ST6GALNAC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a Golgi type II transmembrane glycosyltransferase. The encoded protein catalyzes the transfer of sialic acid to cell surface proteins to modulate cell-cell interactions. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ionotropic glutamate receptor signaling pathway (GO:0035235)5.83851257
2pyrimidine nucleobase catabolic process (GO:0006208)5.68601442
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39166148
4glutamate receptor signaling pathway (GO:0007215)5.33036076
5vocalization behavior (GO:0071625)5.31174828
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.17366422
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.17315568
8locomotory exploration behavior (GO:0035641)5.01476518
9protein localization to synapse (GO:0035418)4.96440169
10regulation of glutamate receptor signaling pathway (GO:1900449)4.85207669
11neuron cell-cell adhesion (GO:0007158)4.84720276
12synaptic transmission, glutamatergic (GO:0035249)4.73336235
13synaptic vesicle exocytosis (GO:0016079)4.68913846
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.67875676
15exploration behavior (GO:0035640)4.63765557
16nucleobase catabolic process (GO:0046113)4.56220705
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.46117774
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.41322514
19neuron-neuron synaptic transmission (GO:0007270)4.41292707
20neuron recognition (GO:0008038)4.35759931
21regulation of neuronal synaptic plasticity (GO:0048168)4.25892694
22glutamate secretion (GO:0014047)4.25367130
23regulation of synaptic vesicle exocytosis (GO:2000300)4.15879524
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.09294761
25regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08657439
26neuronal action potential propagation (GO:0019227)4.07564561
27behavioral fear response (GO:0001662)4.06124070
28behavioral defense response (GO:0002209)4.06124070
29long-term memory (GO:0007616)4.00231910
30synaptic vesicle maturation (GO:0016188)3.98849438
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.94080743
32regulation of synaptic vesicle transport (GO:1902803)3.94004157
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.93504799
34nonmotile primary cilium assembly (GO:0035058)3.92351207
35axonal fasciculation (GO:0007413)3.91989495
36regulation of postsynaptic membrane potential (GO:0060078)3.91420163
37fear response (GO:0042596)3.90843995
38calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.87125903
39innervation (GO:0060384)3.81268063
40synaptic vesicle endocytosis (GO:0048488)3.78991165
41positive regulation of synapse maturation (GO:0090129)3.78409957
42dendritic spine morphogenesis (GO:0060997)3.77995014
43long-term synaptic potentiation (GO:0060291)3.76763332
44regulation of synaptic plasticity (GO:0048167)3.76219653
45regulation of dendritic spine morphogenesis (GO:0061001)3.73371505
46negative regulation of synaptic transmission, GABAergic (GO:0032229)3.68926482
47neurotransmitter-gated ion channel clustering (GO:0072578)3.67709408
48retinal ganglion cell axon guidance (GO:0031290)3.67168309
49positive regulation of mitochondrial fission (GO:0090141)3.65899617
50response to histamine (GO:0034776)3.63649569
51presynaptic membrane assembly (GO:0097105)3.62436173
52regulation of vesicle fusion (GO:0031338)3.60160363
53proline transport (GO:0015824)3.59700313
54positive regulation of neurotransmitter secretion (GO:0001956)3.57917508
55dendritic spine organization (GO:0097061)3.57725312
56G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.56842270
57olfactory bulb development (GO:0021772)3.53784647
58transmission of nerve impulse (GO:0019226)3.52825068
59regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.51924159
60neurotransmitter secretion (GO:0007269)3.51042540
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.50347779
62sequestering of actin monomers (GO:0042989)3.50236333
63intraciliary transport (GO:0042073)3.47055516
64positive regulation of membrane potential (GO:0045838)3.46676949
65cellular potassium ion homeostasis (GO:0030007)3.46305124
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.46198349
67postsynaptic membrane organization (GO:0001941)3.45778861
68response to nitrosative stress (GO:0051409)3.43259835
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.38057570
70chemosensory behavior (GO:0007635)3.29451751
71startle response (GO:0001964)3.29293779
72presynaptic membrane organization (GO:0097090)3.28442172
73learning (GO:0007612)3.28204171
74positive regulation of dendritic spine development (GO:0060999)3.28144506
75layer formation in cerebral cortex (GO:0021819)3.27555118
76regulation of synapse structural plasticity (GO:0051823)3.27462193
77regulation of glutamate secretion (GO:0014048)3.26546365
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26284108
79cochlea development (GO:0090102)3.25667692
80long term synaptic depression (GO:0060292)3.24258581
81regulation of female receptivity (GO:0045924)3.24205885
82regulation of dendritic spine development (GO:0060998)3.20873158
83membrane depolarization (GO:0051899)3.19435430
84positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15706179
85positive regulation of neurotransmitter transport (GO:0051590)3.13522442
86detection of calcium ion (GO:0005513)3.11961293
87female mating behavior (GO:0060180)3.10103812
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09146912
89neurotransmitter transport (GO:0006836)3.08810644
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08644616
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07906886
92auditory behavior (GO:0031223)3.07818932
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05323039
94microtubule depolymerization (GO:0007019)3.05229712
95inner ear receptor cell development (GO:0060119)3.02786846
96cell communication by electrical coupling (GO:0010644)3.02461482
97regulation of neurotransmitter secretion (GO:0046928)3.01659552
98regulation of synapse maturation (GO:0090128)3.01655143
99central nervous system projection neuron axonogenesis (GO:0021952)3.01010460
100vesicle transport along microtubule (GO:0047496)3.00441454
101regulation of synaptic transmission (GO:0050804)2.99652090
102gamma-aminobutyric acid transport (GO:0015812)2.99639417
103positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98023484
104neuron projection extension involved in neuron projection guidance (GO:1902284)2.97820102
105axon extension involved in axon guidance (GO:0048846)2.97820102
106epithelial cilium movement (GO:0003351)2.96480151
107cerebral cortex radially oriented cell migration (GO:0021799)2.95475141
108mechanosensory behavior (GO:0007638)2.94707198
109synaptic transmission (GO:0007268)2.93715608
110positive regulation of vesicle fusion (GO:0031340)2.91747422
111membrane depolarization during action potential (GO:0086010)2.91442642
112behavioral response to cocaine (GO:0048148)2.90517856
113positive regulation of synaptic transmission (GO:0050806)2.88515693
114positive regulation of synapse assembly (GO:0051965)2.88484946
115establishment of nucleus localization (GO:0040023)2.88125417
116limb bud formation (GO:0060174)2.86797811
117synapse assembly (GO:0007416)2.85286359
118regulation of neuron projection regeneration (GO:0070570)2.84487838
119regulation of axon regeneration (GO:0048679)2.84487838
120neuromuscular synaptic transmission (GO:0007274)2.84090664
121central nervous system neuron axonogenesis (GO:0021955)2.83246890
122ephrin receptor signaling pathway (GO:0048013)2.81881693
123regulation of neurotransmitter levels (GO:0001505)2.81476300
124limb development (GO:0060173)2.80037807
125appendage development (GO:0048736)2.80037807
126behavioral response to nicotine (GO:0035095)2.75324803
127negative regulation of microtubule polymerization (GO:0031115)2.72761590
128short-term memory (GO:0007614)2.71256106
129establishment of mitochondrion localization (GO:0051654)2.70092348
130cilium morphogenesis (GO:0060271)2.68816703
131somite development (GO:0061053)2.67342523
132protein localization to cilium (GO:0061512)2.66456894
133regulation of respiratory system process (GO:0044065)2.65345763
134neural tube formation (GO:0001841)2.62688143
135cilium assembly (GO:0042384)2.61852976
136epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61658587
137regulation of development, heterochronic (GO:0040034)2.61569461
138cilium organization (GO:0044782)2.60552842
139neuron fate determination (GO:0048664)2.60293247
140ganglion development (GO:0061548)2.60230400
141cell migration in hindbrain (GO:0021535)2.58240688
142neuronal stem cell maintenance (GO:0097150)2.57472833
143negative chemotaxis (GO:0050919)2.55212358
144protein polyglutamylation (GO:0018095)2.55003949
145dorsal/ventral pattern formation (GO:0009953)2.51839600
146regulation of cilium movement (GO:0003352)2.50570149
147C4-dicarboxylate transport (GO:0015740)2.50197775
148homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.49879513
149hindbrain development (GO:0030902)2.48581233
150dendrite morphogenesis (GO:0048813)2.46430737
151regulation of cell fate specification (GO:0042659)2.44336033
152axon extension (GO:0048675)2.43654491
153mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.43501688
154positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.43501688
155synapse organization (GO:0050808)2.43078043
156cullin deneddylation (GO:0010388)2.42508912
157cilium movement (GO:0003341)2.42263803
158smoothened signaling pathway (GO:0007224)2.40641521
159regulation of mitochondrial fission (GO:0090140)2.38662853
160behavioral response to ethanol (GO:0048149)2.38662360
161substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.37252363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45073052
2GBX2_23144817_ChIP-Seq_PC3_Human4.20949898
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.18098223
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12601463
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06412827
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.75002842
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64143566
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64143566
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62174094
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62021774
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.56421853
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.55807325
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47124158
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46115454
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44313683
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.40831929
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37198048
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.18532604
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17476518
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.16626684
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.09971243
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.08914136
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07969501
24DROSHA_22980978_ChIP-Seq_HELA_Human2.04549971
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96077030
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94749990
27* REST_18959480_ChIP-ChIP_MESCs_Mouse1.91987096
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86256546
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.82426838
30TAF15_26573619_Chip-Seq_HEK293_Human1.81736237
31IRF1_19129219_ChIP-ChIP_H3396_Human1.80595502
32AR_21572438_ChIP-Seq_LNCaP_Human1.79162173
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76155250
34* P300_19829295_ChIP-Seq_ESCs_Human1.74010910
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72905546
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71072754
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.69737836
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69071684
39EWS_26573619_Chip-Seq_HEK293_Human1.68748700
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65265160
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64470908
42VDR_22108803_ChIP-Seq_LS180_Human1.60448264
43ZNF274_21170338_ChIP-Seq_K562_Hela1.60153962
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59409072
45IGF1R_20145208_ChIP-Seq_DFB_Human1.55296812
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55246978
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54284920
48FUS_26573619_Chip-Seq_HEK293_Human1.54156479
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53552497
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.53412039
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51790002
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50447801
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.46468926
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46246313
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45154736
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43847525
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43742042
58* AR_25329375_ChIP-Seq_VCAP_Human1.41282678
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.40362910
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38992872
61FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38786420
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.34255306
63* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33084988
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32223470
65TP53_16413492_ChIP-PET_HCT116_Human1.31331945
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30802303
67* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.27693175
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.27537117
69* STAT3_23295773_ChIP-Seq_U87_Human1.26974097
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26584715
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25975888
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.25943291
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20697476
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.20039041
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20014622
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18633332
77CBP_20019798_ChIP-Seq_JUKART_Human1.16594337
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16594337
79KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16483193
80SOX9_26525672_Chip-Seq_HEART_Mouse1.15003747
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.14391884
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13908037
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.13896855
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.13608017
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13278966
86* TCF4_23295773_ChIP-Seq_U87_Human1.12911886
87RNF2_27304074_Chip-Seq_NSC_Mouse1.12706882
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.12654919
89* AR_19668381_ChIP-Seq_PC3_Human1.12395640
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12330482
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12270153
92* ERG_21242973_ChIP-ChIP_JURKAT_Human1.12200561
93RUNX2_22187159_ChIP-Seq_PCA_Human1.12187271
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.11664472
95* TP53_18474530_ChIP-ChIP_U2OS_Human1.10733098
96JUN_21703547_ChIP-Seq_K562_Human1.10709148
97HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10494047
98* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09865604
99BCAT_22108803_ChIP-Seq_LS180_Human1.09576975
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09205017
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08996276
102TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08996276
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08930147
104STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07867568
105* NANOG_18555785_Chip-Seq_ESCs_Mouse1.07670253
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.07389739
107RING1B_27294783_Chip-Seq_NPCs_Mouse1.06561274
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05756637
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04452783
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.02873729
111MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02233445
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01526246
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01416663
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01215315
115AHR_22903824_ChIP-Seq_MCF-7_Human1.00765666
116* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00271213
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99032542
118FLI1_21867929_ChIP-Seq_TH2_Mouse0.98518068
119* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97829542
120ER_23166858_ChIP-Seq_MCF-7_Human0.97073039
121MYC_18940864_ChIP-ChIP_HL60_Human0.96052136
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95355840
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.94991100
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94663465
125* E2F1_18555785_Chip-Seq_ESCs_Mouse0.94331007
126* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93620787
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.92392617
128* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92100424
129* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91560573
130VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90365913

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.68442190
2MP0003880_abnormal_central_pattern5.60728821
3MP0003635_abnormal_synaptic_transmissio4.11616372
4MP0004270_analgesia3.65634378
5MP0009745_abnormal_behavioral_response3.51469665
6MP0002063_abnormal_learning/memory/cond3.47921410
7MP0002064_seizures3.01502728
8MP0001968_abnormal_touch/_nociception2.99470614
9MP0002572_abnormal_emotion/affect_behav2.95566738
10MP0002653_abnormal_ependyma_morphology2.78546838
11MP0001501_abnormal_sleep_pattern2.70150882
12MP0002736_abnormal_nociception_after2.69134547
13MP0002735_abnormal_chemical_nociception2.63311693
14MP0002822_catalepsy2.55501952
15MP0002272_abnormal_nervous_system2.52736394
16MP0001440_abnormal_grooming_behavior2.52493396
17MP0001486_abnormal_startle_reflex2.40833569
18MP0009046_muscle_twitch2.36230827
19MP0002734_abnormal_mechanical_nocicepti2.31919677
20MP0005423_abnormal_somatic_nervous2.23094084
21MP0003121_genomic_imprinting2.08171339
22MP0008789_abnormal_olfactory_epithelium2.04047153
23MP0009780_abnormal_chondrocyte_physiolo2.02632250
24MP0000778_abnormal_nervous_system1.99719496
25MP0006276_abnormal_autonomic_nervous1.99563819
26MP0002067_abnormal_sensory_capabilities1.89986930
27MP0002733_abnormal_thermal_nociception1.89595150
28MP0003329_amyloid_beta_deposits1.88691509
29MP0000566_synostosis1.86794177
30MP0002184_abnormal_innervation1.84500640
31MP0001970_abnormal_pain_threshold1.83047423
32MP0004133_heterotaxia1.81524796
33MP0001188_hyperpigmentation1.75185314
34MP0000569_abnormal_digit_pigmentation1.73489945
35MP0000049_abnormal_middle_ear1.71914576
36MP0002557_abnormal_social/conspecific_i1.68544390
37MP0004858_abnormal_nervous_system1.66674324
38MP0002837_dystrophic_cardiac_calcinosis1.62388590
39MP0001529_abnormal_vocalization1.61930402
40MP0003787_abnormal_imprinting1.60627318
41MP0004924_abnormal_behavior1.59157526
42MP0005386_behavior/neurological_phenoty1.59157526
43MP0005646_abnormal_pituitary_gland1.58841570
44MP0002233_abnormal_nose_morphology1.58836635
45MP0001299_abnormal_eye_distance/1.55335766
46MP0004811_abnormal_neuron_physiology1.49395280
47MP0005253_abnormal_eye_physiology1.49100928
48MP0001293_anophthalmia1.47775359
49MP0002909_abnormal_adrenal_gland1.47176397
50MP0001905_abnormal_dopamine_level1.44164966
51MP0005645_abnormal_hypothalamus_physiol1.43938807
52MP0003937_abnormal_limbs/digits/tail_de1.43643915
53MP0000955_abnormal_spinal_cord1.43492852
54MP0006292_abnormal_olfactory_placode1.42077908
55MP0002751_abnormal_autonomic_nervous1.37685364
56MP0001502_abnormal_circadian_rhythm1.36566063
57MP0008569_lethality_at_weaning1.35371486
58MP0002882_abnormal_neuron_morphology1.34746229
59MP0003879_abnormal_hair_cell1.34427783
60MP0003567_abnormal_fetal_cardiomyocyte1.34069998
61MP0002066_abnormal_motor_capabilities/c1.30987888
62MP0001984_abnormal_olfaction1.30510252
63MP0010386_abnormal_urinary_bladder1.29573891
64MP0004885_abnormal_endolymph1.27026659
65MP0010030_abnormal_orbit_morphology1.22954668
66MP0003890_abnormal_embryonic-extraembry1.20339621
67MP0003633_abnormal_nervous_system1.19413842
68MP0002938_white_spotting1.18702631
69MP0005248_abnormal_Harderian_gland1.18285908
70MP0000383_abnormal_hair_follicle1.16406463
71MP0008877_abnormal_DNA_methylation1.12041439
72MP0000647_abnormal_sebaceous_gland1.07144093
73MP0002152_abnormal_brain_morphology1.05987728
74MP0005409_darkened_coat_color1.05875897
75MP0002009_preneoplasia1.03096956
76MP0003631_nervous_system_phenotype1.02444396
77MP0004142_abnormal_muscle_tone1.02002077
78MP0000427_abnormal_hair_cycle1.01093421
79MP0001286_abnormal_eye_development0.98941361
80MP0005391_vision/eye_phenotype0.98371910
81MP0005551_abnormal_eye_electrophysiolog0.98121343
82MP0003755_abnormal_palate_morphology0.97471544
83MP0002876_abnormal_thyroid_physiology0.97214211
84MP0002069_abnormal_eating/drinking_beha0.96622654
85MP0003122_maternal_imprinting0.95775685
86MP0001963_abnormal_hearing_physiology0.93182991
87MP0002163_abnormal_gland_morphology0.92524061
88MP0003119_abnormal_digestive_system0.90745691
89MP0005535_abnormal_body_temperature0.89937475
90MP0004484_altered_response_of0.89406700
91MP0004145_abnormal_muscle_electrophysio0.88697448
92MP0003136_yellow_coat_color0.88656380
93MP0004742_abnormal_vestibular_system0.87878718
94MP0004085_abnormal_heartbeat0.87649014
95MP0003011_delayed_dark_adaptation0.87036875
96MP0002229_neurodegeneration0.84977911
97MP0002638_abnormal_pupillary_reflex0.84026364
98MP0000534_abnormal_ureter_morphology0.83840563
99MP0003942_abnormal_urinary_system0.83760816
100MP0005195_abnormal_posterior_eye0.83165646
101MP0000579_abnormal_nail_morphology0.81637692
102MP0002697_abnormal_eye_size0.81265817
103MP0000604_amyloidosis0.81132039
104MP0000751_myopathy0.80297224
105MP0000631_abnormal_neuroendocrine_gland0.80214433
106MP0008872_abnormal_physiological_respon0.79647783
107MP0008874_decreased_physiological_sensi0.79163672
108MP0004215_abnormal_myocardial_fiber0.78261507
109MP0001664_abnormal_digestion0.78059402
110MP0004510_myositis0.76816294
111MP0005499_abnormal_olfactory_system0.76725116
112MP0005394_taste/olfaction_phenotype0.76725116
113MP0010678_abnormal_skin_adnexa0.76396029
114MP0002752_abnormal_somatic_nervous0.75485207
115MP0001485_abnormal_pinna_reflex0.73238019
116MP0000026_abnormal_inner_ear0.69599371
117MP0003075_altered_response_to0.67219131
118MP0003632_abnormal_nervous_system0.66630156
119MP0001177_atelectasis0.66566030
120MP0003634_abnormal_glial_cell0.66358545
121MP0000678_abnormal_parathyroid_gland0.64357828
122MP0002234_abnormal_pharynx_morphology0.63652238
123MP0005379_endocrine/exocrine_gland_phen0.63571107
124MP0002102_abnormal_ear_morphology0.61143374
125MP0001765_abnormal_ion_homeostasis0.59847980
126MP0003938_abnormal_ear_development0.58679808
127MP0005187_abnormal_penis_morphology0.58659555
128MP0000013_abnormal_adipose_tissue0.57544053
129MP0005595_abnormal_vascular_smooth0.57437823
130MP0003861_abnormal_nervous_system0.56046792
131MP0006072_abnormal_retinal_apoptosis0.55950372
132MP0003137_abnormal_impulse_conducting0.52355163
133MP0005171_absent_coat_pigmentation0.50206176
134MP0003283_abnormal_digestive_organ0.49920804
135MP0002090_abnormal_vision0.47710421
136MP0004043_abnormal_pH_regulation0.46252315

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.45128915
2Myokymia (HP:0002411)6.11733761
3Focal seizures (HP:0007359)5.73264599
4Visual hallucinations (HP:0002367)5.23997384
5Epileptic encephalopathy (HP:0200134)5.18042728
6Atonic seizures (HP:0010819)4.68435363
7Hyperventilation (HP:0002883)4.66794590
8Febrile seizures (HP:0002373)4.63455111
9Absence seizures (HP:0002121)4.44911489
10Dialeptic seizures (HP:0011146)4.16490219
11Progressive cerebellar ataxia (HP:0002073)4.13155427
12Cerebral inclusion bodies (HP:0100314)3.96898517
13Generalized tonic-clonic seizures (HP:0002069)3.95087584
14Amblyopia (HP:0000646)3.68971044
15Medial flaring of the eyebrow (HP:0010747)3.60068898
16Broad-based gait (HP:0002136)3.51778232
17Congenital primary aphakia (HP:0007707)3.49341019
18Supranuclear gaze palsy (HP:0000605)3.48440014
19Excessive salivation (HP:0003781)3.40676259
20Drooling (HP:0002307)3.40676259
21Neurofibrillary tangles (HP:0002185)3.39784059
22Nephrogenic diabetes insipidus (HP:0009806)3.24844526
23True hermaphroditism (HP:0010459)3.21334673
24Action tremor (HP:0002345)3.14404213
25Colon cancer (HP:0003003)3.12770937
26Diplopia (HP:0000651)3.05931430
27Abnormality of binocular vision (HP:0011514)3.05931430
28Dysmetria (HP:0001310)3.03632637
29Epileptiform EEG discharges (HP:0011182)3.01970298
30Truncal ataxia (HP:0002078)3.01332081
31Limb dystonia (HP:0002451)2.99936032
32Hemiparesis (HP:0001269)2.99606050
33Impaired vibration sensation in the lower limbs (HP:0002166)2.99251959
34Anxiety (HP:0000739)2.98247861
35Intestinal atresia (HP:0011100)2.90037720
36Poor eye contact (HP:0000817)2.81275387
37Dysdiadochokinesis (HP:0002075)2.80133676
38Depression (HP:0000716)2.75253365
39Gaze-evoked nystagmus (HP:0000640)2.73938559
40Vaginal atresia (HP:0000148)2.72569395
41Absent speech (HP:0001344)2.72550035
42Genital tract atresia (HP:0001827)2.70632048
43Nephronophthisis (HP:0000090)2.67902978
44EEG with generalized epileptiform discharges (HP:0011198)2.67241843
45Specific learning disability (HP:0001328)2.60542967
46Pancreatic fibrosis (HP:0100732)2.58901812
47Cortical dysplasia (HP:0002539)2.58377919
48Pancreatic cysts (HP:0001737)2.54427374
49Hyperglycinemia (HP:0002154)2.51533104
50Thickened helices (HP:0000391)2.50413905
51Abnormality of midbrain morphology (HP:0002418)2.50410481
52Molar tooth sign on MRI (HP:0002419)2.50410481
53Progressive inability to walk (HP:0002505)2.50273042
54Impaired social interactions (HP:0000735)2.48899466
55Abnormal social behavior (HP:0012433)2.48899466
56Poor coordination (HP:0002370)2.48489521
57Broad foot (HP:0001769)2.48035145
58Lissencephaly (HP:0001339)2.46191611
59Delusions (HP:0000746)2.45037971
60Postaxial hand polydactyly (HP:0001162)2.43329940
61Urinary bladder sphincter dysfunction (HP:0002839)2.42449667
62Abnormality of salivation (HP:0100755)2.41840280
63Hypsarrhythmia (HP:0002521)2.41340596
64Exercise-induced muscle cramps (HP:0003710)2.38943565
65Inability to walk (HP:0002540)2.36865305
66Abnormal eating behavior (HP:0100738)2.35576783
67Impaired smooth pursuit (HP:0007772)2.30036923
68Hepatoblastoma (HP:0002884)2.29112848
69Megalencephaly (HP:0001355)2.28526515
70Postural instability (HP:0002172)2.27908364
71Aplasia/Hypoplasia of the tongue (HP:0010295)2.26785164
72Genetic anticipation (HP:0003743)2.26350515
73Optic nerve hypoplasia (HP:0000609)2.25797777
74Retinal dysplasia (HP:0007973)2.25548264
75Termporal pattern (HP:0011008)2.24477312
76Insidious onset (HP:0003587)2.24477312
77Hydroureter (HP:0000072)2.22205894
78Stereotypic behavior (HP:0000733)2.21219133
79Abnormality of the labia minora (HP:0012880)2.19141290
80Bradykinesia (HP:0002067)2.18942123
81Mutism (HP:0002300)2.18541014
82Protruding tongue (HP:0010808)2.16868907
83Decreased circulating renin level (HP:0003351)2.14827341
84Postaxial foot polydactyly (HP:0001830)2.14383185
85Hypothermia (HP:0002045)2.13662386
86Breast aplasia (HP:0100783)2.13491322
87Aplasia/Hypoplasia of the breasts (HP:0010311)2.13381683
88Type II lissencephaly (HP:0007260)2.13004376
89Scanning speech (HP:0002168)2.11752541
90Vitreoretinal degeneration (HP:0000655)2.11007640
91Abnormality of the renal medulla (HP:0100957)2.10747457
92Hypoplastic pelvis (HP:0008839)2.09921997
93Urinary urgency (HP:0000012)2.06668410
94Psychosis (HP:0000709)2.06010710
95Status epilepticus (HP:0002133)2.05642924
96Poor suck (HP:0002033)2.05555529
97Tented upper lip vermilion (HP:0010804)2.05202313
98Narrow forehead (HP:0000341)2.04991710
99Fetal akinesia sequence (HP:0001989)2.03131928
100Abnormality of the lower motor neuron (HP:0002366)2.03057228
101Tubulointerstitial nephritis (HP:0001970)2.02842050
102Sclerocornea (HP:0000647)2.01926519
103Widely spaced teeth (HP:0000687)2.00157610
104Ankle clonus (HP:0011448)1.99494309
105Decreased testicular size (HP:0008734)1.99023206
106Dyskinesia (HP:0100660)1.97606374
107Generalized myoclonic seizures (HP:0002123)1.97439324
108Increased circulating renin level (HP:0000848)1.96001046
109Erectile abnormalities (HP:0100639)1.95072038
110Dynein arm defect of respiratory motile cilia (HP:0012255)1.94943934
111Absent/shortened dynein arms (HP:0200106)1.94943934
112Fair hair (HP:0002286)1.93262119
113Septo-optic dysplasia (HP:0100842)1.92808757
114Spastic gait (HP:0002064)1.92494926
115Oligodactyly (HP:0012165)1.92207171
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.92089508
117Aplasia involving bones of the upper limbs (HP:0009823)1.91588358
118Aplasia of the phalanges of the hand (HP:0009802)1.91588358
119Aplasia involving bones of the extremities (HP:0009825)1.91588358
120Abnormality of the corticospinal tract (HP:0002492)1.90655326
121Bifid tongue (HP:0010297)1.89608797
122Impaired vibratory sensation (HP:0002495)1.87859697
123Lower limb muscle weakness (HP:0007340)1.87536738
124Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.86577264
125Blue irides (HP:0000635)1.86509441
126Micropenis (HP:0000054)1.86264177
127Abnormality of ocular smooth pursuit (HP:0000617)1.86169059
128Dysautonomia (HP:0002459)1.85800783
129Gait imbalance (HP:0002141)1.85353534
130Pachygyria (HP:0001302)1.84735796
131Chronic hepatic failure (HP:0100626)1.84422555
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.83980359
133Incomplete penetrance (HP:0003829)1.83244379
134Supernumerary spleens (HP:0009799)1.83237152
135Anophthalmia (HP:0000528)1.82519451
136Gait ataxia (HP:0002066)1.81993124
137Broad alveolar ridges (HP:0000187)1.81727276
138Aplasia/Hypoplasia of the lens (HP:0008063)1.81223103
139Amyotrophic lateral sclerosis (HP:0007354)1.81181750
140Rapidly progressive (HP:0003678)1.80418910
141Polyphagia (HP:0002591)1.79712783
142Generalized hypopigmentation of hair (HP:0011358)1.79245395
143Gastroesophageal reflux (HP:0002020)1.78643787
144Failure to thrive in infancy (HP:0001531)1.77394935
145Global brain atrophy (HP:0002283)1.77377885
146Morphological abnormality of the pyramidal tract (HP:0002062)1.76937021
147Focal dystonia (HP:0004373)1.76903459
148Oligodactyly (hands) (HP:0001180)1.76527715
149Short foot (HP:0001773)1.76495659
150Exotropia (HP:0000577)1.76489144
151Abnormality of the intervertebral disk (HP:0005108)1.73743273
152Aganglionic megacolon (HP:0002251)1.73260324
153Autism (HP:0000717)1.71960325
154Cerebellar dysplasia (HP:0007033)1.71886472
155Abnormal ciliary motility (HP:0012262)1.71613432
156Thyroid-stimulating hormone excess (HP:0002925)1.71541721
157Agitation (HP:0000713)1.71457401
158Postnatal microcephaly (HP:0005484)1.70706437
159Split foot (HP:0001839)1.70449663
160Intention tremor (HP:0002080)1.68962165
161Renal hypoplasia (HP:0000089)1.68575926
162Torticollis (HP:0000473)1.68489761
163Papilledema (HP:0001085)1.68109649
164Abnormality of the metopic suture (HP:0005556)1.67981924
165Anencephaly (HP:0002323)1.66537763
166Preaxial hand polydactyly (HP:0001177)1.66005565
167Cystic liver disease (HP:0006706)1.65758981
168Aplasia/Hypoplasia of the tibia (HP:0005772)1.65158846
169Abnormality of the ileum (HP:0001549)1.64969599
170Spastic tetraplegia (HP:0002510)1.63178445
171Short tibia (HP:0005736)1.63171073
172Labial hypoplasia (HP:0000066)1.62906132
173Hypoplasia of the brainstem (HP:0002365)1.62741963
174Aplasia/Hypoplasia of the brainstem (HP:0007362)1.62741963
175Abnormality of the phalanges of the 2nd finger (HP:0009541)1.61643768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.65319308
2NTRK35.21609376
3RIPK43.32785102
4MAP3K92.91488976
5MAP3K42.82655489
6MAP2K72.51123918
7MINK12.50587237
8CASK2.36985664
9PNCK2.31674581
10MARK12.22356322
11TRIM282.16000196
12MAP3K122.14580912
13SRPK12.08148521
14PLK22.06583749
15TNIK1.94446334
16SIK21.91495781
17DYRK21.89142324
18KSR21.87817387
19KSR11.83275152
20GRK51.72782953
21MAP2K41.70659989
22DAPK11.69993879
23PTK2B1.66718991
24MAP4K21.66368735
25MAP3K131.64584894
26DAPK21.63008812
27CSNK1G31.62608671
28NME11.56917090
29BMPR21.56838813
30NTRK21.56386260
31NTRK11.55175459
32MKNK11.53840186
33CSNK1A1L1.52820113
34PRPF4B1.51841893
35ERBB31.50050856
36EPHB21.49833455
37DYRK31.49740692
38PRKD31.44180993
39PAK61.42955672
40CDK51.41886701
41CSNK1G11.40283017
42FES1.39455097
43ARAF1.39106651
44FGR1.36358064
45WEE11.33366274
46CAMK2A1.33312375
47PRKCG1.32547642
48MAPK131.27626482
49CAMK2B1.25476662
50DYRK1B1.21726107
51LIMK11.12731754
52MKNK21.11601158
53ZAK1.11562913
54BMPR1B1.09629831
55STK38L1.09466731
56EPHA31.08965575
57ADRBK21.08610044
58BRD41.07403906
59RAF11.04492107
60STK381.02325744
61MAPK150.98134021
62DYRK1A0.96982804
63CAMKK10.95393938
64MAP3K20.93858323
65SIK30.90857120
66CDC70.90815631
67RPS6KA40.85468387
68PLK30.85066791
69MAP3K60.81321988
70CAMK10.80106218
71PKN10.78952851
72BCKDK0.77601436
73FER0.77540211
74GRK60.77357589
75MAP3K70.77199204
76SGK10.77008829
77PAK30.74868274
78GRK70.74711917
79LATS20.74174951
80CAMK40.72748127
81PRKCE0.71791873
82NEK10.71546645
83SGK2230.70717290
84SGK4940.70717290
85PHKG20.68832904
86PHKG10.68832904
87BRSK10.68752877
88SGK20.67486236
89CDK140.66856110
90FRK0.66564483
91CDK180.66432483
92CAMK2D0.66160243
93AKT30.65539011
94UHMK10.64891270
95INSRR0.62906636
96CDK190.62732602
97CDK150.62636006
98PLK40.60823311
99DMPK0.60588445
100STK110.58638146
101TIE10.58403594
102MARK20.55922598
103PLK10.55259648
104CDK11A0.54005342
105RET0.52294839
106ERBB20.52132570
107PRKCZ0.50430139
108VRK10.50341338
109TYRO30.48394408
110CAMK1G0.48125464
111MAP2K10.48041870
112MAP3K10.47766618
113MUSK0.47448293
114CCNB10.47268268
115BCR0.45811547
116BRAF0.45810822
117CSNK1G20.45770307
118TESK10.44644556
119WNK30.44243003
120CAMK2G0.42615590
121ATR0.42538179
122MAPK100.41942144
123TNK20.41824498
124PDK10.41016792
125OXSR10.40061161
126PDPK10.39293430
127MET0.38761227
128CSNK1A10.38084062
129FYN0.37967687
130PRKCQ0.37663564
131BRSK20.37600261
132RPS6KA30.37348427
133SGK30.37273328
134ROCK20.37006811
135CAMKK20.36935087
136PINK10.35910548
137PRKACB0.35684069
138PRKD20.35431868
139PRKACA0.35016404
140PRKCH0.33612864
141CSNK1D0.33510863
142PIK3CA0.32770699
143RPS6KA50.32691700
144CDK80.32644086
145YES10.32285651
146PRKCA0.32165828
147PRKCB0.31083814
148ADRBK10.29988265

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.52176259
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.36653414
3Long-term potentiation_Homo sapiens_hsa047203.23235903
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.99322570
5Circadian entrainment_Homo sapiens_hsa047132.90615289
6Amphetamine addiction_Homo sapiens_hsa050312.84963850
7Glutamatergic synapse_Homo sapiens_hsa047242.84401926
8Protein export_Homo sapiens_hsa030602.73430925
9Synaptic vesicle cycle_Homo sapiens_hsa047212.61804221
10GABAergic synapse_Homo sapiens_hsa047272.57979812
11Morphine addiction_Homo sapiens_hsa050322.52608798
12Salivary secretion_Homo sapiens_hsa049702.39858762
13Olfactory transduction_Homo sapiens_hsa047402.36106290
14Butanoate metabolism_Homo sapiens_hsa006502.31379897
15Dopaminergic synapse_Homo sapiens_hsa047282.27122021
16Taste transduction_Homo sapiens_hsa047422.07326312
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02674425
18Steroid biosynthesis_Homo sapiens_hsa001002.01682333
19Renin secretion_Homo sapiens_hsa049241.97204151
20Insulin secretion_Homo sapiens_hsa049111.95555253
21Serotonergic synapse_Homo sapiens_hsa047261.93886514
22Calcium signaling pathway_Homo sapiens_hsa040201.93335832
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.92272368
24Long-term depression_Homo sapiens_hsa047301.87234288
25Gastric acid secretion_Homo sapiens_hsa049711.82065505
26Cholinergic synapse_Homo sapiens_hsa047251.81859601
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81050655
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70709716
29Collecting duct acid secretion_Homo sapiens_hsa049661.68747234
30Oxytocin signaling pathway_Homo sapiens_hsa049211.67648900
31Cocaine addiction_Homo sapiens_hsa050301.67418015
32Propanoate metabolism_Homo sapiens_hsa006401.59162392
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49355465
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47283298
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43112007
36GnRH signaling pathway_Homo sapiens_hsa049121.42406006
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41362900
38Fatty acid elongation_Homo sapiens_hsa000621.40225390
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38907001
40cAMP signaling pathway_Homo sapiens_hsa040241.38030326
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31477601
42Gap junction_Homo sapiens_hsa045401.29747578
43Axon guidance_Homo sapiens_hsa043601.23354276
44Hippo signaling pathway_Homo sapiens_hsa043901.19956791
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18369691
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18096480
47Hedgehog signaling pathway_Homo sapiens_hsa043401.15322891
48Fanconi anemia pathway_Homo sapiens_hsa034601.14681886
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14090129
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12736753
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11288499
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10765776
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09587438
54Phototransduction_Homo sapiens_hsa047441.09119258
55Glioma_Homo sapiens_hsa052141.08904208
56Vitamin B6 metabolism_Homo sapiens_hsa007501.08718182
57Estrogen signaling pathway_Homo sapiens_hsa049151.08297578
58Melanogenesis_Homo sapiens_hsa049161.07609798
59Cardiac muscle contraction_Homo sapiens_hsa042601.05734461
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03827370
61Basal cell carcinoma_Homo sapiens_hsa052171.03114258
62Basal transcription factors_Homo sapiens_hsa030221.01352831
63Alzheimers disease_Homo sapiens_hsa050101.00426599
64Type II diabetes mellitus_Homo sapiens_hsa049301.00394630
65Vibrio cholerae infection_Homo sapiens_hsa051100.99917924
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.99380027
67Pancreatic secretion_Homo sapiens_hsa049720.97447764
68Regulation of autophagy_Homo sapiens_hsa041400.97035636
69Folate biosynthesis_Homo sapiens_hsa007900.94868500
70ErbB signaling pathway_Homo sapiens_hsa040120.92469382
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90434067
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88062648
73Choline metabolism in cancer_Homo sapiens_hsa052310.87614243
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84044153
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82626723
76beta-Alanine metabolism_Homo sapiens_hsa004100.81767725
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.81189064
78African trypanosomiasis_Homo sapiens_hsa051430.78822694
79Oxidative phosphorylation_Homo sapiens_hsa001900.78029950
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.77437391
81Dorso-ventral axis formation_Homo sapiens_hsa043200.77295309
82Oocyte meiosis_Homo sapiens_hsa041140.76511342
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.74515701
84Glucagon signaling pathway_Homo sapiens_hsa049220.72010331
85Thyroid hormone synthesis_Homo sapiens_hsa049180.71602606
86Biosynthesis of amino acids_Homo sapiens_hsa012300.69819949
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69633161
88VEGF signaling pathway_Homo sapiens_hsa043700.68149573
89Homologous recombination_Homo sapiens_hsa034400.65971357
90Peroxisome_Homo sapiens_hsa041460.63252532
91Tight junction_Homo sapiens_hsa045300.62104563
92Ras signaling pathway_Homo sapiens_hsa040140.61066887
93MAPK signaling pathway_Homo sapiens_hsa040100.60563589
94Dilated cardiomyopathy_Homo sapiens_hsa054140.59779388
95Fatty acid metabolism_Homo sapiens_hsa012120.58944754
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58925286
97TGF-beta signaling pathway_Homo sapiens_hsa043500.57958541
98Rap1 signaling pathway_Homo sapiens_hsa040150.56778446
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56662304
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55932443
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55019043
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.54644063
103mRNA surveillance pathway_Homo sapiens_hsa030150.52645791
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52361894
105Spliceosome_Homo sapiens_hsa030400.51337286
106RNA degradation_Homo sapiens_hsa030180.49904608
107Wnt signaling pathway_Homo sapiens_hsa043100.49241790
108Arginine and proline metabolism_Homo sapiens_hsa003300.47698916
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.47214764
110Selenocompound metabolism_Homo sapiens_hsa004500.46672657
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.46421755
112Circadian rhythm_Homo sapiens_hsa047100.46122120
113* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44833754
114Carbon metabolism_Homo sapiens_hsa012000.44832723
115Base excision repair_Homo sapiens_hsa034100.44282703
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43921288
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43848209
118Alcoholism_Homo sapiens_hsa050340.41665874
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40789818
120Mineral absorption_Homo sapiens_hsa049780.40584950
121Parkinsons disease_Homo sapiens_hsa050120.40023869
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.39864058
123* Metabolic pathways_Homo sapiens_hsa011000.39411633
124Prion diseases_Homo sapiens_hsa050200.38618962
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37996722
126Inositol phosphate metabolism_Homo sapiens_hsa005620.37833916
127Huntingtons disease_Homo sapiens_hsa050160.37796910
128Ether lipid metabolism_Homo sapiens_hsa005650.37267384
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36397196
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36349530
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33669692
132Type I diabetes mellitus_Homo sapiens_hsa049400.33666960
133Cell cycle_Homo sapiens_hsa041100.33458758
134Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31819022
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31665351
136Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31343628
137Non-small cell lung cancer_Homo sapiens_hsa052230.30153019
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29785694
139Rheumatoid arthritis_Homo sapiens_hsa053230.29131741
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29018970
141Bile secretion_Homo sapiens_hsa049760.27083338
142Renal cell carcinoma_Homo sapiens_hsa052110.27027661
143mTOR signaling pathway_Homo sapiens_hsa041500.26701484
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24956185
145Insulin signaling pathway_Homo sapiens_hsa049100.23555231
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20780767
147Ovarian steroidogenesis_Homo sapiens_hsa049130.20401636
148Endocytosis_Homo sapiens_hsa041440.18866349
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16961307

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