ST6GALNAC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.96588015
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.90938059
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.90938059
4protoporphyrinogen IX metabolic process (GO:0046501)4.85171375
5negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.80307766
6antigen processing and presentation of endogenous antigen (GO:0019883)4.50408687
7barbed-end actin filament capping (GO:0051016)4.40553144
8protoporphyrinogen IX biosynthetic process (GO:0006782)4.21617354
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06287013
10GDP-mannose metabolic process (GO:0019673)3.81231148
11heme biosynthetic process (GO:0006783)3.79972343
12regulation of B cell receptor signaling pathway (GO:0050855)3.79688446
13positive regulation of B cell differentiation (GO:0045579)3.77280160
14deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.59630136
15oxygen transport (GO:0015671)3.52776924
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51262675
17myeloid dendritic cell differentiation (GO:0043011)3.48606763
18porphyrin-containing compound biosynthetic process (GO:0006779)3.46252797
19defense response to protozoan (GO:0042832)3.44148722
20regulation of interleukin-12 biosynthetic process (GO:0045075)3.42703722
21myeloid dendritic cell activation (GO:0001773)3.42548525
22DNA deamination (GO:0045006)3.41860036
23Golgi transport vesicle coating (GO:0048200)3.41748160
24COPI coating of Golgi vesicle (GO:0048205)3.41748160
25regulation of gamma-delta T cell differentiation (GO:0045586)3.41277739
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.37070411
27regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.36447175
28negative regulation of phagocytosis (GO:0050765)3.35656430
29antigen processing and presentation via MHC class Ib (GO:0002475)3.35409997
30ribosomal small subunit assembly (GO:0000028)3.26984003
31response to protozoan (GO:0001562)3.25365477
32immunoglobulin mediated immune response (GO:0016064)3.24910954
33hemoglobin metabolic process (GO:0020027)3.24495379
34protein localization to endosome (GO:0036010)3.24229331
35regulation of gamma-delta T cell activation (GO:0046643)3.23893290
36positive regulation by symbiont of host defense response (GO:0052509)3.20335084
37modulation by symbiont of host defense response (GO:0052031)3.20335084
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.20335084
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.20335084
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.20335084
41modulation by symbiont of host immune response (GO:0052553)3.20335084
42response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.20007749
43response to host (GO:0075136)3.20007749
44response to host defenses (GO:0052200)3.20007749
45regulation of interferon-beta biosynthetic process (GO:0045357)3.18450591
46modulation by virus of host process (GO:0019054)3.14642543
47NIK/NF-kappaB signaling (GO:0038061)3.13578319
48positive regulation of interferon-alpha production (GO:0032727)3.12620565
49regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11083001
50heme metabolic process (GO:0042168)3.10215327
51modulation by symbiont of host cellular process (GO:0044068)3.08961401
52regulation of B cell differentiation (GO:0045577)3.08643692
53interferon-gamma-mediated signaling pathway (GO:0060333)3.04860118
54proline biosynthetic process (GO:0006561)3.03501955
55regulation of interferon-alpha production (GO:0032647)3.03198233
56response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02722304
57response to host immune response (GO:0052572)3.02722304
58negative regulation of interleukin-12 production (GO:0032695)3.00892945
59cellular response to arsenic-containing substance (GO:0071243)2.98713585
60pentose-phosphate shunt (GO:0006098)2.97905490
61B cell receptor signaling pathway (GO:0050853)2.94532624
62mannose metabolic process (GO:0006013)2.94019922
63negative regulation of necroptotic process (GO:0060546)2.91778372
64tetrapyrrole biosynthetic process (GO:0033014)2.87425937
65endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.87076142
66dendritic cell differentiation (GO:0097028)2.86969251
673-UTR-mediated mRNA stabilization (GO:0070935)2.86900799
68porphyrin-containing compound metabolic process (GO:0006778)2.85973151
69gas transport (GO:0015669)2.85919213
70protein maturation by protein folding (GO:0022417)2.85838115
71mitochondrial calcium ion transport (GO:0006851)2.85540793
72type I interferon signaling pathway (GO:0060337)2.84192693
73cellular response to type I interferon (GO:0071357)2.84192693
74macrophage activation involved in immune response (GO:0002281)2.82459189
75chaperone mediated protein folding requiring cofactor (GO:0051085)2.81577415
76positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.80045824
77response to type I interferon (GO:0034340)2.79915549
78neutrophil mediated immunity (GO:0002446)2.79615140
79respiratory burst (GO:0045730)2.78139022
80negative regulation of granulocyte differentiation (GO:0030853)2.77431788
81apoptotic process involved in morphogenesis (GO:0060561)2.76416558
82positive regulation of natural killer cell differentiation (GO:0032825)2.75508621
83cellular response to zinc ion (GO:0071294)2.72415922
84glycosphingolipid catabolic process (GO:0046479)2.71561939
85response to peptidoglycan (GO:0032494)2.70584167
