ST8SIA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycosyltransferase 29 protein family. Members of this protein family synthesize sialylglycoconjugates. Sialylation may contribute to multidrug resistance in cancer cells. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of oxidative stress-induced neuron death (GO:1903203)6.57358648
2positive regulation of cellular response to oxidative stress (GO:1900409)5.62814741
3positive regulation of response to oxidative stress (GO:1902884)5.62814741
4response to interleukin-15 (GO:0070672)5.40506181
5angiogenesis involved in wound healing (GO:0060055)5.35183064
6positive regulation of gamma-delta T cell activation (GO:0046645)5.29862605
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.16435735
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.16435735
9antigen processing and presentation of endogenous antigen (GO:0019883)5.16268091
10aggressive behavior (GO:0002118)5.09235082
11myoblast migration (GO:0051451)5.04663076
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.86264234
13negative regulation of cell killing (GO:0031342)4.86264234
14positive regulation of hormone biosynthetic process (GO:0046886)4.78616732
15regulation of T cell tolerance induction (GO:0002664)4.66900616
16thrombin receptor signaling pathway (GO:0070493)4.65591827
17positive thymic T cell selection (GO:0045059)4.55232693
18negative thymic T cell selection (GO:0045060)4.55024126
19regulation of gamma-delta T cell differentiation (GO:0045586)4.41825947
20regulation of female receptivity (GO:0045924)4.40248433
21energy homeostasis (GO:0097009)4.39783031
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.35621403
23embryonic process involved in female pregnancy (GO:0060136)4.32794381
24monocyte differentiation (GO:0030224)4.31374614
25negative T cell selection (GO:0043383)4.28385139
26positive regulation of endothelial cell differentiation (GO:0045603)4.17302290
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.05379822
28female mating behavior (GO:0060180)4.03537614
29pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.02469907
30positive regulation of tolerance induction (GO:0002645)4.01241346
31type B pancreatic cell development (GO:0003323)3.99104440
32regulation of B cell receptor signaling pathway (GO:0050855)3.98057631
33regulation of gamma-delta T cell activation (GO:0046643)3.96134045
34regulation of isotype switching to IgG isotypes (GO:0048302)3.88085105
35thymic T cell selection (GO:0045061)3.86161662
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.83875353
37regulation of histone H3-K27 methylation (GO:0061085)3.78316760
38positive regulation of B cell differentiation (GO:0045579)3.76698423
39deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76162805
40regulation of histone H3-K9 methylation (GO:0051570)3.73114320
41negative regulation of fatty acid transport (GO:2000192)3.70439290
42mucosal-associated lymphoid tissue development (GO:0048537)3.69636913
43Peyers patch development (GO:0048541)3.69636913
44embryonic hemopoiesis (GO:0035162)3.67192696
45megakaryocyte development (GO:0035855)3.66027278
46regulation of erythrocyte differentiation (GO:0045646)3.65478609
47T cell costimulation (GO:0031295)3.65225428
48positive regulation of hormone metabolic process (GO:0032352)3.64701910
49negative regulation of erythrocyte differentiation (GO:0045647)3.64018781
50regulation of tolerance induction (GO:0002643)3.62884827
51granulocyte differentiation (GO:0030851)3.61215067
52regulation of endothelial cell differentiation (GO:0045601)3.59956282
53lymphocyte costimulation (GO:0031294)3.57237001
54positive regulation of histone deacetylation (GO:0031065)3.53537259
55positive regulation of granulocyte differentiation (GO:0030854)3.53067525
56positive regulation of endothelial cell apoptotic process (GO:2000353)3.51862687
57T cell selection (GO:0045058)3.51344781
58regulation of interleukin-12 biosynthetic process (GO:0045075)3.49330989
59positive T cell selection (GO:0043368)3.45014642
60NIK/NF-kappaB signaling (GO:0038061)3.43996624
61base-excision repair, AP site formation (GO:0006285)3.41800990
62grooming behavior (GO:0007625)3.41685217
63pyrimidine dimer repair (GO:0006290)3.41008795
64regulation of response to interferon-gamma (GO:0060330)3.38636533
65positive regulation of keratinocyte differentiation (GO:0045618)3.35265449
66natural killer cell differentiation (GO:0001779)3.34959631
67phospholipid scrambling (GO:0017121)3.34376767
68negative regulation of B cell proliferation (GO:0030889)3.33556825
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.33530614
70cellular response to interleukin-15 (GO:0071350)3.31987812
71DNA deamination (GO:0045006)3.31154362
72regulation of B cell differentiation (GO:0045577)3.28927882
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.28596962
74positive regulation of histone H3-K4 methylation (GO:0051571)3.26599975
75hepatocyte apoptotic process (GO:0097284)3.26561323
76mRNA splice site selection (GO:0006376)3.25590039
77negative regulation of mRNA processing (GO:0050686)3.25360656
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.23957358
79pyrimidine nucleotide catabolic process (GO:0006244)3.23293351
80dendritic cell chemotaxis (GO:0002407)3.21925270
81B cell receptor signaling pathway (GO:0050853)3.21830860
822-deoxyribonucleotide biosynthetic process (GO:0009265)3.21743235
83deoxyribose phosphate biosynthetic process (GO:0046385)3.21743235
84negative regulation of necroptotic process (GO:0060546)3.21377739
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21301066
86mitochondrial respiratory chain complex I assembly (GO:0032981)3.21301066
87NADH dehydrogenase complex assembly (GO:0010257)3.21301066
88maternal behavior (GO:0042711)3.20146123
89negative regulation of telomere maintenance (GO:0032205)3.18839245
90regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.18137448
91positive regulation of DNA-dependent DNA replication (GO:2000105)3.17538381
92regulation of megakaryocyte differentiation (GO:0045652)3.16153831
93pseudouridine synthesis (GO:0001522)3.15505866
94negative regulation of anoikis (GO:2000811)3.15401553
95ventricular trabecula myocardium morphogenesis (GO:0003222)3.14346847
96positive regulation of megakaryocyte differentiation (GO:0045654)3.13476379
97endothelial tube morphogenesis (GO:0061154)3.12716903
98morphogenesis of an endothelium (GO:0003159)3.12716903
99protein complex biogenesis (GO:0070271)3.12182972
100parental behavior (GO:0060746)3.10473006
101positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.10303537
102regulation of necroptotic process (GO:0060544)3.09841304
