STAG3L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.74129137
2centriole replication (GO:0007099)4.68419032
3base-excision repair, AP site formation (GO:0006285)4.65057548
4purine deoxyribonucleotide catabolic process (GO:0009155)4.60716868
5negative regulation of B cell apoptotic process (GO:0002903)4.39090556
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.89309209
7deoxyribonucleotide catabolic process (GO:0009264)3.76217202
8protoporphyrinogen IX biosynthetic process (GO:0006782)3.72696641
9autophagic vacuole fusion (GO:0000046)3.71790172
10L-fucose catabolic process (GO:0042355)3.66753838
11fucose catabolic process (GO:0019317)3.66753838
12L-fucose metabolic process (GO:0042354)3.66753838
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66507622
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.66507622
15NADH dehydrogenase complex assembly (GO:0010257)3.66507622
16protein complex biogenesis (GO:0070271)3.64540128
17cellular response to exogenous dsRNA (GO:0071360)3.63164480
18mannosylation (GO:0097502)3.60543908
19seminiferous tubule development (GO:0072520)3.58426831
20purine deoxyribonucleotide metabolic process (GO:0009151)3.50865313
21mitochondrial respiratory chain complex assembly (GO:0033108)3.44645050
22deoxyribose phosphate catabolic process (GO:0046386)3.43655508
23negative regulation of telomere maintenance (GO:0032205)3.43575479
24cytochrome complex assembly (GO:0017004)3.42722921
25respiratory chain complex IV assembly (GO:0008535)3.42270942
26preassembly of GPI anchor in ER membrane (GO:0016254)3.41334170
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.38765431
28positive regulation of B cell differentiation (GO:0045579)3.37510900
29positive regulation of granulocyte differentiation (GO:0030854)3.33439181
30negative regulation of cell cycle arrest (GO:0071157)3.31982648
31centriole assembly (GO:0098534)3.22028401
32response to misfolded protein (GO:0051788)3.21414504
33positive regulation of prostaglandin secretion (GO:0032308)3.21248251
34regulation of B cell apoptotic process (GO:0002902)3.19319449
35positive regulation of histone deacetylation (GO:0031065)3.10040091
36reciprocal meiotic recombination (GO:0007131)3.09611063
37reciprocal DNA recombination (GO:0035825)3.09611063
38purinergic nucleotide receptor signaling pathway (GO:0035590)3.05078685
39cellular extravasation (GO:0045123)3.03120496
40ubiquinone biosynthetic process (GO:0006744)2.99637807
41DNA double-strand break processing (GO:0000729)2.95160113
42protoporphyrinogen IX metabolic process (GO:0046501)2.92075575
43response to pheromone (GO:0019236)2.89900621
44organelle membrane fusion (GO:0090174)2.89498943
45tryptophan metabolic process (GO:0006568)2.85682941
46regulation of MHC class II biosynthetic process (GO:0045346)2.83807001
47positive regulation of defense response to virus by host (GO:0002230)2.82695209
482-deoxyribonucleotide metabolic process (GO:0009394)2.82274475
49pyrimidine nucleotide catabolic process (GO:0006244)2.81939547
50DNA modification (GO:0006304)2.81100953
51purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.79914339
52double-strand break repair via homologous recombination (GO:0000724)2.79111465
53replication fork processing (GO:0031297)2.77911542
54histone H3-K9 methylation (GO:0051567)2.77342484
55phosphatidylglycerol biosynthetic process (GO:0006655)2.77192139
56recombinational repair (GO:0000725)2.77060858
57pseudouridine synthesis (GO:0001522)2.76342951
58peptidyl-histidine modification (GO:0018202)2.74965723
59NAD biosynthetic process (GO:0009435)2.74348368
60behavioral response to nicotine (GO:0035095)2.74229369
61positive regulation of icosanoid secretion (GO:0032305)2.73094094
62positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.72825234
63regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.72825234
64tryptophan catabolic process (GO:0006569)2.72664670
65indole-containing compound catabolic process (GO:0042436)2.72664670
66indolalkylamine catabolic process (GO:0046218)2.72664670
67mast cell activation involved in immune response (GO:0002279)2.72032337
68mast cell degranulation (GO:0043303)2.72032337
