ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.16658691
2	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.45076857
3	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.45076857
4	NADH dehydrogenase complex assembly (GO:0010257)	4.45076857
5	protein complex biogenesis (GO:0070271)	4.40124615
6	mitochondrial respiratory chain complex assembly (GO:0033108)	4.18962860
7	fucose catabolic process (GO:0019317)	4.08507812
8	L-fucose metabolic process (GO:0042354)	4.08507812
9	L-fucose catabolic process (GO:0042355)	4.08507812
10	preassembly of GPI anchor in ER membrane (GO:0016254)	3.95286195
11	respiratory chain complex IV assembly (GO:0008535)	3.74452332
12	centriole replication (GO:0007099)	3.74138830
13	behavioral response to nicotine (GO:0035095)	3.71310848
14	response to pheromone (GO:0019236)	3.66923012
15	mannosylation (GO:0097502)	3.64878333
16	cytochrome complex assembly (GO:0017004)	3.54533217
17	replication fork processing (GO:0031297)	3.29390628
18	base-excision repair, AP site formation (GO:0006285)	3.27352288
19	negative regulation of telomere maintenance (GO:0032205)	3.22816076
20	reciprocal DNA recombination (GO:0035825)	3.19188074
21	reciprocal meiotic recombination (GO:0007131)	3.19188074
22	double-strand break repair via homologous recombination (GO:0000724)	3.09837633
23	pseudouridine synthesis (GO:0001522)	3.08990450
24	recombinational repair (GO:0000725)	3.08618516
25	protein-cofactor linkage (GO:0018065)	3.08037735
26	rRNA modification (GO:0000154)	3.07259803
27	cellular ketone body metabolic process (GO:0046950)	3.05707795
28	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.05287231
29	GPI anchor metabolic process (GO:0006505)	2.97856498
30	regulation of cilium movement (GO:0003352)	2.97730489
31	axoneme assembly (GO:0035082)	2.97305615
32	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.96468020
33	ATP synthesis coupled proton transport (GO:0015986)	2.96468020
34	positive regulation of prostaglandin secretion (GO:0032308)	2.95353434
35	indolalkylamine metabolic process (GO:0006586)	2.93750776
36	platelet dense granule organization (GO:0060155)	2.90005948
37	DNA double-strand break processing (GO:0000729)	2.89496908
38	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.87886890
39	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.87162827
40	tRNA processing (GO:0008033)	2.87076631
41	sulfation (GO:0051923)	2.86460202
42	ubiquinone biosynthetic process (GO:0006744)	2.86222417
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.86069690
44	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.86069690
45	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.85878683
46	peptidyl-histidine modification (GO:0018202)	2.85332610
47	tryptophan metabolic process (GO:0006568)	2.83777845
48	protein polyglutamylation (GO:0018095)	2.83071633
49	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.81490553
50	DNA demethylation (GO:0080111)	2.79862482
51	mitochondrial RNA metabolic process (GO:0000959)	2.78159579
52	tRNA modification (GO:0006400)	2.76363829
53	rRNA methylation (GO:0031167)	2.76209451
54	indole-containing compound catabolic process (GO:0042436)	2.75975777
55	indolalkylamine catabolic process (GO:0046218)	2.75975777
56	tryptophan catabolic process (GO:0006569)	2.75975777
57	GPI anchor biosynthetic process (GO:0006506)	2.75832398
58	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.75174248
59	ketone body metabolic process (GO:1902224)	2.75020916
60	maturation of 5.8S rRNA (GO:0000460)	2.74940043
61	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.72152297
62	regulation of mitotic spindle checkpoint (GO:1903504)	2.72152297
63	NAD biosynthetic process (GO:0009435)	2.69846201
64	epithelial cilium movement (GO:0003351)	2.69486667
65	neural tube formation (GO:0001841)	2.68219639
66	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.68201083
67	meiotic chromosome segregation (GO:0045132)	2.67978001
68	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.66797905
69	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.66797905
70	C-terminal protein lipidation (GO:0006501)	2.66157034
71	mismatch repair (GO:0006298)	2.65583885
72	regulation of telomere maintenance (GO:0032204)	2.64288484
73	piRNA metabolic process (GO:0034587)	2.64273513
74	seminiferous tubule development (GO:0072520)	2.62790566
