ST6GALNAC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.33316953
2cell wall macromolecule catabolic process (GO:0016998)8.74067379
3cell wall macromolecule metabolic process (GO:0044036)8.74067379
4plasma membrane fusion (GO:0045026)8.28500167
5cilium or flagellum-dependent cell motility (GO:0001539)8.04439365
6multicellular organism reproduction (GO:0032504)7.99016973
7sperm-egg recognition (GO:0035036)7.97101056
8organic cation transport (GO:0015695)7.67803402
9binding of sperm to zona pellucida (GO:0007339)7.17143365
10epithelial cilium movement (GO:0003351)7.14585191
11cell-cell recognition (GO:0009988)7.10919094
12axonemal dynein complex assembly (GO:0070286)7.05651453
13acrosome reaction (GO:0007340)7.05105525
14acrosome assembly (GO:0001675)6.84341681
15reproduction (GO:0000003)6.82455909
16motile cilium assembly (GO:0044458)6.68111695
17spermatid development (GO:0007286)6.64805521
18regulation of cilium movement (GO:0003352)6.29923806
19melanin biosynthetic process (GO:0042438)6.11979941
20cilium movement (GO:0003341)6.02241766
21sperm capacitation (GO:0048240)5.78951710
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.66286879
23melanin metabolic process (GO:0006582)5.53811359
24single fertilization (GO:0007338)5.49678270
25drug transmembrane transport (GO:0006855)5.13155406
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.84434369
27secondary metabolite biosynthetic process (GO:0044550)4.77677156
28phosphatidylethanolamine biosynthetic process (GO:0006646)4.58710537
29quaternary ammonium group transport (GO:0015697)4.52889010
30carnitine transport (GO:0015879)4.52683257
31amino-acid betaine transport (GO:0015838)4.52683257
32male meiosis (GO:0007140)4.49475015
33piRNA metabolic process (GO:0034587)4.46062373
34drug transport (GO:0015893)4.44037654
35urate metabolic process (GO:0046415)4.43639156
36fertilization (GO:0009566)4.42591008
37desmosome organization (GO:0002934)4.39984454
38axoneme assembly (GO:0035082)4.37880180
39synaptonemal complex organization (GO:0070193)4.33662936
40synaptonemal complex assembly (GO:0007130)4.27384563
41phosphatidylethanolamine metabolic process (GO:0046337)4.18513196
42regulation of interleukin-13 production (GO:0032656)4.16984347
43spermatogenesis (GO:0007283)4.10433971
44male gamete generation (GO:0048232)4.09477210
45hemidesmosome assembly (GO:0031581)4.02105607
46phosphate ion transport (GO:0006817)3.96517337
47regulation of interleukin-5 production (GO:0032674)3.91837074
48interferon-gamma secretion (GO:0072643)3.87113995
49negative regulation of inclusion body assembly (GO:0090084)3.83584203
50alditol metabolic process (GO:0019400)3.82118458
51gamete generation (GO:0007276)3.74321237
52microtubule depolymerization (GO:0007019)3.73283617
53germ cell development (GO:0007281)3.65700608
54glycerol ether metabolic process (GO:0006662)3.64716802
55cellular process involved in reproduction in multicellular organism (GO:0022412)3.62717728
56regulation of T-helper 2 cell differentiation (GO:0045628)3.61542649
57peptide catabolic process (GO:0043171)3.61175429
58phosphate ion homeostasis (GO:0055062)3.58119755
59trivalent inorganic anion homeostasis (GO:0072506)3.58119755
60regulation of microtubule-based movement (GO:0060632)3.55908995
61carnitine transmembrane transport (GO:1902603)3.55416543
62aminoglycoside antibiotic metabolic process (GO:0030647)3.51587182
63surfactant homeostasis (GO:0043129)3.49812669
64phosphate ion transmembrane transport (GO:0035435)3.43516126
65male meiosis I (GO:0007141)3.41381044
66renal absorption (GO:0070293)3.41042247
67chromosome condensation (GO:0030261)3.33552796
68ether metabolic process (GO:0018904)3.30615429
69glycerol metabolic process (GO:0006071)3.30611230
70fructose metabolic process (GO:0006000)3.30551387
71glomerular epithelial cell development (GO:0072310)3.29716760
72homocysteine metabolic process (GO:0050667)3.27819595
73centriole assembly (GO:0098534)3.26772035
74excretion (GO:0007588)3.26177220
75primary alcohol catabolic process (GO:0034310)3.24927331
76negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.22813327
77macrophage activation involved in immune response (GO:0002281)3.16996699
78positive regulation by symbiont of host defense response (GO:0052509)3.16797341
79modulation by symbiont of host defense response (GO:0052031)3.16797341
80modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.16797341
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.16797341
82positive regulation by organism of defense response of other organism involved in symbiotic interact3.16797341
83modulation by symbiont of host immune response (GO:0052553)3.16797341
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16592759
85seminiferous tubule development (GO:0072520)3.15690473
86epithelial cell differentiation involved in prostate gland development (GO:0060742)3.14910094
87regulation of inclusion body assembly (GO:0090083)3.14838432
88DNA packaging (GO:0006323)3.14491678
89polyol transport (GO:0015791)3.14411453
90sulfate transmembrane transport (GO:1902358)3.14052619
91ventricular system development (GO:0021591)3.12490639
92pyrimidine-containing compound transmembrane transport (GO:0072531)3.12276219
93regulation of water loss via skin (GO:0033561)3.10540487
94left/right pattern formation (GO:0060972)3.09735666
95polyol catabolic process (GO:0046174)3.07692536
96lysine metabolic process (GO:0006553)3.07449923
97lysine catabolic process (GO:0006554)3.07449923
98microtubule polymerization or depolymerization (GO:0031109)3.07188919
99glutathione derivative metabolic process (GO:1901685)3.06955061
100glutathione derivative biosynthetic process (GO:1901687)3.06955061
101multicellular organismal reproductive process (GO:0048609)3.05794376
102establishment of skin barrier (GO:0061436)3.04878482
103proline metabolic process (GO:0006560)3.00076980
104response to mercury ion (GO:0046689)2.99635909
105detection of other organism (GO:0098543)2.99607132
106positive regulation of tolerance induction (GO:0002645)2.98894794
107chemical homeostasis within a tissue (GO:0048875)2.97967957
108tolerance induction (GO:0002507)2.96271168
109left/right axis specification (GO:0070986)2.95603758
110valine metabolic process (GO:0006573)2.93901395
111antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.92011208
112microtubule bundle formation (GO:0001578)2.90446674
113cell recognition (GO:0008037)2.87965079
114ethanol metabolic process (GO:0006067)2.87546300
115protein targeting to Golgi (GO:0000042)2.85943927
116detection of bacterium (GO:0016045)2.85917483
117transepithelial transport (GO:0070633)2.85630851
118negative regulation of immunoglobulin mediated immune response (GO:0002890)2.85510595
119negative regulation of B cell mediated immunity (GO:0002713)2.85510595
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.85104144
121antigen processing and presentation of endogenous antigen (GO:0019883)2.82905219
122calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.82114635
123cysteine metabolic process (GO:0006534)2.80733116
124DNA methylation involved in gamete generation (GO:0043046)2.79549827
125response to xenobiotic stimulus (GO:0009410)2.78314208
126fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77284688
127negative regulation of humoral immune response (GO:0002921)2.77116973
128multicellular organismal water homeostasis (GO:0050891)2.76901184
129positive regulation of type 2 immune response (GO:0002830)2.75269238
130sexual reproduction (GO:0019953)2.74492184
131retrograde transport, vesicle recycling within Golgi (GO:0000301)2.74087819
132regulation of tolerance induction (GO:0002643)2.73638533
133chromosome organization involved in meiosis (GO:0070192)2.72902092
134detection of molecule of bacterial origin (GO:0032490)2.71124258
135diterpenoid biosynthetic process (GO:0016102)2.70405021
136xenobiotic catabolic process (GO:0042178)2.69263758
137drug catabolic process (GO:0042737)2.68846953
138nonribosomal peptide biosynthetic process (GO:0019184)2.68589497
139establishment of protein localization to Golgi (GO:0072600)2.67997057
140establishment of tissue polarity (GO:0007164)2.67501670
141establishment of planar polarity (GO:0001736)2.67501670
142mitotic G1 DNA damage checkpoint (GO:0031571)2.67383117
143spermatid nucleus differentiation (GO:0007289)2.66898426
144meiotic nuclear division (GO:0007126)2.66731203
145regulation of interferon-beta biosynthetic process (GO:0045357)2.66721179
146hormone catabolic process (GO:0042447)2.66557707
147response to pheromone (GO:0019236)2.66498086
148detection of external biotic stimulus (GO:0098581)2.66477253
149single strand break repair (GO:0000012)2.65031437
150establishment of apical/basal cell polarity (GO:0035089)2.64191825
151branched-chain amino acid metabolic process (GO:0009081)2.63873060
152vitamin transmembrane transport (GO:0035461)2.62515846
153one-carbon compound transport (GO:0019755)2.62489733
154meiosis I (GO:0007127)2.62067293
155positive regulation of Rab GTPase activity (GO:0032851)2.59585000
156regulation of Rab GTPase activity (GO:0032313)2.59585000
157exogenous drug catabolic process (GO:0042738)2.59574185
158negative regulation of lymphocyte mediated immunity (GO:0002707)2.56427060
159sulfate transport (GO:0008272)2.55931290
160transcytosis (GO:0045056)2.54857824
161aspartate family amino acid catabolic process (GO:0009068)2.54687779
162carnitine metabolic process (GO:0009437)2.54194950
163genitalia morphogenesis (GO:0035112)2.53971632
164microtubule severing (GO:0051013)2.53741722
165positive regulation of digestive system process (GO:0060456)2.53628231
166keratinocyte proliferation (GO:0043616)2.53217650
167retinoic acid receptor signaling pathway (GO:0048384)2.51914260
168regulation of spindle checkpoint (GO:0090231)2.51508131
169cellular carbohydrate catabolic process (GO:0044275)2.51488283
170negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50142072
171negative regulation of cell killing (GO:0031342)2.50142072
172neutrophil activation involved in immune response (GO:0002283)2.49089864
173regulation of germinal center formation (GO:0002634)2.48650704
174negative regulation of Rho protein signal transduction (GO:0035024)2.47461033
175membrane protein intracellular domain proteolysis (GO:0031293)2.47269919
176fusion of sperm to egg plasma membrane (GO:0007342)11.0199865

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.63633809
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.88786630
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72350888
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.66031427
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.41455682
6LXR_22292898_ChIP-Seq_THP-1_Human2.32523401
7ESR1_21235772_ChIP-Seq_MCF-7_Human2.31487211
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.31042555
9* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.28770309
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.25257786
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.20296670
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.17594249
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14767021
14STAT1_17558387_ChIP-Seq_HELA_Human2.04848838
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02730193
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.01078509
17* SMC4_20622854_ChIP-Seq_HELA_Human1.97193719
18VDR_22108803_ChIP-Seq_LS180_Human1.95415332
19RACK7_27058665_Chip-Seq_MCF-7_Human1.94604367
20GATA4_25053715_ChIP-Seq_YYC3_Human1.94197836
21KAP1_22055183_ChIP-Seq_ESCs_Mouse1.90429751
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.73168859
23ELF1_20517297_ChIP-Seq_JURKAT_Human1.68705091
24BCOR_27268052_Chip-Seq_Bcells_Human1.65985974
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64562176
26LXR_22158963_ChIP-Seq_LIVER_Mouse1.63165366
27PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62969122
28* P68_20966046_ChIP-Seq_HELA_Human1.62341721
29DROSHA_22980978_ChIP-Seq_HELA_Human1.59497140
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59156118
31AR_21909140_ChIP-Seq_LNCAP_Human1.59041351
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.59017952
33STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58844819
34CDX2_20551321_ChIP-Seq_CACO-2_Human1.58723146
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58585708
36VDR_24763502_ChIP-Seq_THP-1_Human1.54613627
37FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54338392
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54335773
39* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.53220736
40WDR5_24793694_ChIP-Seq_LNCAP_Human1.52491838
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.52033093
42SOX2_22085726_ChIP-Seq_NPCs_Mouse1.50322544
43KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49887331
44BCL6_27268052_Chip-Seq_Bcells_Human1.49122422
45KLF5_25053715_ChIP-Seq_YYC3_Human1.48813369
46RAD21_21589869_ChIP-Seq_MESCs_Mouse1.47171558
47TCF7_22412390_ChIP-Seq_EML_Mouse1.46946190
48GATA6_25053715_ChIP-Seq_YYC3_Human1.45876076
49GATA3_21867929_ChIP-Seq_CD8_Mouse1.45070523
50SPI1_23127762_ChIP-Seq_K562_Human1.42362996
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.41550686
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41306385
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40853135
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40699501
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40493873
56CTCF_27219007_Chip-Seq_Bcells_Human1.38879111
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.36538581
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36046130
59VDR_21846776_ChIP-Seq_THP-1_Human1.35570160
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.32708575
61* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32589513
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30829626
63GATA1_19941826_ChIP-Seq_K562_Human1.30080001
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28729823
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28411604
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.28266736
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.27109788
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26103325
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26082192
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25827876
71FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24099857
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.23109810
73MAF_26560356_Chip-Seq_TH1_Human1.22559821
74AHR_22903824_ChIP-Seq_MCF-7_Human1.22496087
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.21884929
76P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.21568555
77P53_21459846_ChIP-Seq_SAOS-2_Human1.21500012
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20916629
79* TP63_23658742_ChIP-Seq_EP156T_Human1.20114597
80KDM2B_26808549_Chip-Seq_DND41_Human1.18845068
81RUNX_20019798_ChIP-Seq_JUKART_Human1.18421911
82* PHF8_20622854_ChIP-Seq_HELA_Human1.17998461
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17692993
84CBP_20019798_ChIP-Seq_JUKART_Human1.17692993
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16962271
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.16748210
87SOX11_22085726_ChIP-Seq_ESNs_Mouse1.16011463
88ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15183722
89SA1_27219007_Chip-Seq_Bcells_Human1.14706834
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14702909
91KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14424384
92VDR_24787735_ChIP-Seq_THP-1_Human1.14155212
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.13960641
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13471175
95CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12807883
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.12553974
97* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.12535902
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12329986
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12165765
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11397901
101TDRD3_21172665_ChIP-Seq_MCF-7_Human1.11388142
102P300_27268052_Chip-Seq_Bcells_Human1.10144865
103TBX20_22328084_ChIP-Seq_HEART_Mouse1.09931268
104TBX20_22080862_ChIP-Seq_HEART_Mouse1.09931268
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.09149004
106FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09118314
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09104082
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08813106
109BP1_19119308_ChIP-ChIP_Hs578T_Human1.08311412
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08264233
111CTCF_20526341_ChIP-Seq_ESCs_Human1.08191452
112ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07298507
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06253626
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06056067
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05433346
116SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.05346921
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04535180
118SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03688606
119RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03678770
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03427637
121* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03288303
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03187542
123ESR2_21235772_ChIP-Seq_MCF-7_Human1.02391419
124SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02036471
125UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01893215
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01590156
127GATA1_19941827_ChIP-Seq_MEL_Mouse1.01580859
128KDM2B_26808549_Chip-Seq_K562_Human1.01458194
129MAF_26560356_Chip-Seq_TH2_Human1.01174451
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00898202
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00898202
132CREB1_26743006_Chip-Seq_LNCaP_Human1.00790134
133CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00705617
134MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00523520
135* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00032461
136ESET_19884257_ChIP-Seq_ESCs_Mouse0.99676590
137UTX_26944678_Chip-Seq_JUKART_Human0.98935321
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98427794
139GF1_26923725_Chip-Seq_HPCs_Mouse0.98342536
140ERG_20517297_ChIP-Seq_VCAP_Human0.98300242
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98137139
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.97857681
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97613790
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97325667
145TP63_22573176_ChIP-Seq_HFKS_Human0.95622431
146GATA2_19941826_ChIP-Seq_K562_Human0.94993470
