ST8SIA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ST8SIA3 belongs to a family of sialyltransferases that form sialyl-alpha-2,8-sialyl-R linkages at the nonreducing termini of glycoconjugates (Lee et al., 1998 [PubMed 9826427]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59473262
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.42214418
3vocalization behavior (GO:0071625)5.35985850
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.10501198
5synaptic vesicle exocytosis (GO:0016079)5.09353370
6locomotory exploration behavior (GO:0035641)5.09108460
7neuron cell-cell adhesion (GO:0007158)4.97866218
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91667187
9synaptic vesicle maturation (GO:0016188)4.89906746
10regulation of glutamate receptor signaling pathway (GO:1900449)4.75540491
11protein localization to synapse (GO:0035418)4.72315656
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.68816928
13regulation of synaptic vesicle exocytosis (GO:2000300)4.67069286
14glutamate secretion (GO:0014047)4.46199846
15neuronal action potential propagation (GO:0019227)4.45489011
16neuron-neuron synaptic transmission (GO:0007270)4.30820215
17regulation of long-term neuronal synaptic plasticity (GO:0048169)4.29051650
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.27067751
19synaptic transmission, glutamatergic (GO:0035249)4.26451194
20glutamate receptor signaling pathway (GO:0007215)4.26178918
21exploration behavior (GO:0035640)4.21173729
22sodium ion export (GO:0071436)4.20892743
23neurotransmitter-gated ion channel clustering (GO:0072578)4.20087808
24synaptic vesicle docking involved in exocytosis (GO:0016081)4.19624413
25regulation of synapse structural plasticity (GO:0051823)4.18122677
26regulation of synaptic vesicle transport (GO:1902803)4.15178182
27neurotransmitter secretion (GO:0007269)4.13309514
28regulation of neuronal synaptic plasticity (GO:0048168)4.10060220
29transmission of nerve impulse (GO:0019226)3.93164680
30regulation of excitatory postsynaptic membrane potential (GO:0060079)3.90757978
31presynaptic membrane assembly (GO:0097105)3.89923986
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83974768
33positive regulation of membrane potential (GO:0045838)3.83531572
34dendritic spine morphogenesis (GO:0060997)3.80291848
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.78533322
36positive regulation of synaptic transmission, GABAergic (GO:0032230)3.73427984
37regulation of postsynaptic membrane potential (GO:0060078)3.71522498
38detection of calcium ion (GO:0005513)3.70995908
39potassium ion homeostasis (GO:0055075)3.70788394
40negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.68948205
41long-term memory (GO:0007616)3.68501062
42gamma-aminobutyric acid transport (GO:0015812)3.67476162
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.66068538
44positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.63396390
45neuron recognition (GO:0008038)3.61827912
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.61430426
47long-term synaptic potentiation (GO:0060291)3.61063902
48prepulse inhibition (GO:0060134)3.60976345
49regulation of synaptic transmission, glutamatergic (GO:0051966)3.60938149
50presynaptic membrane organization (GO:0097090)3.60234186
51synaptic transmission, dopaminergic (GO:0001963)3.58699578
52potassium ion import (GO:0010107)3.58246781
53cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.58105300
54striatum development (GO:0021756)3.54751552
55regulation of dendritic spine morphogenesis (GO:0061001)3.53570183
56response to histamine (GO:0034776)3.52220842
57behavioral response to cocaine (GO:0048148)3.50963235
58regulation of synaptic plasticity (GO:0048167)3.50660641
59L-amino acid import (GO:0043092)3.49090951
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.48878195
61negative regulation of dendrite morphogenesis (GO:0050774)3.48226476
62postsynaptic membrane organization (GO:0001941)3.47583282
63layer formation in cerebral cortex (GO:0021819)3.45337624
64auditory behavior (GO:0031223)3.41928442
65neurotransmitter transport (GO:0006836)3.40944889
66regulation of glutamate secretion (GO:0014048)3.40765717
67behavioral fear response (GO:0001662)3.39460759
68behavioral defense response (GO:0002209)3.39460759
69positive regulation of neurotransmitter transport (GO:0051590)3.38347008
