ST3GAL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.93047421
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.93047421
3L-phenylalanine metabolic process (GO:0006558)5.61795166
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.61795166
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.55892316
6aromatic amino acid family catabolic process (GO:0009074)5.23928191
7high-density lipoprotein particle remodeling (GO:0034375)4.89531567
8alpha-linolenic acid metabolic process (GO:0036109)4.83749483
9bile acid biosynthetic process (GO:0006699)4.75973731
10peptidyl-glutamic acid carboxylation (GO:0017187)4.69210288
11protein carboxylation (GO:0018214)4.69210288
12kynurenine metabolic process (GO:0070189)4.67731188
13urea cycle (GO:0000050)4.61397683
14urea metabolic process (GO:0019627)4.61397683
15indole-containing compound catabolic process (GO:0042436)4.58138427
16indolalkylamine catabolic process (GO:0046218)4.58138427
17tryptophan catabolic process (GO:0006569)4.58138427
18negative regulation of fibrinolysis (GO:0051918)4.57758913
19complement activation, alternative pathway (GO:0006957)4.51600958
20regulation of fibrinolysis (GO:0051917)4.42649657
21reverse cholesterol transport (GO:0043691)4.36424732
22tryptophan metabolic process (GO:0006568)4.32670157
23regulation of protein activation cascade (GO:2000257)4.31916678
24nitrogen cycle metabolic process (GO:0071941)4.22400939
25glyoxylate metabolic process (GO:0046487)4.14475189
26protein-lipid complex remodeling (GO:0034368)4.14002365
27macromolecular complex remodeling (GO:0034367)4.14002365
28plasma lipoprotein particle remodeling (GO:0034369)4.14002365
29regulation of cholesterol esterification (GO:0010872)4.13822528
30cysteine metabolic process (GO:0006534)4.08958966
31plasma lipoprotein particle clearance (GO:0034381)4.07605672
32regulation of triglyceride catabolic process (GO:0010896)4.07457404
33bile acid metabolic process (GO:0008206)4.04194498
34cellular ketone body metabolic process (GO:0046950)4.01424625
35regulation of complement activation (GO:0030449)4.01257914
36phospholipid efflux (GO:0033700)3.99330719
37lysine metabolic process (GO:0006553)3.97946277
38lysine catabolic process (GO:0006554)3.97946277
39cholesterol efflux (GO:0033344)3.93208829
40dicarboxylic acid biosynthetic process (GO:0043650)3.89668680
41triglyceride homeostasis (GO:0070328)3.80410555
42acylglycerol homeostasis (GO:0055090)3.80410555
43glutamate metabolic process (GO:0006536)3.77033212
44fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.76776086
45tyrosine metabolic process (GO:0006570)3.76277796
46protoporphyrinogen IX metabolic process (GO:0046501)3.74721348
47plasma lipoprotein particle assembly (GO:0034377)3.70969997
48sulfur amino acid catabolic process (GO:0000098)3.70235720
49negative regulation of cholesterol transport (GO:0032375)3.67081483
50negative regulation of sterol transport (GO:0032372)3.67081483
51aromatic amino acid family metabolic process (GO:0009072)3.66116994
52amino-acid betaine metabolic process (GO:0006577)3.55645058
53positive regulation of lipid catabolic process (GO:0050996)3.54208245
54alpha-amino acid catabolic process (GO:1901606)3.52909782
55very-low-density lipoprotein particle assembly (GO:0034379)3.49990548
56response to methylmercury (GO:0051597)3.48524851
57serine family amino acid catabolic process (GO:0009071)3.45670894
58cofactor catabolic process (GO:0051187)3.45513023
59arginine metabolic process (GO:0006525)3.45166740
60protein-lipid complex assembly (GO:0065005)3.42770463
61ketone body metabolic process (GO:1902224)3.42573939
62synaptic vesicle maturation (GO:0016188)3.37781744
63coenzyme catabolic process (GO:0009109)3.37779396
64plasma lipoprotein particle organization (GO:0071827)3.35308113
65protoporphyrinogen IX biosynthetic process (GO:0006782)3.34890499
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34878422
67negative regulation of lipase activity (GO:0060192)3.34232276
68fibrinolysis (GO:0042730)3.32223620
69opsonization (GO:0008228)3.26980896
70benzene-containing compound metabolic process (GO:0042537)3.26370066
71homocysteine metabolic process (GO:0050667)3.26176311
72drug catabolic process (GO:0042737)3.24766162
73bile acid and bile salt transport (GO:0015721)3.21957795
74protein-lipid complex subunit organization (GO:0071825)3.21234956
75low-density lipoprotein particle remodeling (GO:0034374)3.20939982
76cellular amino acid catabolic process (GO:0009063)3.19822055
77phospholipid homeostasis (GO:0055091)3.18705712
78indolalkylamine metabolic process (GO:0006586)3.18042590
79aldehyde catabolic process (GO:0046185)3.14628278
80cellular modified amino acid catabolic process (GO:0042219)3.11450349
81negative regulation of cell killing (GO:0031342)3.11228334
82negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.11228334
83complement activation (GO:0006956)3.10955546
84blood coagulation, intrinsic pathway (GO:0007597)3.10921127
85regulation of B cell receptor signaling pathway (GO:0050855)3.10866610
86protein activation cascade (GO:0072376)3.09293640
87synaptic vesicle exocytosis (GO:0016079)3.06665663
88cellular glucuronidation (GO:0052695)3.06205661
89complement activation, classical pathway (GO:0006958)3.04178842
90amine catabolic process (GO:0009310)3.02895263
91cellular biogenic amine catabolic process (GO:0042402)3.02895263
92aspartate family amino acid catabolic process (GO:0009068)3.02764858
93imidazole-containing compound metabolic process (GO:0052803)3.02112012
94positive regulation of fatty acid beta-oxidation (GO:0032000)3.02018248
95positive regulation of triglyceride lipase activity (GO:0061365)3.00002607
96positive regulation of lipoprotein lipase activity (GO:0051006)3.00002607
97acute-phase response (GO:0006953)2.97748480
98cholesterol homeostasis (GO:0042632)2.94358868
99sterol homeostasis (GO:0055092)2.90598119
100flavonoid metabolic process (GO:0009812)2.90383127
101heme transport (GO:0015886)2.90165398
102cellular potassium ion homeostasis (GO:0030007)2.89872691
103exogenous drug catabolic process (GO:0042738)2.89774638
104glutamate secretion (GO:0014047)2.87033790
105pyridine nucleotide biosynthetic process (GO:0019363)2.86362351
106nicotinamide nucleotide biosynthetic process (GO:0019359)2.86362351
