ST8SIA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82261266
2neuronal action potential propagation (GO:0019227)5.78308351
3locomotory exploration behavior (GO:0035641)5.61125765
4synaptic vesicle exocytosis (GO:0016079)5.59304363
5vocalization behavior (GO:0071625)5.34351310
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.33281028
7synaptic vesicle maturation (GO:0016188)5.28119390
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15365013
9regulation of synaptic vesicle exocytosis (GO:2000300)5.03294802
10glutamate secretion (GO:0014047)5.00918783
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.86131437
12cellular potassium ion homeostasis (GO:0030007)4.82189480
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.79152117
14glutamate receptor signaling pathway (GO:0007215)4.75737273
15cerebellar granule cell differentiation (GO:0021707)4.63264191
16neurotransmitter secretion (GO:0007269)4.56957308
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.53206673
18G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.51124871
19sodium ion export (GO:0071436)4.49595084
20synaptic transmission, glutamatergic (GO:0035249)4.49337595
21regulation of synaptic vesicle transport (GO:1902803)4.48297061
22regulation of glutamate receptor signaling pathway (GO:1900449)4.31291169
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.30664558
24positive regulation of synapse maturation (GO:0090129)4.30351387
25protein localization to synapse (GO:0035418)4.27765676
26exploration behavior (GO:0035640)4.23561724
27neuron-neuron synaptic transmission (GO:0007270)4.21766297
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.19556763
29gamma-aminobutyric acid transport (GO:0015812)4.15664575
30cerebellar Purkinje cell differentiation (GO:0021702)4.13910777
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.13847280
32response to pheromone (GO:0019236)4.07848419
33neuron cell-cell adhesion (GO:0007158)3.97718873
34long-term memory (GO:0007616)3.96384804
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94874094
36neurotransmitter-gated ion channel clustering (GO:0072578)3.90760576
37regulation of neuronal synaptic plasticity (GO:0048168)3.87704478
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80283253
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.75810863
40cell communication by electrical coupling (GO:0010644)3.75465083
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.73082009
42synaptic vesicle endocytosis (GO:0048488)3.73008061
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.71236607
44long-term synaptic potentiation (GO:0060291)3.69981908
45neurotransmitter transport (GO:0006836)3.67599713
46L-amino acid import (GO:0043092)3.65868689
47positive regulation of membrane potential (GO:0045838)3.58280080
48regulation of postsynaptic membrane potential (GO:0060078)3.54444285
49serotonin metabolic process (GO:0042428)3.54067720
50layer formation in cerebral cortex (GO:0021819)3.51390997
51cell differentiation in hindbrain (GO:0021533)3.48038847
52regulation of synapse structural plasticity (GO:0051823)3.47207824
53regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.43694463
54membrane depolarization during action potential (GO:0086010)3.43518858
55regulation of neurotransmitter secretion (GO:0046928)3.40418969
56regulation of synaptic plasticity (GO:0048167)3.39686062
57positive regulation of dendritic spine development (GO:0060999)3.39287569
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39200826
59transmission of nerve impulse (GO:0019226)3.37985044
60axon ensheathment in central nervous system (GO:0032291)3.36961085
61central nervous system myelination (GO:0022010)3.36961085
62regulation of synapse maturation (GO:0090128)3.36118252
63detection of calcium ion (GO:0005513)3.34855292
64long term synaptic depression (GO:0060292)3.34514455
65regulation of neurotransmitter levels (GO:0001505)3.34508095
66neuromuscular process controlling posture (GO:0050884)3.34298993
67regulation of vesicle fusion (GO:0031338)3.34078420
68dendritic spine morphogenesis (GO:0060997)3.32453728
69activation of protein kinase A activity (GO:0034199)3.31253301
70regulation of dendritic spine development (GO:0060998)3.29551989
71amino acid import (GO:0043090)3.28954500
72postsynaptic membrane organization (GO:0001941)3.27469384
73neuronal ion channel clustering (GO:0045161)3.26821544