70positive regulation of synapse maturation (GO:0090129)3.37534587
71serotonin metabolic process (GO:0042428)3.36563705
72central nervous system myelination (GO:0022010)3.27150075
73axon ensheathment in central nervous system (GO:0032291)3.27150075
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26988631
75neuronal ion channel clustering (GO:0045161)3.26252789
76regulation of vesicle fusion (GO:0031338)3.25981992
77membrane hyperpolarization (GO:0060081)3.25566783
78positive regulation of neurotransmitter secretion (GO:0001956)3.25503156
79regulation of neurotransmitter secretion (GO:0046928)3.24347040
80regulation of voltage-gated calcium channel activity (GO:1901385)3.24234333
81membrane depolarization (GO:0051899)3.22746291
82neuromuscular synaptic transmission (GO:0007274)3.22697033
83axonal fasciculation (GO:0007413)3.22561913
84learning (GO:0007612)3.22251983
85response to auditory stimulus (GO:0010996)3.22156818
86regulation of neurotransmitter levels (GO:0001505)3.22029881
87adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.20915399
88positive regulation of dendritic spine development (GO:0060999)3.18714305
89neuromuscular process controlling balance (GO:0050885)3.17618044
90dendritic spine organization (GO:0097061)3.17212917
91negative regulation of cytosolic calcium ion concentration (GO:0051481)3.16910820
92proline transport (GO:0015824)3.15725514
93innervation (GO:0060384)3.15055934
94fear response (GO:0042596)3.14017555
95startle response (GO:0001964)3.14009441
96regulation of female receptivity (GO:0045924)3.13380393
97synapse assembly (GO:0007416)3.12839278
98regulation of neurotransmitter transport (GO:0051588)3.12503238
99synaptic vesicle endocytosis (GO:0048488)3.11431837
100membrane depolarization during action potential (GO:0086010)3.09389838
101response to amphetamine (GO:0001975)3.09142534
102activation of protein kinase A activity (GO:0034199)3.08484413
103regulation of synaptic transmission, GABAergic (GO:0032228)3.08231796
104neuromuscular process controlling posture (GO:0050884)3.07228298
105positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06540695
106cellular sodium ion homeostasis (GO:0006883)3.05840563
107regulation of calcium ion-dependent exocytosis (GO:0017158)3.04523588
108cerebellar Purkinje cell differentiation (GO:0021702)3.04283430
109positive regulation of synaptic transmission (GO:0050806)3.04021639
110chemosensory behavior (GO:0007635)3.03090245
111cell communication by electrical coupling (GO:0010644)3.02410385
112cerebellar granule cell differentiation (GO:0021707)3.01413742
113adult walking behavior (GO:0007628)3.01209853
114cochlea development (GO:0090102)3.01035712
115signal release (GO:0023061)3.00856801
116mechanosensory behavior (GO:0007638)3.00240387
117mating behavior (GO:0007617)2.99870482
118synaptic transmission (GO:0007268)2.99340401
119positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.98648540
120regulation of dendritic spine development (GO:0060998)2.98237433
121female mating behavior (GO:0060180)2.97478298
122G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97173005
123cerebellar Purkinje cell layer development (GO:0021680)2.96946800
124primary amino compound metabolic process (GO:1901160)2.96531337
125cellular potassium ion homeostasis (GO:0030007)2.96504021
126amino acid import (GO:0043090)2.96278722
127regulation of synapse maturation (GO:0090128)2.96067677
128dopamine receptor signaling pathway (GO:0007212)2.95826808
129positive regulation of dendritic spine morphogenesis (GO:0061003)2.94309909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76699054
2GBX2_23144817_ChIP-Seq_PC3_Human4.10017613
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14319369
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05011404
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04033938
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.76054439
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.64372785
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60101651
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60101651
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58228255
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57370649
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.55145518
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45562121
