ST8SIA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.43315977
2synaptic vesicle maturation (GO:0016188)5.06939296
3locomotory exploration behavior (GO:0035641)5.01952088
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.96407749
5pyrimidine nucleobase catabolic process (GO:0006208)4.81288590
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.73580860
7vocalization behavior (GO:0071625)4.65104131
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51111353
9glutamate secretion (GO:0014047)4.48302778
10ionotropic glutamate receptor signaling pathway (GO:0035235)4.36807027
11regulation of synaptic vesicle exocytosis (GO:2000300)4.36680224
12synaptic vesicle exocytosis (GO:0016079)4.35713130
13regulation of glutamate receptor signaling pathway (GO:1900449)4.22103786
14protein localization to synapse (GO:0035418)4.17876113
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.16209030
16behavioral response to nicotine (GO:0035095)4.08325009
17response to pheromone (GO:0019236)4.08250255
18neuron cell-cell adhesion (GO:0007158)4.01937416
19cellular potassium ion homeostasis (GO:0030007)3.96934985
20nucleobase catabolic process (GO:0046113)3.91842378
21neuronal action potential propagation (GO:0019227)3.89482537
22neurotransmitter secretion (GO:0007269)3.89071660
23synaptic transmission, glutamatergic (GO:0035249)3.86647181
24cerebellar Purkinje cell differentiation (GO:0021702)3.85501517
25regulation of synaptic vesicle transport (GO:1902803)3.85313826
26exploration behavior (GO:0035640)3.85259395
27glutamate receptor signaling pathway (GO:0007215)3.83935581
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.77533042
29neuron-neuron synaptic transmission (GO:0007270)3.72372191
30regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.70590474
31dendritic spine morphogenesis (GO:0060997)3.66770379
32glycine transport (GO:0015816)3.55500895
33limb bud formation (GO:0060174)3.53922286
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.53705054
35long-term memory (GO:0007616)3.52966983
36retinal cone cell development (GO:0046549)3.50940144
37positive regulation of membrane potential (GO:0045838)3.49343598
38nonmotile primary cilium assembly (GO:0035058)3.48218584
39neurotransmitter transport (GO:0006836)3.47305388
40regulation of neuronal synaptic plasticity (GO:0048168)3.47075235
41sodium ion export (GO:0071436)3.46274360
42gamma-aminobutyric acid transport (GO:0015812)3.45870604
43proline transport (GO:0015824)3.41192102
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.37454792
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31065868
46retinal ganglion cell axon guidance (GO:0031290)3.30406877
47L-amino acid import (GO:0043092)3.29835759
48gamma-aminobutyric acid signaling pathway (GO:0007214)3.29009924
49layer formation in cerebral cortex (GO:0021819)3.28879292
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22498145
51regulation of postsynaptic membrane potential (GO:0060078)3.22493402
52protein polyglutamylation (GO:0018095)3.22088011
53somite development (GO:0061053)3.22055085
54neuron recognition (GO:0008038)3.21383763
55dendrite morphogenesis (GO:0048813)3.19980865
56synaptic vesicle endocytosis (GO:0048488)3.19044560
57regulation of neurotransmitter secretion (GO:0046928)3.19037885
58regulation of rhodopsin mediated signaling pathway (GO:0022400)3.16827856
59cerebral cortex radially oriented cell migration (GO:0021799)3.16827166
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.13950047
61rhodopsin mediated signaling pathway (GO:0016056)3.13758668
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13505289
63membrane hyperpolarization (GO:0060081)3.12823400
64transmission of nerve impulse (GO:0019226)3.11570959
65negative regulation of cytosolic calcium ion concentration (GO:0051481)3.06186980
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06062183
67startle response (GO:0001964)3.05484211
68regulation of collateral sprouting (GO:0048670)3.05400991
69regulation of vesicle fusion (GO:0031338)3.04728914
70neurotransmitter-gated ion channel clustering (GO:0072578)3.03540745
71negative regulation of astrocyte differentiation (GO:0048712)3.02789258
72response to auditory stimulus (GO:0010996)3.02323202
73cellular response to sterol (GO:0036315)3.02111215
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01206028
75innervation (GO:0060384)3.00806157
76long-term synaptic potentiation (GO:0060291)2.99840157
77central nervous system projection neuron axonogenesis (GO:0021952)2.98463959
78axonal fasciculation (GO:0007413)2.97407693
79C4-dicarboxylate transport (GO:0015740)2.94505968
80postsynaptic membrane organization (GO:0001941)2.93302127
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.93055132
82central nervous system neuron axonogenesis (GO:0021955)2.93045562
83chemosensory behavior (GO:0007635)2.92388828
84membrane depolarization during action potential (GO:0086010)2.91688556
85positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91535474
86regulation of neurotransmitter levels (GO:0001505)2.90474676
87detection of light stimulus involved in visual perception (GO:0050908)2.90334061
88detection of light stimulus involved in sensory perception (GO:0050962)2.90334061
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89718372
90DNA double-strand break processing (GO:0000729)2.89673583
91neural tube formation (GO:0001841)2.89184337