147* CEBPB_22108803_ChIP-Seq_LS180_Human0.94508879
148PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94475616
149RUNX1_22412390_ChIP-Seq_EML_Mouse0.94460300
150EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94098993
151NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93535398
152EP300_21415370_ChIP-Seq_HL-1_Mouse0.93364044
153* UBF1/2_26484160_Chip-Seq_HMECs_Human0.93349675
154RAC3_21632823_ChIP-Seq_H3396_Human0.92065214
155SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90810158
156NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90697605
157E2F1_20622854_ChIP-Seq_HELA_Human0.90575549
158SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89946419
159CSB_26484114_Chip-Seq_FIBROBLAST_Human0.89740858
160JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.88685520
161NANOG_20526341_ChIP-Seq_ESCs_Human0.88006354
162RARA_24833708_ChIP-Seq_LIVER_Mouse0.87922504
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.87823095
164SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86940156
165* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86649232
166SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86451169
167* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85989848
168KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85080744
169ZNF263_19887448_ChIP-Seq_K562_Human0.85045765
170* CDX2_22108803_ChIP-Seq_LS180_Human0.83815919
171OCT4_18555785_Chip-Seq_ESCs_Mouse0.83636944
172HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83618176
173MYC_27129775_Chip-Seq_CORNEA_Mouse0.83577759
174TRIM28_21343339_ChIP-Seq_HEK293_Human0.82990844
175STAT1_20625510_ChIP-Seq_HELA_Human0.82475237
176* SOX2_21211035_ChIP-Seq_LN229_Human0.82197859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.30373170
2MP0004381_abnormal_hair_follicle4.81364704
3MP0005171_absent_coat_pigmentation4.53648095
4MP0005408_hypopigmentation3.90605487
5MP0004019_abnormal_vitamin_homeostasis3.69644660
6MP0000372_irregular_coat_pigmentation3.46987802
7MP0002132_abnormal_respiratory_system3.15752178
8MP0005360_urolithiasis3.12636745
9MP0005075_abnormal_melanosome_morpholog3.01450045
10MP0004043_abnormal_pH_regulation2.99673364
11MP0003698_abnormal_male_reproductive2.97383967
12MP0008004_abnormal_stomach_pH2.90040874
13MP0000015_abnormal_ear_pigmentation2.87556506
14MP0003136_yellow_coat_color2.82158638
15MP0001929_abnormal_gametogenesis2.73140598
16MP0003878_abnormal_ear_physiology2.61594102
17MP0005377_hearing/vestibular/ear_phenot2.61594102
18MP0001765_abnormal_ion_homeostasis2.57908885
19MP0002138_abnormal_hepatobiliary_system2.47113130
20MP0005248_abnormal_Harderian_gland2.45496507
21MP0009643_abnormal_urine_homeostasis2.23715805
22MP0001666_abnormal_nutrient_absorption2.22269786
23MP0004264_abnormal_extraembryonic_tissu2.18555461
24MP0000579_abnormal_nail_morphology2.17830503
25MP0005365_abnormal_bile_salt2.15714524
26MP0005670_abnormal_white_adipose2.12702161
27MP0005332_abnormal_amino_acid2.10046508
28MP0000371_diluted_coat_color2.05004684
29MP0002653_abnormal_ependyma_morphology2.04570223
30MP0005409_darkened_coat_color2.01365579
31MP0003453_abnormal_keratinocyte_physiol1.99798000
32MP0005636_abnormal_mineral_homeostasis1.97778057
33MP0002139_abnormal_hepatobiliary_system1.97368158
34MP0005083_abnormal_biliary_tract1.94102216
35MP0005085_abnormal_gallbladder_physiolo1.93143867
36MP0001958_emphysema1.91482616
37MP0002877_abnormal_melanocyte_morpholog1.91150213
38MP0008260_abnormal_autophagy1.90852952
39MP0005451_abnormal_body_composition1.84491621
40MP0003191_abnormal_cellular_cholesterol1.79896833
41MP0002095_abnormal_skin_pigmentation1.79733548
42MP0001756_abnormal_urination1.76790448
43MP0002210_abnormal_sex_determination1.71876865
44MP0005084_abnormal_gallbladder_morpholo1.67268724
45MP0003303_peritoneal_inflammation1.66816548
46MP0005174_abnormal_tail_pigmentation1.65948524
47MP0002136_abnormal_kidney_physiology1.62009877
48MP0003436_decreased_susceptibility_to1.61586080
49MP0003941_abnormal_skin_development1.61209593
50MP0003300_gastrointestinal_ulcer1.60576416
51MP0002161_abnormal_fertility/fecundity1.59953206
52MP0008875_abnormal_xenobiotic_pharmacok1.57984468
53MP0001145_abnormal_male_reproductive1.57238035
54MP0000566_synostosis1.57194654
55MP0001324_abnormal_eye_pigmentation1.50290573
56MP0003252_abnormal_bile_duct1.49334565
57MP0008995_early_reproductive_senescence1.49189105
58MP0001873_stomach_inflammation1.46613778
59MP0002796_impaired_skin_barrier1.43495572
60MP0009379_abnormal_foot_pigmentation1.40140338
61MP0001849_ear_inflammation1.39666040
62MP0003828_pulmonary_edema1.38673677
63MP0005257_abnormal_intraocular_pressure1.38194288
64MP0000653_abnormal_sex_gland1.37050118
65MP0004782_abnormal_surfactant_physiolog1.35368311
66MP0010678_abnormal_skin_adnexa1.33609204
67MP0003172_abnormal_lysosome_physiology1.33083836
68MP0000467_abnormal_esophagus_morphology1.30092642
69MP0002419_abnormal_innate_immunity1.26428503
70MP0004947_skin_inflammation1.22511102
71MP0002928_abnormal_bile_duct1.21612347
72MP0002277_abnormal_respiratory_mucosa1.21141290
73MP0005666_abnormal_adipose_tissue1.17451115
74MP0004272_abnormal_basement_membrane1.16727628
75MP0001764_abnormal_homeostasis1.16329086
76MP0005025_abnormal_response_to1.16028773
77MP0005058_abnormal_lysosome_morphology1.15442036
78MP0001881_abnormal_mammary_gland1.15420495
79MP0001216_abnormal_epidermal_layer1.13323558
80MP0002075_abnormal_coat/hair_pigmentati1.13228800
81MP0000490_abnormal_crypts_of1.12759171
82MP0000383_abnormal_hair_follicle1.10301225
83MP0008877_abnormal_DNA_methylation1.07494199
84MP0001186_pigmentation_phenotype1.06452368
85MP0003950_abnormal_plasma_membrane1.05899662
86MP0004883_abnormal_blood_vessel1.04354484
87MP0003566_abnormal_cell_adhesion1.00855184
88MP0003806_abnormal_nucleotide_metabolis1.00098738
89MP0006054_spinal_hemorrhage0.99751874
90MP0002098_abnormal_vibrissa_morphology0.99356147
91MP0000462_abnormal_digestive_system0.98990736
92MP0001533_abnormal_skeleton_physiology0.98033926
93MP0001835_abnormal_antigen_presentation0.97978437
94MP0009278_abnormal_bone_marrow0.97667678
95MP0005623_abnormal_meninges_morphology0.97518052
96MP0006082_CNS_inflammation0.97310585
97MP0000377_abnormal_hair_follicle0.96878734