103positive regulation of erythrocyte differentiation (GO:0045648)3.08410347
104lamellipodium assembly (GO:0030032)3.08156819
105leukocyte aggregation (GO:0070486)3.05598607
106iron-sulfur cluster assembly (GO:0016226)3.04726521
107metallo-sulfur cluster assembly (GO:0031163)3.04726521
108regulation of steroid hormone biosynthetic process (GO:0090030)3.04533045
109ubiquinone biosynthetic process (GO:0006744)3.04352680
110definitive hemopoiesis (GO:0060216)3.04037655
111positive regulation of protein import into nucleus, translocation (GO:0033160)3.03312368
112cellular hyperosmotic response (GO:0071474)3.01200900
113positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.00347706
114positive regulation of lamellipodium organization (GO:1902745)3.00257031
115platelet dense granule organization (GO:0060155)2.98488677
116valine metabolic process (GO:0006573)2.97070824
117positive regulation of steroid hormone secretion (GO:2000833)2.96818366
118negative regulation of viral release from host cell (GO:1902187)2.96490752
119GMP metabolic process (GO:0046037)2.95002047
120positive regulation of steroid biosynthetic process (GO:0010893)2.94739151
121protoporphyrinogen IX metabolic process (GO:0046501)2.93629511
122negative regulation of mast cell activation (GO:0033004)2.93416796
123lamellipodium organization (GO:0097581)2.92472078
124regulation of T cell receptor signaling pathway (GO:0050856)2.91814867
125glandular epithelial cell development (GO:0002068)2.90495561
126deoxyribonucleotide catabolic process (GO:0009264)2.89518968
127positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.89414008
128purinergic nucleotide receptor signaling pathway (GO:0035590)2.88873757
129antigen receptor-mediated signaling pathway (GO:0050851)2.88847643
130positive regulation of prostaglandin secretion (GO:0032308)2.88379433
131dendritic cell migration (GO:0036336)2.87310155
132endothelium development (GO:0003158)2.86847194
133trabecula morphogenesis (GO:0061383)2.86753784
1342-deoxyribonucleotide metabolic process (GO:0009394)2.86734471
135fucose catabolic process (GO:0019317)2.85911498
136L-fucose metabolic process (GO:0042354)2.85911498
137L-fucose catabolic process (GO:0042355)2.85911498
138growth hormone receptor signaling pathway (GO:0060396)2.85891185
139regulation of transmission of nerve impulse (GO:0051969)2.84624908
140negative regulation of RNA splicing (GO:0033119)2.84503151
141mitochondrial respiratory chain complex assembly (GO:0033108)2.83131801
142T cell receptor signaling pathway (GO:0050852)2.83101676
143regulation of RIG-I signaling pathway (GO:0039535)2.82217824
144protoporphyrinogen IX biosynthetic process (GO:0006782)2.80961108
145regulation of histone H3-K4 methylation (GO:0051569)2.80548760
146positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.79250061
147response to magnesium ion (GO:0032026)2.79022143
148response to muramyl dipeptide (GO:0032495)2.78327100
149deoxyribose phosphate catabolic process (GO:0046386)2.77786822
150negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.75637419
151deoxyribose phosphate metabolic process (GO:0019692)2.75153799
152response to lipoprotein particle (GO:0055094)2.74488706
153positive regulation of histone methylation (GO:0031062)2.74477756
154preassembly of GPI anchor in ER membrane (GO:0016254)2.74454739
155negative regulation of protein oligomerization (GO:0032460)2.74262061
156T cell homeostasis (GO:0043029)2.73096194
157positive regulation of isotype switching (GO:0045830)2.72908640
158lymphocyte homeostasis (GO:0002260)2.72830489
159negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.72442739
160regulation of corticosteroid hormone secretion (GO:2000846)2.70714993
161positive regulation of Rap GTPase activity (GO:0032854)2.70491009
162heart trabecula morphogenesis (GO:0061384)2.69852804
163cytochrome complex assembly (GO:0017004)2.69516065
164positive regulation of amino acid transport (GO:0051957)2.69379044
165positive regulation of protein deacetylation (GO:0090312)2.69048768
166monoamine transport (GO:0015844)2.68851071
167ubiquinone metabolic process (GO:0006743)2.68389595
168seminiferous tubule development (GO:0072520)2.68293237
169piRNA metabolic process (GO:0034587)2.66503011
170mismatch repair (GO:0006298)2.65385521
171rRNA modification (GO:0000154)2.64982948
172interkinetic nuclear migration (GO:0022027)2.62700753
173hyperosmotic salinity response (GO:0042538)2.62461976
174DNA double-strand break processing (GO:0000729)2.59321260
175positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.58074080
176regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.58074080
177inositol metabolic process (GO:0006020)2.57921167
178purine-containing compound salvage (GO:0043101)2.57487076
179single strand break repair (GO:0000012)2.55911034
180negative regulation of mRNA metabolic process (GO:1903312)2.55873424
181regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.55288694
182replication fork processing (GO:0031297)2.54963124
183maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54492587
184GTP biosynthetic process (GO:0006183)2.51464497
185negative regulation of JAK-STAT cascade (GO:0046426)2.50713344
186postreplication repair (GO:0006301)2.49310866
187deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.49192750
188erythrocyte maturation (GO:0043249)2.47923550
189adenosine metabolic process (GO:0046085)2.46697581
190pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.44782234
191autophagic vacuole fusion (GO:0000046)2.44291690
192regulation of B cell apoptotic process (GO:0002902)2.42548011
193positive regulation of organic acid transport (GO:0032892)2.42547046
194detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.40690889
195negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.40288742

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human5.89588251
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.85825061
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.40008955
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.31269472
5SMAD_19615063_ChIP-ChIP_OVARY_Human4.09009253
6* RUNX_20019798_ChIP-Seq_JUKART_Human3.85615074
7E2F7_22180533_ChIP-Seq_HELA_Human3.63218854
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.56263813
9ZNF274_21170338_ChIP-Seq_K562_Hela3.53891652
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.51882848
11IRF8_22096565_ChIP-ChIP_GC-B_Human3.31955836
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.21539144
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13645791
14IGF1R_20145208_ChIP-Seq_DFB_Human3.07381915
15IRF8_21731497_ChIP-ChIP_J774_Mouse3.04741709
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.84276108
17VDR_22108803_ChIP-Seq_LS180_Human2.83327190