92regulation of neurotransmitter transport (GO:0051588)2.87687082
93response to histamine (GO:0034776)2.85610177
94positive regulation of oligodendrocyte differentiation (GO:0048714)2.84658034
95cell migration in hindbrain (GO:0021535)2.83943668
96membrane depolarization (GO:0051899)2.83740499
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83188889
98cellular response to cholesterol (GO:0071397)2.83070907
99spinal cord development (GO:0021510)2.82728349
100behavioral defense response (GO:0002209)2.82381695
101behavioral fear response (GO:0001662)2.82381695
102regulation of synaptic plasticity (GO:0048167)2.82280038
103regulation of synaptic transmission, glutamatergic (GO:0051966)2.82234275
104righting reflex (GO:0060013)2.81516140
105neuromuscular process controlling posture (GO:0050884)2.80933075
106potassium ion homeostasis (GO:0055075)2.79792813
107auditory behavior (GO:0031223)2.79642396
108presynaptic membrane assembly (GO:0097105)2.79313788
109neuronal ion channel clustering (GO:0045161)2.77969069
110regulation of synapse structural plasticity (GO:0051823)2.76961060
111protein localization to cilium (GO:0061512)2.76762078
112epithelial cilium movement (GO:0003351)2.76401260
113cilium morphogenesis (GO:0060271)2.75787277
114regulation of clathrin-mediated endocytosis (GO:2000369)2.74252469
115cell communication by electrical coupling (GO:0010644)2.74072505
116potassium ion import (GO:0010107)2.73304070
117synaptic transmission (GO:0007268)2.72623686
118appendage development (GO:0048736)2.72439955
119limb development (GO:0060173)2.72439955
120presynaptic membrane organization (GO:0097090)2.72225947
121synapse assembly (GO:0007416)2.72036352
122positive regulation of neurotransmitter transport (GO:0051590)2.71441149
123adult walking behavior (GO:0007628)2.70852355
124cerebellar granule cell differentiation (GO:0021707)2.70110284
125cilium organization (GO:0044782)2.68168261
126fucose catabolic process (GO:0019317)2.67882787
127L-fucose metabolic process (GO:0042354)2.67882787
128L-fucose catabolic process (GO:0042355)2.67882787
129regulation of ARF protein signal transduction (GO:0032012)2.67325427
130fear response (GO:0042596)2.66839372
131cilium assembly (GO:0042384)2.66784605
132cell proliferation in forebrain (GO:0021846)2.66727576
133learning (GO:0007612)2.66032430
134neuronal action potential (GO:0019228)2.65532173
135establishment of nucleus localization (GO:0040023)2.65031390
136intraciliary transport (GO:0042073)2.64870770
137positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.62752241
138mechanosensory behavior (GO:0007638)2.62681359
139axon ensheathment in central nervous system (GO:0032291)2.62427683
140central nervous system myelination (GO:0022010)2.62427683
141regulation of respiratory system process (GO:0044065)2.60597489
142olfactory bulb development (GO:0021772)2.59901865
143regulation of neurotransmitter uptake (GO:0051580)2.59628443
144axoneme assembly (GO:0035082)2.59056412
145photoreceptor cell development (GO:0042461)2.58739660
146negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58658764
147regulation of timing of cell differentiation (GO:0048505)2.57304738
148regulation of action potential (GO:0098900)2.56834864
149positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.55783398
150behavioral response to ethanol (GO:0048149)2.55662706
151negative regulation of axon guidance (GO:1902668)2.54808293
152inner ear receptor stereocilium organization (GO:0060122)2.54366012
153forebrain neuron differentiation (GO:0021879)2.51568900
154negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51540030
155regulation of development, heterochronic (GO:0040034)2.49561827
156cilium movement (GO:0003341)2.48081941
157cAMP catabolic process (GO:0006198)2.47092182
158platelet dense granule organization (GO:0060155)2.46765055
159negative regulation of axon extension involved in axon guidance (GO:0048843)2.44283611
160regulation of mesoderm development (GO:2000380)2.44143826
161retina layer formation (GO:0010842)2.44092449
162cerebral cortex cell migration (GO:0021795)2.43480149
163indolalkylamine metabolic process (GO:0006586)2.42192474
164tachykinin receptor signaling pathway (GO:0007217)2.42120352
165detection of mechanical stimulus involved in sensory perception (GO:0050974)2.41582411
166atrial cardiac muscle cell action potential (GO:0086014)2.40613926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.76654926
2GBX2_23144817_ChIP-Seq_PC3_Human3.65926114
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80925462
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.72504773
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66537620
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.64659916
7DROSHA_22980978_ChIP-Seq_HELA_Human2.53842832
8ZNF274_21170338_ChIP-Seq_K562_Hela2.51379016
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38762937
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38762937
11REST_21632747_ChIP-Seq_MESCs_Mouse2.36178921
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32810924
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32538556
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27682074
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.26581580
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18105076
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17634856