74potassium ion import (GO:0010107)3.26059356
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.25748771
76primary amino compound metabolic process (GO:1901160)3.24290099
77proline transport (GO:0015824)3.23611101
78presynaptic membrane assembly (GO:0097105)3.23116727
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.22345178
80membrane depolarization (GO:0051899)3.19152879
81startle response (GO:0001964)3.18248835
82cellular sodium ion homeostasis (GO:0006883)3.17060115
83innervation (GO:0060384)3.16843736
84C4-dicarboxylate transport (GO:0015740)3.15356684
85presynaptic membrane organization (GO:0097090)3.14480337
86neuron recognition (GO:0008038)3.12236761
87potassium ion homeostasis (GO:0055075)3.11493128
88chemosensory behavior (GO:0007635)3.08912197
89regulation of neurotransmitter transport (GO:0051588)3.08543568
90regulation of voltage-gated calcium channel activity (GO:1901385)3.07388890
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.06634993
92synapse assembly (GO:0007416)3.02833309
93fear response (GO:0042596)3.00672003
94synaptic transmission (GO:0007268)2.99987154
95positive regulation of neurotransmitter secretion (GO:0001956)2.99385780
96regulation of dendritic spine morphogenesis (GO:0061001)2.99198325
97membrane hyperpolarization (GO:0060081)2.99023097
98neurotransmitter uptake (GO:0001504)2.97627183
99neuromuscular process controlling balance (GO:0050885)2.96085959
100potassium ion transmembrane transport (GO:0071805)2.95323284
101cellular potassium ion transport (GO:0071804)2.95323284
102auditory behavior (GO:0031223)2.93517276
103behavioral defense response (GO:0002209)2.93267310
104behavioral fear response (GO:0001662)2.93267310
105establishment of synaptic vesicle localization (GO:0097480)2.92918321
106synaptic vesicle transport (GO:0048489)2.92918321
107negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.90342134
108negative regulation of dendrite morphogenesis (GO:0050774)2.90221638
109acidic amino acid transport (GO:0015800)2.89491082
110negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89106305
111positive regulation of neurotransmitter transport (GO:0051590)2.88991442
112learning (GO:0007612)2.88408506
113regulation of synaptic transmission (GO:0050804)2.88384813
114positive regulation of potassium ion transmembrane transport (GO:1901381)2.88297320
115pyrimidine nucleobase catabolic process (GO:0006208)2.87218493
116regulation of calcium ion-dependent exocytosis (GO:0017158)2.86205370
117glycine transport (GO:0015816)2.86067607
118neuromuscular synaptic transmission (GO:0007274)2.85845551
119adult walking behavior (GO:0007628)2.85497500
120synapse organization (GO:0050808)2.84976283
121axonal fasciculation (GO:0007413)2.83980773
122regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.82236548
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81534022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.14979913
2GBX2_23144817_ChIP-Seq_PC3_Human3.60417021
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17763119
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10859864
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01016587
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.94739958
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69347275
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69347275
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59133825
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56977431
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56132391
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54064241
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50610758
14RARB_27405468_Chip-Seq_BRAIN_Mouse2.49711796
15* DROSHA_22980978_ChIP-Seq_HELA_Human2.48508226
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47235697
17* REST_18959480_ChIP-ChIP_MESCs_Mouse2.36637026
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.35733359
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.31638549
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21430388
21* EED_16625203_ChIP-ChIP_MESCs_Mouse2.20456831
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.16645547
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16587587
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96560230
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78764348