69metallo-sulfur cluster assembly (GO:0031163)2.71910505
70iron-sulfur cluster assembly (GO:0016226)2.71910505
71definitive hemopoiesis (GO:0060216)2.70650248
72indolalkylamine metabolic process (GO:0006586)2.68079398
73positive regulation of fatty acid transport (GO:2000193)2.67892740
74regulation of telomere maintenance (GO:0032204)2.66753453
75misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.65898919
76Peyers patch development (GO:0048541)2.65147869
77mucosal-associated lymphoid tissue development (GO:0048537)2.65147869
78DNA demethylation (GO:0080111)2.65072956
79rRNA modification (GO:0000154)2.62017523
80RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61454200
81DNA dealkylation (GO:0035510)2.60419977
82mitochondrial RNA metabolic process (GO:0000959)2.59740463
83deoxyribose phosphate metabolic process (GO:0019692)2.53510941
84ubiquinone metabolic process (GO:0006743)2.52548201
85DNA catabolic process, endonucleolytic (GO:0000737)2.52531007
86positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.51537319
87deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.51261943
88positive regulation of protein deacetylation (GO:0090312)2.51023558
89reactive oxygen species biosynthetic process (GO:1903409)2.50593791
90tRNA modification (GO:0006400)2.50398143
91response to interferon-beta (GO:0035456)2.49109400
92DNA integration (GO:0015074)2.49015622
93regulation of gamma-delta T cell differentiation (GO:0045586)2.48580676
94aggressive behavior (GO:0002118)2.48065309
95somatic diversification of immunoglobulins (GO:0016445)2.45812901
96GPI anchor metabolic process (GO:0006505)2.45120797
97positive regulation of mRNA catabolic process (GO:0061014)2.44427974
98regulation of B cell differentiation (GO:0045577)2.44235087
99cellular response to dsRNA (GO:0071359)2.43956728
100axoneme assembly (GO:0035082)2.43764725

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.61053633
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.59669560
3ZNF274_21170338_ChIP-Seq_K562_Hela3.50829938
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.22627974
5SCL_19346495_ChIP-Seq_HPC-7_Human3.16823016
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66618559
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64568608
8VDR_23849224_ChIP-Seq_CD4+_Human2.24928537
9SRF_21415370_ChIP-Seq_HL-1_Mouse2.24281060
10IGF1R_20145208_ChIP-Seq_DFB_Human2.23688631
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.19250760
12CIITA_25753668_ChIP-Seq_RAJI_Human2.17335284
13LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.17116402
14FOXP3_21729870_ChIP-Seq_TREG_Human2.15882385
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12821845
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.10691330
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06378625
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.05578723
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95602207
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.88991571
21KDM5A_27292631_Chip-Seq_BREAST_Human1.82886374
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81930897
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74249982
24IRF1_19129219_ChIP-ChIP_H3396_Human1.71606590
25EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71303641
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63845793
27MYB_26560356_Chip-Seq_TH2_Human1.63212947
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61929455
29VDR_22108803_ChIP-Seq_LS180_Human1.60850739
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60336397
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50681946
32MYC_18940864_ChIP-ChIP_HL60_Human1.49713809
33* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.49701948
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49390930
35GABP_19822575_ChIP-Seq_HepG2_Human1.47701163
36BCL6_27268052_Chip-Seq_Bcells_Human1.43673018
37TP53_22573176_ChIP-Seq_HFKS_Human1.41238091
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40419463
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.39628529
40ER_23166858_ChIP-Seq_MCF-7_Human1.39046912
41FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38961379