75	adenosine metabolic process (GO:0046085)	2.62395138
76	negative regulation of B cell apoptotic process (GO:0002903)	2.61900761
77	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.60970821
78	chaperone-mediated protein transport (GO:0072321)	2.59776375
79	electron transport chain (GO:0022900)	2.58256726
80	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.56765399
81	purine deoxyribonucleotide catabolic process (GO:0009155)	2.56531352
82	detection of light stimulus involved in sensory perception (GO:0050962)	2.54943615
83	detection of light stimulus involved in visual perception (GO:0050908)	2.54943615
84	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.54588587
85	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.53665025
86	autophagic vacuole fusion (GO:0000046)	2.53664907
87	respiratory electron transport chain (GO:0022904)	2.53573833
88	DNA modification (GO:0006304)	2.52860154
89	DNA catabolic process, exonucleolytic (GO:0000738)	2.52631464
90	ubiquinone metabolic process (GO:0006743)	2.50101930
91	rRNA catabolic process (GO:0016075)	2.48600866
92	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.48481505
93	termination of RNA polymerase III transcription (GO:0006386)	2.48481505
94	centriole assembly (GO:0098534)	2.47131163
95	C-terminal protein amino acid modification (GO:0018410)	2.46657600
96	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.43772088
97	DNA methylation involved in gamete generation (GO:0043046)	2.42662631
98	positive regulation of fatty acid transport (GO:2000193)	2.42560407
99	water-soluble vitamin biosynthetic process (GO:0042364)	2.42269892
100	sperm motility (GO:0030317)	2.41286629

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.08896360
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.57363108
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.17947631
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.15108275
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03383541
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.97653368
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.61082555
8	VDR_22108803_ChIP-Seq_LS180_Human	2.48465332
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.36066379
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.30487746
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.29867138
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28258958
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.20739836
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15811853
15	EWS_26573619_Chip-Seq_HEK293_Human	2.09981022
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.08171898
17	FUS_26573619_Chip-Seq_HEK293_Human	2.08113269
18	IGF1R_20145208_ChIP-Seq_DFB_Human	2.06768698
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.01655271
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.98199655
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.89217224
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.88471157
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.86483018
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.84608827
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.80191619
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.79996220
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79359888
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.77538345
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.76829574
30	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.73531108
31	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.72688187
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.72127849
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.69268073
34	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.66433648
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.64616623
36	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.61226052
37	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60109441
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50516855
39	TAF15_26573619_Chip-Seq_HEK293_Human	1.50091322
40	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.48896288
41	P300_19829295_ChIP-Seq_ESCs_Human	1.47355457
42	CIITA_25753668_ChIP-Seq_RAJI_Human	1.38018997
43	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.36694571
44	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.36516759