86amyloid precursor protein catabolic process (GO:0042987)2.69429969
87neutrophil activation involved in immune response (GO:0002283)2.69257473
88positive regulation of Cdc42 GTPase activity (GO:0043089)2.67777873
89cellular response to virus (GO:0098586)2.67735290
90response to muramyl dipeptide (GO:0032495)2.67680572
91cellular response to interferon-beta (GO:0035458)2.66696135
92IMP biosynthetic process (GO:0006188)2.65326392
93amino sugar catabolic process (GO:0046348)2.65133016
94positive regulation of antigen processing and presentation (GO:0002579)2.64174926
95positive regulation of isotype switching (GO:0045830)2.63968014
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.63067615
97regulation of response to osmotic stress (GO:0047484)2.60450913
98regulation of type I interferon-mediated signaling pathway (GO:0060338)2.59924909
99actin nucleation (GO:0045010)2.58804001
100mast cell activation (GO:0045576)2.57947007
101B cell mediated immunity (GO:0019724)2.56680924
102pentose metabolic process (GO:0019321)2.56495387
103mitochondrial fusion (GO:0008053)2.56114064
104maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54947519
105T cell homeostasis (GO:0043029)2.54649475
106positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53693767
107JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.52014788
108G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.50272444
109positive regulation of interferon-beta production (GO:0032728)2.49962009
110NADPH regeneration (GO:0006740)2.49033866
111pyrimidine-containing compound salvage (GO:0008655)2.48115605
112pyrimidine nucleoside salvage (GO:0043097)2.48115605
113leukocyte aggregation (GO:0070486)2.47780141
114glycolipid catabolic process (GO:0019377)2.47559612
115regulation of mast cell degranulation (GO:0043304)2.46635202
116negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.45974742
117detection of bacterium (GO:0016045)2.45292613
118IMP metabolic process (GO:0046040)2.45260853
119regulation of response to interferon-gamma (GO:0060330)2.44972513
120protein retention in ER lumen (GO:0006621)2.44609664
121nucleobase-containing small molecule interconversion (GO:0015949)2.43751741
122sodium ion export (GO:0071436)2.42767521
123oligosaccharide catabolic process (GO:0009313)2.42384565
124regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.42292289
125regulation of protein heterodimerization activity (GO:0043497)2.42004805
126negative regulation of protein localization to plasma membrane (GO:1903077)2.41738459
127positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.41602330
128myeloid leukocyte mediated immunity (GO:0002444)2.41436205
129positive regulation of B cell mediated immunity (GO:0002714)2.41267770
130positive regulation of immunoglobulin mediated immune response (GO:0002891)2.41267770
131response to interleukin-15 (GO:0070672)2.40903357
132positive regulation of fibroblast migration (GO:0010763)2.40328515
133response to interferon-alpha (GO:0035455)2.39904084
134germinal center formation (GO:0002467)2.39541361
135modulation of growth of symbiont involved in interaction with host (GO:0044144)2.38448093
136regulation of growth of symbiont in host (GO:0044126)2.38448093
137negative regulation of growth of symbiont in host (GO:0044130)2.38448093
138negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.38448093
139regulation of necroptotic process (GO:0060544)2.37554990
140negative regulation of erythrocyte differentiation (GO:0045647)2.37303490
141pinocytosis (GO:0006907)2.37080183
142negative regulation of viral release from host cell (GO:1902187)2.36891118
143T cell migration (GO:0072678)2.36777613
144regulation of T cell receptor signaling pathway (GO:0050856)2.36345533
145endosome to melanosome transport (GO:0035646)2.36143319
146endosome to pigment granule transport (GO:0043485)2.36143319
147myeloid cell activation involved in immune response (GO:0002275)2.35976826
148response to interferon-beta (GO:0035456)2.35799986
149positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.35156385
150regulation of necrotic cell death (GO:0010939)2.35042788
151glucose catabolic process (GO:0006007)2.34894006
152detection of other organism (GO:0098543)2.34556280
153positive regulation of extracellular matrix organization (GO:1903055)2.34171947
154lipopolysaccharide-mediated signaling pathway (GO:0031663)2.33386700
155regulation of actin cytoskeleton reorganization (GO:2000249)2.33208426
156CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.33007330
157T cell apoptotic process (GO:0070231)2.32702319
158cellular response to interferon-gamma (GO:0071346)2.32607255
159UV protection (GO:0009650)2.32225195
160lymphocyte homeostasis (GO:0002260)2.32212354
161activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31783863
162negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.31700198
163negative regulation of cell killing (GO:0031342)2.31700198
164positive regulation of protein homooligomerization (GO:0032464)2.31622576
165regulation of mammary gland epithelial cell proliferation (GO:0033599)2.31173741
166stress fiber assembly (GO:0043149)2.30886481
167regulation of superoxide anion generation (GO:0032928)2.30750555
168regulation of early endosome to late endosome transport (GO:2000641)2.29624586
169glucose 6-phosphate metabolic process (GO:0051156)2.28929427