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16764945
19FUS_26573619_Chip-Seq_HEK293_Human2.13867712
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.12434978
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11979927
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08840947
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08540462
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.06771456
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.03683101
26AR_21572438_ChIP-Seq_LNCaP_Human2.03588128
27EWS_26573619_Chip-Seq_HEK293_Human2.00895689
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.00302960
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97313395
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88767807
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.85531554
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.83386822
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81012858
34* REST_18959480_ChIP-ChIP_MESCs_Mouse1.78461318
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73208583
36SMAD4_21799915_ChIP-Seq_A2780_Human1.72552706
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.71810305
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71419922
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.67899870
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66145954
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65070091
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58467599
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54821813
44BCAT_22108803_ChIP-Seq_LS180_Human1.51004179
45IGF1R_20145208_ChIP-Seq_DFB_Human1.48416498
46TAF15_26573619_Chip-Seq_HEK293_Human1.46828941
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45984100
48P300_19829295_ChIP-Seq_ESCs_Human1.45965785
49* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43724699
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42087940
51CBP_20019798_ChIP-Seq_JUKART_Human1.41475778
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41475778
53* STAT3_23295773_ChIP-Seq_U87_Human1.35951954
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.35338888
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35107247
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33664164
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32549954
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32087604
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31939221
60RNF2_27304074_Chip-Seq_NSC_Mouse1.29534603
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29278234
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28951415
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27523976
64AR_19668381_ChIP-Seq_PC3_Human1.27011544
65* SMAD3_21741376_ChIP-Seq_EPCs_Human1.26681406
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.26535921
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24272784
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23920599
69NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.23809597
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.23588341
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23412847
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22711472
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.21873051
74AR_25329375_ChIP-Seq_VCAP_Human1.21244140
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20185658
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20123282
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.20055785
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.19701669
79* TCF4_22108803_ChIP-Seq_LS180_Human1.19355525
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19319996
81FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19289253
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.19101654
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18920640
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18884368
85TCF4_23295773_ChIP-Seq_U87_Human1.17423722
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.17377777
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17297204
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17172697
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17123890
90VDR_22108803_ChIP-Seq_LS180_Human1.16449029
91IRF1_19129219_ChIP-ChIP_H3396_Human1.16275683
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.15223747
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13443593
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.13306404
95AHR_22903824_ChIP-Seq_MCF-7_Human1.13117474
96P53_22387025_ChIP-Seq_ESCs_Mouse1.12439272
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11903241
98* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11598112
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11178194
100* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10818771
101* PRDM14_20953172_ChIP-Seq_ESCs_Human1.10780411
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10715482
103* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10335566
104KDM2B_26808549_Chip-Seq_REH_Human1.09537841
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09190640
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09190640
107TP53_22573176_ChIP-Seq_HFKS_Human1.08799306
108* SMAD4_21741376_ChIP-Seq_HESCs_Human1.07960601
109NANOG_19829295_ChIP-Seq_ESCs_Human1.07438805
