STAG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the cohesin complex, which regulates the separation of sister chromatids during cell division. Targeted inactivation of this gene results in chromatid cohesion defects and aneuploidy, suggesting that genetic disruption of cohesin is a cause of aneuploidy in human cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane repolarization during cardiac muscle cell action potential (GO:0086013)8.22914913
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)7.63685520
3membrane repolarization during action potential (GO:0086011)7.54084396
4behavioral response to nicotine (GO:0035095)6.82884058
5cell proliferation in forebrain (GO:0021846)6.70214578
6membrane repolarization (GO:0086009)5.40159144
7cerebellar Purkinje cell differentiation (GO:0021702)5.22452382
8vitamin A metabolic process (GO:0006776)5.18244785
9parturition (GO:0007567)4.93953896
10regulation of membrane repolarization (GO:0060306)4.66224018
11mitotic sister chromatid cohesion (GO:0007064)4.42331136
12nuclear pore complex assembly (GO:0051292)4.38169471
13cellular anion homeostasis (GO:0030002)4.31181834
14DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.28947110
15cellular response to electrical stimulus (GO:0071257)4.23814317
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23485406
17negative regulation of response to food (GO:0032096)4.19894371
18negative regulation of appetite (GO:0032099)4.19894371
19negative regulation of transcription regulatory region DNA binding (GO:2000678)4.15835997
20cellular potassium ion homeostasis (GO:0030007)4.13612631
21positive regulation of gamma-delta T cell activation (GO:0046645)4.12174170
22positive regulation of synapse maturation (GO:0090129)4.09695948
23nuclear pore organization (GO:0006999)4.04055153
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.95822212
25forebrain neuron differentiation (GO:0021879)3.89404701
26interkinetic nuclear migration (GO:0022027)3.89252883
27DNA damage response, signal transduction resulting in transcription (GO:0042772)3.85705366
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85704498
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85704498
30regulation of potassium ion transmembrane transport (GO:1901379)3.83787736
31dentate gyrus development (GO:0021542)3.83462321
32mitotic chromosome condensation (GO:0007076)3.83374863
33magnesium ion transport (GO:0015693)3.78029106
34cell differentiation in hindbrain (GO:0021533)3.77930760
35opsonization (GO:0008228)3.77268593
36spinal cord association neuron differentiation (GO:0021527)3.74287639
37tooth mineralization (GO:0034505)3.70845806
38regulation of synapse maturation (GO:0090128)3.58735224
39positive regulation of potassium ion transmembrane transport (GO:1901381)3.56769293
40regulation of gamma-delta T cell differentiation (GO:0045586)3.54743505
41cardiovascular system development (GO:0072358)3.52338253
42cellular response to exogenous dsRNA (GO:0071360)3.52274630
43snRNA transcription (GO:0009301)3.51551539
44embryonic retina morphogenesis in camera-type eye (GO:0060059)3.51389749
45monoubiquitinated protein deubiquitination (GO:0035520)3.46711731
46dendritic spine morphogenesis (GO:0060997)3.46074719
47regulation of skeletal muscle contraction (GO:0014819)3.45864821
48antigen processing and presentation of endogenous antigen (GO:0019883)3.45849196
49regulation of heart rate by cardiac conduction (GO:0086091)3.41175943
50pore complex assembly (GO:0046931)3.41010551
51ovulation cycle (GO:0042698)3.37807327
52negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.37389732
53head development (GO:0060322)3.36416478
54protein localization to kinetochore (GO:0034501)3.29770900
55regulation of RNA export from nucleus (GO:0046831)3.27424520
56regulation of female receptivity (GO:0045924)3.25359240
57regulation of spindle organization (GO:0090224)3.24537700
58DNA unwinding involved in DNA replication (GO:0006268)3.24207226
59serotonin metabolic process (GO:0042428)3.23474960
60regulation of gamma-delta T cell activation (GO:0046643)3.23042238
61fat-soluble vitamin catabolic process (GO:0042363)3.22944566
62vitamin catabolic process (GO:0009111)3.22944566
63retinal ganglion cell axon guidance (GO:0031290)3.22520667
64sister chromatid segregation (GO:0000819)3.21695084
65negative regulation of neurotransmitter secretion (GO:0046929)3.20567732
66positive regulation of cardiac muscle cell differentiation (GO:2000727)3.20186303
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18189941
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18189941
69positive regulation of mitotic sister chromatid separation (GO:1901970)3.18189941
70spinal cord development (GO:0021510)3.17066275
71regulation of potassium ion transmembrane transporter activity (GO:1901016)3.16558616
72dosage compensation (GO:0007549)3.08528457
73transmission of nerve impulse (GO:0019226)3.07343789
74negative regulation of axon extension involved in axon guidance (GO:0048843)3.07230134
75negative regulation of potassium ion transmembrane transport (GO:1901380)3.04573804
76protein polyglutamylation (GO:0018095)3.04321785
77definitive hemopoiesis (GO:0060216)3.03807319
78regulation of mitotic spindle organization (GO:0060236)3.03570326
79DNA topological change (GO:0006265)3.03094802
80positive regulation of protein homodimerization activity (GO:0090073)3.02444027
81gamma-aminobutyric acid transport (GO:0015812)3.02224551
82positive regulation of chromosome segregation (GO:0051984)2.99852386
83multicellular organismal signaling (GO:0035637)2.98013998
84activated T cell proliferation (GO:0050798)2.95562478
85genetic imprinting (GO:0071514)2.94921743
86mesenchymal cell differentiation involved in renal system development (GO:2001012)2.94044823
87mesenchymal cell differentiation involved in kidney development (GO:0072161)2.94044823
88regulation of mesoderm development (GO:2000380)2.93638848
89negative regulation of systemic arterial blood pressure (GO:0003085)2.92439519
90hepatocyte apoptotic process (GO:0097284)2.91826012
91phosphate ion homeostasis (GO:0055062)2.91391536
92trivalent inorganic anion homeostasis (GO:0072506)2.91391536
93histone H3-K36 demethylation (GO:0070544)2.90795904
94regulation of histone H3-K9 methylation (GO:0051570)2.90122787
95regulation of sister chromatid cohesion (GO:0007063)2.89019543
96olfactory bulb development (GO:0021772)2.88903012
97response to electrical stimulus (GO:0051602)2.87184962
98positive regulation of fatty acid beta-oxidation (GO:0032000)2.85195075
99epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.84849736
100negative regulation of histone methylation (GO:0031061)2.84838730
101positive regulation of histone deacetylation (GO:0031065)2.84743870
102positive thymic T cell selection (GO:0045059)2.83853489
103regulation of chromatin binding (GO:0035561)2.82302234
104regulation of glomerulus development (GO:0090192)2.81329693
105cytoplasmic mRNA processing body assembly (GO:0033962)2.81302606
106membrane depolarization during action potential (GO:0086010)2.80068061
