ST6GAL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)7.62245259
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.49018403
3L-phenylalanine catabolic process (GO:0006559)6.49018403
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.08429679
5L-phenylalanine metabolic process (GO:0006558)6.08429679
6alpha-linolenic acid metabolic process (GO:0036109)5.97759619
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.92138475
8aromatic amino acid family catabolic process (GO:0009074)5.83727312
9negative regulation of fibrinolysis (GO:0051918)5.29069870
10kynurenine metabolic process (GO:0070189)5.27252303
11indole-containing compound catabolic process (GO:0042436)5.22347887
12indolalkylamine catabolic process (GO:0046218)5.22347887
13tryptophan catabolic process (GO:0006569)5.22347887
14high-density lipoprotein particle remodeling (GO:0034375)5.14190265
15complement activation, alternative pathway (GO:0006957)4.94069152
16tryptophan metabolic process (GO:0006568)4.92675427
17regulation of fibrinolysis (GO:0051917)4.90740329
18peptidyl-glutamic acid carboxylation (GO:0017187)4.88178952
19protein carboxylation (GO:0018214)4.88178952
20urea metabolic process (GO:0019627)4.87944032
21urea cycle (GO:0000050)4.87944032
22bile acid biosynthetic process (GO:0006699)4.87641042
23regulation of protein activation cascade (GO:2000257)4.86322593
24positive regulation of gamma-delta T cell activation (GO:0046645)4.85467209
25reverse cholesterol transport (GO:0043691)4.76256357
26glyoxylate metabolic process (GO:0046487)4.74591872
27B cell receptor signaling pathway (GO:0050853)4.67254303
28sulfur amino acid catabolic process (GO:0000098)4.55727458
29phospholipid efflux (GO:0033700)4.52327620
30regulation of complement activation (GO:0030449)4.52056871
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.51578078
32complement activation, classical pathway (GO:0006958)4.48732526
33cysteine metabolic process (GO:0006534)4.43823851
34regulation of cholesterol esterification (GO:0010872)4.42754788
35nitrogen cycle metabolic process (GO:0071941)4.41822046
36negative regulation of cholesterol transport (GO:0032375)4.37210994
37negative regulation of sterol transport (GO:0032372)4.37210994
38regulation of triglyceride catabolic process (GO:0010896)4.34170801
39tyrosine metabolic process (GO:0006570)4.33983064
40plasma lipoprotein particle remodeling (GO:0034369)4.31851865
41protein-lipid complex remodeling (GO:0034368)4.31851865
42macromolecular complex remodeling (GO:0034367)4.31851865
43bile acid metabolic process (GO:0008206)4.29107757
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.26632091
45complement activation (GO:0006956)4.24189837
46plasma lipoprotein particle clearance (GO:0034381)4.22454080
47aromatic amino acid family metabolic process (GO:0009072)4.15635499
48regulation of B cell receptor signaling pathway (GO:0050855)4.14146559
49serine family amino acid catabolic process (GO:0009071)4.06143522
50blood coagulation, intrinsic pathway (GO:0007597)4.04321947
51cholesterol efflux (GO:0033344)4.01319898
52triglyceride homeostasis (GO:0070328)3.98204906
53acylglycerol homeostasis (GO:0055090)3.98204906
54phospholipid homeostasis (GO:0055091)3.97621522
55regulation of apoptotic cell clearance (GO:2000425)3.89468382
56ethanol oxidation (GO:0006069)3.84727230
57plasma lipoprotein particle assembly (GO:0034377)3.84495092
58protein activation cascade (GO:0072376)3.84189569
59regulation of cholesterol homeostasis (GO:2000188)3.75204873
60homocysteine metabolic process (GO:0050667)3.73980368
61negative thymic T cell selection (GO:0045060)3.73824973
62regulation of gamma-delta T cell activation (GO:0046643)3.72310604
63cellular ketone body metabolic process (GO:0046950)3.72310538
64lysine metabolic process (GO:0006553)3.70137540
65lysine catabolic process (GO:0006554)3.70137540
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.69699952
67protein-lipid complex assembly (GO:0065005)3.67558583
68bile acid and bile salt transport (GO:0015721)3.67433537
69alpha-amino acid catabolic process (GO:1901606)3.67088722
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64699111
71benzene-containing compound metabolic process (GO:0042537)3.63511080
72dicarboxylic acid biosynthetic process (GO:0043650)3.63181732
73negative regulation of cell killing (GO:0031342)3.62360036
74negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.62360036
75low-density lipoprotein particle remodeling (GO:0034374)3.61437134
76regulation of gamma-delta T cell differentiation (GO:0045586)3.61032828
77positive regulation of B cell differentiation (GO:0045579)3.60343907
78negative T cell selection (GO:0043383)3.59646159
79fibrinolysis (GO:0042730)3.58111769
80indolalkylamine metabolic process (GO:0006586)3.57592226
81positive regulation of lipoprotein lipase activity (GO:0051006)3.56701941
82positive regulation of triglyceride lipase activity (GO:0061365)3.56701941
83positive regulation of lipid catabolic process (GO:0050996)3.55956402
84exogenous drug catabolic process (GO:0042738)3.54197323
85positive regulation of humoral immune response (GO:0002922)3.52146047
86amino-acid betaine metabolic process (GO:0006577)3.47744845
87cellular glucuronidation (GO:0052695)3.47156775