107short-chain fatty acid metabolic process (GO:0046459)2.86278131
108ethanol oxidation (GO:0006069)2.83523756
109membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.80258736
110synaptic vesicle docking involved in exocytosis (GO:0016081)2.76761250
111positive regulation of Rap GTPase activity (GO:0032854)2.73873612
112nerve growth factor signaling pathway (GO:0038180)2.66032608
113regulation of synaptic vesicle exocytosis (GO:2000300)2.60601827
114production of molecular mediator involved in inflammatory response (GO:0002532)2.60478245
115macrophage activation involved in immune response (GO:0002281)2.48939945
116L-amino acid import (GO:0043092)2.48140193
117regulation of Rap GTPase activity (GO:0032317)2.47735385
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45922111
119activated T cell proliferation (GO:0050798)2.44166451
120locomotory exploration behavior (GO:0035641)2.40496991
121regulation of synaptic vesicle transport (GO:1902803)2.36915499
122axon ensheathment in central nervous system (GO:0032291)2.35122314
123central nervous system myelination (GO:0022010)2.35122314
124positive regulation of neurotransmitter secretion (GO:0001956)2.34337159
125adaptation of signaling pathway (GO:0023058)2.25655323
126positive regulation of gamma-delta T cell activation (GO:0046645)2.25651539
127regulation of short-term neuronal synaptic plasticity (GO:0048172)2.25193654
128regulation of ARF protein signal transduction (GO:0032012)2.24936583
129cellular response to thyroid hormone stimulus (GO:0097067)2.23284835
130microglial cell activation (GO:0001774)2.16767157
131potassium ion homeostasis (GO:0055075)2.15114007
132positive regulation of macrophage cytokine production (GO:0060907)2.12605477
133regulation of synapse structural plasticity (GO:0051823)2.12489273
134potassium ion import (GO:0010107)2.10995323
135positive regulation of cellular amide metabolic process (GO:0034250)2.10023883
136positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.09143915
137regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.07817277
138ionotropic glutamate receptor signaling pathway (GO:0035235)2.07749466
139sodium ion export (GO:0071436)2.06575911
140positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.06417797
141antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.05576264
142regulation of beta-amyloid formation (GO:1902003)2.05411472
143negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.04119428
144synaptic transmission, glutamatergic (GO:0035249)2.04076618
145eosinophil chemotaxis (GO:0048245)2.03652448
146antigen processing and presentation of endogenous antigen (GO:0019883)2.03274334
147regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.02334924
148regulation of T cell tolerance induction (GO:0002664)2.02189350
149chondroitin sulfate catabolic process (GO:0030207)2.02140747
150macroautophagy (GO:0016236)2.01745842
151proline transport (GO:0015824)2.00786701
152positive regulation of neurotransmitter transport (GO:0051590)2.00574750
153neuronal action potential propagation (GO:0019227)1.98124968
154neurotransmitter secretion (GO:0007269)1.97481915
155regulation of macrophage chemotaxis (GO:0010758)1.96610108
156positive regulation of calcium ion-dependent exocytosis (GO:0045956)1.96210149
157interferon-gamma-mediated signaling pathway (GO:0060333)1.95925570
158clathrin coat assembly (GO:0048268)1.95027192
159cellular response to nerve growth factor stimulus (GO:1990090)1.94942447
160response to nerve growth factor (GO:1990089)1.94942447
161cellular extravasation (GO:0045123)1.94868878
162* ganglioside metabolic process (GO:0001573)1.93133735
163negative regulation of interleukin-12 production (GO:0032695)1.92689277
164regulation of neuronal synaptic plasticity (GO:0048168)1.92175610
165exploration behavior (GO:0035640)1.91074444
166regulation of natural killer cell mediated cytotoxicity (GO:0042269)1.90245003
167regulation of natural killer cell mediated immunity (GO:0002715)1.90245003
168antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.89861922
169macrophage activation (GO:0042116)1.89055056
170cerebellar Purkinje cell differentiation (GO:0021702)1.88702149
171positive regulation of synaptic transmission, dopaminergic (GO:0032226)1.88059047
172phagosome maturation (GO:0090382)1.86916184
173positive regulation of antigen processing and presentation (GO:0002579)1.86202705
174barbed-end actin filament capping (GO:0051016)1.85343518
175neuron-neuron synaptic transmission (GO:0007270)1.85186907
176cellular sodium ion homeostasis (GO:0006883)1.84776143
177signal complex assembly (GO:0007172)1.84653898
178gonadal mesoderm development (GO:0007506)1.84597213
179regulation of neurotransmitter secretion (GO:0046928)1.84213894
180amino sugar catabolic process (GO:0046348)1.83854625
181detection of calcium ion (GO:0005513)1.83153117
182neurotransmitter-gated ion channel clustering (GO:0072578)1.81320836
183negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.80554786
184regulation of respiratory gaseous exchange by neurological system process (GO:0002087)1.80098452
185regulation of macrophage cytokine production (GO:0010935)1.79875838
186neuromuscular process controlling posture (GO:0050884)1.79651476
187postsynaptic membrane organization (GO:0001941)1.79537884
188negative regulation of bone resorption (GO:0045779)1.78741520
189pigment cell differentiation (GO:0050931)1.78604570
190positive thymic T cell selection (GO:0045059)1.78504229
191eosinophil migration (GO:0072677)1.77650138
192keratan sulfate catabolic process (GO:0042340)1.76576623
193regulation of mononuclear cell migration (GO:0071675)1.76209147
194T cell migration (GO:0072678)1.75135375
195myeloid cell activation involved in immune response (GO:0002275)1.74629561
196regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)1.74199566
197regulation of calcium-mediated signaling (GO:0050848)1.74098161
198regulation of synaptic plasticity (GO:0048167)1.73580789
199long-term synaptic potentiation (GO:0060291)1.73392935
200regulation of type 2 immune response (GO:0002828)1.73086353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.16714631
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.72562203
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.74583593