107protein localization to chromosome, centromeric region (GO:0071459)2.79546479
108cell differentiation in spinal cord (GO:0021515)2.78919730
109endoderm formation (GO:0001706)2.78640888
110regulation of potassium ion transport (GO:0043266)2.77120058
111regulation of transcription regulatory region DNA binding (GO:2000677)2.76709130
112glomerulus development (GO:0032835)2.76100684
113DNA duplex unwinding (GO:0032508)2.76038729
114positive regulation of T cell apoptotic process (GO:0070234)2.75820433
115pyrimidine nucleobase catabolic process (GO:0006208)2.75027633
116urogenital system development (GO:0001655)2.74656204
117DNA geometric change (GO:0032392)2.73510572
118cerebellum development (GO:0021549)2.73466776
119positive regulation of B cell differentiation (GO:0045579)2.73088350
120regulation of response to food (GO:0032095)2.72767522
121positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.71993358
122sulfation (GO:0051923)2.71101875
123cardiac conduction (GO:0061337)2.70339730
124growth hormone receptor signaling pathway (GO:0060396)2.69787007
125regulation of hydrogen peroxide metabolic process (GO:0010310)2.68484712
126nucleus localization (GO:0051647)2.66760446
127histone-serine phosphorylation (GO:0035404)2.66566707
128primary amino compound metabolic process (GO:1901160)2.64304989
129mRNA stabilization (GO:0048255)2.63637994
130RNA stabilization (GO:0043489)2.63637994
131cellular response to ATP (GO:0071318)2.63459060
132regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.63147671
133potassium ion import (GO:0010107)2.63032801
134outer ear morphogenesis (GO:0042473)2.62975440
135camera-type eye morphogenesis (GO:0048593)2.62621438
136regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62437094
137chromatin assembly (GO:0031497)2.62331126
138histone mRNA catabolic process (GO:0071044)2.61600452
139positive regulation of organelle assembly (GO:1902117)2.61393142
140regulation of nucleobase-containing compound transport (GO:0032239)2.61130521
141mitotic nuclear envelope disassembly (GO:0007077)2.59928236
142telencephalon development (GO:0021537)2.58793913
143translesion synthesis (GO:0019985)2.58705784
144negative T cell selection (GO:0043383)2.58043193
145auditory receptor cell differentiation (GO:0042491)2.57744537
146neural precursor cell proliferation (GO:0061351)2.56895353
147hypothalamus development (GO:0021854)2.56366644
148regulation of protein heterodimerization activity (GO:0043497)2.55743141
149establishment of protein localization to mitochondrial membrane (GO:0090151)2.55726246
150female mating behavior (GO:0060180)2.54858359
151potassium ion homeostasis (GO:0055075)2.53466632
152germ cell migration (GO:0008354)2.51151329
153alternative mRNA splicing, via spliceosome (GO:0000380)2.50987784
154JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49569206
155membrane disassembly (GO:0030397)2.49375018
156nuclear envelope disassembly (GO:0051081)2.49375018
157glucocorticoid receptor signaling pathway (GO:0042921)2.49302844
158negative thymic T cell selection (GO:0045060)2.46274572
159histone H2A monoubiquitination (GO:0035518)2.42910970
160histone H3-K9 demethylation (GO:0033169)2.40214890
161corticosteroid receptor signaling pathway (GO:0031958)2.35654518
162negative regulation of phagocytosis (GO:0050765)2.34935971
163negative regulation of fibroblast apoptotic process (GO:2000270)2.33780655
164negative regulation of B cell proliferation (GO:0030889)2.32804132
165mitotic sister chromatid segregation (GO:0000070)2.32421223
166cellular response to growth hormone stimulus (GO:0071378)2.31796542
167chromosome condensation (GO:0030261)2.31553645
168thymic T cell selection (GO:0045061)2.30434211
169positive T cell selection (GO:0043368)2.28228482
170chromatin assembly or disassembly (GO:0006333)2.28168981
171positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.27623300
172NLS-bearing protein import into nucleus (GO:0006607)2.26586434
173DNA conformation change (GO:0071103)2.26534825
174kinetochore organization (GO:0051383)2.26454969
175histone lysine demethylation (GO:0070076)2.25254471
176regulation of B cell differentiation (GO:0045577)2.23825377
177protein localization to chromosome (GO:0034502)2.23610945
178mitotic metaphase plate congression (GO:0007080)2.23173587
179response to UV-C (GO:0010225)2.21901662
180histone demethylation (GO:0016577)2.20126222
181positive regulation of protein import into nucleus, translocation (GO:0033160)2.18787530
182metaphase plate congression (GO:0051310)2.17567109
183embryonic process involved in female pregnancy (GO:0060136)2.16679450
184T cell selection (GO:0045058)2.16362272
185regulation of mRNA stability (GO:0043488)2.16187080
186nuclear envelope organization (GO:0006998)2.16107812
187antigen processing and presentation via MHC class Ib (GO:0002475)2.15562899
188regulation of B cell receptor signaling pathway (GO:0050855)2.14979330
189epithelial cell differentiation involved in prostate gland development (GO:0060742)2.14437738
190regulation of interleukin-12 biosynthetic process (GO:0045075)2.14071876
191positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.14060625
192embryonic camera-type eye morphogenesis (GO:0048596)2.13761540
193peptidyl-lysine dimethylation (GO:0018027)2.13742681
194natural killer cell differentiation (GO:0001779)2.13066497
195positive regulation of protein deacetylation (GO:0090312)2.12063403
196regulation of histone methylation (GO:0031060)2.09801560
197meiotic chromosome segregation (GO:0045132)2.08060914
198morphogenesis of an endothelium (GO:0003159)2.07478259
199endothelial tube morphogenesis (GO:0061154)2.07478259
200V(D)J recombination (GO:0033151)2.07196928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.45108434
2EZH2_22144423_ChIP-Seq_EOC_Human7.88055487
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.16995830
4FOXM1_23109430_ChIP-Seq_U2OS_Human5.03601364
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.16522962
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.81954364
7* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.23662465
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.16002190
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08879943
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.87960811
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82051740
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.78349377
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.78240803
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.74363558
15* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.60262407
16MYC_22102868_ChIP-Seq_BL_Human2.59484317
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.51975440
18GATA1_22025678_ChIP-Seq_K562_Human2.46079511
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45467022
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.45088262
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45079053
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39024212