88regulation of cholesterol biosynthetic process (GO:0045540)3.47129337
89glycine metabolic process (GO:0006544)3.46850389
90very-low-density lipoprotein particle assembly (GO:0034379)3.45198099
91positive regulation of fatty acid beta-oxidation (GO:0032000)3.42661557
92epoxygenase P450 pathway (GO:0019373)3.41031231
93plasma lipoprotein particle organization (GO:0071827)3.40734494
94glutamate metabolic process (GO:0006536)3.40132840
95acute-phase response (GO:0006953)3.39888945
96negative regulation of protein activation cascade (GO:2000258)3.39706538
97cellular biogenic amine catabolic process (GO:0042402)3.38377343
98amine catabolic process (GO:0009310)3.38377343
99positive thymic T cell selection (GO:0045059)3.38120661
100cholesterol homeostasis (GO:0042632)3.37310274
101cellular modified amino acid catabolic process (GO:0042219)3.37212089
102ketone body metabolic process (GO:1902224)3.36535361
103drug catabolic process (GO:0042737)3.36263408
104acetyl-CoA metabolic process (GO:0006084)3.36090516
105linoleic acid metabolic process (GO:0043651)3.35887432
106cellular amino acid catabolic process (GO:0009063)3.35553481
107protein-lipid complex subunit organization (GO:0071825)3.33723657
108CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.33299122
109sterol homeostasis (GO:0055092)3.33021199
110imidazole-containing compound metabolic process (GO:0052803)3.31624763
111negative regulation of lipase activity (GO:0060192)3.30585023
112lipoprotein metabolic process (GO:0042157)3.29790379
113thymic T cell selection (GO:0045061)3.25261198
114regulation of cholesterol metabolic process (GO:0090181)3.25209790
115response to interleukin-15 (GO:0070672)3.21702660
116detection of bacterium (GO:0016045)3.21508022
117serine family amino acid metabolic process (GO:0009069)3.21449931
118regulation of humoral immune response (GO:0002920)3.20114708
119T cell migration (GO:0072678)3.19716464
120coenzyme catabolic process (GO:0009109)3.17352803
121regulation of fatty acid beta-oxidation (GO:0031998)3.16689465
122positive regulation of triglyceride metabolic process (GO:0090208)3.16418041
123regulation of B cell differentiation (GO:0045577)3.15244372
124short-chain fatty acid metabolic process (GO:0046459)3.14576079
125antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13537484
126antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13537484
127antigen processing and presentation of endogenous antigen (GO:0019883)3.12658640
128arginine metabolic process (GO:0006525)3.11228478
129B cell homeostasis (GO:0001782)3.08651444
130detection of other organism (GO:0098543)3.08235473
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08070031
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08070031
133positive regulation by organism of defense response of other organism involved in symbiotic interact3.08070031
134modulation by symbiont of host immune response (GO:0052553)3.08070031
135positive regulation by symbiont of host defense response (GO:0052509)3.08070031
136modulation by symbiont of host defense response (GO:0052031)3.08070031
137negative regulation of humoral immune response (GO:0002921)3.04055638
138germinal center formation (GO:0002467)3.01274195
139histone H3-K36 demethylation (GO:0070544)2.97957523
140omega-hydroxylase P450 pathway (GO:0097267)2.96979083
141T cell selection (GO:0045058)2.94455693
142ethanol metabolic process (GO:0006067)2.88712785
143detection of external biotic stimulus (GO:0098581)2.86951461
144positive regulation of blood coagulation (GO:0030194)2.86535994
145positive regulation of hemostasis (GO:1900048)2.86535994
146positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.81857198
147positive T cell selection (GO:0043368)2.80701532
148immunoglobulin mediated immune response (GO:0016064)2.77692662
149negative regulation of lymphocyte mediated immunity (GO:0002707)2.76501258
150cytolysis (GO:0019835)2.76419113
151regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73391905
152positive regulation of immunoglobulin mediated immune response (GO:0002891)2.71444865
153positive regulation of B cell mediated immunity (GO:0002714)2.71444865
154negative regulation of hemostasis (GO:1900047)2.69707471
155negative regulation of blood coagulation (GO:0030195)2.69707471
156cellular response to type I interferon (GO:0071357)2.69259128
157type I interferon signaling pathway (GO:0060337)2.69259128

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.38429619
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.76506238
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.99808845
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.45357556
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.15396356
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.09300250
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.83607157
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.72657244
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.46148923
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.00185625
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.95541631
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54045386
13CLOCK_20551151_ChIP-Seq_293T_Human2.23011118
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.11822529