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37507543
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.37261752
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37148748
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36217952
46VDR_21846776_ChIP-Seq_THP-1_Human1.35590541
47GATA3_26560356_Chip-Seq_TH2_Human1.35286658
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35049971
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.34264283
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30645966
51CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.29371756
52E2F1_20622854_ChIP-Seq_HELA_Human1.26214990
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25909408
54MYB_26560356_Chip-Seq_TH1_Human1.25800136
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25576417
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24649238
57P300_27268052_Chip-Seq_Bcells_Human1.24463390
58ERA_21632823_ChIP-Seq_H3396_Human1.24310226
59SPI1_23547873_ChIP-Seq_NB4_Human1.24108405
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.23706430
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.22317792
62RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21635436
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20072822
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19649113
65GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19511519
66GATA3_27048872_Chip-Seq_THYMUS_Human1.19273265
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18400327
68GATA3_21878914_ChIP-Seq_MCF-7_Human1.17302613
69E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16843038
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14065707
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13321624
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12423178
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11749515
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11195967
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10954028
76NANOG_20526341_ChIP-Seq_ESCs_Human1.10290074
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09417012
78RUNX_20019798_ChIP-Seq_JUKART_Human1.09192512
79E2F7_22180533_ChIP-Seq_HELA_Human1.09067064
80* RAC3_21632823_ChIP-Seq_H3396_Human1.07681511
81BP1_19119308_ChIP-ChIP_Hs578T_Human1.07155631
82AR_20517297_ChIP-Seq_VCAP_Human1.06974054
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06276315
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.05480223
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.05412137
86EWS_26573619_Chip-Seq_HEK293_Human1.04451831
87ELK1_19687146_ChIP-ChIP_HELA_Human1.04447852
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.03625814
89P53_21459846_ChIP-Seq_SAOS-2_Human1.03606193
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02487269
91PHF8_20622854_ChIP-Seq_HELA_Human1.01838337
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01353799
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99182232
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98700838
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98616071
96BCOR_27268052_Chip-Seq_Bcells_Human0.98480457
97UTX_26944678_Chip-Seq_JUKART_Human0.98142474
98OCT4_20526341_ChIP-Seq_ESCs_Human0.97881728
99TAF2_19829295_ChIP-Seq_ESCs_Human0.97532066
100HOXB7_26014856_ChIP-Seq_BT474_Human0.97044139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.81251457
2MP0005083_abnormal_biliary_tract3.01243608
3MP0004043_abnormal_pH_regulation2.61197751
4MP0002396_abnormal_hematopoietic_system2.58157838
5MP0001545_abnormal_hematopoietic_system2.24922943
6MP0005397_hematopoietic_system_phenotyp2.24922943
7MP0005075_abnormal_melanosome_morpholog2.18491246
8MP0008057_abnormal_DNA_replication2.17825926
9MP0008872_abnormal_physiological_respon2.14491312
10MP0010094_abnormal_chromosome_stability2.13602615
11MP0009278_abnormal_bone_marrow2.13117955
12MP0008877_abnormal_DNA_methylation2.11245244
13MP0000372_irregular_coat_pigmentation2.07184605
14MP0001873_stomach_inflammation2.06186201
15MP0000465_gastrointestinal_hemorrhage1.97193355
16MP0005670_abnormal_white_adipose1.92211325
17MP0008995_early_reproductive_senescence1.91784035
18MP0003786_premature_aging1.90972771
