ST6GALNAC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.26487014
2myelination (GO:0042552)6.41511509
3ensheathment of neurons (GO:0007272)6.39411186
4axon ensheathment (GO:0008366)6.39411186
5long-chain fatty acid biosynthetic process (GO:0042759)5.39475221
6negative regulation of protein localization to cell surface (GO:2000009)5.06202557
7myelin maintenance (GO:0043217)4.54629659
8regulation of collateral sprouting (GO:0048670)4.50368510
9peptidyl-tyrosine autophosphorylation (GO:0038083)4.44127148
10negative regulation of neurotransmitter transport (GO:0051589)4.31494751
11apical protein localization (GO:0045176)4.28609030
12DNA double-strand break processing (GO:0000729)4.22400318
13axon extension involved in axon guidance (GO:0048846)4.12656119
14neuron projection extension involved in neuron projection guidance (GO:1902284)4.12656119
15establishment of mitochondrion localization (GO:0051654)4.11929791
16negative regulation of neurotransmitter secretion (GO:0046929)4.10007668
17oligodendrocyte differentiation (GO:0048709)4.07586243
18lateral sprouting from an epithelium (GO:0060601)3.97579979
19chromatin remodeling at centromere (GO:0031055)3.95893986
20somite development (GO:0061053)3.92086246
21cholesterol biosynthetic process (GO:0006695)3.91572733
22L-amino acid import (GO:0043092)3.86720365
23asymmetric protein localization (GO:0008105)3.86359988
24positive regulation of oligodendrocyte differentiation (GO:0048714)3.84968097
25CENP-A containing nucleosome assembly (GO:0034080)3.83536161
26glycerophospholipid catabolic process (GO:0046475)3.82965244
27presynaptic membrane organization (GO:0097090)3.80099010
28cerebral cortex radially oriented cell migration (GO:0021799)3.79949699
29amyloid precursor protein metabolic process (GO:0042982)3.66786662
30limb bud formation (GO:0060174)3.66565305
31GPI anchor biosynthetic process (GO:0006506)3.65351821
32preassembly of GPI anchor in ER membrane (GO:0016254)3.63555843
33regulation of pigment cell differentiation (GO:0050932)3.62781741
34retinal ganglion cell axon guidance (GO:0031290)3.62223290
35import into cell (GO:0098657)3.58735571
36astrocyte development (GO:0014002)3.58030577
37GPI anchor metabolic process (GO:0006505)3.54288558
38photoreceptor cell differentiation (GO:0046530)3.48329837
39eye photoreceptor cell differentiation (GO:0001754)3.48329837
40sterol biosynthetic process (GO:0016126)3.45631773
41response to methylmercury (GO:0051597)3.44395221
42presynaptic membrane assembly (GO:0097105)3.43295117
43membrane tubulation (GO:0097320)3.42308439
44organ growth (GO:0035265)3.40823831
45enteric nervous system development (GO:0048484)3.39298968
46postsynaptic membrane organization (GO:0001941)3.38279236
47histone exchange (GO:0043486)3.35366555
48isoprenoid biosynthetic process (GO:0008299)3.23065619
49negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.21286998
50negative regulation of axonogenesis (GO:0050771)3.19009931
51negative regulation of axon extension (GO:0030517)3.18943909
52protein palmitoylation (GO:0018345)3.18644577
53substantia nigra development (GO:0021762)3.17505160
54mesenchymal cell proliferation (GO:0010463)3.14457894
55DNA replication-independent nucleosome organization (GO:0034724)3.11826427
56DNA replication-independent nucleosome assembly (GO:0006336)3.11826427
57intraciliary transport (GO:0042073)3.11555676
58magnesium ion transport (GO:0015693)3.10784453
59creatine metabolic process (GO:0006600)3.07718219
60negative chemotaxis (GO:0050919)3.03721414
61G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.02195384
62neuron remodeling (GO:0016322)3.01051939
63long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.00235967
64regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.99718857
65neuron cell-cell adhesion (GO:0007158)2.99497044
66dorsal/ventral axis specification (GO:0009950)2.98575216
67long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.97489088
68neuron fate determination (GO:0048664)2.97467028
69glomerular basement membrane development (GO:0032836)2.96670871
70neural tube formation (GO:0001841)2.96120059
71nonmotile primary cilium assembly (GO:0035058)2.96083540
72myelination in peripheral nervous system (GO:0022011)2.95272437
73peripheral nervous system axon ensheathment (GO:0032292)2.95272437
74vocalization behavior (GO:0071625)2.89504569
75negative regulation of axon extension involved in axon guidance (GO:0048843)2.88788394
76regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.87279321
77mannosylation (GO:0097502)2.86870507
78neurotransmitter uptake (GO:0001504)2.86109502
79axon development (GO:0061564)2.86100424
80regulation of non-canonical Wnt signaling pathway (GO:2000050)2.86051807
81positive regulation of glial cell differentiation (GO:0045687)2.85514731
82pyrimidine nucleobase catabolic process (GO:0006208)2.85325673
83negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81998678
84negative regulation of translation, ncRNA-mediated (GO:0040033)2.81998678
85regulation of translation, ncRNA-mediated (GO:0045974)2.81998678
86neuron recognition (GO:0008038)2.81154411
87regulation of somitogenesis (GO:0014807)2.80473539
88adult walking behavior (GO:0007628)2.80281877
89epithelial cilium movement (GO:0003351)2.79713139
90head development (GO:0060322)2.78570970
91positive regulation of gliogenesis (GO:0014015)2.78314751
92lung-associated mesenchyme development (GO:0060484)2.77474848
93negative regulation of axon guidance (GO:1902668)2.77036533
94cranial nerve morphogenesis (GO:0021602)2.76940044
95negative regulation of execution phase of apoptosis (GO:1900118)2.76914645
96cyclic nucleotide catabolic process (GO:0009214)2.76608079
97microtubule polymerization or depolymerization (GO:0031109)2.75667211
98regulation of lipoprotein metabolic process (GO:0050746)2.75310454
99lymph vessel development (GO:0001945)2.75017913
100neurotransmitter-gated ion channel clustering (GO:0072578)2.71911481
101olfactory bulb development (GO:0021772)2.71668365
