
124Pustule (HP:0200039)2.00144398
125Peritonitis (HP:0002586)1.99952502
126Recurrent gram-negative bacterial infections (HP:0005420)1.99748312
127Abnormal platelet function (HP:0011869)1.98346061
128Impaired platelet aggregation (HP:0003540)1.98346061
129Thrombophlebitis (HP:0004418)1.98082370
130Heterochromia iridis (HP:0001100)1.97687772
131Abnormal cartilage morphology (HP:0002763)1.97524761
132Cellulitis (HP:0100658)1.97475865
133Pigmentary retinal degeneration (HP:0001146)1.96924854
134Relative macrocephaly (HP:0004482)1.95425724
135Increased serum ferritin (HP:0003281)1.95323014
136Lower limb amyotrophy (HP:0007210)1.93108379
137Blue sclerae (HP:0000592)1.92866442
138Sensorimotor neuropathy (HP:0007141)1.92248403
139Coxa vara (HP:0002812)1.91075115
140Increased neuronal autofluorescent lipopigment (HP:0002074)1.89750605
141Ragged-red muscle fibers (HP:0003200)1.89457606
142Urinary glycosaminoglycan excretion (HP:0003541)1.89248380
143Mucopolysacchariduria (HP:0008155)1.89248380
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88414445
145Abnormality of polysaccharide metabolism (HP:0011012)1.88414445
146Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88414445
147Spastic paraparesis (HP:0002313)1.87977887
148Menorrhagia (HP:0000132)1.87086905
149Abnormal ossification of hand bones (HP:0005921)1.86808572
150Nonimmune hydrops fetalis (HP:0001790)1.86561382
151Nuclear cataract (HP:0100018)1.86488451
152Abnormality of vitamin metabolism (HP:0100508)1.84773847
153Nephrolithiasis (HP:0000787)1.84612170
154Blue irides (HP:0000635)1.84365515
155Growth hormone excess (HP:0000845)1.83025832
156Gastrointestinal dysmotility (HP:0002579)1.82897549
157Cupped ribs (HP:0000887)1.82531599
158Bone pain (HP:0002653)1.82525745
159Increased variability in muscle fiber diameter (HP:0003557)1.81504778
160Trismus (HP:0000211)1.81100818
161Segmental peripheral demyelination/remyelination (HP:0003481)1.80645875
162Paraparesis (HP:0002385)1.79974240
163Irritability (HP:0000737)1.79679499
164Purpura (HP:0000979)1.79421720
165Hypertriglyceridemia (HP:0002155)1.79390050
166Abnormality of macrophages (HP:0004311)1.79038016
167Thin bony cortex (HP:0002753)1.77757962
168Axonal loss (HP:0003447)1.77197810
169Nausea (HP:0002018)1.76773630
170Spinal rigidity (HP:0003306)1.74846313
171Aneurysm (HP:0002617)1.74736228
172Asymmetry of the thorax (HP:0001555)1.74715400
173Fragile skin (HP:0001030)1.74709283
174Stridor (HP:0010307)1.73595053
175Fatigue (HP:0012378)1.73439308
176Hypoglycemic seizures (HP:0002173)1.72662789
177Bulbar palsy (HP:0001283)1.72244942
178Pathologic fracture (HP:0002756)1.72202336
179Abnormality of the thoracic spine (HP:0100711)1.71873829
180Difficulty climbing stairs (HP:0003551)1.71235390
181Hepatosplenomegaly (HP:0001433)1.70740405
182Hypochromic microcytic anemia (HP:0004840)1.70580113
183Generalized amyotrophy (HP:0003700)1.70309193
184Aplasia/Hypoplasia of the macula (HP:0008059)1.69061338
185Decreased motor nerve conduction velocity (HP:0003431)1.68483083
186Asymmetric septal hypertrophy (HP:0001670)1.67266438
187Abnormality of skeletal muscle fiber size (HP:0012084)1.67167542
188Flattened epiphyses (HP:0003071)1.67130511
189Abnormality of the umbilical cord (HP:0010881)1.66985449
190Deformed sella turcica (HP:0002681)1.65926765
191Mitral regurgitation (HP:0001653)1.64827008
192Mitral stenosis (HP:0001718)1.64753028
193Mildly elevated creatine phosphokinase (HP:0008180)1.64509269
194Petechiae (HP:0000967)1.64467948
195Hyperparathyroidism (HP:0000843)1.63482553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.27969357
2MST1R3.67881681
3PRPF4B3.49580336
4NME23.44246882
5FRK3.38462759
6RIPK13.07427039
7BCKDK2.77827025
8FGFR42.62160909
9PTK62.61751153
10EPHB12.56382770
11LMTK22.46473209
12GRK62.44078527
13TAOK22.39485786
14PKN22.26736374
15TRIB32.18658197
16SMG12.17742703
17MST42.17656744
18PRKG22.15658514
19SIK12.15409605
20TYK21.93656112
21MAP2K21.82440930
22TAOK31.77855359
23TBK11.74212588
24MAP3K101.59430794
25MET1.58890067
26KDR1.53348766
27MAP4K11.50533712
28MAPK111.46370627
29STK101.43630262
30FLT31.43077594
31CSK1.42065346
32ARAF1.40022657
33CDK121.34217626