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78609808
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78603487
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76330099
29SMAD4_21799915_ChIP-Seq_A2780_Human1.75162507
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72852047
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71316120
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70211221
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69865631
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68717705
35AR_21572438_ChIP-Seq_LNCaP_Human1.61437819
36TAF15_26573619_Chip-Seq_HEK293_Human1.56769048
37ZNF274_21170338_ChIP-Seq_K562_Hela1.56338521
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.46386783
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46258620
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41140805
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36369505
42SOX2_21211035_ChIP-Seq_LN229_Gbm1.33447697
43P300_19829295_ChIP-Seq_ESCs_Human1.31426147
44RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30724895
45AR_25329375_ChIP-Seq_VCAP_Human1.30694198
46AR_19668381_ChIP-Seq_PC3_Human1.29409762
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.28530992
48STAT3_23295773_ChIP-Seq_U87_Human1.26264752
49* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25172777
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23071391
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22112507
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.19724669
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.19667465
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19374954
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19212740
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.18730885
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18717399
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18157381
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17220504
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.16055196
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15743579
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15069544
63IGF1R_20145208_ChIP-Seq_DFB_Human1.15041860
64* TCF4_23295773_ChIP-Seq_U87_Human1.14014237
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13348408
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13012166
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11819364
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11483931
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.10044837
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09823948
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08964421
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07457796
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07350078
74TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07183660
75ER_23166858_ChIP-Seq_MCF-7_Human1.07016787
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.06858062
77WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05702688
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04895076
79CBP_20019798_ChIP-Seq_JUKART_Human1.04639261
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04639261
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03632409
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.02922720
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02442945
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.00887384
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00609239
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99534689
87SMAD3_21741376_ChIP-Seq_ESCs_Human0.99273404
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99191972
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99099281
90RING1B_27294783_Chip-Seq_NPCs_Mouse0.97502010
91P53_22387025_ChIP-Seq_ESCs_Mouse0.97262316
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96119888
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95658324
94KDM2B_26808549_Chip-Seq_REH_Human0.95631145
95* RUNX2_22187159_ChIP-Seq_PCA_Human0.95316345
96* SMAD4_21741376_ChIP-Seq_EPCs_Human0.95219261
97* TCF4_22108803_ChIP-Seq_LS180_Human0.94477323
98RNF2_27304074_Chip-Seq_NSC_Mouse0.93704083
99FUS_26573619_Chip-Seq_HEK293_Human0.93258719
100VDR_22108803_ChIP-Seq_LS180_Human0.93071033
101EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92742556