102negative regulation of JUN kinase activity (GO:0043508)2.70719200
103glomerular filtration (GO:0003094)2.70207136
104cell proliferation involved in metanephros development (GO:0072203)2.68778493
105glomerular visceral epithelial cell development (GO:0072015)2.67267516
106hindbrain development (GO:0030902)2.65262790
107L-serine metabolic process (GO:0006563)2.65009547
108positive regulation of male gonad development (GO:2000020)2.62858263
109nerve growth factor signaling pathway (GO:0038180)2.61467052
110protein neddylation (GO:0045116)2.60773331
111regulation of development, heterochronic (GO:0040034)2.59969850
112cell proliferation involved in kidney development (GO:0072111)2.59901399
113amino acid import (GO:0043090)2.59875817
114axonal fasciculation (GO:0007413)2.59624407
115response to redox state (GO:0051775)2.59326717
116Golgi to endosome transport (GO:0006895)2.59089662
117ATP-dependent chromatin remodeling (GO:0043044)2.57936407
118paraxial mesoderm development (GO:0048339)2.57506148
119glomerular epithelial cell development (GO:0072310)2.57031156
120protein localization to kinetochore (GO:0034501)2.55682629
121mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55069082
122mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55069082
123positive regulation of pseudopodium assembly (GO:0031274)2.54658969
124glial cell development (GO:0021782)2.52917752
125glycolipid biosynthetic process (GO:0009247)2.51818211
126C-terminal protein lipidation (GO:0006501)2.51787499
127response to lipoprotein particle (GO:0055094)2.51411988
128regulation of cell fate specification (GO:0042659)2.49631802
129cilium morphogenesis (GO:0060271)2.48779808
130cell differentiation involved in metanephros development (GO:0072202)2.47677026
131regulation of oligodendrocyte differentiation (GO:0048713)2.47603434
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.47306309
133somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47306309
134regulation of timing of cell differentiation (GO:0048505)2.46907211
135regulation of posttranscriptional gene silencing (GO:0060147)2.46459386
136regulation of gene silencing by miRNA (GO:0060964)2.46459386
137regulation of gene silencing by RNA (GO:0060966)2.46459386
138negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46249002
139dopamine biosynthetic process (GO:0042416)2.44493982
140glomerulus development (GO:0032835)2.44394794
141artery development (GO:0060840)2.44081654
142DNA replication-dependent nucleosome organization (GO:0034723)2.43889416
143DNA replication-dependent nucleosome assembly (GO:0006335)2.43889416
144mesodermal cell differentiation (GO:0048333)2.42350141
145peptidyl-cysteine modification (GO:0018198)2.41232230
146transmission of nerve impulse (GO:0019226)2.41013683
147amyloid precursor protein catabolic process (GO:0042987)2.40990425
148calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.40942041
149cerebral cortex cell migration (GO:0021795)2.40689868
150smoothened signaling pathway (GO:0007224)2.40653979
151epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39984374
152attachment of spindle microtubules to kinetochore (GO:0008608)2.38586986
153DNA damage response, detection of DNA damage (GO:0042769)2.37907101
154mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.37444152
155negative regulation of DNA recombination (GO:0045910)2.36326380
156appendage development (GO:0048736)2.35708385
157limb development (GO:0060173)2.35708385
158regulation of cell fate commitment (GO:0010453)2.35684976
159mitotic G2/M transition checkpoint (GO:0044818)2.34613046
160central nervous system projection neuron axonogenesis (GO:0021952)2.34516743
161cilium assembly (GO:0042384)2.33260426
162negative regulation of mitotic sister chromatid separation (GO:2000816)2.33207492
163negative regulation of sister chromatid segregation (GO:0033046)2.33207492
164negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.33207492
165negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.33207492
166negative regulation of mitotic sister chromatid segregation (GO:0033048)2.33207492
167short-term memory (GO:0007614)2.33054810
168pre-miRNA processing (GO:0031054)2.32516814
169cell fate commitment involved in formation of primary germ layer (GO:0060795)2.32340007
170cilium organization (GO:0044782)2.32114736
171atrial cardiac muscle cell action potential (GO:0086014)2.29241563
172cilium movement (GO:0003341)2.28839820
173replication fork processing (GO:0031297)2.28695974
174kinetochore assembly (GO:0051382)2.28479272
175otic vesicle formation (GO:0030916)2.28248535
176negative regulation of chromosome segregation (GO:0051985)2.28201885
177kinetochore organization (GO:0051383)2.25933655
178regulation of mesoderm development (GO:2000380)2.25837548
179spindle checkpoint (GO:0031577)2.25259596
180ephrin receptor signaling pathway (GO:0048013)2.25234396
181regulation of axon guidance (GO:1902667)2.24556141
182lymphangiogenesis (GO:0001946)2.24054644
183regulation of mitotic metaphase/anaphase transition (GO:0030071)2.23623615
184regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.23623615
185protein localization to synapse (GO:0035418)2.23557108
186regulation of sarcomere organization (GO:0060297)2.22147842
187DNA replication checkpoint (GO:0000076)2.21848432
188mitotic spindle checkpoint (GO:0071174)2.21317917
189axon ensheathment in central nervous system (GO:0032291)11.7051127
190central nervous system myelination (GO:0022010)11.7051127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.50477237
2GBX2_23144817_ChIP-Seq_PC3_Human3.47234824
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33985923
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.25263622
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.02112296
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69837252
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.68018274
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.59506287