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.81039576
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.75790098
20* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.67998652
21* MYB_26560356_Chip-Seq_TH2_Human2.67209248
22* IRF8_27001747_Chip-Seq_BMDM_Mouse2.64230038
23SCL_19346495_ChIP-Seq_HPC-7_Human2.63642540
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.63623802
25MAF_26560356_Chip-Seq_TH1_Human2.60823035
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.58469506
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54173414
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52634378
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51614808
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47027892
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39381771
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34005161
33MYB_26560356_Chip-Seq_TH1_Human2.29670693
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25696401
35MYC_22102868_ChIP-Seq_BL_Human2.21478596
36MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17082225
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.13175541
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12916863
39SPI1_23127762_ChIP-Seq_K562_Human2.11837914
40IRF1_19129219_ChIP-ChIP_H3396_Human2.06609860
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.02495763
42TCF7_22412390_ChIP-Seq_EML_Mouse1.96571405
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.93381652
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92651481
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.90277583
46UTX_26944678_Chip-Seq_JUKART_Human1.86639415
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85261137
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83965903
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83230634
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.80743663
51TP53_22573176_ChIP-Seq_HFKS_Human1.80243479
52GATA3_27048872_Chip-Seq_THYMUS_Human1.78011210
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.77990391
54VDR_23849224_ChIP-Seq_CD4+_Human1.75347918
55EWS_26573619_Chip-Seq_HEK293_Human1.71206654
56KDM2B_26808549_Chip-Seq_DND41_Human1.70514930
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.67730566
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66713423
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63267753
60FOXP3_21729870_ChIP-Seq_TREG_Human1.63190529
61VDR_21846776_ChIP-Seq_THP-1_Human1.62493555
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.58315683
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58258520
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58236389
65GBX2_23144817_ChIP-Seq_PC3_Human1.56931623
66SPI1_23547873_ChIP-Seq_NB4_Human1.54271361
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54201376
68FUS_26573619_Chip-Seq_HEK293_Human1.52375712
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50983685
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.50926411
71VDR_24763502_ChIP-Seq_THP-1_Human1.50036015
72* KDM2B_26808549_Chip-Seq_JURKAT_Human1.48740653
73MYC_18940864_ChIP-ChIP_HL60_Human1.48441440
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47173574
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44919600
76ER_23166858_ChIP-Seq_MCF-7_Human1.42156205
77* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41487443
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39796636
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.39702406
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39147983
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38997164
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.37011047
83ELK1_19687146_ChIP-ChIP_HELA_Human1.36195700
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34136296
85* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32967691
86PU_27001747_Chip-Seq_BMDM_Mouse1.32528331
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29843672
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28797178
89GABP_17652178_ChIP-ChIP_JURKAT_Human1.28613189
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28225594
91FOXO3_23340844_ChIP-Seq_DLD1_Human1.28169803
92GATA1_22025678_ChIP-Seq_K562_Human1.28069115
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.27195279
94RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26752341
95CLOCK_20551151_ChIP-Seq_293T_Human1.26435482
96* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22959278
97* CBP_20019798_ChIP-Seq_JUKART_Human1.22959278
98FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.21840961
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21804428
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20729884
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20237934
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19276881
103PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18779679
104WT1_19549856_ChIP-ChIP_CCG9911_Human1.18302512
105MAF_26560356_Chip-Seq_TH2_Human1.18224252
106* NANOG_19829295_ChIP-Seq_ESCs_Human1.15475079
107* SOX2_19829295_ChIP-Seq_ESCs_Human1.15475079
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15126823
109CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14578272
110HTT_18923047_ChIP-ChIP_STHdh_Human1.14538653
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.12671515
112GATA3_21878914_ChIP-Seq_MCF-7_Human1.12544125
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10696858
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09894896
115TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09497845
116ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09377967
117VDR_24787735_ChIP-Seq_THP-1_Human1.08581732
118RXR_22108803_ChIP-Seq_LS180_Human1.05396691
119GATA3_26560356_Chip-Seq_TH2_Human1.05072426
120FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03480338
121AR_20517297_ChIP-Seq_VCAP_Human1.01190826
122GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00865575
123ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99255059
124* GATA2_19941826_ChIP-Seq_K562_Human0.98930627
125EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98467462
126LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97723810
127CIITA_25753668_ChIP-Seq_RAJI_Human0.97323502
128PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97192868
129P300_19829295_ChIP-Seq_ESCs_Human0.96874341
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95268295
131GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94769203
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94658760
133FLI1_21867929_ChIP-Seq_TH2_Mouse0.92456292
134FLI1_27457419_Chip-Seq_LIVER_Mouse0.92400058
135PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92192473
136TP53_16413492_ChIP-PET_HCT116_Human0.91053116
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90995497
138* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89994786
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89527758
140ZNF263_19887448_ChIP-Seq_K562_Human0.89231542
141FOXA1_25329375_ChIP-Seq_VCAP_Human0.89223960
142FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89223960
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89203354
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88911285
145* NCOR_22424771_ChIP-Seq_293T_Human0.88648676
146* KDM5A_27292631_Chip-Seq_BREAST_Human0.88410458
147NANOG_20526341_ChIP-Seq_ESCs_Human0.88027192
148CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87150346
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86987966
150* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86642704
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85517564
152EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84786320
153GATA6_25053715_ChIP-Seq_YYC3_Human0.83800435
154CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83364192
155STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83312572
156PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82909184
157PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82798033
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82381342
159LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82380588
160* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80695300
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80309979
162SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79962941
163SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79962941
164NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.76912753
165* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76080331
166RUNX1_27514584_Chip-Seq_MCF-7_Human0.75118864
167* ELF5_23300383_ChIP-Seq_T47D_Human0.72218704
168* GATA1_19941826_ChIP-Seq_K562_Human0.71531321
169SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.71276584
170GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.70359823
171FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69224051
172CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.68539720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.16062773
2MP0004147_increased_porphyrin_level3.69635573
3MP0002396_abnormal_hematopoietic_system3.67997666
4MP0000685_abnormal_immune_system3.67458933
5MP0001800_abnormal_humoral_immune3.62619029
6MP0001790_abnormal_immune_system3.21676536
7MP0005387_immune_system_phenotype3.21676536
8MP0009278_abnormal_bone_marrow3.10689988
9MP0002452_abnormal_antigen_presenting2.84266859
10MP0005646_abnormal_pituitary_gland2.74893623
11MP0008058_abnormal_DNA_repair2.72963273
12MP0003724_increased_susceptibility_to2.72823466
13MP0004264_abnormal_extraembryonic_tissu2.61194697
14MP0003300_gastrointestinal_ulcer2.59041200
15MP0002723_abnormal_immune_serum2.56358857
16MP0003763_abnormal_thymus_physiology2.53622928
17MP0005645_abnormal_hypothalamus_physiol2.51124156
18MP0002420_abnormal_adaptive_immunity2.49363431
19MP0001819_abnormal_immune_cell2.47920788
20MP0002398_abnormal_bone_marrow2.47191073
21MP0001968_abnormal_touch/_nociception2.46762158
22MP0005671_abnormal_response_to2.43130169
23MP0002166_altered_tumor_susceptibility2.42837534
24MP0008057_abnormal_DNA_replication2.40951283
25MP0006276_abnormal_autonomic_nervous2.34367671
26MP0002736_abnormal_nociception_after2.33090344
27MP0002138_abnormal_hepatobiliary_system2.28465502
28MP0005000_abnormal_immune_tolerance2.25007114
29MP0010155_abnormal_intestine_physiology2.22922956
30MP0000716_abnormal_immune_system2.17414792
31MP0003806_abnormal_nucleotide_metabolis2.15160736
32MP0001879_abnormal_lymphatic_vessel2.09703177
33MP0003045_fibrosis2.07712693
34MP0003303_peritoneal_inflammation2.06182935
35MP0005025_abnormal_response_to1.95876663
36MP0000372_irregular_coat_pigmentation1.95254930
37MP0001851_eye_inflammation1.92398046
38MP0002405_respiratory_system_inflammati1.88286673
39MP0004185_abnormal_adipocyte_glucose1.86662044
40MP0002419_abnormal_innate_immunity1.85462962
41MP0000689_abnormal_spleen_morphology1.85312035
42MP0002429_abnormal_blood_cell1.83806868
43MP0004947_skin_inflammation1.82579991
44MP0002722_abnormal_immune_system1.80748472
45MP0008872_abnormal_physiological_respon1.80723792
46MP0002006_tumorigenesis1.80139751
47MP0008877_abnormal_DNA_methylation1.79903735
48MP0001873_stomach_inflammation1.78835087
49MP0006054_spinal_hemorrhage1.78699151
50MP0005084_abnormal_gallbladder_morpholo1.77481264
51MP0000703_abnormal_thymus_morphology1.75502534
52MP0008961_abnormal_basal_metabolism1.68597904
53MP0002148_abnormal_hypersensitivity_rea1.65550635
54MP0005075_abnormal_melanosome_morpholog1.64550929
55MP0005464_abnormal_platelet_physiology1.63094063
56MP0003718_maternal_effect1.59685971
57MP0002102_abnormal_ear_morphology1.58856215
58MP0002009_preneoplasia1.58470531
59MP0004808_abnormal_hematopoietic_stem1.56475632
60MP0001845_abnormal_inflammatory_respons1.53491189
61MP0006036_abnormal_mitochondrial_physio1.51714541
62MP0008995_early_reproductive_senescence1.51005779
63MP0010094_abnormal_chromosome_stability1.50956449
64MP0004510_myositis1.49733455
65MP0001853_heart_inflammation1.49338716
66MP0000015_abnormal_ear_pigmentation1.48597591
67MP0005310_abnormal_salivary_gland1.46685027
68MP0008775_abnormal_heart_ventricle1.46318683
69MP0003436_decreased_susceptibility_to1.45101673
70MP0002234_abnormal_pharynx_morphology1.44983440
71MP0008004_abnormal_stomach_pH1.42261096
72MP0010234_abnormal_vibrissa_follicle1.39846098
73MP0005410_abnormal_fertilization1.39579434
74MP0004233_abnormal_muscle_weight1.37629588
75MP0010352_gastrointestinal_tract_polyps1.37329714
76MP0005076_abnormal_cell_differentiation1.36110813
77MP0005670_abnormal_white_adipose1.34841231
78MP0002735_abnormal_chemical_nociception1.32905006
79MP0006082_CNS_inflammation1.30214783
80MP0003787_abnormal_imprinting1.30102564
81MP0005551_abnormal_eye_electrophysiolog1.28063373
82MP0003566_abnormal_cell_adhesion1.27669993
83MP0004145_abnormal_muscle_electrophysio1.27499687
84MP0005174_abnormal_tail_pigmentation1.25427149
85MP0002733_abnormal_thermal_nociception1.24763024
86MP0000858_altered_metastatic_potential1.24653040
87MP0005367_renal/urinary_system_phenotyp1.22274226
88MP0000516_abnormal_urinary_system1.22274226
89MP0009697_abnormal_copulation1.21729234
90MP0002132_abnormal_respiratory_system1.20698733
91MP0000767_abnormal_smooth_muscle1.20589672
92MP0003866_abnormal_defecation1.20315878
93MP0001664_abnormal_digestion1.20199212
94MP0008789_abnormal_olfactory_epithelium1.17379408