45	EZH2_22144423_ChIP-Seq_EOC_Human	1.34787726
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32199357
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.31946616
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31934737
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.30441191
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30441191
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.29182532
52	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.28006103
53	KDM5A_27292631_Chip-Seq_BREAST_Human	1.27734524
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26691590
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26691590
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24043404
57	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.23324539
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23311273
59	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.18929367
60	AR_20517297_ChIP-Seq_VCAP_Human	1.15235195
61	GABP_19822575_ChIP-Seq_HepG2_Human	1.13733847
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.10877759
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.09032421
64	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09032421
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.08784733
66	GATA3_26560356_Chip-Seq_TH2_Human	1.08341084
67	NCOR_22424771_ChIP-Seq_293T_Human	1.07599468
68	SCL_19346495_ChIP-Seq_HPC-7_Human	1.07444440
69	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.07149597
70	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06606021
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05162193
72	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04403721
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04113542
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04113542
75	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.03955098
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03766757
77	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.03635298
78	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.03034943
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01895627
80	ERA_21632823_ChIP-Seq_H3396_Human	1.01725252
81	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01623636
82	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00052329
83	BCAT_22108803_ChIP-Seq_LS180_Human	0.99707440
84	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98866646
85	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.95822013
86	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.94561714
87	STAT3_23295773_ChIP-Seq_U87_Human	0.94222200
88	TCF4_23295773_ChIP-Seq_U87_Human	0.94122304
89	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.93297113
90	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.91311887
91	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.90805211
92	AR_25329375_ChIP-Seq_VCAP_Human	0.90728023
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.90523844
94	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.89729990
95	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.89588195
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89269468
97	MYC_19829295_ChIP-Seq_ESCs_Human	0.88210584
98	P53_21459846_ChIP-Seq_SAOS-2_Human	0.87981939
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87965081
100	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.85942415

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	3.14647314
2	MP0008877_abnormal_DNA_methylation	2.88886247
3	MP0006292_abnormal_olfactory_placode	2.57551977
4	MP0000569_abnormal_digit_pigmentation	2.26756513
5	MP0002653_abnormal_ependyma_morphology	2.16943970
6	MP0005075_abnormal_melanosome_morpholog	2.14167003
7	MP0006072_abnormal_retinal_apoptosis	2.08153571
8	MP0010094_abnormal_chromosome_stability	2.04193037
9	MP0008872_abnormal_physiological_respon	2.03888334
10	MP0005084_abnormal_gallbladder_morpholo	2.03738581
11	MP0000372_irregular_coat_pigmentation	2.02290638
12	MP0003195_calcinosis	2.01731798
13	MP0008995_early_reproductive_senescence	2.01123719
14	MP0003718_maternal_effect	1.94931568
15	MP0003787_abnormal_imprinting	1.93676496
16	MP0002234_abnormal_pharynx_morphology	1.92427053
17	MP0005645_abnormal_hypothalamus_physiol	1.91599959
18	MP0005551_abnormal_eye_electrophysiolog	1.89441854
19	MP0004043_abnormal_pH_regulation	1.83645847