98MP0005164_abnormal_response_to0.95539326
99MP0009785_altered_susceptibility_to0.95440639
100MP0003786_premature_aging0.95327517
101MP0001664_abnormal_digestion0.94790424
102MP0001348_abnormal_lacrimal_gland0.94216814
103MP0008961_abnormal_basal_metabolism0.90764418
104MP0003011_delayed_dark_adaptation0.90629042
105MP0001851_eye_inflammation0.89690672
106MP0005387_immune_system_phenotype0.89009071
107MP0001790_abnormal_immune_system0.89009071
108MP0003705_abnormal_hypodermis_morpholog0.88259324
109MP0000858_altered_metastatic_potential0.87214761
110MP0000367_abnormal_coat/_hair0.86671055
111MP0000685_abnormal_immune_system0.84783869
112MP0003195_calcinosis0.84210256
113MP0005501_abnormal_skin_physiology0.83987137
114MP0005023_abnormal_wound_healing0.81109647
115MP0010234_abnormal_vibrissa_follicle0.80837311
116MP0003115_abnormal_respiratory_system0.80266643
117MP0003186_abnormal_redox_activity0.76991308
118MP0004484_altered_response_of0.76508428
119MP0000470_abnormal_stomach_morphology0.75412428
120MP0001663_abnormal_digestive_system0.75355249
121MP0002160_abnormal_reproductive_system0.74441181
122MP0005220_abnormal_exocrine_pancreas0.74340173
123MP0000465_gastrointestinal_hemorrhage0.73778524
124MP0002282_abnormal_trachea_morphology0.73101847
125MP0005166_decreased_susceptibility_to0.72145062
126MP0004147_increased_porphyrin_level0.71997806
127MP0000678_abnormal_parathyroid_gland0.71992246
128MP0005310_abnormal_salivary_gland0.71928960
129MP0005375_adipose_tissue_phenotype0.71911782
130MP0003045_fibrosis0.70285751
131MP0005381_digestive/alimentary_phenotyp0.69294547
132MP0005319_abnormal_enzyme/_coenzyme0.69268851
133MP0002249_abnormal_larynx_morphology0.69135702
134MP0005275_abnormal_skin_tensile0.68650191
135MP0002060_abnormal_skin_morphology0.67996417
136MP0000681_abnormal_thyroid_gland0.67975228
137MP0009053_abnormal_anal_canal0.67757977
138MP0000538_abnormal_urinary_bladder0.66928779
139MP0002723_abnormal_immune_serum0.66364570
140MP0002452_abnormal_antigen_presenting0.66192495
141MP0000569_abnormal_digit_pigmentation0.66181372
142MP0000537_abnormal_urethra_morphology0.65676330
143MP0002405_respiratory_system_inflammati0.65320697
144MP0010155_abnormal_intestine_physiology0.64736739
145MP0010368_abnormal_lymphatic_system0.64668542
146MP0002295_abnormal_pulmonary_circulatio0.63729792
147MP0002133_abnormal_respiratory_system0.63265045
148MP0005388_respiratory_system_phenotype0.63265045
149MP0005000_abnormal_immune_tolerance0.62931306
150MP0002998_abnormal_bone_remodeling0.61797213
151MP0002135_abnormal_kidney_morphology0.61700032
152MP0002118_abnormal_lipid_homeostasis0.61499535
153MP0010771_integument_phenotype0.61275677
154MP0003091_abnormal_cell_migration0.61225411
155MP0008058_abnormal_DNA_repair0.61070429
156MP0002168_other_aberrant_phenotype0.60064217
157MP0002896_abnormal_bone_mineralization0.59915735
158MP0001293_anophthalmia0.58090336
159MP0000477_abnormal_intestine_morphology0.57521478
160MP0000762_abnormal_tongue_morphology0.56512727
161MP0003724_increased_susceptibility_to0.56314438
162MP0005395_other_phenotype0.56258138
163MP0003693_abnormal_embryo_hatching0.53258862
164MP0005503_abnormal_tendon_morphology0.52536316
165MP0003718_maternal_effect0.51839167
166MP0010352_gastrointestinal_tract_polyps0.50897628
167MP0004233_abnormal_muscle_weight0.50616885
168MP0010329_abnormal_lipoprotein_level0.50201422
169MP0000534_abnormal_ureter_morphology0.48503159
170MP0003646_muscle_fatigue0.47337160

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.80229559
2Absent/shortened dynein arms (HP:0200106)7.59744702
3Dynein arm defect of respiratory motile cilia (HP:0012255)7.59744702
4Abnormal respiratory motile cilium morphology (HP:0005938)5.49303530
5Abnormal respiratory epithelium morphology (HP:0012253)5.49303530
6Abnormal respiratory motile cilium physiology (HP:0012261)5.38397772
7Chronic bronchitis (HP:0004469)5.16285047
8Gout (HP:0001997)5.15464880
9Abnormality of renal excretion (HP:0011036)4.99023006
10Hyperactive renin-angiotensin system (HP:0000841)4.66776417
11Abnormality of chloride homeostasis (HP:0011422)4.59460317
12Abnormal ciliary motility (HP:0012262)4.35309734
13Abnormal urine output (HP:0012590)4.24763642
14Polyuria (HP:0000103)4.20863557
15Rhinitis (HP:0012384)4.13860431
16Hypokalemic alkalosis (HP:0001949)4.11404069
17Hyperuricemia (HP:0002149)3.86685987
18Increased purine levels (HP:0004368)3.86685987
19Increased circulating renin level (HP:0000848)3.83125918
20Metabolic alkalosis (HP:0200114)3.80632752
21Infertility (HP:0000789)3.78792596
22Hypomagnesemia (HP:0002917)3.75769862
23Polydipsia (HP:0001959)3.73538358
24Abnormal drinking behavior (HP:0030082)3.73538358
25Renal salt wasting (HP:0000127)3.73204271
26Proximal tubulopathy (HP:0000114)3.72141124
27Nasal polyposis (HP:0100582)3.69000356
28Tubular atrophy (HP:0000092)3.63870927
29Abnormality of the nasal mucosa (HP:0000433)3.51061971
30Tubulointerstitial fibrosis (HP:0005576)3.41915959
31Tubulointerstitial nephritis (HP:0001970)3.34110994
32Asymmetric septal hypertrophy (HP:0001670)3.31684547
33Abnormality of purine metabolism (HP:0004352)3.31076839
34Abnormality of magnesium homeostasis (HP:0004921)3.26817290
35Abnormality of the renal medulla (HP:0100957)3.04451035
36Male infertility (HP:0003251)3.03825340
37Hyperglycinuria (HP:0003108)2.99631049
38Bronchitis (HP:0012387)2.98546400
39Vascular calcification (HP:0004934)2.97156647
40Ocular albinism (HP:0001107)2.96336612
41Tubulointerstitial abnormality (HP:0001969)2.92600709
42Tetany (HP:0001281)2.90380701
43White forelock (HP:0002211)2.89253642
44Bronchiectasis (HP:0002110)2.88772806
45Lip pit (HP:0100267)2.87410347
46Milia (HP:0001056)2.80500791
47Abnormality of the renal cortex (HP:0011035)2.77773299
48Chronic sinusitis (HP:0011109)2.76951201
49Cardiovascular calcification (HP:0011915)2.76692600
50Distal lower limb muscle weakness (HP:0009053)2.76445034
51Hyperaldosteronism (HP:0000859)2.73630158
52Abnormality of renin-angiotensin system (HP:0000847)2.73085756
53Abnormality of nail color (HP:0100643)2.65401901
54Eczematoid dermatitis (HP:0000976)2.63421717
55Abnormality of renal resorption (HP:0011038)2.58295857
56Ileus (HP:0002595)2.57228526
57Atelectasis (HP:0100750)2.57178121