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.11784101
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07154660
17SCL_19346495_ChIP-Seq_HPC-7_Human1.89222276
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.89192814
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.81921918
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81754313
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78194002
22SPI1_23547873_ChIP-Seq_NB4_Human1.71049974
23* FOXA2_19822575_ChIP-Seq_HepG2_Human1.68981201
24RUNX1_22412390_ChIP-Seq_EML_Mouse1.64242216
25* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63813575
26* SPI1_23127762_ChIP-Seq_K562_Human1.63622614
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62687794
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60575828
29RUNX_20019798_ChIP-Seq_JUKART_Human1.57306978
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57262252
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56578113
32MYC_22102868_ChIP-Seq_BL_Human1.53736099
33CIITA_25753668_ChIP-Seq_RAJI_Human1.52307768
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.50541504
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50372229
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47585830
37HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.47505058
38GATA1_22025678_ChIP-Seq_K562_Human1.45077314
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44761702
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44331818
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38924046
42GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38106429
43* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33342116
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30585008
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27593348
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.24921326
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24144011
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22222827
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22163074
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.20716265
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.19150575
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17318675
53* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15575240
54MAF_26560356_Chip-Seq_TH1_Human1.15044591
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13338990
56* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11258722
57* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09550991
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.07898790
59* NCOR1_26117541_ChIP-Seq_K562_Human1.07730259
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07720141
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06263309
62MYB_26560356_Chip-Seq_TH1_Human1.04237417
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01592553
64VDR_21846776_ChIP-Seq_THP-1_Human1.00588013
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00359722
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98652784
67LXR_22292898_ChIP-Seq_THP-1_Human0.98176204
68UTX_26944678_Chip-Seq_JUKART_Human0.97703028
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97536398
70TCF7_22412390_ChIP-Seq_EML_Mouse0.97414430
71* GATA1_19941826_ChIP-Seq_K562_Human0.96683676
72MYB_26560356_Chip-Seq_TH2_Human0.94958719
73* GATA3_26560356_Chip-Seq_TH2_Human0.94054337
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90970804
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90610030
76SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90442037
77GATA4_25053715_ChIP-Seq_YYC3_Human0.90375954
78* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90298158
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88222908
80CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87803264
81KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87357190
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87339887
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86902743
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86381794
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.85790045
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85559112
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85461208
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85292239
89* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84897827
90E2F7_22180533_ChIP-Seq_HELA_Human0.84751251
91KDM2B_26808549_Chip-Seq_DND41_Human0.84462107
92EGR1_19374776_ChIP-ChIP_THP-1_Human0.84015608
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83838906
94* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83789409
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83692533
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83504042
97VDR_24787735_ChIP-Seq_THP-1_Human0.83470358
98CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83425525
99ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83104467
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82437834
101BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81896617
102ZNF263_19887448_ChIP-Seq_K562_Human0.81447569
103* GATA2_19941826_ChIP-Seq_K562_Human0.81129433
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.80870352
