ST3GAL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)4.70956480
2lymph vessel development (GO:0001945)4.59533367
3neutrophil activation involved in immune response (GO:0002283)4.43796037
4regulation of skeletal muscle contraction (GO:0014819)4.21820540
5microglial cell activation (GO:0001774)4.17016106
6glomerular visceral epithelial cell development (GO:0072015)4.12958448
7glomerulus development (GO:0032835)4.08192505
8positive regulation of chemokine secretion (GO:0090197)4.05017773
9response to peptidoglycan (GO:0032494)4.02792630
10positive regulation of mast cell activation (GO:0033005)3.93200826
11G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.90622358
12positive regulation of mast cell activation involved in immune response (GO:0033008)3.84469634
13positive regulation of mast cell degranulation (GO:0043306)3.84469634
14detection of molecule of bacterial origin (GO:0032490)3.82756045
15surfactant homeostasis (GO:0043129)3.76208625
16regulation of interferon-beta biosynthetic process (GO:0045357)3.68329998
17regulation of chemokine secretion (GO:0090196)3.64398009
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62938276
19glomerular epithelial cell development (GO:0072310)3.62072225
20skeletal muscle adaptation (GO:0043501)3.53622695
21regulation of germinal center formation (GO:0002634)3.51738596
22oligosaccharide catabolic process (GO:0009313)3.44364822
23vascular endothelial growth factor signaling pathway (GO:0038084)3.42890390
24tyrosine metabolic process (GO:0006570)3.42455945
25positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.37046668
26monocyte differentiation (GO:0030224)3.29364720
27regulation of mast cell activation (GO:0033003)3.28500008
28histamine secretion (GO:0001821)3.26423333
29positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.24458392
30negative regulation of interleukin-12 production (GO:0032695)3.24344687
31pigment cell differentiation (GO:0050931)3.17802764
32establishment of endothelial barrier (GO:0061028)3.11265307
33actin-myosin filament sliding (GO:0033275)3.08838849
34muscle filament sliding (GO:0030049)3.08838849
35sarcoplasmic reticulum calcium ion transport (GO:0070296)3.08466088
36negative regulation of bone resorption (GO:0045779)3.06731078
37tryptophan catabolic process (GO:0006569)3.05670690
38indole-containing compound catabolic process (GO:0042436)3.05670690
39indolalkylamine catabolic process (GO:0046218)3.05670690
40positive regulation of vasculogenesis (GO:2001214)3.00048725
41melanin metabolic process (GO:0006582)2.99487034
42macrophage activation (GO:0042116)2.97784737
43glomerular basement membrane development (GO:0032836)2.97710361
44regulation of mast cell degranulation (GO:0043304)2.97568370
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97028863
46actin-mediated cell contraction (GO:0070252)2.95780073
47regulation of T cell tolerance induction (GO:0002664)2.95529553
48positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94349675
49regulation of mast cell activation involved in immune response (GO:0033006)2.94144207
50melanin biosynthetic process (GO:0042438)2.93161541
51melanocyte differentiation (GO:0030318)2.92590595
52skeletal muscle contraction (GO:0003009)2.91402144
53sodium-independent organic anion transport (GO:0043252)2.89745518
54keratan sulfate catabolic process (GO:0042340)2.87856178
55regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.87731387
56detection of external biotic stimulus (GO:0098581)2.87629183
57cellular response to ethanol (GO:0071361)2.87451282
58myeloid cell activation involved in immune response (GO:0002275)2.86849415
59purinergic nucleotide receptor signaling pathway (GO:0035590)2.86437166
60neutrophil activation (GO:0042119)2.86224985
61definitive hemopoiesis (GO:0060216)2.86089742
62granulocyte activation (GO:0036230)2.86075648
63cellular extravasation (GO:0045123)2.85901166
64cGMP-mediated signaling (GO:0019934)2.85570142
65positive regulation of smooth muscle cell migration (GO:0014911)2.82073351
66positive regulation of leukocyte degranulation (GO:0043302)2.80813792
67regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.79233391
68aromatic amino acid family catabolic process (GO:0009074)2.77777331
69immunoglobulin mediated immune response (GO:0016064)2.76597446
70positive regulation of respiratory burst (GO:0060267)2.76191127
71chemical homeostasis within a tissue (GO:0048875)2.74645412
72cellular biogenic amine catabolic process (GO:0042402)2.74170001
73amine catabolic process (GO:0009310)2.74170001
74hepatocyte apoptotic process (GO:0097284)2.73196077
75macrophage activation involved in immune response (GO:0002281)2.73097188
76platelet dense granule organization (GO:0060155)2.70141723
77secondary metabolite biosynthetic process (GO:0044550)2.69878868
78germinal center formation (GO:0002467)2.69556859
79phospholipid homeostasis (GO:0055091)2.68307294
80iron ion import (GO:0097286)2.67245320
81T-helper 1 type immune response (GO:0042088)2.65313489
82regulation of B cell receptor signaling pathway (GO:0050855)2.65215310
83regulation of vasculogenesis (GO:2001212)2.64812352
84tryptophan metabolic process (GO:0006568)2.63118355
85regulation of hypersensitivity (GO:0002883)2.62913066
86histamine transport (GO:0051608)2.61825515
87negative regulation of platelet activation (GO:0010544)2.59147273
88negative regulation of systemic arterial blood pressure (GO:0003085)2.58929901
89monocyte chemotaxis (GO:0002548)2.58701864
90sprouting angiogenesis (GO:0002040)2.58124378
91positive regulation of interferon-alpha production (GO:0032727)2.57867509
92striated muscle atrophy (GO:0014891)2.56008699
93N-acetylneuraminate metabolic process (GO:0006054)2.55389017
94positive regulation of gamma-delta T cell activation (GO:0046645)2.55079165
95aromatic amino acid family metabolic process (GO:0009072)2.54180419
96cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.53556547
97regulation of myeloid leukocyte mediated immunity (GO:0002886)2.53215592
98negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.51252381
99detection of biotic stimulus (GO:0009595)2.50520430
100lipopolysaccharide-mediated signaling pathway (GO:0031663)2.49733168
101cellular response to thyroid hormone stimulus (GO:0097067)2.49355759
102intracellular pH reduction (GO:0051452)2.47654477
103triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.46749426
104detection of other organism (GO:0098543)2.46469114
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.46397301
106L-phenylalanine catabolic process (GO:0006559)2.46397301
107positive regulation by symbiont of host defense response (GO:0052509)2.46367594
108modulation by symbiont of host defense response (GO:0052031)2.46367594
109modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46367594
110modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46367594
111positive regulation by organism of defense response of other organism involved in symbiotic interact2.46367594
112modulation by symbiont of host immune response (GO:0052553)2.46367594
113positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.46022978
114positive regulation of toll-like receptor signaling pathway (GO:0034123)2.44877779
115response to muscle activity (GO:0014850)2.44318015
116regulation of interferon-alpha production (GO:0032647)2.44306924
117pathway-restricted SMAD protein phosphorylation (GO:0060389)2.44171555
118interferon-gamma-mediated signaling pathway (GO:0060333)2.44118564
119actin filament-based movement (GO:0030048)2.43520428
120peptidyl-tyrosine autophosphorylation (GO:0038083)2.43389797
121phagosome maturation (GO:0090382)2.43311832
122regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.43097916
123xenobiotic catabolic process (GO:0042178)2.42347761
124response to host immune response (GO:0052572)2.41354512
125response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41354512
126epithelial cell differentiation involved in kidney development (GO:0035850)2.40182554
127complement activation, alternative pathway (GO:0006957)2.39751859
128regulation of endothelial cell differentiation (GO:0045601)2.39524679
129neutrophil chemotaxis (GO:0030593)2.39434248
130regulation of cell communication by electrical coupling (GO:0010649)2.38868672
131regulation of interleukin-6 biosynthetic process (GO:0045408)2.37439630
132low-density lipoprotein particle remodeling (GO:0034374)2.37415212
133import into cell (GO:0098657)2.36880201
134regulation of relaxation of muscle (GO:1901077)2.36227250
135muscle atrophy (GO:0014889)2.35819783
136positive regulation of cellular amide metabolic process (GO:0034250)2.35748802
137leukocyte tethering or rolling (GO:0050901)2.35223045
138kynurenine metabolic process (GO:0070189)2.35129149
139negative regulation of granulocyte differentiation (GO:0030853)2.34665897
140lysosome organization (GO:0007040)2.34343902
141lytic vacuole organization (GO:0080171)2.34343902
142neutrophil migration (GO:1990266)2.33760168
143mesodermal cell differentiation (GO:0048333)2.33556370
144response to methylmercury (GO:0051597)2.32980401
145regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32769074
146germ cell migration (GO:0008354)2.32324728
147neutrophil mediated immunity (GO:0002446)2.31963158
148regulation of mononuclear cell migration (GO:0071675)2.31256127
149regulation of platelet activation (GO:0010543)2.31052473
150negative regulation of interleukin-1 beta production (GO:0032691)2.30645209
151defense response to protozoan (GO:0042832)2.30458873
152glycolipid catabolic process (GO:0019377)2.30436682
153positive regulation of focal adhesion assembly (GO:0051894)2.30173209
154positive regulation of cell junction assembly (GO:1901890)2.30173209
155transcytosis (GO:0045056)2.29637835
156natural killer cell differentiation (GO:0001779)2.29598731
157hydrogen peroxide biosynthetic process (GO:0050665)2.28723870
158vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.28673103
159negative regulation of bone remodeling (GO:0046851)2.27803004
160lymphangiogenesis (GO:0001946)2.27694554
161negative regulation of interleukin-17 production (GO:0032700)2.27436218
162negative regulation of mast cell activation (GO:0033004)2.27121888
163superoxide anion generation (GO:0042554)2.26930783
164patterning of blood vessels (GO:0001569)2.26774771
165glycosphingolipid catabolic process (GO:0046479)2.26712161
166negative regulation of tissue remodeling (GO:0034104)2.26640971
167regulation of leukocyte degranulation (GO:0043300)2.26223812
168reverse cholesterol transport (GO:0043691)2.26131646
169Notch receptor processing (GO:0007220)2.26011270
170negative regulation of protein autophosphorylation (GO:0031953)2.24798160
171regulation of platelet aggregation (GO:0090330)2.22556490
172negative regulation of muscle contraction (GO:0045932)2.20948709
173negative regulation of Rho protein signal transduction (GO:0035024)2.20347534
174response to laminar fluid shear stress (GO:0034616)2.19365208
175positive regulation of antigen processing and presentation (GO:0002579)2.19321676
176regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.18349472
177blood vessel maturation (GO:0001955)2.17090024
178response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.16890047
179negative regulation of cAMP-mediated signaling (GO:0043951)2.16276743
180relaxation of cardiac muscle (GO:0055119)2.15753247
181substrate-dependent cell migration (GO:0006929)2.15464482
182dendritic cell migration (GO:0036336)2.14984438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.18226923
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.05763158
3GATA1_22025678_ChIP-Seq_K562_Human3.16347292
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.04783223
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.81622699
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.79709509
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.41813364
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.41239870
9RUNX_20019798_ChIP-Seq_JUKART_Human2.34400539