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.36277669
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.34457400
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28215194
26REST_21632747_ChIP-Seq_MESCs_Mouse2.24711770
27RNF2_27304074_Chip-Seq_NSC_Mouse2.19800531
28GATA1_26923725_Chip-Seq_HPCs_Mouse2.17396529
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.14091502
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.13006956
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09838493
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.09312420
33SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03821527
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.03356463
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03026697
36E2F1_21310950_ChIP-Seq_MCF-7_Human2.01817904
37EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01054961
38RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01054961
39AR_21909140_ChIP-Seq_LNCAP_Human1.99038156
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.98220574
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94660016
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93381221
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93101799
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.92558142
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91993327
46* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86039657
47* MYB_26560356_Chip-Seq_TH2_Human1.84859997
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81157993
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78452803
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75901525
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74066637
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72427828
53* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70747982
54* MYB_26560356_Chip-Seq_TH1_Human1.69414749
55SCL_19346495_ChIP-Seq_HPC-7_Human1.69317237
56EWS_26573619_Chip-Seq_HEK293_Human1.68076814
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67006215
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.65044469
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.64721869
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63260019
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62732422
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62732422
63MAF_26560356_Chip-Seq_TH1_Human1.62448515
64* IRF8_27001747_Chip-Seq_BMDM_Mouse1.62366738
65SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.62288470
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58343405
67FUS_26573619_Chip-Seq_HEK293_Human1.57965172
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57250504
69* IRF1_19129219_ChIP-ChIP_H3396_Human1.57242179
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56654940
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56585274
72VDR_21846776_ChIP-Seq_THP-1_Human1.55745495
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54683076
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54095207
75CLOCK_20551151_ChIP-Seq_293T_Human1.52522574
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52106472
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.50724564
78RUNX_20019798_ChIP-Seq_JUKART_Human1.50656656
79UTX_26944678_Chip-Seq_JUKART_Human1.50291767
80* TCF7_22412390_ChIP-Seq_EML_Mouse1.49305223
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47574256
82IGF1R_20145208_ChIP-Seq_DFB_Human1.44034658
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.42698667
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.41306523
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40208015
86GBX2_23144817_ChIP-Seq_PC3_Human1.39686820
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39272663
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38423603
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37436049
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.37290208
91IRF8_21731497_ChIP-ChIP_J774_Mouse1.36809462
92VDR_22108803_ChIP-Seq_LS180_Human1.36678497
93TAF15_26573619_Chip-Seq_HEK293_Human1.35129299
94STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34047443
95ELK1_19687146_ChIP-ChIP_HELA_Human1.33759684
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32030328
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.30124125
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29767077
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27835898
100MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27705648
101GATA3_27048872_Chip-Seq_THYMUS_Human1.27619244
102* SPI1_23547873_ChIP-Seq_NB4_Human1.27141455
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.26491294
104TP63_19390658_ChIP-ChIP_HaCaT_Human1.25853383
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24676936
106* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22842037
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.21228794
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20776820
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20271354
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.19512649
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18776643
112VDR_24763502_ChIP-Seq_THP-1_Human1.17232553
113* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16762497
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16725290
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15384042
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14865952
117MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14755526
118PU_27001747_Chip-Seq_BMDM_Mouse1.14644667
119STAT3_23295773_ChIP-Seq_U87_Human1.14346780
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13868908
121ZNF274_21170338_ChIP-Seq_K562_Hela1.13084275
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12917105
123POU3F2_20337985_ChIP-ChIP_501MEL_Human1.12542975
124GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12464343
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12163088
126TCF4_23295773_ChIP-Seq_U87_Human1.12086174
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11467900
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10140998
129SMAD4_21799915_ChIP-Seq_A2780_Human1.09209066
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08469383
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.07848115
132* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06514569
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05917949
134* P300_19829295_ChIP-Seq_ESCs_Human1.05860318
135NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05699856
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05352006
137ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05124604
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04721026
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04379753
140CBP_20019798_ChIP-Seq_JUKART_Human1.04379753
141ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04029028
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03916361
143SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02876009