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.56216371
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.22735509
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.01538614
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.10645696
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.09015633
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.75731302
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.59760121
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.47927322
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.36404991
13GATA1_22025678_ChIP-Seq_K562_Human2.33771975
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.04494114
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.00638364
16EZH2_22144423_ChIP-Seq_EOC_Human1.86976191
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.66059482
18RUNX_20019798_ChIP-Seq_JUKART_Human1.59563756
19GBX2_23144817_ChIP-Seq_PC3_Human1.56846514
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55360232
21GATA1_19941826_ChIP-Seq_K562_Human1.54165683
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53038403
23VDR_24787735_ChIP-Seq_THP-1_Human1.46862087
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.46406847
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42391986
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40760316
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37510166
28* GATA1_19941827_ChIP-Seq_MEL_Mouse1.36452430
29* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.36427776
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35682870
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34410794
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.32001251
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31832234
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26691318
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25644963
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.23081773
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.22678718
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21192157
39REST_21632747_ChIP-Seq_MESCs_Mouse1.20525692
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20072384
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.18690349
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.17319521
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15513085
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14574308
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14164346
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13949494
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.13029351
48GATA2_19941826_ChIP-Seq_K562_Human1.10902308
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10415159
50HTT_18923047_ChIP-ChIP_STHdh_Human1.10297319
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09655916
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09655916
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09003740
54KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.08535464
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07590725
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07590725
57REST_18959480_ChIP-ChIP_MESCs_Mouse1.07261649
58DROSHA_22980978_ChIP-Seq_HELA_Human1.06392310
59* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05604579
60* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05316102
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03766476
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.03548647
63SPI1_23127762_ChIP-Seq_K562_Human1.03165280
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01594341
65SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00696065
66JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00682316
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00102764
68JARID2_20075857_ChIP-Seq_MESCs_Mouse0.99519661
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97463726
70HNF4A_19822575_ChIP-Seq_HepG2_Human0.97094813
71* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97083747
72AHR_22903824_ChIP-Seq_MCF-7_Human0.96886551
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96813249
74CLOCK_20551151_ChIP-Seq_293T_Human0.95087688
75EZH2_27294783_Chip-Seq_ESCs_Mouse0.93518337
76SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91876195
77IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91354467
78EP300_21415370_ChIP-Seq_HL-1_Mouse0.90416312
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90342469
80LXR_22292898_ChIP-Seq_THP-1_Human0.90076267
81TAF15_26573619_Chip-Seq_HEK293_Human0.89683471
82GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.89292424
83EZH2_27304074_Chip-Seq_ESCs_Mouse0.89145389
84EED_16625203_ChIP-ChIP_MESCs_Mouse0.87454152
85ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86857572
86CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86427280
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.86276270
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86189190
89ARNT_22903824_ChIP-Seq_MCF-7_Human0.86079488
90* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85276131
91AR_21572438_ChIP-Seq_LNCaP_Human0.85203765
92NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85019596
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.84747208
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84085554
95* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84061930
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83977499
97MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83697800
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83582052
99* SMAD3_21741376_ChIP-Seq_HESCs_Human0.82768807
100* KDM2B_26808549_Chip-Seq_REH_Human0.82259886
101* IRF8_27001747_Chip-Seq_BMDM_Mouse0.81950311
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81943070
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80707788
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80707788
105* TP53_18474530_ChIP-ChIP_U2OS_Human0.79622584
106BCAT_22108803_ChIP-Seq_LS180_Human0.79191516
107* SMAD3_21741376_ChIP-Seq_EPCs_Human0.78842365
108TCF4_23295773_ChIP-Seq_U87_Human0.78806209
109* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78612720
110SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77977755
111CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77655930
112* STAT3_23295773_ChIP-Seq_U87_Human0.77520181
113SMRT_27268052_Chip-Seq_Bcells_Human0.76922372
114P53_22387025_ChIP-Seq_ESCs_Mouse0.76815876
115IRF8_21731497_ChIP-ChIP_J774_Mouse0.76677594
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.76659740
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75947152
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.73762726
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.73570854
120* KDM2B_26808549_Chip-Seq_K562_Human0.73526098
121SMAD4_21799915_ChIP-Seq_A2780_Human0.73493607
122* SOX2_21211035_ChIP-Seq_LN229_Gbm0.73181662
123* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72160145
124TP53_16413492_ChIP-PET_HCT116_Human0.68410970
125EGR1_19032775_ChIP-ChIP_M12_Human0.67135819
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.66728622
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66476904
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65615236
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.65054253
130* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.64983879
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.64939636
132* SMAD4_21741376_ChIP-Seq_EPCs_Human0.64919385
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64785020
134BP1_19119308_ChIP-ChIP_Hs578T_Human0.63894193
135* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.63687197
136* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63449460
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.63433210
138* AR_25329375_ChIP-Seq_VCAP_Human0.63214381
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.63068619
140* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.62693706
141NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.61644312
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.61391146
143* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.61202689
144AR_19668381_ChIP-Seq_PC3_Human0.60989426
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.60974650
146CTBP1_25329375_ChIP-Seq_LNCAP_Human0.60925323
147P300_19829295_ChIP-Seq_ESCs_Human0.60869087
148RXR_22108803_ChIP-Seq_LS180_Human0.60275801
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.60131738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.76603682
2MP0005360_urolithiasis5.67538431
3MP0005085_abnormal_gallbladder_physiolo5.23127635
4MP0005365_abnormal_bile_salt4.68589585
5MP0008875_abnormal_xenobiotic_pharmacok4.37722380
6MP0003656_abnormal_erythrocyte_physiolo3.42444801
7MP0000569_abnormal_digit_pigmentation3.32321834
8MP0005083_abnormal_biliary_tract3.30000905
9MP0010329_abnormal_lipoprotein_level3.16647039
10MP0003252_abnormal_bile_duct2.98532683
11MP0009840_abnormal_foam_cell2.93777376
12MP0003195_calcinosis2.73752837
13MP0004859_abnormal_synaptic_plasticity2.57331059
14MP0003806_abnormal_nucleotide_metabolis2.55290269
15MP0003191_abnormal_cellular_cholesterol2.45420996
16MP0005332_abnormal_amino_acid2.11807712
17MP0005171_absent_coat_pigmentation2.08138922
18MP0005671_abnormal_response_to2.05130258
19MP0000920_abnormal_myelination2.04825469
20MP0003724_increased_susceptibility_to2.02513863
21MP0000604_amyloidosis1.93937769
22* MP0002118_abnormal_lipid_homeostasis1.88732766
23MP0000609_abnormal_liver_physiology1.80538369
24MP0005423_abnormal_somatic_nervous1.78028548
25MP0005387_immune_system_phenotype1.75974654
26MP0001790_abnormal_immune_system1.75974654
27MP0003329_amyloid_beta_deposits1.75859540
28MP0004147_increased_porphyrin_level1.72556538
29MP0001666_abnormal_nutrient_absorption1.69584417
30MP0009785_altered_susceptibility_to1.66456104
31MP0002837_dystrophic_cardiac_calcinosis1.65450905
32MP0000015_abnormal_ear_pigmentation1.64167256
33MP0005319_abnormal_enzyme/_coenzyme1.62857496
34MP0002148_abnormal_hypersensitivity_rea1.61938272
35MP0002138_abnormal_hepatobiliary_system1.60848716
36MP0005584_abnormal_enzyme/coenzyme_acti1.59113216
37MP0001835_abnormal_antigen_presentation1.55450508
38MP0002419_abnormal_innate_immunity1.53483168
39MP0005000_abnormal_immune_tolerance1.53361532
40MP0005174_abnormal_tail_pigmentation1.51966989
41MP0003075_altered_response_to1.50105381
42MP0008569_lethality_at_weaning1.47656945
43MP0003635_abnormal_synaptic_transmissio1.43665606
44MP0000685_abnormal_immune_system1.41428330
45MP0005025_abnormal_response_to1.39428997
46MP0003868_abnormal_feces_composition1.36509060
47MP0009745_abnormal_behavioral_response1.31322302
48MP0003880_abnormal_central_pattern1.31107661
49MP0003690_abnormal_glial_cell1.28677476
50MP0004019_abnormal_vitamin_homeostasis1.28190677
51MP0001800_abnormal_humoral_immune1.27884938
52MP0002064_seizures1.27680048
53MP0002723_abnormal_immune_serum1.27414243
54MP0001533_abnormal_skeleton_physiology1.26306042
55MP0002452_abnormal_antigen_presenting1.25384023
56MP0001970_abnormal_pain_threshold1.24055118
57MP0002998_abnormal_bone_remodeling1.23554352
58MP0003634_abnormal_glial_cell1.22447857
59MP0003787_abnormal_imprinting1.22349642
60MP0004130_abnormal_muscle_cell1.22247344
61MP0002822_catalepsy1.22239251
62MP0010386_abnormal_urinary_bladder1.21925523
63MP0003300_gastrointestinal_ulcer1.20536171
64MP0000343_altered_response_to1.20236788
65MP0005535_abnormal_body_temperature1.19554714
66MP0009764_decreased_sensitivity_to1.18654786
67MP0002063_abnormal_learning/memory/cond1.18260791
68MP0005310_abnormal_salivary_gland1.15587037
69MP0002420_abnormal_adaptive_immunity1.13224638
70MP0001764_abnormal_homeostasis1.12978117
71MP0009046_muscle_twitch1.11490742
72MP0001819_abnormal_immune_cell1.11091867
73MP0004510_myositis1.11085080
74MP0004885_abnormal_endolymph1.10630169
75MP0005167_abnormal_blood-brain_barrier1.10527181
76MP0001502_abnormal_circadian_rhythm1.10286432
77MP0001986_abnormal_taste_sensitivity1.10245359
78MP0001968_abnormal_touch/_nociception1.08899217
79MP0003183_abnormal_peptide_metabolism1.08712880
80MP0008874_decreased_physiological_sensi1.04076403
81MP0003828_pulmonary_edema1.03524394
82MP0001440_abnormal_grooming_behavior1.02749460
83MP0002736_abnormal_nociception_after1.01610741
84MP0005636_abnormal_mineral_homeostasis1.01409649
85MP0003879_abnormal_hair_cell0.99826885
86MP0001501_abnormal_sleep_pattern0.98820139
87MP0004270_analgesia0.97633243
88MP0001958_emphysema0.96756921