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78402396
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77708933
107* GATA3_27048872_Chip-Seq_THYMUS_Human0.77160835
108* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76241425
109TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76192959
110TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75390590
111VDR_24763502_ChIP-Seq_THP-1_Human0.74837037
112KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74692939
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.74134423
114FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73717773
115GATA6_25053715_ChIP-Seq_YYC3_Human0.73441215
116* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.71488083
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.69319253
118* FOXA1_25552417_ChIP-Seq_VCAP_Human0.69164799
119RACK7_27058665_Chip-Seq_MCF-7_Human0.68890843
120* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.68384782
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.68332232
122* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.66629502
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.66390631
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.66070482
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.65897071
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.64803997
127MAF_26560356_Chip-Seq_TH2_Human0.64296819
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.63354259
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63323625
130PU_27001747_Chip-Seq_BMDM_Mouse0.63015139
131STAT4_19710469_ChIP-ChIP_TH1__Mouse0.62776603
132* TBX20_22328084_ChIP-Seq_HEART_Mouse0.62295422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.13205661
2MP0005360_urolithiasis6.29633379
3MP0005085_abnormal_gallbladder_physiolo5.20133796
4MP0005365_abnormal_bile_salt5.12940458
5MP0008875_abnormal_xenobiotic_pharmacok3.93620480
6MP0009840_abnormal_foam_cell3.49052239
7MP0003252_abnormal_bile_duct3.47449773
8MP0010329_abnormal_lipoprotein_level3.14241918
9MP0005083_abnormal_biliary_tract3.01407004
10MP0003806_abnormal_nucleotide_metabolis2.98930629
11MP0003191_abnormal_cellular_cholesterol2.53573862
12MP0002138_abnormal_hepatobiliary_system2.47360720
13MP0003195_calcinosis2.35924988
14MP0001666_abnormal_nutrient_absorption2.33903815
15MP0000609_abnormal_liver_physiology2.23677382
16MP0005332_abnormal_amino_acid2.22284711
17MP0009333_abnormal_splenocyte_physiolog2.11700155
18MP0003300_gastrointestinal_ulcer2.04193880
19MP0002118_abnormal_lipid_homeostasis1.89051639
20MP0002132_abnormal_respiratory_system1.68997162
21MP0003868_abnormal_feces_composition1.64582470
22MP0004019_abnormal_vitamin_homeostasis1.63977116
23MP0002396_abnormal_hematopoietic_system1.63114306
24MP0003705_abnormal_hypodermis_morpholog1.57638278
25MP0001835_abnormal_antigen_presentation1.55243146
26MP0005387_immune_system_phenotype1.49129228
27MP0001790_abnormal_immune_system1.49129228
28MP0002254_reproductive_system_inflammat1.48403796
29MP0000604_amyloidosis1.47511195
30MP0001800_abnormal_humoral_immune1.47397841
31MP0005319_abnormal_enzyme/_coenzyme1.45347273
32MP0003172_abnormal_lysosome_physiology1.44465336
33MP0005584_abnormal_enzyme/coenzyme_acti1.42928877
34MP0008057_abnormal_DNA_replication1.40666526
35MP0001881_abnormal_mammary_gland1.39188907
36MP0009643_abnormal_urine_homeostasis1.36315110
37MP0000685_abnormal_immune_system1.36007003
38MP0000703_abnormal_thymus_morphology1.34091424
39MP0005408_hypopigmentation1.26032138
40MP0005310_abnormal_salivary_gland1.23630490
41MP0003183_abnormal_peptide_metabolism1.22787541
42MP0005451_abnormal_body_composition1.22450875
43MP0003436_decreased_susceptibility_to1.21127774
44MP0000598_abnormal_liver_morphology1.20888875
45MP0003866_abnormal_defecation1.18750832
46MP0010234_abnormal_vibrissa_follicle1.16164618
47MP0002148_abnormal_hypersensitivity_rea1.15699516
48MP0001915_intracranial_hemorrhage1.12962777
49MP0008260_abnormal_autophagy1.12004739
50MP0005058_abnormal_lysosome_morphology1.11002844
51MP0008469_abnormal_protein_level1.10301356
52MP0010368_abnormal_lymphatic_system1.08528614
53MP0003656_abnormal_erythrocyte_physiolo1.07971499
54MP0005464_abnormal_platelet_physiology1.06394819
55* MP0003303_peritoneal_inflammation1.05833175
56MP0002006_tumorigenesis1.05403945
57MP0000858_altered_metastatic_potential1.03498943
58MP0009763_increased_sensitivity_to1.02800759
59MP0004947_skin_inflammation1.02072931
60* MP0002452_abnormal_antigen_presenting1.00121303
61MP0003690_abnormal_glial_cell0.99585205
62MP0004264_abnormal_extraembryonic_tissu0.99129868
63MP0006082_CNS_inflammation0.96094951
64MP0002723_abnormal_immune_serum0.94833239
65MP0001764_abnormal_homeostasis0.93559662
66MP0001661_extended_life_span0.93290760
67MP0000465_gastrointestinal_hemorrhage0.92508362
68MP0003011_delayed_dark_adaptation0.91897742
69MP0004883_abnormal_blood_vessel0.91198286
70MP0009764_decreased_sensitivity_to0.90310480
71MP0004130_abnormal_muscle_cell0.90175205
72* MP0001845_abnormal_inflammatory_respons0.89286396
73MP0002166_altered_tumor_susceptibility0.89219440
74MP0001851_eye_inflammation0.87613504
75MP0009642_abnormal_blood_homeostasis0.85268829
76MP0005670_abnormal_white_adipose0.84424802