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45547797
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43160329
16* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40957331
17DROSHA_22980978_ChIP-Seq_HELA_Human2.32818032
18TAF15_26573619_Chip-Seq_HEK293_Human2.27975692
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.23418054
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20879084
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.19054608
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.17994242
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07839196
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05516605
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04757334
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99142771
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94514504
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90853697
29AR_21572438_ChIP-Seq_LNCaP_Human1.90817980
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.90639555
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89661827
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78862593
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76459541
34SMAD4_21799915_ChIP-Seq_A2780_Human1.74563732
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70516751
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64824069
37P300_19829295_ChIP-Seq_ESCs_Human1.59152132
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.59124872
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57290775
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49836718
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47726338
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46285433
43ZNF274_21170338_ChIP-Seq_K562_Hela1.45899519
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.45033319
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44323241
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.43409472
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.38918680
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38094185
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36537828
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34648487
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33323203
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.32988563
53* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31775950
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.31772627
55STAT3_23295773_ChIP-Seq_U87_Human1.31035680
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30993366
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30158322
58AR_25329375_ChIP-Seq_VCAP_Human1.27774539
59RNF2_27304074_Chip-Seq_NSC_Mouse1.25727889
60FUS_26573619_Chip-Seq_HEK293_Human1.25353800
61* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22537284
62VDR_22108803_ChIP-Seq_LS180_Human1.21029998
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19986213
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18964082
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.18749633
66TCF4_23295773_ChIP-Seq_U87_Human1.16950641
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16572378
68AR_19668381_ChIP-Seq_PC3_Human1.14915204
69IGF1R_20145208_ChIP-Seq_DFB_Human1.10891537
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09093700
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08930172
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08474596
73RUNX2_22187159_ChIP-Seq_PCA_Human1.07156620
74ER_23166858_ChIP-Seq_MCF-7_Human1.06646275
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.04594400
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03821146
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03820581
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.03597866
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03440565
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03045655
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01740495
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01590436
83SMAD_19615063_ChIP-ChIP_OVARY_Human1.00890202
84AHR_22903824_ChIP-Seq_MCF-7_Human0.99143834
85* JUN_21703547_ChIP-Seq_K562_Human0.98780548
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98731203
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98553272
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97891440