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.59335146
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.56439927
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54947725
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38613098
13* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.36566059
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33671125
15TAF15_26573619_Chip-Seq_HEK293_Human2.30110658
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29153363
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28777511
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28777511
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.26359660
20* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24149231
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.17170700
22ZNF274_21170338_ChIP-Seq_K562_Hela2.14475316
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11008822
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.09590232
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06010131
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03526826
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01376804
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.95582397
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95369405
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.95123710
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92940376
32FUS_26573619_Chip-Seq_HEK293_Human1.91482650
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.90856236
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.87991213
35E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82399130
36VDR_22108803_ChIP-Seq_LS180_Human1.81136927
37AR_21572438_ChIP-Seq_LNCaP_Human1.80799608
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.80047573
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78006188
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77794828
41IGF1R_20145208_ChIP-Seq_DFB_Human1.72784657
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68305013
43E2F7_22180533_ChIP-Seq_HELA_Human1.64815567
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64184158
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63998926
46RNF2_27304074_Chip-Seq_NSC_Mouse1.63876367
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.62940823
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60677461
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.60639208
50POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58377652
51LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57786325
52* P300_19829295_ChIP-Seq_ESCs_Human1.57669473
53ER_23166858_ChIP-Seq_MCF-7_Human1.57039598
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56274092
55EWS_26573619_Chip-Seq_HEK293_Human1.52991145
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52843568
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.51565081
58TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46950895
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.41870272
60* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39952564
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.39806383
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39273903
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38886397
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38720644
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38720644
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37965953
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35537931
68* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35036106
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.34453541
70* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34267154
71STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32915794
72* NANOG_18555785_Chip-Seq_ESCs_Mouse1.27284569
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27151839
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.26540900
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.25526521
76IRF1_19129219_ChIP-ChIP_H3396_Human1.25060195
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.22172545
78* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.22036327
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22003764
80DROSHA_22980978_ChIP-Seq_HELA_Human1.21848483
81* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.21811211
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21486301
83* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20752265
84* AR_25329375_ChIP-Seq_VCAP_Human1.19810101
85CMYC_18555785_Chip-Seq_ESCs_Mouse1.19742709
86* STAT3_23295773_ChIP-Seq_U87_Human1.19613572
87* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19609281
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19131166
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17899256
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17762138
91ELK1_19687146_ChIP-ChIP_HELA_Human1.17656130
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16589832
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16101930
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15872195
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.15829154
96* SMAD4_21799915_ChIP-Seq_A2780_Human1.14441263
97SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14229307
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13500757
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13115851
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.12892572
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12663215
102* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12212333
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11709369
104MYC_18940864_ChIP-ChIP_HL60_Human1.11313110
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11277792
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11231859
107BCAT_22108803_ChIP-Seq_LS180_Human1.10518657
108* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10458154