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02008026
145* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00905914
146SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00194238
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00194238
148JUN_21703547_ChIP-Seq_K562_Human1.00029448
149NCOR1_26117541_ChIP-Seq_K562_Human0.98822271
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.98407801
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98337385
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98061004
153KDM2B_26808549_Chip-Seq_REH_Human0.97396888
154* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97394395
155GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97137786
156TFEB_21752829_ChIP-Seq_HELA_Human0.96490575
157KDM5A_27292631_Chip-Seq_BREAST_Human0.96116284
158MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95966461
159* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95962431
160KDM2B_26808549_Chip-Seq_DND41_Human0.95700783
161SOX2_16153702_ChIP-ChIP_HESCs_Human0.95565287
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95552445
163CHD1_26751641_Chip-Seq_LNCaP_Human0.95420034
164EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95133113
165CIITA_25753668_ChIP-Seq_RAJI_Human0.94552921
166LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94451290
167BRD4_25478319_ChIP-Seq_HGPS_Human0.93813553
168AR_19668381_ChIP-Seq_PC3_Human0.93466026
169PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93373782
170GF1_26923725_Chip-Seq_HPCs_Mouse0.93352164
171AR_21572438_ChIP-Seq_LNCaP_Human0.92637931
172SMAD3_21741376_ChIP-Seq_EPCs_Human0.91938050
173SOX9_26525672_Chip-Seq_HEART_Mouse0.91881570
174NANOG_16153702_ChIP-ChIP_HESCs_Human0.91445971
175RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91229283
176SMAD3_21741376_ChIP-Seq_ESCs_Human0.90704272
177Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90420513
178PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90351121
179FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89635735
180GATA6_25053715_ChIP-Seq_YYC3_Human0.88795806
181E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87150860
182MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86968719
183EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.85915409
184CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85767043
185SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85558172
186VDR_23849224_ChIP-Seq_CD4+_Human0.85440893
187TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84898250
188SPI1_23127762_ChIP-Seq_K562_Human0.84833115
189KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83689739
190RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82724391
191MYC_18555785_ChIP-Seq_MESCs_Mouse0.82685123
192SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82495797
193GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81565629
194NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81496595

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.89550920
2MP0003787_abnormal_imprinting3.38884074
3MP0003646_muscle_fatigue3.34856537
4MP0002160_abnormal_reproductive_system3.31064037
5MP0002166_altered_tumor_susceptibility2.92430800
6MP0001485_abnormal_pinna_reflex2.88819326
7MP0004130_abnormal_muscle_cell2.86664233
8MP0003123_paternal_imprinting2.72880318
9MP0003300_gastrointestinal_ulcer2.72801435
10MP0002837_dystrophic_cardiac_calcinosis2.69505076
11MP0002009_preneoplasia2.65516692
12MP0003890_abnormal_embryonic-extraembry2.60287339
13MP0010352_gastrointestinal_tract_polyps2.58964203
14MP0002163_abnormal_gland_morphology2.41015999
15MP0000778_abnormal_nervous_system2.35635966
16MP0010307_abnormal_tumor_latency2.35378136
17MP0002653_abnormal_ependyma_morphology2.33015863
18MP0002877_abnormal_melanocyte_morpholog2.28697652
19MP0002396_abnormal_hematopoietic_system2.24959401
20MP0005389_reproductive_system_phenotype2.23999657
21MP0010234_abnormal_vibrissa_follicle2.23568715
22MP0002006_tumorigenesis2.23064770
23MP0004134_abnormal_chest_morphology2.19027231
24MP0004145_abnormal_muscle_electrophysio2.18883408
25MP0001440_abnormal_grooming_behavior2.14964662
26MP0006276_abnormal_autonomic_nervous2.14176493
27MP0003942_abnormal_urinary_system2.12630848
28MP0003705_abnormal_hypodermis_morpholog2.02131767
29MP0005076_abnormal_cell_differentiation2.01124547
30MP0004808_abnormal_hematopoietic_stem2.00842152
31MP0003879_abnormal_hair_cell1.97381520
32MP0006054_spinal_hemorrhage1.96166677
33MP0004885_abnormal_endolymph1.93589654
34MP0000049_abnormal_middle_ear1.92996774
35MP0008877_abnormal_DNA_methylation1.92592006
36MP0010094_abnormal_chromosome_stability1.91252564
37MP0000631_abnormal_neuroendocrine_gland1.84324595
38MP0001835_abnormal_antigen_presentation1.83098386
39MP0003121_genomic_imprinting1.79982723
40MP0002184_abnormal_innervation1.76485461
41MP0003763_abnormal_thymus_physiology1.73730889
42MP0010678_abnormal_skin_adnexa1.73178242
43MP0003303_peritoneal_inflammation1.70357710
44MP0000383_abnormal_hair_follicle1.68571043
45MP0003077_abnormal_cell_cycle1.68422179
46MP0003111_abnormal_nucleus_morphology1.66796087
47MP0009278_abnormal_bone_marrow1.66581242
48MP0000685_abnormal_immune_system1.63022606
49MP0003693_abnormal_embryo_hatching1.58117624
50MP0005671_abnormal_response_to1.56432264
51MP0001800_abnormal_humoral_immune1.55857443
52MP0000955_abnormal_spinal_cord1.54498459
53MP0001188_hyperpigmentation1.52311373
54MP0002398_abnormal_bone_marrow1.48244063
55MP0005409_darkened_coat_color1.47515598
56MP0000569_abnormal_digit_pigmentation1.47107162
57MP0008057_abnormal_DNA_replication1.46844110
58MP0005423_abnormal_somatic_nervous1.45341976
59MP0004947_skin_inflammation1.42666400
60MP0002272_abnormal_nervous_system1.42382135
61MP0004742_abnormal_vestibular_system1.41315925
62MP0008775_abnormal_heart_ventricle1.40663167
63MP0001545_abnormal_hematopoietic_system1.40554546
64MP0005397_hematopoietic_system_phenotyp1.40554546
65MP0009250_abnormal_appendicular_skeleto1.40318502
66MP0003938_abnormal_ear_development1.39038169
67MP0000465_gastrointestinal_hemorrhage1.36747950
68MP0002452_abnormal_antigen_presenting1.36529201
69MP0008438_abnormal_cutaneous_collagen1.35305727
70MP0008007_abnormal_cellular_replicative1.34925290
71MP0003566_abnormal_cell_adhesion1.33603366
72MP0002752_abnormal_somatic_nervous1.32417593
73MP0000703_abnormal_thymus_morphology1.32261176
74MP0002420_abnormal_adaptive_immunity1.28996172
75MP0000026_abnormal_inner_ear1.27681929
76MP0001819_abnormal_immune_cell1.26882640
77MP0004957_abnormal_blastocyst_morpholog1.26409464
78MP0001919_abnormal_reproductive_system1.24516572
79MP0002723_abnormal_immune_serum1.24424585
80MP0003937_abnormal_limbs/digits/tail_de1.23866000
81MP0000490_abnormal_crypts_of1.23597194
82MP0002089_abnormal_postnatal_growth/wei1.23354867
83MP0002722_abnormal_immune_system1.22825495
84MP0002733_abnormal_thermal_nociception1.22704591
85MP0003635_abnormal_synaptic_transmissio1.22081209
86MP0010155_abnormal_intestine_physiology1.21874087
87MP0002882_abnormal_neuron_morphology1.20409627