77MP0005000_abnormal_immune_tolerance0.84071897
78MP0002136_abnormal_kidney_physiology0.83886043
79MP0001873_stomach_inflammation0.83408582
80MP0005647_abnormal_sex_gland0.82952477
81MP0005220_abnormal_exocrine_pancreas0.81649305
82* MP0002419_abnormal_innate_immunity0.81559131
83MP0002078_abnormal_glucose_homeostasis0.79682751
84MP0003091_abnormal_cell_migration0.78456265
85MP0000639_abnormal_adrenal_gland0.78040592
86MP0002998_abnormal_bone_remodeling0.77560974
87MP0002928_abnormal_bile_duct0.77516645
88MP0009697_abnormal_copulation0.76529626
89MP0003763_abnormal_thymus_physiology0.74982778
90* MP0005025_abnormal_response_to0.74869913
91* MP0002420_abnormal_adaptive_immunity0.74265088
92MP0002019_abnormal_tumor_incidence0.73348297
93* MP0001819_abnormal_immune_cell0.73084624
94MP0001853_heart_inflammation0.72348341
95MP0005636_abnormal_mineral_homeostasis0.71743233
96* MP0000689_abnormal_spleen_morphology0.71127330
97MP0005671_abnormal_response_to0.70041127
98MP0004043_abnormal_pH_regulation0.69528365
99MP0002009_preneoplasia0.69307377
100MP0004185_abnormal_adipocyte_glucose0.68908643
101MP0005334_abnormal_fat_pad0.67890047
102MP0002971_abnormal_brown_adipose0.66590022
103* MP0000716_abnormal_immune_system0.66342492
104MP0009115_abnormal_fat_cell0.66140269
105MP0001756_abnormal_urination0.65685697
106MP0009765_abnormal_xenobiotic_induced0.65268528
107MP0004808_abnormal_hematopoietic_stem0.64359930
108MP0003186_abnormal_redox_activity0.64282969
109MP0003329_amyloid_beta_deposits0.63737704
110MP0003566_abnormal_cell_adhesion0.63678329
111MP0001545_abnormal_hematopoietic_system0.63381333
112MP0005397_hematopoietic_system_phenotyp0.63381333
113MP0010155_abnormal_intestine_physiology0.60892624
114MP0008874_decreased_physiological_sensi0.60847649
115MP0000249_abnormal_blood_vessel0.57848607
116MP0005023_abnormal_wound_healing0.56515226
117MP0005075_abnormal_melanosome_morpholog0.56246220
118MP0001348_abnormal_lacrimal_gland0.56227949
119MP0003724_increased_susceptibility_to0.56107890
120MP0009785_altered_susceptibility_to0.55569110
121* MP0002398_abnormal_bone_marrow0.55485839
122MP0003453_abnormal_keratinocyte_physiol0.54329793
123MP0008961_abnormal_basal_metabolism0.53020850
124MP0002722_abnormal_immune_system0.52722205
125* MP0002429_abnormal_blood_cell0.50517358
126MP0005666_abnormal_adipose_tissue0.50209150
127MP0004381_abnormal_hair_follicle0.49354030
128MP0009053_abnormal_anal_canal0.47829556
129MP0001533_abnormal_skeleton_physiology0.47504844
130MP0002933_joint_inflammation0.47409248
131MP0002405_respiratory_system_inflammati0.47285241
132MP0005166_decreased_susceptibility_to0.47088543

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.21242733
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.02302386
3Intrahepatic cholestasis (HP:0001406)5.99570386
4Xanthomatosis (HP:0000991)5.68725088
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.54890407
6Prolonged partial thromboplastin time (HP:0003645)5.34650598
7Hypobetalipoproteinemia (HP:0003563)5.14027536
8Complement deficiency (HP:0004431)5.11208235
9Hyperlipoproteinemia (HP:0010980)4.94337295
10Abnormality of the common coagulation pathway (HP:0010990)4.32339937
11Joint hemorrhage (HP:0005261)4.30778050
12Epidermoid cyst (HP:0200040)4.17603934
13Hypolipoproteinemia (HP:0010981)3.97740921
14Gastrointestinal stroma tumor (HP:0100723)3.82558298
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.74011340
16Abnormality of complement system (HP:0005339)3.70868342
17Meningitis (HP:0001287)3.69540965
18Myocardial infarction (HP:0001658)3.65540227
19Hypoalphalipoproteinemia (HP:0003233)3.61853626
20Hyperammonemia (HP:0001987)3.54967335
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.53281193
22Ketosis (HP:0001946)3.52046743
23Fat malabsorption (HP:0002630)3.42659585
24Hypoglycemic coma (HP:0001325)3.33325331
25Abnormality of the intrinsic pathway (HP:0010989)3.33020966
26Hypercholesterolemia (HP:0003124)3.30023711
27Purpura (HP:0000979)3.24555604
28Eczematoid dermatitis (HP:0000976)3.23895616
29Abnormality of methionine metabolism (HP:0010901)3.22071966
30Abnormality of glutamine family amino acid metabolism (HP:0010902)3.21735111
31Mitral stenosis (HP:0001718)3.21032915
32Hyperglycinemia (HP:0002154)3.20284557
33Conjugated hyperbilirubinemia (HP:0002908)3.11134965
34Vasculitis (HP:0002633)3.10719700
35Systemic lupus erythematosus (HP:0002725)3.08692925
36Abnormality of aspartate family amino acid metabolism (HP:0010899)3.04949089
37Glomerulonephritis (HP:0000099)3.03918888
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.01743326
39Epistaxis (HP:0000421)2.99473849
40Panhypogammaglobulinemia (HP:0003139)2.90449058
41Hepatocellular carcinoma (HP:0001402)2.90237626
42Mediastinal lymphadenopathy (HP:0100721)2.85090740
43Cellulitis (HP:0100658)2.81240707
44Lymphopenia (HP:0001888)2.78831637
45IgM deficiency (HP:0002850)2.77434047
46Abnormality of serine family amino acid metabolism (HP:0010894)2.77372242
47Abnormality of glycine metabolism (HP:0010895)2.77372242
48Gastrointestinal infarctions (HP:0005244)2.76169767
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.74467318
50Prolonged bleeding time (HP:0003010)2.74282839
51Gingival bleeding (HP:0000225)2.71832414