89* RING1B_27294783_Chip-Seq_NPCs_Mouse0.97869650
90NANOG_18555785_Chip-Seq_ESCs_Mouse0.96580434
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96031957
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95184465
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.94544240
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.94363297
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93858639
96P53_22387025_ChIP-Seq_ESCs_Mouse0.93794515
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93721033
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93721033
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92755998
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92082640
101ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90542427
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88544262
103BCAT_22108803_ChIP-Seq_LS180_Human0.88150609
104CMYC_18555785_Chip-Seq_ESCs_Mouse0.88100838
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87954682
106FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87713508
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.87570909
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.87292453
109* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86671210
110SOX9_26525672_Chip-Seq_HEART_Mouse0.86632486
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85255987
112KDM2B_26808549_Chip-Seq_REH_Human0.84247924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.91330888
2MP0003880_abnormal_central_pattern5.11859770
3MP0003635_abnormal_synaptic_transmissio4.04021567
4MP0002822_catalepsy3.94115445
5MP0004270_analgesia3.73284574
6MP0009745_abnormal_behavioral_response3.53497808
7MP0002063_abnormal_learning/memory/cond3.32952569
8MP0002064_seizures3.17481599
9MP0009046_muscle_twitch3.13701547
10MP0001968_abnormal_touch/_nociception3.11387720
11MP0002572_abnormal_emotion/affect_behav2.89881999
12MP0002272_abnormal_nervous_system2.72918199
13MP0002734_abnormal_mechanical_nocicepti2.60783216
14MP0001486_abnormal_startle_reflex2.60740174
15MP0005423_abnormal_somatic_nervous2.58210216
16MP0002736_abnormal_nociception_after2.49381242
17MP0002735_abnormal_chemical_nociception2.36025818
18MP0001529_abnormal_vocalization2.32277629
19MP0001501_abnormal_sleep_pattern2.27587198
20MP0001440_abnormal_grooming_behavior2.17873524
21MP0002733_abnormal_thermal_nociception2.06620096
22MP0002067_abnormal_sensory_capabilities2.00589284
23MP0001970_abnormal_pain_threshold1.96740872
24MP0003123_paternal_imprinting1.95680416
25MP0006276_abnormal_autonomic_nervous1.93937394
26MP0005386_behavior/neurological_phenoty1.91836822
27MP0004924_abnormal_behavior1.91836822
28MP0000778_abnormal_nervous_system1.79594067
29MP0005646_abnormal_pituitary_gland1.77745467
30MP0002184_abnormal_innervation1.76386284
31MP0002557_abnormal_social/conspecific_i1.76350051
32MP0001984_abnormal_olfaction1.74836951
33MP0008877_abnormal_DNA_methylation1.74816486
34MP0002909_abnormal_adrenal_gland1.70435235
35MP0009780_abnormal_chondrocyte_physiolo1.68057288
36MP0008569_lethality_at_weaning1.65675326
37MP0001905_abnormal_dopamine_level1.65592446
38MP0004811_abnormal_neuron_physiology1.63981076
39MP0003329_amyloid_beta_deposits1.57876040
40MP0001188_hyperpigmentation1.53563762
41MP0003787_abnormal_imprinting1.52179212
42MP0005645_abnormal_hypothalamus_physiol1.48555952
43MP0000955_abnormal_spinal_cord1.47728265
44MP0003879_abnormal_hair_cell1.45876694
45MP0002066_abnormal_motor_capabilities/c1.43087309
46MP0003121_genomic_imprinting1.42749654
47MP0002882_abnormal_neuron_morphology1.39722561
48MP0004142_abnormal_muscle_tone1.38712504
49MP0003122_maternal_imprinting1.37559041
50MP0004858_abnormal_nervous_system1.30966455
51MP0004885_abnormal_endolymph1.28285540
52MP0001502_abnormal_circadian_rhythm1.22926084
53MP0003633_abnormal_nervous_system1.19443525
54MP0005409_darkened_coat_color1.15759400
55MP0002152_abnormal_brain_morphology1.06349494
56MP0004742_abnormal_vestibular_system1.06255047
57MP0003631_nervous_system_phenotype1.04975703
58MP0002229_neurodegeneration1.04191798
59MP0000013_abnormal_adipose_tissue1.00262820
60MP0008872_abnormal_physiological_respon1.00059548
61MP0010386_abnormal_urinary_bladder0.98979952
62MP0005551_abnormal_eye_electrophysiolog0.98632080
63MP0002069_abnormal_eating/drinking_beha0.97510049