170erythrocyte maturation (GO:0043249)2.28049377

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.47848360
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.74193219
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.52321577
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39141315
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.36591374
6MYC_22102868_ChIP-Seq_BL_Human3.12878069
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.09647120
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.99572365
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.74935716
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.74712996
11VDR_21846776_ChIP-Seq_THP-1_Human2.72693638
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69510093
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.62985889
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.55845238
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54854723
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.37598777
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27146530
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.25799383
19SCL_19346495_ChIP-Seq_HPC-7_Human2.24668414
20* SPI1_23547873_ChIP-Seq_NB4_Human2.23458456
21* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.23308846
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19569074
23* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19479917
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.18322928
25* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16449018
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.11161919
27VDR_24763502_ChIP-Seq_THP-1_Human2.08756739
28TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08671489
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.06082539
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04482280
31MAF_26560356_Chip-Seq_TH1_Human1.97660456
32SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.93218075
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82282186
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79101394
35MYB_26560356_Chip-Seq_TH2_Human1.78041333
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75876430
37SPI1_23127762_ChIP-Seq_K562_Human1.75602787
38UTX_26944678_Chip-Seq_JUKART_Human1.74898984
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74046586
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.73439013
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72321660
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71395613
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70275109
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70010105
45CIITA_25753668_ChIP-Seq_RAJI_Human1.69540573
46TCF7_22412390_ChIP-Seq_EML_Mouse1.68333795
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66292904
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66045513
49RUNX_20019798_ChIP-Seq_JUKART_Human1.64565683
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63360487
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61907004
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61658638
53MYB_26560356_Chip-Seq_TH1_Human1.60763146
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.60443195
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.59411091
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54662315
57VDR_23849224_ChIP-Seq_CD4+_Human1.53957173
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.51052321
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50320457
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48938907
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44709007
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.44535367
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42858194
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.41840421
65GATA1_22025678_ChIP-Seq_K562_Human1.40953431
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40935493
67ZNF263_19887448_ChIP-Seq_K562_Human1.40455861
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39680973
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.39633515
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.39606132
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.39267151
72XRN2_22483619_ChIP-Seq_HELA_Human1.39169579
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.37333511
74* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36939549
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.35065353
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34406798
77GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33766109
78* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32934934
79NCOR1_26117541_ChIP-Seq_K562_Human1.31866666
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31664312
81MAF_26560356_Chip-Seq_TH2_Human1.31317639
82P68_20966046_ChIP-Seq_HELA_Human1.31155504
83DCP1A_22483619_ChIP-Seq_HELA_Human1.29534933
84KDM2B_26808549_Chip-Seq_DND41_Human1.28118211
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27009467
86FOXP3_21729870_ChIP-Seq_TREG_Human1.26991930
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25206136
88TP63_17297297_ChIP-ChIP_HaCaT_Human1.24712135
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.24456338
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24413426
