ST6GAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to synapse (GO:0035418)6.16636467
2synaptic vesicle exocytosis (GO:0016079)5.97019456
3vocalization behavior (GO:0071625)5.78052134
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.60381068
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.54172240
6neuron cell-cell adhesion (GO:0007158)5.50674947
7response to pheromone (GO:0019236)5.45990206
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.35401408
9exploration behavior (GO:0035640)5.25630642
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24813301
11synaptic vesicle maturation (GO:0016188)5.13133089
12limb bud formation (GO:0060174)5.09092266
13locomotory exploration behavior (GO:0035641)5.04492590
14regulation of synaptic vesicle exocytosis (GO:2000300)5.03709863
15glutamate secretion (GO:0014047)4.98440315
16positive regulation of synapse maturation (GO:0090129)4.89641076
17layer formation in cerebral cortex (GO:0021819)4.78410626
18regulation of glutamate receptor signaling pathway (GO:1900449)4.75757340
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.64792229
20neurotransmitter-gated ion channel clustering (GO:0072578)4.50231646
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.28350871
22regulation of synaptic vesicle transport (GO:1902803)4.28161801
23glutamate receptor signaling pathway (GO:0007215)4.27891528
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24398745
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.22779403
26neuron recognition (GO:0008038)4.20991293
27postsynaptic membrane organization (GO:0001941)4.20316314
28regulation of synapse structural plasticity (GO:0051823)4.19140225
29dendritic spine morphogenesis (GO:0060997)4.17600265
30synaptic vesicle endocytosis (GO:0048488)4.12853819
31presynaptic membrane assembly (GO:0097105)4.10651750
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.08704769
33neurotransmitter secretion (GO:0007269)4.06919827
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.06600146
35synaptic transmission, glutamatergic (GO:0035249)4.02418784
36axonal fasciculation (GO:0007413)3.99790499
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.90769816
38neuron-neuron synaptic transmission (GO:0007270)3.89673071
39regulation of synapse maturation (GO:0090128)3.86971322
40positive regulation of dendritic spine morphogenesis (GO:0061003)3.85013695
41pyrimidine nucleobase catabolic process (GO:0006208)3.84230626
42proline transport (GO:0015824)3.81373010
43central nervous system projection neuron axonogenesis (GO:0021952)3.77039662
44dendrite morphogenesis (GO:0048813)3.74198386
45regulation of neuronal synaptic plasticity (GO:0048168)3.71796177
46positive regulation of membrane potential (GO:0045838)3.70801237
47regulation of dendritic spine morphogenesis (GO:0061001)3.67162226
48long-term synaptic potentiation (GO:0060291)3.64302622
49presynaptic membrane organization (GO:0097090)3.64041700
50innervation (GO:0060384)3.60939552
51regulation of excitatory postsynaptic membrane potential (GO:0060079)3.60731938
52neural tube formation (GO:0001841)3.58934113
53synapse assembly (GO:0007416)3.52101280
54cellular potassium ion homeostasis (GO:0030007)3.51394297
55cerebral cortex radially oriented cell migration (GO:0021799)3.49261205
56regulation of postsynaptic membrane potential (GO:0060078)3.49245177
57regulation of neurotransmitter secretion (GO:0046928)3.45252963
58cell migration in hindbrain (GO:0021535)3.45078446
59regulation of collateral sprouting (GO:0048670)3.44597569
60DNA double-strand break processing (GO:0000729)3.44015232
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.42208899
62long-term memory (GO:0007616)3.41088000
63somite development (GO:0061053)3.39268274
64gamma-aminobutyric acid transport (GO:0015812)3.38981307
65positive regulation of amino acid transport (GO:0051957)3.37873282
66startle response (GO:0001964)3.36415485
67auditory behavior (GO:0031223)3.35657506
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34079801
69regulation of synaptic plasticity (GO:0048167)3.28688277
70serotonin receptor signaling pathway (GO:0007210)3.28113119
71response to histamine (GO:0034776)3.27009309
72neurotransmitter transport (GO:0006836)3.25020646
73establishment of mitochondrion localization (GO:0051654)3.24508725
74behavioral response to nicotine (GO:0035095)3.22990667
75response to auditory stimulus (GO:0010996)3.20863936
76nucleobase catabolic process (GO:0046113)3.20476883
77positive regulation of dendritic spine development (GO:0060999)3.20115614
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17971329
79retinal ganglion cell axon guidance (GO:0031290)3.17300349
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16840799
81neuronal action potential propagation (GO:0019227)3.14842225
82regulation of vesicle fusion (GO:0031338)3.14222484
83regulation of dendritic spine development (GO:0060998)3.14157276
84learning (GO:0007612)3.13839739
85membrane hyperpolarization (GO:0060081)3.13160949
86establishment of synaptic vesicle localization (GO:0097480)3.12636839
87synaptic vesicle transport (GO:0048489)3.12636839
88prepulse inhibition (GO:0060134)3.11425306
89regulation of neurotransmitter transport (GO:0051588)3.10129412
90synapse organization (GO:0050808)3.09065777
91regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.07114861