64MP0000920_abnormal_myelination0.95896730
65MP0002837_dystrophic_cardiac_calcinosis0.95056640
66MP0000751_myopathy0.90548277
67MP0008874_decreased_physiological_sensi0.90367551
68MP0005535_abnormal_body_temperature0.88873113
69MP0004085_abnormal_heartbeat0.87818181
70MP0004147_increased_porphyrin_level0.86590160
71MP0004145_abnormal_muscle_electrophysio0.86409182
72MP0003634_abnormal_glial_cell0.86155953
73MP0001963_abnormal_hearing_physiology0.83778955
74MP0000631_abnormal_neuroendocrine_gland0.83427240
75MP0001177_atelectasis0.81898514
76MP0002876_abnormal_thyroid_physiology0.81415299
77MP0003690_abnormal_glial_cell0.81404772
78MP0002752_abnormal_somatic_nervous0.78149094
79MP0003632_abnormal_nervous_system0.77225616
80MP0005499_abnormal_olfactory_system0.77011316
81MP0005394_taste/olfaction_phenotype0.77011316
82MP0001485_abnormal_pinna_reflex0.76089168
83MP0001944_abnormal_pancreas_morphology0.74841651
84MP0001986_abnormal_taste_sensitivity0.73827151
85MP0001664_abnormal_digestion0.72974249
86MP0002090_abnormal_vision0.67781150
87MP0000639_abnormal_adrenal_gland0.66350822
88MP0005253_abnormal_eye_physiology0.65765936
89MP0002693_abnormal_pancreas_physiology0.65547346
90MP0002638_abnormal_pupillary_reflex0.64492826
91MP0000604_amyloidosis0.62396815
92MP0003195_calcinosis0.62378745
93MP0004133_heterotaxia0.60631066
94MP0004043_abnormal_pH_regulation0.60167032
95MP0003075_altered_response_to0.58574005
96MP0002102_abnormal_ear_morphology0.58508374
97MP0003137_abnormal_impulse_conducting0.58444173
98MP0000569_abnormal_digit_pigmentation0.57640163
99MP0005379_endocrine/exocrine_gland_phen0.57197172
100MP0005187_abnormal_penis_morphology0.57009234
101MP0005410_abnormal_fertilization0.56943705
102MP0005448_abnormal_energy_balance0.56878909
103MP0004215_abnormal_myocardial_fiber0.56619865
104MP0008961_abnormal_basal_metabolism0.56237917
105MP0002928_abnormal_bile_duct0.56036112
106MP0003183_abnormal_peptide_metabolism0.55596248
107MP0001943_abnormal_respiration0.55461563
108MP0001299_abnormal_eye_distance/0.55047541
109MP0002078_abnormal_glucose_homeostasis0.53555553
110MP0010768_mortality/aging0.52954529
111MP0003283_abnormal_digestive_organ0.52906148
112MP0006072_abnormal_retinal_apoptosis0.50588561
113MP0000026_abnormal_inner_ear0.50230852
114MP0003956_abnormal_body_size0.50088226
115MP0003861_abnormal_nervous_system0.49954907
116MP0010769_abnormal_survival0.49459220
117MP0002082_postnatal_lethality0.49405668
118MP0010770_preweaning_lethality0.49405668

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.01813589
2Myokymia (HP:0002411)6.89125325
3Focal seizures (HP:0007359)5.70388708
4Epileptic encephalopathy (HP:0200134)4.97604495
5Atonic seizures (HP:0010819)4.81020490
6Visual hallucinations (HP:0002367)4.60463887
7Febrile seizures (HP:0002373)4.31504623
8Absence seizures (HP:0002121)4.24310970
9Progressive cerebellar ataxia (HP:0002073)4.07133827
10Hyperventilation (HP:0002883)3.96991481
11Dialeptic seizures (HP:0011146)3.94129583
12Generalized tonic-clonic seizures (HP:0002069)3.74772386
13Broad-based gait (HP:0002136)3.74446994
14Action tremor (HP:0002345)3.55430687
15Gaze-evoked nystagmus (HP:0000640)3.41486514
16Impaired vibration sensation in the lower limbs (HP:0002166)3.27316067
17Supranuclear gaze palsy (HP:0000605)3.26030971
18Anxiety (HP:0000739)3.18031730
19Poor eye contact (HP:0000817)3.14021573
20Dysmetria (HP:0001310)3.09257206
21Dysdiadochokinesis (HP:0002075)3.08454364
22Ankle clonus (HP:0011448)3.08140910
23Truncal ataxia (HP:0002078)3.01799677
24Abnormal eating behavior (HP:0100738)2.99677695
25Depression (HP:0000716)2.98340066
26Amblyopia (HP:0000646)2.96871667
27Urinary bladder sphincter dysfunction (HP:0002839)2.96569703
28Abnormal social behavior (HP:0012433)2.85050434
29Impaired social interactions (HP:0000735)2.85050434
30Limb dystonia (HP:0002451)2.83951396
31Progressive inability to walk (HP:0002505)2.80264438
32Pheochromocytoma (HP:0002666)2.78774302
33Spastic gait (HP:0002064)2.77398128
34Scanning speech (HP:0002168)2.77206272
35Drooling (HP:0002307)2.71929156
36Excessive salivation (HP:0003781)2.71929156
37Torticollis (HP:0000473)2.71221435
38Epileptiform EEG discharges (HP:0011182)2.70088351
39Abnormality of the corticospinal tract (HP:0002492)2.64349746
40Neurofibrillary tangles (HP:0002185)2.63135247
41Postural instability (HP:0002172)2.58835144