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23821049
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22825791
93TFEB_21752829_ChIP-Seq_HELA_Human1.20953303
94* BCL6_27268052_Chip-Seq_Bcells_Human1.20209557
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19643149
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18227021
97PU_27001747_Chip-Seq_BMDM_Mouse1.17801859
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17346574
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17307632
100* BCOR_27268052_Chip-Seq_Bcells_Human1.17009258
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16481172
102* ATF3_27146783_Chip-Seq_COLON_Human1.15052582
103GATA1_19941826_ChIP-Seq_K562_Human1.14775601
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.13855236
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13488051
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13414277
107* LXR_22292898_ChIP-Seq_THP-1_Human1.13410153
108GABP_19822575_ChIP-Seq_HepG2_Human1.12617804
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12076595
110FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12024704
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11886675
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11726986
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10289166
114ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10216068
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09893745
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09788007
117CTCF_21964334_Chip-Seq_Bcells_Human1.09749174
118* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09119489
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08996697
120* GATA3_27048872_Chip-Seq_THYMUS_Human1.08664811
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07335448
122UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06848793
123CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06583901
124GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06022151
125* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05541734
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.04237755
127SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03397050
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02966107
129GATA1_19941827_ChIP-Seq_MEL_Mouse1.02869919
130PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02243359
131STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02121588
132FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01478925
133FOXM1_23109430_ChIP-Seq_U2OS_Human0.99951332
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99915803
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99575651
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99256893
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96698034
138CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94289849
139* SRF_21415370_ChIP-Seq_HL-1_Mouse0.93904263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.81316774
2MP0005451_abnormal_body_composition3.48340489
3MP0003303_peritoneal_inflammation3.17680010
4MP0005671_abnormal_response_to3.16504731
5MP0002396_abnormal_hematopoietic_system2.80824598
6MP0003656_abnormal_erythrocyte_physiolo2.77714762
7MP0003436_decreased_susceptibility_to2.75978836
8MP0003705_abnormal_hypodermis_morpholog2.62052049
9MP0001800_abnormal_humoral_immune2.50572914
10MP0002452_abnormal_antigen_presenting2.43423582
11MP0005000_abnormal_immune_tolerance2.42758962
12MP0009785_altered_susceptibility_to2.41904202
13MP0008260_abnormal_autophagy2.41350533
14MP0000685_abnormal_immune_system2.37247319
15MP0004510_myositis2.36072556
16MP0003763_abnormal_thymus_physiology2.35466846
17MP0002148_abnormal_hypersensitivity_rea2.33367477
18MP0009333_abnormal_splenocyte_physiolog2.31793238
19MP0002419_abnormal_innate_immunity2.30080791
20MP0002723_abnormal_immune_serum2.29455053
21MP0002420_abnormal_adaptive_immunity2.28242055
22MP0001819_abnormal_immune_cell2.26371677
23MP0005025_abnormal_response_to2.25062308
24MP0008438_abnormal_cutaneous_collagen2.22007320
25MP0003172_abnormal_lysosome_physiology2.21331791
26MP0005464_abnormal_platelet_physiology2.17255401
27MP0005387_immune_system_phenotype2.16351562
28MP0001790_abnormal_immune_system2.16351562
29MP0002398_abnormal_bone_marrow2.09713563
30MP0005058_abnormal_lysosome_morphology2.05992346
31MP0002405_respiratory_system_inflammati2.05215354
32MP0006082_CNS_inflammation1.98074734
33MP0001873_stomach_inflammation1.95515906
34MP0004782_abnormal_surfactant_physiolog1.87408410
35MP0001853_heart_inflammation1.86689156
36MP0000716_abnormal_immune_system1.86345150
37MP0003950_abnormal_plasma_membrane1.85468041
38MP0004808_abnormal_hematopoietic_stem1.82012842
39MP0003300_gastrointestinal_ulcer1.81863029
40MP0000689_abnormal_spleen_morphology1.81808069
41MP0002722_abnormal_immune_system1.75933721
42MP0002166_altered_tumor_susceptibility1.71785950
43MP0003566_abnormal_cell_adhesion1.68966943
44MP0002429_abnormal_blood_cell1.68072202
45MP0002877_abnormal_melanocyte_morpholog1.66913829
46MP0005083_abnormal_biliary_tract1.66358634
47MP0008007_abnormal_cellular_replicative1.64790514
48MP0001545_abnormal_hematopoietic_system1.60492972
49MP0005397_hematopoietic_system_phenotyp1.60492972
50MP0003279_aneurysm1.57767340
51MP0003724_increased_susceptibility_to1.54816789
52MP0000703_abnormal_thymus_morphology1.52028795
