STAG3L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of B cell differentiation (GO:0045579)4.23360346
2pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.64870603
3iron-sulfur cluster assembly (GO:0016226)3.63231506
4metallo-sulfur cluster assembly (GO:0031163)3.63231506
5positive regulation of granulocyte differentiation (GO:0030854)3.60204378
6seminiferous tubule development (GO:0072520)3.57787306
7purine deoxyribonucleotide catabolic process (GO:0009155)3.56448714
8aggressive behavior (GO:0002118)3.52600823
9negative regulation of B cell apoptotic process (GO:0002903)3.51976204
10Peyers patch development (GO:0048541)3.42093980
11mucosal-associated lymphoid tissue development (GO:0048537)3.42093980
12purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.36630343
13pyrimidine nucleotide catabolic process (GO:0006244)3.36450240
14DNA integration (GO:0015074)3.35760557
15definitive hemopoiesis (GO:0060216)3.32513092
16negative regulation of telomere maintenance (GO:0032205)3.32345791
17regulation of B cell apoptotic process (GO:0002902)3.28981011
18deoxyribonucleotide catabolic process (GO:0009264)3.26966777
19autophagic vacuole fusion (GO:0000046)3.26810254
20Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21398097
21protein complex biogenesis (GO:0070271)3.19112038
22ubiquinone biosynthetic process (GO:0006744)3.18990698
23DNA deamination (GO:0045006)3.16485603
24mannosylation (GO:0097502)3.16149824
25preassembly of GPI anchor in ER membrane (GO:0016254)3.16056926
26purine deoxyribonucleotide metabolic process (GO:0009151)3.14430391
27phosphatidylglycerol biosynthetic process (GO:0006655)3.08560276
28deoxyribose phosphate catabolic process (GO:0046386)3.06176373
29peptidyl-histidine modification (GO:0018202)3.05770403
30purinergic nucleotide receptor signaling pathway (GO:0035590)3.05685752
31regulation of B cell differentiation (GO:0045577)3.03945630
32base-excision repair, AP site formation (GO:0006285)3.03630002
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01396853
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.01396853
35NADH dehydrogenase complex assembly (GO:0010257)3.01396853
36regulation of B cell receptor signaling pathway (GO:0050855)3.01133813
37positive regulation of gamma-delta T cell activation (GO:0046645)3.00623159
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.00341429
39histone H2A acetylation (GO:0043968)3.00134223
40cellular response to exogenous dsRNA (GO:0071360)2.96852678
41purine nucleotide salvage (GO:0032261)2.96424471
42mismatch repair (GO:0006298)2.95155923
43GPI anchor biosynthetic process (GO:0006506)2.92470210
44mitochondrial respiratory chain complex assembly (GO:0033108)2.90504630
45RNA destabilization (GO:0050779)2.89041306
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.85092996
47GPI anchor metabolic process (GO:0006505)2.84593455
48nucleotide salvage (GO:0043173)2.84098085
49negative thymic T cell selection (GO:0045060)2.84015883
50ubiquinone metabolic process (GO:0006743)2.83497101
51cell wall macromolecule catabolic process (GO:0016998)2.83249418
52estrogen biosynthetic process (GO:0006703)2.82904290
53histone H3-K9 methylation (GO:0051567)2.82447291
54mast cell degranulation (GO:0043303)2.82127261
55mast cell activation involved in immune response (GO:0002279)2.82127261
56regulation of gamma-delta T cell differentiation (GO:0045586)2.81245442
57cytochrome complex assembly (GO:0017004)2.74016836
58respiratory chain complex IV assembly (GO:0008535)2.71604664
592-deoxyribonucleotide metabolic process (GO:0009394)2.71216225
60pyrimidine dimer repair (GO:0006290)2.71082525
61deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.70287317
62organelle membrane fusion (GO:0090174)2.69472196
63axoneme assembly (GO:0035082)2.65721844
64regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.63063861
65positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.63063861
66positive regulation of amino acid transport (GO:0051957)2.61473650
67GMP metabolic process (GO:0046037)2.61040475
68fucose catabolic process (GO:0019317)2.59925335
69L-fucose metabolic process (GO:0042354)2.59925335