19MP0001835_abnormal_antigen_presentation1.89990570
20MP0008961_abnormal_basal_metabolism1.83070126
21MP0003763_abnormal_thymus_physiology1.79904885
22MP0004147_increased_porphyrin_level1.76734964
23MP0003646_muscle_fatigue1.70667763
24MP0003806_abnormal_nucleotide_metabolis1.69791488
25MP0005645_abnormal_hypothalamus_physiol1.65445213
26MP0003718_maternal_effect1.60738638
27MP0003195_calcinosis1.55487012
28MP0008875_abnormal_xenobiotic_pharmacok1.55387805
29MP0003252_abnormal_bile_duct1.54232694
30MP0005646_abnormal_pituitary_gland1.51677879
31MP0001986_abnormal_taste_sensitivity1.50877121
32MP0005551_abnormal_eye_electrophysiolog1.49868746
33MP0006036_abnormal_mitochondrial_physio1.47245847
34MP0003787_abnormal_imprinting1.45864808
35MP0001800_abnormal_humoral_immune1.41236748
36MP0001968_abnormal_touch/_nociception1.39856295
37MP0002234_abnormal_pharynx_morphology1.37312310
38MP0002398_abnormal_bone_marrow1.32125458
39MP0008007_abnormal_cellular_replicative1.31566033
40MP0005410_abnormal_fertilization1.30019382
41MP0000689_abnormal_spleen_morphology1.28141732
42MP0002420_abnormal_adaptive_immunity1.25942273
43MP0000015_abnormal_ear_pigmentation1.23707663
44MP0001819_abnormal_immune_cell1.23104350
45MP0005174_abnormal_tail_pigmentation1.21088199
46MP0001764_abnormal_homeostasis1.20469928
47MP0002019_abnormal_tumor_incidence1.19853067
48MP0002822_catalepsy1.16238286
49MP0000716_abnormal_immune_system1.14607834
50MP0000569_abnormal_digit_pigmentation1.13868639
51MP0002132_abnormal_respiratory_system1.13060986
52MP0002722_abnormal_immune_system1.12911014
53MP0002452_abnormal_antigen_presenting1.12728702
54MP0002723_abnormal_immune_serum1.09659317
55MP0005671_abnormal_response_to1.09403366
56MP0004808_abnormal_hematopoietic_stem1.09291416
57MP0006292_abnormal_olfactory_placode1.06789479
58MP0005220_abnormal_exocrine_pancreas1.05454371
59MP0002148_abnormal_hypersensitivity_rea1.02345712
60MP0002429_abnormal_blood_cell1.02158620
61MP0002095_abnormal_skin_pigmentation1.01937474
62MP0005085_abnormal_gallbladder_physiolo1.01451997
63MP0001929_abnormal_gametogenesis0.99964261
64MP0009697_abnormal_copulation0.99098621
65MP0005025_abnormal_response_to0.98512663
66MP0003698_abnormal_male_reproductive0.98364825
67MP0000703_abnormal_thymus_morphology0.98262315
68MP0006035_abnormal_mitochondrial_morpho0.96760866
69MP0005367_renal/urinary_system_phenotyp0.96014340
70MP0000516_abnormal_urinary_system0.96014340
71MP0005464_abnormal_platelet_physiology0.95215722
72MP0005266_abnormal_metabolism0.95085110
73MP0001501_abnormal_sleep_pattern0.95014585
74MP0002653_abnormal_ependyma_morphology0.94035854
75MP0001529_abnormal_vocalization0.92910667
76MP0002419_abnormal_innate_immunity0.91782605
77MP0005000_abnormal_immune_tolerance0.91293272
78MP0009764_decreased_sensitivity_to0.90529618
79MP0002736_abnormal_nociception_after0.88767677
80MP0003943_abnormal_hepatobiliary_system0.88362574
81MP0005365_abnormal_bile_salt0.87719471
82MP0004142_abnormal_muscle_tone0.87522141
83MP0003111_abnormal_nucleus_morphology0.85649022
84MP0005084_abnormal_gallbladder_morpholo0.84986300
85MP0002970_abnormal_white_adipose0.84313697
86MP0009765_abnormal_xenobiotic_induced0.81804825
87MP0003436_decreased_susceptibility_to0.80617497
88MP0008873_increased_physiological_sensi0.80321753
89MP0002735_abnormal_chemical_nociception0.80144138
90MP0001905_abnormal_dopamine_level0.78210388
91MP0002876_abnormal_thyroid_physiology0.77442534
92MP0002160_abnormal_reproductive_system0.74658637
93MP0002405_respiratory_system_inflammati0.73546084
94MP0006276_abnormal_autonomic_nervous0.73111045
95MP0006072_abnormal_retinal_apoptosis0.72590328
96MP0005253_abnormal_eye_physiology0.70509084
97MP0008775_abnormal_heart_ventricle0.68902658
98MP0000230_abnormal_systemic_arterial0.68294723
99MP0000653_abnormal_sex_gland0.67584764
100MP0009643_abnormal_urine_homeostasis0.67318741

Predicted human phenotypes

RankGene SetZ-score
1Agammaglobulinemia (HP:0004432)3.74218870
2Abnormal delayed hypersensitivity skin test (HP:0002963)3.50045467
3Panhypogammaglobulinemia (HP:0003139)3.39763443
4Tubulointerstitial nephritis (HP:0001970)3.30773735
5Autoimmune thrombocytopenia (HP:0001973)3.26829239