53MP0003866_abnormal_defecation1.50946096
54MP0000858_altered_metastatic_potential1.50547755
55MP0000465_gastrointestinal_hemorrhage1.50152395
56MP0004084_abnormal_cardiac_muscle1.49829709
57MP0001845_abnormal_inflammatory_respons1.46297514
58MP0010155_abnormal_intestine_physiology1.44086524
59MP0001533_abnormal_skeleton_physiology1.42950530
60MP0000490_abnormal_crypts_of1.41807624
61MP0003693_abnormal_embryo_hatching1.40000613
62MP0010352_gastrointestinal_tract_polyps1.38685790
63MP0009840_abnormal_foam_cell1.37517211
64MP0002006_tumorigenesis1.36147211
65MP0001849_ear_inflammation1.34794417
66MP0003453_abnormal_keratinocyte_physiol1.29376047
67MP0002132_abnormal_respiratory_system1.28205545
68MP0003075_altered_response_to1.26254213
69MP0003806_abnormal_nucleotide_metabolis1.25291121
70MP0003448_altered_tumor_morphology1.24395369
71MP0006054_spinal_hemorrhage1.21844478
72MP0000678_abnormal_parathyroid_gland1.21425687
73MP0003091_abnormal_cell_migration1.20339701
74MP0010307_abnormal_tumor_latency1.18144669
75MP0004147_increased_porphyrin_level1.11224543
76MP0005501_abnormal_skin_physiology1.11119298
77MP0001661_extended_life_span1.10478838
78MP0008469_abnormal_protein_level1.09839512
79MP0000343_altered_response_to1.08713187
80MP0002933_joint_inflammation1.08627939
81MP0003186_abnormal_redox_activity1.07703047
82MP0004947_skin_inflammation1.06920909
83MP0005076_abnormal_cell_differentiation1.04318705
84MP0004185_abnormal_adipocyte_glucose1.01433247
85MP0003077_abnormal_cell_cycle1.01376272
86MP0009278_abnormal_bone_marrow1.00115368
87MP0002090_abnormal_vision0.99541289
88MP0003111_abnormal_nucleus_morphology0.95871494
89MP0008057_abnormal_DNA_replication0.95339526
90MP0002019_abnormal_tumor_incidence0.91535916
91MP0002998_abnormal_bone_remodeling0.91065148
92MP0000733_abnormal_muscle_development0.90958134
93MP0003828_pulmonary_edema0.89278000
94MP0004233_abnormal_muscle_weight0.87654188
95MP0005165_increased_susceptibility_to0.87089180
96MP0003221_abnormal_cardiomyocyte_apopto0.86784203
97MP0000313_abnormal_cell_death0.85427726
98MP0009931_abnormal_skin_appearance0.85062502
99MP0000767_abnormal_smooth_muscle0.84685807
100MP0000604_amyloidosis0.84109875
101MP0005621_abnormal_cell_physiology0.81790952
102MP0000759_abnormal_skeletal_muscle0.80995974
103MP0001851_eye_inflammation0.80925578
104MP0006036_abnormal_mitochondrial_physio0.79916712
105MP0003191_abnormal_cellular_cholesterol0.79597412
106MP0005166_decreased_susceptibility_to0.78783967
107MP0001958_emphysema0.78746364
108MP0010094_abnormal_chromosome_stability0.77484039
109MP0005330_cardiomyopathy0.77181092
110MP0000750_abnormal_muscle_regeneration0.76487295
111MP0004858_abnormal_nervous_system0.76338771
112MP0001663_abnormal_digestive_system0.74914623
113MP0008874_decreased_physiological_sensi0.74659885
114MP0005310_abnormal_salivary_gland0.74141595
115MP0004145_abnormal_muscle_electrophysio0.73091030
116MP0005623_abnormal_meninges_morphology0.71798985
117MP0009764_decreased_sensitivity_to0.70891229
118MP0001348_abnormal_lacrimal_gland0.70418939
119MP0000749_muscle_degeneration0.70171844
120MP0001730_embryonic_growth_arrest0.69154732
121MP0003786_premature_aging0.69024969
122MP0004036_abnormal_muscle_relaxation0.67437453
123MP0004957_abnormal_blastocyst_morpholog0.67017273
124MP0008058_abnormal_DNA_repair0.65850458
125MP0003795_abnormal_bone_structure0.65444554
126MP0000015_abnormal_ear_pigmentation0.65407239
127MP0004215_abnormal_myocardial_fiber0.65053977
128MP0000358_abnormal_cell_content/0.63808532
129MP0005023_abnormal_wound_healing0.63215060
130MP0000249_abnormal_blood_vessel0.62812260
131MP0002089_abnormal_postnatal_growth/wei0.62155224
132MP0000350_abnormal_cell_proliferation0.61696651
133MP0008775_abnormal_heart_ventricle0.58234053
134MP0003943_abnormal_hepatobiliary_system0.57872294
135MP0002083_premature_death0.56820227

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.36210689
2Abnormality of the heme biosynthetic pathway (HP:0010472)4.01372685
3Eczematoid dermatitis (HP:0000976)3.99854156
4Recurrent abscess formation (HP:0002722)3.97827159
5Increased cerebral lipofuscin (HP:0011813)3.57678383
6Recurrent bacterial skin infections (HP:0005406)3.39801913
7Thrombocytosis (HP:0001894)3.38311901
8Myositis (HP:0100614)3.37440943
9Congenital stationary night blindness (HP:0007642)3.36487631
10Chronic otitis media (HP:0000389)3.35488586
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.26906113
12Recurrent viral infections (HP:0004429)3.23758834
13Ileus (HP:0002595)3.23217555
14Cholelithiasis (HP:0001081)3.19887219
15Vertebral compression fractures (HP:0002953)3.19610086
16Hypochromic microcytic anemia (HP:0004840)3.18177751
17Mediastinal lymphadenopathy (HP:0100721)3.18116209
18Recurrent fungal infections (HP:0002841)3.16210671
19Abnormality of liposaccharide metabolism (HP:0010968)3.11731717
20Abnormality of glycosphingolipid metabolism (HP:0004343)3.11731717
21Abnormality of glycolipid metabolism (HP:0010969)3.11731717
22Polycythemia (HP:0001901)3.08954350
23Abnormality of macrophages (HP:0004311)3.07979077
24Hypertensive crisis (HP:0100735)3.05251164
25IgM deficiency (HP:0002850)2.98673519
26Abnormal gallbladder physiology (HP:0012438)2.91891471
27Cholecystitis (HP:0001082)2.91891471
28Panhypogammaglobulinemia (HP:0003139)2.91054377
29Interstitial pulmonary disease (HP:0006530)2.90929487