34RIPK41.30387385
35TTN1.29596125
36MAP3K111.27432740
37EPHA21.26450509
38PRKD21.20934836
39MAP2K31.19423968
40BMX1.18110942
41MYLK1.16318895
42LRRK21.15517586
43PTK21.12400116
44TGFBR21.10436529
45PAK41.07456520
46IRAK40.98915929
47PRKAA20.98657894
48LIMK10.97034181
49CDC42BPA0.95598635
50MAP3K70.95426149
51MAP3K60.93674674
52SCYL20.91828213
53JAK10.91118131
54JAK20.90706694
55TIE10.90393355
56JAK30.89681862
57MAP2K60.89445259
58PRKD30.89179257
59MOS0.88443433
60MAP3K30.87377515
61MAP3K20.85896545
62MARK20.84630280
63MATK0.84462586
64IRAK20.83250510
65MAPKAPK30.82854005
66LATS20.82583339
67IKBKE0.82320148
68ERBB40.81428964
69NEK90.81302922
70BLK0.80688399
71MTOR0.80535301
72MAP3K80.77482039
73RPS6KB20.77032612
74ERBB20.76730962
75MAP3K140.76707854
76ILK0.76420156
77ZAP700.74103285
78RPS6KA20.73719181
79CDK70.73136955
80MAP2K10.72835983
81KIT0.72274212
82EEF2K0.71356084
83MAP3K10.71122382
84NTRK10.67902320
85CSF1R0.67324763
86TESK10.67307830
87MAP3K130.67251039
88BTK0.67208535
89EPHB20.66698467
90BRAF0.66020434
91ITK0.64921298
92PIK3CG0.64158642
93CDK60.63164618
94INSRR0.60097189
95TESK20.59948862
96PIK3CA0.59090417
97MAPK40.58862322
98SIK30.58739130
99DDR20.57192837
100TAOK10.56060769
101IRAK30.54738653
102RPS6KL10.53255606
103RPS6KC10.53255606
104GRK10.52858942
105NUAK10.52635167
106PDPK10.52214098
107DYRK1B0.51895725
108LATS10.51384617
109PRKD10.49270105
110DMPK0.48547755
111STK380.47895462
112MARK30.47317465
113HIPK20.46990277
114STK30.46909461
115PIM20.46402163
116ABL20.46251405
117KSR20.44907835
118GSK3A0.44845010
119TGFBR10.43778370
120ICK0.43526657
121PDGFRB0.42902977
122MAPKAPK20.42497335
123FGFR30.42162206
124RET0.41878487
125TRPM70.41648195
126PAK10.40762403
127PRKACG0.40187545
128CDK80.38799392
129CAMK1D0.38775480
130FGR0.38683223
131EPHA30.37562551
132DAPK10.37186158
133AKT20.37017306
134MAPK120.36568074
135ACVR1B0.36479974
136ROCK20.35535060
137PDK10.34996455
138EGFR0.34853828
139PRKCQ0.34662506
140FER0.34564965
141RAF10.34375678
142CAMK2G0.33873144
143IGF1R0.33226425
144TEC0.32664205
145PDK20.32637240
146PDGFRA0.32606621
147CHUK0.31645843

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.32028092
2Nitrogen metabolism_Homo sapiens_hsa009103.17669365
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.09962618
4Fat digestion and absorption_Homo sapiens_hsa049753.03583338
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.97070997
6Caffeine metabolism_Homo sapiens_hsa002322.77455601
7Arginine biosynthesis_Homo sapiens_hsa002202.55341617
8Fatty acid degradation_Homo sapiens_hsa000712.40414138
9Tryptophan metabolism_Homo sapiens_hsa003802.40139763
10Complement and coagulation cascades_Homo sapiens_hsa046102.25926111
11Histidine metabolism_Homo sapiens_hsa003402.23461642
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.21714797
13PPAR signaling pathway_Homo sapiens_hsa033202.13516125
14Acute myeloid leukemia_Homo sapiens_hsa052212.08128836
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06773526
16Sulfur metabolism_Homo sapiens_hsa009202.03674211
17Vitamin digestion and absorption_Homo sapiens_hsa049772.02549873
18Bile secretion_Homo sapiens_hsa049762.02481749
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01931738
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00888545
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93812456
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91111461
23Chronic myeloid leukemia_Homo sapiens_hsa052201.87482195
24Starch and sucrose metabolism_Homo sapiens_hsa005001.86979781
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86611542
26Folate biosynthesis_Homo sapiens_hsa007901.85080189
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79182114
28Lysosome_Homo sapiens_hsa041421.73701960
29Chemical carcinogenesis_Homo sapiens_hsa052041.70895303
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70732777
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.70406377
32Peroxisome_Homo sapiens_hsa041461.68660136
33Fatty acid metabolism_Homo sapiens_hsa012121.68517096
34Staphylococcus aureus infection_Homo sapiens_hsa051501.68175492
35Renin-angiotensin system_Homo sapiens_hsa046141.65147435