6Hepatocellular necrosis (HP:0001404)3.08862738
7Progressive microcephaly (HP:0000253)2.98866846
8Granulocytopenia (HP:0001913)2.97658138
9Abnormality of B cell number (HP:0010975)2.96812007
10Severe combined immunodeficiency (HP:0004430)2.94240217
11Autoimmune hemolytic anemia (HP:0001890)2.91070932
12Decreased electroretinogram (ERG) amplitude (HP:0000654)2.86404575
13Nephronophthisis (HP:0000090)2.84601763
14Pancreatic cysts (HP:0001737)2.80403697
15Eosinophilia (HP:0001880)2.80315540
16Abnormality of midbrain morphology (HP:0002418)2.78112454
17Molar tooth sign on MRI (HP:0002419)2.78112454
18Acute lymphatic leukemia (HP:0006721)2.77218143
19Abnormality of T cell physiology (HP:0011840)2.75611258
20Attenuation of retinal blood vessels (HP:0007843)2.72610723
21Cerebellar dysplasia (HP:0007033)2.71469850
22Abnormality of the prostate (HP:0008775)2.71407850
23Elevated erythrocyte sedimentation rate (HP:0003565)2.69856836
24Abnormality of the renal medulla (HP:0100957)2.69669848
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69657709
26Chromsome breakage (HP:0040012)2.65274160
27Mitochondrial inheritance (HP:0001427)2.65135867
28Abnormality of the renal cortex (HP:0011035)2.64902331
29Hepatic necrosis (HP:0002605)2.64426603
30Microvesicular hepatic steatosis (HP:0001414)2.63573435
31Abnormality of eosinophils (HP:0001879)2.54973629
32B lymphocytopenia (HP:0010976)2.54026672
33Type II lissencephaly (HP:0007260)2.53889016
34Increased CSF lactate (HP:0002490)2.50121888
35Abnormal glycosylation (HP:0012345)2.49920688
36Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.49920688
37Abnormal protein N-linked glycosylation (HP:0012347)2.49920688
38Abnormal protein glycosylation (HP:0012346)2.49920688
39Congenital stationary night blindness (HP:0007642)2.48010369
40Type I transferrin isoform profile (HP:0003642)2.42620840
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.38923512
42Birth length less than 3rd percentile (HP:0003561)2.38422119
43Medial flaring of the eyebrow (HP:0010747)2.33583010
44Stomach cancer (HP:0012126)2.30410879
45Thrombocytosis (HP:0001894)2.30022938
46Pancreatic fibrosis (HP:0100732)2.28430333
47Renal cortical cysts (HP:0000803)2.24440587
48Gaze-evoked nystagmus (HP:0000640)2.24328453
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.22839858
50Clubbing of toes (HP:0100760)2.19529399
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16326644
52Dicarboxylic aciduria (HP:0003215)2.16326644
53Abnormal mitochondria in muscle tissue (HP:0008316)2.14262187
54Neutropenia (HP:0001875)2.12675992
55Stomatitis (HP:0010280)2.12528711
56Abnormality of T cells (HP:0002843)2.10113755
57Recurrent fungal infections (HP:0002841)2.08701356
58True hermaphroditism (HP:0010459)2.07345785
59Prostate neoplasm (HP:0100787)2.05676670
60Thyroiditis (HP:0100646)2.05192925
61Increased intramyocellular lipid droplets (HP:0012240)2.03098055
62Abolished electroretinogram (ERG) (HP:0000550)2.02346753
63Combined immunodeficiency (HP:0005387)2.01767385
64Retinal dysplasia (HP:0007973)2.01493569
65Increased muscle lipid content (HP:0009058)2.00322520
66Cerebral palsy (HP:0100021)1.98668310
67Ketosis (HP:0001946)1.96944026
68Acute necrotizing encephalopathy (HP:0006965)1.96030104
69Abnormality of DNA repair (HP:0003254)1.95953549
70Abnormality of the preputium (HP:0100587)1.94612734
71Increased serum lactate (HP:0002151)1.94487416
72Abnormal number of erythroid precursors (HP:0012131)1.93092769
73Cystic liver disease (HP:0006706)1.92687882
74Neoplasm of the adrenal cortex (HP:0100641)1.88079851
75Protruding tongue (HP:0010808)1.88036837
76IgG deficiency (HP:0004315)1.86833778
77Genetic anticipation (HP:0003743)1.86722108
78Abnormality of male internal genitalia (HP:0000022)1.86542788
79Ketoacidosis (HP:0001993)1.86405162
80Severe visual impairment (HP:0001141)1.85879242
81Clumsiness (HP:0002312)1.85473795
82Congenital hepatic fibrosis (HP:0002612)1.84914870
83Increased IgM level (HP:0003496)1.84620917
84Abnormality of the ileum (HP:0001549)1.84487892
85Decreased central vision (HP:0007663)1.84231298
86Meckel diverticulum (HP:0002245)1.83966749
87Duplicated collecting system (HP:0000081)1.83896695