30Dysostosis multiplex (HP:0000943)2.82196010
31Abnormal gallbladder morphology (HP:0012437)2.72430657
32Agammaglobulinemia (HP:0004432)2.72297841
33Reticulocytosis (HP:0001923)2.71940783
34Albinism (HP:0001022)2.71909541
35Obstructive lung disease (HP:0006536)2.67343700
36Chronic obstructive pulmonary disease (HP:0006510)2.67343700
37Vacuolated lymphocytes (HP:0001922)2.64118691
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.59036684
39Basal ganglia calcification (HP:0002135)2.55669874
40Abnormality of T cell physiology (HP:0011840)2.54142284
41Fatigue (HP:0012378)2.53590430
42Chronic mucocutaneous candidiasis (HP:0002728)2.52791728
43Recurrent cutaneous fungal infections (HP:0011370)2.52791728
44Cellulitis (HP:0100658)2.52108345
45Hypochromic anemia (HP:0001931)2.50706694
46Petechiae (HP:0000967)2.46512905
47Gastrointestinal inflammation (HP:0004386)2.42138265
48Abnormality of the sella turcica (HP:0002679)2.42109658
49Chest pain (HP:0100749)2.39008568
50Urticaria (HP:0001025)2.38549206
51J-shaped sella turcica (HP:0002680)2.37654059
52Microcytic anemia (HP:0001935)2.36552590
53Spontaneous hematomas (HP:0007420)2.35974464
54Abnormality of the gallbladder (HP:0005264)2.34693302
55Abnormal rod and cone electroretinograms (HP:0008323)2.34544476
56Recurrent bronchitis (HP:0002837)2.34437701
57Recurrent skin infections (HP:0001581)2.33144065
58Joint stiffness (HP:0001387)2.32899207
59Inflammation of the large intestine (HP:0002037)2.31527703
60Protrusio acetabuli (HP:0003179)2.31326995
61Loss of speech (HP:0002371)2.31066374
62Colitis (HP:0002583)2.29997839
63Abnormal platelet function (HP:0011869)2.29006752
64Impaired platelet aggregation (HP:0003540)2.29006752
65Centrally nucleated skeletal muscle fibers (HP:0003687)2.29006082
66Entropion (HP:0000621)2.27800525
67Poikiloderma (HP:0001029)2.26664408
68Distal lower limb muscle weakness (HP:0009053)2.26579777
69Gastrointestinal dysmotility (HP:0002579)2.25701119
70Abnormality of T cells (HP:0002843)2.25481555
71Abnormality of skeletal muscle fiber size (HP:0012084)2.23131320
72Ragged-red muscle fibers (HP:0003200)2.22920461
73Granulocytopenia (HP:0001913)2.22868145
74Meningitis (HP:0001287)2.22735075
75Spinal rigidity (HP:0003306)2.22497559
76Stomatitis (HP:0010280)2.22356372
77Gastrointestinal infarctions (HP:0005244)2.20853756
78Poor head control (HP:0002421)2.20666535
79Myopathic facies (HP:0002058)2.20277317
80Orchitis (HP:0100796)2.19677284
81Abnormal hemoglobin (HP:0011902)2.17779825
82Mucopolysacchariduria (HP:0008155)2.16109074
83Urinary glycosaminoglycan excretion (HP:0003541)2.16109074
84Severe visual impairment (HP:0001141)2.15092551
85Eosinophilia (HP:0001880)2.14614887
86Increased variability in muscle fiber diameter (HP:0003557)2.14338058
87Vasculitis (HP:0002633)2.13979538
88Emphysema (HP:0002097)2.13944087
89Mutism (HP:0002300)2.13096727
90Viral hepatitis (HP:0006562)2.12936544
91Abnormality of the nasal mucosa (HP:0000433)2.12300263
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11491863
93Abnormality of B cell number (HP:0010975)2.10855802
94B lymphocytopenia (HP:0010976)2.10855802
95Nonimmune hydrops fetalis (HP:0001790)2.10044270
96Increased connective tissue (HP:0009025)2.09152010
97Arterial thrombosis (HP:0004420)2.08175880
98Increased serum ferritin (HP:0003281)2.04161861
99Arterial tortuosity (HP:0005116)2.03589052
100Muscle stiffness (HP:0003552)2.03434047
101Bulbar palsy (HP:0001283)2.02195445
102Cerebral aneurysm (HP:0004944)2.01777259
103Diminished motivation (HP:0000745)2.01585882
104Lymphoma (HP:0002665)2.01516543
105Broad face (HP:0000283)2.01496231
106Abnormality of polysaccharide metabolism (HP:0011012)2.01226135
107Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01226135
108Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01226135
109Leukocytosis (HP:0001974)2.01027862
110Premature rupture of membranes (HP:0001788)2.00806585
111Abnormality of reticulocytes (HP:0004312)1.99218564
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98795356
113Hypertriglyceridemia (HP:0002155)1.97503170
114Nasal polyposis (HP:0100582)1.97205359
115Hemoptysis (HP:0002105)1.97051628
116Progressive muscle weakness (HP:0003323)1.96098981
117IgA deficiency (HP:0002720)1.95282127
118Lymphopenia (HP:0001888)1.95262990
119Increased density of long bones (HP:0006392)1.94841502
120Verrucae (HP:0200043)1.94754035
121Papilloma (HP:0012740)1.94754035
122Abnormal number of erythroid precursors (HP:0012131)1.94458535
123Spinal cord lesions (HP:0100561)1.93208171
124Syringomyelia (HP:0003396)1.93208171
125Purpura (HP:0000979)1.92666938
126Hepatosplenomegaly (HP:0001433)1.92397027
127Abnormality of cells of the lymphoid lineage (HP:0012140)1.92231827
128Pulmonary infiltrates (HP:0002113)1.92123682
129Amaurosis fugax (HP:0100576)1.89983883
130Recurrent lower respiratory tract infections (HP:0002783)1.89420961
131Deformed sella turcica (HP:0002681)1.89291964
132Gingivitis (HP:0000230)1.89242302
133Gastrointestinal stroma tumor (HP:0100723)1.88871898
134Spondylolisthesis (HP:0003302)1.88692759
135Recurrent gram-negative bacterial infections (HP:0005420)1.88078327
136Reduced subcutaneous adipose tissue (HP:0003758)1.87926567
137Aortic aneurysm (HP:0004942)1.87834930
138Agnosia (HP:0010524)1.85892293
139Systemic lupus erythematosus (HP:0002725)1.84615359