92positive regulation of neurotransmitter secretion (GO:0001956)3.06900571
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06003689
94regulation of action potential (GO:0098900)3.05516386
95transmission of nerve impulse (GO:0019226)3.04528203
96positive regulation of synapse assembly (GO:0051965)3.02649271
97cerebellar granule cell differentiation (GO:0021707)3.02609604
98negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01051580
99behavioral fear response (GO:0001662)2.99085550
100behavioral defense response (GO:0002209)2.99085550
101dendritic spine organization (GO:0097061)2.97688192
102regulation of voltage-gated calcium channel activity (GO:1901385)2.97316954
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96580150
104activation of protein kinase A activity (GO:0034199)2.96395142
105protein K11-linked deubiquitination (GO:0035871)2.95872557
106membrane depolarization (GO:0051899)2.95390893
107central nervous system neuron axonogenesis (GO:0021955)2.93706033
108negative regulation of dendrite development (GO:2000171)2.92561570
109regulation of synapse organization (GO:0050807)2.90972292
110cornea development in camera-type eye (GO:0061303)2.90965095
111positive regulation of neurotransmitter transport (GO:0051590)2.89895005
112regulation of neurotransmitter levels (GO:0001505)2.89816751
113membrane depolarization during action potential (GO:0086010)2.89550558
114C4-dicarboxylate transport (GO:0015740)2.88987614
115positive regulation of synaptic transmission (GO:0050806)2.88850507
116long term synaptic depression (GO:0060292)2.88306172
117synaptic transmission (GO:0007268)2.87087689
118nonmotile primary cilium assembly (GO:0035058)2.86041655
119regulation of glutamate secretion (GO:0014048)2.84302715
120regulation of sarcomere organization (GO:0060297)2.83204145
121glycosphingolipid biosynthetic process (GO:0006688)2.82752295
122spinal cord development (GO:0021510)2.79987447
123regulation of feeding behavior (GO:0060259)2.78866798
124positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.74539080
125cerebral cortex cell migration (GO:0021795)2.72821404
126regulation of telomere maintenance (GO:0032204)2.70744864
127sympathetic nervous system development (GO:0048485)2.68884113
128epithelial cell differentiation involved in kidney development (GO:0035850)2.67806874
129protein-cofactor linkage (GO:0018065)2.67581293
130heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.62841047
131regulation of synapse assembly (GO:0051963)2.58754851
132regulation of timing of cell differentiation (GO:0048505)2.58709833
133regulation of development, heterochronic (GO:0040034)2.58669603
134protein localization to cilium (GO:0061512)2.58402654
135cardiac ventricle formation (GO:0003211)2.58267167
136detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56690964
137glial cell proliferation (GO:0014009)2.54157310
138hippocampus development (GO:0021766)2.51852315
139negative regulation of neurotransmitter transport (GO:0051589)2.50739002
140mechanosensory behavior (GO:0007638)2.50206871
141reflex (GO:0060004)2.49403955
142atrial cardiac muscle cell action potential (GO:0086014)2.49262329
143kidney morphogenesis (GO:0060993)2.48788873
144cullin deneddylation (GO:0010388)2.48738338
145microtubule depolymerization (GO:0007019)2.48215823
146negative regulation of telomere maintenance (GO:0032205)2.48028805
147negative regulation of translation, ncRNA-mediated (GO:0040033)2.47701429
148regulation of translation, ncRNA-mediated (GO:0045974)2.47701429
149negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.47701429
150negative regulation of mast cell activation (GO:0033004)2.47616376
151negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47366617
152negative regulation of astrocyte differentiation (GO:0048712)2.47306516
153regulation of respiratory system process (GO:0044065)2.46517268
154mitochondrion transport along microtubule (GO:0047497)2.46115506
155establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.46115506
156negative regulation of axon extension (GO:0030517)2.43559095
157positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.43252021
158mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.43252021
159righting reflex (GO:0060013)2.42513951
160epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42193767
161cochlea development (GO:0090102)2.40640986
162positive regulation of sodium ion transmembrane transport (GO:1902307)2.40468145
163behavioral response to ethanol (GO:0048149)2.39820764
164calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.39253085
165adaptation of signaling pathway (GO:0023058)2.38952141
166positive regulation of action potential (GO:0045760)2.35475184
167olfactory bulb development (GO:0021772)2.35031286

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.34765015
2GBX2_23144817_ChIP-Seq_PC3_Human3.96940066
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07216814
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02035781
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.99796611
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93252646
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.86344109
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.73132569
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61963228
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60643872