95MP0005083_abnormal_biliary_tract1.14471646
96MP0009785_altered_susceptibility_to1.12971796
97MP0002095_abnormal_skin_pigmentation1.11683168
98MP0005220_abnormal_exocrine_pancreas1.11176232
99MP0003646_muscle_fatigue1.08685203
100MP0003880_abnormal_central_pattern1.08494906
101MP0003943_abnormal_hepatobiliary_system1.07429660
102MP0002136_abnormal_kidney_physiology1.06963034
103MP0001533_abnormal_skeleton_physiology1.06693466
104MP0009765_abnormal_xenobiotic_induced1.05048328
105MP0000230_abnormal_systemic_arterial1.03654430
106MP0006292_abnormal_olfactory_placode1.02835048
107MP0000465_gastrointestinal_hemorrhage1.02120552
108MP0001986_abnormal_taste_sensitivity1.01956815
109MP0009333_abnormal_splenocyte_physiolog1.01122315
110MP0003786_premature_aging1.00439916
111MP0000490_abnormal_crypts_of1.00388971
112MP0005666_abnormal_adipose_tissue0.99751403
113MP0001661_extended_life_span0.99737131
114MP0002160_abnormal_reproductive_system0.97408737
115MP0004142_abnormal_muscle_tone0.96831388
116MP0005636_abnormal_mineral_homeostasis0.95302763
117MP0003091_abnormal_cell_migration0.95166866
118MP0002933_joint_inflammation0.95053083
119MP0001958_emphysema0.93195242
120MP0002928_abnormal_bile_duct0.88946975
121MP0004043_abnormal_pH_regulation0.88675316
122MP0001881_abnormal_mammary_gland0.86091452
123MP0003186_abnormal_redox_activity0.85489364
124MP0005389_reproductive_system_phenotype0.84499514
125MP0005266_abnormal_metabolism0.82792133
126MP0000681_abnormal_thyroid_gland0.82613017
127MP0003656_abnormal_erythrocyte_physiolo0.82588724
128MP0005397_hematopoietic_system_phenotyp0.82358931
129MP0001545_abnormal_hematopoietic_system0.82358931
130MP0008469_abnormal_protein_level0.82336478
131MP0001929_abnormal_gametogenesis0.81930269
132MP0001764_abnormal_homeostasis0.81818322
133MP0003698_abnormal_male_reproductive0.81790270
134MP0008873_increased_physiological_sensi0.81096260
135MP0009643_abnormal_urine_homeostasis0.80871819
136MP0001765_abnormal_ion_homeostasis0.80303255
137MP0005165_increased_susceptibility_to0.79125336
138MP0000569_abnormal_digit_pigmentation0.76845096
139MP0003638_abnormal_response/metabolism_0.76257583
140MP0004130_abnormal_muscle_cell0.76018822
141MP0006072_abnormal_retinal_apoptosis0.75501750
142MP0000249_abnormal_blood_vessel0.75017960
143MP0003828_pulmonary_edema0.74601570
144MP0002168_other_aberrant_phenotype0.73575957
145MP0001970_abnormal_pain_threshold0.73212852
146MP0002837_dystrophic_cardiac_calcinosis0.72588896
147MP0005167_abnormal_blood-brain_barrier0.71941582
148MP0000631_abnormal_neuroendocrine_gland0.71526544
149MP0003453_abnormal_keratinocyte_physiol0.70804299
150MP0001529_abnormal_vocalization0.70359361
151MP0006035_abnormal_mitochondrial_morpho0.69576016
152MP0005164_abnormal_response_to0.67091820
153MP0009764_decreased_sensitivity_to0.66569749
154MP0005058_abnormal_lysosome_morphology0.65683027
155MP0010368_abnormal_lymphatic_system0.65639253
156MP0003191_abnormal_cellular_cholesterol0.64640376
157MP0005023_abnormal_wound_healing0.64369014
158MP0008875_abnormal_xenobiotic_pharmacok0.64213305
159MP0002925_abnormal_cardiovascular_devel0.64127716
160MP0002019_abnormal_tumor_incidence0.63839713
161MP0003448_altered_tumor_morphology0.63053316
162MP0002998_abnormal_bone_remodeling0.62278012
163MP0008007_abnormal_cellular_replicative0.62189441
164MP0000653_abnormal_sex_gland0.62078843
165MP0001915_intracranial_hemorrhage0.62078373
166MP0005499_abnormal_olfactory_system0.61625559
167MP0005394_taste/olfaction_phenotype0.61625559
168MP0000343_altered_response_to0.61205836
169MP0002086_abnormal_extraembryonic_tissu0.59187681
170MP0005535_abnormal_body_temperature0.58882985
171MP0001188_hyperpigmentation0.58587420
172MP0003111_abnormal_nucleus_morphology0.58308128
173MP0000371_diluted_coat_color0.56838397
174MP0009115_abnormal_fat_cell0.56688183

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.76751510
2Alveolar cell carcinoma (HP:0006519)5.22613361
3Neoplasm of the tracheobronchial system (HP:0100552)5.00305687
4Agammaglobulinemia (HP:0004432)4.88643175
5Colitis (HP:0002583)4.73844346
6Petechiae (HP:0000967)4.50362732
7IgM deficiency (HP:0002850)4.16534439
8Nasal polyposis (HP:0100582)4.07675892
9Absent rod-and cone-mediated responses on ERG (HP:0007688)4.03864291
10Toxemia of pregnancy (HP:0100603)4.01173558
11Abnormality of the nasal mucosa (HP:0000433)3.87892620
12Disinhibition (HP:0000734)3.80884833
13Recurrent viral infections (HP:0004429)3.79121003
14Volvulus (HP:0002580)3.68597088
15Easy fatigability (HP:0003388)3.66734356
16Mutism (HP:0002300)3.63106370
17Inflammation of the large intestine (HP:0002037)3.60179054
18Autoimmune hemolytic anemia (HP:0001890)3.57515867
19Recurrent bronchitis (HP:0002837)3.48452779
20Recurrent fungal infections (HP:0002841)3.46066292
21Gastrointestinal inflammation (HP:0004386)3.37173058
22Abnormal rod and cone electroretinograms (HP:0008323)3.36837350
23Pustule (HP:0200039)3.35630243
24Cellulitis (HP:0100658)3.31858480
25Tubulointerstitial nephritis (HP:0001970)3.31824754
26Metaphyseal dysplasia (HP:0100255)3.26203383
27Stomatitis (HP:0010280)3.25115536
28Increased mean platelet volume (HP:0011877)3.21116186
29Abnormality of lateral ventricle (HP:0030047)3.19574723
30Epistaxis (HP:0000421)3.18246304
31Abnormal delayed hypersensitivity skin test (HP:0002963)3.16540322
32Renal cortical cysts (HP:0000803)3.16182434
33Constricted visual fields (HP:0001133)3.13439407
34Abnormal platelet volume (HP:0011876)3.08426076
35Chronic otitis media (HP:0000389)3.07640674
36Gastrointestinal stroma tumor (HP:0100723)3.03844242
37Abnormality of the renal cortex (HP:0011035)3.03740777
38Papilloma (HP:0012740)3.01582187
39Verrucae (HP:0200043)3.01582187
40Chronic mucocutaneous candidiasis (HP:0002728)2.99268160
41Recurrent cutaneous fungal infections (HP:0011370)2.99268160
42Acute lymphatic leukemia (HP:0006721)2.98497453
43Abnormality of the fingertips (HP:0001211)2.98392397
44Menorrhagia (HP:0000132)2.98297400
45Fatigable weakness (HP:0003473)2.97128051
46Abnormality of the neuromuscular junction (HP:0003398)2.97128051
47Dyschromatopsia (HP:0007641)2.95931432
48Recurrent abscess formation (HP:0002722)2.94683492
49Abnormality of the prostate (HP:0008775)2.90120203
50Panhypogammaglobulinemia (HP:0003139)2.89550109
51Reduced subcutaneous adipose tissue (HP:0003758)2.88671021
52Eczematoid dermatitis (HP:0000976)2.84571699
53Congenital stationary night blindness (HP:0007642)2.82934817
54Pancreatic cysts (HP:0001737)2.82496657
55Viral hepatitis (HP:0006562)2.82223151
56Large earlobe (HP:0009748)2.81407941
57Recurrent sinusitis (HP:0011108)2.80560083
58Pancreatic fibrosis (HP:0100732)2.80168076