70L-fucose catabolic process (GO:0042355)2.59925335
71quinone biosynthetic process (GO:1901663)2.59301060
72regulation of granulocyte differentiation (GO:0030852)2.57246653
73adenosine metabolic process (GO:0046085)2.55485740
74negative T cell selection (GO:0043383)2.55235250
75branched-chain amino acid metabolic process (GO:0009081)2.55170272
76regulation of telomere maintenance (GO:0032204)2.53798976
77actin nucleation (GO:0045010)2.51448760
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.48294853
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.48294853
80branched-chain amino acid catabolic process (GO:0009083)2.48174904
81pseudouridine synthesis (GO:0001522)2.48155227
82purine-containing compound salvage (GO:0043101)2.47521747
83cell wall macromolecule metabolic process (GO:0044036)2.46084625
84protein polyglutamylation (GO:0018095)2.45842505
85regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.44079423
86deoxyribose phosphate metabolic process (GO:0019692)2.43729625
87mRNA splice site selection (GO:0006376)2.42403230
88positive regulation of T cell differentiation in thymus (GO:0033089)2.41018825
89DNA dealkylation (GO:0035510)2.38617312
90positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.38117317
91histone H3-K9 modification (GO:0061647)2.37398179
92regulation of germinal center formation (GO:0002634)2.36071111
93rRNA modification (GO:0000154)2.32353180
94protein deneddylation (GO:0000338)2.32311033
95tRNA modification (GO:0006400)2.32108581
96negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.31481917
97reciprocal meiotic recombination (GO:0007131)2.30692188
98reciprocal DNA recombination (GO:0035825)2.30692188
99DNA demethylation (GO:0080111)2.29014176
100positive regulation of defense response to virus by host (GO:0002230)2.28629279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.08896495
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.65942906
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.37788342
4ZNF274_21170338_ChIP-Seq_K562_Hela3.00852369
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93407390
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88907248
7SCL_19346495_ChIP-Seq_HPC-7_Human2.85427614
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75550214
9VDR_23849224_ChIP-Seq_CD4+_Human2.72585631
10CIITA_25753668_ChIP-Seq_RAJI_Human2.63115410
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55823383
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.55471844
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.47859627
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.44681782
15FOXP3_21729870_ChIP-Seq_TREG_Human2.36564688
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24909959
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.22484009
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05348391
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04299635
20VDR_21846776_ChIP-Seq_THP-1_Human1.94468194
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88866287
22MYB_26560356_Chip-Seq_TH2_Human1.88761370
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88367515
24CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84976882
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82508105
26IGF1R_20145208_ChIP-Seq_DFB_Human1.82316994
27GABP_19822575_ChIP-Seq_HepG2_Human1.79102202
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77206345
29SPI1_23547873_ChIP-Seq_NB4_Human1.76006159
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74904561
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.72659983
32BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.68897483
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66134497
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64356342
35KDM5A_27292631_Chip-Seq_BREAST_Human1.61764277
36UTX_26944678_Chip-Seq_JUKART_Human1.60421386
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59045635
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58315505
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57452399
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55805570
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53806092