42Fetal akinesia sequence (HP:0001989)2.54593208
43Sleep apnea (HP:0010535)2.52753594
44Focal dystonia (HP:0004373)2.52562451
45Mutism (HP:0002300)2.51572073
46Cerebral inclusion bodies (HP:0100314)2.51526444
47Termporal pattern (HP:0011008)2.51438080
48Insidious onset (HP:0003587)2.51438080
49EEG with generalized epileptiform discharges (HP:0011198)2.51261924
50Neuroendocrine neoplasm (HP:0100634)2.49361873
51Urinary urgency (HP:0000012)2.49183437
52Hyperinsulinemic hypoglycemia (HP:0000825)2.46478130
53Polyphagia (HP:0002591)2.43533397
54Impaired smooth pursuit (HP:0007772)2.42866781
55Stereotypic behavior (HP:0000733)2.38241923
56Absent speech (HP:0001344)2.37426152
57Hypsarrhythmia (HP:0002521)2.36643588
58Hemiparesis (HP:0001269)2.35827340
59Intention tremor (HP:0002080)2.33474159
60Bradykinesia (HP:0002067)2.32051885
61Craniofacial dystonia (HP:0012179)2.31745330
62Hemiplegia (HP:0002301)2.30076495
63Inability to walk (HP:0002540)2.29152022
64Genetic anticipation (HP:0003743)2.28266167
65Akinesia (HP:0002304)2.27172947
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.26968062
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26968062
68Increased circulating renin level (HP:0000848)2.26360038
69Cerebral hypomyelination (HP:0006808)2.22312229
70Impaired vibratory sensation (HP:0002495)2.21027542
71Diplopia (HP:0000651)2.20440637
72Abnormality of binocular vision (HP:0011514)2.20440637
73Gait imbalance (HP:0002141)2.19597401
74Papilledema (HP:0001085)2.18312971
75Hypothermia (HP:0002045)2.17452470
76Resting tremor (HP:0002322)2.15282715
77Muscular hypotonia of the trunk (HP:0008936)2.15000732
78Hypoglycemic seizures (HP:0002173)2.14541800
79Generalized myoclonic seizures (HP:0002123)2.14183527
80Dysmetric saccades (HP:0000641)2.13422091
81Lower limb muscle weakness (HP:0007340)2.11826932
82Abnormality of ocular smooth pursuit (HP:0000617)2.11593017
83Absent/shortened dynein arms (HP:0200106)2.10427420
84Dynein arm defect of respiratory motile cilia (HP:0012255)2.10427420
85Blue irides (HP:0000635)2.08239384
86Tetraplegia (HP:0002445)2.07586489
87Protruding tongue (HP:0010808)2.02140050
88Obstructive sleep apnea (HP:0002870)2.01295095
89Morphological abnormality of the pyramidal tract (HP:0002062)2.00419196
90Spastic tetraplegia (HP:0002510)1.99214137
91Incomplete penetrance (HP:0003829)1.98707277
92Status epilepticus (HP:0002133)1.97303977
93Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95817927
94Abnormality of the lower motor neuron (HP:0002366)1.93219234
95Failure to thrive in infancy (HP:0001531)1.93126639
96Specific learning disability (HP:0001328)1.92223175
97Gait ataxia (HP:0002066)1.91707730
98Megalencephaly (HP:0001355)1.88845815
99Abnormal hair whorl (HP:0010721)1.87755867
100Psychosis (HP:0000709)1.87496040
101Annular pancreas (HP:0001734)1.85357310
102Poor suck (HP:0002033)1.85115600
103Delusions (HP:0000746)1.84879377
104Postural tremor (HP:0002174)1.83881053
105Congenital primary aphakia (HP:0007707)1.83595451
106Abnormality of salivation (HP:0100755)1.83168852
107Sensory axonal neuropathy (HP:0003390)1.83103821
108Medial flaring of the eyebrow (HP:0010747)1.82464113
109Abnormality of the labia minora (HP:0012880)1.81983134
110Abnormality of saccadic eye movements (HP:0000570)1.79560357
111Ventricular fibrillation (HP:0001663)1.78544195
112Neuronal loss in central nervous system (HP:0002529)1.78158390
113Insulin-resistant diabetes mellitus (HP:0000831)1.77882791
114Prolonged QT interval (HP:0001657)1.77239876
115Clonus (HP:0002169)1.76951039
116Agitation (HP:0000713)1.76683340
117Ketoacidosis (HP:0001993)1.76286479
118Spastic tetraparesis (HP:0001285)1.74844232
119Restlessness (HP:0000711)1.74836098
120Diminished movement (HP:0002374)1.73993733
121Neoplasm of the peripheral nervous system (HP:0100007)1.73454212
122Hyperthyroidism (HP:0000836)1.73266116
123Peripheral hypomyelination (HP:0007182)1.72765479
124Hypoglycemic coma (HP:0001325)1.71519566
125Abnormal EKG (HP:0003115)1.70459207
126Choreoathetosis (HP:0001266)1.70443423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.95248390
2NTRK34.45453096
3MAP3K93.44478284
4MAP3K42.90254437
5CASK2.83643103
6MARK12.75186642
7MAP2K72.54457395
8MINK12.48797129
9MAP3K122.26698909
10FRK2.22075469
11TNIK2.20933756
12RIPK42.15629802
13DAPK22.11590152
14NTRK21.92155685
15PAK61.92141628