20	MP0002102_abnormal_ear_morphology	1.81285008
21	MP0003646_muscle_fatigue	1.80766936
22	MP0005646_abnormal_pituitary_gland	1.80122775
23	MP0004147_increased_porphyrin_level	1.79080347
24	MP0005410_abnormal_fertilization	1.70482461
25	MP0001968_abnormal_touch/_nociception	1.64541072
26	MP0008875_abnormal_xenobiotic_pharmacok	1.59221812
27	MP0002396_abnormal_hematopoietic_system	1.57668217
28	MP0002837_dystrophic_cardiac_calcinosis	1.56824557
29	MP0001986_abnormal_taste_sensitivity	1.54929602
30	MP0005253_abnormal_eye_physiology	1.54261811
31	MP0003786_premature_aging	1.48016193
32	MP0006036_abnormal_mitochondrial_physio	1.40408093
33	MP0008057_abnormal_DNA_replication	1.40341225
34	MP0002876_abnormal_thyroid_physiology	1.37365860
35	MP0002095_abnormal_skin_pigmentation	1.33754465
36	MP0009046_muscle_twitch	1.31384398
37	MP0002938_white_spotting	1.31243408
38	MP0004142_abnormal_muscle_tone	1.28343294
39	MP0005174_abnormal_tail_pigmentation	1.27533011
40	MP0001929_abnormal_gametogenesis	1.27512824
41	MP0002736_abnormal_nociception_after	1.27493897
42	MP0005220_abnormal_exocrine_pancreas	1.26286409
43	MP0002928_abnormal_bile_duct	1.25939335
44	MP0003136_yellow_coat_color	1.25581466
45	MP0002638_abnormal_pupillary_reflex	1.24535281
46	MP0001764_abnormal_homeostasis	1.23042925
47	MP0003698_abnormal_male_reproductive	1.22727384
48	MP0003806_abnormal_nucleotide_metabolis	1.22323604
49	MP0000631_abnormal_neuroendocrine_gland	1.22036289
50	MP0003011_delayed_dark_adaptation	1.11260714
51	MP0000427_abnormal_hair_cycle	1.09508244
52	MP0000015_abnormal_ear_pigmentation	1.08314473
53	MP0001873_stomach_inflammation	1.03181265
54	MP0002160_abnormal_reproductive_system	1.00937348
55	MP0009745_abnormal_behavioral_response	0.99402053
56	MP0001501_abnormal_sleep_pattern	0.98060489
57	MP0002735_abnormal_chemical_nociception	0.97800909
58	MP0006276_abnormal_autonomic_nervous	0.97459601
59	MP0001905_abnormal_dopamine_level	0.96765760
60	MP0001529_abnormal_vocalization	0.95775306
61	MP0000465_gastrointestinal_hemorrhage	0.95296083
62	MP0002210_abnormal_sex_determination	0.94794473
63	MP0001485_abnormal_pinna_reflex	0.90824117
64	MP0002693_abnormal_pancreas_physiology	0.90681798
65	MP0006035_abnormal_mitochondrial_morpho	0.90115328
66	MP0002751_abnormal_autonomic_nervous	0.89943864
67	MP0009697_abnormal_copulation	0.89704500
68	MP0005389_reproductive_system_phenotype	0.87493796
69	MP0008961_abnormal_basal_metabolism	0.87191107
70	MP0008775_abnormal_heart_ventricle	0.87062683
71	MP0000653_abnormal_sex_gland	0.86666702
72	MP0002272_abnormal_nervous_system	0.85533017
73	MP0010386_abnormal_urinary_bladder	0.85064548
74	MP0001145_abnormal_male_reproductive	0.84911134
75	MP0000383_abnormal_hair_follicle	0.82709704
76	MP0005083_abnormal_biliary_tract	0.80417007
77	MP0001984_abnormal_olfaction	0.79954348
78	MP0001486_abnormal_startle_reflex	0.77714335
79	MP0001545_abnormal_hematopoietic_system	0.77588109
80	MP0005397_hematopoietic_system_phenotyp	0.77588109
81	MP0005670_abnormal_white_adipose	0.77302307
82	MP0004133_heterotaxia	0.76930219
83	MP0005266_abnormal_metabolism	0.75902687
84	MP0003121_genomic_imprinting	0.74997885
85	MP0008007_abnormal_cellular_replicative	0.74757080
86	MP0003252_abnormal_bile_duct	0.74567739
87	MP0002733_abnormal_thermal_nociception	0.72252865
88	MP0002132_abnormal_respiratory_system	0.71683094
89	MP0005332_abnormal_amino_acid	0.71585815
90	MP0003186_abnormal_redox_activity	0.67999987
91	MP0004885_abnormal_endolymph	0.67690045
92	MP0008789_abnormal_olfactory_epithelium	0.67072720
93	MP0004924_abnormal_behavior	0.66973437
94	MP0005386_behavior/neurological_phenoty	0.66973437
95	MP0000689_abnormal_spleen_morphology	0.66760734
96	MP0003111_abnormal_nucleus_morphology	0.66710450
97	MP0004145_abnormal_muscle_electrophysio	0.66568291
98	MP0002572_abnormal_emotion/affect_behav	0.66543821
99	MP0000230_abnormal_systemic_arterial	0.66313600
100	MP0002557_abnormal_social/conspecific_i	0.65866076

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.85951232
2	Molar tooth sign on MRI (HP:0002419)	3.43092515
3	Abnormality of midbrain morphology (HP:0002418)	3.43092515
4	Pancreatic fibrosis (HP:0100732)	3.39990594
5	Nephronophthisis (HP:0000090)	3.33148673
6	Mitochondrial inheritance (HP:0001427)	3.32277648
7	True hermaphroditism (HP:0010459)	3.19203635