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.33138291
11* IRF8_27001747_Chip-Seq_BMDM_Mouse2.27095876
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.20346330
13SCL_19346495_ChIP-Seq_HPC-7_Human2.17740820
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15903839
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10734767
16* GATA2_21666600_ChIP-Seq_HMVEC_Human2.04173060
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.03939520
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00673747
19ESR1_20079471_ChIP-ChIP_T-47D_Human2.00430183
20FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.99603011
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93904359
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.92250926
23* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.90620371
24GBX2_23144817_ChIP-Seq_PC3_Human1.90437050
25CDX2_20551321_ChIP-Seq_CACO-2_Human1.84858189
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83950969
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83075498
28VDR_24787735_ChIP-Seq_THP-1_Human1.78517683
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69576878
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69103212
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.67758515
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67662114
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.67401323
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.66953014
35SOX2_20726797_ChIP-Seq_SW620_Human1.66480356
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64666305
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64241210
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58539696
39* CJUN_26792858_Chip-Seq_BT549_Human1.58479146
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.57268411
41TAF15_26573619_Chip-Seq_HEK293_Human1.56736583
42AR_21572438_ChIP-Seq_LNCaP_Human1.56690158
43* P300_19829295_ChIP-Seq_ESCs_Human1.51115713
44GATA1_19941826_ChIP-Seq_K562_Human1.49282050
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48303030
46ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45317489
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41572781
48SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41387671
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.41094218
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41061179
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40513842
52VDR_22108803_ChIP-Seq_LS180_Human1.39999898
53ER_23166858_ChIP-Seq_MCF-7_Human1.39969667
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.39619610
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39169526
56SPI1_23547873_ChIP-Seq_NB4_Human1.38098870
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.37960063
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37643916
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.37288877
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36225814
61GATA2_19941826_ChIP-Seq_K562_Human1.34724800
62GATA3_26560356_Chip-Seq_TH2_Human1.33733184
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30712962
64LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.30251121
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.28205631
66* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27856027
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26932774
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26186561
69* SOX2_19829295_ChIP-Seq_ESCs_Human1.24169533
70* NANOG_19829295_ChIP-Seq_ESCs_Human1.24169533
71SMAD4_21799915_ChIP-Seq_A2780_Human1.22923553
72CLOCK_20551151_ChIP-Seq_293T_Human1.22497670
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.22356055
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.22044419
75EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21500895
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20921491
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19713655
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.19087848
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18884887
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17745787
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17687991
82IGF1R_20145208_ChIP-Seq_DFB_Human1.16644678
83* AR_25329375_ChIP-Seq_VCAP_Human1.15864538
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15864042
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15780735
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15211531
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.14701493
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14504428
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14241062
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12806431
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11519655
92PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10805838
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.10659725
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09561560
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09495586
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09448440
97SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09448440
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09368621
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09368621
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.08819361
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08441273
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08157024
103TP53_18474530_ChIP-ChIP_U2OS_Human1.07707384
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.07463534
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.07121342
106MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06024158
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05799550
108ZNF274_21170338_ChIP-Seq_K562_Hela1.05486810
109SMRT_27268052_Chip-Seq_Bcells_Human1.05433429
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05405975
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05272295