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92617348
103SUZ12_27294783_Chip-Seq_NPCs_Mouse0.92430909
104KDM2B_26808549_Chip-Seq_K562_Human0.92377922
105AHR_22903824_ChIP-Seq_MCF-7_Human0.91678305
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91043422
107* SMAD4_21741376_ChIP-Seq_HESCs_Human0.89397349
108WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89204833
109BCAT_22108803_ChIP-Seq_LS180_Human0.88909911
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88714071
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88714071
112NANOG_18555785_Chip-Seq_ESCs_Mouse0.88675935
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.88668065
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87740988
115TP53_16413492_ChIP-PET_HCT116_Human0.86878544
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86242096
117SMAD3_21741376_ChIP-Seq_HESCs_Human0.85942367
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.85221052
119TET1_21490601_ChIP-Seq_MESCs_Mouse0.84897887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.04963240
2MP0003880_abnormal_central_pattern4.13345305
3MP0003635_abnormal_synaptic_transmissio4.07890145
4MP0009046_muscle_twitch3.64114081
5MP0004270_analgesia3.53858539
6MP0009745_abnormal_behavioral_response3.29039747
7MP0002064_seizures3.18539139
8MP0002063_abnormal_learning/memory/cond3.15621089
9MP0002272_abnormal_nervous_system2.83894751
10MP0001968_abnormal_touch/_nociception2.75639346
11MP0002572_abnormal_emotion/affect_behav2.73525664
12MP0002734_abnormal_mechanical_nocicepti2.63258675
13MP0009780_abnormal_chondrocyte_physiolo2.51307829
14MP0008569_lethality_at_weaning2.48070244
15MP0001486_abnormal_startle_reflex2.44436239
16MP0002736_abnormal_nociception_after2.33556092
17MP0001501_abnormal_sleep_pattern2.33070231
18MP0004145_abnormal_muscle_electrophysio2.30823324
19MP0001440_abnormal_grooming_behavior2.25008632
20MP0002067_abnormal_sensory_capabilities2.19898176
21MP0005423_abnormal_somatic_nervous2.16600761
22MP0003329_amyloid_beta_deposits2.09667965
23MP0002909_abnormal_adrenal_gland1.99010768
24MP0002735_abnormal_chemical_nociception1.98110867
25MP0002837_dystrophic_cardiac_calcinosis1.89971162
26MP0002184_abnormal_innervation1.86797136
27MP0001970_abnormal_pain_threshold1.82058055
28MP0002733_abnormal_thermal_nociception1.80581517
29MP0003879_abnormal_hair_cell1.74016198
30MP0002557_abnormal_social/conspecific_i1.69715242
31MP0004924_abnormal_behavior1.63326049
32MP0005386_behavior/neurological_phenoty1.63326049
33MP0000013_abnormal_adipose_tissue1.62500610
34MP0005646_abnormal_pituitary_gland1.55941851
35MP0004043_abnormal_pH_regulation1.55360971
36MP0001502_abnormal_circadian_rhythm1.52212241
37MP0001984_abnormal_olfaction1.50533825
38MP0004811_abnormal_neuron_physiology1.50225593
39MP0000955_abnormal_spinal_cord1.48195567
40MP0004858_abnormal_nervous_system1.48191327
41MP0000569_abnormal_digit_pigmentation1.48018394
42MP0002066_abnormal_motor_capabilities/c1.45611432
43MP0008877_abnormal_DNA_methylation1.45130052
44MP0004885_abnormal_endolymph1.44029967
45MP0010386_abnormal_urinary_bladder1.43923621
46MP0003633_abnormal_nervous_system1.42450314
47MP0000778_abnormal_nervous_system1.42419495
48MP0004142_abnormal_muscle_tone1.42406273
49MP0002822_catalepsy1.41596290
50MP0001986_abnormal_taste_sensitivity1.34721812
51MP0002882_abnormal_neuron_morphology1.32427832
52MP0004147_increased_porphyrin_level1.23936905
53MP0005551_abnormal_eye_electrophysiolog1.23892696
54MP0003631_nervous_system_phenotype1.23106498
55MP0000751_myopathy1.15978437
56MP0006276_abnormal_autonomic_nervous1.14012351
57MP0003787_abnormal_imprinting1.13703803
58MP0004215_abnormal_myocardial_fiber1.13414035
59MP0003283_abnormal_digestive_organ1.13361221
60MP0004233_abnormal_muscle_weight1.11919466
61MP0001188_hyperpigmentation1.07866547
62MP0002229_neurodegeneration1.06010598
63MP0003632_abnormal_nervous_system1.05697818
64MP0002152_abnormal_brain_morphology1.02609856
65MP0006072_abnormal_retinal_apoptosis1.00092798
66MP0005167_abnormal_blood-brain_barrier0.98163412
67MP0004742_abnormal_vestibular_system0.96628120
68MP0005645_abnormal_hypothalamus_physiol0.96016417
69MP0002069_abnormal_eating/drinking_beha0.95469493
70MP0002638_abnormal_pupillary_reflex0.93151144
71MP0005535_abnormal_body_temperature0.91922650
72MP0000604_amyloidosis0.91462313
73MP0003183_abnormal_peptide_metabolism0.89939116