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09823046
110CBP_20019798_ChIP-Seq_JUKART_Human1.09823046
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09549044
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.09438797
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09354726
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08840085
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08342778
116GATA1_26923725_Chip-Seq_HPCs_Mouse1.06809938
117KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06779655
118PRDM14_20953172_ChIP-Seq_ESCs_Human1.06569104
119* TCF4_23295773_ChIP-Seq_U87_Human1.06342502
120* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05976068
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05665391
122* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04293587
123TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03897836
124* P300_18555785_Chip-Seq_ESCs_Mouse1.03652289
125ISL1_27105846_Chip-Seq_CPCs_Mouse1.03229756
126JUN_21703547_ChIP-Seq_K562_Human1.03086764
127FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02759628
128EZH2_27294783_Chip-Seq_NPCs_Mouse1.02630227
129FLI1_27457419_Chip-Seq_LIVER_Mouse1.02199791
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01876192
131TCF4_22108803_ChIP-Seq_LS180_Human1.01802093
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01693597
133P53_22387025_ChIP-Seq_ESCs_Mouse1.00777485
134E2F1_18555785_Chip-Seq_ESCs_Mouse1.00631832
135GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99351776
136SOX9_26525672_Chip-Seq_HEART_Mouse0.98805676
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98381972
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97210059
139KDM2B_26808549_Chip-Seq_REH_Human0.96410752
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95760086
141ARNT_22903824_ChIP-Seq_MCF-7_Human0.95675035
142PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94636369
143* RUNX2_22187159_ChIP-Seq_PCA_Human0.92458721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.59956291
2MP0003880_abnormal_central_pattern3.98511878
3MP0005409_darkened_coat_color3.54583331
4MP0003136_yellow_coat_color3.36812228
5MP0010030_abnormal_orbit_morphology3.06284476
6MP0006292_abnormal_olfactory_placode2.85058872
7MP0003950_abnormal_plasma_membrane2.70978954
8MP0005171_absent_coat_pigmentation2.69338431
9MP0004270_analgesia2.43298185
10MP0004147_increased_porphyrin_level2.41998050
11MP0001529_abnormal_vocalization2.37142498
12MP0004885_abnormal_endolymph2.31596804
13MP0001905_abnormal_dopamine_level2.28156664
14MP0000778_abnormal_nervous_system2.26633384
15MP0005248_abnormal_Harderian_gland2.25641189
16MP0000566_synostosis2.25572901
17MP0004859_abnormal_synaptic_plasticity2.24953389
18MP0001486_abnormal_startle_reflex2.09660661
19MP0003122_maternal_imprinting2.09400236
20MP0002272_abnormal_nervous_system2.09081333
21MP0002938_white_spotting2.02990430
22MP0004142_abnormal_muscle_tone2.02443995
23MP0003690_abnormal_glial_cell1.95807704
24MP0003567_abnormal_fetal_cardiomyocyte1.95086576
25MP0004742_abnormal_vestibular_system1.84944159
26MP0003890_abnormal_embryonic-extraembry1.76313874
27MP0000383_abnormal_hair_follicle1.76135142
28MP0003119_abnormal_digestive_system1.75627595
29MP0008877_abnormal_DNA_methylation1.67129469
30MP0002064_seizures1.66731939
31MP0006072_abnormal_retinal_apoptosis1.66607768
32MP0003634_abnormal_glial_cell1.63816440
33MP0001485_abnormal_pinna_reflex1.63719636
34MP0005410_abnormal_fertilization1.60494006
35MP0001984_abnormal_olfaction1.57355126
36MP0001879_abnormal_lymphatic_vessel1.55170095
37MP0005623_abnormal_meninges_morphology1.52758322
38MP0001188_hyperpigmentation1.52336482
39MP0005423_abnormal_somatic_nervous1.52042142
40MP0003635_abnormal_synaptic_transmissio1.51920669
41MP0002233_abnormal_nose_morphology1.50740932
42MP0006054_spinal_hemorrhage1.48359810
43MP0004381_abnormal_hair_follicle1.48299001
44MP0010678_abnormal_skin_adnexa1.46981905
45MP0003938_abnormal_ear_development1.46733257
46MP0005187_abnormal_penis_morphology1.44233050
47MP0003121_genomic_imprinting1.43775199
48MP0000955_abnormal_spinal_cord1.43424892
49MP0003937_abnormal_limbs/digits/tail_de1.43221672
50MP0006276_abnormal_autonomic_nervous1.43185534
51MP0001286_abnormal_eye_development1.42681223
52MP0002697_abnormal_eye_size1.39396875
53MP0003941_abnormal_skin_development1.37765843
54MP0010094_abnormal_chromosome_stability1.33847513
55MP0009745_abnormal_behavioral_response1.33808515
56MP0008789_abnormal_olfactory_epithelium1.33384206
57MP0002653_abnormal_ependyma_morphology1.33312556
58MP0002092_abnormal_eye_morphology1.32214320
59MP0009250_abnormal_appendicular_skeleto1.30430324
60MP0002751_abnormal_autonomic_nervous1.28957109
61MP0005391_vision/eye_phenotype1.27201408
62MP0003787_abnormal_imprinting1.26763866
63MP0002102_abnormal_ear_morphology1.25289252
64MP0003632_abnormal_nervous_system1.24701242
65MP0003329_amyloid_beta_deposits1.24609607
66MP0008932_abnormal_embryonic_tissue1.23155514
67MP0000647_abnormal_sebaceous_gland1.22948187
68MP0001293_anophthalmia1.22914730
69MP0001968_abnormal_touch/_nociception1.22289459
70MP0002734_abnormal_mechanical_nocicepti1.19830670
71MP0000569_abnormal_digit_pigmentation1.19417831
72MP0002736_abnormal_nociception_after1.17786348
73MP0005394_taste/olfaction_phenotype1.17593547
74MP0005499_abnormal_olfactory_system1.17593547
75MP0003631_nervous_system_phenotype1.17579207
76MP0002249_abnormal_larynx_morphology1.17340668
77MP0005167_abnormal_blood-brain_barrier1.17193096
78MP0002882_abnormal_neuron_morphology1.16845703
79MP0010368_abnormal_lymphatic_system1.16815558
80MP0002572_abnormal_emotion/affect_behav1.15025653
81MP0003385_abnormal_body_wall1.14061561
82MP0002111_abnormal_tail_morphology1.13846837
83MP0002229_neurodegeneration1.13399364
84MP0003633_abnormal_nervous_system1.13383973
85MP0008057_abnormal_DNA_replication1.11128170
86MP0000428_abnormal_craniofacial_morphol1.10743815
87MP0000534_abnormal_ureter_morphology1.08458051