112STAT3_23295773_ChIP-Seq_U87_Human1.04900154
113FUS_26573619_Chip-Seq_HEK293_Human1.04705089
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.04664973
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03835859
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03438495
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03136230
118CDX2_22108803_ChIP-Seq_LS180_Human1.03014678
119PRDM14_20953172_ChIP-Seq_ESCs_Human1.02995062
120P53_22387025_ChIP-Seq_ESCs_Mouse1.01968211
121TBX20_22328084_ChIP-Seq_HEART_Mouse1.01868574
122TBX20_22080862_ChIP-Seq_HEART_Mouse1.01868574
123* TCF4_23295773_ChIP-Seq_U87_Human1.01524992
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.01445933
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01230624
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00722955
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00671323
128P300_18555785_Chip-Seq_ESCs_Mouse1.00453264
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00271031
130GATA3_27048872_Chip-Seq_THYMUS_Human1.00154123
131BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00074729
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99742810
133FLI1_21867929_ChIP-Seq_TH2_Mouse0.99675712
134FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99113623
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99026391
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99026391
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.98472625
138CBP_20019798_ChIP-Seq_JUKART_Human0.98131482
139KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96561909
140MYB_26560356_Chip-Seq_TH2_Human0.95022258
141SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94757402
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94558727
143BCAT_22108803_ChIP-Seq_LS180_Human0.94212314
144CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90853476
145MAF_26560356_Chip-Seq_TH1_Human0.90474808
146PU_27001747_Chip-Seq_BMDM_Mouse0.90342830
147SPI1_23127762_ChIP-Seq_K562_Human0.89900607
148PIAS1_25552417_ChIP-Seq_VCAP_Human0.88380187
149RXR_22108803_ChIP-Seq_LS180_Human0.87295842
150BRD4_27068464_Chip-Seq_AML-cells_Mouse0.83978067
151VDR_24763502_ChIP-Seq_THP-1_Human0.83810687
152* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.83436058
153EGR1_19032775_ChIP-ChIP_M12_Human0.80969249
154LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80693417
155ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80601487
156STAT6_21828071_ChIP-Seq_BEAS2B_Human0.79881677
157* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79310590
158GATA4_25053715_ChIP-Seq_YYC3_Human0.78350171
159* GATA1_19941827_ChIP-Seq_MEL_Mouse0.77810388
160MYB_26560356_Chip-Seq_TH1_Human0.77242868
161AHR_22903824_ChIP-Seq_MCF-7_Human0.76248844
162GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76226092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.41621616
2MP0003195_calcinosis3.66971168
3MP0003724_increased_susceptibility_to3.63976176
4MP0001879_abnormal_lymphatic_vessel3.11541422
5MP0000372_irregular_coat_pigmentation3.06874584
6MP0002139_abnormal_hepatobiliary_system3.04033245
7MP0005167_abnormal_blood-brain_barrier3.01316471
8MP0000569_abnormal_digit_pigmentation2.80043268
9MP0010368_abnormal_lymphatic_system2.78502593
10MP0005075_abnormal_melanosome_morpholog2.72632206
11MP0002837_dystrophic_cardiac_calcinosis2.60074586
12MP0005058_abnormal_lysosome_morphology2.59609136
13MP0003172_abnormal_lysosome_physiology2.58035608
14MP0006082_CNS_inflammation2.47826294
15MP0000749_muscle_degeneration2.36417972
16MP0000015_abnormal_ear_pigmentation2.29828336
17MP0003806_abnormal_nucleotide_metabolis2.29080969
18MP0004484_altered_response_of2.26660100
19MP0005671_abnormal_response_to2.25014991
20MP0003828_pulmonary_edema2.23614111
21MP0005171_absent_coat_pigmentation2.23289048
22MP0001873_stomach_inflammation2.22257404
23MP0003136_yellow_coat_color2.19285317
24MP0000371_diluted_coat_color2.14582580
25MP0005174_abnormal_tail_pigmentation2.09619875
26MP0004510_myositis1.98303290
27MP0003191_abnormal_cellular_cholesterol1.98211288
28MP0004145_abnormal_muscle_electrophysio1.94910410
29MP0000343_altered_response_to1.88272580
30MP0001835_abnormal_antigen_presentation1.87249615
31MP0009840_abnormal_foam_cell1.85169079
32MP0008004_abnormal_stomach_pH1.79841328
33MP0004036_abnormal_muscle_relaxation1.77635954
34MP0009278_abnormal_bone_marrow1.69355732
35MP0001851_eye_inflammation1.66171283
36MP0002095_abnormal_skin_pigmentation1.61537291
37MP0004084_abnormal_cardiac_muscle1.58864021
38MP0003646_muscle_fatigue1.58428322
39MP0002452_abnormal_antigen_presenting1.56859720
40MP0005408_hypopigmentation1.55154638
41MP0001533_abnormal_skeleton_physiology1.53632393
42MP0002419_abnormal_innate_immunity1.53338104
43MP0001800_abnormal_humoral_immune1.51991801
44MP0005165_increased_susceptibility_to1.51912458
45MP0001790_abnormal_immune_system1.48395992
46MP0005387_immune_system_phenotype1.48395992
47MP0002148_abnormal_hypersensitivity_rea1.45306840
48MP0002405_respiratory_system_inflammati1.42193111
49MP0003045_fibrosis1.40895125
50MP0004272_abnormal_basement_membrane1.37907217
51MP0005464_abnormal_platelet_physiology1.34695971
52MP0002723_abnormal_immune_serum1.33032066
53MP0005084_abnormal_gallbladder_morpholo1.32515024
54MP0002933_joint_inflammation1.32179559
55MP0005166_decreased_susceptibility_to1.31084218
56MP0003300_gastrointestinal_ulcer1.30689298
57MP0003656_abnormal_erythrocyte_physiolo1.30560857
58MP0005000_abnormal_immune_tolerance1.29858695
59MP0001819_abnormal_immune_cell1.29373463
60MP0002420_abnormal_adaptive_immunity1.28952050
61MP0009785_altered_susceptibility_to1.28336443
62MP0005620_abnormal_muscle_contractility1.27382658
63MP0005365_abnormal_bile_salt1.27353563
64MP0000767_abnormal_smooth_muscle1.26025240
65MP0000249_abnormal_blood_vessel1.23777618
66MP0000604_amyloidosis1.23452416
67MP0003303_peritoneal_inflammation1.22681593
68MP0005397_hematopoietic_system_phenotyp1.22652959
69MP0001545_abnormal_hematopoietic_system1.22652959