74MP0002102_abnormal_ear_morphology0.89683821
75MP0003634_abnormal_glial_cell0.86423538
76MP0002090_abnormal_vision0.84831262
77MP0005499_abnormal_olfactory_system0.84322711
78MP0005394_taste/olfaction_phenotype0.84322711
79MP0008872_abnormal_physiological_respon0.83505727
80MP0001529_abnormal_vocalization0.83213887
81MP0001963_abnormal_hearing_physiology0.83205200
82MP0003122_maternal_imprinting0.83154192
83MP0004484_altered_response_of0.82979919
84MP0004085_abnormal_heartbeat0.81073250
85MP0001905_abnormal_dopamine_level0.80796604
86MP0000920_abnormal_myelination0.80173535
87MP0003137_abnormal_impulse_conducting0.78281365
88MP0003690_abnormal_glial_cell0.78235781
89MP0008961_abnormal_basal_metabolism0.76693910
90MP0004036_abnormal_muscle_relaxation0.76564162
91MP0003646_muscle_fatigue0.75948803
92MP0002876_abnormal_thyroid_physiology0.74796687
93MP0000631_abnormal_neuroendocrine_gland0.73173562
94MP0008874_decreased_physiological_sensi0.71633497
95MP0001177_atelectasis0.70776987
96MP0003121_genomic_imprinting0.69792819
97MP0002653_abnormal_ependyma_morphology0.68649142
98MP0002752_abnormal_somatic_nervous0.67868948
99MP0000026_abnormal_inner_ear0.67794244
100MP0000747_muscle_weakness0.67593095
101MP0001299_abnormal_eye_distance/0.65974121
102MP0004130_abnormal_muscle_cell0.65296998
103MP0001485_abnormal_pinna_reflex0.64068177
104MP0004510_myositis0.63593820
105MP0003938_abnormal_ear_development0.61160748
106MP0005379_endocrine/exocrine_gland_phen0.61056706
107MP0001765_abnormal_ion_homeostasis0.59712451
108MP0002693_abnormal_pancreas_physiology0.59340540
109MP0003075_altered_response_to0.59112554
110MP0000749_muscle_degeneration0.58306964
111MP0002234_abnormal_pharynx_morphology0.56899291
112MP0005253_abnormal_eye_physiology0.56576661
113MP0001664_abnormal_digestion0.56190324
114MP0003195_calcinosis0.56006789
115MP0003123_paternal_imprinting0.52416001
116MP0010769_abnormal_survival0.52040044
117MP0010770_preweaning_lethality0.50188315
118MP0002082_postnatal_lethality0.50188315

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.53041542
2Visual hallucinations (HP:0002367)5.95625675
3Focal seizures (HP:0007359)5.43868461
4Atonic seizures (HP:0010819)5.40645199
5Myokymia (HP:0002411)5.38759577
6Epileptic encephalopathy (HP:0200134)5.27350955
7Febrile seizures (HP:0002373)5.03999010
8Progressive cerebellar ataxia (HP:0002073)5.01747172
9Action tremor (HP:0002345)4.82580188
10Absence seizures (HP:0002121)4.70841982
11Dialeptic seizures (HP:0011146)4.09786943
12Gaze-evoked nystagmus (HP:0000640)3.94078806
13Generalized tonic-clonic seizures (HP:0002069)3.91959045
14Dysdiadochokinesis (HP:0002075)3.68459725
15Broad-based gait (HP:0002136)3.62508295
16Limb dystonia (HP:0002451)3.51588516
17Impaired smooth pursuit (HP:0007772)3.47268207
18Dysmetria (HP:0001310)3.37308483
19Hyperventilation (HP:0002883)3.36624041
20Hemiparesis (HP:0001269)3.33817711
21Truncal ataxia (HP:0002078)3.32536262
22Poor eye contact (HP:0000817)3.27542585
23Diplopia (HP:0000651)3.26037317
24Abnormality of binocular vision (HP:0011514)3.26037317
25Scanning speech (HP:0002168)3.23710026
26Depression (HP:0000716)3.21823267
27Cerebral hypomyelination (HP:0006808)3.20256307
28Supranuclear gaze palsy (HP:0000605)3.13197559
29Impaired social interactions (HP:0000735)3.06852331
30Abnormal social behavior (HP:0012433)3.06852331
31Anxiety (HP:0000739)3.06050384
32Dysmetric saccades (HP:0000641)3.03449147
33Abnormality of ocular smooth pursuit (HP:0000617)2.99015025
34Epileptiform EEG discharges (HP:0011182)2.89077330
35Hemiplegia (HP:0002301)2.88091142
36Intention tremor (HP:0002080)2.83284496
37Genetic anticipation (HP:0003743)2.82384388
38Impaired vibration sensation in the lower limbs (HP:0002166)2.79952906
39EEG with generalized epileptiform discharges (HP:0011198)2.78522815
40Amblyopia (HP:0000646)2.72447886
41Status epilepticus (HP:0002133)2.71146437
42Abnormality of the lower motor neuron (HP:0002366)2.68767985
43Hypsarrhythmia (HP:0002521)2.60377767
44Drooling (HP:0002307)2.57446494
45Excessive salivation (HP:0003781)2.57446494
46Ankle clonus (HP:0011448)2.54726518
47Abnormal eating behavior (HP:0100738)2.54625798
48Postural instability (HP:0002172)2.54134427
49Pheochromocytoma (HP:0002666)2.52185169
50Neurofibrillary tangles (HP:0002185)2.51328569
51Cerebral inclusion bodies (HP:0100314)2.49575081