89MP0003045_fibrosis0.96141048
90MP0001905_abnormal_dopamine_level0.94651018
91MP0005451_abnormal_body_composition0.93391104
92MP0005166_decreased_susceptibility_to0.93213128
93MP0002909_abnormal_adrenal_gland0.93189489
94MP0003633_abnormal_nervous_system0.93132140
95MP0001984_abnormal_olfaction0.93126484
96MP0002229_neurodegeneration0.92919537
97MP0002405_respiratory_system_inflammati0.92400617
98MP0000371_diluted_coat_color0.91946567
99MP0005058_abnormal_lysosome_morphology0.91815047
100MP0002971_abnormal_brown_adipose0.91677380
101MP0009780_abnormal_chondrocyte_physiolo0.90831824
102MP0000598_abnormal_liver_morphology0.90072776
103MP0009763_increased_sensitivity_to0.89778808
104MP0001851_eye_inflammation0.89292389
105MP0008872_abnormal_physiological_respon0.89146322
106MP0003303_peritoneal_inflammation0.88196679
107MP0008469_abnormal_protein_level0.87375089
108* MP0002078_abnormal_glucose_homeostasis0.86872944
109MP0002090_abnormal_vision0.86767440
110MP0002572_abnormal_emotion/affect_behav0.85217576
111MP0006036_abnormal_mitochondrial_physio0.83852463
112MP0003705_abnormal_hypodermis_morpholog0.83363350
113MP0001845_abnormal_inflammatory_respons0.81027689
114* MP0009642_abnormal_blood_homeostasis0.80840162
115MP0004858_abnormal_nervous_system0.79876522
116MP0005647_abnormal_sex_gland0.79813786
117MP0009697_abnormal_copulation0.79339378
118MP0003172_abnormal_lysosome_physiology0.79208332
119MP0009643_abnormal_urine_homeostasis0.78933485
120MP0003436_decreased_susceptibility_to0.78825705
121MP0000639_abnormal_adrenal_gland0.78538323
122MP0005595_abnormal_vascular_smooth0.77169150
123MP0005464_abnormal_platelet_physiology0.77043308
124MP0004381_abnormal_hair_follicle0.75713314
125MP0003091_abnormal_cell_migration0.75343865
126MP0002557_abnormal_social/conspecific_i0.75138274
127MP0003186_abnormal_redox_activity0.74910386
128MP0004924_abnormal_behavior0.74530709
129MP0005386_behavior/neurological_phenoty0.74530709
130MP0005448_abnormal_energy_balance0.74004221
131MP0003631_nervous_system_phenotype0.73988511
132MP0002933_joint_inflammation0.73428503
133MP0005075_abnormal_melanosome_morpholog0.73376046
134MP0003448_altered_tumor_morphology0.72073190
135MP0005334_abnormal_fat_pad0.70226141
136MP0002272_abnormal_nervous_system0.68734112
137MP0005376_homeostasis/metabolism_phenot0.68670544
138MP0006082_CNS_inflammation0.65508368
139MP0002876_abnormal_thyroid_physiology0.63289725
140MP0002735_abnormal_chemical_nociception0.61868794
141MP0006035_abnormal_mitochondrial_morpho0.61159489
142MP0002067_abnormal_sensory_capabilities0.59991989
143MP0002734_abnormal_mechanical_nocicepti0.59263264
144MP0002733_abnormal_thermal_nociception0.58658548
145MP0009765_abnormal_xenobiotic_induced0.58070965
146MP0003646_muscle_fatigue0.58020968
147MP0004883_abnormal_blood_vessel0.55567644
148MP0002332_abnormal_exercise_endurance0.54551762
149MP0003638_abnormal_response/metabolism_0.54450163
150MP0001486_abnormal_startle_reflex0.52220952
151MP0004142_abnormal_muscle_tone0.52111164
152MP0010368_abnormal_lymphatic_system0.51975248
153MP0003011_delayed_dark_adaptation0.51847252
154MP0005164_abnormal_response_to0.51637660
155MP0003632_abnormal_nervous_system0.51417716

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.37400100
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.82365461
3Prolonged partial thromboplastin time (HP:0003645)5.27472707
4Xanthomatosis (HP:0000991)5.09550915
5Abnormality of glycolipid metabolism (HP:0010969)5.07359230
6Abnormality of liposaccharide metabolism (HP:0010968)5.07359230
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.07359230
8Intrahepatic cholestasis (HP:0001406)4.99985458
9Hyperlipoproteinemia (HP:0010980)4.88704062
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.87220467
11Hypobetalipoproteinemia (HP:0003563)4.82016924
12Complement deficiency (HP:0004431)4.78021364
13Poikilocytosis (HP:0004447)4.03382136
14Joint hemorrhage (HP:0005261)3.96692676
15Hypolipoproteinemia (HP:0010981)3.77893611
16Cholelithiasis (HP:0001081)3.74038819
17Abnormality of the common coagulation pathway (HP:0010990)3.73481385
18Increased cerebral lipofuscin (HP:0011813)3.66730549
19Dysostosis multiplex (HP:0000943)3.66504226
20Systemic lupus erythematosus (HP:0002725)3.60548947
21Hypoalphalipoproteinemia (HP:0003233)3.59381798
22Abnormal gallbladder morphology (HP:0012437)3.58891830
23Hypochromic microcytic anemia (HP:0004840)3.58525208
24Abnormality of complement system (HP:0005339)3.56174818
25Ketosis (HP:0001946)3.55344661
26Reticulocytosis (HP:0001923)3.55151109
27Acanthocytosis (HP:0001927)3.54213417
28Hyperbilirubinemia (HP:0002904)3.52099598
29Mutism (HP:0002300)3.51307744
30Supranuclear gaze palsy (HP:0000605)3.50426428
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.49103724
32Epidermoid cyst (HP:0200040)3.44213795
33Cholecystitis (HP:0001082)3.43505528
34Abnormal gallbladder physiology (HP:0012438)3.43505528
35Hyperammonemia (HP:0001987)3.42545878
36Action tremor (HP:0002345)3.31397687
37Abnormality of binocular vision (HP:0011514)3.27243726
38Diplopia (HP:0000651)3.27243726
39Atonic seizures (HP:0010819)3.18264335
40Papilledema (HP:0001085)3.16147207
41Abnormality of polysaccharide metabolism (HP:0011012)3.15757691
42Abnormality of glycosaminoglycan metabolism (HP:0004371)3.15757691
43Abnormality of mucopolysaccharide metabolism (HP:0011020)3.15757691
44Increased neuronal autofluorescent lipopigment (HP:0002074)3.15418313
45Abnormality of methionine metabolism (HP:0010901)3.13608075
46Abnormality of sulfur amino acid metabolism (HP:0004339)3.10506611
47Mucopolysacchariduria (HP:0008155)3.09654742
48Urinary glycosaminoglycan excretion (HP:0003541)3.09654742
49Abnormality of macrophages (HP:0004311)3.08737106
50Hemiplegia (HP:0002301)3.07419283
51Febrile seizures (HP:0002373)3.03192195
52Hypercholesterolemia (HP:0003124)3.03063417
53Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00602860
54Recurrent gram-negative bacterial infections (HP:0005420)2.97258485
55Abnormality of the heme biosynthetic pathway (HP:0010472)2.97208838
56Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91339214
57Vacuolated lymphocytes (HP:0001922)2.89388525
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.85722610