58Patchy hypopigmentation of hair (HP:0011365)2.54740073
59Hypercalciuria (HP:0002150)2.54326310
60Thick nail (HP:0001805)2.52007902
61Bell-shaped thorax (HP:0001591)2.50913858
62Severe visual impairment (HP:0001141)2.50218797
63Blue irides (HP:0000635)2.43532619
64Recurrent bacterial skin infections (HP:0005406)2.42819249
65Abnormal spermatogenesis (HP:0008669)2.38601615
66Abnormality of nucleobase metabolism (HP:0010932)2.37473269
67Onycholysis (HP:0001806)2.35303440
68Iris hypopigmentation (HP:0007730)2.33623859
69Plantar hyperkeratosis (HP:0007556)2.33107427
70Alkalosis (HP:0001948)2.32097238
71Nephronophthisis (HP:0000090)2.28713748
72Popliteal pterygium (HP:0009756)2.27649243
73Widely patent fontanelles and sutures (HP:0004492)2.26590869
74Recurrent abscess formation (HP:0002722)2.25327927
75Glycosuria (HP:0003076)2.25002603
76Abnormality of urine glucose concentration (HP:0011016)2.25002603
77Ventricular fibrillation (HP:0001663)2.22031362
78Malnutrition (HP:0004395)2.19797135
79Dyschromatopsia (HP:0007641)2.18673659
80Cone-rod dystrophy (HP:0000548)2.17811779
81Pili torti (HP:0003777)2.17361385
82Abnormality of serine family amino acid metabolism (HP:0010894)2.16179536
83Abnormality of glycine metabolism (HP:0010895)2.16179536
84Aplasia/Hypoplasia of the macula (HP:0008059)2.15747291
85Stage 5 chronic kidney disease (HP:0003774)2.15141259
86Nephrocalcinosis (HP:0000121)2.11516147
87Glucose intolerance (HP:0000833)2.08693954
88Increased IgE level (HP:0003212)2.07675386
89Reticulocytopenia (HP:0001896)2.07443306
90Myositis (HP:0100614)2.06859292
91Impulsivity (HP:0100710)2.05720433
92Congenital sensorineural hearing impairment (HP:0008527)2.04975739
93Abnormality of glutamine family amino acid metabolism (HP:0010902)2.02261263
94Dehydration (HP:0001944)1.98162363
95Potter facies (HP:0002009)1.97615612
96Facial shape deformation (HP:0011334)1.97615612
97Abnormal hemoglobin (HP:0011902)1.97061990
98Renal tubular acidosis (HP:0001947)1.97061093
99Abnormality of potassium homeostasis (HP:0011042)1.96767526
100Aplasia/Hypoplasia affecting the retina (HP:0008061)1.96591473
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93526173
102Hypokalemia (HP:0002900)1.92249459
103Generalized aminoaciduria (HP:0002909)1.91712588
104Ketoacidosis (HP:0001993)1.89468426
105Chronic hepatic failure (HP:0100626)1.89443963
106Delayed epiphyseal ossification (HP:0002663)1.88240055
107Gingivitis (HP:0000230)1.88087984
108Abnormality of the salivary glands (HP:0010286)1.87934523
109Fragile nails (HP:0001808)1.86169132
110Palmoplantar hyperkeratosis (HP:0000972)1.86124797
111Chronic otitis media (HP:0000389)1.85620974
112Hypoplasia of dental enamel (HP:0006297)1.85271460
113Orchitis (HP:0100796)1.85039144
114Occipital encephalocele (HP:0002085)1.84695551
115Atrophic scars (HP:0001075)1.83016279
116Alopecia of scalp (HP:0002293)1.82929290
117Generalized hypopigmentation (HP:0007513)1.82844588
118Exercise-induced myalgia (HP:0003738)1.82214282
119Ketosis (HP:0001946)1.79616334
120Abnormality of macrophages (HP:0004311)1.79295863
121Bony spicule pigmentary retinopathy (HP:0007737)1.78813710
122Hyperkalemia (HP:0002153)1.78713419
123Azoospermia (HP:0000027)1.77939183
124Hyperglycinemia (HP:0002154)1.77619600
125Decreased central vision (HP:0007663)1.76691296
126Abnormality of molar (HP:0011077)1.75357075
127Abnormality of molar morphology (HP:0011070)1.75357075
128Recurrent sinusitis (HP:0011108)1.75274160
129Abnormality of permanent molar morphology (HP:0011071)1.74954584
130Abnormality of the dental root (HP:0006486)1.74954584
131Taurodontia (HP:0000679)1.74954584
132Recurrent gram-negative bacterial infections (HP:0005420)1.74916720
133Absent frontal sinuses (HP:0002688)1.74511744
134Hypopigmentation of the fundus (HP:0007894)1.73689363
135Thin bony cortex (HP:0002753)1.72745529
136Subcapsular cataract (HP:0000523)1.70638948
137Abnormal blistering of the skin (HP:0008066)1.69578940
138Palmar hyperkeratosis (HP:0010765)1.68601572
139Aplasia/Hypoplasia of the fovea (HP:0008060)1.67779888
140Hypoplasia of the fovea (HP:0007750)1.67779888
141Nephrolithiasis (HP:0000787)1.67366256
142Hyperphosphaturia (HP:0003109)1.67340696
143Right ventricular cardiomyopathy (HP:0011663)1.67040021
144Methylmalonic aciduria (HP:0012120)1.66196757
145Tachypnea (HP:0002789)1.65844893
146Recurrent otitis media (HP:0000403)1.65556279
147Hyperphosphatemia (HP:0002905)1.65211308
148Dicarboxylic aciduria (HP:0003215)1.64069728
149Abnormality of dicarboxylic acid metabolism (HP:0010995)1.64069728
150Abnormal hair laboratory examination (HP:0003328)1.63099982
151Optic neuritis (HP:0100653)1.61527639
152Retrobulbar optic neuritis (HP:0100654)1.61527639
153Abnormality of the neuromuscular junction (HP:0003398)1.60512236
154Fatigable weakness (HP:0003473)1.60512236
155Abnormality of the fovea (HP:0000493)1.60394649
156Nail dystrophy (HP:0008404)1.59450661
157Interstitial pulmonary disease (HP:0006530)1.59149040
158Recurrent bronchitis (HP:0002837)1.58329776
159Amelogenesis imperfecta (HP:0000705)1.56927231
160Resting tremor (HP:0002322)1.54697791
161Abnormality of the distal phalanges of the toes (HP:0010182)1.54159609
162Peripheral hypomyelination (HP:0007182)1.51908502
163Elevated erythrocyte sedimentation rate (HP:0003565)1.51841569
164Abnormal rod and cone electroretinograms (HP:0008323)1.51452025
165Progressive sensorineural hearing impairment (HP:0000408)1.50538058
166Hand muscle atrophy (HP:0009130)1.48406623
167Macular degeneration (HP:0000608)1.47988804
168Amyloidosis (HP:0011034)1.44611558
169Muscle fiber splitting (HP:0003555)1.43369287
170Recurrent pneumonia (HP:0006532)1.43306558
171Abnormality of the dental pulp (HP:0006479)1.42600811
172Hypotrichosis (HP:0001006)1.41171644

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.33578870
2PDK36.33578870
3WNK44.84229225
4PDK24.59010375
5TESK13.43240835
6STK393.14211756
7PRKD33.11179693
8RIPK42.59260430
9MAP3K22.56358380
10WNK32.35615005
11EPHA22.22937104
12OXSR12.18984604
13ICK2.13460610
14MAPKAPK31.96727437
15CSK1.95904488
16STK38L1.94869233
17BCKDK1.93142936
18CDK121.90403737
19GRK61.88491830
20BLK1.77706983
21MAPK151.68465518
22LMTK21.68124893
23MST41.66609595
24MAP2K31.65197195
25SMG11.63122641