36Non-small cell lung cancer_Homo sapiens_hsa052231.63115309
37Pancreatic cancer_Homo sapiens_hsa052121.62323309
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.61734291
39Osteoclast differentiation_Homo sapiens_hsa043801.61104550
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.59561988
41VEGF signaling pathway_Homo sapiens_hsa043701.53902232
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.52121159
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48468529
44beta-Alanine metabolism_Homo sapiens_hsa004101.47481940
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43093591
46Butanoate metabolism_Homo sapiens_hsa006501.41705729
47Retinol metabolism_Homo sapiens_hsa008301.41217626
48Propanoate metabolism_Homo sapiens_hsa006401.39179024
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38990095
50Mineral absorption_Homo sapiens_hsa049781.34792874
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33947953
52Endometrial cancer_Homo sapiens_hsa052131.32890524
53Small cell lung cancer_Homo sapiens_hsa052221.31639477
54ABC transporters_Homo sapiens_hsa020101.29311134
55Thyroid cancer_Homo sapiens_hsa052161.27856533
56Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27609556
57Selenocompound metabolism_Homo sapiens_hsa004501.23490820
58Galactose metabolism_Homo sapiens_hsa000521.23055523
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22066378
60Pyruvate metabolism_Homo sapiens_hsa006201.20389647
61Steroid biosynthesis_Homo sapiens_hsa001001.19889246
62Glutathione metabolism_Homo sapiens_hsa004801.17543371
63Vibrio cholerae infection_Homo sapiens_hsa051101.16038744
64Focal adhesion_Homo sapiens_hsa045101.15939777
65Fatty acid elongation_Homo sapiens_hsa000621.15907810
66mTOR signaling pathway_Homo sapiens_hsa041501.15063812
67Notch signaling pathway_Homo sapiens_hsa043301.14414626
68Maturity onset diabetes of the young_Homo sapiens_hsa049501.12376362
69Endocytosis_Homo sapiens_hsa041441.11293141
70TNF signaling pathway_Homo sapiens_hsa046681.10860528
71Shigellosis_Homo sapiens_hsa051311.10692276
72Hepatitis B_Homo sapiens_hsa051611.10533555
73Neurotrophin signaling pathway_Homo sapiens_hsa047221.10026382
74Salmonella infection_Homo sapiens_hsa051321.10002367
75Apoptosis_Homo sapiens_hsa042101.09869141
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09264430
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08722098
78Cyanoamino acid metabolism_Homo sapiens_hsa004601.08051928
79Renal cell carcinoma_Homo sapiens_hsa052111.07639680
80Glycerolipid metabolism_Homo sapiens_hsa005611.05632215
81ErbB signaling pathway_Homo sapiens_hsa040121.05620801
82Carbon metabolism_Homo sapiens_hsa012001.05224183
83Phenylalanine metabolism_Homo sapiens_hsa003601.03775285
84Toxoplasmosis_Homo sapiens_hsa051451.01453512
85Arginine and proline metabolism_Homo sapiens_hsa003301.00989947
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00949754
87Biosynthesis of amino acids_Homo sapiens_hsa012301.00235300
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00052891
89B cell receptor signaling pathway_Homo sapiens_hsa046620.97994788
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97938111
91Glioma_Homo sapiens_hsa052140.97108505
92Proteoglycans in cancer_Homo sapiens_hsa052050.96257513
93Insulin signaling pathway_Homo sapiens_hsa049100.95013828
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94019236
95Malaria_Homo sapiens_hsa051440.93457880
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92747878
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91446512
98Tuberculosis_Homo sapiens_hsa051520.91133275
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91061308
100ECM-receptor interaction_Homo sapiens_hsa045120.90819864
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88765774
102Influenza A_Homo sapiens_hsa051640.88430187
103Pentose phosphate pathway_Homo sapiens_hsa000300.88130076
104Tyrosine metabolism_Homo sapiens_hsa003500.87560574
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.85537376
106Fatty acid biosynthesis_Homo sapiens_hsa000610.85474008
107Prolactin signaling pathway_Homo sapiens_hsa049170.84661144
108Fructose and mannose metabolism_Homo sapiens_hsa000510.83295233