59Glomerulonephritis (HP:0000099)2.80567617
60Spontaneous abortion (HP:0005268)2.74916517
61Focal motor seizures (HP:0011153)2.74749774
62Abnormality of the intrinsic pathway (HP:0010989)2.73242603
63Fat malabsorption (HP:0002630)2.72125635
64Hepatocellular carcinoma (HP:0001402)2.71628161
65Hypoglycemic coma (HP:0001325)2.70880084
66Hyperglycinemia (HP:0002154)2.67761795
67Abnormality of the gallbladder (HP:0005264)2.67603551
68Ketoacidosis (HP:0001993)2.65724439
69Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.63698773
70Eczematoid dermatitis (HP:0000976)2.58700524
71Recurrent abscess formation (HP:0002722)2.57509965
72Amyloidosis (HP:0011034)2.54519754
73Skin nodule (HP:0200036)2.52746577
74Increased CSF protein (HP:0002922)2.44855996
75Ocular albinism (HP:0001107)2.42031678
76Metabolic acidosis (HP:0001942)2.39908907
77Abnormality of pyrimidine metabolism (HP:0004353)2.39620647
78Asymmetric septal hypertrophy (HP:0001670)2.39200410
79Recurrent bacterial skin infections (HP:0005406)2.39113610
80Loss of speech (HP:0002371)2.39028785
81Myocardial infarction (HP:0001658)2.38202890
82Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.37736718
83Neuronal loss in central nervous system (HP:0002529)2.36661005
84Mitral stenosis (HP:0001718)2.36565475
85Agitation (HP:0000713)2.36019002
86Pulmonary infiltrates (HP:0002113)2.35586261
87Iris hypopigmentation (HP:0007730)2.35450088
88Conjugated hyperbilirubinemia (HP:0002908)2.34690960
89Disinhibition (HP:0000734)2.32145478
90Peripheral hypomyelination (HP:0007182)2.31821023
91* Status epilepticus (HP:0002133)2.31562748
92Hyperventilation (HP:0002883)2.31193515
93Orchitis (HP:0100796)2.30607373
94Sensorimotor neuropathy (HP:0007141)2.29868748
95Hematochezia (HP:0002573)2.28895866
96Intention tremor (HP:0002080)2.27719058
97Abnormal eating behavior (HP:0100738)2.25847920
98Autoimmune thrombocytopenia (HP:0001973)2.25642821
99Ankle clonus (HP:0011448)2.25544581
100Dialeptic seizures (HP:0011146)2.25273440
101Abnormality of fatty-acid metabolism (HP:0004359)2.25189133
102Spontaneous hematomas (HP:0007420)2.24842166
103Abnormality of nucleobase metabolism (HP:0010932)2.24391748
104Neonatal onset (HP:0003623)2.23179779
105Abnormality of glycine metabolism (HP:0010895)2.21500688
106Abnormality of serine family amino acid metabolism (HP:0010894)2.21500688
107Apathy (HP:0000741)2.18624237
108Akinesia (HP:0002304)2.18530006
109Polyphagia (HP:0002591)2.18340007
110Cerebral inclusion bodies (HP:0100314)2.18221140
111Abnormality of purine metabolism (HP:0004352)2.16777298
112Delayed CNS myelination (HP:0002188)2.14153339
113Diminished motivation (HP:0000745)2.10684363
114Optic neuritis (HP:0100653)2.10307605
115Retrobulbar optic neuritis (HP:0100654)2.10307605
116Neurofibrillary tangles (HP:0002185)2.10297727
117Epileptic encephalopathy (HP:0200134)2.09683596
118Polycythemia (HP:0001901)2.08720317
119Hyperglycinuria (HP:0003108)2.08032315
120Myositis (HP:0100614)2.07888264
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.07523148
122Abnormality of the Achilles tendon (HP:0005109)2.06646046
123Abnormality of iron homeostasis (HP:0011031)2.06408410
124Stomatitis (HP:0010280)2.05352381
125Gout (HP:0001997)2.03528655
126Visual hallucinations (HP:0002367)2.03508608
127Steatorrhea (HP:0002570)2.02445309
128Focal seizures (HP:0007359)2.02245669
129T lymphocytopenia (HP:0005403)2.01524393
130Myokymia (HP:0002411)1.98987400
131Interstitial pulmonary disease (HP:0006530)1.98333432
132Truncal ataxia (HP:0002078)1.98127685
133Nephritis (HP:0000123)1.95848924
134Abnormality of serum amino acid levels (HP:0003112)1.95595582
135Confusion (HP:0001289)1.95068088
136Menorrhagia (HP:0000132)1.94936707
137Abnormality of transition element cation homeostasis (HP:0011030)1.93449961
138Postural instability (HP:0002172)1.93121810
139Axonal loss (HP:0003447)1.92881350
140Albinism (HP:0001022)1.91496244
141Abnormality of T cell number (HP:0011839)1.91228038
142Rapidly progressive (HP:0003678)1.89455023
143Spastic diplegia (HP:0001264)1.89203868
144Hypoglycemic seizures (HP:0002173)1.89185323
145Memory impairment (HP:0002354)1.88553602
146Purpura (HP:0000979)1.88408165
147Mediastinal lymphadenopathy (HP:0100721)1.87887853
148Gingival bleeding (HP:0000225)1.87167948
149Vasculitis (HP:0002633)1.86786310
150Hemorrhage of the eye (HP:0011885)1.86040543
151* Generalized tonic-clonic seizures (HP:0002069)1.84911543
152Recurrent skin infections (HP:0001581)1.84190246
153Retinal atrophy (HP:0001105)1.84096750
154Blue irides (HP:0000635)1.83838303
155Hemoptysis (HP:0002105)1.83626216
156Abnormal social behavior (HP:0012433)1.82030090
157Impaired social interactions (HP:0000735)1.82030090
158Rigidity (HP:0002063)1.81960720
159Dementia (HP:0000726)1.81956688
160Inappropriate behavior (HP:0000719)1.81319559
161Fetal akinesia sequence (HP:0001989)1.81269937
162Increased serum ferritin (HP:0003281)1.80955916
163Thrombophlebitis (HP:0004418)1.78843101
164Cerebral edema (HP:0002181)1.77512106
165Progressive cerebellar ataxia (HP:0002073)1.77372012
166Generalized hypopigmentation (HP:0007513)1.76453093
167Vascular calcification (HP:0004934)1.76263669
168Progressive neurologic deterioration (HP:0002344)1.76256625
169Absence seizures (HP:0002121)1.75621431
170Pulmonary embolism (HP:0002204)1.73120933
171Hemiparesis (HP:0001269)1.72718355
172* Irritability (HP:0000737)1.72513995
173Torticollis (HP:0000473)1.72075477
174Poor eye contact (HP:0000817)1.71779325
175* Global brain atrophy (HP:0002283)1.71700539
176Chronic mucocutaneous candidiasis (HP:0002728)1.71627667
177Recurrent cutaneous fungal infections (HP:0011370)1.71627667
178Lethargy (HP:0001254)1.71246273
179Focal dystonia (HP:0004373)1.70757150
180* Vomiting (HP:0002013)1.69820433
181Frequent falls (HP:0002359)1.69406191
182Craniofacial dystonia (HP:0012179)1.68868739
183Nuclear cataract (HP:0100018)1.66030318
184Restrictive lung disease (HP:0002091)1.65512506
185Abnormality of calcium-phosphate metabolism (HP:0100530)1.64622188
186Dysmetria (HP:0001310)1.63391920
187Depression (HP:0000716)1.62344106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DAPK23.70199202
2EPHA43.60840211
3MAP2K43.06491202
4RIPK43.02636252
5NTRK32.99451475
6MAP3K92.72266440
7BCKDK2.52170620
8ERN12.37399221
9TXK2.29701486