70MP0006054_spinal_hemorrhage1.22554813
71MP0002090_abnormal_vision1.22160257
72MP0000733_abnormal_muscle_development1.21851081
73MP0008875_abnormal_xenobiotic_pharmacok1.21850800
74MP0003878_abnormal_ear_physiology1.20137802
75MP0005377_hearing/vestibular/ear_phenot1.20137802
76MP0005025_abnormal_response_to1.19992275
77MP0001324_abnormal_eye_pigmentation1.19391404
78MP0002998_abnormal_bone_remodeling1.18442558
79MP0002332_abnormal_exercise_endurance1.16287937
80MP0000465_gastrointestinal_hemorrhage1.15645497
81MP0010155_abnormal_intestine_physiology1.15113080
82MP0003279_aneurysm1.14451928
83MP0002075_abnormal_coat/hair_pigmentati1.11130065
84MP0003950_abnormal_plasma_membrane1.10346210
85MP0006138_congestive_heart_failure1.09786811
86MP0004130_abnormal_muscle_cell1.09180032
87MP0004215_abnormal_myocardial_fiber1.09163996
88MP0002396_abnormal_hematopoietic_system1.09057808
89MP0003075_altered_response_to1.09027255
90MP0000685_abnormal_immune_system1.08580339
91MP0002972_abnormal_cardiac_muscle1.07730160
92MP0004883_abnormal_blood_vessel1.05480111
93MP0003943_abnormal_hepatobiliary_system1.04787586
94MP0003436_decreased_susceptibility_to1.04615302
95MP0003763_abnormal_thymus_physiology1.04123352
96MP0009379_abnormal_foot_pigmentation1.04030061
97MP0003453_abnormal_keratinocyte_physiol1.02386905
98MP0002106_abnormal_muscle_physiology1.01593486
99MP0001542_abnormal_bone_strength0.98893216
100MP0002166_altered_tumor_susceptibility0.98868182
101MP0002638_abnormal_pupillary_reflex0.98364624
102MP0004381_abnormal_hair_follicle0.98361033
103MP0005623_abnormal_meninges_morphology0.96705765
104MP0005369_muscle_phenotype0.96201537
105MP0009046_muscle_twitch0.95966029
106MP0002877_abnormal_melanocyte_morpholog0.95749719
107MP0004185_abnormal_adipocyte_glucose0.95748878
108MP0001845_abnormal_inflammatory_respons0.95488748
109MP0009764_decreased_sensitivity_to0.94579429
110MP0000920_abnormal_myelination0.94537796
111MP0009333_abnormal_splenocyte_physiolog0.93179555
112MP0003690_abnormal_glial_cell0.93128356
113MP0005164_abnormal_response_to0.92982671
114MP0001958_emphysema0.92809741
115MP0006036_abnormal_mitochondrial_physio0.92758281
116MP0000747_muscle_weakness0.91341721
117MP0008469_abnormal_protein_level0.90272439
118MP0002136_abnormal_kidney_physiology0.88486170
119MP0003633_abnormal_nervous_system0.87356301
120MP0001186_pigmentation_phenotype0.87353148
121MP0009384_cardiac_valve_regurgitation0.86712322
122MP0002108_abnormal_muscle_morphology0.86572168
123MP0002138_abnormal_hepatobiliary_system0.86272240
124MP0004947_skin_inflammation0.85891740
125MP0003252_abnormal_bile_duct0.85584232
126MP0005379_endocrine/exocrine_gland_phen0.85351193
127MP0002128_abnormal_blood_circulation0.84045683
128MP0004808_abnormal_hematopoietic_stem0.84027472
129MP0000689_abnormal_spleen_morphology0.83694186
130MP0002009_preneoplasia0.82573223
131MP0005085_abnormal_gallbladder_physiolo0.82301123
132MP0000716_abnormal_immune_system0.82162193
133MP0005310_abnormal_salivary_gland0.81692087
134MP0004782_abnormal_surfactant_physiolog0.81219134
135MP0010329_abnormal_lipoprotein_level0.79760442
136MP0002693_abnormal_pancreas_physiology0.76647181
137MP0004043_abnormal_pH_regulation0.75130388
138MP0005253_abnormal_eye_physiology0.72587530
139MP0009763_increased_sensitivity_to0.70995158
140MP0002118_abnormal_lipid_homeostasis0.69840136
141MP0005551_abnormal_eye_electrophysiolog0.67401394
142MP0002909_abnormal_adrenal_gland0.67166695
143MP0002229_neurodegeneration0.66900693
144MP0005535_abnormal_body_temperature0.66214467
145MP0005670_abnormal_white_adipose0.65218989
146MP0005332_abnormal_amino_acid0.64888491
147MP0005451_abnormal_body_composition0.63981610
148MP0001853_heart_inflammation0.62384923

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.74064463
2Abnormality of liposaccharide metabolism (HP:0010968)5.74064463
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.74064463
4Exercise-induced muscle cramps (HP:0003710)4.98161881
5Systemic lupus erythematosus (HP:0002725)4.95338033
6Muscle fiber inclusion bodies (HP:0100299)4.44807226
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.26691426
8Glomerulonephritis (HP:0000099)4.23047235
9Exercise-induced myalgia (HP:0003738)4.15558118
10Nemaline bodies (HP:0003798)4.10699540
11Ileus (HP:0002595)3.73972934
12Increased cerebral lipofuscin (HP:0011813)3.64192784
13Muscle hypertrophy of the lower extremities (HP:0008968)3.59364871
14Arterial tortuosity (HP:0005116)3.54033279
15Congenital, generalized hypertrichosis (HP:0004540)3.49504412
16Muscle stiffness (HP:0003552)3.48119749
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.37445929
18Recurrent gram-negative bacterial infections (HP:0005420)3.36885804
19Hypoplasia of the fovea (HP:0007750)3.32037094
20Aplasia/Hypoplasia of the fovea (HP:0008060)3.32037094
21Albinism (HP:0001022)3.22304797
22Hematochezia (HP:0002573)3.21192471
23Colitis (HP:0002583)3.14074960
24Aortic aneurysm (HP:0004942)3.10441282
25Abnormality of macrophages (HP:0004311)3.09435251
26Vascular tortuosity (HP:0004948)3.08116077
27Calf muscle hypertrophy (HP:0008981)3.03141805
28Urethral obstruction (HP:0000796)3.01925130
29Spontaneous hematomas (HP:0007420)3.01663012
30Stomatitis (HP:0010280)3.01285843
31Disinhibition (HP:0000734)3.00079622
32Round ear (HP:0100830)2.91482548
33Blue irides (HP:0000635)2.89135257
34Thick nail (HP:0001805)2.89037818
35Paralysis (HP:0003470)2.88989107
36White forelock (HP:0002211)2.84646487
37Ulnar deviation of the wrist (HP:0003049)2.84360552
38Recurrent abscess formation (HP:0002722)2.82565859
39Aplasia/Hypoplasia of the macula (HP:0008059)2.79440332
40Abnormality of the fovea (HP:0000493)2.78128378
41Polycythemia (HP:0001901)2.74225846
42Distal arthrogryposis (HP:0005684)2.73421275
43Autoimmune thrombocytopenia (HP:0001973)2.73420952
44Patchy hypopigmentation of hair (HP:0011365)2.73325094
45Complement deficiency (HP:0004431)2.71854786
46Retrobulbar optic neuritis (HP:0100654)2.71070348