140Upper motor neuron abnormality (HP:0002127)1.84512536
141Polygenic inheritance (HP:0010982)1.84087753
142Abnormality of cells of the erythroid lineage (HP:0012130)1.83884319
143Increased IgE level (HP:0003212)1.83452957
144Epistaxis (HP:0000421)1.83073092
145Apathy (HP:0000741)1.81903412
146Neoplasm of head and neck (HP:0012288)1.81630490
147Esophageal neoplasm (HP:0100751)1.81630490
148Optic neuritis (HP:0100653)1.81430079
149Retrobulbar optic neuritis (HP:0100654)1.81430079
150Osteomyelitis (HP:0002754)1.81365667
151Achilles tendon contracture (HP:0001771)1.81338918
152Paralysis (HP:0003470)1.78161359
153Distal lower limb amyotrophy (HP:0008944)1.78063240
154Cervical subluxation (HP:0003308)1.77755840
155Myocardial infarction (HP:0001658)1.77477569
156Poikilocytosis (HP:0004447)1.77470326
157Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.76841754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.13514342
2SMG13.95021487
3TGFBR23.05278305
4VRK22.96883224
5PIM22.96003763
6BLK2.74483881
7TBK12.39225749
8NME22.38865981
9KIT2.36966273
10ZAP702.33904758
11JAK32.32892687
12EEF2K2.32353013
13ERN12.30502417
14PKN22.21587547
15TAOK22.20745778
16TYK22.14906866
17TRIB32.02406219
18TXK1.87809275
19IRAK31.80606997
20RIPK41.77093266
21MAP2K31.75120132
22SCYL21.73142232
23CLK11.60407859
24BTK1.58415321
25CSF1R1.58176568
26ICK1.55523370
27SIK11.54431691
28KDR1.53995084
29MAP3K141.51444794
30TEC1.49570184
31IKBKB1.47141091
32TSSK61.46822641
33STK101.43273807
34MAP3K111.42048152
35SYK1.41567582
36FES1.41525886
37TAF11.35183240
38RPS6KA41.32197094
39TESK21.31345376
40CAMKK21.30078634
41IRAK41.23576173
42IKBKE1.22343654
43LRRK21.22218214
44HCK1.17667871
45NEK11.13119715
46RAF11.12741055
47MAP3K101.12702353
48EPHB11.08887553
49MAPK111.08403791
50FLT31.06740894
51PRKD21.02051162
52LYN1.01597529
53JAK11.00879099
54LCK1.00869803
55TGFBR10.97544258
56IRAK20.95737526
57MOS0.95458831
58TESK10.93084641
59EIF2AK30.91982753
60BMX0.90616279
61MAP3K50.89371496
62ITK0.89220930
63PIM10.88938594
64TTN0.88712459
65ABL20.85089215
66PAK40.84848026
67RPS6KB20.82410471
68PRKD30.81725041
69CHUK0.79731969
70MAPKAPK30.79563876
71PAK20.77594551
72PRKG20.77280356
73CSK0.76417369
74MAP3K80.75859161
75CDK80.73254372
76ARAF0.72595869
77CDC42BPA0.72155258
78SIK30.71104364
79KSR20.70964876
80STK40.69848240
81ILK0.68265002
82DDR20.67925835
83BRAF0.67525950
84JAK20.64450919
85GRK70.63916039
86PDGFRA0.63905932
87MAP3K130.63859973
88BCKDK0.61087768
89PTK20.60591929
90WEE10.59739791
91STK160.58403966
92DAPK10.57943064
93MELK0.57941135
94RIPK10.57391137
95PDPK10.57269100
96CAMKK10.57026516
97MARK20.56886116
98FGFR40.56640755
99FGR0.56532335
100MATK0.56395930
101DAPK30.55404790
102BUB10.54662361
103NME10.53555843
104CDK90.53270783
105TAOK10.52774727
106CDK40.51031417
107CDK70.48633464
108HIPK20.47863624
109MAP3K30.47578475
110SIK20.46763981
111MAPKAPK20.46223282
112TIE10.46129937
113RPS6KA60.45088448
114RPS6KA20.44780079
115MTOR0.43381073
116NEK20.43197595
117EPHA20.42986952
118ATR0.41000458
119MARK30.40353088
120MAP2K20.40218257
121VRK10.39936960
122PTK2B0.39875053
123ALK0.39358464
124RPS6KC10.39300301
125RPS6KL10.39300301
126MAPK120.38169917
127EIF2AK20.38158503
128EIF2AK10.37291000
129GRK60.36982537
130PAK10.35058768
131PTK60.34556456
132ABL10.33704724
133NEK90.33305479
134TNK20.31818277
135MAP3K70.31272314
136MAP3K10.31204304
137PRPF4B0.30755393
138STK240.29654193
139FGFR30.28963152
140EGFR0.28282794

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.82769008
2Sulfur relay system_Homo sapiens_hsa041222.18747259
3Leishmaniasis_Homo sapiens_hsa051402.15922259
4Primary immunodeficiency_Homo sapiens_hsa053401.95856872
5DNA replication_Homo sapiens_hsa030301.95108428
6B cell receptor signaling pathway_Homo sapiens_hsa046621.89503523
7* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.85921681
8Osteoclast differentiation_Homo sapiens_hsa043801.77439888
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.74631520
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.72823477
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71743421
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.71351844
13Antigen processing and presentation_Homo sapiens_hsa046121.70097801
14Measles_Homo sapiens_hsa051621.69457168
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66279782
16Bladder cancer_Homo sapiens_hsa052191.59170187
17Legionellosis_Homo sapiens_hsa051341.59118393
18Other glycan degradation_Homo sapiens_hsa005111.55891692
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54259408
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53087787
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49485824
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44779858
23Lysosome_Homo sapiens_hsa041421.42334741
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41335358
25Ribosome_Homo sapiens_hsa030101.39225591
26Proteasome_Homo sapiens_hsa030501.37665557
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36835833
28Shigellosis_Homo sapiens_hsa051311.35169137
29Allograft rejection_Homo sapiens_hsa053301.31988217
30Herpes simplex infection_Homo sapiens_hsa051681.29071165
31Tuberculosis_Homo sapiens_hsa051521.26232808
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26097241
33Toxoplasmosis_Homo sapiens_hsa051451.24927315
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23933957