88Leukocytosis (HP:0001974)1.83796891
89Sloping forehead (HP:0000340)1.83681709
90Hyperventilation (HP:0002883)1.81247942
91Acute encephalopathy (HP:0006846)1.79860638
92Lissencephaly (HP:0001339)1.79298826
93Lactic acidosis (HP:0003128)1.79022790
94Abnormality of the renal collecting system (HP:0004742)1.78862052
95Inability to walk (HP:0002540)1.76690736
96Methylmalonic aciduria (HP:0012120)1.76529403
97Hypoplasia of the pons (HP:0012110)1.75325146
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.72909170
99Decreased activity of mitochondrial respiratory chain (HP:0008972)1.72909170
100Colon cancer (HP:0003003)1.72024007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.94306592
2NUAK13.44381613
3FRK3.44075303
4CCNB13.32147396
5TAOK33.28696647
6MAP4K23.11074751
7KIT2.92791409
8BCKDK2.77287651
9TLK12.62965394
10NEK22.46075387
11FLT32.13175430
12MAP4K12.06166991
13INSRR2.01834119
14BMPR1B1.97460867
15TNK21.95879528
16CAMKK21.87199270
17TAF11.67786207
18ERN11.67304060
19TESK21.57868266
20TXK1.54946822
21MAPK131.52666878
22KDR1.51299050
23MAPKAPK31.50326892
24PIK3CA1.46008205
25TEC1.43188534
26ZAK1.42043009
27VRK11.40536533
28CAMK1D1.35301298
29WNK41.32552524
30SYK1.20438204
31MAPKAPK51.16852580
32MAP2K61.13267557
33IKBKB1.12754231
34BTK1.09846336
35ADRBK21.08192510
36WNK31.07390147
37FES1.03550669
38ATR1.02324275
39GRK11.02211601
40MAP3K70.98777189
41PIM20.96218693
42OXSR10.91622341
43CSF1R0.85864132
44GRK60.85034392
45RPS6KB20.84925876
46PLK40.83313211
47CAMK1G0.80454011
48ITK0.72169898
49LCK0.69838699
50MAP2K30.69490619
51IKBKE0.68426429
52TBK10.67158890
53MAPK110.66907515
54PRKCQ0.66422851
55CAMK10.65610759
56JAK30.63367714
57ADRBK10.61839460
58CHUK0.60876783
59PIK3CG0.60784311
60MARK30.59596955
61SIK20.59199592
62DAPK10.57185411
63CSNK1A1L0.57059591
64CAMKK10.52738483
65ACVR1B0.51732505
66CSNK1G30.50462608
67LYN0.49584364
68SRPK10.49138254
69MAP3K40.46553713
70CHEK20.46550745
71MAP3K110.46420599
72ATM0.45518257
73ZAP700.44949222
74PRKAA20.44168833
75MAPK120.43869011
76BRSK20.43540372
77PDK20.43334566
78RPS6KA50.43190827
79EIF2AK20.43019128
80NME10.39139143
81DYRK20.38988119
82HCK0.36991140
83PIM10.36918307
84PBK0.35814563
85PKN10.34293728
86PINK10.33814335
87GRK50.33693980
88TRPM70.32917317
89STK390.32767071
90PRKAA10.31821923
91CDK80.29865342
92PTK2B0.28756995
93CSNK1G10.28513796
94MAP2K20.28346845
95MKNK10.27786884
96IGF1R0.27575963
97MAPK30.27267869
98HIPK20.26885066
99MUSK0.26877723
100MAP2K70.26398286

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.49596072
2Base excision repair_Homo sapiens_hsa034103.06782320
3Fanconi anemia pathway_Homo sapiens_hsa034602.98814571
4Primary immunodeficiency_Homo sapiens_hsa053402.93684894
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.87313148
6RNA polymerase_Homo sapiens_hsa030202.57037112
7DNA replication_Homo sapiens_hsa030302.17668588
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.03764687
9Non-homologous end-joining_Homo sapiens_hsa034501.98488104
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97586089
11Asthma_Homo sapiens_hsa053101.96841760
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81538563
13Allograft rejection_Homo sapiens_hsa053301.76055640
14Caffeine metabolism_Homo sapiens_hsa002321.73519303
15Phototransduction_Homo sapiens_hsa047441.69681416
16Graft-versus-host disease_Homo sapiens_hsa053321.66091224
17Linoleic acid metabolism_Homo sapiens_hsa005911.64299511
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62765338
19Butanoate metabolism_Homo sapiens_hsa006501.62647358
20Autoimmune thyroid disease_Homo sapiens_hsa053201.61889643
21Pyrimidine metabolism_Homo sapiens_hsa002401.61567932
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59857086
23Peroxisome_Homo sapiens_hsa041461.57335222
24One carbon pool by folate_Homo sapiens_hsa006701.53079279
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.50806116
26Basal transcription factors_Homo sapiens_hsa030221.47089596
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44911122
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.42471870
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42122292