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.67749080
53Hyperglycinuria (HP:0003108)2.67146619
54Abnormality of pyrimidine metabolism (HP:0004353)2.67058283
55Esophageal varix (HP:0002040)2.66145745
56Recurrent gram-negative bacterial infections (HP:0005420)2.64643527
57Ketoacidosis (HP:0001993)2.63139288
58Abnormality of nucleobase metabolism (HP:0010932)2.58606065
59Spontaneous abortion (HP:0005268)2.54620319
60Abnormality of purine metabolism (HP:0004352)2.54379956
61Recurrent abscess formation (HP:0002722)2.54290120
62Recurrent otitis media (HP:0000403)2.53808257
63Agammaglobulinemia (HP:0004432)2.53397356
64Recurrent fungal infections (HP:0002841)2.53288833
65Chronic mucocutaneous candidiasis (HP:0002728)2.53030682
66Recurrent cutaneous fungal infections (HP:0011370)2.53030682
67Recurrent bacterial skin infections (HP:0005406)2.53021472
68Skin nodule (HP:0200036)2.52587390
69Hyperbilirubinemia (HP:0002904)2.50354162
70Steatorrhea (HP:0002570)2.49269121
71Retrobulbar optic neuritis (HP:0100654)2.47624927
72Optic neuritis (HP:0100653)2.47624927
73Colitis (HP:0002583)2.46063909
74Hypoglycemic seizures (HP:0002173)2.45994156
75Hypochromic microcytic anemia (HP:0004840)2.45814811
76IgA deficiency (HP:0002720)2.45461254
77Abnormality of macrophages (HP:0004311)2.44691939
78Nephritis (HP:0000123)2.43026228
79Bronchitis (HP:0012387)2.42782333
80Abnormality of fatty-acid metabolism (HP:0004359)2.41771003
81Encephalitis (HP:0002383)2.41065410
82Vascular calcification (HP:0004934)2.39635265
83Recurrent skin infections (HP:0001581)2.32123296
84Abnormal platelet function (HP:0011869)2.29689528
85Impaired platelet aggregation (HP:0003540)2.29689528
86Myositis (HP:0100614)2.28073033
87Orchitis (HP:0100796)2.27407817
88Emphysema (HP:0002097)2.25165504
89Chronic obstructive pulmonary disease (HP:0006510)2.23460777
90Obstructive lung disease (HP:0006536)2.23460777
91Osteomyelitis (HP:0002754)2.18772504
92T lymphocytopenia (HP:0005403)2.17515585
93Thrombophlebitis (HP:0004418)2.14199384
94Late onset (HP:0003584)2.13761217
95Pulmonary infiltrates (HP:0002113)2.13086025
96Hemorrhage of the eye (HP:0011885)2.12961397
97Pulmonary embolism (HP:0002204)2.12796182
98Spastic diplegia (HP:0001264)2.12381457
99Amyloidosis (HP:0011034)2.11236613
100Cardiovascular calcification (HP:0011915)2.11079529
101Recurrent pneumonia (HP:0006532)2.10583359
102Verrucae (HP:0200043)2.10557104
103Papilloma (HP:0012740)2.10557104
104Abnormality of T cell number (HP:0011839)2.10034940
105Viral hepatitis (HP:0006562)2.07844013
106Acanthocytosis (HP:0001927)2.06850611
107Abnormality of T cells (HP:0002843)2.06783793
108Abnormal tarsal ossification (HP:0008369)2.05619314
109Gout (HP:0001997)2.04700036
110Abnormality of the peritoneum (HP:0002585)2.03580734
111Acute hepatic failure (HP:0006554)2.03447624
112Menorrhagia (HP:0000132)2.02856813
113Arterial thrombosis (HP:0004420)2.02836270
114Increased IgE level (HP:0003212)2.01747364
115Sensorimotor neuropathy (HP:0007141)2.01209853
116Abnormality of endocrine pancreas physiology (HP:0012093)2.00091275
117Abnormality of the pancreatic islet cells (HP:0006476)2.00091275
118Chronic otitis media (HP:0000389)1.99334921
119Abnormality of the fingertips (HP:0001211)1.98712795
120Recurrent lower respiratory tract infections (HP:0002783)1.98662655
121Gangrene (HP:0100758)1.98378043
122Abnormality of T cell physiology (HP:0011840)1.96744174
123Hyperinsulinemic hypoglycemia (HP:0000825)1.96076233
124Joint swelling (HP:0001386)1.95590481
125Skin rash (HP:0000988)1.94900568
126Recurrent sinusitis (HP:0011108)1.94559822
127Hypochromic anemia (HP:0001931)1.93217339
128Autoimmune hemolytic anemia (HP:0001890)1.93054889
129Increased CSF protein (HP:0002922)1.93015452
130Irritability (HP:0000737)1.92974884
131Delayed CNS myelination (HP:0002188)1.92768463
132Hyperactive renin-angiotensin system (HP:0000841)1.92336892
133Inflammation of the large intestine (HP:0002037)1.92130738
134Spontaneous hematomas (HP:0007420)1.92011052
135Small epiphyses (HP:0010585)1.89100503
136Abnormality of transition element cation homeostasis (HP:0011030)1.88870952
137Abnormality of serum amino acid levels (HP:0003112)1.88808556
138Restrictive lung disease (HP:0002091)1.87583852
139Lymphoma (HP:0002665)1.86074306
140Gastrointestinal inflammation (HP:0004386)1.85571989
141Chronic diarrhea (HP:0002028)1.85353190
142Back pain (HP:0003418)1.85142899
143Abnormality of iron homeostasis (HP:0011031)1.83662790
144Metabolic acidosis (HP:0001942)1.82568778
145Malnutrition (HP:0004395)1.81934073
146Peripheral demyelination (HP:0011096)1.80140945
147Pancreatitis (HP:0001733)1.79321906
148Abnormal gallbladder morphology (HP:0012437)1.78939616
149Polycythemia (HP:0001901)1.78212033
150Recurrent bronchitis (HP:0002837)1.77192163
151Glomerulosclerosis (HP:0000096)1.76129741
152Axonal loss (HP:0003447)1.74999795
153Abnormal enzyme/coenzyme activity (HP:0012379)1.73151198
154Focal segmental glomerulosclerosis (HP:0000097)1.71314123
155Increased mean platelet volume (HP:0011877)1.70411527
156Recurrent viral infections (HP:0004429)1.70060576
157Hepatitis (HP:0012115)1.67969630
158Elevated hepatic transaminases (HP:0002910)1.67347053
159Cholelithiasis (HP:0001081)1.67158603
160Neonatal onset (HP:0003623)1.66442969