110SOX2_19829295_ChIP-Seq_ESCs_Human1.07438805
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07018042
112WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06667689
113* SMAD3_21741376_ChIP-Seq_HESCs_Human1.06591850
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.06301765
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06264010
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04755441
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03769122
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02754258
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.02461760
120MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01449947
121* RUNX2_22187159_ChIP-Seq_PCA_Human1.00726616
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00505142
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99453878
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98440880
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97986975
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96140198
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.94509750
128RXR_22108803_ChIP-Seq_LS180_Human0.93840483
129ER_23166858_ChIP-Seq_MCF-7_Human0.93505876
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.92197204
131* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91646396
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90645764
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.90270467
134* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89915607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.69851971
2MP0003880_abnormal_central_pattern4.06066387
3MP0003635_abnormal_synaptic_transmissio3.68439692
4MP0005423_abnormal_somatic_nervous3.57178442
5MP0009046_muscle_twitch3.22219217
6MP0004270_analgesia3.17447905
7MP0001968_abnormal_touch/_nociception3.10313002
8MP0009745_abnormal_behavioral_response3.07567502
9MP0002063_abnormal_learning/memory/cond2.91503150
10MP0002064_seizures2.89066599
11MP0001486_abnormal_startle_reflex2.63800209
12MP0005551_abnormal_eye_electrophysiolog2.60565439
13MP0002735_abnormal_chemical_nociception2.59302202
14MP0002572_abnormal_emotion/affect_behav2.56931999
15MP0002734_abnormal_mechanical_nocicepti2.51778515
16MP0002272_abnormal_nervous_system2.46702174
17MP0002736_abnormal_nociception_after2.40465685
18MP0002067_abnormal_sensory_capabilities2.25968382
19MP0001501_abnormal_sleep_pattern2.03957426
20MP0000778_abnormal_nervous_system2.02892378
21MP0008569_lethality_at_weaning1.97186665
22MP0005646_abnormal_pituitary_gland1.94125234
23MP0001440_abnormal_grooming_behavior1.93338968
24MP0002184_abnormal_innervation1.91319322
25MP0003136_yellow_coat_color1.90409971
26MP0003787_abnormal_imprinting1.89215294
27MP0001529_abnormal_vocalization1.88258775
28MP0004742_abnormal_vestibular_system1.86228409
29MP0001970_abnormal_pain_threshold1.84535967
30MP0002557_abnormal_social/conspecific_i1.83341338
31MP0008877_abnormal_DNA_methylation1.81988188
32MP0006276_abnormal_autonomic_nervous1.77348620
33MP0002733_abnormal_thermal_nociception1.75410164
34MP0005253_abnormal_eye_physiology1.73975532
35MP0004885_abnormal_endolymph1.72659055
36MP0006072_abnormal_retinal_apoptosis1.68931802
37MP0005645_abnormal_hypothalamus_physiol1.66957837
38MP0003879_abnormal_hair_cell1.59150647
39MP0002882_abnormal_neuron_morphology1.59035442
40MP0004858_abnormal_nervous_system1.57867594
41MP0004811_abnormal_neuron_physiology1.57686837
42MP0000569_abnormal_digit_pigmentation1.56639099
43MP0005386_behavior/neurological_phenoty1.55926535
44MP0004924_abnormal_behavior1.55926535
45MP0004142_abnormal_muscle_tone1.55346194
46MP0004043_abnormal_pH_regulation1.49966801
47MP0003119_abnormal_digestive_system1.44173141
48MP0009780_abnormal_chondrocyte_physiolo1.44121287
49MP0008789_abnormal_olfactory_epithelium1.43990618
50MP0000955_abnormal_spinal_cord1.42804182
51MP0001502_abnormal_circadian_rhythm1.40919020
52MP0005171_absent_coat_pigmentation1.38948749
53MP0002229_neurodegeneration1.38439531
54MP0002066_abnormal_motor_capabilities/c1.36135784
55MP0003890_abnormal_embryonic-extraembry1.35032191
56MP0003121_genomic_imprinting1.34577939
57MP0005187_abnormal_penis_morphology1.28471867
58MP0002234_abnormal_pharynx_morphology1.27910230
59MP0004133_heterotaxia1.27244337
60MP0002638_abnormal_pupillary_reflex1.25872956
61MP0008961_abnormal_basal_metabolism1.25840908
62MP0002751_abnormal_autonomic_nervous1.24580681
63MP0003122_maternal_imprinting1.23374562
64MP0001963_abnormal_hearing_physiology1.22959072
65MP0001984_abnormal_olfaction1.22519412
66MP0001188_hyperpigmentation1.21402768
67MP0003195_calcinosis1.20977164
68MP0002938_white_spotting1.19549544
69MP0000049_abnormal_middle_ear1.19027414
70MP0002752_abnormal_somatic_nervous1.17207725
71MP0003633_abnormal_nervous_system1.15980372
72MP0002822_catalepsy1.15199884
73MP0005409_darkened_coat_color1.14243156
74MP0002928_abnormal_bile_duct1.12427356
75MP0001986_abnormal_taste_sensitivity1.09679341
76MP0002152_abnormal_brain_morphology1.09262184
77MP0002102_abnormal_ear_morphology1.07994734
78MP0000427_abnormal_hair_cycle1.05036192
79MP0003937_abnormal_limbs/digits/tail_de1.04971010
80MP0002909_abnormal_adrenal_gland1.04637811
81MP0005367_renal/urinary_system_phenotyp1.00041210
82MP0000516_abnormal_urinary_system1.00041210
83MP0001905_abnormal_dopamine_level0.97396661
84MP0005174_abnormal_tail_pigmentation0.97025164