30Tryptophan metabolism_Homo sapiens_hsa003801.38969770
31Type I diabetes mellitus_Homo sapiens_hsa049401.37940585
32Mismatch repair_Homo sapiens_hsa034301.37386109
33Oxidative phosphorylation_Homo sapiens_hsa001901.34360189
34Nucleotide excision repair_Homo sapiens_hsa034201.33449223
35RNA degradation_Homo sapiens_hsa030181.27627147
36Nitrogen metabolism_Homo sapiens_hsa009101.27080796
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.19828123
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18063832
39Purine metabolism_Homo sapiens_hsa002301.16325908
40Parkinsons disease_Homo sapiens_hsa050121.15627792
41Lysine degradation_Homo sapiens_hsa003101.15091608
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12647695
43Propanoate metabolism_Homo sapiens_hsa006401.06356032
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05187611
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04040907
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03904454
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02255510
48Proteasome_Homo sapiens_hsa030501.01644097
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01286470
50Selenocompound metabolism_Homo sapiens_hsa004500.96847542
51ABC transporters_Homo sapiens_hsa020100.96064510
52Ether lipid metabolism_Homo sapiens_hsa005650.93604269
53Spliceosome_Homo sapiens_hsa030400.91301237
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90612017
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89276873
56RNA transport_Homo sapiens_hsa030130.87727533
57Ribosome_Homo sapiens_hsa030100.87081480
58Arachidonic acid metabolism_Homo sapiens_hsa005900.86894573
59Regulation of autophagy_Homo sapiens_hsa041400.84600252
60Olfactory transduction_Homo sapiens_hsa047400.83340561
61Hematopoietic cell lineage_Homo sapiens_hsa046400.80629461
62Taste transduction_Homo sapiens_hsa047420.79826999
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.73715420
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.72705481
65Chemical carcinogenesis_Homo sapiens_hsa052040.72298139
66Herpes simplex infection_Homo sapiens_hsa051680.71367879
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71334551
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70867399
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68622228
70Huntingtons disease_Homo sapiens_hsa050160.68526904
71Metabolic pathways_Homo sapiens_hsa011000.64248704
72Glycerolipid metabolism_Homo sapiens_hsa005610.62004793
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56688664
74Antigen processing and presentation_Homo sapiens_hsa046120.56312748
75Fatty acid elongation_Homo sapiens_hsa000620.56029432
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55064696
77Fatty acid degradation_Homo sapiens_hsa000710.53311904
78Retinol metabolism_Homo sapiens_hsa008300.50254278
79Calcium signaling pathway_Homo sapiens_hsa040200.50234076
80Fatty acid metabolism_Homo sapiens_hsa012120.49983138
81Platelet activation_Homo sapiens_hsa046110.49132867
82Systemic lupus erythematosus_Homo sapiens_hsa053220.46043634
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.45572859
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.44176277
85Epstein-Barr virus infection_Homo sapiens_hsa051690.42906005
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.42426479
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41876365
88Sulfur relay system_Homo sapiens_hsa041220.41334771
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39903870
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38073990
91Rheumatoid arthritis_Homo sapiens_hsa053230.36522913
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35815009
93African trypanosomiasis_Homo sapiens_hsa051430.35733519
94Acute myeloid leukemia_Homo sapiens_hsa052210.32203925
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.32143682
96Nicotine addiction_Homo sapiens_hsa050330.31283282
97Alzheimers disease_Homo sapiens_hsa050100.31109626
98Ovarian steroidogenesis_Homo sapiens_hsa049130.30212625
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29253494
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28241171

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