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.21407721
2RIPK43.93332710
3PRPF4B3.81091558
4MAP4K13.63318328
5SIK13.62450531
6FGFR43.56143668
7TRIB33.30888538
8PKN22.89331900
9MAP3K102.77223765
10BCKDK2.58048885
11SMG12.19958326
12TYK22.15393627
13GRK62.14786657
14TAOK32.00771189
15PTK61.87404794
16CAMK1D1.75581827
17JAK11.73174154
18TGFBR21.67420126
19INSRR1.66081331
20EEF2K1.63996891
21FGFR21.62433813
22EPHB11.61626369
23STK101.59491429
24CSF1R1.52082685
25CAMK1G1.50817519
26IRAK41.50670475
27ITK1.49602573
28FES1.48307499
29MAP3K141.43969780
30LRRK21.41908483
31FGFR31.41533346
32TBK11.41314089
33MAP3K131.32483975
34JAK31.30145455
35ZAP701.29484215
36FRK1.23398213
37FLT31.23203030
38MAP3K71.21212152
39NEK91.17331727
40CSK1.16840392
41RIPK11.13913627
42TEC1.13392599
43EPHA31.12853469
44BLK1.11113602
45JAK21.10777364
46BTK1.07834049
47KDR1.02641341
48PIK3CG1.01557336
49LATS11.01488510
50IKBKE1.01412240
51MST1R1.00795763
52FGR1.00223219
53KSR21.00143610
54MAPK110.98394900
55SYK0.97239361
56SIK30.96339761
57CDC42BPA0.93319034
58PASK0.92158643
59PRKCQ0.89056304
60EIF2AK30.88128861
61MARK30.85891164
62PRKCH0.85611401
63MAP3K10.82461347
64MARK20.81879734
65PRKAA20.78163111
66TNK20.78144218
67DYRK1B0.77052668
68CHUK0.75416859
69YES10.75070115
70RET0.74796064
71SGK20.73795687
72HCK0.71980597
73CDK60.71512649
74MAPK150.69828717
75MET0.66813577
76LCK0.66244837
77SGK30.65981366
78NLK0.65453479
79BMPR20.62299736
80ERBB40.61845346
81SIK20.60815489
82PDGFRA0.60326928
83STK240.60305204
84MAPK120.60239553
85MAP3K30.60179025
86CDK120.60051060
87IKBKB0.57516633
88CSNK1A1L0.56995342
89LYN0.56165570
90GSK3A0.55653081
91PTK20.55459387
92MATK0.55248893
93CSNK1G10.54996647
94KIT0.54763201
95PDGFRB0.54279217
96MTOR0.53981531
97PRKD10.53972496
98BRD40.53818332
99MAPK70.53373932
100MAP3K20.53372100
101HIPK20.49923734
102EGFR0.49251247
103MST40.48184412
104MAPK40.47592785
105PDK10.47295572
106IGF1R0.46973813
107ALK0.46204541
108BMX0.46118022
109MAP3K80.45391320
110PRKCZ0.44723150
111ICK0.44110692
112SGK2230.44075503
113SGK4940.44075503
114MELK0.43558116
115TAOK20.42712626
116FYN0.41291078
117INSR0.40809693
118ABL10.40698226
119TXK0.40411829
120MAP2K30.39142466
121TYRO30.38860556
122CAMKK10.37864612
123IRAK10.37548135
124DAPK20.37499067
125CDK40.37164932
126PDPK10.37005211
127IRAK30.36886860
128PIM10.36867952
129CDK90.36648416
130MAP2K20.35143392
131PRKAA10.33480043
132MAPK30.28412208
133MAP3K50.26462772
134MAPKAPK20.26460676
135MAP3K110.26413655

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.13431046
2Nitrogen metabolism_Homo sapiens_hsa009103.81662067
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.28583142
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25020971
5Complement and coagulation cascades_Homo sapiens_hsa046103.00625043
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.93175357
7Arginine biosynthesis_Homo sapiens_hsa002202.76024149
8Autoimmune thyroid disease_Homo sapiens_hsa053202.65964270
9Tryptophan metabolism_Homo sapiens_hsa003802.54492425
10Allograft rejection_Homo sapiens_hsa053302.50549994
11Fatty acid degradation_Homo sapiens_hsa000712.40286270
12Caffeine metabolism_Homo sapiens_hsa002322.34703032
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28466239
14Staphylococcus aureus infection_Homo sapiens_hsa051502.26088397
15Graft-versus-host disease_Homo sapiens_hsa053322.22040768
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.16122247
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.15432260
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.02281618
19Fatty acid metabolism_Homo sapiens_hsa012121.93025001
20PPAR signaling pathway_Homo sapiens_hsa033201.91524492
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87392257
22Butanoate metabolism_Homo sapiens_hsa006501.86004014
23Peroxisome_Homo sapiens_hsa041461.78264398
24Histidine metabolism_Homo sapiens_hsa003401.76417814
25Type I diabetes mellitus_Homo sapiens_hsa049401.73524233
26Propanoate metabolism_Homo sapiens_hsa006401.71650435
27Chemical carcinogenesis_Homo sapiens_hsa052041.69753074
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.64858705
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62935416
30Asthma_Homo sapiens_hsa053101.61303315
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.60185537
32Selenocompound metabolism_Homo sapiens_hsa004501.58681392
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52054999
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46169256
35beta-Alanine metabolism_Homo sapiens_hsa004101.43828842
36Bile secretion_Homo sapiens_hsa049761.42915995
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40466248
38ABC transporters_Homo sapiens_hsa020101.37601767
39Retinol metabolism_Homo sapiens_hsa008301.36979953
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34698157
41Viral myocarditis_Homo sapiens_hsa054161.33991537
42Sulfur metabolism_Homo sapiens_hsa009201.30232419
43Fatty acid biosynthesis_Homo sapiens_hsa000611.29315391
44Steroid biosynthesis_Homo sapiens_hsa001001.28490366
45Tyrosine metabolism_Homo sapiens_hsa003501.27297451
46Phenylalanine metabolism_Homo sapiens_hsa003601.26654613
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.23439406
48Pyruvate metabolism_Homo sapiens_hsa006201.18593235