52Agitation (HP:0000713)2.40770418
53Exercise-induced myalgia (HP:0003738)2.38960134
54Polyphagia (HP:0002591)2.34459428
55Postural tremor (HP:0002174)2.32501396
56Gait ataxia (HP:0002066)2.30308881
57Urinary bladder sphincter dysfunction (HP:0002839)2.29114846
58Bradykinesia (HP:0002067)2.26928835
59Ventricular fibrillation (HP:0001663)2.25820784
60Absent speech (HP:0001344)2.25335409
61Neuroendocrine neoplasm (HP:0100634)2.22096529
62Limb ataxia (HP:0002070)2.20787063
63Spastic gait (HP:0002064)2.20714887
64CNS hypomyelination (HP:0003429)2.16342668
65Mutism (HP:0002300)2.16221148
66Spastic tetraplegia (HP:0002510)2.11900139
67Congenital stationary night blindness (HP:0007642)2.11484247
68Megalencephaly (HP:0001355)2.09571989
69Progressive inability to walk (HP:0002505)2.09319818
70Spastic tetraparesis (HP:0001285)2.08997681
71Stereotypic behavior (HP:0000733)2.08580582
72Impaired vibratory sensation (HP:0002495)2.07937981
73Amyotrophic lateral sclerosis (HP:0007354)2.07089277
74Fetal akinesia sequence (HP:0001989)2.04598421
75Tetraplegia (HP:0002445)2.02642871
76Psychosis (HP:0000709)2.02318154
77Abnormality of saccadic eye movements (HP:0000570)2.01403798
78Medial flaring of the eyebrow (HP:0010747)2.00267787
79Urinary urgency (HP:0000012)1.99965827
80Sleep apnea (HP:0010535)1.98600196
81Pancreatic cysts (HP:0001737)1.98528310
82Degeneration of the lateral corticospinal tracts (HP:0002314)1.98425863
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.98425863
84Generalized myoclonic seizures (HP:0002123)1.95907329
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.94833565
86Prolonged QT interval (HP:0001657)1.94662567
87Neuronal loss in central nervous system (HP:0002529)1.94041636
88Abnormality of the corticospinal tract (HP:0002492)1.92376368
89Specific learning disability (HP:0001328)1.92349259
90Delusions (HP:0000746)1.89801553
91Morphological abnormality of the pyramidal tract (HP:0002062)1.89247090
92Widely spaced teeth (HP:0000687)1.88752552
93Akinesia (HP:0002304)1.86988200
94Bundle branch block (HP:0011710)1.86943254
95Incomplete penetrance (HP:0003829)1.84277816
96Horizontal nystagmus (HP:0000666)1.81248648
97Increased circulating renin level (HP:0000848)1.81029782
98Lissencephaly (HP:0001339)1.80971016
99Central scotoma (HP:0000603)1.80969262
100Intellectual disability, severe (HP:0010864)1.80579145
101Papilledema (HP:0001085)1.79561842
102Dyskinesia (HP:0100660)1.78909056
103Retinal dysplasia (HP:0007973)1.78261241
104Myotonia (HP:0002486)1.77499401
105Choreoathetosis (HP:0001266)1.76929856
106Abnormal EKG (HP:0003115)1.76777094
107Focal dystonia (HP:0004373)1.76358395
108Lower limb asymmetry (HP:0100559)1.75948808
109Rigidity (HP:0002063)1.75456851
110Split foot (HP:0001839)1.75198937
111Craniofacial dystonia (HP:0012179)1.75112803
112Pancreatic fibrosis (HP:0100732)1.74202318
113True hermaphroditism (HP:0010459)1.73870406
114Hypoplasia of the corpus callosum (HP:0002079)1.73637053
115Progressive microcephaly (HP:0000253)1.72785276
116Spinal canal stenosis (HP:0003416)1.72284780
117Torticollis (HP:0000473)1.72209470
118Peripheral hypomyelination (HP:0007182)1.71957160
119Congenital primary aphakia (HP:0007707)1.71628182
120Gait imbalance (HP:0002141)1.71610145
121Cortical visual impairment (HP:0100704)1.71524141
122Termporal pattern (HP:0011008)1.71007834
123Insidious onset (HP:0003587)1.71007834
124Annular pancreas (HP:0001734)1.68937069
125Clonus (HP:0002169)1.66409665
126Lower limb muscle weakness (HP:0007340)1.66343785
127Inability to walk (HP:0002540)1.65477740
128Protruding tongue (HP:0010808)1.64532690
129Type II lissencephaly (HP:0007260)1.63532153
130Unsteady gait (HP:0002317)1.63361566
131Abnormality of salivation (HP:0100755)1.62979261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.37724278
2EPHA43.66530990
3MAP3K43.39828588
4MAP3K93.28394292
5FRK2.84585670
6RIPK42.83707692
7MAP2K72.72010086
8MINK12.42466466
9CAMKK22.38747211
10DAPK22.29540640
11PAK62.26584880
12MAP2K42.25521163
13CASK2.10349458
14MAP3K121.95024074
15CAMKK11.94005687
16PRKD31.92031072
17MARK11.91083302
18CDK191.81954185
19KSR21.70212703
20NTRK21.67816549
21NTRK11.67276779
22PNCK1.63545259
23PRPF4B1.63476213
24PLK21.58735034
25WNK31.53140133
26DAPK11.50713585
27STK381.48069631
28PRKCG1.45482149
29CDK51.44652858
30GRK51.43249555
31TNIK1.35037963
32BMPR21.34475302
33KSR11.27582825
34ARAF1.23399404