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60643872
12REST_21632747_ChIP-Seq_MESCs_Mouse2.59065855
13* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55248516
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.49822509
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.42422832
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.38412940
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35969488
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35950445
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35527572
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.30005828
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.27281925
22DROSHA_22980978_ChIP-Seq_HELA_Human2.24990543
23EWS_26573619_Chip-Seq_HEK293_Human2.21909351
24AR_21572438_ChIP-Seq_LNCaP_Human2.21233550
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.20611144
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19356852
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19299884
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15512862
29RARB_27405468_Chip-Seq_BRAIN_Mouse2.07744462
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.04522266
31REST_18959480_ChIP-ChIP_MESCs_Mouse2.00220099
32TAF15_26573619_Chip-Seq_HEK293_Human1.96906694
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94303500
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88391041
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87298454
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85371347
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75366658
38SMAD4_21799915_ChIP-Seq_A2780_Human1.71018498
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.66967641
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63789680
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63517061
42P300_19829295_ChIP-Seq_ESCs_Human1.63355323
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63303611
44* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62881081
45ZNF274_21170338_ChIP-Seq_K562_Hela1.58018293
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57344566
47* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56231425
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.55537637
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51834820
50* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49874165
51FUS_26573619_Chip-Seq_HEK293_Human1.48854189
52RNF2_27304074_Chip-Seq_NSC_Mouse1.48062643
53EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47415736
54* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43884645
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.43537912
56IGF1R_20145208_ChIP-Seq_DFB_Human1.42513249
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41024293
58* SOX2_21211035_ChIP-Seq_LN229_Gbm1.39508202
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.39006763
60* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38633827
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38389135
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.37285796
63AR_25329375_ChIP-Seq_VCAP_Human1.37109156
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35181815
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.34714952
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32522533
67BCAT_22108803_ChIP-Seq_LS180_Human1.31133204
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29796730
69* SMAD_19615063_ChIP-ChIP_OVARY_Human1.27508750
70STAT3_23295773_ChIP-Seq_U87_Human1.27378029
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25172741
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25003036
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.23921656
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23831551
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23394359
76* AR_19668381_ChIP-Seq_PC3_Human1.22960416
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22589893
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21709080
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20565226
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20475397
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20475397
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19940811
83* TCF4_22108803_ChIP-Seq_LS180_Human1.17993459
84TCF4_23295773_ChIP-Seq_U87_Human1.15438521
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15267522
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14885082
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.14596273
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14537170
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14496727
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.14203311
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13853229
92ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12971400
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.12280965
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12152732
95ER_23166858_ChIP-Seq_MCF-7_Human1.11666760
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11008185
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10330042
98* FLI1_21867929_ChIP-Seq_TH2_Mouse1.09684280
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09663110
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07991323
101P53_22387025_ChIP-Seq_ESCs_Mouse1.07905441
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07528508