49Herpes simplex infection_Homo sapiens_hsa051681.15438778
50Fat digestion and absorption_Homo sapiens_hsa049751.12970119
51Influenza A_Homo sapiens_hsa051641.12131845
52Fatty acid elongation_Homo sapiens_hsa000621.10719031
53Lysine degradation_Homo sapiens_hsa003101.07418287
54Non-small cell lung cancer_Homo sapiens_hsa052231.07309278
55Starch and sucrose metabolism_Homo sapiens_hsa005001.06538882
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05467626
57Other glycan degradation_Homo sapiens_hsa005111.03352957
58Primary immunodeficiency_Homo sapiens_hsa053400.97147841
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93112414
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91362693
61Folate biosynthesis_Homo sapiens_hsa007900.88414616
62Tuberculosis_Homo sapiens_hsa051520.85487866
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83790755
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.82340887
65Sulfur relay system_Homo sapiens_hsa041220.82019897
66Biosynthesis of amino acids_Homo sapiens_hsa012300.81308690
67Systemic lupus erythematosus_Homo sapiens_hsa053220.76126041
68Carbon metabolism_Homo sapiens_hsa012000.75420115
69B cell receptor signaling pathway_Homo sapiens_hsa046620.74848294
70Hepatitis B_Homo sapiens_hsa051610.71279098
71Glycerolipid metabolism_Homo sapiens_hsa005610.70530480
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66178971
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65097105
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63749844
75Vitamin digestion and absorption_Homo sapiens_hsa049770.62215145
76Insulin resistance_Homo sapiens_hsa049310.61470586
77Chemokine signaling pathway_Homo sapiens_hsa040620.60742415
78Apoptosis_Homo sapiens_hsa042100.60697153
79Arginine and proline metabolism_Homo sapiens_hsa003300.60392871
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58953607
81Platelet activation_Homo sapiens_hsa046110.58822510
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.54016956
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52225155
84Epstein-Barr virus infection_Homo sapiens_hsa051690.50701705
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.49932818
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48746031
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.46558109
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46340494
89Viral carcinogenesis_Homo sapiens_hsa052030.45144731
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44993272
91Pentose phosphate pathway_Homo sapiens_hsa000300.44179522
92Prostate cancer_Homo sapiens_hsa052150.43878941
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43831713
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.42346757
95Endometrial cancer_Homo sapiens_hsa052130.41314135
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38921546
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.38510081
98HTLV-I infection_Homo sapiens_hsa051660.37249995
99Vitamin B6 metabolism_Homo sapiens_hsa007500.37157380
100Prion diseases_Homo sapiens_hsa050200.37118589
101One carbon pool by folate_Homo sapiens_hsa006700.36645596
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36002136
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35348402
104HIF-1 signaling pathway_Homo sapiens_hsa040660.35199373
105TNF signaling pathway_Homo sapiens_hsa046680.34867969
106Glutathione metabolism_Homo sapiens_hsa004800.32956813
107Inositol phosphate metabolism_Homo sapiens_hsa005620.32707975
108Renal cell carcinoma_Homo sapiens_hsa052110.32529550
109Choline metabolism in cancer_Homo sapiens_hsa052310.29710211
110Osteoclast differentiation_Homo sapiens_hsa043800.25424853
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23604737
112T cell receptor signaling pathway_Homo sapiens_hsa046600.23140338
113Lysosome_Homo sapiens_hsa041420.20360332
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20102707
115Galactose metabolism_Homo sapiens_hsa000520.20069974
116Prolactin signaling pathway_Homo sapiens_hsa049170.17314572
117Glucagon signaling pathway_Homo sapiens_hsa049220.17275037
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.17145907
119Hepatitis C_Homo sapiens_hsa051600.16625887
120AMPK signaling pathway_Homo sapiens_hsa041520.16399344
121* Metabolic pathways_Homo sapiens_hsa011000.14165676
122Antigen processing and presentation_Homo sapiens_hsa046120.13738686
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.09706219
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.09300025
125Leishmaniasis_Homo sapiens_hsa051400.07977642
126Measles_Homo sapiens_hsa051620.06958242
127Toxoplasmosis_Homo sapiens_hsa051450.06836734
128Pancreatic cancer_Homo sapiens_hsa052120.05496340
129Linoleic acid metabolism_Homo sapiens_hsa005910.05189547
130Pertussis_Homo sapiens_hsa051330.04913110
131Chronic myeloid leukemia_Homo sapiens_hsa052200.04868913
132Insulin signaling pathway_Homo sapiens_hsa049100.04494618
133Hematopoietic cell lineage_Homo sapiens_hsa046400.04361165
134Acute myeloid leukemia_Homo sapiens_hsa052210.02862320
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.01356314
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.00051910

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