47Optic neuritis (HP:0100653)2.71070348
48Nephritis (HP:0000123)2.68407739
49Mesangial abnormality (HP:0001966)2.68284243
50Distal lower limb muscle weakness (HP:0009053)2.66490553
51Generalized hypopigmentation (HP:0007513)2.66275827
52Type 1 muscle fiber predominance (HP:0003803)2.59419701
53Eczematoid dermatitis (HP:0000976)2.58538502
54Inflammation of the large intestine (HP:0002037)2.54354626
55Aplasia/Hypoplasia affecting the retina (HP:0008061)2.54185443
56Loss of speech (HP:0002371)2.54005965
57Agammaglobulinemia (HP:0004432)2.53244083
58Myositis (HP:0100614)2.51728182
59Muscle fiber splitting (HP:0003555)2.49078741
60Ocular albinism (HP:0001107)2.47927704
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46469824
62Abnormality of polysaccharide metabolism (HP:0011012)2.46469824
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46469824
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.46196514
65Nonprogressive disorder (HP:0003680)2.45225530
66Recurrent skin infections (HP:0001581)2.41703220
67Orchitis (HP:0100796)2.41030375
68Chronic diarrhea (HP:0002028)2.40816377
69Myoglobinuria (HP:0002913)2.39916039
70Mediastinal lymphadenopathy (HP:0100721)2.39856915
71Myopathic facies (HP:0002058)2.38913402
72Purpura (HP:0000979)2.38541547
73Reduced subcutaneous adipose tissue (HP:0003758)2.37810907
74Mutism (HP:0002300)2.37767015
75Neonatal short-limb short stature (HP:0008921)2.37416045
76Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34446505
77Hemoptysis (HP:0002105)2.29079037
78EMG: myopathic abnormalities (HP:0003458)2.28966781
79Myocardial infarction (HP:0001658)2.28632765
80Facial diplegia (HP:0001349)2.28394441
81Gastrointestinal inflammation (HP:0004386)2.26795999
82Hyperlipoproteinemia (HP:0010980)2.24460926
83Urinary glycosaminoglycan excretion (HP:0003541)2.23855462
84Mucopolysacchariduria (HP:0008155)2.23855462
85Petechiae (HP:0000967)2.19503608
86Myotonia (HP:0002486)2.18823369
87Chronic obstructive pulmonary disease (HP:0006510)2.17692377
88Obstructive lung disease (HP:0006536)2.17692377
89Hyperkalemia (HP:0002153)2.16720248
90Increased CSF protein (HP:0002922)2.16445874
91Gingival bleeding (HP:0000225)2.15019171
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.14895967
93Autoimmune hemolytic anemia (HP:0001890)2.14676168
94Aortic dissection (HP:0002647)2.12549839
95Iris hypopigmentation (HP:0007730)2.11855344
96IgM deficiency (HP:0002850)2.11398691
97Xanthomatosis (HP:0000991)2.11310420
98Pancreatic islet-cell hyperplasia (HP:0004510)2.10795993
99Long clavicles (HP:0000890)2.10059052
100Epistaxis (HP:0000421)2.09505698
101Hyporeflexia of lower limbs (HP:0002600)2.09403406
102Polyneuropathy (HP:0001271)2.09016928
103Focal segmental glomerulosclerosis (HP:0000097)2.08406331
104Metaphyseal dysplasia (HP:0100255)2.07620708
105Absent phalangeal crease (HP:0006109)2.07607398
106Abnormality of complement system (HP:0005339)2.06940450
107Pulmonary embolism (HP:0002204)2.05377772
108Difficulty running (HP:0009046)2.04029322
109Ketoacidosis (HP:0001993)2.03113622
110Retinal atrophy (HP:0001105)2.01864315
111Hypoplastic ischia (HP:0003175)2.00198162
112Hypoglycemic coma (HP:0001325)1.99233267
113Asymmetric septal hypertrophy (HP:0001670)1.97406815
114Abnormality of iron homeostasis (HP:0011031)1.97329951
115Epiphyseal dysplasia (HP:0002656)1.96704844
116Impaired platelet aggregation (HP:0003540)1.96473867
117Abnormal platelet function (HP:0011869)1.96473867
118Vacuolated lymphocytes (HP:0001922)1.96205792
119Rhabdomyolysis (HP:0003201)1.94884341
120Pulmonary infiltrates (HP:0002113)1.92987446
121Meningitis (HP:0001287)1.92641358
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90877838
123Gangrene (HP:0100758)1.90835440
124Hypoglycemic seizures (HP:0002173)1.90701957
125Abnormality of the prostate (HP:0008775)1.90348803
126Abnormality of the calf musculature (HP:0001430)1.90332018
127Inappropriate behavior (HP:0000719)1.89556766
128Vasculitis (HP:0002633)1.89207192
129Amyloidosis (HP:0011034)1.88725171
130Flat capital femoral epiphysis (HP:0003370)1.88713058
131Increased connective tissue (HP:0009025)1.88319133
132Recurrent bacterial skin infections (HP:0005406)1.84537417
133Cerebral palsy (HP:0100021)1.83652823
134Arterial thrombosis (HP:0004420)1.83128065
135Metaphyseal irregularity (HP:0003025)1.82331774
136Abnormality of transition element cation homeostasis (HP:0011030)1.82049456
137Recurrent fungal infections (HP:0002841)1.81525274
138Cerebral aneurysm (HP:0004944)1.81048235
139Generalized hypopigmentation of hair (HP:0011358)1.81044678
140Prolonged bleeding time (HP:0003010)1.80447199
141Ventricular fibrillation (HP:0001663)1.79622052
142Conjunctival telangiectasia (HP:0000524)1.78979573
143Chronic mucocutaneous candidiasis (HP:0002728)1.78796852
144Recurrent cutaneous fungal infections (HP:0011370)1.78796852
145Neck muscle weakness (HP:0000467)1.78621125
146Bundle branch block (HP:0011710)1.78431906
147Abnormality of chloride homeostasis (HP:0011422)1.78164769
148Pustule (HP:0200039)1.78079787
149Ketosis (HP:0001946)1.77308426
150Abnormality of the periventricular white matter (HP:0002518)1.76461187
151Congenital sensorineural hearing impairment (HP:0008527)1.74741509
152Abnormality of the ischium (HP:0003174)1.74677543
153Thyroiditis (HP:0100646)1.74125658
154Nuclear cataract (HP:0100018)1.73886855
155Tetany (HP:0001281)1.73410103
156Hyperactive renin-angiotensin system (HP:0000841)1.73150890
157IgA deficiency (HP:0002720)1.72474078
158Keratoconjunctivitis (HP:0001096)1.72353222
159Bulbar palsy (HP:0001283)1.71986900
160Increased serum ferritin (HP:0003281)1.71849235
161Osteomyelitis (HP:0002754)1.70174424
162Elevated erythrocyte sedimentation rate (HP:0003565)1.69919456
163Growth hormone excess (HP:0000845)1.69336451
164Abnormal rod and cone electroretinograms (HP:0008323)1.69296383
165Progressive neurologic deterioration (HP:0002344)1.67638118
166Basal ganglia calcification (HP:0002135)1.67636880
167Cerebral hemorrhage (HP:0001342)1.67383822