26NEK61.56829718
27DYRK1B1.42506895
28MUSK1.39356980
29FRK1.39189191
30MAP2K21.38283890
31STK381.37926298
32MAP3K111.37322637
33KSR21.37054101
34TYK21.33063204
35TIE11.26544062
36TLK11.24394680
37STK241.23881881
38MAP3K11.22011915
39MARK21.18732203
40IRAK41.15623818
41MST1R1.13264840
42TTK1.12693693
43NUAK11.10696659
44TBK11.07108333
45TNK21.06377455
46SIK31.06109249
47WNK11.05172811
48MAP3K31.02969276
49NEK21.01301289
50IRAK31.00743072
51DYRK30.99871774
52MAP3K70.99093844
53PIK3CG0.97016681
54LATS10.93433968
55BRD40.93391446
56GRK10.91643630
57MAP3K60.91494167
58MAP2K60.91231481
59NLK0.88055331
60IRAK10.84569651
61PTK2B0.84538112
62NME10.76857101
63RPS6KA20.73197851
64PRKD20.72884256
65INSRR0.71737934
66PNCK0.71648188
67ZAK0.70848281
68MATK0.70748042
69PAK40.70644260
70HCK0.69336988
71FGR0.69185653
72MAP4K10.68591590
73PLK40.68588605
74ERN10.66050107
75STK30.65077139
76JAK30.64893833
77TGFBR20.64830411
78SIK10.63536140
79JAK20.61698014
80EEF2K0.58196509
81CAMK1G0.55920188
82NEK90.53381394
83IRAK20.53334601
84PRKD10.52369023
85PTK60.52322374
86ARAF0.51820353
87TRPM70.51322808
88MAPK120.50770056
89SIK20.50140288
90RIPK10.49988600
91MYLK0.49635513
92PBK0.48766637
93RET0.47876796
94CHEK20.46838270
95EPHB20.45862026
96SGK2230.45567207
97SGK4940.45567207
98ZAP700.45430600
99PRKCI0.45354620
100GSK3A0.44733698
101FGFR30.43826092
102CDC42BPA0.43646422
103FGFR40.43593622
104FER0.43553802
105LRRK20.43466960
106MTOR0.43152434
107KDR0.41909878
108TRIB30.40860681
109RPS6KA10.39525998
110MAPKAPK50.38643695
111NME20.37165863
112SGK30.37007786
113BTK0.36695532
114PIM10.36614351
115FYN0.36611784
116AURKB0.36083332
117PRKG20.35999803
118PRKAA10.35864535
119MAPK70.34885675
120IKBKE0.34201192
121EPHB10.34078862
122HIPK20.33288698
123PDK10.32982940
124JAK10.32384849
125CAMK1D0.31856430
126PRKCH0.31757923
127MAP3K130.31463299
128MAP3K80.31242321
129AKT30.30845514
130YES10.30443148
131IKBKB0.30380547
132CHUK0.30359727
133PRKAA20.30184597
134MARK30.29997982
135EIF2AK10.29742444
136ERBB30.28807183
137PTK20.27329058
138CDK60.26619996
139TAOK10.26235551
140TYRO30.26030821
141STK100.23758863
142PAK10.23568435
143PDPK10.22999235
144PINK10.21827389
145MELK0.21122891
146RPS6KB20.18783712
147CDK70.18115924
148PDGFRB0.15847799
149CHEK10.15178067
150ERBB20.14542443
151DDR20.14237468
152PLK10.13989849
153PAK20.13960043
154MET0.13801252
155PKN20.12258181
156PASK0.11905196

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.54159629
2Pyruvate metabolism_Homo sapiens_hsa006202.89215033
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.83481233
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.64673133
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.59745885
6Fatty acid degradation_Homo sapiens_hsa000712.58150562
7Vitamin digestion and absorption_Homo sapiens_hsa049772.44692689
8Glutathione metabolism_Homo sapiens_hsa004802.42651496
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40539054
10Protein digestion and absorption_Homo sapiens_hsa049742.37529494
11Fatty acid biosynthesis_Homo sapiens_hsa000612.35053076
12Mineral absorption_Homo sapiens_hsa049782.25059572
13Glycerolipid metabolism_Homo sapiens_hsa005612.19665063
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.15619248
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12172966
16Fat digestion and absorption_Homo sapiens_hsa049751.94595878
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93884693
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88734911
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.80890184
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.80437779
21Osteoclast differentiation_Homo sapiens_hsa043801.79070624
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78986223
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76903190
24Fructose and mannose metabolism_Homo sapiens_hsa000511.73508386
25Acute myeloid leukemia_Homo sapiens_hsa052211.70680997
26Fatty acid metabolism_Homo sapiens_hsa012121.69609602
27Carbon metabolism_Homo sapiens_hsa012001.59180277
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58830147
29Selenocompound metabolism_Homo sapiens_hsa004501.55846643
30PPAR signaling pathway_Homo sapiens_hsa033201.53364372
31Endocytosis_Homo sapiens_hsa041441.51219340
32Sulfur metabolism_Homo sapiens_hsa009201.49214228
33Staphylococcus aureus infection_Homo sapiens_hsa051501.48259258
34beta-Alanine metabolism_Homo sapiens_hsa004101.46012602
35Arachidonic acid metabolism_Homo sapiens_hsa005901.40972509
36Leishmaniasis_Homo sapiens_hsa051401.40784299
37Peroxisome_Homo sapiens_hsa041461.38523133
38Butanoate metabolism_Homo sapiens_hsa006501.35282083
39Tuberculosis_Homo sapiens_hsa051521.34481928
40Notch signaling pathway_Homo sapiens_hsa043301.33664898
41Toxoplasmosis_Homo sapiens_hsa051451.33645333
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32816476
43Linoleic acid metabolism_Homo sapiens_hsa005911.32731620
44Graft-versus-host disease_Homo sapiens_hsa053321.32223072
45VEGF signaling pathway_Homo sapiens_hsa043701.32084031
46Autoimmune thyroid disease_Homo sapiens_hsa053201.31770795
47Lysosome_Homo sapiens_hsa041421.31411667
48Pancreatic secretion_Homo sapiens_hsa049721.31382314
49Allograft rejection_Homo sapiens_hsa053301.30749742
50Tryptophan metabolism_Homo sapiens_hsa003801.30746848
51Influenza A_Homo sapiens_hsa051641.30202496
52Renin-angiotensin system_Homo sapiens_hsa046141.26900028
53Malaria_Homo sapiens_hsa051441.26423170
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.25862185
55Chemical carcinogenesis_Homo sapiens_hsa052041.25708287
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24950826
57Folate biosynthesis_Homo sapiens_hsa007901.24295908
58Pentose phosphate pathway_Homo sapiens_hsa000301.21401152
59Lysine degradation_Homo sapiens_hsa003101.15583349
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15512368
61Adipocytokine signaling pathway_Homo sapiens_hsa049201.14837201
62Inositol phosphate metabolism_Homo sapiens_hsa005621.14731611
63Toll-like receptor signaling pathway_Homo sapiens_hsa046201.14447444
64Hepatitis C_Homo sapiens_hsa051601.14120071
65Viral myocarditis_Homo sapiens_hsa054161.13474090
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13400093