88MP0003878_abnormal_ear_physiology1.07898156
89MP0005377_hearing/vestibular/ear_phenot1.07898156
90MP0008569_lethality_at_weaning1.07404870
91MP0002752_abnormal_somatic_nervous1.07211871
92MP0002009_preneoplasia1.06858436
93MP0000462_abnormal_digestive_system1.05923160
94MP0002063_abnormal_learning/memory/cond1.05532812
95MP0001963_abnormal_hearing_physiology1.05082682
96MP0001324_abnormal_eye_pigmentation1.03878675
97MP0000049_abnormal_middle_ear1.03446080
98MP0004272_abnormal_basement_membrane1.03279696
99MP0002085_abnormal_embryonic_tissue1.02418186
100MP0008058_abnormal_DNA_repair1.02334169
101MP0001346_abnormal_lacrimal_gland1.01687000
102MP0000762_abnormal_tongue_morphology1.01263823
103MP0004215_abnormal_myocardial_fiber1.00979991
104MP0001970_abnormal_pain_threshold1.00956141
105MP0002084_abnormal_developmental_patter1.00932224
106MP0005551_abnormal_eye_electrophysiolog1.00218278
107MP0002234_abnormal_pharynx_morphology0.97231345
108MP0005451_abnormal_body_composition0.96774036
109MP0002735_abnormal_chemical_nociception0.96557464
110MP0002067_abnormal_sensory_capabilities0.94441540
111MP0002066_abnormal_motor_capabilities/c0.93884087
112MP0009703_decreased_birth_body0.93797115
113MP0000026_abnormal_inner_ear0.93148660
114MP0000372_irregular_coat_pigmentation0.92687763
115MP0000613_abnormal_salivary_gland0.92366352
116MP0009672_abnormal_birth_weight0.92343829
117MP0005075_abnormal_melanosome_morpholog0.92088239
118MP0008260_abnormal_autophagy0.91544468
119MP0000579_abnormal_nail_morphology0.91395321
120MP0002152_abnormal_brain_morphology0.91198209
121MP0002184_abnormal_innervation0.89597518
122MP0003935_abnormal_craniofacial_develop0.89452320
123MP0003077_abnormal_cell_cycle0.88911498
124MP0001348_abnormal_lacrimal_gland0.88562153
125MP0005195_abnormal_posterior_eye0.88245530
126MP0002090_abnormal_vision0.88241439
127MP0001851_eye_inflammation0.87824914
128MP0003861_abnormal_nervous_system0.87555104
129MP0002822_catalepsy0.85358206
130MP0000537_abnormal_urethra_morphology0.84699552
131MP0003755_abnormal_palate_morphology0.84677485
132MP0004133_heterotaxia0.83732589
133MP0002638_abnormal_pupillary_reflex0.83541587
134MP0002116_abnormal_craniofacial_bone0.81797209
135MP0003942_abnormal_urinary_system0.81309285
136MP0000631_abnormal_neuroendocrine_gland0.80586104
137MP0009379_abnormal_foot_pigmentation0.80009594
138MP0000639_abnormal_adrenal_gland0.79569706
139MP0009046_muscle_twitch0.78267121
140MP0002932_abnormal_joint_morphology0.77552357
141MP0001440_abnormal_grooming_behavior0.77470733
142MP0001299_abnormal_eye_distance/0.77091835
143MP0004134_abnormal_chest_morphology0.76023100
144MP0005253_abnormal_eye_physiology0.75686663
145MP0001177_atelectasis0.75563938
146MP0005408_hypopigmentation0.74355653
147MP0003656_abnormal_erythrocyte_physiolo0.72118726
148MP0002733_abnormal_thermal_nociception0.71726610
149MP0002557_abnormal_social/conspecific_i0.71109076

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.70924322
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.70924322
3Peripheral hypomyelination (HP:0007182)4.33278912
4Neurofibrillary tangles (HP:0002185)4.28227594
5Abnormality of the corticospinal tract (HP:0002492)4.15816964
6Sensory axonal neuropathy (HP:0003390)4.10668658
7Cerebral hypomyelination (HP:0006808)4.04983136
8Parakeratosis (HP:0001036)3.91243399
9True hermaphroditism (HP:0010459)3.73532325
10Abnormality of the labia minora (HP:0012880)3.53167784
11Anteriorly placed anus (HP:0001545)3.34695724
12Onion bulb formation (HP:0003383)3.30035086
13Pancreatic fibrosis (HP:0100732)3.16554826
14Alacrima (HP:0000522)3.13756487
15Abnormal auditory evoked potentials (HP:0006958)3.07992892
16Colon cancer (HP:0003003)3.02914888
17Hyperglycinemia (HP:0002154)3.01574402
18Spastic gait (HP:0002064)2.94686407
19Absent septum pellucidum (HP:0001331)2.87144773
20Supernumerary spleens (HP:0009799)2.86397615
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.81223392
22Pancreatic cysts (HP:0001737)2.78101607
23White forelock (HP:0002211)2.77488536
24Dysmetria (HP:0001310)2.75011044
25Insidious onset (HP:0003587)2.74359415
26Termporal pattern (HP:0011008)2.74359415
27Cutaneous finger syndactyly (HP:0010554)2.73979775
28High anterior hairline (HP:0009890)2.72973387
29Patchy hypopigmentation of hair (HP:0011365)2.70599264
30Intention tremor (HP:0002080)2.67119796
31Ankle clonus (HP:0011448)2.65818738
32Cerebral inclusion bodies (HP:0100314)2.64665520
33Decreased lacrimation (HP:0000633)2.62928550
34Molar tooth sign on MRI (HP:0002419)2.60539211
35Abnormality of midbrain morphology (HP:0002418)2.60539211
36Increased serum pyruvate (HP:0003542)2.60158412
37Abnormality of glycolysis (HP:0004366)2.60158412
38Diastasis recti (HP:0001540)2.55954854
39Morphological abnormality of the inner ear (HP:0011390)2.54994683
40Hypoplastic pelvis (HP:0008839)2.54421089
41Retinal dysplasia (HP:0007973)2.54223713
42Adrenal hypoplasia (HP:0000835)2.53996255
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.51179451
44Leukodystrophy (HP:0002415)2.50744301
45Bifid tongue (HP:0010297)2.50306006
46Hypoplasia of the iris (HP:0007676)2.49243030
47Cutaneous syndactyly (HP:0012725)2.48689875
48CNS hypomyelination (HP:0003429)2.47012847
49Partial duplication of thumb phalanx (HP:0009944)2.45848797
50Vitreoretinal degeneration (HP:0000655)2.45480467
51Nephronophthisis (HP:0000090)2.41715696
52Thickened helices (HP:0000391)2.41004477
53Partial duplication of the phalanx of hand (HP:0009999)2.40715168
54Abnormality of the septum pellucidum (HP:0007375)2.40251636
55Abnormality of the parietal bone (HP:0002696)2.39719266
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.39211123
57Hypoplastic left heart (HP:0004383)2.38663452
58Medial flaring of the eyebrow (HP:0010747)2.38647624
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38027432
60Esophageal atresia (HP:0002032)2.35732478
61Abnormal lung lobation (HP:0002101)2.35124668
62Hepatoblastoma (HP:0002884)2.34879534