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51334301
43* ELF1_20517297_ChIP-Seq_JURKAT_Human1.49233971
44IRF1_19129219_ChIP-ChIP_H3396_Human1.49124731
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48988919
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46340449
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45132674
48MYB_26560356_Chip-Seq_TH1_Human1.44468135
49FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44330397
50BCL6_27268052_Chip-Seq_Bcells_Human1.44010296
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.41063651
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40061853
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.39657260
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38948651
55* MAF_26560356_Chip-Seq_TH2_Human1.38605469
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37230955
57GATA3_27048872_Chip-Seq_THYMUS_Human1.33957505
58MYC_22102868_ChIP-Seq_BL_Human1.33589500
59VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32768945
60XRN2_22483619_ChIP-Seq_HELA_Human1.32686219
61ELK1_19687146_ChIP-ChIP_HELA_Human1.29140667
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27116051
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25164494
64GATA3_26560356_Chip-Seq_TH2_Human1.24696454
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23331210
66VDR_24763502_ChIP-Seq_THP-1_Human1.22452102
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21034915
68DCP1A_22483619_ChIP-Seq_HELA_Human1.19139278
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18982649
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18300192
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16821035
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.15862514
73RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15436629
74E2F1_20622854_ChIP-Seq_HELA_Human1.14917361
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14192637
76RUNX_20019798_ChIP-Seq_JUKART_Human1.13939188
77MAF_26560356_Chip-Seq_TH1_Human1.12456211
78TP53_22573176_ChIP-Seq_HFKS_Human1.12228442
79YY1_22570637_ChIP-Seq_MALME-3M_Human1.11624156
80P300_27268052_Chip-Seq_Bcells_Human1.11299653
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.10440729
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.10390606
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09455746
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09381642
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07540577
86MYC_18940864_ChIP-ChIP_HL60_Human1.07378802
87* PHF8_20622854_ChIP-Seq_HELA_Human1.07236704
88ERA_21632823_ChIP-Seq_H3396_Human1.05819719
89TTF2_22483619_ChIP-Seq_HELA_Human1.05324427
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04418259
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04359416
92* BCOR_27268052_Chip-Seq_Bcells_Human1.02540575
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01719161
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99978191
95P68_20966046_ChIP-Seq_HELA_Human0.99647227
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99286095
97FOXP1_21924763_ChIP-Seq_HESCs_Human0.98362547
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91803705
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91720184
100NANOG_20526341_ChIP-Seq_ESCs_Human0.90472157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.26201052
2MP0005397_hematopoietic_system_phenotyp3.11729167
3MP0001545_abnormal_hematopoietic_system3.11729167
4MP0001986_abnormal_taste_sensitivity2.95116626
5MP0008058_abnormal_DNA_repair2.70041096
6MP0000465_gastrointestinal_hemorrhage2.57838618
7MP0001835_abnormal_antigen_presentation2.36687802
8MP0002396_abnormal_hematopoietic_system2.34170440
9MP0008995_early_reproductive_senescence2.33540901
10MP0005075_abnormal_melanosome_morpholog2.31300250
11MP0004147_increased_porphyrin_level2.29771318
12MP0000372_irregular_coat_pigmentation2.12552197
13MP0001968_abnormal_touch/_nociception2.04146283
14MP0003763_abnormal_thymus_physiology1.94459384
15MP0008877_abnormal_DNA_methylation1.88823646
16MP0003786_premature_aging1.86117311
17MP0001764_abnormal_homeostasis1.78721918
18MP0003718_maternal_effect1.76479989