16KSR21.88684956
17CDK191.84656958
18MAP2K41.77796640
19PRPF4B1.66475794
20NTRK11.65659503
21ARAF1.64855073
22KSR11.64505742
23DAPK11.54733428
24CDK51.53692483
25PNCK1.50615206
26CAMKK11.44691045
27PLK21.44181336
28PRKD31.42910785
29OXSR11.39776047
30MAPK131.33933550
31FES1.26370255
32CAMKK21.25442515
33GRK51.24797070
34PRKCG1.22988174
35UHMK11.21415931
36CAMK2A1.12360487
37CAMK2B1.07810041
38MAP3K131.06364026
39SIK21.04669240
40MAP3K21.03970763
41MAP4K21.03299492
42BMPR21.02504478
43SGK2231.01758814
44SGK4941.01758814
45CDK180.98984107
46BCR0.98048670
47CDK140.96703916
48CDK150.93812769
49MAP2K60.92051532
50TYRO30.90538906
51STK390.88669737
52SGK20.84065390
53PTK2B0.82860475
54AKT30.82658926
55CDK11A0.82186368
56SIK30.79945530
57WNK30.79534235
58STK380.79303533
59RAF10.78963234
60STK110.76391007
61NEK60.76293393
62CSNK1G20.74059286
63PHKG20.72071199
64PHKG10.72071199
65SGK10.71587869
66PAK30.71263539
67CAMK10.67405157
68MARK20.65669346
69DYRK20.65206770
70WNK40.64634706
71CSNK1G10.64265035
72RET0.64130955
73TAOK10.63903801
74ALK0.63760907
75WNK10.63702525
76NME10.63657940
77CAMK40.62804044
78CAMK2D0.62212645
79PRKCH0.61958069
80BRAF0.60993427
81DYRK1A0.60792745
82PINK10.59527674
83PRKCE0.59457813
84SGK30.58285155
85FGR0.55834534
86PDPK10.55436543
87CSNK1A1L0.55223354
88TNK20.52959896
89CAMK2G0.52460633
90PDK10.52231273
91MAP3K10.50533609
92PRKG10.47580039
93FGFR20.46281196
94FYN0.45676287
95PRKCZ0.45646273
96INSRR0.45382664
97LIMK10.45243529
98RPS6KA30.44291523
99CSNK1E0.43994064
100CAMK1G0.43112551
101MAP2K10.42023080
102TRIM280.41718702
103CCNB10.41350203
104MAPK120.40349536
105CSNK1A10.40285323
106LATS20.40101678
107PRKCA0.39520149
108MAPK100.39265482
109ADRBK20.38736724
110ROCK20.38202830
111CSNK1D0.37475697
112GRK10.37249571
113GRK70.36706893
114FER0.35700810
115PRKACA0.34999307
116PKN10.34137879
117PRKAA10.33361158
118RIPK10.32963331
119PRKCB0.32738984
120ADRBK10.32670059
121CSNK1G30.31420388

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.99029787
2Synaptic vesicle cycle_Homo sapiens_hsa047213.36802228
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84852912
4GABAergic synapse_Homo sapiens_hsa047272.83720559
5Olfactory transduction_Homo sapiens_hsa047402.80770335
6Circadian entrainment_Homo sapiens_hsa047132.76488912
7Morphine addiction_Homo sapiens_hsa050322.75401082
8Long-term potentiation_Homo sapiens_hsa047202.71517454
9Amphetamine addiction_Homo sapiens_hsa050312.67409008
10Glutamatergic synapse_Homo sapiens_hsa047242.63437427
11Dopaminergic synapse_Homo sapiens_hsa047282.37230483
12Salivary secretion_Homo sapiens_hsa049702.11573807
13Cocaine addiction_Homo sapiens_hsa050302.01260429
14Collecting duct acid secretion_Homo sapiens_hsa049662.00010068
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95828994
16Insulin secretion_Homo sapiens_hsa049111.95679334
17Cholinergic synapse_Homo sapiens_hsa047251.95474976
18Serotonergic synapse_Homo sapiens_hsa047261.94709460
19Taste transduction_Homo sapiens_hsa047421.90593100
20Renin secretion_Homo sapiens_hsa049241.84685749
21Long-term depression_Homo sapiens_hsa047301.81655967
22Gastric acid secretion_Homo sapiens_hsa049711.72416184
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68762130
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.66962188
25Calcium signaling pathway_Homo sapiens_hsa040201.65505917
26Oxytocin signaling pathway_Homo sapiens_hsa049211.61281647
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53665522
28Gap junction_Homo sapiens_hsa045401.37503924
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37167988
30Vibrio cholerae infection_Homo sapiens_hsa051101.32463092
31GnRH signaling pathway_Homo sapiens_hsa049121.31827286
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30194059
33Vitamin B6 metabolism_Homo sapiens_hsa007501.28847090
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26038788
35cAMP signaling pathway_Homo sapiens_hsa040241.23883015
36Axon guidance_Homo sapiens_hsa043601.22298859
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17264991
38Cardiac muscle contraction_Homo sapiens_hsa042601.14856868
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09824276
40Phototransduction_Homo sapiens_hsa047441.03658783
41Type II diabetes mellitus_Homo sapiens_hsa049301.02510555
42Estrogen signaling pathway_Homo sapiens_hsa049151.01451059