59Recurrent bacterial skin infections (HP:0005406)2.79156529
60Decreased muscle mass (HP:0003199)2.76532955
61Interstitial pulmonary disease (HP:0006530)2.75570904
62Attenuation of retinal blood vessels (HP:0007843)2.74378933
63Myositis (HP:0100614)2.71758148
64Elevated erythrocyte sedimentation rate (HP:0003565)2.66954133
65Persistence of primary teeth (HP:0006335)2.59066162
663-Methylglutaconic aciduria (HP:0003535)2.58795900
67Abolished electroretinogram (ERG) (HP:0000550)2.58579143
68Chronic diarrhea (HP:0002028)2.55988852
69IgA deficiency (HP:0002720)2.53915778
70Aplastic anemia (HP:0001915)2.47375004
71Recurrent skin infections (HP:0001581)2.46057841
72Type 2 muscle fiber atrophy (HP:0003554)2.44501340
73Severe visual impairment (HP:0001141)2.41683190
74Hepatocellular necrosis (HP:0001404)2.40601797
75Porencephaly (HP:0002132)2.40327986
76Bile duct proliferation (HP:0001408)2.38396225
77Abnormal biliary tract physiology (HP:0012439)2.38396225
78Purpura (HP:0000979)2.33899764
79Poikilocytosis (HP:0004447)2.33458343
80Stomach cancer (HP:0012126)2.31427316
81Hepatic necrosis (HP:0002605)2.29999401
82Gingival bleeding (HP:0000225)2.29194006
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.28263175
84Inappropriate behavior (HP:0000719)2.28054073
85IgG deficiency (HP:0004315)2.27785882
86Muscle fiber atrophy (HP:0100295)2.27246322
87Prostate neoplasm (HP:0100787)2.26734752
88Thyroid-stimulating hormone excess (HP:0002925)2.26248779
89Mitochondrial inheritance (HP:0001427)2.25345439
90True hermaphroditism (HP:0010459)2.25288908
91B lymphocytopenia (HP:0010976)2.25153835
92Abnormality of B cell number (HP:0010975)2.25153835
93Striae distensae (HP:0001065)2.24352586
94Nephronophthisis (HP:0000090)2.23961127
95Arterial tortuosity (HP:0005116)2.23322572
96Neoplasm of the lung (HP:0100526)2.22481884
97Lymphopenia (HP:0001888)2.22464768
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21134382
99Abnormality of midbrain morphology (HP:0002418)2.20685868
100Molar tooth sign on MRI (HP:0002419)2.20685868
101Meningitis (HP:0001287)2.20661147
102Nonprogressive disorder (HP:0003680)2.20148747
103Abnormality of transition element cation homeostasis (HP:0011030)2.19563330
104Decreased central vision (HP:0007663)2.18534571
105Failure to thrive in infancy (HP:0001531)2.16464302
106Impaired platelet aggregation (HP:0003540)2.15303968
107Abnormal platelet function (HP:0011869)2.15303968
108Abnormality of T cells (HP:0002843)2.14188274
109Abnormality of the renal medulla (HP:0100957)2.14144550
110Cutis marmorata (HP:0000965)2.13716076
111Increased CSF lactate (HP:0002490)2.13073445
112Paralysis (HP:0003470)2.11501653
113Vascular tortuosity (HP:0004948)2.11070188
114Abnormality of cells of the lymphoid lineage (HP:0012140)2.10331089
115Myelodysplasia (HP:0002863)2.10220613
116Emphysema (HP:0002097)2.09129749
117Abnormality of the heme biosynthetic pathway (HP:0010472)2.08370615
118Increased cerebral lipofuscin (HP:0011813)2.08106441
119Medial flaring of the eyebrow (HP:0010747)2.06337307
120Subacute progressive viral hepatitis (HP:0006572)2.06210006
121Mediastinal lymphadenopathy (HP:0100721)2.06182540
122Agitation (HP:0000713)2.05775770
123Cerebral aneurysm (HP:0004944)2.05628693
124Abnormality of T cell physiology (HP:0011840)2.05535040
125Weak cry (HP:0001612)2.05457410
126Central scotoma (HP:0000603)2.04995290
127Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04938812
128Neoplasm of the respiratory system (HP:0100606)2.04745864
129Blepharitis (HP:0000498)2.03719905
130Spondylolisthesis (HP:0003302)2.02849062
131Acute myeloid leukemia (HP:0004808)2.02236651
132Gaze-evoked nystagmus (HP:0000640)2.02074417
133Hepatitis (HP:0012115)2.01332719
134Tapered finger (HP:0001182)2.00506962
135Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00200079
136Abnormal protein N-linked glycosylation (HP:0012347)2.00200079
137Abnormal protein glycosylation (HP:0012346)2.00200079
138Abnormal glycosylation (HP:0012345)2.00200079
139Exercise-induced myalgia (HP:0003738)1.99915761
140Aortic aneurysm (HP:0004942)1.98756164
141Abnormality of T cell number (HP:0011839)1.98476817
142Abnormality of male internal genitalia (HP:0000022)1.96934370
143Bronchitis (HP:0012387)1.96644923
144Vasculitis (HP:0002633)1.94937839
145Apathy (HP:0000741)1.94521111
146Acute encephalopathy (HP:0006846)1.94007364
147T lymphocytopenia (HP:0005403)1.93088805
148Polyphagia (HP:0002591)1.92629134
149Spontaneous hematomas (HP:0007420)1.92462971
150Osteomyelitis (HP:0002754)1.92068536
151Abnormality of the intervertebral disk (HP:0005108)1.91654081
152Esophageal varix (HP:0002040)1.90900577
153Prominent nose (HP:0000448)1.90833530
154Increased serum lactate (HP:0002151)1.90147703
155Abnormal mitochondria in muscle tissue (HP:0008316)1.88848066
156Hematochezia (HP:0002573)1.88637653
157Acute necrotizing encephalopathy (HP:0006965)1.87755620
158Amyotrophic lateral sclerosis (HP:0007354)1.87666581
159Hypoplasia of the iris (HP:0007676)1.87458784
160Leukocytosis (HP:0001974)1.83890661
161Widely spaced teeth (HP:0000687)1.82818169
162Recurrent pneumonia (HP:0006532)1.81748931
163Abnormality of iron homeostasis (HP:0011031)1.81434846
164Tubulointerstitial abnormality (HP:0001969)1.80489880
165Congenital hepatic fibrosis (HP:0002612)1.79494290
166Hypoplasia of the fovea (HP:0007750)1.79158336
167Aplasia/Hypoplasia of the fovea (HP:0008060)1.79158336
168Bicuspid aortic valve (HP:0001647)1.77165474
169Abnormal pupillary function (HP:0007686)1.77058243
170Reticulocytosis (HP:0001923)1.76918174
171Clubbing of toes (HP:0100760)1.76470831
172Cerebral palsy (HP:0100021)1.75905360
173Neoplasm of the adrenal cortex (HP:0100641)1.75687430
174Diminished motivation (HP:0000745)1.75539008
175Progressive macrocephaly (HP:0004481)1.75482641
176Progressive microcephaly (HP:0000253)1.74717754
177Optic disc pallor (HP:0000543)1.74670558
178Polydipsia (HP:0001959)1.73043976
179Abnormal drinking behavior (HP:0030082)1.73043976
180Colon cancer (HP:0003003)1.72623057
181Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72532489
182Abnormality of alanine metabolism (HP:0010916)1.72532489
183Hyperalaninemia (HP:0003348)1.72532489
184Cystic liver disease (HP:0006706)1.71180224
185Thrombocytosis (HP:0001894)1.69113164
186Albinism (HP:0001022)1.66599457
187Dysautonomia (HP:0002459)1.66583118
188Type I transferrin isoform profile (HP:0003642)1.65431033
189Amelogenesis imperfecta (HP:0000705)1.65066312
190Tinnitus (HP:0000360)1.64227272
191Hyperthyroidism (HP:0000836)1.63093224
192Ketosis (HP:0001946)1.62299051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR27.22514907
2DMPK3.86323302
3MAP4K13.71788664
4BCKDK3.02213377
5FRK3.00982309
6SCYL22.81304416
7ITK2.66924334
8STK102.63331765
9TGFBR22.42896637
10IKBKB2.35025741
11JAK32.25636965
12TYK22.15101170
13ZAK2.07452383
14ADRBK22.03688167
15MAPK151.91004956
16MAP4K21.82217599
17MAP3K141.80783738
18MAP3K131.79768078
19FGFR41.79656238
20EIF2AK31.68878347
21ZAP701.68810105
22IKBKE1.65419878
23FGFR31.64694222
24MAPK131.63026747
25VRK21.59965653
26EIF2AK11.59441446
27CCNB11.57101775
28GRK61.55410123
29TBK11.54528072
30GSK3A1.53660799
31WNK31.51193198
32TAOK11.49406216
33CDC71.48554475
34TNK21.44699563
35CDK81.43908462
36JAK11.43833287
37TXK1.41509660
38LRRK21.40752972
39VRK11.38223423
40CDK91.32964794
41EPHB11.32811878
42KDR1.31723182
43MAP3K111.30973270
44MARK21.29369284
45PINK11.27278803
46CHUK1.22923850
47TIE11.22665609
48DAPK21.21337640
49NUAK11.20643887
50BLK1.19780873
51EPHA31.12367932
52MAP3K51.11470175
53PTK61.11429633
54MAPKAPK31.11380322
55TEC1.11051547
56NLK1.10686431
57SYK1.09644806
58CSK1.07036283
59MUSK1.07000296
60TSSK61.06479441
61CSNK1G31.05871222
62IRAK41.05137989
63IRAK11.04099307
64PIM21.02380120
65TRIB31.02169106
66MAP3K71.01058737
67INSRR0.98771282
68KIT0.98695156
69HIPK20.97553197
70BMPR1B0.97022999
71CSF1R0.95707794
72MAPKAPK50.95228027
73CSNK1G20.92019594
74MAP3K40.90736355
75ERN10.90293014
76HCK0.90142659
77PAK40.89623065
78PRKCQ0.89438479
79ALK0.87808180
80FLT30.87793121
81GRK10.86741465
82RIPK40.85924587
83LCK0.84264259
84PRKCH0.83585096
85RPS6KB20.83527454
86RIPK10.83522259
87PIK3CA0.83511211
88RPS6KA50.83160702
89BTK0.82365302
90RPS6KA40.80707633
91NME20.79444037
92TRPM70.78346693
93CHEK20.78078399
94CSNK1G10.77945425
95SGK30.77350737
96EEF2K0.76116730
97DAPK10.74895586
98MARK30.73867551
99PIK3CG0.73171655
100ATR0.73030322
101PRKD20.71229694
102MAP2K30.70755539
103LATS20.70344807
104CSNK1A1L0.68401349
105CDK60.66527877
106PIM10.62380819
107CLK10.62320845
108PDGFRB0.62070175
109ADRBK10.61628934
110TAOK30.60499428
111CAMK1G0.60423085
112MAP2K70.60308341
113FES0.59570385
114SIK20.57366097
115MKNK10.56856291
116PRKD10.56182961
117PLK20.56088379
118MELK0.54852683
119PLK40.53851218
120EPHB20.52466086
121JAK20.52454121
122CDK120.49511761
123ABL20.49238121
124WNK10.48455592
125TGFBR10.48124227
126RAF10.47798827
127PTK2B0.47251543
128RET0.46820367
129PDK10.46402250
130STK240.46086352
131MATK0.44730349
132GRK50.43190482
133MAPK30.42912725
134ILK0.42280622
135DYRK20.41748212
136ATM0.41693809
137SRPK10.41534385
138PRKAA10.41322442
139ERBB30.41104469
140CDK30.40956998
141RPS6KA60.40526867
142MAPK70.39922696
143GRK70.39785091
144PKN10.39377602
145MAP3K90.38621225
146ABL10.38348680
147MTOR0.38258368
148PRKCE0.37494740
149MAPK120.36713219
150PRKG20.35562453
151EGFR0.35336205
152OXSR10.34862005
153IRAK20.34669094
154STK40.34183685
155LYN0.33675537
156MAPK110.33088726
157DYRK1A0.32665214
158MST40.32291227
159CSNK2A10.31817648
160PRKAA20.31618407
161CDK40.31362640
162DYRK30.30777340
163IGF1R0.30500041
164STK30.30304521
165BRSK20.30233610
166MAPK90.29723739

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.47514380
2Base excision repair_Homo sapiens_hsa034103.26455232
3Primary immunodeficiency_Homo sapiens_hsa053403.15401711
4Homologous recombination_Homo sapiens_hsa034403.14870265
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.09818422
6B cell receptor signaling pathway_Homo sapiens_hsa046622.81251992
7T cell receptor signaling pathway_Homo sapiens_hsa046602.78773871
8Mismatch repair_Homo sapiens_hsa034302.64941538
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.60881066
10Osteoclast differentiation_Homo sapiens_hsa043802.44773054
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.35649388
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.26421131
13DNA replication_Homo sapiens_hsa030302.21711326
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16076369
15Pancreatic cancer_Homo sapiens_hsa052122.14204713
16Antigen processing and presentation_Homo sapiens_hsa046122.06704293
17Leishmaniasis_Homo sapiens_hsa051402.02450351
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.96014510
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90671377
20Measles_Homo sapiens_hsa051621.89357963
21Butanoate metabolism_Homo sapiens_hsa006501.85494501
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85460233
23Olfactory transduction_Homo sapiens_hsa047401.83322619
24Nitrogen metabolism_Homo sapiens_hsa009101.76936794
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76852778
26TNF signaling pathway_Homo sapiens_hsa046681.75439383
27Linoleic acid metabolism_Homo sapiens_hsa005911.72012150
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71090082
29Toxoplasmosis_Homo sapiens_hsa051451.69540204
30Phototransduction_Homo sapiens_hsa047441.69409034
31Arachidonic acid metabolism_Homo sapiens_hsa005901.68923163
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68612020
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.67649823
34Ether lipid metabolism_Homo sapiens_hsa005651.66414087
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.65971240
36Pyrimidine metabolism_Homo sapiens_hsa002401.57012502
37Asthma_Homo sapiens_hsa053101.56781206
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.54846439
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54107823
40Platelet activation_Homo sapiens_hsa046111.53266296
41Hematopoietic cell lineage_Homo sapiens_hsa046401.51213860
42Apoptosis_Homo sapiens_hsa042101.51030656
43Acute myeloid leukemia_Homo sapiens_hsa052211.46214738
44Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45135709
45Propanoate metabolism_Homo sapiens_hsa006401.41838889
46Nucleotide excision repair_Homo sapiens_hsa034201.40965420
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39063493
48Chemokine signaling pathway_Homo sapiens_hsa040621.38777216
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36976981
50Chronic myeloid leukemia_Homo sapiens_hsa052201.36403555
51One carbon pool by folate_Homo sapiens_hsa006701.36176690
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35561769
53Small cell lung cancer_Homo sapiens_hsa052221.33460002
54Peroxisome_Homo sapiens_hsa041461.32786840
55Purine metabolism_Homo sapiens_hsa002301.32656150
56Spliceosome_Homo sapiens_hsa030401.27592683
57Herpes simplex infection_Homo sapiens_hsa051681.26665581
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25674735
59Hepatitis B_Homo sapiens_hsa051611.25645004
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23222064
61RNA degradation_Homo sapiens_hsa030181.22529298
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16249059
63Influenza A_Homo sapiens_hsa051641.14271535
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14157961
65NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13957475