8	Acute necrotizing encephalopathy (HP:0006965)	3.16934111
9	Increased CSF lactate (HP:0002490)	3.06578095
10	Hepatocellular necrosis (HP:0001404)	2.97362625
11	Abnormality of the renal cortex (HP:0011035)	2.95861318
12	Congenital stationary night blindness (HP:0007642)	2.94712619
13	Abnormality of the renal medulla (HP:0100957)	2.92279041
14	Type II lissencephaly (HP:0007260)	2.90570210
15	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89563344
16	Attenuation of retinal blood vessels (HP:0007843)	2.81569842
17	Medial flaring of the eyebrow (HP:0010747)	2.81244147
18	Acute encephalopathy (HP:0006846)	2.80149117
19	Hepatic necrosis (HP:0002605)	2.75026216
20	Progressive macrocephaly (HP:0004481)	2.73199720
21	Renal cortical cysts (HP:0000803)	2.54650387
22	Cerebellar dysplasia (HP:0007033)	2.53003158
23	Abnormal number of erythroid precursors (HP:0012131)	2.52809388
24	Stomach cancer (HP:0012126)	2.50123708
25	Panhypogammaglobulinemia (HP:0003139)	2.48035333
26	Birth length less than 3rd percentile (HP:0003561)	2.47632553
27	Lipid accumulation in hepatocytes (HP:0006561)	2.36294254
28	Chronic hepatic failure (HP:0100626)	2.35673056
29	Cystic liver disease (HP:0006706)	2.35660133
30	Polydipsia (HP:0001959)	2.34504243
31	Abnormal drinking behavior (HP:0030082)	2.34504243
32	3-Methylglutaconic aciduria (HP:0003535)	2.32083031
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.25958172
34	Increased hepatocellular lipid droplets (HP:0006565)	2.25542207
35	Gaze-evoked nystagmus (HP:0000640)	2.25511453
36	Severe combined immunodeficiency (HP:0004430)	2.25349474
37	Abnormality of B cell number (HP:0010975)	2.23925955
38	Tubulointerstitial nephritis (HP:0001970)	2.23916919
39	Methylmalonic acidemia (HP:0002912)	2.21849329
40	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.21750549
41	Ketoacidosis (HP:0001993)	2.21427989
42	Ketosis (HP:0001946)	2.19623390
43	Renal Fanconi syndrome (HP:0001994)	2.18184971
44	Congenital, generalized hypertrichosis (HP:0004540)	2.16528122
45	Increased serum lactate (HP:0002151)	2.14193500
46	Progressive microcephaly (HP:0000253)	2.13888357
47	Optic disc pallor (HP:0000543)	2.12143701
48	Lactic acidosis (HP:0003128)	2.10957992
49	Abolished electroretinogram (ERG) (HP:0000550)	2.10061833
50	Cerebral edema (HP:0002181)	2.09495312
51	Hyperventilation (HP:0002883)	2.08197060
52	Acute lymphatic leukemia (HP:0006721)	2.07610269
53	Agammaglobulinemia (HP:0004432)	2.05478178
54	Inability to walk (HP:0002540)	2.05274286
55	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.04553483
56	Methylmalonic aciduria (HP:0012120)	2.03638275
57	Large for gestational age (HP:0001520)	2.03586668
58	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.95979725
59	Congenital primary aphakia (HP:0007707)	1.95164776
60	Gait imbalance (HP:0002141)	1.94639106
61	Abnormality of cells of the erythroid lineage (HP:0012130)	1.93474692
62	Polyuria (HP:0000103)	1.93427146
63	Thyroiditis (HP:0100646)	1.93381683
64	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.92494672
65	Constricted visual fields (HP:0001133)	1.92284731
66	Tubular atrophy (HP:0000092)	1.90227023
67	Colon cancer (HP:0003003)	1.88487941
68	Bile duct proliferation (HP:0001408)	1.87950498
69	Abnormal biliary tract physiology (HP:0012439)	1.87950498
70	B lymphocytopenia (HP:0010976)	1.87900432
71	Type I transferrin isoform profile (HP:0003642)	1.87601272
72	Patellar aplasia (HP:0006443)	1.87562734
73	Progressive inability to walk (HP:0002505)	1.87131747
74	Hypothermia (HP:0002045)	1.86554443
75	Congenital hepatic fibrosis (HP:0002612)	1.84659129
76	Lissencephaly (HP:0001339)	1.83364461
77	Abnormality of DNA repair (HP:0003254)	1.82848967
78	Nephrogenic diabetes insipidus (HP:0009806)	1.82654507
79	Pendular nystagmus (HP:0012043)	1.82377155
80	Decreased central vision (HP:0007663)	1.81717215
81	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.79712371
82	Abnormal protein N-linked glycosylation (HP:0012347)	1.79712371
83	Abnormal protein glycosylation (HP:0012346)	1.79712371
84	Abnormal glycosylation (HP:0012345)	1.79712371
85	Abnormality of renal resorption (HP:0011038)	1.79200456
86	Clubbing of toes (HP:0100760)	1.78641234
87	Lethargy (HP:0001254)	1.78333821
88	Hypomagnesemia (HP:0002917)	1.78063892
89	Aplasia/Hypoplasia of the patella (HP:0006498)	1.77614886
90	Meckel diverticulum (HP:0002245)	1.77183222