43ErbB signaling pathway_Homo sapiens_hsa040120.98971839
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.96739622
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96566768
46Oxidative phosphorylation_Homo sapiens_hsa001900.96274292
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94363188
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93387677
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92744448
50Melanogenesis_Homo sapiens_hsa049160.92318357
51Glioma_Homo sapiens_hsa052140.91658802
52Alzheimers disease_Homo sapiens_hsa050100.89554919
53Oocyte meiosis_Homo sapiens_hsa041140.82520153
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81786372
55Pancreatic secretion_Homo sapiens_hsa049720.81690959
56Parkinsons disease_Homo sapiens_hsa050120.77671286
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.73470941
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69093739
59Regulation of autophagy_Homo sapiens_hsa041400.68900607
60Thyroid hormone synthesis_Homo sapiens_hsa049180.68232970
61Alcoholism_Homo sapiens_hsa050340.68147990
62Dorso-ventral axis formation_Homo sapiens_hsa043200.68118247
63MAPK signaling pathway_Homo sapiens_hsa040100.66612519
64Choline metabolism in cancer_Homo sapiens_hsa052310.63323547
65Type I diabetes mellitus_Homo sapiens_hsa049400.62486730
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59968315
67Ras signaling pathway_Homo sapiens_hsa040140.59834575
68Dilated cardiomyopathy_Homo sapiens_hsa054140.59788021
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57709329
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51010348
71Glucagon signaling pathway_Homo sapiens_hsa049220.50387135
72Rap1 signaling pathway_Homo sapiens_hsa040150.47957489
73VEGF signaling pathway_Homo sapiens_hsa043700.47047089
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44923834
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.44860910
76Mineral absorption_Homo sapiens_hsa049780.44630738
77Huntingtons disease_Homo sapiens_hsa050160.44462745
78Inositol phosphate metabolism_Homo sapiens_hsa005620.43955784
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.43624886
80Circadian rhythm_Homo sapiens_hsa047100.42555294
81Rheumatoid arthritis_Homo sapiens_hsa053230.41557467
82Endocytosis_Homo sapiens_hsa041440.41403107
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40416375
84Renal cell carcinoma_Homo sapiens_hsa052110.39961339
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39876593
86Ether lipid metabolism_Homo sapiens_hsa005650.37831687
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37178873
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35187222
89Prion diseases_Homo sapiens_hsa050200.34889526
90African trypanosomiasis_Homo sapiens_hsa051430.34795476
91beta-Alanine metabolism_Homo sapiens_hsa004100.34405809
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33758288
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33567792
94Ovarian steroidogenesis_Homo sapiens_hsa049130.33268268
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33166959
96Wnt signaling pathway_Homo sapiens_hsa043100.32663366
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32046812
98Non-small cell lung cancer_Homo sapiens_hsa052230.31791073
99Protein export_Homo sapiens_hsa030600.30938154
100Nitrogen metabolism_Homo sapiens_hsa009100.29277791
101Butanoate metabolism_Homo sapiens_hsa006500.28488407
102mTOR signaling pathway_Homo sapiens_hsa041500.27771054
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.27030591
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26765342
105Bile secretion_Homo sapiens_hsa049760.26372871
106Insulin signaling pathway_Homo sapiens_hsa049100.26258234
107Chemokine signaling pathway_Homo sapiens_hsa040620.26026603
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25845916
109Folate biosynthesis_Homo sapiens_hsa007900.25206175
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24096963
111Histidine metabolism_Homo sapiens_hsa003400.21770720
112Arginine biosynthesis_Homo sapiens_hsa002200.20906103
113Tight junction_Homo sapiens_hsa045300.20689319
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19137585
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16882046
116AMPK signaling pathway_Homo sapiens_hsa041520.15758114

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