85MP0004147_increased_porphyrin_level0.96803979
86MP0001765_abnormal_ion_homeostasis0.96192399
87MP0005499_abnormal_olfactory_system0.95553257
88MP0005394_taste/olfaction_phenotype0.95553257
89MP0002069_abnormal_eating/drinking_beha0.94167442
90MP0000631_abnormal_neuroendocrine_gland0.93647117
91MP0003631_nervous_system_phenotype0.92113846
92MP0001485_abnormal_pinna_reflex0.91971870
93MP0000026_abnormal_inner_ear0.90863630
94MP0003938_abnormal_ear_development0.89994094
95MP0002837_dystrophic_cardiac_calcinosis0.88696342
96MP0003634_abnormal_glial_cell0.88679243
97MP0000372_irregular_coat_pigmentation0.88005188
98MP0003329_amyloid_beta_deposits0.87971357
99MP0006292_abnormal_olfactory_placode0.87775290
100MP0005377_hearing/vestibular/ear_phenot0.87537889
101MP0003878_abnormal_ear_physiology0.87537889
102MP0000647_abnormal_sebaceous_gland0.87243842
103MP0000383_abnormal_hair_follicle0.86465855
104MP0005195_abnormal_posterior_eye0.86241919
105MP0005248_abnormal_Harderian_gland0.84337494
106MP0010386_abnormal_urinary_bladder0.84313490
107MP0005084_abnormal_gallbladder_morpholo0.80903426
108MP0000920_abnormal_myelination0.79742068
109MP0002233_abnormal_nose_morphology0.79046499
110MP0005535_abnormal_body_temperature0.78090953
111MP0008872_abnormal_physiological_respon0.77322349
112MP0004145_abnormal_muscle_electrophysio0.76311781
113MP0002876_abnormal_thyroid_physiology0.72672889
114MP0003283_abnormal_digestive_organ0.70773909
115MP0001177_atelectasis0.68694850
116MP0003011_delayed_dark_adaptation0.67375882
117MP0008874_decreased_physiological_sensi0.63672156
118MP0003861_abnormal_nervous_system0.63080942
119MP0010769_abnormal_survival0.61387141
120MP0005391_vision/eye_phenotype0.61262991
121MP0004510_myositis0.60790642
122MP0005310_abnormal_salivary_gland0.60462839
123MP0002082_postnatal_lethality0.59570011
124MP0010770_preweaning_lethality0.59570011
125MP0010768_mortality/aging0.57877049
126MP0003045_fibrosis0.57291712
127MP0002090_abnormal_vision0.56372153
128MP0003632_abnormal_nervous_system0.56054740
129MP0003172_abnormal_lysosome_physiology0.54731205
130MP0002653_abnormal_ependyma_morphology0.54088913

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.62634134
2Febrile seizures (HP:0002373)4.47005735
3Myokymia (HP:0002411)4.38229038
4Congenital stationary night blindness (HP:0007642)4.34290110
5Progressive cerebellar ataxia (HP:0002073)4.26734516
6Focal seizures (HP:0007359)4.19438681
7Epileptic encephalopathy (HP:0200134)4.02902245
8True hermaphroditism (HP:0010459)3.82104892
9Pancreatic cysts (HP:0001737)3.74497261
10Pancreatic fibrosis (HP:0100732)3.70450567
11Increased circulating renin level (HP:0000848)3.59156053
12Bony spicule pigmentary retinopathy (HP:0007737)3.49817125
13Visual hallucinations (HP:0002367)3.48745017
14Atonic seizures (HP:0010819)3.43151026
15Metabolic alkalosis (HP:0200114)3.41828096
16Action tremor (HP:0002345)3.39119065
17Central scotoma (HP:0000603)3.37348293
18Abnormality of macular pigmentation (HP:0008002)3.34888446
19Dyschromatopsia (HP:0007641)3.30677525
20Molar tooth sign on MRI (HP:0002419)3.22971587
21Abnormality of midbrain morphology (HP:0002418)3.22971587
22Genetic anticipation (HP:0003743)3.20195866
23Gaze-evoked nystagmus (HP:0000640)3.18367442
24Broad-based gait (HP:0002136)3.15758107
25Medial flaring of the eyebrow (HP:0010747)3.13856866
26Absence seizures (HP:0002121)3.09113768
27Nephronophthisis (HP:0000090)3.05395609
28Abnormal ciliary motility (HP:0012262)3.00623302
29Abnormal eating behavior (HP:0100738)2.94572666
30Generalized tonic-clonic seizures (HP:0002069)2.81636081
31Hypomagnesemia (HP:0002917)2.77162424
32Congenital primary aphakia (HP:0007707)2.76875049
33Abnormal respiratory motile cilium physiology (HP:0012261)2.75167962
34Urinary bladder sphincter dysfunction (HP:0002839)2.74245407
35Hyperventilation (HP:0002883)2.72470083
36Genital tract atresia (HP:0001827)2.72312078
37Dialeptic seizures (HP:0011146)2.72238327
38Supranuclear gaze palsy (HP:0000605)2.71471057
39Abnormality of the renal medulla (HP:0100957)2.69565724
40Truncal ataxia (HP:0002078)2.68162865
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.67449257
42Dysdiadochokinesis (HP:0002075)2.67155298
43Intestinal atresia (HP:0011100)2.61372472
44Abolished electroretinogram (ERG) (HP:0000550)2.60487419
45Absent/shortened dynein arms (HP:0200106)2.57938014
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.57938014
47Impaired vibration sensation in the lower limbs (HP:0002166)2.57446436
48Vaginal atresia (HP:0000148)2.56860910
49Abnormal rod and cone electroretinograms (HP:0008323)2.54860600
50Scotoma (HP:0000575)2.49042696
51Hypokalemic alkalosis (HP:0001949)2.46894296
52Urinary urgency (HP:0000012)2.44188366
53Dysmetria (HP:0001310)2.41901119
54Abnormality of the renal cortex (HP:0011035)2.41841665
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.41774643
56Impaired smooth pursuit (HP:0007772)2.40181852
57Hemiplegia (HP:0002301)2.39300263
58Decreased central vision (HP:0007663)2.38644075
59Scanning speech (HP:0002168)2.37756077
60Polydipsia (HP:0001959)2.37461936
61Abnormal drinking behavior (HP:0030082)2.37461936
62Abnormality of renin-angiotensin system (HP:0000847)2.36799946
63Abnormality of binocular vision (HP:0011514)2.36700229
64Diplopia (HP:0000651)2.36700229
65Lissencephaly (HP:0001339)2.32740928