91	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.76995589
92	Dicarboxylic aciduria (HP:0003215)	1.76995589
93	Increased intramyocellular lipid droplets (HP:0012240)	1.76738011
94	Abnormality of the ileum (HP:0001549)	1.76547824
95	Autoimmune hemolytic anemia (HP:0001890)	1.75980936
96	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.75332857
97	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.75332857
98	Duplicated collecting system (HP:0000081)	1.75255940
99	Thyroid-stimulating hormone excess (HP:0002925)	1.74796787
100	Absent thumb (HP:0009777)	1.74595417

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.39981682
2	TAOK3	3.41686611
3	TLK1	3.37689209
4	VRK2	3.08454858
5	INSRR	3.05315913
6	MAP4K2	3.02343613
7	NUAK1	2.93354196
8	KIT	2.44696809
9	ZAK	2.36441765
10	BMPR1B	2.29274082
11	WNK3	2.16517483
12	ADRBK2	2.08255560
13	BCKDK	1.90490105
14	VRK1	1.80224367
15	MAPK13	1.67040836
16	FLT3	1.63570456
17	MAPK15	1.60906581
18	GRK1	1.43150005
19	PIK3CA	1.42956361
20	PLK4	1.39728933
21	OXSR1	1.36805168
22	MAP2K6	1.26749004
23	TEC	1.21667518
24	MAPKAPK3	1.21148343
25	NME1	1.18357787
26	PNCK	1.17785444
27	TNK2	1.14453719
28	NEK2	1.12254878
29	CCNB1	1.11884132
30	WNK4	1.11251214
31	MKNK2	1.09995065
32	IKBKB	0.99844958
33	PINK1	0.98198483
34	MAP3K4	0.95798508
35	CDC7	0.94913257
36	TRIM28	0.92091659
37	ATR	0.91935908
38	MAPKAPK5	0.88569086
39	SRPK1	0.87967588
40	MAP4K1	0.87042908
41	PHKG2	0.79502805
42	PHKG1	0.79502805
43	MKNK1	0.78628218
44	SYK	0.78183590
45	BRSK2	0.76058701
46	ACVR1B	0.75970093
47	KDR	0.75036608
48	PDK2	0.73963545
49	TAF1	0.73660610
50	ADRBK1	0.71346942
51	TNIK	0.71326493
52	WEE1	0.69364582
53	STK16	0.69089545
54	PIK3CG	0.67791533
55	CAMKK2	0.67219312
56	CSF1R	0.66998623
57	TXK	0.66737155
58	CDK19	0.65872885
59	NEK1	0.63830364
60	PRKCG	0.63723524
61	CDK3	0.60783381
62	CHEK2	0.60394181
63	DYRK2	0.60106831
64	GRK6	0.57530716
65	RPS6KA5	0.55794351
66	PTK2B	0.55444175
67	BTK	0.53221740
68	TGFBR1	0.53203487
69	STK39	0.52243304
70	PLK3	0.49553391
71	MUSK	0.49551106
72	ITK	0.49171119
73	CDK8	0.49114173
74	PRKCQ	0.48747465
75	BMPR2	0.48477317
76	ATM	0.47583181
77	PKN1	0.47122296
78	CSNK1G3	0.46601363
79	LYN	0.46419992
80	PAK3	0.46102425
81	MAP2K7	0.45000251
82	CAMK1	0.44920462
83	MAP2K2	0.43918671
84	FES	0.43917178
85	MST4	0.43817681
86	CSNK1G1	0.43567140
87	OBSCN	0.42969168
88	CSNK1A1	0.41989854
89	IKBKE	0.41123358
90	MAP2K4	0.41068599
91	CSNK1D	0.39046345
92	PRKCE	0.38494577
93	EIF2AK2	0.37675467
94	PLK2	0.37120093
95	PLK1	0.36497415
96	LCK	0.35360399
97	IGF1R	0.35203557
98	CASK	0.34400782
99	MARK3	0.34296253
100	PBK	0.32902000

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.44275060
2	RNA polymerase_Homo sapiens_hsa03020	2.92025597
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.91383564
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.79111027
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.69420894
6	Parkinsons disease_Homo sapiens_hsa05012	2.24108227
7	Butanoate metabolism_Homo sapiens_hsa00650	2.22655955
8	Phototransduction_Homo sapiens_hsa04744	2.07115519
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.05805181
10	Base excision repair_Homo sapiens_hsa03410	2.03353541
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.90870393
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.88329113
13	Proteasome_Homo sapiens_hsa03050	1.86155450
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.81328768
15	Mismatch repair_Homo sapiens_hsa03430	1.80132922
16	Basal transcription factors_Homo sapiens_hsa03022	1.78325621
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.75719080
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.75002606
19	Ribosome_Homo sapiens_hsa03010	1.73775575
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.72228107
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.70477534
22	RNA degradation_Homo sapiens_hsa03018	1.70048505
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.66116181
24	DNA replication_Homo sapiens_hsa03030	1.66055822
25	One carbon pool by folate_Homo sapiens_hsa00670	1.64292270
26	Protein export_Homo sapiens_hsa03060	1.64022705
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.62165934
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60806609
29	Huntingtons disease_Homo sapiens_hsa05016	1.59988971
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.55767907