88MP0009384_cardiac_valve_regurgitation1.19668516
89MP0000716_abnormal_immune_system1.19629436
90MP0005379_endocrine/exocrine_gland_phen1.18900872
91MP0008789_abnormal_olfactory_epithelium1.17942956
92MP0002063_abnormal_learning/memory/cond1.17913270
93MP0000678_abnormal_parathyroid_gland1.17909041
94MP0000733_abnormal_muscle_development1.17382264
95MP0005000_abnormal_immune_tolerance1.16871731
96MP0000689_abnormal_spleen_morphology1.16173855
97MP0000534_abnormal_ureter_morphology1.16110947
98MP0003861_abnormal_nervous_system1.14331724
99MP0005387_immune_system_phenotype1.13798186
100MP0001790_abnormal_immune_system1.13798186
101MP0003119_abnormal_digestive_system1.12901254
102MP0001293_anophthalmia1.12388953
103MP0001873_stomach_inflammation1.11200188
104MP0005551_abnormal_eye_electrophysiolog1.10128261
105MP0000350_abnormal_cell_proliferation1.08875056
106MP0001963_abnormal_hearing_physiology1.08681529
107MP0002152_abnormal_brain_morphology1.08211156
108MP0002086_abnormal_extraembryonic_tissu1.07782401
109MP0002429_abnormal_blood_cell1.06376923
110MP0004197_abnormal_fetal_growth/weight/1.05743708
111MP0003453_abnormal_keratinocyte_physiol1.05287534
112MP0004019_abnormal_vitamin_homeostasis1.05146721
113MP0001730_embryonic_growth_arrest1.04956015
114MP0002557_abnormal_social/conspecific_i1.04487178
115MP0005195_abnormal_posterior_eye1.03373444
116MP0003436_decreased_susceptibility_to1.02939849
117MP0001970_abnormal_pain_threshold1.02867230
118MP0006072_abnormal_retinal_apoptosis1.02618832
119MP0009053_abnormal_anal_canal1.02073277
120MP0004142_abnormal_muscle_tone1.01098038
121MP0001853_heart_inflammation1.00877632
122MP0005464_abnormal_platelet_physiology1.00548401
123MP0001672_abnormal_embryogenesis/_devel0.99900675
124MP0005380_embryogenesis_phenotype0.99900675
125MP0002419_abnormal_innate_immunity0.99861430
126MP0002088_abnormal_embryonic_growth/wei0.99228938
127MP0009745_abnormal_behavioral_response0.99038499
128MP0004133_heterotaxia0.98518771
129MP0009333_abnormal_splenocyte_physiolog0.98474379
130MP0003880_abnormal_central_pattern0.98312830
131MP0003984_embryonic_growth_retardation0.97936548
132MP0005025_abnormal_response_to0.97583320
133MP0001286_abnormal_eye_development0.95848645
134MP0002405_respiratory_system_inflammati0.95722666
135MP0002249_abnormal_larynx_morphology0.94817879
136MP0005174_abnormal_tail_pigmentation0.94603335
137MP0003448_altered_tumor_morphology0.94309612
138MP0002019_abnormal_tumor_incidence0.94031096
139MP0003011_delayed_dark_adaptation0.93899251
140MP0000377_abnormal_hair_follicle0.93896867
141MP0005394_taste/olfaction_phenotype0.92542001
142MP0005499_abnormal_olfactory_system0.92542001
143MP0004085_abnormal_heartbeat0.91770750
144MP0002638_abnormal_pupillary_reflex0.91603632
145MP0002909_abnormal_adrenal_gland0.91068741
146MP0000428_abnormal_craniofacial_morphol0.91014046
147MP0005023_abnormal_wound_healing0.90326369
148MP0005646_abnormal_pituitary_gland0.89880526
149MP0009379_abnormal_foot_pigmentation0.89340355
150MP0002060_abnormal_skin_morphology0.89166103
151MP0009785_altered_susceptibility_to0.88770043
152MP0001486_abnormal_startle_reflex0.88765468
153MP0003755_abnormal_palate_morphology0.88207568
154MP0003567_abnormal_fetal_cardiomyocyte0.88106857
155MP0002095_abnormal_skin_pigmentation0.86328714
156MP0003136_yellow_coat_color0.86105878
157MP0002092_abnormal_eye_morphology0.85742422
158MP0002067_abnormal_sensory_capabilities0.85721106
159MP0004185_abnormal_adipocyte_glucose0.84030331
160MP0001879_abnormal_lymphatic_vessel0.83962337
161MP0003828_pulmonary_edema0.83696504
162MP0002138_abnormal_hepatobiliary_system0.83393568
163MP0002116_abnormal_craniofacial_bone0.82967918
164MP0002210_abnormal_sex_determination0.82598983
165MP0001915_intracranial_hemorrhage0.82598059
166MP0004859_abnormal_synaptic_plasticity0.82522261
167MP0004811_abnormal_neuron_physiology0.82032711
168MP0002734_abnormal_mechanical_nocicepti0.81645138
169MP0000427_abnormal_hair_cycle0.81515377
170MP0005275_abnormal_skin_tensile0.80739048
171MP0009115_abnormal_fat_cell0.80284277
172MP0001697_abnormal_embryo_size0.80166859
173MP0000230_abnormal_systemic_arterial0.79774544
174MP0002932_abnormal_joint_morphology0.79442032
175MP0002084_abnormal_developmental_patter0.79331789
176MP0002572_abnormal_emotion/affect_behav0.79305854
177MP0002938_white_spotting0.79224174
178MP0003045_fibrosis0.78707417
179MP0001845_abnormal_inflammatory_respons0.78683007
180MP0003866_abnormal_defecation0.77848172
181MP0009703_decreased_birth_body0.77663557
182MP0001542_abnormal_bone_strength0.77153020
183MP0005645_abnormal_hypothalamus_physiol0.76698210
184MP0002229_neurodegeneration0.76425713
185MP0002080_prenatal_lethality0.76271503
186MP0003183_abnormal_peptide_metabolism0.76244629
187MP0003091_abnormal_cell_migration0.76167519
188MP0003724_increased_susceptibility_to0.75510560
189MP0000371_diluted_coat_color0.74731279
190MP0005220_abnormal_exocrine_pancreas0.73760112
191MP0002928_abnormal_bile_duct0.73145928
192MP0000858_altered_metastatic_potential0.72958133
193MP0003122_maternal_imprinting0.72246050
194MP0001661_extended_life_span0.72192701

Predicted human phenotypes

RankGene SetZ-score
1Stenosis of the external auditory canal (HP:0000402)4.01041428
2Abnormal pancreas size (HP:0012094)4.00800449
3Osteomalacia (HP:0002749)3.85161265
4Decreased circulating renin level (HP:0003351)3.73825907
5Abnormality of the fingertips (HP:0001211)3.68405054
6Hematochezia (HP:0002573)3.63281325
7Nephronophthisis (HP:0000090)3.62201704
8Abnormality of the renal collecting system (HP:0004742)3.56432954
9Genetic anticipation (HP:0003743)3.55400406
10Volvulus (HP:0002580)3.48243750
11Progressive cerebellar ataxia (HP:0002073)3.46575632
12Short femoral neck (HP:0100864)3.39240915
13Diastasis recti (HP:0001540)3.33949501
14Abnormality of cochlea (HP:0000375)3.30461666
15T lymphocytopenia (HP:0005403)3.17403493
16Hepatoblastoma (HP:0002884)3.05120150
17Neoplasm of the adrenal cortex (HP:0100641)3.03853503
18Chronic hepatic failure (HP:0100626)3.02418752
19Osteolytic defects of the phalanges of the hand (HP:0009771)3.01877209
20Osteolytic defects of the hand bones (HP:0009699)3.01877209
21Abnormality of T cell number (HP:0011839)2.98998853
22Abnormality of the renal medulla (HP:0100957)2.94657673
23Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.92270902
24Pancreatic fibrosis (HP:0100732)2.90678497
25Subacute progressive viral hepatitis (HP:0006572)2.90196740
26Fibular hypoplasia (HP:0003038)2.88247069
27Septo-optic dysplasia (HP:0100842)2.86514440
28Molar tooth sign on MRI (HP:0002419)2.86363703
29Abnormality of midbrain morphology (HP:0002418)2.86363703
30Recurrent viral infections (HP:0004429)2.81542453
31Oligodontia (HP:0000677)2.79495882
32True hermaphroditism (HP:0010459)2.78487671
33Periauricular skin pits (HP:0100277)2.75310170
34Preauricular pit (HP:0004467)2.75310170
35Metabolic alkalosis (HP:0200114)2.72899348
36Mesomelia (HP:0003027)2.69608939
37Neonatal hypoglycemia (HP:0001998)2.69252937