35PHKG21.18402581
36PHKG11.18402581
37PINK11.14665833
38INSRR1.09690636
39MAP3K21.09303805
40RIPK11.08574677
41SIK21.08376159
42MAP4K21.07313198
43UHMK11.06090034
44SGK4941.05845902
45SGK2231.05845902
46NME11.02772824
47OXSR11.02662791
48CAMK2A1.01175169
49CSNK1G21.00841193
50WNK11.00521875
51CAMK10.96630851
52MAP3K130.96074702
53MAPK130.95087897
54CAMK2B0.91472955
55CDK180.87249678
56CDK150.86717791
57BMPR1B0.86688033
58DYRK1A0.85523468
59SGK20.85097774
60PKN10.83956679
61TYRO30.83621645
62CDK140.80776538
63ADRBK20.79484021
64GRK10.78832240
65PRKCH0.78321747
66PTK2B0.77408507
67STK110.77081560
68FES0.75653382
69CDK11A0.74385352
70SGK10.73035186
71AKT30.72821157
72CCNB10.72468449
73FGFR20.71803095
74SGK30.70565866
75CAMK2D0.68123296
76PDK10.67994702
77CAMK2G0.67257315
78PRKCE0.66692929
79STK390.64819016
80PDPK10.64399819
81RAF10.63420306
82PAK30.63202619
83CDC42BPA0.63199514
84CSNK1G30.62804762
85RET0.62393646
86CAMK1G0.60057932
87TRIM280.60007257
88CSNK1A1L0.59139049
89MAP3K10.57854422
90DYRK20.57463248
91PRKCZ0.56761442
92BCR0.56594826
93WNK40.54727548
94NEK60.53815312
95RPS6KA30.51976748
96BRAF0.50714973
97CSNK1G10.50567096
98SCYL20.50396041
99FER0.50351234
100MAP3K70.49352762
101LIMK10.48971119
102SIK30.48355123
103MAPK120.48148324
104PDK30.48005778
105PDK40.48005778
106MARK20.45921531
107CAMK40.45758940
108ROCK20.44974819
109MAPK100.43775648
110ALK0.43179973
111TNK20.42414815
112CSNK1D0.41905325
113FYN0.41681201
114HIPK20.41238751
115DMPK0.40666219
116MAP2K60.40503834
117PRKACA0.40174124
118LATS20.40002378
119CSNK1A10.38853791
120MUSK0.38316922
121PRKG10.37462285
122MAPKAPK50.37225907
123PRKCA0.36843894
124ADRBK10.35756561
125EPHA30.34199160
126BRSK10.34135232
127NUAK10.33548915
128STK38L0.33195666
129PRKCB0.31467781
130PRKAA10.31367696

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.03830339
2Synaptic vesicle cycle_Homo sapiens_hsa047213.29427753
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.89216308
4Long-term potentiation_Homo sapiens_hsa047202.86820538
5GABAergic synapse_Homo sapiens_hsa047272.76722931
6Circadian entrainment_Homo sapiens_hsa047132.73704596
7Glutamatergic synapse_Homo sapiens_hsa047242.70454177
8Morphine addiction_Homo sapiens_hsa050322.44937910
9Amphetamine addiction_Homo sapiens_hsa050312.42868202
10Insulin secretion_Homo sapiens_hsa049112.37196093
11Salivary secretion_Homo sapiens_hsa049702.30803124
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28220881
13Taste transduction_Homo sapiens_hsa047422.09171326
14Long-term depression_Homo sapiens_hsa047302.07430253
15Olfactory transduction_Homo sapiens_hsa047402.06791100
16Dopaminergic synapse_Homo sapiens_hsa047281.99075257
17Gastric acid secretion_Homo sapiens_hsa049711.89701162
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.87909730
19Collecting duct acid secretion_Homo sapiens_hsa049661.77917407
20Cholinergic synapse_Homo sapiens_hsa047251.75541096
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64340518
22Renin secretion_Homo sapiens_hsa049241.63185305
23Oxytocin signaling pathway_Homo sapiens_hsa049211.61862923
24Calcium signaling pathway_Homo sapiens_hsa040201.60103866
25Serotonergic synapse_Homo sapiens_hsa047261.57008866
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55732814
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52839700
28Type II diabetes mellitus_Homo sapiens_hsa049301.39980154
29GnRH signaling pathway_Homo sapiens_hsa049121.32563809
30Cocaine addiction_Homo sapiens_hsa050301.31774599
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28496416
32Cardiac muscle contraction_Homo sapiens_hsa042601.26741035
33cAMP signaling pathway_Homo sapiens_hsa040241.24369179
34Vibrio cholerae infection_Homo sapiens_hsa051101.21588477
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20297852
36Gap junction_Homo sapiens_hsa045401.18919344
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17212692
38Pancreatic secretion_Homo sapiens_hsa049721.17014495
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16874774
40Estrogen signaling pathway_Homo sapiens_hsa049151.08820143
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01832114
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00842055
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97163035
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.97044125
45Thyroid hormone synthesis_Homo sapiens_hsa049180.96764539