168Partial duplication of thumb phalanx (HP:0009944)1.67304862
169Keratoconjunctivitis sicca (HP:0001097)1.67296241
170Dysostosis multiplex (HP:0000943)1.65901450
171Abnormality of the basal ganglia (HP:0002134)1.65757468
172Joint hemorrhage (HP:0005261)1.65729311
173Abnormality of the nasal mucosa (HP:0000433)1.65441584
174Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.65403012
175Abnormal tarsal ossification (HP:0008369)1.64238700
176Joint swelling (HP:0001386)1.63756692
177Abnormality of the left ventricular outflow tract (HP:0011103)1.62533841
178Subaortic stenosis (HP:0001682)1.62533841
179Scapular winging (HP:0003691)1.61586617
180Esophageal varix (HP:0002040)1.61168715
181Ridged nail (HP:0001807)1.60597056
182Calcaneovalgus deformity (HP:0001848)1.59945107
183Hyperinsulinemic hypoglycemia (HP:0000825)1.59932584
184Acanthosis nigricans (HP:0000956)1.59300617
185Eosinophilia (HP:0001880)1.58207783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.81937266
2TIE14.95145199
3MAPK153.55573846
4GRK73.12396862
5INSRR3.02598597
6ACVR1B2.60862958
7MAP4K22.40651559
8TAOK32.30163567
9STK102.23273517
10EIF2AK32.01799686
11OBSCN2.00517031
12MST41.95002564
13RIPK41.91504510
14KDR1.87811830
15WNK31.79606319
16TYK21.76823237
17TRPM71.73762663
18MAPK121.69165884
19GRK11.64422542
20NME11.60453852
21MST1R1.60109789
22KIT1.58560977
23PDK21.56999929
24SYK1.55241005
25TEC1.52530267
26IRAK41.51810654
27FGR1.48017842
28ITK1.43762059
29TXK1.42081526
30MAP3K31.41881308
31IRAK31.41427900
32NEK91.39868216
33PHKG11.37116320
34PHKG21.37116320
35MATK1.33165777
36CAMK1D1.32501611
37DAPK21.32270494
38EPHB11.31046598
39PRKG21.28971007
40NLK1.27998814
41PIK3CG1.27076611
42CSK1.20089400
43TBK11.16619918
44PRKAA21.15118487
45MAP2K31.14988089
46IKBKE1.12903232
47TTN1.12556737
48PIK3CA1.12168332
49STK391.11703075
50ZAP701.11194110
51MAP2K61.11107311
52JAK11.07732941
53MAP2K21.07398805
54TNIK1.05318527
55WNK41.04885455
56DMPK1.03129366
57ERBB31.02415800
58MARK31.01348468
59CDK81.01282055
60MAP4K11.00669860
61TGFBR10.99866834
62CAMKK20.99351180
63FLT30.99020599
64CAMK1G0.97172464
65TNK20.96028120
66VRK10.93354281
67CDK90.93097980
68CDK30.92722191
69PAK40.92151640
70MAP3K120.87745195
71MAPK70.87239712
72FGFR30.86987016
73MAP3K50.83221389
74STK38L0.81147038
75PAK30.80724532
76CSF1R0.77571583
77IKBKB0.76706307
78MAPKAPK50.75452446
79IRAK20.74250757
80TSSK60.72761583
81ADRBK20.72346313
82CSNK1G20.71045441
83MYLK0.70085763
84LCK0.69157393
85STK30.68993447
86JAK30.68264118
87MOS0.68259355
88PDK10.67546012
89STK240.66534572
90MUSK0.66004934
91PINK10.64529116
92PLK20.63775666
93IGF1R0.63762933
94MAP3K140.62365765
95BMPR1B0.61634403
96CSNK1A1L0.60436071
97EPHB20.60040170
98MAPKAPK20.60006118
99FRK0.59791165
100NUAK10.59430298
101NEK60.58481417
102GSK3A0.58421212
103BCKDK0.58161731
104ABL10.56595181
105JAK20.56290501
106PRKCE0.55339339
107LYN0.54962627
108CSNK1G30.54874579
109OXSR10.54507410
110MAP3K20.53720267
111ZAK0.53656968
112CLK10.53332155
113BTK0.52603305
114CHUK0.51543482
115HCK0.50767228
116MAP3K110.50593528
117LRRK20.50332678
118BMPR20.49256059
119EIF2AK20.48803890
120BLK0.48744806
121MET0.48580560
122MAPK130.47996380
123ABL20.47768726
124FES0.45839778
125MAP3K10.43038505
126PRKG10.42148229
127MAPKAPK30.40635473
128MKNK20.40129494
129ADRBK10.39258456
130PKN10.38908774
131YES10.38353768
132LMTK20.38310299
133PTK2B0.36066078
134MAPK40.35894863
135PRKD10.35289855
136IRAK10.35037699
137PTK60.34408833
138PIM10.34229674
139INSR0.33566232
140PRKCQ0.32450866
141SGK20.32246069
142FER0.29989448

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.18248355
2Type I diabetes mellitus_Homo sapiens_hsa049402.58425689
3Staphylococcus aureus infection_Homo sapiens_hsa051502.36480203
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19549260
5Osteoclast differentiation_Homo sapiens_hsa043802.14674828
6Complement and coagulation cascades_Homo sapiens_hsa046102.06362990
7Graft-versus-host disease_Homo sapiens_hsa053322.02100365
8Hematopoietic cell lineage_Homo sapiens_hsa046401.98312358
9Other glycan degradation_Homo sapiens_hsa005111.92622731
10Collecting duct acid secretion_Homo sapiens_hsa049661.92516912
11Leishmaniasis_Homo sapiens_hsa051401.85311232
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.84956806
13Malaria_Homo sapiens_hsa051441.79617740
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.75058205
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.70610819
16Pertussis_Homo sapiens_hsa051331.69037090
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.66016166
18B cell receptor signaling pathway_Homo sapiens_hsa046621.65059698
19Primary immunodeficiency_Homo sapiens_hsa053401.59823927
20Mineral absorption_Homo sapiens_hsa049781.58067206
21Phagosome_Homo sapiens_hsa041451.57828754
22Rheumatoid arthritis_Homo sapiens_hsa053231.57637899
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52522136
24Antigen processing and presentation_Homo sapiens_hsa046121.52441613
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.49943319
26Toxoplasmosis_Homo sapiens_hsa051451.47573108
27Sphingolipid metabolism_Homo sapiens_hsa006001.43500199
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.41356421
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41096113
30Adherens junction_Homo sapiens_hsa045201.40363726
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.39061273
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.36658734
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35398378
34Platelet activation_Homo sapiens_hsa046111.34747242
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33475115
36Measles_Homo sapiens_hsa051621.29249294
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25134383
38Focal adhesion_Homo sapiens_hsa045101.24691987
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.22722750
40Tryptophan metabolism_Homo sapiens_hsa003801.20725919
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19037289
42Linoleic acid metabolism_Homo sapiens_hsa005911.18238765