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05425780
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05328650
105AHR_22903824_ChIP-Seq_MCF-7_Human1.05148883
106NFE2_27457419_Chip-Seq_LIVER_Mouse1.04517957
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.04339000
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04042522
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03189756
110* PRDM14_20953172_ChIP-Seq_ESCs_Human1.03000276
111RUNX2_22187159_ChIP-Seq_PCA_Human1.02847668
112JUN_21703547_ChIP-Seq_K562_Human1.02686094
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02622935
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02165472
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02025585
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01342954
117SOX2_19829295_ChIP-Seq_ESCs_Human1.01196580
118NANOG_19829295_ChIP-Seq_ESCs_Human1.01196580
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.01095711
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.01057300
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00278459
122TP53_22573176_ChIP-Seq_HFKS_Human0.99514489
123* KDM2B_26808549_Chip-Seq_REH_Human0.99144747
124* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98106492
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.97785019
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.96473045
127TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94373907
128SOX9_26525672_Chip-Seq_HEART_Mouse0.93371762
129VDR_22108803_ChIP-Seq_LS180_Human0.91617826
130CBP_20019798_ChIP-Seq_JUKART_Human0.91249747
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.91249747
132* TP53_18474530_ChIP-ChIP_U2OS_Human0.90017565
133TP53_20018659_ChIP-ChIP_R1E_Mouse0.89717494

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.75684899
2MP0003880_abnormal_central_pattern4.70611297
3MP0003635_abnormal_synaptic_transmissio3.93439574
4MP0004270_analgesia3.77411362
5MP0002063_abnormal_learning/memory/cond3.31901660
6MP0001968_abnormal_touch/_nociception3.13516899
7MP0005423_abnormal_somatic_nervous3.08742573
8MP0009745_abnormal_behavioral_response3.08738558
9MP0002734_abnormal_mechanical_nocicepti2.81077115
10MP0002064_seizures2.80475340
11MP0002572_abnormal_emotion/affect_behav2.67577541
12MP0009046_muscle_twitch2.67131086
13MP0001486_abnormal_startle_reflex2.66435048
14MP0002736_abnormal_nociception_after2.58008944
15MP0000778_abnormal_nervous_system2.43375998
16MP0002735_abnormal_chemical_nociception2.19900131
17MP0002272_abnormal_nervous_system2.18910771
18MP0001984_abnormal_olfaction2.12340107
19MP0002184_abnormal_innervation2.10753622
20MP0009780_abnormal_chondrocyte_physiolo2.02159801
21MP0008877_abnormal_DNA_methylation1.97785569
22MP0005551_abnormal_eye_electrophysiolog1.97411629
23MP0002067_abnormal_sensory_capabilities1.95078750
24MP0002733_abnormal_thermal_nociception1.90483387
25MP0001440_abnormal_grooming_behavior1.87855239
26MP0001970_abnormal_pain_threshold1.86565113
27MP0002557_abnormal_social/conspecific_i1.81026968
28MP0001188_hyperpigmentation1.80320495
29MP0004811_abnormal_neuron_physiology1.77514690
30MP0004924_abnormal_behavior1.71769068
31MP0005386_behavior/neurological_phenoty1.71769068
32MP0002822_catalepsy1.70531648
33MP0006276_abnormal_autonomic_nervous1.70426661
34MP0001501_abnormal_sleep_pattern1.66034036
35MP0000955_abnormal_spinal_cord1.62665099
36MP0008569_lethality_at_weaning1.59069073
37MP0002882_abnormal_neuron_morphology1.56103247
38MP0001502_abnormal_circadian_rhythm1.54274336
39MP0004858_abnormal_nervous_system1.53723591
40MP0002909_abnormal_adrenal_gland1.52569510
41MP0004133_heterotaxia1.50437233
42MP0003879_abnormal_hair_cell1.50326257
43MP0003890_abnormal_embryonic-extraembry1.49959380
44MP0000569_abnormal_digit_pigmentation1.48997424
45MP0000516_abnormal_urinary_system1.48986266
46MP0005367_renal/urinary_system_phenotyp1.48986266
47MP0003283_abnormal_digestive_organ1.48785311
48MP0003122_maternal_imprinting1.46657195
49MP0000631_abnormal_neuroendocrine_gland1.39862381
50MP0004885_abnormal_endolymph1.39686893
51MP0003329_amyloid_beta_deposits1.39074989
52MP0001529_abnormal_vocalization1.36284445
53MP0002066_abnormal_motor_capabilities/c1.34352671
54MP0005646_abnormal_pituitary_gland1.33398813
55MP0002090_abnormal_vision1.30692792
56MP0002152_abnormal_brain_morphology1.28278071
57MP0000049_abnormal_middle_ear1.26165341
58MP0003787_abnormal_imprinting1.25780101
59MP0004043_abnormal_pH_regulation1.22359279
60MP0005499_abnormal_olfactory_system1.21621512
61MP0005394_taste/olfaction_phenotype1.21621512
62MP0003937_abnormal_limbs/digits/tail_de1.19962566
63MP0003567_abnormal_fetal_cardiomyocyte1.15013078
64MP0006072_abnormal_retinal_apoptosis1.12456206
65MP0000647_abnormal_sebaceous_gland1.12031367
66MP0006292_abnormal_olfactory_placode1.11134123
67MP0004147_increased_porphyrin_level1.09707772
68MP0005645_abnormal_hypothalamus_physiol1.09480220
69MP0008058_abnormal_DNA_repair1.09102683
70MP0008995_early_reproductive_senescence1.08889547
71MP0003718_maternal_effect1.06943433
72MP0002752_abnormal_somatic_nervous1.04362349
73MP0003633_abnormal_nervous_system1.03853126
74MP0002938_white_spotting1.01809842
75MP0004742_abnormal_vestibular_system0.99597840
76MP0002069_abnormal_eating/drinking_beha0.98822887
77MP0001905_abnormal_dopamine_level0.97403442
78MP0004142_abnormal_muscle_tone0.97345261