46Vitamin B6 metabolism_Homo sapiens_hsa007500.93124705
47* Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87464318
48Glioma_Homo sapiens_hsa052140.87313028
49Melanogenesis_Homo sapiens_hsa049160.86859928
50beta-Alanine metabolism_Homo sapiens_hsa004100.81268443
51Glucagon signaling pathway_Homo sapiens_hsa049220.78546366
52Dilated cardiomyopathy_Homo sapiens_hsa054140.77611494
53Circadian rhythm_Homo sapiens_hsa047100.77219099
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76534907
55Ether lipid metabolism_Homo sapiens_hsa005650.76363284
56Oocyte meiosis_Homo sapiens_hsa041140.73739522
57Alzheimers disease_Homo sapiens_hsa050100.73711276
58ErbB signaling pathway_Homo sapiens_hsa040120.73149527
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68001134
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.67784232
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67128470
62Inositol phosphate metabolism_Homo sapiens_hsa005620.66321090
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66035183
64Regulation of autophagy_Homo sapiens_hsa041400.65567568
65Axon guidance_Homo sapiens_hsa043600.64537454
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.62933445
67Type I diabetes mellitus_Homo sapiens_hsa049400.61818765
68Dorso-ventral axis formation_Homo sapiens_hsa043200.61115958
69Choline metabolism in cancer_Homo sapiens_hsa052310.59082460
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58874942
71MAPK signaling pathway_Homo sapiens_hsa040100.57997435
72Oxidative phosphorylation_Homo sapiens_hsa001900.57451041
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56679541
74Linoleic acid metabolism_Homo sapiens_hsa005910.56230546
75Phototransduction_Homo sapiens_hsa047440.55609052
76Nitrogen metabolism_Homo sapiens_hsa009100.55471111
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53855812
78Bile secretion_Homo sapiens_hsa049760.50887417
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50210403
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50031361
81mTOR signaling pathway_Homo sapiens_hsa041500.49618051
82ABC transporters_Homo sapiens_hsa020100.49129737
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48714684
84Histidine metabolism_Homo sapiens_hsa003400.48305335
85VEGF signaling pathway_Homo sapiens_hsa043700.45094579
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42711859
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42565188
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42273989
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40877253
90Fatty acid biosynthesis_Homo sapiens_hsa000610.40192494
91Mineral absorption_Homo sapiens_hsa049780.39816159
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39409964
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.39089233
94Ras signaling pathway_Homo sapiens_hsa040140.37280321
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.37111522
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36770106
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36525518
98Alcoholism_Homo sapiens_hsa050340.36390397
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34975617
100Insulin signaling pathway_Homo sapiens_hsa049100.34795465
101Arginine and proline metabolism_Homo sapiens_hsa003300.34641524
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34149247
103Rap1 signaling pathway_Homo sapiens_hsa040150.33372331
104Tryptophan metabolism_Homo sapiens_hsa003800.32490674
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32230023
106African trypanosomiasis_Homo sapiens_hsa051430.30533597
107Endocytosis_Homo sapiens_hsa041440.30487527
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28177264
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27083306
110Ovarian steroidogenesis_Homo sapiens_hsa049130.26113991
111Parkinsons disease_Homo sapiens_hsa050120.24731580
112Propanoate metabolism_Homo sapiens_hsa006400.24634769
113Renal cell carcinoma_Homo sapiens_hsa052110.24058557
114Wnt signaling pathway_Homo sapiens_hsa043100.22607733
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21030602
116Prion diseases_Homo sapiens_hsa050200.21013662
117Butanoate metabolism_Homo sapiens_hsa006500.20843068
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18557322

Most similar genes based on co-expression Upload to Enrichr

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