66Abnormality of the labia minora (HP:0012880)2.32426392
67Polyuria (HP:0000103)2.31787117
68Hyperactive renin-angiotensin system (HP:0000841)2.31132488
69Type II lissencephaly (HP:0007260)2.30676398
70Keratoconus (HP:0000563)2.30266263
71Increased corneal curvature (HP:0100692)2.30266263
72Abnormality of the corticospinal tract (HP:0002492)2.29642993
73Excessive salivation (HP:0003781)2.29263941
74Drooling (HP:0002307)2.29263941
75Short tibia (HP:0005736)2.28330200
76Depression (HP:0000716)2.28022143
77Volvulus (HP:0002580)2.27607689
78Postaxial foot polydactyly (HP:0001830)2.27159137
79Cystic liver disease (HP:0006706)2.25850891
80Chronic hepatic failure (HP:0100626)2.25418928
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.25199650
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24605436
83Ankle clonus (HP:0011448)2.24509081
84Optic nerve hypoplasia (HP:0000609)2.23679210
85Abnormal respiratory epithelium morphology (HP:0012253)2.22623126
86Abnormal respiratory motile cilium morphology (HP:0005938)2.22623126
87Postural instability (HP:0002172)2.20821764
88Fetal akinesia sequence (HP:0001989)2.20068606
89Pendular nystagmus (HP:0012043)2.18975634
90Postaxial hand polydactyly (HP:0001162)2.18927759
91Abnormality of magnesium homeostasis (HP:0004921)2.18079464
92Oligodactyly (hands) (HP:0001180)2.17817885
93Attenuation of retinal blood vessels (HP:0007843)2.16062360
94Poor eye contact (HP:0000817)2.15025620
95Megalencephaly (HP:0001355)2.14975849
96Abnormality of ocular smooth pursuit (HP:0000617)2.14559577
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.14360167
98Anencephaly (HP:0002323)2.12889094
99Tented upper lip vermilion (HP:0010804)2.11046404
100Renal cortical cysts (HP:0000803)2.10713321
101Sclerocornea (HP:0000647)2.10500764
102Pachygyria (HP:0001302)2.09460656
103Absent speech (HP:0001344)2.09121924
104Mutism (HP:0002300)2.07176989
105Septo-optic dysplasia (HP:0100842)2.06641480
106Hemiparesis (HP:0001269)2.06013056
107Abnormal urine output (HP:0012590)2.05262808
108Spastic gait (HP:0002064)2.05044481
109Specific learning disability (HP:0001328)2.04427670
110Agitation (HP:0000713)2.03733386
111Abnormality of chloride homeostasis (HP:0011422)2.03393226
112Impaired social interactions (HP:0000735)2.02482216
113Abnormal social behavior (HP:0012433)2.02482216
114Dysmetric saccades (HP:0000641)2.01919208
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00807145
116Polyphagia (HP:0002591)1.99562950
117Hyperaldosteronism (HP:0000859)1.99325476
118Poor coordination (HP:0002370)1.98161546
119Gait imbalance (HP:0002141)1.97232773
120Inability to walk (HP:0002540)1.96230935
121Choroideremia (HP:0001139)1.95048530
122Congenital hepatic fibrosis (HP:0002612)1.93391795
123Anxiety (HP:0000739)1.93128889
124Renal hypoplasia (HP:0000089)1.92860693
125Horizontal nystagmus (HP:0000666)1.92078213
126Papilledema (HP:0001085)1.91901497
127Chorioretinal atrophy (HP:0000533)1.91523384
128Amblyopia (HP:0000646)1.91086697
129Abnormality of renal excretion (HP:0011036)1.86900498
130Cutaneous finger syndactyly (HP:0010554)1.86751220
131Status epilepticus (HP:0002133)1.86635628
132Cerebellar dysplasia (HP:0007033)1.86563449
133Progressive inability to walk (HP:0002505)1.86246093
134Gastrointestinal atresia (HP:0002589)1.85701142
135Photophobia (HP:0000613)1.83649435
136Intention tremor (HP:0002080)1.82693528
137Preaxial hand polydactyly (HP:0001177)1.82689244
138Short foot (HP:0001773)1.82535495
139Small hand (HP:0200055)1.82380148
140Epileptiform EEG discharges (HP:0011182)1.82346490
141Narrow forehead (HP:0000341)1.81821077
142Stereotypic behavior (HP:0000733)1.81318796
143Type II diabetes mellitus (HP:0005978)1.79519368
144Stomach cancer (HP:0012126)1.78637586
145Male pseudohermaphroditism (HP:0000037)1.78277881
146Morphological abnormality of the middle ear (HP:0008609)1.75845952
147Methylmalonic acidemia (HP:0002912)1.75753761
148Furrowed tongue (HP:0000221)1.75167666
149Severe visual impairment (HP:0001141)1.74421377
150Limb dystonia (HP:0002451)1.74166989
151Abnormality of calcium-phosphate metabolism (HP:0100530)1.74155875
152EEG with generalized epileptiform discharges (HP:0011198)1.73726359
153Rhinitis (HP:0012384)1.72928477
154Protruding tongue (HP:0010808)1.72784302
155Nephrogenic diabetes insipidus (HP:0009806)1.72701523
156Short 4th metacarpal (HP:0010044)1.72637885
157Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.72637885
158Thyroiditis (HP:0100646)1.72206565
159Aplasia/Hypoplasia of the spleen (HP:0010451)1.72192976
160Asplenia (HP:0001746)1.71980387
161Impaired vibratory sensation (HP:0002495)1.71215611
162Aplasia/Hypoplasia of the sternum (HP:0006714)1.70973451
163Broad foot (HP:0001769)1.69268937
164Large for gestational age (HP:0001520)1.67974964
165Dyskinesia (HP:0100660)1.64991158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.41483255
2FRK4.19668706
3MARK13.52628305
4MAP3K92.92849185
5MAP2K72.65981725
6MAP3K42.60800518
7NTRK22.51452790
8MAP4K22.44437383
9BMPR1B2.38571047
10CASK2.32920799
11EPHA42.25962411
12MINK12.13191105
13WNK32.12312096
14TNIK2.09438363
15PAK62.04263207
16ADRBK22.00154496
17ZAK1.96558243
18MAP3K131.95226562
19OXSR11.90917956
20STK381.88595848
21ERBB31.79301880
22SIK21.78791138
23BCR1.74730772
24PNCK1.70520711
25ACVR1B1.69797257
26TRIM281.66613724
27NUAK11.60233432
28MAP3K121.59513358
29SGK4941.57447901
30SGK2231.57447901
31PRPF4B1.55276521