79MP0003136_yellow_coat_color0.96194811
80MP0002233_abnormal_nose_morphology0.96015946
81MP0004215_abnormal_myocardial_fiber0.95661795
82MP0000566_synostosis0.93929812
83MP0002229_neurodegeneration0.93418775
84MP0008789_abnormal_olfactory_epithelium0.92711872
85MP0005248_abnormal_Harderian_gland0.92667104
86MP0004145_abnormal_muscle_electrophysio0.91479476
87MP0003137_abnormal_impulse_conducting0.91150350
88MP0005253_abnormal_eye_physiology0.90220233
89MP0003755_abnormal_palate_morphology0.89643570
90MP0004233_abnormal_muscle_weight0.88761772
91MP0003631_nervous_system_phenotype0.87514121
92MP0003195_calcinosis0.86827454
93MP0003861_abnormal_nervous_system0.86612515
94MP0005195_abnormal_posterior_eye0.86473008
95MP0003634_abnormal_glial_cell0.84647847
96MP0004085_abnormal_heartbeat0.84491446
97MP0001299_abnormal_eye_distance/0.81844891
98MP0001963_abnormal_hearing_physiology0.81820670
99MP0000427_abnormal_hair_cycle0.80335878
100MP0005171_absent_coat_pigmentation0.80136338
101MP0005187_abnormal_penis_morphology0.80045452
102MP0005084_abnormal_gallbladder_morpholo0.79769970
103MP0010386_abnormal_urinary_bladder0.79444435
104MP0001485_abnormal_pinna_reflex0.79428618
105MP0000751_myopathy0.76179198
106MP0002234_abnormal_pharynx_morphology0.75949092
107MP0001177_atelectasis0.75131894
108MP0001293_anophthalmia0.73738409
109MP0003121_genomic_imprinting0.73406232
110MP0002751_abnormal_autonomic_nervous0.72218988
111MP0002876_abnormal_thyroid_physiology0.67910435
112MP0005409_darkened_coat_color0.67666077
113MP0000026_abnormal_inner_ear0.66558250
114MP0000534_abnormal_ureter_morphology0.64466360
115MP0004484_altered_response_of0.63459211
116MP0001943_abnormal_respiration0.62723841
117MP0002102_abnormal_ear_morphology0.62399383
118MP0008872_abnormal_physiological_respon0.60733781
119MP0002081_perinatal_lethality0.60472965
120MP0002082_postnatal_lethality0.60338003
121MP0010770_preweaning_lethality0.60338003
122MP0010769_abnormal_survival0.59789177
123MP0002638_abnormal_pupillary_reflex0.57172922
124MP0003385_abnormal_body_wall0.56689787
125MP0010768_mortality/aging0.56139472
126MP0003119_abnormal_digestive_system0.55934510

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.31231929
2Myokymia (HP:0002411)5.51142456
3Epileptic encephalopathy (HP:0200134)5.39130517
4Focal seizures (HP:0007359)4.88299146
5Visual hallucinations (HP:0002367)4.75001348
6Abnormality of the labia minora (HP:0012880)4.57108327
7Febrile seizures (HP:0002373)4.30559533
8Progressive cerebellar ataxia (HP:0002073)4.14155363
9Absence seizures (HP:0002121)3.97299735
10Atonic seizures (HP:0010819)3.87083844
11Mutism (HP:0002300)3.77619269
12Broad-based gait (HP:0002136)3.68931861
13Dialeptic seizures (HP:0011146)3.52629136
14Hyperventilation (HP:0002883)3.43815820
15Ankle clonus (HP:0011448)3.41203587
16Excessive salivation (HP:0003781)3.40387206
17Drooling (HP:0002307)3.40387206
18Generalized tonic-clonic seizures (HP:0002069)3.26620126
19Congenital stationary night blindness (HP:0007642)3.23395471
20Poor eye contact (HP:0000817)3.03532153
21Supranuclear gaze palsy (HP:0000605)2.99283998
22Action tremor (HP:0002345)2.98192838
23Depression (HP:0000716)2.89766043
24Genetic anticipation (HP:0003743)2.88642531
25Dysdiadochokinesis (HP:0002075)2.88618423
26True hermaphroditism (HP:0010459)2.88486506
27Epileptiform EEG discharges (HP:0011182)2.87953346
28Pancreatic cysts (HP:0001737)2.84332817
29Gaze-evoked nystagmus (HP:0000640)2.84242209
30Pancreatic fibrosis (HP:0100732)2.77444802
31Septo-optic dysplasia (HP:0100842)2.77299276
32EEG with generalized epileptiform discharges (HP:0011198)2.76395939
33Amblyopia (HP:0000646)2.74291803
34Urinary bladder sphincter dysfunction (HP:0002839)2.73893810
35Impaired vibration sensation in the lower limbs (HP:0002166)2.71855510
36Amyotrophic lateral sclerosis (HP:0007354)2.69291114
37Impaired social interactions (HP:0000735)2.68529640
38Abnormal social behavior (HP:0012433)2.68529640
39Polyphagia (HP:0002591)2.64622948
40Limb dystonia (HP:0002451)2.59009037
41Molar tooth sign on MRI (HP:0002419)2.58784041
42Abnormality of midbrain morphology (HP:0002418)2.58784041
43Colon cancer (HP:0003003)2.58514491
44Aplasia/Hypoplasia of the sternum (HP:0006714)2.55151501
45Truncal ataxia (HP:0002078)2.54503984
46Gait imbalance (HP:0002141)2.52633114
47Abnormality of the corticospinal tract (HP:0002492)2.52499503
48Hypsarrhythmia (HP:0002521)2.51375795
49Abnormal eating behavior (HP:0100738)2.50742271
50Akinesia (HP:0002304)2.47863305
51Torticollis (HP:0000473)2.46968980
52Hemiparesis (HP:0001269)2.46612452
53Dysmetria (HP:0001310)2.46167673
54Absent speech (HP:0001344)2.45161045
55Astrocytoma (HP:0009592)2.45151952
56Abnormality of the astrocytes (HP:0100707)2.45151952
57Anxiety (HP:0000739)2.45031861
58Medial flaring of the eyebrow (HP:0010747)2.44708586
59Nephronophthisis (HP:0000090)2.43088811
60Urinary urgency (HP:0000012)2.41788600
61Pendular nystagmus (HP:0012043)2.39463514
62Abnormality of the 1st metacarpal (HP:0010009)2.38861371
63Glioma (HP:0009733)2.36751253
64Central scotoma (HP:0000603)2.35294740
65Cerebral inclusion bodies (HP:0100314)2.34775733
66Postural instability (HP:0002172)2.34669726
67Papilledema (HP:0001085)2.33696629
68Spastic gait (HP:0002064)2.33444973
69Abnormal hair whorl (HP:0010721)2.33384222
70Stereotypic behavior (HP:0000733)2.33144240
71Fetal akinesia sequence (HP:0001989)2.32000362
72Neurofibrillary tangles (HP:0002185)2.31848301
73Termporal pattern (HP:0011008)2.28497760
74Insidious onset (HP:0003587)2.28497760
75Abnormality of the lower motor neuron (HP:0002366)2.28162332
76Short phalanx of the thumb (HP:0009660)2.27732042
77Abnormality of macular pigmentation (HP:0008002)2.26379535
78Inability to walk (HP:0002540)2.25733008
79Megalencephaly (HP:0001355)2.25677870
80Genital tract atresia (HP:0001827)2.25163502
81Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.24714525
82Short 1st metacarpal (HP:0010034)2.24714525
83Chronic hepatic failure (HP:0100626)2.24000665
84Inappropriate behavior (HP:0000719)2.23828239
85Hyperglycinemia (HP:0002154)2.23180621
86Abnormality of salivation (HP:0100755)2.22050898
87Abolished electroretinogram (ERG) (HP:0000550)2.20920772
88Focal dystonia (HP:0004373)2.20010500
89Methylmalonic acidemia (HP:0002912)2.19945000
90Progressive inability to walk (HP:0002505)2.19680953
91Vaginal atresia (HP:0000148)2.16484934
92Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14727235
93Protruding tongue (HP:0010808)2.13633552
94Blue irides (HP:0000635)2.13170376
95Medulloblastoma (HP:0002885)2.12244406
96Neoplasm of the oral cavity (HP:0100649)2.12108080
97Scanning speech (HP:0002168)2.12034482
98Bradykinesia (HP:0002067)2.09639472
99Scrotal hypoplasia (HP:0000046)2.09276730
100Agitation (HP:0000713)2.08785685
101Nephrogenic diabetes insipidus (HP:0009806)2.08358363
102Lissencephaly (HP:0001339)2.08344801
103Diplopia (HP:0000651)2.07749093
104Abnormality of binocular vision (HP:0011514)2.07749093
105Aplasia/Hypoplasia of the tibia (HP:0005772)2.07549238
106Tubulointerstitial nephritis (HP:0001970)2.06820731
107Craniofacial dystonia (HP:0012179)2.02647524
108Long clavicles (HP:0000890)2.00034669
109Impaired smooth pursuit (HP:0007772)1.99142954
110Postaxial hand polydactyly (HP:0001162)1.99094083
111Abnormality of the renal medulla (HP:0100957)1.99080485
112Ependymoma (HP:0002888)1.97819337
113Volvulus (HP:0002580)1.97555086
114Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.96883805
115Hypoplasia of the brainstem (HP:0002365)1.93877251
116Aplasia/Hypoplasia of the brainstem (HP:0007362)1.93877251
117Lower limb muscle weakness (HP:0007340)1.93181286
118Absent eyebrow (HP:0002223)1.93165826
119Labial hypoplasia (HP:0000066)1.92717696
120Narrow forehead (HP:0000341)1.92686296
121Renal hypoplasia (HP:0000089)1.90544260
122Optic nerve hypoplasia (HP:0000609)1.90350191
123Cupped ear (HP:0000378)1.89300007
124Absent septum pellucidum (HP:0001331)1.88884480
125Pachygyria (HP:0001302)1.86161903
126Anencephaly (HP:0002323)1.86154342
127Incomplete penetrance (HP:0003829)1.85887558
128Hepatoblastoma (HP:0002884)1.85703621
129Shoulder girdle muscle weakness (HP:0003547)1.84335293
130Specific learning disability (HP:0001328)1.84097682
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.83006124
132Generalized myoclonic seizures (HP:0002123)1.81714773
133Aqueductal stenosis (HP:0002410)1.81021478
134Narrow nasal bridge (HP:0000446)1.80621465
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.80547591
136Absent/shortened dynein arms (HP:0200106)1.80547591
137Obstructive sleep apnea (HP:0002870)1.79921345
138Widely spaced teeth (HP:0000687)1.78354877
139Fair hair (HP:0002286)1.78053715
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77212565
141Abnormality of ocular smooth pursuit (HP:0000617)1.76978037
142Retinal dysplasia (HP:0007973)1.76646902
143Cutaneous finger syndactyly (HP:0010554)1.75842366
144Impaired vibratory sensation (HP:0002495)1.75576963
145Supernumerary spleens (HP:0009799)1.75558566
146Neoplasm of the adrenal cortex (HP:0100641)1.75513493
147Clonus (HP:0002169)1.75201060
148Keratoconus (HP:0000563)1.74900228
149Increased corneal curvature (HP:0100692)1.74900228
150Pointed chin (HP:0000307)1.74839659
151Abnormality of the pubic bones (HP:0003172)1.74294706
152Hypoplastic female external genitalia (HP:0012815)1.74063131
153Morphological abnormality of the pyramidal tract (HP:0002062)1.74027235
154Short tibia (HP:0005736)1.73858092
155Congenital primary aphakia (HP:0007707)1.72615453
156Patellar aplasia (HP:0006443)1.72446689
157Micropenis (HP:0000054)1.72073139
158Intellectual disability, profound (HP:0002187)1.72017086
159Meckel diverticulum (HP:0002245)1.71034194
160Sclerocornea (HP:0000647)1.69408720
161Oligodactyly (hands) (HP:0001180)1.69327618
162Short foot (HP:0001773)1.68721351
163Hypothermia (HP:0002045)1.68524869

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.70352276
2EPHA43.73740240
3NTRK33.43833762
4MAP4K23.41380570
5MAP3K93.06423883
6FRK3.04163461
7MAP3K42.99546158
8CASK2.88056607
9MAP2K72.74927751
10PINK12.73210373
11MINK12.68976777
12TRIM282.48489890
13DAPK22.46578693
14PAK62.38026704
15BCKDK2.35163523
16NTRK22.20403964
17MAPK131.97239471
18KSR11.89423527
19PHKG21.75636013
20PHKG11.75636013
21MKNK21.74128375
22NUAK11.71468797
23MAP2K41.68047635
24SIK21.66125979
25MAP3K121.64750023
26TNIK1.63282383
27PLK21.62777961
28PRPF4B1.62646210
29BMPR1B1.58971127
30KSR21.55167670
31DAPK11.48097547
32CDK51.42838243
33CDK191.41258852
34ERBB31.35671193
35PRKD31.33652095
36CSNK1G11.33638690
37LATS21.32705136
38CAMKK11.31036830
39ZAK1.29428297
40CCNB11.28677492
41AKT31.21194345
42RIPK41.18414802
43PRKCG1.17328359
44DYRK21.15621488
45INSRR1.14917205
46PNCK1.14468492