67Bile secretion_Homo sapiens_hsa049761.12749431
68Non-small cell lung cancer_Homo sapiens_hsa052231.12043684
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10443963
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10300841
71Maturity onset diabetes of the young_Homo sapiens_hsa049501.08951837
72B cell receptor signaling pathway_Homo sapiens_hsa046621.08549701
73Legionellosis_Homo sapiens_hsa051341.08027763
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07589546
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07260990
76Phagosome_Homo sapiens_hsa041451.06298700
77Measles_Homo sapiens_hsa051621.04384302
78Jak-STAT signaling pathway_Homo sapiens_hsa046301.03185836
79Antigen processing and presentation_Homo sapiens_hsa046121.02911721
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01750269
81Dorso-ventral axis formation_Homo sapiens_hsa043201.00945653
82Arginine and proline metabolism_Homo sapiens_hsa003301.00558242
83Pancreatic cancer_Homo sapiens_hsa052120.98841059
84Histidine metabolism_Homo sapiens_hsa003400.96985437
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95486917
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95090089
87Amoebiasis_Homo sapiens_hsa051460.94218050
88Chemokine signaling pathway_Homo sapiens_hsa040620.93007766
89Thyroid cancer_Homo sapiens_hsa052160.91812126
90Insulin resistance_Homo sapiens_hsa049310.91604523
91Endometrial cancer_Homo sapiens_hsa052130.90890172
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89400807
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88920984
94Vitamin B6 metabolism_Homo sapiens_hsa007500.87949790
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.86476700
96Type I diabetes mellitus_Homo sapiens_hsa049400.83570899
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83184053
98Other glycan degradation_Homo sapiens_hsa005110.82647038
99Choline metabolism in cancer_Homo sapiens_hsa052310.81574190
100Hematopoietic cell lineage_Homo sapiens_hsa046400.81469601
101TNF signaling pathway_Homo sapiens_hsa046680.81040653
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80965564
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79837684
104Prostate cancer_Homo sapiens_hsa052150.79129290
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77088831
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.76889937
107Chronic myeloid leukemia_Homo sapiens_hsa052200.76074645
108Insulin signaling pathway_Homo sapiens_hsa049100.74615717
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73166837
110Biosynthesis of amino acids_Homo sapiens_hsa012300.72926748
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72600717
112Galactose metabolism_Homo sapiens_hsa000520.72496317
113Caffeine metabolism_Homo sapiens_hsa002320.71881520
114Herpes simplex infection_Homo sapiens_hsa051680.71654703
115Starch and sucrose metabolism_Homo sapiens_hsa005000.71334021
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71102504
117Retinol metabolism_Homo sapiens_hsa008300.70505061
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69054239
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68834630
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68792497
121Metabolic pathways_Homo sapiens_hsa011000.68583882
122Small cell lung cancer_Homo sapiens_hsa052220.67720740
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67293243
124ABC transporters_Homo sapiens_hsa020100.66305376
125Huntingtons disease_Homo sapiens_hsa050160.65380668
126Thyroid hormone synthesis_Homo sapiens_hsa049180.64511831
127Sphingolipid metabolism_Homo sapiens_hsa006000.63306895
128Renal cell carcinoma_Homo sapiens_hsa052110.63199430
129Phototransduction_Homo sapiens_hsa047440.62640026
130Tight junction_Homo sapiens_hsa045300.61646588
131Prolactin signaling pathway_Homo sapiens_hsa049170.61483886
132mTOR signaling pathway_Homo sapiens_hsa041500.61445237
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.61081020
134Hepatitis B_Homo sapiens_hsa051610.60603594
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60249550
136Salmonella infection_Homo sapiens_hsa051320.59760441
137Apoptosis_Homo sapiens_hsa042100.59728921
138ErbB signaling pathway_Homo sapiens_hsa040120.58684223
139Proteoglycans in cancer_Homo sapiens_hsa052050.57809758
140Collecting duct acid secretion_Homo sapiens_hsa049660.56066844
141Focal adhesion_Homo sapiens_hsa045100.55411968
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.54845156
143Pertussis_Homo sapiens_hsa051330.54633539
144Glucagon signaling pathway_Homo sapiens_hsa049220.54482843
145Fanconi anemia pathway_Homo sapiens_hsa034600.53986791
146Olfactory transduction_Homo sapiens_hsa047400.53661877
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52970791
148Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52905740
149Sulfur relay system_Homo sapiens_hsa041220.52027359
150Purine metabolism_Homo sapiens_hsa002300.51126261
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.48344265
152Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46728698
153Phenylalanine metabolism_Homo sapiens_hsa003600.41654677
154Gastric acid secretion_Homo sapiens_hsa049710.41076434
155Ribosome_Homo sapiens_hsa030100.40637824
156Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38620028
157ECM-receptor interaction_Homo sapiens_hsa045120.34850560
158Adherens junction_Homo sapiens_hsa045200.34717132
159Drug metabolism - other enzymes_Homo sapiens_hsa009830.31338069
160RNA transport_Homo sapiens_hsa030130.29122636
161Oxidative phosphorylation_Homo sapiens_hsa001900.27665137
162Ether lipid metabolism_Homo sapiens_hsa005650.27360067
163mRNA surveillance pathway_Homo sapiens_hsa030150.25804052
164AMPK signaling pathway_Homo sapiens_hsa041520.25511437
165Basal transcription factors_Homo sapiens_hsa030220.25401944
166Pyrimidine metabolism_Homo sapiens_hsa002400.22260864
167Basal cell carcinoma_Homo sapiens_hsa052170.19058622
168Tyrosine metabolism_Homo sapiens_hsa003500.14274018
169Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13560275
170Cardiac muscle contraction_Homo sapiens_hsa042600.13469630
171Protein export_Homo sapiens_hsa030600.12994376
172N-Glycan biosynthesis_Homo sapiens_hsa005100.12874452

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »