ST7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.41619438
2positive regulation of cellular amide metabolic process (GO:0034250)4.33643001
3neuron cell-cell adhesion (GO:0007158)4.31618442
4startle response (GO:0001964)4.24797757
5serotonin receptor signaling pathway (GO:0007210)4.21852656
6vocalization behavior (GO:0071625)4.13330196
7auditory behavior (GO:0031223)4.02735242
8positive regulation of heat generation (GO:0031652)3.97465765
9regulation of fever generation (GO:0031620)3.93572670
10presynaptic membrane assembly (GO:0097105)3.80932360
11nucleobase catabolic process (GO:0046113)3.70131034
12central nervous system projection neuron axonogenesis (GO:0021952)3.69421417
13defense response to protozoan (GO:0042832)3.69254503
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.66473641
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.63826111
16protein neddylation (GO:0045116)3.60251896
17mechanosensory behavior (GO:0007638)3.60006298
18opioid receptor signaling pathway (GO:0038003)3.45788427
19response to auditory stimulus (GO:0010996)3.45263361
20gamma-aminobutyric acid transport (GO:0015812)3.42633118
21negative regulation of mast cell activation (GO:0033004)3.39747874
22positive regulation of mast cell activation involved in immune response (GO:0033008)3.37952291
23positive regulation of mast cell degranulation (GO:0043306)3.37952291
24positive regulation of mitochondrial fission (GO:0090141)3.35780439
25positive regulation of gamma-delta T cell activation (GO:0046645)3.34580858
26presynaptic membrane organization (GO:0097090)3.34447729
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.34410351
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.34410351
29modulation by symbiont of host immune response (GO:0052553)3.34410351
30positive regulation by symbiont of host defense response (GO:0052509)3.34410351
31modulation by symbiont of host defense response (GO:0052031)3.34410351
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.34410351
33regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.29476391
34negative regulation of myeloid cell apoptotic process (GO:0033033)3.26361693
35response to peptidoglycan (GO:0032494)3.23480188
36axonal fasciculation (GO:0007413)3.19931337
37postsynaptic membrane organization (GO:0001941)3.17633994
38neurotransmitter-gated ion channel clustering (GO:0072578)3.15759556
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12124606
40negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09096385
41response to protozoan (GO:0001562)3.07507462
42regulation of glutamate receptor signaling pathway (GO:1900449)3.06585793
43protein localization to synapse (GO:0035418)3.05302613
44neutrophil mediated immunity (GO:0002446)3.03370618
45histamine secretion (GO:0001821)3.03114661
46regulation of action potential (GO:0098900)2.97923213
47behavioral response to nicotine (GO:0035095)2.96735379
48positive regulation of interleukin-1 beta secretion (GO:0050718)2.96734929
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95051350
50mitochondrial respiratory chain complex I assembly (GO:0032981)2.95051350
51NADH dehydrogenase complex assembly (GO:0010257)2.95051350
52glutamate receptor signaling pathway (GO:0007215)2.93694551
53regulation of short-term neuronal synaptic plasticity (GO:0048172)2.91163463
54DNA double-strand break processing (GO:0000729)2.88215752
55cellular response to prostaglandin stimulus (GO:0071379)2.88049043
56protein complex biogenesis (GO:0070271)2.86949082
57positive regulation of action potential (GO:0045760)2.84925806
58establishment of mitochondrion localization (GO:0051654)2.83262345
59detection of molecule of bacterial origin (GO:0032490)2.81756960
60neuron recognition (GO:0008038)2.78529599
61negative chemotaxis (GO:0050919)2.78303114
62positive regulation of mast cell activation (GO:0033005)2.78216329
63regulation of cilium movement (GO:0003352)2.76071496
64immunoglobulin mediated immune response (GO:0016064)2.75212510
65regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.75102846
66negative regulation of viral genome replication (GO:0045071)2.74786005
67synapse assembly (GO:0007416)2.74463895
68superoxide anion generation (GO:0042554)2.74422057
69regulation of heat generation (GO:0031650)2.71530329
70L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70763711
71positive regulation of B cell differentiation (GO:0045579)2.70228514
72positive regulation of interleukin-1 secretion (GO:0050716)2.68990576
73regulation of mast cell activation (GO:0033003)2.68449599
74positive regulation of chemokine biosynthetic process (GO:0045080)2.68087183
75protein polyglutamylation (GO:0018095)2.67968900
76regulation of T-helper 1 cell differentiation (GO:0045625)2.67430190
77positive regulation of amino acid transport (GO:0051957)2.66797176
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66468627
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65789581
80positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.65115177
81mitochondrial respiratory chain complex assembly (GO:0033108)2.65073073
82coenzyme catabolic process (GO:0009109)2.64999083
83G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64772263
84positive regulation of synapse assembly (GO:0051965)2.64496608
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64237054
86regulation of interleukin-1 beta secretion (GO:0050706)2.63696940
87establishment of melanosome localization (GO:0032401)2.61840643
88negative regulation of interleukin-17 production (GO:0032700)2.61669712
89methionine biosynthetic process (GO:0009086)2.61414666
90L-methionine salvage (GO:0071267)2.60933139
91L-methionine biosynthetic process (GO:0071265)2.60933139
92amino acid salvage (GO:0043102)2.60933139
93righting reflex (GO:0060013)2.60814234
94spinal cord association neuron differentiation (GO:0021527)2.59838130
95synaptic transmission, glutamatergic (GO:0035249)2.59009254
96neutrophil activation involved in immune response (GO:0002283)2.58443707
97hippocampus development (GO:0021766)2.58430885
98aspartate family amino acid biosynthetic process (GO:0009067)2.58350798
99regulation of NFAT protein import into nucleus (GO:0051532)2.58053444
100negative regulation of dendrite development (GO:2000171)2.57378597
101positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.57369441
102response to pheromone (GO:0019236)2.56239455
103regulation of activation of Janus kinase activity (GO:0010533)2.56186104
104dopamine transport (GO:0015872)2.56115337
105endosome to pigment granule transport (GO:0043485)2.55961262
106endosome to melanosome transport (GO:0035646)2.55961262
107production of molecular mediator involved in inflammatory response (GO:0002532)2.55530497
108response to host immune response (GO:0052572)2.55483095
109response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55483095
110histamine transport (GO:0051608)2.55285270
111establishment of pigment granule localization (GO:0051905)2.54341490
112regulation of inositol phosphate biosynthetic process (GO:0010919)2.53789996
113protein localization to cilium (GO:0061512)2.53695840
114phagosome maturation (GO:0090382)2.53176350
115alkaloid metabolic process (GO:0009820)2.53149516
116mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.52740177
117regulation of mast cell degranulation (GO:0043304)2.52268894
118positive regulation of protein homodimerization activity (GO:0090073)2.51211972
119melanosome transport (GO:0032402)2.50786505
120intraciliary transport (GO:0042073)2.50741586
121heparin metabolic process (GO:0030202)2.50309433
122heparin biosynthetic process (GO:0030210)2.50309433
123regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.50159959
124glycosphingolipid biosynthetic process (GO:0006688)2.49971724
125regulation of chemokine biosynthetic process (GO:0045073)2.49433372
126positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.48921310
127sympathetic nervous system development (GO:0048485)2.48854140
128negative regulation of heart rate (GO:0010459)2.48755540
129methionine metabolic process (GO:0006555)2.48625209
130regulation of synapse assembly (GO:0051963)2.47934319
131ubiquinone metabolic process (GO:0006743)2.47866705
132ubiquinone biosynthetic process (GO:0006744)2.47343028
133facial nerve structural organization (GO:0021612)2.45849080
134positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.45651595
135ribonucleoprotein complex disassembly (GO:0032988)2.45115340
136neurotransmitter biosynthetic process (GO:0042136)2.45029902
137oxidative demethylation (GO:0070989)2.43604376
138DNA integration (GO:0015074)2.43564156
139cellular ketone body metabolic process (GO:0046950)2.43542557
140pigment granule transport (GO:0051904)2.43448942
141protein-cofactor linkage (GO:0018065)2.43405038
142myeloid dendritic cell differentiation (GO:0043011)2.42981647
143T-helper 1 type immune response (GO:0042088)2.42977232
144central nervous system neuron axonogenesis (GO:0021955)2.42382260
145regulation of mast cell activation involved in immune response (GO:0033006)2.41981273
146positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.40481795
147mature B cell differentiation (GO:0002335)2.40085494
148B cell homeostasis (GO:0001782)2.39902476
149myeloid leukocyte mediated immunity (GO:0002444)2.39712570
150CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.39221825
151ganglion development (GO:0061548)2.38156452
152regulation of immunoglobulin secretion (GO:0051023)2.37462571
153ketone body metabolic process (GO:1902224)2.37205974
154synaptic vesicle maturation (GO:0016188)2.37160955
155cullin deneddylation (GO:0010388)2.36916620
156regulation of MHC class II biosynthetic process (GO:0045346)2.36028600
157organelle transport along microtubule (GO:0072384)2.35761047
158acrosome reaction (GO:0007340)2.35025359
159neuron-neuron synaptic transmission (GO:0007270)2.34638367
160myeloid dendritic cell activation (GO:0001773)2.34000789
161epithelial cilium movement (GO:0003351)2.32693698
162S-adenosylmethionine metabolic process (GO:0046500)2.31885592
163melanosome localization (GO:0032400)2.30411885
164de novo posttranslational protein folding (GO:0051084)2.29250017
165retinal cone cell development (GO:0046549)2.27814832
166vesicle localization (GO:0051648)2.27736439
167protein deneddylation (GO:0000338)2.25310221
168pigment granule localization (GO:0051875)2.24769815
169microtubule nucleation (GO:0007020)2.24587103
170dendrite morphogenesis (GO:0048813)2.23434528
171C4-dicarboxylate transport (GO:0015740)2.23387526
172epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.22250717
173cytoskeleton-dependent intracellular transport (GO:0030705)2.22179544
174platelet dense granule organization (GO:0060155)2.22069384
175substrate-independent telencephalic tangential migration (GO:0021826)2.21983940
176substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.21983940
177calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.20146845
178de novo protein folding (GO:0006458)2.19976234
179regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.18287285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.54132522
2GBX2_23144817_ChIP-Seq_PC3_Human4.18622568
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.80467262
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26249956
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.82183807
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71756402
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60362743
8VDR_22108803_ChIP-Seq_LS180_Human2.53612977
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.36079284
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32041016
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31509032
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30272784
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.29210436
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27575316
15TAF15_26573619_Chip-Seq_HEK293_Human2.19770064
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18556349
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18282516
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.16286069
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14090808
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13611739
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10835481
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08813025
23* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.06127076
24IGF1R_20145208_ChIP-Seq_DFB_Human2.04815419
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99648413
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99346527
27* P300_19829295_ChIP-Seq_ESCs_Human1.98687429
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96859411
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95659664
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.89580260
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89184890
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87721498
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86985945
34IRF1_19129219_ChIP-ChIP_H3396_Human1.85608789
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83781246
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83265175
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.77356328
38SCL_19346495_ChIP-Seq_HPC-7_Human1.69861041
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.68681223
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67829827
41* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66748507
42FUS_26573619_Chip-Seq_HEK293_Human1.64145208
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62637236
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.62520333
45* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.60018149
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55710341
47JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54300505
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.54048574
49EWS_26573619_Chip-Seq_HEK293_Human1.53801579
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.53289425
51* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52617989
52REST_21632747_ChIP-Seq_MESCs_Mouse1.52150547
53FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.52094406
54RNF2_27304074_Chip-Seq_NSC_Mouse1.49819652
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49222992
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49036444
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49036444
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47926050
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47810105
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47632528
61* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46643917
62RNF2_27304074_Chip-Seq_ESCs_Mouse1.45881970
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44798956
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43664868
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43070535
66ER_23166858_ChIP-Seq_MCF-7_Human1.42683506
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41656289
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.40404514
69SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39549983
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38251547
71ELK1_19687146_ChIP-ChIP_HELA_Human1.37687711
72* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.37388966
73HTT_18923047_ChIP-ChIP_STHdh_Human1.36786704
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36606214
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36489689
76* AR_25329375_ChIP-Seq_VCAP_Human1.35943551
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.35304766
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34412087
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.33730955
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32643861
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.32278109
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30887070
83* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29229393
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.27569319
85* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24588884
86BCAT_22108803_ChIP-Seq_LS180_Human1.23970060
87* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22316763
88IRF8_27001747_Chip-Seq_BMDM_Mouse1.21056390
89AR_21572438_ChIP-Seq_LNCaP_Human1.20175194
90* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19433796
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.18936264
92JUN_21703547_ChIP-Seq_K562_Human1.18846498
93CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18495631
94EZH2_27294783_Chip-Seq_ESCs_Mouse1.16165199
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14858143
96* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12396308
97ZNF274_21170338_ChIP-Seq_K562_Hela1.12328653
98TP53_18474530_ChIP-ChIP_U2OS_Human1.11281559
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10803716
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.10548486
101FLI1_27457419_Chip-Seq_LIVER_Mouse1.09642719
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09224030
103* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07797340
104SRF_21415370_ChIP-Seq_HL-1_Mouse1.07617985
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.07388361
106STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.05788543
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05343764
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04810942
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04431801
110CBP_20019798_ChIP-Seq_JUKART_Human1.04431801
111MYC_18940864_ChIP-ChIP_HL60_Human1.04238407
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03581783
113* REST_18959480_ChIP-ChIP_MESCs_Mouse1.03248017
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03092179
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02566637
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02023083
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02023083
118VDR_23849224_ChIP-Seq_CD4+_Human1.01350808
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00271342
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99309895
121TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99208862
122P53_22387025_ChIP-Seq_ESCs_Mouse0.98990986
123* SOX2_21211035_ChIP-Seq_LN229_Gbm0.98739307
124* TCF4_23295773_ChIP-Seq_U87_Human0.98474328
125TP53_22573176_ChIP-Seq_HFKS_Human0.98172907
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98010690
127* STAT3_23295773_ChIP-Seq_U87_Human0.97786804
128PRDM14_20953172_ChIP-Seq_ESCs_Human0.97591577
129TCF4_22108803_ChIP-Seq_LS180_Human0.96146484
130* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96052291
131RUNX2_22187159_ChIP-Seq_PCA_Human0.95646764
132* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95425707
133THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95053642
134CMYC_18555785_Chip-Seq_ESCs_Mouse0.94906251
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.94724969
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94507852
137SOX2_19829295_ChIP-Seq_ESCs_Human0.92144364
138NANOG_19829295_ChIP-Seq_ESCs_Human0.92144364
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90814342
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90487118
141EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90455574
142* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89140002
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86297164
144MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85655564
145NCOR_22424771_ChIP-Seq_293T_Human0.83800566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.23602839
2MP0006292_abnormal_olfactory_placode3.67989216
3MP0004859_abnormal_synaptic_plasticity3.20989965
4MP0003880_abnormal_central_pattern2.97714600
5MP0004510_myositis2.75762847
6MP0002736_abnormal_nociception_after2.63549297
7MP0003787_abnormal_imprinting2.62064072
8MP0008875_abnormal_xenobiotic_pharmacok2.55463163
9MP0009785_altered_susceptibility_to2.49629875
10MP0001835_abnormal_antigen_presentation2.48462261
11MP0002735_abnormal_chemical_nociception2.41083628
12MP0001968_abnormal_touch/_nociception2.39958412
13MP0010386_abnormal_urinary_bladder2.39156311
14MP0002063_abnormal_learning/memory/cond2.35396172
15MP0001501_abnormal_sleep_pattern2.23213927
16MP0002638_abnormal_pupillary_reflex2.20595018
17MP0006276_abnormal_autonomic_nervous2.19677271
18MP0003635_abnormal_synaptic_transmissio2.18180820
19MP0003436_decreased_susceptibility_to2.14849093
20MP0009745_abnormal_behavioral_response2.08582122
21MP0002822_catalepsy2.06418969
22MP0002148_abnormal_hypersensitivity_rea2.03153776
23MP0005174_abnormal_tail_pigmentation1.90907096
24MP0003121_genomic_imprinting1.88831114
25MP0003303_peritoneal_inflammation1.83047727
26MP0002572_abnormal_emotion/affect_behav1.81940991
27MP0005187_abnormal_penis_morphology1.76680750
28MP0002102_abnormal_ear_morphology1.72834189
29MP0000015_abnormal_ear_pigmentation1.69876298
30MP0005025_abnormal_response_to1.67482970
31MP0002837_dystrophic_cardiac_calcinosis1.65503776
32MP0003724_increased_susceptibility_to1.65206359
33MP0002419_abnormal_innate_immunity1.64581008
34MP0001502_abnormal_circadian_rhythm1.61660922
35MP0002064_seizures1.60175567
36MP0003122_maternal_imprinting1.60164808
37MP0009697_abnormal_copulation1.59441505
38MP0000778_abnormal_nervous_system1.58624141
39MP0002938_white_spotting1.57593572
40MP0005171_absent_coat_pigmentation1.53660007
41MP0005000_abnormal_immune_tolerance1.53183037
42MP0003195_calcinosis1.53074849
43MP0005646_abnormal_pituitary_gland1.52634528
44MP0009764_decreased_sensitivity_to1.51445501
45MP0005645_abnormal_hypothalamus_physiol1.49671323
46MP0001529_abnormal_vocalization1.49421975
47MP0003656_abnormal_erythrocyte_physiolo1.46372381
48MP0004145_abnormal_muscle_electrophysio1.45644071
49MP0000685_abnormal_immune_system1.45010362
50MP0004142_abnormal_muscle_tone1.44831150
51MP0005253_abnormal_eye_physiology1.44727444
52MP0001348_abnormal_lacrimal_gland1.43326356
53MP0002184_abnormal_innervation1.42254389
54MP0001984_abnormal_olfaction1.42244140
55MP0003646_muscle_fatigue1.42018593
56MP0004084_abnormal_cardiac_muscle1.39139834
57MP0002733_abnormal_thermal_nociception1.38493202
58MP0006035_abnormal_mitochondrial_morpho1.37485264
59MP0005551_abnormal_eye_electrophysiolog1.34967431
60MP0004215_abnormal_myocardial_fiber1.33172174
61MP0008872_abnormal_physiological_respon1.33114736
62MP0005671_abnormal_response_to1.31342071
63MP0004130_abnormal_muscle_cell1.30789557
64MP0005397_hematopoietic_system_phenotyp1.30498968
65MP0001545_abnormal_hematopoietic_system1.30498968
66MP0002557_abnormal_social/conspecific_i1.29700436
67MP0008877_abnormal_DNA_methylation1.29676310
68MP0005464_abnormal_platelet_physiology1.28276008
69MP0003718_maternal_effect1.28039856
70MP0008995_early_reproductive_senescence1.27891371
71MP0009046_muscle_twitch1.27881002
72MP0006036_abnormal_mitochondrial_physio1.26024130
73MP0002452_abnormal_antigen_presenting1.25966120
74MP0002067_abnormal_sensory_capabilities1.24134881
75MP0002095_abnormal_skin_pigmentation1.23059497
76MP0000955_abnormal_spinal_cord1.20376236
77MP0005075_abnormal_melanosome_morpholog1.19961979
78MP0002723_abnormal_immune_serum1.19889515
79MP0001188_hyperpigmentation1.19803614
80MP0001800_abnormal_humoral_immune1.19264581
81MP0006082_CNS_inflammation1.18820881
82MP0008775_abnormal_heart_ventricle1.18464323
83MP0004811_abnormal_neuron_physiology1.17044723
84MP0001440_abnormal_grooming_behavior1.16845168
85MP0004808_abnormal_hematopoietic_stem1.16799096
86MP0002751_abnormal_autonomic_nervous1.16033560
87MP0003123_paternal_imprinting1.15319680
88MP0001970_abnormal_pain_threshold1.14927810
89MP0002876_abnormal_thyroid_physiology1.14127722
90MP0005386_behavior/neurological_phenoty1.13732739
91MP0004924_abnormal_behavior1.13732739
92MP0004085_abnormal_heartbeat1.13686903
93MP0002882_abnormal_neuron_morphology1.11902968
94MP0005084_abnormal_gallbladder_morpholo1.11893470
95MP0008058_abnormal_DNA_repair1.10509629
96MP0001819_abnormal_immune_cell1.10347505
97MP0002420_abnormal_adaptive_immunity1.08398803
98MP0003172_abnormal_lysosome_physiology1.05900303
99MP0002909_abnormal_adrenal_gland1.05412864
100MP0008789_abnormal_olfactory_epithelium1.04928580
101MP0006072_abnormal_retinal_apoptosis1.02593766
102MP0005410_abnormal_fertilization0.97189734
103MP0002752_abnormal_somatic_nervous0.96431951
104MP0002229_neurodegeneration0.95675092
105MP0005387_immune_system_phenotype0.95021509
106MP0001790_abnormal_immune_system0.95021509
107MP0002653_abnormal_ependyma_morphology0.95010775
108MP0000681_abnormal_thyroid_gland0.94198791
109MP0002398_abnormal_bone_marrow0.93760757
110MP0002160_abnormal_reproductive_system0.93291758
111MP0002277_abnormal_respiratory_mucosa0.92993032
112MP0004270_analgesia0.90545080
113MP0003011_delayed_dark_adaptation0.89902777
114MP0001533_abnormal_skeleton_physiology0.89837719
115MP0002066_abnormal_motor_capabilities/c0.89586859
116MP0005423_abnormal_somatic_nervous0.89131960
117MP0005394_taste/olfaction_phenotype0.88019912
118MP0005499_abnormal_olfactory_system0.88019912
119MP0003806_abnormal_nucleotide_metabolis0.87894500
120MP0004484_altered_response_of0.85837244
121MP0002332_abnormal_exercise_endurance0.83259500
122MP0004036_abnormal_muscle_relaxation0.82118988
123MP0002139_abnormal_hepatobiliary_system0.81445546
124MP0000538_abnormal_urinary_bladder0.80763620
125MP0005448_abnormal_energy_balance0.80597870
126MP0002069_abnormal_eating/drinking_beha0.80052948
127MP0000716_abnormal_immune_system0.79410673
128MP0005085_abnormal_gallbladder_physiolo0.79041000
129MP0002090_abnormal_vision0.78254104
130MP0001764_abnormal_homeostasis0.78142335
131MP0005408_hypopigmentation0.77764881
132MP0003698_abnormal_male_reproductive0.77544255
133MP0002234_abnormal_pharynx_morphology0.76899595
134MP0001845_abnormal_inflammatory_respons0.76446075
135MP0000647_abnormal_sebaceous_gland0.76414135
136MP0004742_abnormal_vestibular_system0.75424023
137MP0002272_abnormal_nervous_system0.74053330
138MP0003186_abnormal_redox_activity0.73624700
139MP0003221_abnormal_cardiomyocyte_apopto0.73523836
140MP0002152_abnormal_brain_morphology0.72818575
141MP0009278_abnormal_bone_marrow0.72701658
142MP0000372_irregular_coat_pigmentation0.71426130
143MP0002006_tumorigenesis0.71277139
144MP0001905_abnormal_dopamine_level0.69751509
145MP0005257_abnormal_intraocular_pressure0.69440333
146MP0001486_abnormal_startle_reflex0.68017810
147MP0008961_abnormal_basal_metabolism0.67724202
148MP0000631_abnormal_neuroendocrine_gland0.66211529
149MP0004147_increased_porphyrin_level0.65544464
150MP0002734_abnormal_mechanical_nocicepti0.63888274
151MP0002429_abnormal_blood_cell0.63156025

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.24714079
2Optic neuritis (HP:0100653)4.09410282
3Retrobulbar optic neuritis (HP:0100654)4.09410282
4Epileptic encephalopathy (HP:0200134)4.08337361
5Focal motor seizures (HP:0011153)4.02541254
6Protruding tongue (HP:0010808)4.02016642
7Recurrent gram-negative bacterial infections (HP:0005420)3.99952001
8Recurrent bacterial skin infections (HP:0005406)3.96741593
9Recurrent abscess formation (HP:0002722)3.88608491
10Mediastinal lymphadenopathy (HP:0100721)3.70323632
11Tented upper lip vermilion (HP:0010804)3.66973936
12Febrile seizures (HP:0002373)3.64468149
13Abnormal hair whorl (HP:0010721)3.61353360
14Myositis (HP:0100614)3.46744257
15Orchitis (HP:0100796)3.42239292
16Hyperventilation (HP:0002883)3.36904702
17Cortical dysplasia (HP:0002539)3.32278850
18Limb dystonia (HP:0002451)3.29375972
19Acute necrotizing encephalopathy (HP:0006965)3.27502717
20Progressive inability to walk (HP:0002505)3.16708569
21Acute encephalopathy (HP:0006846)3.10647694
22Polyphagia (HP:0002591)3.07233065
23Abnormal mitochondria in muscle tissue (HP:0008316)3.04684401
24Pachygyria (HP:0001302)2.98074829
25Fair hair (HP:0002286)2.97893342
26Generalized aminoaciduria (HP:0002909)2.87061773
27Poor eye contact (HP:0000817)2.86783118
28Progressive macrocephaly (HP:0004481)2.86502708
29Eczematoid dermatitis (HP:0000976)2.79984738
30Mitochondrial inheritance (HP:0001427)2.78155464
31Renal Fanconi syndrome (HP:0001994)2.72995512
32Broad-based gait (HP:0002136)2.69960789
33Blue irides (HP:0000635)2.64417704
34Gingivitis (HP:0000230)2.64271054
35Increased CSF lactate (HP:0002490)2.63124619
36Abnormality of the labia minora (HP:0012880)2.61666673
37Drooling (HP:0002307)2.61146039
38Excessive salivation (HP:0003781)2.61146039
39Lipid accumulation in hepatocytes (HP:0006561)2.59894751
40Elevated erythrocyte sedimentation rate (HP:0003565)2.58353811
41Medial flaring of the eyebrow (HP:0010747)2.56336279
42Retinal dysplasia (HP:0007973)2.55914650
43Abnormality of the hip-girdle musculature (HP:0001445)2.54197122
44Abnormality of the musculature of the pelvis (HP:0001469)2.54197122
45Hepatic necrosis (HP:0002605)2.53839941
46Heterochromia iridis (HP:0001100)2.51271607
47Generalized hypopigmentation of hair (HP:0011358)2.50376679
48Stomatitis (HP:0010280)2.49990879
49Urinary urgency (HP:0000012)2.49779030
50Increased hepatocellular lipid droplets (HP:0006565)2.46724541
51Palpebral edema (HP:0100540)2.46441670
52Aplasia/Hypoplasia of the brainstem (HP:0007362)2.45640609
53Hypoplasia of the brainstem (HP:0002365)2.45640609
54Lissencephaly (HP:0001339)2.43852871
55Hepatocellular necrosis (HP:0001404)2.42514188
56Prolonged bleeding time (HP:0003010)2.39365311
57Absent speech (HP:0001344)2.37882684
58Cerebral edema (HP:0002181)2.33375334
59Abnormal social behavior (HP:0012433)2.32380312
60Impaired social interactions (HP:0000735)2.32380312
61Arterial thrombosis (HP:0004420)2.31130701
62Pulmonary infiltrates (HP:0002113)2.30839066
63Hyperglycinemia (HP:0002154)2.30835331
64Focal seizures (HP:0007359)2.30657381
65Epileptiform EEG discharges (HP:0011182)2.30335514
66Increased IgM level (HP:0003496)2.30046488
67Congenital primary aphakia (HP:0007707)2.28309301
68Failure to thrive in infancy (HP:0001531)2.27938164
69Inability to walk (HP:0002540)2.27900331
70Muscular hypotonia of the trunk (HP:0008936)2.22415329
71Prostate neoplasm (HP:0100787)2.22115862
72Keratoconjunctivitis sicca (HP:0001097)2.21964485
73Chest pain (HP:0100749)2.21014845
74Pancreatic cysts (HP:0001737)2.20413443
75Abnormality of the heme biosynthetic pathway (HP:0010472)2.18396808
76Hypothermia (HP:0002045)2.17499380
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.17044702
78Absent/shortened dynein arms (HP:0200106)2.17044702
79Asymmetry of the thorax (HP:0001555)2.15313058
80Inappropriate behavior (HP:0000719)2.14979303
81Exotropia (HP:0000577)2.13642912
82Chronic obstructive pulmonary disease (HP:0006510)2.12864367
83Obstructive lung disease (HP:0006536)2.12864367
84EEG with generalized epileptiform discharges (HP:0011198)2.11019832
85Tubulointerstitial nephritis (HP:0001970)2.09765635
86Hypsarrhythmia (HP:0002521)2.09733220
87Pancreatic fibrosis (HP:0100732)2.08876633
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08333680
89Vasculitis (HP:0002633)2.07776726
90Nephronophthisis (HP:0000090)2.07482984
91Large eyes (HP:0001090)2.06227353
92Esotropia (HP:0000565)2.05701162
93Type II lissencephaly (HP:0007260)2.04114789
94Widely spaced teeth (HP:0000687)2.04096208
95Poor suck (HP:0002033)2.03191887
96Gastrointestinal infarctions (HP:0005244)2.02343970
97Spastic tetraplegia (HP:0002510)2.01738171
98Keratoconjunctivitis (HP:0001096)2.00545906
99Abnormality of urine glucose concentration (HP:0011016)2.00127969
100Glycosuria (HP:0003076)2.00127969
101Increased intramyocellular lipid droplets (HP:0012240)1.98920608
102Polymicrogyria (HP:0002126)1.98318788
103Astrocytoma (HP:0009592)1.97652233
104Abnormality of the astrocytes (HP:0100707)1.97652233
105Amyotrophic lateral sclerosis (HP:0007354)1.97426239
106Chronic hepatic failure (HP:0100626)1.95889125
107Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95390328
108Renal cortical cysts (HP:0000803)1.95180165
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94891306
110Abnormality of alanine metabolism (HP:0010916)1.94891306
111Hyperalaninemia (HP:0003348)1.94891306
112Progressive cerebellar ataxia (HP:0002073)1.94585003
113Gingival bleeding (HP:0000225)1.92274249
114Recurrent skin infections (HP:0001581)1.91579554
115Shoulder girdle muscle weakness (HP:0003547)1.91049053
116Abnormality of DNA repair (HP:0003254)1.90492189
117Open mouth (HP:0000194)1.89682035
118Abnormality of salivation (HP:0100755)1.89611150
119Lactic acidosis (HP:0003128)1.89367108
120Amblyopia (HP:0000646)1.89230823
121Atonic seizures (HP:0010819)1.88954039
122Rimmed vacuoles (HP:0003805)1.88833726
123Thyroid-stimulating hormone excess (HP:0002925)1.88519012
124Increased serum lactate (HP:0002151)1.88287642
125Myokymia (HP:0002411)1.87585207
126Decreased central vision (HP:0007663)1.87429271
127Genital tract atresia (HP:0001827)1.87039393
128Abnormality of the prostate (HP:0008775)1.86099663
129Abnormality of glycolysis (HP:0004366)1.85879941
130Alveolar cell carcinoma (HP:0006519)1.84419525
131Keratitis (HP:0000491)1.84103510
132White forelock (HP:0002211)1.83777462
133Neoplasm of head and neck (HP:0012288)1.83764004
134Esophageal neoplasm (HP:0100751)1.83764004
135Thrombocytosis (HP:0001894)1.83722651
136Cholecystitis (HP:0001082)1.83327718
137Abnormal gallbladder physiology (HP:0012438)1.83327718
138Hemoptysis (HP:0002105)1.82704336
139Hemiparesis (HP:0001269)1.82162501
140Sporadic (HP:0003745)1.81777271
141Abnormality of macrophages (HP:0004311)1.81586127
142Neurodegeneration (HP:0002180)1.80777679
143Acanthocytosis (HP:0001927)1.80562874
144Abnormality of the intervertebral disk (HP:0005108)1.80243621
145True hermaphroditism (HP:0010459)1.79950256
146Akinesia (HP:0002304)1.79759032
147Decreased muscle mass (HP:0003199)1.79758420
148Hip dysplasia (HP:0001385)1.79671880
149Gaze-evoked nystagmus (HP:0000640)1.79550335
150Optic disc pallor (HP:0000543)1.78830902
151Specific learning disability (HP:0001328)1.77730475
152Meningitis (HP:0001287)1.76830714
153Gait imbalance (HP:0002141)1.75967988
154Synophrys (HP:0000664)1.75776255
155Increased muscle lipid content (HP:0009058)1.75399345
156Papillary thyroid carcinoma (HP:0002895)1.74363146
157Cerebral hypomyelination (HP:0006808)1.74298601
158Optic nerve coloboma (HP:0000588)1.73575189
159Methylmalonic acidemia (HP:0002912)1.72879929
160Exertional dyspnea (HP:0002875)1.72183201
161Vaginal atresia (HP:0000148)1.71767898
162Nephrogenic diabetes insipidus (HP:0009806)1.71084137
163Abnormality of the renal medulla (HP:0100957)1.69846455
164Bile duct proliferation (HP:0001408)1.69829752
165Abnormal biliary tract physiology (HP:0012439)1.69829752
166Abnormal respiratory motile cilium morphology (HP:0005938)1.69612511
167Abnormal respiratory epithelium morphology (HP:0012253)1.69612511
168Sleep apnea (HP:0010535)1.69525905
169Cerebellar dysplasia (HP:0007033)1.68720736
170Abnormality of macular pigmentation (HP:0008002)1.68496693
171Periodontitis (HP:0000704)1.68366114
172Limb-girdle muscle atrophy (HP:0003797)1.67988569
173Acute lymphatic leukemia (HP:0006721)1.67833975
174Abnormal ciliary motility (HP:0012262)1.67823559
175Abnormality of the fingertips (HP:0001211)1.67694262
176Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66788990
177Hypophosphatemic rickets (HP:0004912)1.65786211
178Large for gestational age (HP:0001520)1.64895170
179Abnormality of lateral ventricle (HP:0030047)1.63894791
180Abolished electroretinogram (ERG) (HP:0000550)1.63872440
181Upper limb muscle weakness (HP:0003484)1.63638164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.52258128
2RIPK43.81283600
3CASK3.80106941
4MAP2K73.58443980
5MARK13.21801642
6NTRK23.16014224
7EIF2AK13.01503746
8WNK32.61617043
9MAP3K122.55232329
10MAP4K22.46089421
11PINK12.45843061
12SIK22.39810539
13TRIM282.39319876
14MAP3K42.32626111
15NTRK32.11891925
16CSNK1G32.11233277
17CSNK1A1L2.07206951
18MAP3K62.01913803
19FRK1.98052333
20TBK11.97816371
21PBK1.95338753
22CSNK1G21.92846527
23EIF2AK31.92089485
24TNIK1.88730405
25MAP3K141.85421781
26AKT31.84479826
27ACVR1B1.84467792
28IRAK41.77793098
29YES11.74929803
30EPHA31.68486504
31BMPR1B1.68405037
32BRD41.67113826
33BCKDK1.65821299
34PRKD31.63793414
35MAP2K41.60596469
36CSNK1G11.60324900
37MAPK131.54141626
38STK161.52181214
39ERBB31.50118262
40PAK31.47299179
41STK38L1.45207151
42MUSK1.44159750
43TXK1.39294812
44ADRBK21.35445964
45PLK21.33663683
46DAPK11.32411059
47JAK31.26180997
48DYRK21.26094646
49BLK1.25355646
50SRPK11.24040228
51DYRK31.23622036
52MINK11.23115855
53BMPR21.18779316
54KIT1.18660414
55EPHA41.16990600
56GRK11.13049145
57MAP3K51.10872376
58DAPK21.09666591
59MATK1.06571526
60CDK191.06007261
61FES1.04299416
62MST41.04148649
63PIM21.03117463
64CAMKK21.03049664
65SYK1.02676412
66MYLK0.99622875
67KSR10.99592739
68BCR0.98369166
69OBSCN0.93006417
70IKBKE0.90044667
71GRK70.87841264
72PRPF4B0.87155173
73IRAK20.85527702
74EIF2AK20.85507583
75NME10.84354021
76BTK0.84204951
77IKBKB0.84204360
78CSF1R0.84028126
79LIMK10.80620457
80VRK10.77982057
81SGK20.77397611
82CCNB10.75669023
83FER0.75459540
84TSSK60.74862169
85MAPKAPK50.70406587
86TAOK30.69078426
87RPS6KA50.68343200
88FGR0.64983685
89ADRBK10.64655146
90ZAP700.64551418
91PHKG20.64447951
92PHKG10.64447951
93CHUK0.64435944
94ERBB40.64190380
95LYN0.63663020
96RPS6KA20.63237322
97RPS6KB10.62821157
98PKN20.61848194
99JAK20.61712960
100MAPK40.60374568
101CDK50.60107345
102SIK10.57794479
103PDK20.54930159
104NEK10.54092592
105PKN10.52906945
106TGFBR10.52416228
107SGK2230.52409768
108SGK4940.52409768
109TESK10.49629482
110PLK30.48937035
111VRK20.47471354
112STK390.47235322
113CDK140.47060219
114PRKAA10.45918007
115CSNK1A10.44379689
116PRKCG0.43863333
117SGK30.43847362
118CAMK2A0.43846390
119HCK0.41715828
120INSRR0.41688751
121IRAK10.41118638
122STK240.39727086
123PRKCE0.39668306
124CDK30.38702098
125CAMK2G0.36656796
126WNK40.35649010
127CSNK1E0.35619421
128DYRK1A0.35456580
129PAK60.35323514
130TLK10.34910562
131NUAK10.33309326
132DAPK30.32825752
133CAMK2B0.32807406
134MKNK20.32191820
135PRKACA0.31863440
136PRKCD0.31614955
137PRKG10.31111052
138MARK30.29733852
139TEC0.29317017
140UHMK10.28901531
141FLT30.28209478
142SGK10.28156381
143ATR0.27879827
144FYN0.27076741
145CDK180.26132642
146AKT20.25575620
147DDR20.25557891
148RPS6KA60.23127770
149PRKCZ0.22331027
150RPS6KC10.21969277
151RPS6KL10.21969277
152ABL10.21835791
153ZAK0.21419144
154GRK50.21161216
155PTK2B0.20743607
156LCK0.19823751
157PIM10.19771119

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.16607004
2Protein export_Homo sapiens_hsa030602.63683697
3Steroid biosynthesis_Homo sapiens_hsa001002.59736377
4Type I diabetes mellitus_Homo sapiens_hsa049402.43089563
5Oxidative phosphorylation_Homo sapiens_hsa001902.40664183
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.38143315
7Butanoate metabolism_Homo sapiens_hsa006502.35368904
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26120878
9Parkinsons disease_Homo sapiens_hsa050122.24220316
10Graft-versus-host disease_Homo sapiens_hsa053322.23735197
11Leishmaniasis_Homo sapiens_hsa051402.17254962
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11555603
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04872448
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03829363
15African trypanosomiasis_Homo sapiens_hsa051432.01925358
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92344169
17Allograft rejection_Homo sapiens_hsa053301.86998343
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81404705
19Rheumatoid arthritis_Homo sapiens_hsa053231.77844482
20Morphine addiction_Homo sapiens_hsa050321.72078757
21Propanoate metabolism_Homo sapiens_hsa006401.72065825
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.68487013
23Circadian entrainment_Homo sapiens_hsa047131.66827600
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63836160
25TNF signaling pathway_Homo sapiens_hsa046681.62298686
26Measles_Homo sapiens_hsa051621.60316648
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59601222
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.59365643
29Pertussis_Homo sapiens_hsa051331.59204913
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58842631
31Selenocompound metabolism_Homo sapiens_hsa004501.58037857
32Fatty acid elongation_Homo sapiens_hsa000621.56480103
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55480544
34GABAergic synapse_Homo sapiens_hsa047271.55411635
35Phagosome_Homo sapiens_hsa041451.54645538
36Collecting duct acid secretion_Homo sapiens_hsa049661.53067861
37Tuberculosis_Homo sapiens_hsa051521.52455736
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51538468
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47668784
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.47534410
41Serotonergic synapse_Homo sapiens_hsa047261.47201434
42Legionellosis_Homo sapiens_hsa051341.46167852
43Phototransduction_Homo sapiens_hsa047441.46025713
44Osteoclast differentiation_Homo sapiens_hsa043801.45311583
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.45284201
46Asthma_Homo sapiens_hsa053101.44928899
47Glutamatergic synapse_Homo sapiens_hsa047241.43773000
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41964341
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.39861087
50Influenza A_Homo sapiens_hsa051641.39128642
51Caffeine metabolism_Homo sapiens_hsa002321.38626507
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38126712
53Synaptic vesicle cycle_Homo sapiens_hsa047211.38084710
54Proteasome_Homo sapiens_hsa030501.37771402
55Basal transcription factors_Homo sapiens_hsa030221.36476575
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36380251
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.35896982
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31415046
59Huntingtons disease_Homo sapiens_hsa050161.30668924
60beta-Alanine metabolism_Homo sapiens_hsa004101.26863121
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24037623
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23799408
63Alzheimers disease_Homo sapiens_hsa050101.23601317
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23350820
65Tyrosine metabolism_Homo sapiens_hsa003501.22708017
66Salmonella infection_Homo sapiens_hsa051321.19996152
67Malaria_Homo sapiens_hsa051441.18208314
68RNA polymerase_Homo sapiens_hsa030201.15613656
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14130904
70Long-term depression_Homo sapiens_hsa047301.13797757
71Neurotrophin signaling pathway_Homo sapiens_hsa047221.12716650
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10564676
73Shigellosis_Homo sapiens_hsa051311.10495537
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10161264
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10155781
76Dopaminergic synapse_Homo sapiens_hsa047281.09873557
77Chemokine signaling pathway_Homo sapiens_hsa040621.08334978
78Hematopoietic cell lineage_Homo sapiens_hsa046401.07535567
79Tryptophan metabolism_Homo sapiens_hsa003801.06422766
80Cholinergic synapse_Homo sapiens_hsa047251.04848235
81Jak-STAT signaling pathway_Homo sapiens_hsa046301.04156717
82Intestinal immune network for IgA production_Homo sapiens_hsa046721.04027566
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01209615
84B cell receptor signaling pathway_Homo sapiens_hsa046621.01010367
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00773098
86Peroxisome_Homo sapiens_hsa041460.99891636
87Linoleic acid metabolism_Homo sapiens_hsa005910.99513302
88Herpes simplex infection_Homo sapiens_hsa051680.98720186
89Chemical carcinogenesis_Homo sapiens_hsa052040.98458753
90Viral myocarditis_Homo sapiens_hsa054160.98455054
91Toxoplasmosis_Homo sapiens_hsa051450.98125784
92Phenylalanine metabolism_Homo sapiens_hsa003600.97265638
93Taste transduction_Homo sapiens_hsa047420.96185391
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95938152
95Alcoholism_Homo sapiens_hsa050340.95868812
96Acute myeloid leukemia_Homo sapiens_hsa052210.93436380
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93278258
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92966877
99Hepatitis B_Homo sapiens_hsa051610.92944826
100Sulfur metabolism_Homo sapiens_hsa009200.92324352
101Pyruvate metabolism_Homo sapiens_hsa006200.91024079
102Cardiac muscle contraction_Homo sapiens_hsa042600.90725798
103ErbB signaling pathway_Homo sapiens_hsa040120.90446549
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.90280745
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90044002
106Prolactin signaling pathway_Homo sapiens_hsa049170.89710810
107Staphylococcus aureus infection_Homo sapiens_hsa051500.89558244
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88860171
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88780997
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88629106
111Fatty acid metabolism_Homo sapiens_hsa012120.88562370
112Long-term potentiation_Homo sapiens_hsa047200.87880425
113Olfactory transduction_Homo sapiens_hsa047400.87339044
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82557173
115Type II diabetes mellitus_Homo sapiens_hsa049300.81915441
1162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81099566
117Retinol metabolism_Homo sapiens_hsa008300.80286792
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79573708
119Calcium signaling pathway_Homo sapiens_hsa040200.79573025
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78393025
121Regulation of autophagy_Homo sapiens_hsa041400.77768545
122Axon guidance_Homo sapiens_hsa043600.76394189
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75037226
124Metabolic pathways_Homo sapiens_hsa011000.74524308
125Circadian rhythm_Homo sapiens_hsa047100.74095799
126Autoimmune thyroid disease_Homo sapiens_hsa053200.72700142
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72240551
128Oxytocin signaling pathway_Homo sapiens_hsa049210.71209016
129Arginine and proline metabolism_Homo sapiens_hsa003300.70617412
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.67914458
131Apoptosis_Homo sapiens_hsa042100.66589463
132Fanconi anemia pathway_Homo sapiens_hsa034600.64842951
133Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64445885
134Platelet activation_Homo sapiens_hsa046110.63849155
135Colorectal cancer_Homo sapiens_hsa052100.62810005
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62063080
137Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62025756
138Arginine biosynthesis_Homo sapiens_hsa002200.61785862
139Renin secretion_Homo sapiens_hsa049240.60838275
140alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60120832
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59372979
142Vitamin B6 metabolism_Homo sapiens_hsa007500.58507128
143Glutathione metabolism_Homo sapiens_hsa004800.56701748
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55100025
145Purine metabolism_Homo sapiens_hsa002300.53598823
146Pyrimidine metabolism_Homo sapiens_hsa002400.52357210
147Cocaine addiction_Homo sapiens_hsa050300.50967908
148Hepatitis C_Homo sapiens_hsa051600.50805435
149T cell receptor signaling pathway_Homo sapiens_hsa046600.50096921
150Mineral absorption_Homo sapiens_hsa049780.49594329
151Vibrio cholerae infection_Homo sapiens_hsa051100.49117562
152Amphetamine addiction_Homo sapiens_hsa050310.48480935
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47519847
154GnRH signaling pathway_Homo sapiens_hsa049120.47355836
155Fatty acid degradation_Homo sapiens_hsa000710.46920809
156N-Glycan biosynthesis_Homo sapiens_hsa005100.45889333
157Oocyte meiosis_Homo sapiens_hsa041140.45623895
158Endometrial cancer_Homo sapiens_hsa052130.44653876
159RNA transport_Homo sapiens_hsa030130.43728278
160Ether lipid metabolism_Homo sapiens_hsa005650.43604763
161cAMP signaling pathway_Homo sapiens_hsa040240.43082195
162Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42708417
163Gap junction_Homo sapiens_hsa045400.42533153
164Salivary secretion_Homo sapiens_hsa049700.42362448
165Estrogen signaling pathway_Homo sapiens_hsa049150.40571835
166Glioma_Homo sapiens_hsa052140.38491131
167Sphingolipid metabolism_Homo sapiens_hsa006000.38114173
168Chronic myeloid leukemia_Homo sapiens_hsa052200.37494641
169Insulin secretion_Homo sapiens_hsa049110.37179631
170Biosynthesis of amino acids_Homo sapiens_hsa012300.37149239
171Carbon metabolism_Homo sapiens_hsa012000.34301038
172Non-homologous end-joining_Homo sapiens_hsa034500.34169765

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