19MP0003656_abnormal_erythrocyte_physiolo1.75575401
20MP0005174_abnormal_tail_pigmentation1.75212640
21MP0009697_abnormal_copulation1.73209696
22MP0005645_abnormal_hypothalamus_physiol1.67794035
23MP0002398_abnormal_bone_marrow1.66370258
24MP0001800_abnormal_humoral_immune1.65061888
25MP0010094_abnormal_chromosome_stability1.58784472
26MP0000689_abnormal_spleen_morphology1.56721943
27MP0003806_abnormal_nucleotide_metabolis1.54918422
28MP0002420_abnormal_adaptive_immunity1.47149981
29MP0006036_abnormal_mitochondrial_physio1.46466751
30MP0001819_abnormal_immune_cell1.45335980
31MP0002736_abnormal_nociception_after1.44241333
32MP0004808_abnormal_hematopoietic_stem1.43899155
33MP0005551_abnormal_eye_electrophysiolog1.42791068
34MP0005084_abnormal_gallbladder_morpholo1.42057081
35MP0002723_abnormal_immune_serum1.41007820
36MP0008875_abnormal_xenobiotic_pharmacok1.40169445
37MP0002722_abnormal_immune_system1.38552591
38MP0000716_abnormal_immune_system1.37411293
39MP0002132_abnormal_respiratory_system1.36826426
40MP0000015_abnormal_ear_pigmentation1.36116244
41MP0005000_abnormal_immune_tolerance1.35892935
42MP0002452_abnormal_antigen_presenting1.34239465
43MP0003724_increased_susceptibility_to1.33731197
44MP0002735_abnormal_chemical_nociception1.32101734
45MP0000703_abnormal_thymus_morphology1.27856547
46MP0003436_decreased_susceptibility_to1.27494231
47MP0002822_catalepsy1.27132166
48MP0005464_abnormal_platelet_physiology1.26252182
49MP0002429_abnormal_blood_cell1.24341914
50MP0005025_abnormal_response_to1.22922903
51MP0002653_abnormal_ependyma_morphology1.22607834
52MP0003172_abnormal_lysosome_physiology1.21527641
53MP0002019_abnormal_tumor_incidence1.20179812
54MP0002419_abnormal_innate_immunity1.19122123
55MP0005646_abnormal_pituitary_gland1.17988197
56MP0002148_abnormal_hypersensitivity_rea1.08685550
57MP0008057_abnormal_DNA_replication1.06370597
58MP0001529_abnormal_vocalization1.03794192
59MP0005410_abnormal_fertilization1.00932840
60MP0002405_respiratory_system_inflammati1.00677299
61MP0005671_abnormal_response_to1.00516374
62MP0001873_stomach_inflammation1.00119927
63MP0009785_altered_susceptibility_to0.99852895
64MP0008007_abnormal_cellular_replicative0.99663523
65MP0004043_abnormal_pH_regulation0.98899311
66MP0006276_abnormal_autonomic_nervous0.95804845
67MP0006292_abnormal_olfactory_placode0.94718581
68MP0000681_abnormal_thyroid_gland0.93016114
69MP0002095_abnormal_skin_pigmentation0.91568003
70MP0009764_decreased_sensitivity_to0.91105293
71MP0009333_abnormal_splenocyte_physiolog0.89708753
72MP0005394_taste/olfaction_phenotype0.88037170
73MP0005499_abnormal_olfactory_system0.88037170
74MP0005535_abnormal_body_temperature0.87981332
75MP0002102_abnormal_ear_morphology0.87806956
76MP0005220_abnormal_exocrine_pancreas0.87486238
77MP0001790_abnormal_immune_system0.87427457
78MP0005387_immune_system_phenotype0.87427457
79MP0003698_abnormal_male_reproductive0.84810643
80MP0001929_abnormal_gametogenesis0.84695587
81MP0009765_abnormal_xenobiotic_induced0.84125289
82MP0002638_abnormal_pupillary_reflex0.83995201
83MP0006035_abnormal_mitochondrial_morpho0.83685141
84MP0005367_renal/urinary_system_phenotyp0.83439903
85MP0000516_abnormal_urinary_system0.83439903
86MP0008872_abnormal_physiological_respon0.83399850
87MP0008789_abnormal_olfactory_epithelium0.83354517
88MP0008873_increased_physiological_sensi0.79242414
89MP0008961_abnormal_basal_metabolism0.78565279
90MP0003111_abnormal_nucleus_morphology0.77524716
91MP0003880_abnormal_central_pattern0.77439774
92MP0004142_abnormal_muscle_tone0.76854667
93MP0001501_abnormal_sleep_pattern0.74437585
94MP0008469_abnormal_protein_level0.73551033
95MP0003787_abnormal_imprinting0.73503044
96MP0005266_abnormal_metabolism0.73040783
97MP0002928_abnormal_bile_duct0.73015712
98MP0005670_abnormal_white_adipose0.72438291
99MP0006072_abnormal_retinal_apoptosis0.69908349
100MP0001845_abnormal_inflammatory_respons0.69179907

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)4.33696911
2Microvesicular hepatic steatosis (HP:0001414)4.11349222
3Agammaglobulinemia (HP:0004432)4.05336086
4Severe combined immunodeficiency (HP:0004430)3.29719546
5Abnormal protein glycosylation (HP:0012346)3.29067917
6Abnormal glycosylation (HP:0012345)3.29067917
7Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.29067917
8Abnormal protein N-linked glycosylation (HP:0012347)3.29067917
9Attenuation of retinal blood vessels (HP:0007843)3.23421414
10Abnormality of B cell number (HP:0010975)3.18485704
11Elevated erythrocyte sedimentation rate (HP:0003565)3.15405580
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.03296106
13Medial flaring of the eyebrow (HP:0010747)2.95101204
14Hepatocellular necrosis (HP:0001404)2.94517620
15Abnormality of the heme biosynthetic pathway (HP:0010472)2.93380471
16B lymphocytopenia (HP:0010976)2.91417121
17Chronic mucocutaneous candidiasis (HP:0002728)2.90797186
18Recurrent cutaneous fungal infections (HP:0011370)2.90797186
19Type I transferrin isoform profile (HP:0003642)2.87866542
20Decreased electroretinogram (ERG) amplitude (HP:0000654)2.85646332
21Congenital stationary night blindness (HP:0007642)2.85118363
22Tubulointerstitial nephritis (HP:0001970)2.80221228
23Thrombocytosis (HP:0001894)2.71830462
24Recurrent fungal infections (HP:0002841)2.71654694
25Progressive microcephaly (HP:0000253)2.66120978
26Abnormality of the prostate (HP:0008775)2.65334821
27Nephronophthisis (HP:0000090)2.56456111
28Hepatic necrosis (HP:0002605)2.54169604
29Mitochondrial inheritance (HP:0001427)2.53188774
30Granulocytopenia (HP:0001913)2.52211090
31Dicarboxylic aciduria (HP:0003215)2.52132283
32Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52132283
33Congenital primary aphakia (HP:0007707)2.49188112
34Nephrogenic diabetes insipidus (HP:0009806)2.48585679
35Stomatitis (HP:0010280)2.45891293
36Cerebellar dysplasia (HP:0007033)2.45889694
37Gait imbalance (HP:0002141)2.43826492
38Abnormality of T cell physiology (HP:0011840)2.41660626
39Increased muscle lipid content (HP:0009058)2.38452373
40Acute lymphatic leukemia (HP:0006721)2.33951827
41Combined immunodeficiency (HP:0005387)2.30275125
42Increased intramyocellular lipid droplets (HP:0012240)2.29599596
43Abnormality of midbrain morphology (HP:0002418)2.27605874
44Molar tooth sign on MRI (HP:0002419)2.27605874
45Increased CSF lactate (HP:0002490)2.26425552
46Abnormal mitochondria in muscle tissue (HP:0008316)2.25861937
47Myositis (HP:0100614)2.25747610
48Abnormal rod and cone electroretinograms (HP:0008323)2.25173606
49Reduced antithrombin III activity (HP:0001976)2.18950468
50Decreased central vision (HP:0007663)2.18761873
51Increased serum lactate (HP:0002151)2.16560475
52Renal cortical cysts (HP:0000803)2.15582604
53Ketosis (HP:0001946)2.14010888
54Pancreatic cysts (HP:0001737)2.11503366
55Abolished electroretinogram (ERG) (HP:0000550)2.10883086
56Prolonged bleeding time (HP:0003010)2.09724888
57Abnormality of eosinophils (HP:0001879)2.09632064
58Seborrheic dermatitis (HP:0001051)2.06624582
59Thyroiditis (HP:0100646)2.05644232
60Stomach cancer (HP:0012126)2.05021813
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04874791
62Retinal dysplasia (HP:0007973)2.03971929
63Neonatal respiratory distress (HP:0002643)2.03719666
64Recurrent viral infections (HP:0004429)2.03377129
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01775784
66Abnormality of T cells (HP:0002843)2.00932348
67Acute necrotizing encephalopathy (HP:0006965)2.00386023
68Abnormality of the renal medulla (HP:0100957)2.00369049
69Ketoacidosis (HP:0001993)2.00230923
70Eosinophilia (HP:0001880)1.99796036
71Chronic hepatic failure (HP:0100626)1.99114134
72Lactic acidosis (HP:0003128)1.98382380
73Bony spicule pigmentary retinopathy (HP:0007737)1.95107023
74Abnormality of male internal genitalia (HP:0000022)1.91764872
75Meningitis (HP:0001287)1.91047399
76Encephalitis (HP:0002383)1.89446427
773-Methylglutaconic aciduria (HP:0003535)1.88638901
78Abnormality of transition element cation homeostasis (HP:0011030)1.88203446
79Aplastic anemia (HP:0001915)1.87815789
80Pustule (HP:0200039)1.87501723
81Dyschromatopsia (HP:0007641)1.87143010
82Macular degeneration (HP:0000608)1.86703549
83Amyotrophic lateral sclerosis (HP:0007354)1.86456654
84Abnormality of the renal cortex (HP:0011035)1.86451275
85Type II lissencephaly (HP:0007260)1.85591290
86Leukocytosis (HP:0001974)1.83448317
87Optic disc pallor (HP:0000543)1.83137793
88Basal cell carcinoma (HP:0002671)1.82609850
89Cerebral palsy (HP:0100021)1.81794745
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81580277
91Retinitis pigmentosa (HP:0000510)1.80863019
92Chest pain (HP:0100749)1.80231697
93Protruding tongue (HP:0010808)1.80135179
94Abnormality of DNA repair (HP:0003254)1.80128202
95Cerebral edema (HP:0002181)1.79262196
96Ragged-red muscle fibers (HP:0003200)1.79190235
97Acute encephalopathy (HP:0006846)1.77749809
98Abnormality of lateral ventricle (HP:0030047)1.77475966
99Methylmalonic aciduria (HP:0012120)1.77299170
100Absent thumb (HP:0009777)1.76383539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.49584906
2TAOK34.08313793
3MAP4K23.01079525
4KIT2.73746190
5MAP4K12.64310311
6FLT32.55265635
7VRK22.44135680
8TNK22.29387503
9NUAK12.19009061
10MAPK132.12638466
11KDR1.72794414
12SYK1.70850219
13FES1.66262759
14MAP3K141.64514724
15ZAK1.62188949
16TXK1.62148873
17GRK61.57980645
18SIK21.57808713
19CSF1R1.55803073
20BTK1.54732115
21TBK11.47077849
22IKBKB1.44784206
23TEC1.44356229
24FRK1.42047143
25RPS6KA41.33643203
26MAP3K41.26446006
27IKBKE1.25799830
28ADRBK21.23992662
29CCNB11.20698744
30VRK11.18998834
31TESK21.16501650
32ERN11.13761717
33ATR1.11805910
34JAK31.08800284
35MAP2K71.06233377
36INSRR1.05722680
37ITK1.05583783
38BLK1.03521775
39STK161.02042235
40DAPK21.00527143
41BMPR1B1.00200360
42MAP2K30.99433869
43LYN0.99112538
44SCYL20.97983064
45SRPK10.92934966
46WNK30.92358609
47MAP2K60.90872338
48DYRK30.90709200
49LCK0.90653006
50CDK30.86773102
51MAP3K110.81755166
52PBK0.81309927
53MAP3K70.81031034
54GRK10.76884928
55CSNK1G10.76727962
56PRKCQ0.76061418
57CSNK1G30.76024197
58RPS6KA50.74610137
59SIK30.74255436
60DYRK20.73199526
61HCK0.71531958
62MARK30.70281853
63MATK0.69383275
64PIM20.68931812
65CSNK1A1L0.68264031
66PINK10.67408329
67MAPK150.67080588
68EIF2AK30.66928023
69CDK40.64880680
70MAP2K40.63573038
71ZAP700.62981827
72MAP3K130.62186259
73PIM10.59852495
74PIK3CG0.56773381
75MAP2K20.51000990
76MAPK70.50169127
77ABL10.48766681
78BRD40.48464279
79ATM0.47455031
80TRIM280.46507093
81RPS6KA60.45970999
82PRKAA10.45927884
83PTK2B0.45879739
84MAPK30.45276811
85DAPK10.45122228
86CDC70.44097654
87MAPKAPK50.43204934
88DYRK1A0.41073358
89CSNK1G20.40781164
90TYK20.38940624
91MAPKAPK30.38620310
92BCR0.37992127
93ADRBK10.37642539
94NME20.37361476
95TNIK0.36306131
96PKN10.35977748
97RPS6KL10.35836118
98RPS6KC10.35836118
99MAP3K60.34789511
100TLK10.34497332

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.15722275
2Primary immunodeficiency_Homo sapiens_hsa053403.14834569
3Homologous recombination_Homo sapiens_hsa034402.87967583
4Fanconi anemia pathway_Homo sapiens_hsa034602.86709785
5Base excision repair_Homo sapiens_hsa034102.80335906
6RNA polymerase_Homo sapiens_hsa030202.28028687
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.17074311
8Asthma_Homo sapiens_hsa053102.13048253
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08409927
10Non-homologous end-joining_Homo sapiens_hsa034502.08314905
11Phototransduction_Homo sapiens_hsa047441.94264468
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.85797159
13Other glycan degradation_Homo sapiens_hsa005111.73724091
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71255403
15Regulation of autophagy_Homo sapiens_hsa041401.70591500
16Allograft rejection_Homo sapiens_hsa053301.65618372
17DNA replication_Homo sapiens_hsa030301.65124557
18Basal transcription factors_Homo sapiens_hsa030221.60502482
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55966400
20Proteasome_Homo sapiens_hsa030501.53170671
21Type I diabetes mellitus_Homo sapiens_hsa049401.51169824
22Pyrimidine metabolism_Homo sapiens_hsa002401.51051773
23Butanoate metabolism_Homo sapiens_hsa006501.48307725
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45205637
25Autoimmune thyroid disease_Homo sapiens_hsa053201.45103860
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44481438
27RNA degradation_Homo sapiens_hsa030181.44392923
28Spliceosome_Homo sapiens_hsa030401.43797839
29Nucleotide excision repair_Homo sapiens_hsa034201.43074827
30Graft-versus-host disease_Homo sapiens_hsa053321.38714513
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35392546
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.33668680
33Mismatch repair_Homo sapiens_hsa034301.30126542
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29576300
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26393072
36Peroxisome_Homo sapiens_hsa041461.25317694
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24055070
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23258244
39Ether lipid metabolism_Homo sapiens_hsa005651.21726555
40Herpes simplex infection_Homo sapiens_hsa051681.17716078
41Fatty acid elongation_Homo sapiens_hsa000621.16691693
42Purine metabolism_Homo sapiens_hsa002301.15060763
43Hematopoietic cell lineage_Homo sapiens_hsa046401.14678621
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13241762
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11448231
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.10938997
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03540743
48Antigen processing and presentation_Homo sapiens_hsa046121.03179512
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02050338
50Selenocompound metabolism_Homo sapiens_hsa004500.99915272
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97475704
52Leishmaniasis_Homo sapiens_hsa051400.94972351
53Olfactory transduction_Homo sapiens_hsa047400.93863338
54Propanoate metabolism_Homo sapiens_hsa006400.92044089
55RNA transport_Homo sapiens_hsa030130.90713305
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90347829
57Linoleic acid metabolism_Homo sapiens_hsa005910.89928566
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87822169
59Taste transduction_Homo sapiens_hsa047420.86262117
60Parkinsons disease_Homo sapiens_hsa050120.85666514
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.83871083
62Arachidonic acid metabolism_Homo sapiens_hsa005900.81016478
63Acute myeloid leukemia_Homo sapiens_hsa052210.80606895
64Oxidative phosphorylation_Homo sapiens_hsa001900.74177714
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69027317
66mRNA surveillance pathway_Homo sapiens_hsa030150.68685614
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.68120985
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.67736385
69Platelet activation_Homo sapiens_hsa046110.65999788
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.65256328
71Nicotine addiction_Homo sapiens_hsa050330.63752047
72Epstein-Barr virus infection_Homo sapiens_hsa051690.63144787
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62903121
74Lysine degradation_Homo sapiens_hsa003100.59611081
75Huntingtons disease_Homo sapiens_hsa050160.56816929
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54198498
77Circadian rhythm_Homo sapiens_hsa047100.54148660
78Staphylococcus aureus infection_Homo sapiens_hsa051500.53685932
79Measles_Homo sapiens_hsa051620.53599304
80Influenza A_Homo sapiens_hsa051640.53588762
81Metabolic pathways_Homo sapiens_hsa011000.52472590
82ABC transporters_Homo sapiens_hsa020100.52143645
83Shigellosis_Homo sapiens_hsa051310.49180591
84Tryptophan metabolism_Homo sapiens_hsa003800.48046289
85Viral myocarditis_Homo sapiens_hsa054160.45231785
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.44654836
87Fatty acid metabolism_Homo sapiens_hsa012120.44179651
88Rheumatoid arthritis_Homo sapiens_hsa053230.44128033
89N-Glycan biosynthesis_Homo sapiens_hsa005100.41262495
90One carbon pool by folate_Homo sapiens_hsa006700.40559483
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37414274
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36485972
93Ribosome_Homo sapiens_hsa030100.36024716
94Tuberculosis_Homo sapiens_hsa051520.35343325
95B cell receptor signaling pathway_Homo sapiens_hsa046620.34738460
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.33636203
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32024258
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31800001
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31693373
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.27648632

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