10MAP3K42.27011928
11KSR22.03134136
12TRIB31.91012329
13MAP3K131.80906286
14SIK21.79703854
15MAP2K71.71425873
16SIK11.69783874
17CAMKK11.69558370
18FRK1.68114258
19TAOK31.63588636
20PKN21.57098640
21NTRK21.54847334
22FGFR41.46517644
23MINK11.43012211
24BLK1.41177131
25PTK2B1.34851327
26PAK61.32900244
27DAPK11.29295965
28MAP4K11.28003668
29PLK21.27806947
30CSK1.27713904
31RIPK11.25126842
32PHKG11.23441779
33PHKG21.23441779
34INSRR1.19898247
35ARAF1.15920617
36ABL21.15727566
37GRK51.14502908
38MAPK121.11674732
39MAPK111.06551053
40JAK21.05585810
41MAP3K141.05504930
42PRKD21.04827055
43RET1.04291335
44PDPK11.03976297
45NTRK11.03955969
46ZAP701.03273981
47MAP3K11.02221804
48SGK31.01733048
49CAMKK21.00074725
50CASK0.99830094
51TBK10.98844287
52UHMK10.97583073
53PRKCG0.96848932
54TYK20.96662873
55TYRO30.96146425
56MAP3K50.95492813
57ADRBK20.94125799
58FES0.92977791
59MAP3K110.92896964
60KSR10.92668217
61PINK10.92152243
62MARK20.88699181
63PRKCZ0.85623263
64SGK20.85276947
65PDK10.84719033
66ITK0.84524462
67BMPR20.83881004
68MAP2K10.83545643
69CDK50.83536513
70TNK20.83429391
71JAK10.82122241
72SGK4940.81150157
73SGK2230.81150157
74CAMK1G0.80731961
75FGFR30.80552241
76TAOK10.80152156
77MARK10.80131709
78MAP3K70.79919056
79FGR0.79479685
80ERBB40.78892275
81MAPK70.77760411
82OBSCN0.77760163
83IKBKE0.76701975
84STK380.73612575
85MST1R0.73579267
86MAP3K60.72974674
87MAP3K120.72944421
88MOS0.72928853
89SGK10.71709844
90MAP3K20.70311218
91CAMK2A0.69353832
92MAPK130.66755094
93GRK70.66278700
94PRKCH0.65130173
95PIK3CG0.64302096
96GRK60.64132806
97BMX0.64101340
98PKN10.63787449
99PRKD10.62727922
100HCK0.62625885
101LCK0.62356172
102DDR20.62248608
103PRKACG0.61654869
104TAOK20.60678454
105TGFBR20.60318709
106JAK30.60162779
107SIK30.59872959
108CAMK40.59837807
109PTK60.59718967
110FYN0.59574449
111CSF1R0.59139723
112DAPK30.59042208
113CAMK2G0.56144178
114CDC42BPA0.55428614
115LYN0.54680216
116IKBKB0.54582302
117PRKAA20.54000403
118MAP2K30.52190503
119FGFR20.51711652
120ROCK10.51552476
121PRKCE0.51311557
122ROCK20.50826331
123PDGFRB0.50192483
124CAMK1D0.50042709
125MAP3K30.49818739
126RPS6KA30.48865220
127IRAK30.48691323
128RPS6KA20.48590419
129ERBB20.48202157
130PRPF4B0.47967029
131PTK20.45778361
132PRKAA10.44748326
133PRKD30.43904352
134STK110.43593040
135PAK30.43112212
136PRKCQ0.42333304
137MAPK40.41807622
138SYK0.41795342
139EGFR0.40009034
140EPHB10.39491115
141CAMK10.38428203
142RAF10.38250601

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.18464793
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.97504181
3Nitrogen metabolism_Homo sapiens_hsa009103.64818699
4Arginine biosynthesis_Homo sapiens_hsa002203.21077733
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84780126
6Complement and coagulation cascades_Homo sapiens_hsa046102.78625840
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52012636
8Staphylococcus aureus infection_Homo sapiens_hsa051502.36435971
9Tryptophan metabolism_Homo sapiens_hsa003802.16828823
10Fatty acid degradation_Homo sapiens_hsa000712.13545082
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.09924448
12Butanoate metabolism_Homo sapiens_hsa006501.86136139
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82779382
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81042856
15Lysosome_Homo sapiens_hsa041421.79401514
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78860970
17PPAR signaling pathway_Homo sapiens_hsa033201.73548410
18Bile secretion_Homo sapiens_hsa049761.72584072
19Peroxisome_Homo sapiens_hsa041461.69598484
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.65518996
21Rheumatoid arthritis_Homo sapiens_hsa053231.61809238
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60297123
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.58875641
24Fatty acid metabolism_Homo sapiens_hsa012121.58274796
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58205708
26Osteoclast differentiation_Homo sapiens_hsa043801.57528472
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.54423491
28Caffeine metabolism_Homo sapiens_hsa002321.53879430
29Other glycan degradation_Homo sapiens_hsa005111.49420479
30Chemical carcinogenesis_Homo sapiens_hsa052041.45883083
31Propanoate metabolism_Homo sapiens_hsa006401.41156252
32Histidine metabolism_Homo sapiens_hsa003401.40295484
33Graft-versus-host disease_Homo sapiens_hsa053321.38761655
34Type I diabetes mellitus_Homo sapiens_hsa049401.36519482
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35427175
36Autoimmune thyroid disease_Homo sapiens_hsa053201.34737205
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33228066
38beta-Alanine metabolism_Homo sapiens_hsa004101.31735949
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30942176
40Phenylalanine metabolism_Homo sapiens_hsa003601.29959269
41Allograft rejection_Homo sapiens_hsa053301.26283774
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23870829
43Phagosome_Homo sapiens_hsa041451.23229822
44Tuberculosis_Homo sapiens_hsa051521.23073019
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22015875
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21747875
47ABC transporters_Homo sapiens_hsa020101.18608872
48Leishmaniasis_Homo sapiens_hsa051401.18369043
49Pyruvate metabolism_Homo sapiens_hsa006201.17736309
50Dorso-ventral axis formation_Homo sapiens_hsa043201.17370247
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16365757
52Starch and sucrose metabolism_Homo sapiens_hsa005001.14692986
53Retinol metabolism_Homo sapiens_hsa008301.12001176
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10911340
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10203514
56B cell receptor signaling pathway_Homo sapiens_hsa046621.08124015
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06461266
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.06357529
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05979188
60Tyrosine metabolism_Homo sapiens_hsa003501.05332816
61Chemokine signaling pathway_Homo sapiens_hsa040621.04105139
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02822227
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01417402
64SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00622078
65T cell receptor signaling pathway_Homo sapiens_hsa046601.00508639