38Abolished electroretinogram (ERG) (HP:0000550)2.67485811
39Aplasia/Hypoplasia of the fibula (HP:0006492)2.66790647
40Conjunctival hamartoma (HP:0100780)2.64428611
41Abnormality of the proximal phalanges of the hand (HP:0009834)2.63749881
42Adrenal hypoplasia (HP:0000835)2.59356491
43Thrombocytosis (HP:0001894)2.59119320
44Thyroiditis (HP:0100646)2.57842007
45Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.56611917
46Lip pit (HP:0100267)2.54674468
47Megalencephaly (HP:0001355)2.54549955
48Morphological abnormality of the inner ear (HP:0011390)2.51662806
49Pancreatic cysts (HP:0001737)2.50971624
50Abnormality of the phalanges of the 2nd finger (HP:0009541)2.49353824
51Asplenia (HP:0001746)2.48126455
52Anomalous pulmonary venous return (HP:0010772)2.46721647
53Abnormality of the phalanges of the 5th finger (HP:0004213)2.44625005
54Rectal prolapse (HP:0002035)2.44089010
55Morphological abnormality of the middle ear (HP:0008609)2.43240877
56Macroorchidism (HP:0000053)2.42300745
57Enlarged kidneys (HP:0000105)2.41383730
58Recurrent fungal infections (HP:0002841)2.39174794
59Aplasia/Hypoplasia of the spleen (HP:0010451)2.37977026
60Hypoplasia of the ulna (HP:0003022)2.37058421
61Abnormality of the right ventricle (HP:0001707)2.36419794
62Abnormality of DNA repair (HP:0003254)2.35133548
63Abnormality of the frontal sinuses (HP:0002687)2.32750522
64Abnormality of the middle phalanges of the toes (HP:0010183)2.30963883
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30476903
66Short 4th metacarpal (HP:0010044)2.30476903
67Cerebral aneurysm (HP:0004944)2.28350290
68Agitation (HP:0000713)2.27181131
69Cellulitis (HP:0100658)2.26467460
70Fibular aplasia (HP:0002990)2.21206987
71Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.20728827
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20153188
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.19766697
74Aortic aneurysm (HP:0004942)2.18383098
75IgM deficiency (HP:0002850)2.18307543
76Entropion (HP:0000621)2.17361975
77Spontaneous hematomas (HP:0007420)2.15543953
78Persistence of primary teeth (HP:0006335)2.15153960
79Short tibia (HP:0005736)2.14836947
80Radial bowing (HP:0002986)2.14034988
81Small hand (HP:0200055)2.13618841
82Acute myeloid leukemia (HP:0004808)2.13104847
83Chronic otitis media (HP:0000389)2.12900078
84Abnormality of the pulmonary veins (HP:0011718)2.11635384
85Abnormality of the corticospinal tract (HP:0002492)2.09691735
86Hamartoma of the eye (HP:0010568)2.09186416
87Abnormality of T cells (HP:0002843)2.08840878
88Eosinophilia (HP:0001880)2.07842392
89Intellectual disability, moderate (HP:0002342)2.07727742
90Cutaneous melanoma (HP:0012056)2.07703621
91Aplasia/hypoplasia of the femur (HP:0005613)2.07582976
92Visual hallucinations (HP:0002367)2.06162939
93Down-sloping shoulders (HP:0200021)2.05911610
94Eczematoid dermatitis (HP:0000976)2.05441570
95Aplasia/Hypoplasia of the patella (HP:0006498)2.04520767
96Goiter (HP:0000853)2.04487677
97Recurrent bronchitis (HP:0002837)2.04258120
98Cutis marmorata (HP:0000965)2.02422092
99Tubular atrophy (HP:0000092)2.02132726
100Furrowed tongue (HP:0000221)2.01473161
101Synostosis of carpal bones (HP:0005048)2.00708489
102Abnormality of B cell number (HP:0010975)2.00365980
103B lymphocytopenia (HP:0010976)2.00365980
104Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99791327
105Submucous cleft hard palate (HP:0000176)1.99727314
106Abnormal platelet volume (HP:0011876)1.98907209
107Ulnar bowing (HP:0003031)1.98830811
108Drooling (HP:0002307)1.98082443
109Abnormality of the 2nd finger (HP:0004100)1.97538515
110Short 1st metacarpal (HP:0010034)1.96807556
111Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96807556
112Long eyelashes (HP:0000527)1.95583036
113Arterial thrombosis (HP:0004420)1.95166208
114Chronic diarrhea (HP:0002028)1.95091121
115Abnormality of the nasal septum (HP:0000419)1.94528084
116Absent frontal sinuses (HP:0002688)1.93920742
117Impaired vibration sensation in the lower limbs (HP:0002166)1.92851689
118Prominent nose (HP:0000448)1.92516746
119Enlarged penis (HP:0000040)1.92500035
120Ectopic kidney (HP:0000086)1.92487791
121IgA deficiency (HP:0002720)1.92124460
122Patellar aplasia (HP:0006443)1.91995202
123Increased density of long bones (HP:0006392)1.91609777
124Colon cancer (HP:0003003)1.91470619
125Viral hepatitis (HP:0006562)1.91398229
126Porencephaly (HP:0002132)1.91127469
127Lymphopenia (HP:0001888)1.89633163
128Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.89631730
129Periodontitis (HP:0000704)1.89595020
130Dilatation of the ascending aorta (HP:0005111)1.89451626
131Mitral valve prolapse (HP:0001634)1.88040992
132Deviation of the thumb (HP:0009603)1.86720138
133Hypochromic microcytic anemia (HP:0004840)1.86684857
134Symphalangism affecting the phalanges of the hand (HP:0009773)1.86288152
135Clumsiness (HP:0002312)1.86172450
136Increased mean platelet volume (HP:0011877)1.85721511
137Blepharitis (HP:0000498)1.84460480
138Skin pits (HP:0100276)1.84108538
139Aplasia/Hypoplasia of the ulna (HP:0006495)1.83377644
140Gaze-evoked nystagmus (HP:0000640)1.83229171
141Abnormality of cells of the lymphoid lineage (HP:0012140)1.83044909
142Biliary tract neoplasm (HP:0100574)1.82470047
143Proximal placement of thumb (HP:0009623)1.82260707
144Hypoplasia of the uterus (HP:0000013)1.82089335
145Excessive salivation (HP:0003781)1.79872575
146Osteomyelitis (HP:0002754)1.79741293
147Abnormality of renin-angiotensin system (HP:0000847)1.79453311
148Specific learning disability (HP:0001328)1.79313337
149Abnormality of eosinophils (HP:0001879)1.78767189
150Sclerocornea (HP:0000647)1.78713690
151High pitched voice (HP:0001620)1.78377023
152Heterotopia (HP:0002282)1.77729568
153Increased nuchal translucency (HP:0010880)1.77425704
154Truncal obesity (HP:0001956)1.76833732
155Pustule (HP:0200039)1.76466050
156Vertebral arch anomaly (HP:0008438)1.76429051
157Asymmetry of the thorax (HP:0001555)1.76089243
158Cystic liver disease (HP:0006706)1.76068573
159Bony spicule pigmentary retinopathy (HP:0007737)1.75561842
160Papilloma (HP:0012740)1.75029902
161Verrucae (HP:0200043)1.75029902
162Patent foramen ovale (HP:0001655)1.74907003
163Myocardial infarction (HP:0001658)1.74172950
164Malignant gastrointestinal tract tumors (HP:0006749)1.73766944
165Gastrointestinal carcinoma (HP:0002672)1.73766944
166Colitis (HP:0002583)1.71908777
167Abnormality of chromosome stability (HP:0003220)1.71071872
168Combined immunodeficiency (HP:0005387)1.70764502
169Bicuspid aortic valve (HP:0001647)1.70741046
170Severe combined immunodeficiency (HP:0004430)1.70729060
171Ankle contracture (HP:0006466)1.70613248
172Amaurosis fugax (HP:0100576)1.70387627
173Abnormal delayed hypersensitivity skin test (HP:0002963)1.69478531
174Inflammation of the large intestine (HP:0002037)1.69137924
175Aortic dissection (HP:0002647)1.69079780
176Hypoplasia of the thymus (HP:0000778)1.68353634
177Autoimmune hemolytic anemia (HP:0001890)1.67636723
178Gastrointestinal inflammation (HP:0004386)1.67275480
179Narrow palate (HP:0000189)1.67033914
180Low anterior hairline (HP:0000294)1.64225122
181Myelodysplasia (HP:0002863)1.64001159
182Abnormality of the calcaneus (HP:0008364)1.63242628
183Hypochromic anemia (HP:0001931)1.61332932
184Deep philtrum (HP:0002002)1.61251350
185Leukocytosis (HP:0001974)1.60333305
186Granulocytopenia (HP:0001913)1.60190538
187Sandal gap (HP:0001852)1.59398352
188Transitional cell carcinoma of the bladder (HP:0006740)1.58697151
189Abnormality of the 4th metacarpal (HP:0010012)1.57347652
190Thin bony cortex (HP:0002753)1.56736860
191Recurrent bacterial skin infections (HP:0005406)1.56219464
192Premature rupture of membranes (HP:0001788)1.55033471
193Lymphoma (HP:0002665)1.54525077
194Abnormality of T cell physiology (HP:0011840)1.54111153
195Severe short stature (HP:0003510)1.53828041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK24.11810620
2FRK2.79707294
3EEF2K2.69732772
4MAP3K92.57896404
5TAF12.49670960
6WNK42.40892712
7PKN22.26490881
8CDK122.21517807
9SGK22.18009029
10LATS12.13249024
11MAP4K12.10099527
12MAP3K102.06375366
13RPS6KA22.05547886
14NEK22.05474892
15FGFR32.02521369
16STK101.99861434
17NTRK31.99752761
18CASK1.96647170
19CDC71.94252569
20MAP3K41.92439520
21TRIB31.88408691
22TYRO31.82674524
23STK111.79118047
24SGK2231.77585057
25SGK4941.77585057
26FGFR21.76662947
27NUAK11.75403344
28PINK11.74040443
29PTK61.73441306
30NTRK21.73431999
31ERBB21.69467842
32TYK21.68324172
33STK31.66652463
34CDK61.65955016
35JAK31.63327226
36SGK31.61575054
37STK41.60715105
38TTN1.60675439
39ADRBK21.55208325
40WNK11.54844356
41RPS6KA61.52668430
42MAP2K71.50864179
43PASK1.45939019
44GRK11.45739460
45LRRK21.45394927
46RPS6KC11.40932419
47RPS6KL11.40932419
48ACVR1B1.38142424
49SCYL21.35697079
50FGFR41.35474495
51JAK11.35154819
52ITK1.34204024
53PLK41.34089742
54SRPK11.32956707
55STK391.31511695
56RPS6KA41.30073426
57STK161.28710401
58FLT31.28416606
59MAP2K41.27675926
60BMPR1B1.27446249
61MKNK11.25574494
62CSF1R1.24986682
63MARK21.24360783
64TEC1.22954420
65TGFBR21.22707661
66SGK11.19024720
67TXK1.18064667
68CDK41.17865055
69TAOK31.17281299
70CAMK1D1.17074165
71PIM11.17034682
72TLK11.14434443
73TRPM71.12535429
74BTK1.11928883
75TSSK61.09138014
76DYRK21.08383850
77MKNK21.06466391
78AURKB1.04804003
79NEK91.00825680
80SIK11.00307680
81BRD41.00306608
82PAK30.99060831
83ATR0.96218574
84RPS6KB20.95327698
85BRSK20.94879263
86MAP3K80.93229240
87TNIK0.93100583
88JAK20.92790014
89CAMKK20.92531480
90ALK0.92332828
91EIF2AK10.91484288
92MELK0.90829644
93ZAP700.90809467
94PRKCH0.90623389
95PDGFRA0.90545358
96CSK0.90544413
97PDGFRB0.90322778
98TGFBR10.89617701
99MAP3K110.89493460
100CDK90.89304643
101KIT0.85269525
102HIPK20.85199905
103IRAK40.84993874
104DYRK1A0.84784874
105CAMKK10.84265278
106MAP3K140.81787207
107EPHA30.79821046
108PRKD20.79644003
109CHUK0.78123600
110MARK30.77066182
111PRKCG0.75962004
112WEE10.75706729
113LCK0.75062336
114DYRK30.75045293
115PRKCZ0.74156751
116GRK60.72961651
117EPHB10.72614560
118DYRK1B0.71443791
119ATM0.71439170
120CLK10.70892096
121HCK0.68164336
122AURKA0.68130147
123RPS6KA50.67504357
124BLK0.66205552
125PRKACA0.65797236
126CHEK10.65544770
127MTOR0.65337393
128PLK20.65316299
129FGFR10.64505791
130TTK0.63632772
131ZAK0.63587661
132MAP2K30.61504657
133BRAF0.60314692
134CAMK1G0.59394216
135STK240.58989179
136AKT30.58124006
137ADRBK10.57556217
138IKBKE0.56951469
139PNCK0.56084929
140BUB10.55944595
141PAK40.54736749
142PLK30.54545224
143AKT10.54137908
144TBK10.53391004
145PKN10.51971654
146CDK50.51232720
147INSRR0.51159282
148NLK0.51118270
149MAPK130.50839606
150PAK20.50783262
151PIK3CA0.50494109
152RIPK10.49880162
153MAPK40.47805755
154RPS6KA30.47506572
155CSNK1A1L0.47235118
156CHEK20.46503556
157RPS6KA10.46403824
158PLK10.45730698
159STK38L0.45713921
160MAPK110.45253444
161IKBKB0.45122970
162WNK30.45019853
163RPS6KB10.44743527
164DMPK0.44364936
165MAPK140.43836778
166PRKACG0.40596159
167MARK10.40176173
168GRK70.39837162
169CSNK1A10.39423686
170GSK3B0.37964167
171CAMK40.36275242
172CDK10.33592230

Predicted pathways (KEGG)

RankGene SetZ-score
1Cholinergic synapse_Homo sapiens_hsa047252.51775201
2Nicotine addiction_Homo sapiens_hsa050332.40431084
3Morphine addiction_Homo sapiens_hsa050322.29829480
4Glutamatergic synapse_Homo sapiens_hsa047242.29771144
5Type II diabetes mellitus_Homo sapiens_hsa049302.26076716
6Systemic lupus erythematosus_Homo sapiens_hsa053222.26007834
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.16263306
8Melanoma_Homo sapiens_hsa052182.09949260
9Primary immunodeficiency_Homo sapiens_hsa053401.99150370
10Antigen processing and presentation_Homo sapiens_hsa046121.96147865
11Serotonergic synapse_Homo sapiens_hsa047261.93622778
12Vitamin digestion and absorption_Homo sapiens_hsa049771.91621980
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.89034923
14Circadian entrainment_Homo sapiens_hsa047131.88632605
15Dopaminergic synapse_Homo sapiens_hsa047281.83639465
16Axon guidance_Homo sapiens_hsa043601.79610058
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77973398
18GABAergic synapse_Homo sapiens_hsa047271.77317182
19DNA replication_Homo sapiens_hsa030301.72496186
20Small cell lung cancer_Homo sapiens_hsa052221.72318112
21Hedgehog signaling pathway_Homo sapiens_hsa043401.72174016
22Measles_Homo sapiens_hsa051621.67070716
23Chronic myeloid leukemia_Homo sapiens_hsa052201.67000066
24MAPK signaling pathway_Homo sapiens_hsa040101.66274312
25* Cell cycle_Homo sapiens_hsa041101.65775652
26Viral carcinogenesis_Homo sapiens_hsa052031.61466083
27B cell receptor signaling pathway_Homo sapiens_hsa046621.60763019
28Oxytocin signaling pathway_Homo sapiens_hsa049211.54378552
29Phototransduction_Homo sapiens_hsa047441.51722801
30Leishmaniasis_Homo sapiens_hsa051401.47967231
31Non-homologous end-joining_Homo sapiens_hsa034501.46975716
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42565993
33Hematopoietic cell lineage_Homo sapiens_hsa046401.42474990
34Basal transcription factors_Homo sapiens_hsa030221.42203377
35Herpes simplex infection_Homo sapiens_hsa051681.41777765
36MicroRNAs in cancer_Homo sapiens_hsa052061.40341156
37Insulin secretion_Homo sapiens_hsa049111.39976363
38Basal cell carcinoma_Homo sapiens_hsa052171.39865495
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39374054
40Renin secretion_Homo sapiens_hsa049241.37701646
41p53 signaling pathway_Homo sapiens_hsa041151.36938664
42Cardiac muscle contraction_Homo sapiens_hsa042601.36408798
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.35840400
44Osteoclast differentiation_Homo sapiens_hsa043801.33048406
45Toxoplasmosis_Homo sapiens_hsa051451.29292264
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.27682492
47T cell receptor signaling pathway_Homo sapiens_hsa046601.27349804
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25556768
49Hepatitis B_Homo sapiens_hsa051611.24536199
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.23578055
51Wnt signaling pathway_Homo sapiens_hsa043101.22585237
52Prostate cancer_Homo sapiens_hsa052151.18297668
53HTLV-I infection_Homo sapiens_hsa051661.17342598
54Pancreatic cancer_Homo sapiens_hsa052121.16710528
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.14941393
56mTOR signaling pathway_Homo sapiens_hsa041501.12386008
57Retinol metabolism_Homo sapiens_hsa008301.12147915
58Long-term depression_Homo sapiens_hsa047301.12135448
59Long-term potentiation_Homo sapiens_hsa047201.12002072
60RNA transport_Homo sapiens_hsa030131.11225357
61mRNA surveillance pathway_Homo sapiens_hsa030151.11203247
62Cocaine addiction_Homo sapiens_hsa050301.10504650
63Lysine degradation_Homo sapiens_hsa003101.09932764
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08958919
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07266365
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06402899
67Spliceosome_Homo sapiens_hsa030401.05687586
68cAMP signaling pathway_Homo sapiens_hsa040241.05479491
69One carbon pool by folate_Homo sapiens_hsa006701.04511209
70Non-small cell lung cancer_Homo sapiens_hsa052231.04272388
71Ras signaling pathway_Homo sapiens_hsa040141.04271570
72Olfactory transduction_Homo sapiens_hsa047401.04081836
73FoxO signaling pathway_Homo sapiens_hsa040681.02782717
74Mismatch repair_Homo sapiens_hsa034301.02409054
75Platelet activation_Homo sapiens_hsa046111.02264425
76Viral myocarditis_Homo sapiens_hsa054161.02074042
77Apoptosis_Homo sapiens_hsa042101.01577312
78Gastric acid secretion_Homo sapiens_hsa049711.01556620
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01086660
80Acute myeloid leukemia_Homo sapiens_hsa052211.00974134
81Proteoglycans in cancer_Homo sapiens_hsa052051.00641258
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00468242
83Adherens junction_Homo sapiens_hsa045201.00401721
84Insulin resistance_Homo sapiens_hsa049310.99563940
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.99451316
86Rap1 signaling pathway_Homo sapiens_hsa040150.99121915
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98454278
88Hippo signaling pathway_Homo sapiens_hsa043900.97973224
89Calcium signaling pathway_Homo sapiens_hsa040200.97770102
90Base excision repair_Homo sapiens_hsa034100.97750114
91Influenza A_Homo sapiens_hsa051640.97452154
92Focal adhesion_Homo sapiens_hsa045100.96272321
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96254450
94Legionellosis_Homo sapiens_hsa051340.96123344
95Fanconi anemia pathway_Homo sapiens_hsa034600.92818703
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92669739
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90580808
98TNF signaling pathway_Homo sapiens_hsa046680.88311303
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87176656
100Selenocompound metabolism_Homo sapiens_hsa004500.85517988
101Prolactin signaling pathway_Homo sapiens_hsa049170.85452854
102Taste transduction_Homo sapiens_hsa047420.85411106
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85272335
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85182148
105Amphetamine addiction_Homo sapiens_hsa050310.82236253
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81381114
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80590699
108Endometrial cancer_Homo sapiens_hsa052130.80255811
109Chemokine signaling pathway_Homo sapiens_hsa040620.78228283
110Alcoholism_Homo sapiens_hsa050340.77021391
111Epstein-Barr virus infection_Homo sapiens_hsa051690.75701944
112Gap junction_Homo sapiens_hsa045400.75160408
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.75025799
114Glioma_Homo sapiens_hsa052140.74678030
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.74172940
116Colorectal cancer_Homo sapiens_hsa052100.72260146
117Hepatitis C_Homo sapiens_hsa051600.71497769
118ECM-receptor interaction_Homo sapiens_hsa045120.71353593
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71206483
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.71114050
121Malaria_Homo sapiens_hsa051440.70758872
122VEGF signaling pathway_Homo sapiens_hsa043700.70632345
123Nucleotide excision repair_Homo sapiens_hsa034200.70482123
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.70404581
125Glycerolipid metabolism_Homo sapiens_hsa005610.69329720
126Steroid biosynthesis_Homo sapiens_hsa001000.68241040
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.68040739
128Notch signaling pathway_Homo sapiens_hsa043300.68033258
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67157530
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66549515
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66541600
132Pathways in cancer_Homo sapiens_hsa052000.65808156
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65466671
134Inositol phosphate metabolism_Homo sapiens_hsa005620.65353595
135Tuberculosis_Homo sapiens_hsa051520.64957023
136Renal cell carcinoma_Homo sapiens_hsa052110.64934588
137Fatty acid biosynthesis_Homo sapiens_hsa000610.64157660
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63524591
139Caffeine metabolism_Homo sapiens_hsa002320.63214399
140Dilated cardiomyopathy_Homo sapiens_hsa054140.60790660
141Ribosome_Homo sapiens_hsa030100.60655091
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60357936
143Homologous recombination_Homo sapiens_hsa034400.60333826
144Protein export_Homo sapiens_hsa030600.59882108
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.59347359
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.58773349
147Thyroid cancer_Homo sapiens_hsa052160.58618001
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58542996
149Amoebiasis_Homo sapiens_hsa051460.56346253
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55930511
151Choline metabolism in cancer_Homo sapiens_hsa052310.55803206
152RNA degradation_Homo sapiens_hsa030180.55552693
153ErbB signaling pathway_Homo sapiens_hsa040120.55192684
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55051127
155Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54883491
156Pertussis_Homo sapiens_hsa051330.54626601
157Dorso-ventral axis formation_Homo sapiens_hsa043200.54378913
158Graft-versus-host disease_Homo sapiens_hsa053320.54307446
159GnRH signaling pathway_Homo sapiens_hsa049120.54208597
160ABC transporters_Homo sapiens_hsa020100.53787779
161PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53756730
162Staphylococcus aureus infection_Homo sapiens_hsa051500.53346862
163Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52438001
164alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51368354
165cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49326235
166Regulation of autophagy_Homo sapiens_hsa041400.47372260
167Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43503365
168Steroid hormone biosynthesis_Homo sapiens_hsa001400.42492188
169Sulfur relay system_Homo sapiens_hsa041220.41517166
170Tryptophan metabolism_Homo sapiens_hsa003800.39402575
171Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39136064
172Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38971693
173Linoleic acid metabolism_Homo sapiens_hsa005910.36786068
174TGF-beta signaling pathway_Homo sapiens_hsa043500.35969429

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