32SGK21.55246151
33WNK41.52579264
34MAPK131.52151732
35WNK11.50933084
36MAP2K41.42454832
37CAMKK11.41695318
38DYRK21.39075472
39SGK31.34798062
40TNK21.34417930
41CDK51.34408271
42KSR11.33981696
43DAPK21.33519108
44PRKCH1.32467514
45TAOK31.29430720
46RIPK41.28428466
47GRK11.25193244
48CSNK1G11.22069183
49PRKD31.21489632
50PRKCG1.21311428
51TXK1.19990048
52NTRK11.18968965
53TLK11.17605584
54EPHA31.16958658
55NEK61.14940018
56CSNK1G31.13929177
57FES1.12592950
58CSNK1A1L1.10304488
59SIK31.07439160
60UHMK11.01771831
61STK110.99840426
62GRK50.95864074
63SGK10.95041779
64KSR20.91738991
65VRK10.90460150
66DYRK1A0.87166509
67MARK20.86891864
68FGFR20.85279160
69INSRR0.82845411
70CAMKK20.81207494
71CAMK1G0.80826041
72PLK20.80712613
73TYRO30.80653377
74MAP3K70.78469189
75MAPK150.76449977
76CAMK2A0.75033027
77DAPK10.74892089
78CAMK10.74566892
79WEE10.73539384
80CDC42BPA0.73481943
81DYRK30.68187423
82PINK10.68090799
83ALK0.67791508
84BMPR20.67118945
85PHKG20.66692550
86PHKG10.66692550
87TIE10.65313020
88STK390.64845309
89PKN10.64341159
90CDK190.63685881
91NLK0.62421477
92CSNK1G20.61760337
93PDK10.57835122
94CAMK2B0.57716073
95PAK30.57419992
96EPHB20.56993580
97RET0.56169104
98MAPK70.55719385
99PRKCZ0.54910248
100CDK180.53923103
101PLK40.53458326
102FYN0.53079158
103PRKCQ0.52749827
104ITK0.52188492
105PRKD20.52186881
106CDK150.52044875
107MKNK10.51555124
108RPS6KA30.50949768
109IRAK20.50479338
110HIPK20.49755925
111CSNK1A10.49507055
112CCNB10.49133810
113YES10.47452489
114ERBB20.46875602
115PTK2B0.46297047
116CAMK40.46251768
117MAPK100.46152088
118FER0.45832854
119CSNK1D0.45368488
120CDK140.45085797
121PRKCE0.45045510
122PRKACA0.44969851
123RPS6KA50.44936448
124CDK30.44598446
125PRKCB0.44434869
126CDK11A0.42861823
127MAP3K20.42356985
128MAPK120.41155180
129ROCK10.39148636
130STK38L0.38683203
131OBSCN0.38646509
132AKT30.37569424
133PLK30.37072582
134STK240.36253773
135TGFBR10.33209231
136PDPK10.33021032
137ADRBK10.32418503
138PRKG10.32345185
139LMTK20.31261883
140MKNK20.31173537
141EIF2AK30.29519014
142BRD40.29134696
143CAMK2D0.26623270

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.65812268
2Nicotine addiction_Homo sapiens_hsa050333.53653019
3Synaptic vesicle cycle_Homo sapiens_hsa047212.91976966
4GABAergic synapse_Homo sapiens_hsa047272.45856872
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39745552
6Glutamatergic synapse_Homo sapiens_hsa047242.37573701
7Morphine addiction_Homo sapiens_hsa050322.35896863
8Circadian entrainment_Homo sapiens_hsa047132.29264385
9Olfactory transduction_Homo sapiens_hsa047402.22573095
10Long-term potentiation_Homo sapiens_hsa047202.12169044
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07150047
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96084587
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96057612
14Steroid biosynthesis_Homo sapiens_hsa001001.94678780
15Insulin secretion_Homo sapiens_hsa049111.92346369
16Salivary secretion_Homo sapiens_hsa049701.85153633
17Amphetamine addiction_Homo sapiens_hsa050311.84086451
18Dopaminergic synapse_Homo sapiens_hsa047281.82124875
19Nitrogen metabolism_Homo sapiens_hsa009101.79290702
20Taste transduction_Homo sapiens_hsa047421.78859856
21Gastric acid secretion_Homo sapiens_hsa049711.74982826
22Cholinergic synapse_Homo sapiens_hsa047251.73716047
23Protein export_Homo sapiens_hsa030601.70922032
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.61546362
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.57913559
26Serotonergic synapse_Homo sapiens_hsa047261.56464603
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.53839569
28Linoleic acid metabolism_Homo sapiens_hsa005911.51526631
29Long-term depression_Homo sapiens_hsa047301.49810844
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49379978
31Collecting duct acid secretion_Homo sapiens_hsa049661.48660282
32Fanconi anemia pathway_Homo sapiens_hsa034601.46302172
33Basal transcription factors_Homo sapiens_hsa030221.43100062
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.42326464
35Cocaine addiction_Homo sapiens_hsa050301.39688835
36Oxytocin signaling pathway_Homo sapiens_hsa049211.38946229
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.37157052
38Renin secretion_Homo sapiens_hsa049241.36446990
39Calcium signaling pathway_Homo sapiens_hsa040201.32798139
40Propanoate metabolism_Homo sapiens_hsa006401.30245344
41Type II diabetes mellitus_Homo sapiens_hsa049301.28330186
42cAMP signaling pathway_Homo sapiens_hsa040241.23690786
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18139731
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17008158
45Ether lipid metabolism_Homo sapiens_hsa005651.16927903
46Axon guidance_Homo sapiens_hsa043601.16381777
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14376366
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13714105
49ErbB signaling pathway_Homo sapiens_hsa040121.10663170
50GnRH signaling pathway_Homo sapiens_hsa049121.10623852
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.10277751
52* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08742275
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05906395
54Choline metabolism in cancer_Homo sapiens_hsa052311.04699275
55Basal cell carcinoma_Homo sapiens_hsa052171.02593626
56Gap junction_Homo sapiens_hsa045401.01982224
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01950628