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98185413
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.94382849
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.93774194
69Vibrio cholerae infection_Homo sapiens_hsa051100.92816263
70Cholinergic synapse_Homo sapiens_hsa047250.91685656
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.90559518
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88774029
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86706655
74Carbon metabolism_Homo sapiens_hsa012000.85876410
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.85482797
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85083509
77Biosynthesis of amino acids_Homo sapiens_hsa012300.85047914
78Selenocompound metabolism_Homo sapiens_hsa004500.84739222
79Nicotine addiction_Homo sapiens_hsa050330.82652129
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82047059
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.81572765
82Fatty acid elongation_Homo sapiens_hsa000620.80687652
83Sulfur metabolism_Homo sapiens_hsa009200.79603394
84Synaptic vesicle cycle_Homo sapiens_hsa047210.79445977
85cAMP signaling pathway_Homo sapiens_hsa040240.79388046
86GnRH signaling pathway_Homo sapiens_hsa049120.79278331
87Malaria_Homo sapiens_hsa051440.78696744
88Long-term depression_Homo sapiens_hsa047300.78551705
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.77889388
90Hematopoietic cell lineage_Homo sapiens_hsa046400.76331246
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76248858
92Toxoplasmosis_Homo sapiens_hsa051450.76124456
93VEGF signaling pathway_Homo sapiens_hsa043700.75542375
94Fat digestion and absorption_Homo sapiens_hsa049750.75359393
95Prion diseases_Homo sapiens_hsa050200.75094950
96Asthma_Homo sapiens_hsa053100.74440375
97Estrogen signaling pathway_Homo sapiens_hsa049150.74389829
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74226738
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73001899
100Antigen processing and presentation_Homo sapiens_hsa046120.72655145
101TNF signaling pathway_Homo sapiens_hsa046680.72273124
102Endocytosis_Homo sapiens_hsa041440.72093645
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71434134
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70337296
105Salmonella infection_Homo sapiens_hsa051320.68553460
106MAPK signaling pathway_Homo sapiens_hsa040100.67884069
107Viral myocarditis_Homo sapiens_hsa054160.67518405
108Platelet activation_Homo sapiens_hsa046110.67100960
109GABAergic synapse_Homo sapiens_hsa047270.67046332
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66025035
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64952913
112Serotonergic synapse_Homo sapiens_hsa047260.64704263
113Rap1 signaling pathway_Homo sapiens_hsa040150.63794460
114Primary immunodeficiency_Homo sapiens_hsa053400.63297046
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.62999837
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62948893
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.61919865
118Glioma_Homo sapiens_hsa052140.61597808
119Renal cell carcinoma_Homo sapiens_hsa052110.61044460
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60622009
121Ras signaling pathway_Homo sapiens_hsa040140.59394784
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.58769426
123Circadian rhythm_Homo sapiens_hsa047100.58640864
124Arginine and proline metabolism_Homo sapiens_hsa003300.57745704
125Prolactin signaling pathway_Homo sapiens_hsa049170.57017622
126Sphingolipid metabolism_Homo sapiens_hsa006000.56292550
127Sulfur relay system_Homo sapiens_hsa041220.55985398
128Vitamin B6 metabolism_Homo sapiens_hsa007500.55770138
129Glycerolipid metabolism_Homo sapiens_hsa005610.55427683
130Steroid biosynthesis_Homo sapiens_hsa001000.55172383
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54384164
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53997211
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49725749
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.48508155
135Adipocytokine signaling pathway_Homo sapiens_hsa049200.48503337
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48429912
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47493230
138Lysine degradation_Homo sapiens_hsa003100.47185200
139Glutamatergic synapse_Homo sapiens_hsa047240.46203249
140Folate biosynthesis_Homo sapiens_hsa007900.46164855
141Long-term potentiation_Homo sapiens_hsa047200.46019918
142Type II diabetes mellitus_Homo sapiens_hsa049300.45642266
143Morphine addiction_Homo sapiens_hsa050320.43674738
144Insulin resistance_Homo sapiens_hsa049310.42261866
145Fatty acid biosynthesis_Homo sapiens_hsa000610.42143940
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41944801
147Circadian entrainment_Homo sapiens_hsa047130.41539967
148Collecting duct acid secretion_Homo sapiens_hsa049660.39161740
149Amphetamine addiction_Homo sapiens_hsa050310.38429277
150Glucagon signaling pathway_Homo sapiens_hsa049220.38274197
151Salivary secretion_Homo sapiens_hsa049700.37232493
152Olfactory transduction_Homo sapiens_hsa047400.35283707
153Insulin secretion_Homo sapiens_hsa049110.31897956
154Vitamin digestion and absorption_Homo sapiens_hsa049770.30731759
155Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30048482
156Renin secretion_Homo sapiens_hsa049240.28019143
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26675135
158African trypanosomiasis_Homo sapiens_hsa051430.24313187
159Ovarian steroidogenesis_Homo sapiens_hsa049130.23913784
160Dopaminergic synapse_Homo sapiens_hsa047280.21390963
161Oxytocin signaling pathway_Homo sapiens_hsa049210.20535787
162* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19157338
163Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.18827492
164Calcium signaling pathway_Homo sapiens_hsa040200.18169723
165* Metabolic pathways_Homo sapiens_hsa011000.17516112
166Insulin signaling pathway_Homo sapiens_hsa049100.17395206
167Glycerophospholipid metabolism_Homo sapiens_hsa005640.17296911
168Cyanoamino acid metabolism_Homo sapiens_hsa004600.17073476
169Pertussis_Homo sapiens_hsa051330.14969863
170Gastric acid secretion_Homo sapiens_hsa049710.14600359
171Cocaine addiction_Homo sapiens_hsa050300.14115932

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