31	Caffeine metabolism_Homo sapiens_hsa00232	1.54161420
32	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.44877680
33	Propanoate metabolism_Homo sapiens_hsa00640	1.42131396
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.40185078
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39978468
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39523285
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.38726557
38	Peroxisome_Homo sapiens_hsa04146	1.38672171
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.36221489
40	Purine metabolism_Homo sapiens_hsa00230	1.34062193
41	Spliceosome_Homo sapiens_hsa03040	1.33720003
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.33603596
43	Asthma_Homo sapiens_hsa05310	1.29258221
44	Alzheimers disease_Homo sapiens_hsa05010	1.27875194
45	RNA transport_Homo sapiens_hsa03013	1.21605548
46	Taste transduction_Homo sapiens_hsa04742	1.17801506
47	Selenocompound metabolism_Homo sapiens_hsa00450	1.17435845
48	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.12001741
49	Type I diabetes mellitus_Homo sapiens_hsa04940	1.04922635
50	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.02746543
51	Olfactory transduction_Homo sapiens_hsa04740	0.97403149
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.95310832
53	Nicotine addiction_Homo sapiens_hsa05033	0.92863635
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91054951
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.90721978
56	Regulation of autophagy_Homo sapiens_hsa04140	0.90647240
57	Allograft rejection_Homo sapiens_hsa05330	0.89454089
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.86710707
59	Graft-versus-host disease_Homo sapiens_hsa05332	0.84462567
60	Fatty acid elongation_Homo sapiens_hsa00062	0.82455048
61	ABC transporters_Homo sapiens_hsa02010	0.80825138
62	Cardiac muscle contraction_Homo sapiens_hsa04260	0.80068703
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74253407
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71339838
65	Metabolic pathways_Homo sapiens_hsa01100	0.68300759
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64879129
67	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.60394358
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.60246576
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59983044
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.59497076
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55221825
72	Retinol metabolism_Homo sapiens_hsa00830	0.54885873
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54580497
74	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.53153245
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52446486
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50810156
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.49221640
78	Sulfur metabolism_Homo sapiens_hsa00920	0.47708523
79	Salivary secretion_Homo sapiens_hsa04970	0.46496587
80	Fatty acid degradation_Homo sapiens_hsa00071	0.43360247
81	Morphine addiction_Homo sapiens_hsa05032	0.40938643
82	Sulfur relay system_Homo sapiens_hsa04122	0.39744255
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.38564613
84	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.38427087
85	Lysine degradation_Homo sapiens_hsa00310	0.37542241
86	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.33718723
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.32879071
88	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.32357311
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32272731
90	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.30725936
91	Circadian entrainment_Homo sapiens_hsa04713	0.30411558
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.29863826
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29071751
94	Insulin secretion_Homo sapiens_hsa04911	0.28636330
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.26228223
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25960960
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.24735467
98	Glutathione metabolism_Homo sapiens_hsa00480	0.24454130
99	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.23744197
100	Rheumatoid arthritis_Homo sapiens_hsa05323	0.21793619

STAG3L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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