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82419384
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82292628
111Sulfur relay system_Homo sapiens_hsa041220.81907682
112HIF-1 signaling pathway_Homo sapiens_hsa040660.81222216
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80680239
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80419026
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.79997190
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.78186929
117Protein digestion and absorption_Homo sapiens_hsa049740.75619450
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.75063894
119Phagosome_Homo sapiens_hsa041450.74013117
120GnRH signaling pathway_Homo sapiens_hsa049120.73594157
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72873659
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70701902
123Viral carcinogenesis_Homo sapiens_hsa052030.70342370
124Inositol phosphate metabolism_Homo sapiens_hsa005620.70122500
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68682950
126N-Glycan biosynthesis_Homo sapiens_hsa005100.66303208
127Estrogen signaling pathway_Homo sapiens_hsa049150.65055460
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64829253
129Lysine degradation_Homo sapiens_hsa003100.64334157
130Platelet activation_Homo sapiens_hsa046110.63257163
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63219268
132Prostate cancer_Homo sapiens_hsa052150.63100870
133Adherens junction_Homo sapiens_hsa045200.63072761
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62317527
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61932638
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61896302
137Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61805586
138Dilated cardiomyopathy_Homo sapiens_hsa054140.61041672
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60046150
140AMPK signaling pathway_Homo sapiens_hsa041520.59692890
141Measles_Homo sapiens_hsa051620.59363597
142Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57105124
143HTLV-I infection_Homo sapiens_hsa051660.54132663
144Choline metabolism in cancer_Homo sapiens_hsa052310.54043919
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53209152
146MicroRNAs in cancer_Homo sapiens_hsa052060.50632732
147Herpes simplex infection_Homo sapiens_hsa051680.48603929
148Colorectal cancer_Homo sapiens_hsa052100.48471731
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47541099
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47298391
151* Metabolic pathways_Homo sapiens_hsa011000.38901843
152Linoleic acid metabolism_Homo sapiens_hsa005910.38514768
153Glycerophospholipid metabolism_Homo sapiens_hsa005640.37004408
154Vitamin B6 metabolism_Homo sapiens_hsa007500.29803424
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.28006563
156Insulin resistance_Homo sapiens_hsa049310.26494224
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22500094
158Pertussis_Homo sapiens_hsa051330.19830057
159Hepatitis C_Homo sapiens_hsa051600.17052166
160African trypanosomiasis_Homo sapiens_hsa051430.15971147
161Arachidonic acid metabolism_Homo sapiens_hsa005900.15717359
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14694170
163Thyroid hormone synthesis_Homo sapiens_hsa049180.11511359
164Leukocyte transendothelial migration_Homo sapiens_hsa046700.09151110
165One carbon pool by folate_Homo sapiens_hsa006700.09135233
166Ovarian steroidogenesis_Homo sapiens_hsa049130.08640578
167Glycosaminoglycan degradation_Homo sapiens_hsa005310.06728545
168Sphingolipid metabolism_Homo sapiens_hsa006000.06404912
169Amoebiasis_Homo sapiens_hsa051460.05905135
170Legionellosis_Homo sapiens_hsa051340.05627823
171Other glycan degradation_Homo sapiens_hsa005110.05031343
172Leishmaniasis_Homo sapiens_hsa051400.05002823
173Intestinal immune network for IgA production_Homo sapiens_hsa046720.03592888
174Bladder cancer_Homo sapiens_hsa052190.03312765
175Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01687691
176* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.01383901
177Prion diseases_Homo sapiens_hsa050200.01182921

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