43ECM-receptor interaction_Homo sapiens_hsa045121.16719565
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.15895331
45Viral myocarditis_Homo sapiens_hsa054161.15812746
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14881336
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10943968
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09219796
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09083347
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08103701
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07463152
52Dilated cardiomyopathy_Homo sapiens_hsa054141.06889705
53Legionellosis_Homo sapiens_hsa051341.05578764
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04423743
55Starch and sucrose metabolism_Homo sapiens_hsa005001.04203607
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03773653
57Renal cell carcinoma_Homo sapiens_hsa052111.02762818
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01952289
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01620428
60TNF signaling pathway_Homo sapiens_hsa046681.00970499
61Sulfur metabolism_Homo sapiens_hsa009200.99206543
62Tuberculosis_Homo sapiens_hsa051520.97413677
63Salmonella infection_Homo sapiens_hsa051320.96402875
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94687308
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94285383
66Vitamin digestion and absorption_Homo sapiens_hsa049770.93611704
67Apoptosis_Homo sapiens_hsa042100.93520569
68Fatty acid degradation_Homo sapiens_hsa000710.89278987
69PPAR signaling pathway_Homo sapiens_hsa033200.87764310
70Influenza A_Homo sapiens_hsa051640.87577990
71Lysosome_Homo sapiens_hsa041420.87237148
72Hepatitis B_Homo sapiens_hsa051610.87070100
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86795790
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.85228936
75Chemical carcinogenesis_Homo sapiens_hsa052040.83392084
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83352943
77Caffeine metabolism_Homo sapiens_hsa002320.82332305
78T cell receptor signaling pathway_Homo sapiens_hsa046600.81907712
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80682835
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80370081
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79768717
82HIF-1 signaling pathway_Homo sapiens_hsa040660.79735503
83Butanoate metabolism_Homo sapiens_hsa006500.78266569
84Rap1 signaling pathway_Homo sapiens_hsa040150.77340377
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76979636
86Allograft rejection_Homo sapiens_hsa053300.75551346
87ABC transporters_Homo sapiens_hsa020100.75334980
88Autoimmune thyroid disease_Homo sapiens_hsa053200.74547193
89Hepatitis C_Homo sapiens_hsa051600.72393770
90Tyrosine metabolism_Homo sapiens_hsa003500.72006150
91Chemokine signaling pathway_Homo sapiens_hsa040620.72004199
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71313275
93African trypanosomiasis_Homo sapiens_hsa051430.69795743
94TGF-beta signaling pathway_Homo sapiens_hsa043500.69720453
95Regulation of autophagy_Homo sapiens_hsa041400.69697487
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69671105
97Pancreatic cancer_Homo sapiens_hsa052120.68959815
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68803521
99Ether lipid metabolism_Homo sapiens_hsa005650.68665364
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68413976
101Dorso-ventral axis formation_Homo sapiens_hsa043200.68264197
102Histidine metabolism_Homo sapiens_hsa003400.66644125
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66158706
104FoxO signaling pathway_Homo sapiens_hsa040680.65825188
105Peroxisome_Homo sapiens_hsa041460.65811063
106Protein export_Homo sapiens_hsa030600.64425403
107Small cell lung cancer_Homo sapiens_hsa052220.63826210
108Insulin resistance_Homo sapiens_hsa049310.63588014
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63046016
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.61980639
111Arachidonic acid metabolism_Homo sapiens_hsa005900.61881637
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61466601
113Amoebiasis_Homo sapiens_hsa051460.61310410
114Herpes simplex infection_Homo sapiens_hsa051680.60184862
115Propanoate metabolism_Homo sapiens_hsa006400.60008259
116Renin secretion_Homo sapiens_hsa049240.59983269
117Endocytosis_Homo sapiens_hsa041440.58125715
118Notch signaling pathway_Homo sapiens_hsa043300.57674705
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56355504
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55022074
121Nitrogen metabolism_Homo sapiens_hsa009100.54550731
122Gastric acid secretion_Homo sapiens_hsa049710.54353520
123beta-Alanine metabolism_Homo sapiens_hsa004100.54183899
124Oxidative phosphorylation_Homo sapiens_hsa001900.53361262
125Ras signaling pathway_Homo sapiens_hsa040140.52344351
126Protein digestion and absorption_Homo sapiens_hsa049740.52114140
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51309464
128Retinol metabolism_Homo sapiens_hsa008300.50745350
129Oxytocin signaling pathway_Homo sapiens_hsa049210.50741518
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50667750
131Chronic myeloid leukemia_Homo sapiens_hsa052200.50192667
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48501539
133MAPK signaling pathway_Homo sapiens_hsa040100.48311914
134Shigellosis_Homo sapiens_hsa051310.48160206
135Ovarian steroidogenesis_Homo sapiens_hsa049130.47069096
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.46860214
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40639976
138Salivary secretion_Homo sapiens_hsa049700.39401907
139Serotonergic synapse_Homo sapiens_hsa047260.38194271
140Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38109515
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36103470
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35230141
143Phototransduction_Homo sapiens_hsa047440.33728865
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.32430326

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