35Acute myeloid leukemia_Homo sapiens_hsa052211.22374662
36Hepatitis B_Homo sapiens_hsa051611.22350221
37Base excision repair_Homo sapiens_hsa034101.21513702
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21263206
39T cell receptor signaling pathway_Homo sapiens_hsa046601.20520207
40Apoptosis_Homo sapiens_hsa042101.20473947
41Influenza A_Homo sapiens_hsa051641.17841386
42Pertussis_Homo sapiens_hsa051331.17372092
43Chronic myeloid leukemia_Homo sapiens_hsa052201.16518855
44Viral myocarditis_Homo sapiens_hsa054161.15791376
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15762406
46Biosynthesis of amino acids_Homo sapiens_hsa012301.13849599
47N-Glycan biosynthesis_Homo sapiens_hsa005101.13103310
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11957804
49Epstein-Barr virus infection_Homo sapiens_hsa051691.11568267
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09953473
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.08372320
52Hematopoietic cell lineage_Homo sapiens_hsa046401.08136516
53Malaria_Homo sapiens_hsa051441.07358688
54Spliceosome_Homo sapiens_hsa030401.05844431
55TNF signaling pathway_Homo sapiens_hsa046681.05061064
56Salmonella infection_Homo sapiens_hsa051321.04399400
57Graft-versus-host disease_Homo sapiens_hsa053321.00614802
58Chemokine signaling pathway_Homo sapiens_hsa040621.00261163
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.99718039
60Autoimmune thyroid disease_Homo sapiens_hsa053200.95582780
61Notch signaling pathway_Homo sapiens_hsa043300.94066447
62One carbon pool by folate_Homo sapiens_hsa006700.93662643
63Vibrio cholerae infection_Homo sapiens_hsa051100.93391743
64HIF-1 signaling pathway_Homo sapiens_hsa040660.92635275
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90425091
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90098796
67Carbon metabolism_Homo sapiens_hsa012000.89685666
68Type I diabetes mellitus_Homo sapiens_hsa049400.88135626
69Pancreatic cancer_Homo sapiens_hsa052120.85229103
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.85043229
71Asthma_Homo sapiens_hsa053100.84364237
72Mismatch repair_Homo sapiens_hsa034300.84046097
73HTLV-I infection_Homo sapiens_hsa051660.83572290
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83468821
75Pentose phosphate pathway_Homo sapiens_hsa000300.83077272
76Platelet activation_Homo sapiens_hsa046110.82419205
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81546102
78Non-homologous end-joining_Homo sapiens_hsa034500.81480425
79Viral carcinogenesis_Homo sapiens_hsa052030.81320475
80RNA transport_Homo sapiens_hsa030130.77516032
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.75330503
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73482677
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.70697111
84Pyrimidine metabolism_Homo sapiens_hsa002400.70575632
85Staphylococcus aureus infection_Homo sapiens_hsa051500.70386283
86RNA polymerase_Homo sapiens_hsa030200.70194629
87Thyroid cancer_Homo sapiens_hsa052160.70167950
88Sulfur metabolism_Homo sapiens_hsa009200.69289233
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.67156048
90VEGF signaling pathway_Homo sapiens_hsa043700.66012089
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65508797
92Colorectal cancer_Homo sapiens_hsa052100.64866958
93Endometrial cancer_Homo sapiens_hsa052130.63985296
94Nucleotide excision repair_Homo sapiens_hsa034200.62637258
95Rheumatoid arthritis_Homo sapiens_hsa053230.60940720
96Renal cell carcinoma_Homo sapiens_hsa052110.59814120
97Proteoglycans in cancer_Homo sapiens_hsa052050.59775682
98Insulin signaling pathway_Homo sapiens_hsa049100.59425632
99Pancreatic secretion_Homo sapiens_hsa049720.58989762
100Glutathione metabolism_Homo sapiens_hsa004800.58144804
101Non-small cell lung cancer_Homo sapiens_hsa052230.57742513
102Prion diseases_Homo sapiens_hsa050200.57232209
103Phagosome_Homo sapiens_hsa041450.57141851
104Galactose metabolism_Homo sapiens_hsa000520.56967228
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56468104
106mTOR signaling pathway_Homo sapiens_hsa041500.56369049
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55288411
108Prolactin signaling pathway_Homo sapiens_hsa049170.53681228
109Glioma_Homo sapiens_hsa052140.53217313
110p53 signaling pathway_Homo sapiens_hsa041150.53157027
111Systemic lupus erythematosus_Homo sapiens_hsa053220.52701214
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50938444
113Small cell lung cancer_Homo sapiens_hsa052220.50430539
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49966057
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.49949466
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49603968
117RNA degradation_Homo sapiens_hsa030180.49078961
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48109865
119Dilated cardiomyopathy_Homo sapiens_hsa054140.47971342
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47133945
121Fructose and mannose metabolism_Homo sapiens_hsa000510.46884481
122Cell cycle_Homo sapiens_hsa041100.46763667
123Homologous recombination_Homo sapiens_hsa034400.46145334
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45888069
125Endocytosis_Homo sapiens_hsa041440.45140586
126Hepatitis C_Homo sapiens_hsa051600.44058840
127African trypanosomiasis_Homo sapiens_hsa051430.40207717

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