63Gait imbalance (HP:0002141)2.33635998
64Slow saccadic eye movements (HP:0000514)2.33508841
65Aplasia/Hypoplasia of the sternum (HP:0006714)2.33196718
66Short 4th metacarpal (HP:0010044)2.32316180
67Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32316180
68Premature skin wrinkling (HP:0100678)2.32219886
69Nonprogressive disorder (HP:0003680)2.31227309
70Supranuclear gaze palsy (HP:0000605)2.30691288
71Scanning speech (HP:0002168)2.30426855
72Coronal craniosynostosis (HP:0004440)2.30336100
73Myelomeningocele (HP:0002475)2.29438329
74Myokymia (HP:0002411)2.27173845
75Postaxial foot polydactyly (HP:0001830)2.26469564
76Congenital primary aphakia (HP:0007707)2.25376475
77Aplasia/Hypoplasia of the tibia (HP:0005772)2.23728082
78Postaxial hand polydactyly (HP:0001162)2.23632343
79Anencephaly (HP:0002323)2.22626806
80Metaphyseal dysplasia (HP:0100255)2.22061765
81Broad foot (HP:0001769)2.21935541
82Anophthalmia (HP:0000528)2.21891954
83Cupped ear (HP:0000378)2.21519107
84Cortical dysplasia (HP:0002539)2.19737683
85Clumsiness (HP:0002312)2.18647730
86Preaxial foot polydactyly (HP:0001841)2.16454948
87Short tibia (HP:0005736)2.14952817
88Split foot (HP:0001839)2.14083315
89Renal hypoplasia (HP:0000089)2.14006493
90Occipital encephalocele (HP:0002085)2.12687279
91Drooling (HP:0002307)2.11760720
92Preaxial hand polydactyly (HP:0001177)2.11101868
93Metabolic alkalosis (HP:0200114)2.10580246
94Ectopic kidney (HP:0000086)2.08625223
95Megalencephaly (HP:0001355)2.07873964
96Segmental peripheral demyelination/remyelination (HP:0003481)2.07563838
97Sclerocornea (HP:0000647)2.05473851
98Poor speech (HP:0002465)2.04766197
99Septo-optic dysplasia (HP:0100842)2.04710535
100Narrow forehead (HP:0000341)2.03820926
101Meckel diverticulum (HP:0002245)2.03102392
102Abnormality of serine family amino acid metabolism (HP:0010894)2.00751613
103Abnormality of glycine metabolism (HP:0010895)2.00751613
104Nasolacrimal duct obstruction (HP:0000579)2.00686986
105Volvulus (HP:0002580)2.00413670
106Hypomagnesemia (HP:0002917)2.00300202
107Nephrogenic diabetes insipidus (HP:0009806)2.00297003
108Spastic paraparesis (HP:0002313)1.98687636
109Chin dimple (HP:0010751)1.98624645
110Abnormality of the ileum (HP:0001549)1.98527324
111Vaginal atresia (HP:0000148)1.97945101
112Exercise-induced muscle cramps (HP:0003710)1.97595341
113Oligodactyly (hands) (HP:0001180)1.97509310
114Increased corneal curvature (HP:0100692)1.96361019
115Keratoconus (HP:0000563)1.96361019
116Overriding aorta (HP:0002623)1.95256783
117Abnormality of the nasolacrimal system (HP:0000614)1.91395985
118Genital tract atresia (HP:0001827)1.90379494
119Abnormality of the middle phalanges of the toes (HP:0010183)1.90359881
120Optic nerve hypoplasia (HP:0000609)1.88674601
121Abnormality of the renal medulla (HP:0100957)1.88500480
122Trigonocephaly (HP:0000243)1.87842224
123Intellectual disability, moderate (HP:0002342)1.86716297
124Abnormality of the 4th metacarpal (HP:0010012)1.86578048
125Abnormality of abdominal situs (HP:0011620)1.86531310
126Abdominal situs inversus (HP:0003363)1.86531310
127Hypoplastic heart (HP:0001961)1.86441413
128Aplasia/Hypoplasia of the uvula (HP:0010293)1.86030295
129Dandy-Walker malformation (HP:0001305)1.85047601
130Abnormal biliary tract physiology (HP:0012439)1.84579923
131Bile duct proliferation (HP:0001408)1.84579923
132Stenosis of the external auditory canal (HP:0000402)1.84530898
133Excessive salivation (HP:0003781)1.84055495
134Increased circulating renin level (HP:0000848)1.82752834
135Humeroradial synostosis (HP:0003041)1.82727965
136Synostosis involving the elbow (HP:0003938)1.82727965
137Broad-based gait (HP:0002136)1.82509869
138Midline defect of the nose (HP:0004122)1.81947438
139Ependymoma (HP:0002888)1.81487643
140Cystic liver disease (HP:0006706)1.81005589
141Medulloblastoma (HP:0002885)1.80563423
142Oligodactyly (HP:0012165)1.79784254
143Anomalous pulmonary venous return (HP:0010772)1.78082971
144Methylmalonic acidemia (HP:0002912)1.77897214
145Autoamputation (HP:0001218)1.77895720
146Cerebral hemorrhage (HP:0001342)1.76651251
147Congenital hepatic fibrosis (HP:0002612)1.75806682
148Chronic hepatic failure (HP:0100626)1.75115361
149Abnormality of the lacrimal duct (HP:0011481)1.74082172
150Aplasia involving bones of the upper limbs (HP:0009823)1.74081034
151Aplasia of the phalanges of the hand (HP:0009802)1.74081034
152Aplasia involving bones of the extremities (HP:0009825)1.74081034
153Hepatosplenomegaly (HP:0001433)1.72734564
154Abnormality of the pulmonary veins (HP:0011718)1.72614587
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71932454
156Meningocele (HP:0002435)1.71627086
157Partial agenesis of the corpus callosum (HP:0001338)1.71372485
158Prominent occiput (HP:0000269)1.71133778
159Nephroblastoma (Wilms tumor) (HP:0002667)1.71023596
160Lower limb muscle weakness (HP:0007340)1.70553742
161Embryonal renal neoplasm (HP:0011794)1.70193499
162Micropenis (HP:0000054)1.69965978
163Abnormal hair whorl (HP:0010721)1.69364460
164Congenital ichthyosiform erythroderma (HP:0007431)1.68832816
165Irregular epiphyses (HP:0010582)1.68446437
166Blue irides (HP:0000635)1.68368051
167Gonadotropin excess (HP:0000837)1.68313601
168Triphalangeal thumb (HP:0001199)1.67466944
169Breast aplasia (HP:0100783)1.66825936
170Abnormality of chromosome stability (HP:0003220)1.66786469
171Action tremor (HP:0002345)1.65828880
172Aplasia/Hypoplasia of the breasts (HP:0010311)1.65057095
173Duplication of thumb phalanx (HP:0009942)1.64639098
174Intestinal atresia (HP:0011100)1.64380688
175Specific learning disability (HP:0001328)1.64102683
176Conical tooth (HP:0000698)1.63926344
177Abnormality of the heme biosynthetic pathway (HP:0010472)1.63698540
178Biliary tract neoplasm (HP:0100574)1.63680662
179Rhabdomyosarcoma (HP:0002859)1.63291544
180Aplasia/Hypoplasia of the hallux (HP:0008362)1.63271842
181Hypokalemic alkalosis (HP:0001949)1.63138693
182Absent radius (HP:0003974)1.62975567
183Median cleft lip (HP:0000161)1.62830360