58T cell receptor signaling pathway_Homo sapiens_hsa046601.01473551
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00286679
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99826537
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98724426
62Tryptophan metabolism_Homo sapiens_hsa003800.96768036
63Glioma_Homo sapiens_hsa052140.96740914
64Estrogen signaling pathway_Homo sapiens_hsa049150.94921136
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94594314
66Dorso-ventral axis formation_Homo sapiens_hsa043200.93310397
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.90204883
68* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89231527
69RNA degradation_Homo sapiens_hsa030180.88887882
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87099759
71Glycerolipid metabolism_Homo sapiens_hsa005610.86310836
72Inositol phosphate metabolism_Homo sapiens_hsa005620.84956812
73MAPK signaling pathway_Homo sapiens_hsa040100.84777713
74ABC transporters_Homo sapiens_hsa020100.84074995
75Oxidative phosphorylation_Homo sapiens_hsa001900.82430336
76Melanogenesis_Homo sapiens_hsa049160.81653921
77Regulation of autophagy_Homo sapiens_hsa041400.81468811
78Caffeine metabolism_Homo sapiens_hsa002320.80457861
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.79635063
80Type I diabetes mellitus_Homo sapiens_hsa049400.78775877
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.77529619
82Endometrial cancer_Homo sapiens_hsa052130.77263121
83Homologous recombination_Homo sapiens_hsa034400.75509104
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75422720
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74497797
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.74282487
87Peroxisome_Homo sapiens_hsa041460.74050963
88Pancreatic secretion_Homo sapiens_hsa049720.73814641
89* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73772724
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71746595
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71564983
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71532962
93Parkinsons disease_Homo sapiens_hsa050120.70814529
94Retinol metabolism_Homo sapiens_hsa008300.69933184
95Circadian rhythm_Homo sapiens_hsa047100.69434513
96Chemokine signaling pathway_Homo sapiens_hsa040620.67488009
97Ras signaling pathway_Homo sapiens_hsa040140.67381225
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66645325
99Thyroid hormone synthesis_Homo sapiens_hsa049180.66489299
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.62261538
101Selenocompound metabolism_Homo sapiens_hsa004500.62138377
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61612221
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59010946
104Fat digestion and absorption_Homo sapiens_hsa049750.58164242
105Colorectal cancer_Homo sapiens_hsa052100.58153582
106Hippo signaling pathway_Homo sapiens_hsa043900.57549745
107Wnt signaling pathway_Homo sapiens_hsa043100.57504366
108Rap1 signaling pathway_Homo sapiens_hsa040150.57282976
109Chemical carcinogenesis_Homo sapiens_hsa052040.56843787
110mTOR signaling pathway_Homo sapiens_hsa041500.56632525
111beta-Alanine metabolism_Homo sapiens_hsa004100.56274729
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55966943
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55844241
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.54585329
115Alzheimers disease_Homo sapiens_hsa050100.54424643
116RNA polymerase_Homo sapiens_hsa030200.54003876
117Vibrio cholerae infection_Homo sapiens_hsa051100.52240491
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52004431
119Prolactin signaling pathway_Homo sapiens_hsa049170.51398116
120Dilated cardiomyopathy_Homo sapiens_hsa054140.51191702
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50705461
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48127474
123Non-small cell lung cancer_Homo sapiens_hsa052230.47416618
124Huntingtons disease_Homo sapiens_hsa050160.46994519
125Mineral absorption_Homo sapiens_hsa049780.46377439
126Fatty acid metabolism_Homo sapiens_hsa012120.45666806
127VEGF signaling pathway_Homo sapiens_hsa043700.44874200
128Primary immunodeficiency_Homo sapiens_hsa053400.42958296
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42737172
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41738917
131Endocytosis_Homo sapiens_hsa041440.41711642
132Renal cell carcinoma_Homo sapiens_hsa052110.41515263
133Cardiac muscle contraction_Homo sapiens_hsa042600.40624055
134Systemic lupus erythematosus_Homo sapiens_hsa053220.39960995
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39366882
136Oocyte meiosis_Homo sapiens_hsa041140.39173140
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38966320
138Hedgehog signaling pathway_Homo sapiens_hsa043400.37802227
139Bile secretion_Homo sapiens_hsa049760.37110660
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35249792
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35142844
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34841559
143Ovarian steroidogenesis_Homo sapiens_hsa049130.34710461
144Rheumatoid arthritis_Homo sapiens_hsa053230.33519711
145Melanoma_Homo sapiens_hsa052180.32373509
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31385632
147Butanoate metabolism_Homo sapiens_hsa006500.31184722
148Alcoholism_Homo sapiens_hsa050340.30374685

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