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.12001166
67Basal transcription factors_Homo sapiens_hsa030221.11371706
68Neurotrophin signaling pathway_Homo sapiens_hsa047221.11306501
69Fatty acid elongation_Homo sapiens_hsa000621.10917003
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10415702
71Thyroid cancer_Homo sapiens_hsa052161.10078798
72Inositol phosphate metabolism_Homo sapiens_hsa005621.07982137
73Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05442317
74Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05439501
75Viral carcinogenesis_Homo sapiens_hsa052031.03376442
76Taste transduction_Homo sapiens_hsa047421.03231251
77Viral myocarditis_Homo sapiens_hsa054161.03007322
78Non-small cell lung cancer_Homo sapiens_hsa052231.02654440
79Hepatitis C_Homo sapiens_hsa051601.02091262
80Selenocompound metabolism_Homo sapiens_hsa004501.00421569
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99138673
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98378828
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97521391
84Allograft rejection_Homo sapiens_hsa053300.96576977
85MAPK signaling pathway_Homo sapiens_hsa040100.96071284
86Prolactin signaling pathway_Homo sapiens_hsa049170.95278103
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94748900
88Parkinsons disease_Homo sapiens_hsa050120.94698737
89Colorectal cancer_Homo sapiens_hsa052100.94087863
90RNA polymerase_Homo sapiens_hsa030200.93580846
91Shigellosis_Homo sapiens_hsa051310.91660190
92Notch signaling pathway_Homo sapiens_hsa043300.91286483
93ABC transporters_Homo sapiens_hsa020100.90311595
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90173386
95Proteoglycans in cancer_Homo sapiens_hsa052050.88422909
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88269504
97VEGF signaling pathway_Homo sapiens_hsa043700.87795049
98Graft-versus-host disease_Homo sapiens_hsa053320.87297545
99Tuberculosis_Homo sapiens_hsa051520.86532336
100MicroRNAs in cancer_Homo sapiens_hsa052060.86363173
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84526164
102Type I diabetes mellitus_Homo sapiens_hsa049400.84071560
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83308125
104African trypanosomiasis_Homo sapiens_hsa051430.80790965
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.77802678
106Calcium signaling pathway_Homo sapiens_hsa040200.76392266
107Fatty acid biosynthesis_Homo sapiens_hsa000610.75732187
108Focal adhesion_Homo sapiens_hsa045100.75723054
109Pertussis_Homo sapiens_hsa051330.75174099
110Oxidative phosphorylation_Homo sapiens_hsa001900.73271766
111RNA transport_Homo sapiens_hsa030130.72822606
112HTLV-I infection_Homo sapiens_hsa051660.71967533
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71125812
114Regulation of autophagy_Homo sapiens_hsa041400.70661609
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70598989
116Insulin resistance_Homo sapiens_hsa049310.70329252
117Autoimmune thyroid disease_Homo sapiens_hsa053200.70210188
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69440431
119FoxO signaling pathway_Homo sapiens_hsa040680.69213715
120Renal cell carcinoma_Homo sapiens_hsa052110.67701905
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67401929
122Endometrial cancer_Homo sapiens_hsa052130.67086329
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66755113
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.66638023
125Legionellosis_Homo sapiens_hsa051340.65703461
126Adherens junction_Homo sapiens_hsa045200.64674634
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64439267
128Metabolic pathways_Homo sapiens_hsa011000.62805313
129Epstein-Barr virus infection_Homo sapiens_hsa051690.62071968
130Glutathione metabolism_Homo sapiens_hsa004800.60904166
131Dorso-ventral axis formation_Homo sapiens_hsa043200.60559889
132Salivary secretion_Homo sapiens_hsa049700.59914347
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.59122937
134Rap1 signaling pathway_Homo sapiens_hsa040150.59022593
135Pathways in cancer_Homo sapiens_hsa052000.58922785
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58430080
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58294271
138Prostate cancer_Homo sapiens_hsa052150.56407152
139Serotonergic synapse_Homo sapiens_hsa047260.54707519
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53709001
141Ovarian steroidogenesis_Homo sapiens_hsa049130.53675219
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53481232
143Estrogen signaling pathway_Homo sapiens_hsa049150.53358884
144TGF-beta signaling pathway_Homo sapiens_hsa043500.53119690
145Choline metabolism in cancer_Homo sapiens_hsa052310.53039392
146Tryptophan metabolism_Homo sapiens_hsa003800.52296358
147Staphylococcus aureus infection_Homo sapiens_hsa051500.51826231
148Amoebiasis_Homo sapiens_hsa051460.51612582
149Renin secretion_Homo sapiens_hsa049240.50951387
150Chemical carcinogenesis_Homo sapiens_hsa052040.50549320
151Lysine degradation_Homo sapiens_hsa003100.48841257
152Protein export_Homo sapiens_hsa030600.47450330
153Gastric acid secretion_Homo sapiens_hsa049710.47080403
154Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46540439
155Drug metabolism - other enzymes_Homo sapiens_hsa009830.45595818
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45086309
157mTOR signaling pathway_Homo sapiens_hsa041500.45020102
158Non-homologous end-joining_Homo sapiens_hsa034500.44644856
159HIF-1 signaling pathway_Homo sapiens_hsa040660.43315315
160ErbB signaling pathway_Homo sapiens_hsa040120.42851117
161Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42559170
162Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42508420
163Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41016002
164p53 signaling pathway_Homo sapiens_hsa041150.40973173
165Fatty acid metabolism_Homo sapiens_hsa012120.40813324
166Long-term depression_Homo sapiens_hsa047300.40474059
167Circadian entrainment_Homo sapiens_hsa047130.38429474
168Maturity onset diabetes of the young_Homo sapiens_hsa049500.36054089
169Caffeine metabolism_Homo sapiens_hsa002320.34632023
170Primary bile acid biosynthesis_Homo sapiens_hsa001200.34013564
171Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33547264
172Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33426768
173Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32814230
174Nicotine addiction_Homo sapiens_hsa050330.32521600
175Rheumatoid arthritis_Homo sapiens_hsa053230.32078866
176Sphingolipid metabolism_Homo sapiens_hsa006000.30857127
177Glycerolipid metabolism_Homo sapiens_hsa005610.30503616
178Systemic lupus erythematosus_Homo sapiens_hsa053220.28306508

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