184Hyperglycinuria (HP:0003108)1.62703899
185Poor coordination (HP:0002370)1.62403025
186Abnormality of the ischium (HP:0003174)1.62383871
187Bilateral microphthalmos (HP:0007633)1.62332420
188Skull defect (HP:0001362)1.61565922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.53757363
2OXSR13.96086334
3WNK33.78159406
4CASK3.02962861
5BCR2.69589135
6CDK192.64806094
7TRIM282.51876712
8MAPKAPK52.47032603
9PKN12.41450839
10TNIK2.36260874
11EPHB12.34198514
12NEK12.31876584
13PRPF4B2.30377887
14TESK22.26012656
15CDC72.18522028
16TIE12.08054802
17MAP3K42.05627517
18ERBB32.04191656
19CSNK1G32.02780909
20MKNK21.99194452
21CSNK1A1L1.98401821
22DYRK31.97914156
23PLK41.97491163
24WNK41.97207065
25CLK11.96269975
26MET1.85042802
27WNK11.84297087
28WEE11.78037666
29SRPK11.73398964
30CSNK1G11.73109687
31PLK21.67506920
32PLK31.65328529
33EPHA41.64411961
34KDR1.57472939
35FGFR21.55344429
36PNCK1.53859485
37TTK1.52711121
38LIMK11.52128804
39CSNK1G21.48243249
40MAP2K71.47501370
41CAMK2B1.43949747
42NEK61.43742981
43UHMK11.42453160
44ZAK1.38767396
45MARK11.36378309
46MAPK131.29750790
47DYRK21.28085697
48ROCK21.25335866
49NUAK11.24897651
50MUSK1.23184737
51FGR1.15252277
52NTRK11.14216832
53BRSK21.05601837
54FRK1.05247129
55SGK2231.04659067
56SGK4941.04659067
57TGFBR11.03225087
58TSSK61.00721946
59PLK10.97847199
60NTRK30.96889454
61NEK20.95404328
62MARK20.94446866
63NTRK20.92430526
64CAMK2D0.92210479
65RPS6KA40.90852513
66FGFR10.89311306
67MINK10.86908072
68RPS6KA50.84630759
69CAMK2G0.84538356
70MAP4K20.82550925
71BCKDK0.81947827
72MAP3K100.81497119
73PRKCQ0.81429983
74MKNK10.80304117
75ICK0.79254047
76MAPK150.78576912
77TXK0.78549069
78ACVR1B0.77342459
79LATS10.77197066
80STK38L0.75485804
81PBK0.74133584
82INSRR0.73769383
83CAMK2A0.73286536
84CDK140.72860706
85BUB10.71831377
86BMPR1B0.69852951
87CDK50.68985372
88PRKD10.67452041
89PAK60.67436493
90PRKD20.66769868
91FER0.65293966
92STK160.63574538
93PRKCG0.62990711
94ATR0.62687435
95DYRK1A0.62233491
96BRD40.61612143
97CDK11A0.60697997
98CDK150.60682102
99CDK180.60051351
100TYRO30.59823558
101STK30.58030453
102DMPK0.56177354
103MST40.55930349
104EPHA30.55685712
105CHEK20.55666694
106PRKCE0.55385781
107CDK30.53716922
108GRK10.53552700
109CDK80.53059918
110VRK10.53041384
111CCNB10.52293627
112ATM0.52140157
113KIT0.51380415
114PTK2B0.50219768
115ERBB20.49075552
116CSNK1D0.48275181
117FYN0.48018580
118PRKG10.47164263
119PAK30.44174146
120AURKB0.43451316
121PHKG10.43203439
122PHKG20.43203439
123CSNK1A10.41528280
124PRKCH0.41003601
125BRSK10.40500781
126GSK3A0.40329433
127OBSCN0.40193371
128TAF10.39502532
129YES10.39003968
130PRKACB0.38082611
131PINK10.37144955
132CAMK10.35738495
133MAPK70.34859915
134CAMK40.34814749
135PRKD30.34551846
136PASK0.34483574
137LCK0.33626230
138CDK10.33463241
139DYRK1B0.33315514
140TLK10.33080594
141EPHB20.32726010
142SGK20.32363706
143ADRBK20.32168966
144NLK0.31874529
145SRC0.29785912
146MAP2K20.28752676
147ITK0.27989595
148FES0.26895489
149PRKACA0.26116396
150PDPK10.25947850
151INSR0.25570829
152STK100.24361541
153MYLK0.23727507
154IKBKE0.22766358

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.95355206
2Fatty acid elongation_Homo sapiens_hsa000624.12906345
3Steroid biosynthesis_Homo sapiens_hsa001004.00441983
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.88036181
5Ether lipid metabolism_Homo sapiens_hsa005652.88331348
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84208686
7Axon guidance_Homo sapiens_hsa043602.63168009
8Mismatch repair_Homo sapiens_hsa034302.48914091
9Non-homologous end-joining_Homo sapiens_hsa034502.43328551
10Propanoate metabolism_Homo sapiens_hsa006402.36284929
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33579703
12Fanconi anemia pathway_Homo sapiens_hsa034602.19043821
13Protein export_Homo sapiens_hsa030601.92806482
14DNA replication_Homo sapiens_hsa030301.90425560
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.84233466
16Glutamatergic synapse_Homo sapiens_hsa047241.64355464
17Cell cycle_Homo sapiens_hsa041101.56340659
18Sphingolipid metabolism_Homo sapiens_hsa006001.56040185
19Cysteine and methionine metabolism_Homo sapiens_hsa002701.51564571
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45110886
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43779100
22RNA degradation_Homo sapiens_hsa030181.40748288
23Morphine addiction_Homo sapiens_hsa050321.40031393
24Serotonergic synapse_Homo sapiens_hsa047261.35365234
25Spliceosome_Homo sapiens_hsa030401.28381393
26GABAergic synapse_Homo sapiens_hsa047271.27996951
27RNA transport_Homo sapiens_hsa030131.27906863
28RNA polymerase_Homo sapiens_hsa030201.27021834
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26447713
30Long-term depression_Homo sapiens_hsa047301.24884816
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.21533552
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21086217
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20099395
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19740574
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.17786456
36Linoleic acid metabolism_Homo sapiens_hsa005911.17455448
37mRNA surveillance pathway_Homo sapiens_hsa030151.14797111
38Circadian entrainment_Homo sapiens_hsa047131.14634575
39Oocyte meiosis_Homo sapiens_hsa041141.13367715
40Nicotine addiction_Homo sapiens_hsa050331.13264782
41Cocaine addiction_Homo sapiens_hsa050301.13045280
42Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12727148
43Nitrogen metabolism_Homo sapiens_hsa009101.10248871
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10088000
45Renal cell carcinoma_Homo sapiens_hsa052111.09332953
46Basal transcription factors_Homo sapiens_hsa030221.06297648
47Base excision repair_Homo sapiens_hsa034101.04259723
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03196842
49Butanoate metabolism_Homo sapiens_hsa006501.02708287
50Adherens junction_Homo sapiens_hsa045201.02565221
51Ras signaling pathway_Homo sapiens_hsa040141.02502546