47MKNK11.14155227
48GRK51.14050852
49DYRK1A1.12444400
50NTRK11.10028689
51ADRBK21.02449101
52CSNK1G20.94894127
53ACVR1B0.94683023
54TAOK10.93391863
55FES0.92677734
56PLK30.92625262
57CDK140.91857949
58TSSK60.91604659
59CDK180.91105991
60CAMK2A0.90407568
61VRK10.88884009
62CDK150.88442952
63GRK10.84499242
64TYRO30.83907512
65MARK20.82553495
66MAP3K60.81957420
67CAMKK20.81571152
68STK38L0.80636555
69SGK2230.79354797
70SGK4940.79354797
71PAK30.79212082
72NEK10.77721521
73CDK11A0.77135375
74MAP3K20.75410639
75SGK20.74684949
76UHMK10.74377696
77STK110.73858168
78EPHA30.71801783
79PRKCZ0.70078439
80TAOK30.69860774
81STK380.69216802
82PLK40.68211782
83RET0.66633549
84SGK10.65751300
85PKN10.65354868
86EIF2AK30.65324652
87PRKCE0.65143264
88SRPK10.63679676
89OXSR10.59951615
90CAMK2B0.59055072
91CAMK10.57599934
92SIK30.56800167
93CAMK1D0.56263669
94BUB10.55719479
95NME10.55451154
96MAPK120.55382347
97WNK30.54388463
98RAF10.52931576
99ADRBK10.50351819
100CSNK1D0.48969640
101CAMK1G0.48321046
102BMPR20.47699369
103SGK30.47256604
104CSNK1A10.47111197
105TAOK20.45517279
106RPS6KA30.45459015
107TGFBR10.45042614
108FYN0.44622362
109CSNK1G30.43430249
110CAMK40.42994506
111CDK30.42786680
112BRSK20.42088325
113EPHB20.41125974
114PTK2B0.40834635
115MAPK100.40443999
116PRKCH0.39590822
117CSNK1A1L0.38786399
118PRKG10.38201801
119RPS6KA40.37902680
120PRKACA0.37417166
121MAPKAPK50.36958756
122FGFR20.35802599
123DYRK30.35328967
124RPS6KA20.35087786
125FLT30.34927851
126PRKCB0.33166207
127SCYL20.33078129
128MAPK90.31424171
129CAMK2D0.31317418
130PRKDC0.29691903
131BCR0.29152951
132MAP2K10.29054762
133CSNK1E0.29022875
134MAPK150.28658044
135MAPK80.28633196
136PLK10.27902854
137ATR0.27657096
138FER0.27529403
139PRKACB0.27419428
140GSK3B0.27348466
141ATM0.27036745
142YES10.26605904
143RPS6KA50.26032291
144LMTK20.25442095
145PDK10.25127207

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26883593
2Synaptic vesicle cycle_Homo sapiens_hsa047213.44210204
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94964574
4GABAergic synapse_Homo sapiens_hsa047272.93940524
5Morphine addiction_Homo sapiens_hsa050322.80827947
6Circadian entrainment_Homo sapiens_hsa047132.75958666
7Olfactory transduction_Homo sapiens_hsa047402.57193558
8Glutamatergic synapse_Homo sapiens_hsa047242.52237842
9Long-term potentiation_Homo sapiens_hsa047202.36775998
10Dopaminergic synapse_Homo sapiens_hsa047282.18518654
11Amphetamine addiction_Homo sapiens_hsa050312.14975845
12Cholinergic synapse_Homo sapiens_hsa047252.02039343
13Propanoate metabolism_Homo sapiens_hsa006401.95482796
14Salivary secretion_Homo sapiens_hsa049701.94893653
15Butanoate metabolism_Homo sapiens_hsa006501.91155275
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.91130608
17Insulin secretion_Homo sapiens_hsa049111.86610781
18Renin secretion_Homo sapiens_hsa049241.79397055
19Serotonergic synapse_Homo sapiens_hsa047261.77396052
20Fanconi anemia pathway_Homo sapiens_hsa034601.73616477
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.71829252
22Taste transduction_Homo sapiens_hsa047421.69408080
23Oxytocin signaling pathway_Homo sapiens_hsa049211.67633597
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64920455
25Axon guidance_Homo sapiens_hsa043601.64415041
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.63609529
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59347398
28Long-term depression_Homo sapiens_hsa047301.56519156
29Collecting duct acid secretion_Homo sapiens_hsa049661.53507485
30Gastric acid secretion_Homo sapiens_hsa049711.49165400
31Steroid biosynthesis_Homo sapiens_hsa001001.47846342
32Calcium signaling pathway_Homo sapiens_hsa040201.46889650
33Cocaine addiction_Homo sapiens_hsa050301.44170764
34Non-homologous end-joining_Homo sapiens_hsa034501.41194111
35Gap junction_Homo sapiens_hsa045401.38118142
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34162896
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32995900
38Type II diabetes mellitus_Homo sapiens_hsa049301.27940036
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27760064
40Ether lipid metabolism_Homo sapiens_hsa005651.26488477
41Protein export_Homo sapiens_hsa030601.25302574
42Basal transcription factors_Homo sapiens_hsa030221.24194484
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23145290
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22398753
45GnRH signaling pathway_Homo sapiens_hsa049121.20222635
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19142168
47Phototransduction_Homo sapiens_hsa047441.19029423
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18925530
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17796238
50Linoleic acid metabolism_Homo sapiens_hsa005911.16907469
51cAMP signaling pathway_Homo sapiens_hsa040241.15933434
52Glioma_Homo sapiens_hsa052141.14432937
53ErbB signaling pathway_Homo sapiens_hsa040121.12862875
54Estrogen signaling pathway_Homo sapiens_hsa049151.06664358
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05288060
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05062974
57Oxidative phosphorylation_Homo sapiens_hsa001901.02685898
58Melanogenesis_Homo sapiens_hsa049161.01466574
59RNA degradation_Homo sapiens_hsa030180.96404213
60Cardiac muscle contraction_Homo sapiens_hsa042600.96087813
61Parkinsons disease_Homo sapiens_hsa050120.96031281
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92785168