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02395119
53Oxidative phosphorylation_Homo sapiens_hsa001901.01225931
54Hedgehog signaling pathway_Homo sapiens_hsa043400.99973382
55Pyruvate metabolism_Homo sapiens_hsa006200.99133062
56Vitamin B6 metabolism_Homo sapiens_hsa007500.98461083
57Autoimmune thyroid disease_Homo sapiens_hsa053200.97287807
58Ovarian steroidogenesis_Homo sapiens_hsa049130.96891942
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96546250
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94397362
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.93221053
62Histidine metabolism_Homo sapiens_hsa003400.93025340
63Alzheimers disease_Homo sapiens_hsa050100.91535833
64Wnt signaling pathway_Homo sapiens_hsa043100.89996811
65Parkinsons disease_Homo sapiens_hsa050120.89808158
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.83453888
67Circadian rhythm_Homo sapiens_hsa047100.82736534
68Basal cell carcinoma_Homo sapiens_hsa052170.82469902
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.80947701
70Amphetamine addiction_Homo sapiens_hsa050310.80503131
71Tight junction_Homo sapiens_hsa045300.79190673
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77408999
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76229621
74Arginine and proline metabolism_Homo sapiens_hsa003300.75786884
75* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72450961
76Fatty acid metabolism_Homo sapiens_hsa012120.71855465
77Dopaminergic synapse_Homo sapiens_hsa047280.71612831
78Salivary secretion_Homo sapiens_hsa049700.70872594
79Endocytosis_Homo sapiens_hsa041440.70176819
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69800506
81Purine metabolism_Homo sapiens_hsa002300.69666678
82Renin secretion_Homo sapiens_hsa049240.69160384
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69152775
84Regulation of autophagy_Homo sapiens_hsa041400.68822481
85Primary immunodeficiency_Homo sapiens_hsa053400.67473886
86Cholinergic synapse_Homo sapiens_hsa047250.65266288
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64516035
88Biosynthesis of amino acids_Homo sapiens_hsa012300.64068067
89Melanogenesis_Homo sapiens_hsa049160.63727933
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63377078
91p53 signaling pathway_Homo sapiens_hsa041150.63149441
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62458814
93Rap1 signaling pathway_Homo sapiens_hsa040150.62450483
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61954989
95cAMP signaling pathway_Homo sapiens_hsa040240.61002686
96Dorso-ventral axis formation_Homo sapiens_hsa043200.60159182
97ECM-receptor interaction_Homo sapiens_hsa045120.58438121
98Gap junction_Homo sapiens_hsa045400.58252125
99Arachidonic acid metabolism_Homo sapiens_hsa005900.57819492
100Asthma_Homo sapiens_hsa053100.57732002
101Lysine degradation_Homo sapiens_hsa003100.56784826
102T cell receptor signaling pathway_Homo sapiens_hsa046600.56494080
103Malaria_Homo sapiens_hsa051440.56244390
104Olfactory transduction_Homo sapiens_hsa047400.55959073
105Alcoholism_Homo sapiens_hsa050340.55582321
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55321326
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55142091
108Carbon metabolism_Homo sapiens_hsa012000.53684645
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53634778
110Choline metabolism in cancer_Homo sapiens_hsa052310.52951318
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52858998
112One carbon pool by folate_Homo sapiens_hsa006700.52528696
113Proteasome_Homo sapiens_hsa030500.52362156
114ErbB signaling pathway_Homo sapiens_hsa040120.52265508
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51978469
116Vitamin digestion and absorption_Homo sapiens_hsa049770.51831588
117Long-term potentiation_Homo sapiens_hsa047200.51654947
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50029708
119Hippo signaling pathway_Homo sapiens_hsa043900.49836921
120Homologous recombination_Homo sapiens_hsa034400.49436508
121Calcium signaling pathway_Homo sapiens_hsa040200.48894119
122Taste transduction_Homo sapiens_hsa047420.48646506
123Folate biosynthesis_Homo sapiens_hsa007900.47621964
124Pathways in cancer_Homo sapiens_hsa052000.45257327
125Tryptophan metabolism_Homo sapiens_hsa003800.45070134
126Gastric acid secretion_Homo sapiens_hsa049710.44864055
127Pyrimidine metabolism_Homo sapiens_hsa002400.43824240
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43565520
129Phototransduction_Homo sapiens_hsa047440.43320936
130MicroRNAs in cancer_Homo sapiens_hsa052060.43312035
131Protein digestion and absorption_Homo sapiens_hsa049740.42830694
132Peroxisome_Homo sapiens_hsa041460.42003787
133Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41785410
134beta-Alanine metabolism_Homo sapiens_hsa004100.41411538
135Huntingtons disease_Homo sapiens_hsa050160.40975643
136Colorectal cancer_Homo sapiens_hsa052100.40314283
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.39691115
138Thyroid hormone synthesis_Homo sapiens_hsa049180.39476151
139Oxytocin signaling pathway_Homo sapiens_hsa049210.39035701
140* Metabolic pathways_Homo sapiens_hsa011000.38984425
141Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38339372
142Pancreatic secretion_Homo sapiens_hsa049720.37638219
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36799737
144Cardiac muscle contraction_Homo sapiens_hsa042600.35736419
145Mineral absorption_Homo sapiens_hsa049780.34957245
146Notch signaling pathway_Homo sapiens_hsa043300.33542419
147MAPK signaling pathway_Homo sapiens_hsa040100.32771549
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.32275539
149Nucleotide excision repair_Homo sapiens_hsa034200.31656099
150Chemokine signaling pathway_Homo sapiens_hsa040620.31334452
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31326255
152Allograft rejection_Homo sapiens_hsa053300.31072822
153TGF-beta signaling pathway_Homo sapiens_hsa043500.30292716

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