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91573566
64Peroxisome_Homo sapiens_hsa041460.91213027
65Nitrogen metabolism_Homo sapiens_hsa009100.91018432
66Sulfur relay system_Homo sapiens_hsa041220.90868858
67Vibrio cholerae infection_Homo sapiens_hsa051100.90391471
68Homologous recombination_Homo sapiens_hsa034400.90223360
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85373774
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.83726854
71Selenocompound metabolism_Homo sapiens_hsa004500.83655698
72RNA polymerase_Homo sapiens_hsa030200.82815329
73Endometrial cancer_Homo sapiens_hsa052130.80041674
74Tryptophan metabolism_Homo sapiens_hsa003800.79278868
75Basal cell carcinoma_Homo sapiens_hsa052170.79268054
76Oocyte meiosis_Homo sapiens_hsa041140.78921294
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78311799
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77850694
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77036008
80Dilated cardiomyopathy_Homo sapiens_hsa054140.76224617
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75859712
82Renal cell carcinoma_Homo sapiens_hsa052110.74972137
83Colorectal cancer_Homo sapiens_hsa052100.74526099
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73756875
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.73015057
86MAPK signaling pathway_Homo sapiens_hsa040100.71902629
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71520237
88Alcoholism_Homo sapiens_hsa050340.69808372
89Choline metabolism in cancer_Homo sapiens_hsa052310.69485013
90* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69386991
91Regulation of autophagy_Homo sapiens_hsa041400.69164551
92mTOR signaling pathway_Homo sapiens_hsa041500.68975408
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67639513
94Caffeine metabolism_Homo sapiens_hsa002320.67496065
95Circadian rhythm_Homo sapiens_hsa047100.67423867
96Wnt signaling pathway_Homo sapiens_hsa043100.66629032
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65390602
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65217255
99Ras signaling pathway_Homo sapiens_hsa040140.64910525
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63095521
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.62258406
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.61902303
103Dorso-ventral axis formation_Homo sapiens_hsa043200.60426297
104VEGF signaling pathway_Homo sapiens_hsa043700.59771837
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58208998
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.57729139
107Rap1 signaling pathway_Homo sapiens_hsa040150.57002369
108Retinol metabolism_Homo sapiens_hsa008300.55491661
109Pancreatic secretion_Homo sapiens_hsa049720.55417531
110Ovarian steroidogenesis_Homo sapiens_hsa049130.55070300
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.54807569
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.54630928
113Purine metabolism_Homo sapiens_hsa002300.54530190
114Fatty acid metabolism_Homo sapiens_hsa012120.54233427
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53112902
116Huntingtons disease_Homo sapiens_hsa050160.52316073
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52193122
118Thyroid hormone synthesis_Homo sapiens_hsa049180.51183124
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49920938
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.49872762
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49626898
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49622565
123Fatty acid biosynthesis_Homo sapiens_hsa000610.46876740
124Glucagon signaling pathway_Homo sapiens_hsa049220.45430028
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45196961
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45176498
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45052906
128Non-small cell lung cancer_Homo sapiens_hsa052230.44617849
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44203211
130beta-Alanine metabolism_Homo sapiens_hsa004100.44200698
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43769868
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42611764
133Insulin signaling pathway_Homo sapiens_hsa049100.41687448
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41137746
135Melanoma_Homo sapiens_hsa052180.39818414
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.39789980
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39515290
138Endocytosis_Homo sapiens_hsa041440.39478173
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37821829
140Hedgehog signaling pathway_Homo sapiens_hsa043400.36752372
141Mismatch repair_Homo sapiens_hsa034300.36356777
142Folate biosynthesis_Homo sapiens_hsa007900.36322293
143SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35632210
144Chemical carcinogenesis_Homo sapiens_hsa052040.35345592
145* Metabolic pathways_Homo sapiens_hsa011000.34344589
146Prion diseases_Homo sapiens_hsa050200.33328176
147Chemokine signaling pathway_Homo sapiens_hsa040620.30685832
148Inositol phosphate metabolism_Homo sapiens_hsa005620.30405316
149Hippo signaling pathway_Homo sapiens_hsa043900.29451110
150Alzheimers disease_Homo sapiens_hsa050100.28928591
151Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27725702
152African trypanosomiasis_Homo sapiens_hsa051430.26889220

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