STAG3L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-histidine modification (GO:0018202)4.82441826
2proteasome assembly (GO:0043248)4.28317608
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22841642
4DNA double-strand break processing (GO:0000729)4.05802810
5kinetochore organization (GO:0051383)4.04843472
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.99072849
7positive regulation of mitochondrial fission (GO:0090141)3.79229079
8cullin deneddylation (GO:0010388)3.75833798
9protein complex biogenesis (GO:0070271)3.75015996
10kinetochore assembly (GO:0051382)3.72514820
11chromatin remodeling at centromere (GO:0031055)3.69569023
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68384248
13ATP synthesis coupled proton transport (GO:0015986)3.61413459
14energy coupled proton transport, down electrochemical gradient (GO:0015985)3.61413459
15protein deneddylation (GO:0000338)3.55938374
16mitochondrial respiratory chain complex assembly (GO:0033108)3.53923094
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.53687145
18NADH dehydrogenase complex assembly (GO:0010257)3.53687145
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.53687145
20L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.51155335
21CENP-A containing nucleosome assembly (GO:0034080)3.48338549
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.46603660
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46404274
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46404274
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.46017489
26replication fork processing (GO:0031297)3.43880098
27respiratory electron transport chain (GO:0022904)3.41588430
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37183963
29electron transport chain (GO:0022900)3.36522049
30respiratory chain complex IV assembly (GO:0008535)3.32426951
31protein K6-linked ubiquitination (GO:0085020)3.25207706
32resolution of meiotic recombination intermediates (GO:0000712)3.19544094
33epithelial cilium movement (GO:0003351)3.15888909
34protein neddylation (GO:0045116)3.15868933
35transcription from mitochondrial promoter (GO:0006390)3.15362529
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14783043
37meiotic chromosome segregation (GO:0045132)3.14606690
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13155330
39protein-cofactor linkage (GO:0018065)3.10657898
40cytochrome complex assembly (GO:0017004)3.10538522
41histone exchange (GO:0043486)3.10285099
42positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10048870
43chaperone-mediated protein transport (GO:0072321)3.08794202
44intraciliary transport (GO:0042073)3.08390721
45response to pheromone (GO:0019236)3.03951026
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02286513
47tRNA processing (GO:0008033)2.98345824
48somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95881224
49somatic hypermutation of immunoglobulin genes (GO:0016446)2.95881224
50amino acid salvage (GO:0043102)2.95746775
51L-methionine salvage (GO:0071267)2.95746775
52L-methionine biosynthetic process (GO:0071265)2.95746775
53recombinational repair (GO:0000725)2.91228313
54regulation of glucokinase activity (GO:0033131)2.90781843
55regulation of hexokinase activity (GO:1903299)2.90781843
56double-strand break repair via homologous recombination (GO:0000724)2.90199873
57mannosylation (GO:0097502)2.89909285
58DNA ligation (GO:0006266)2.89202796
59transcription elongation from RNA polymerase III promoter (GO:0006385)2.87440046
60termination of RNA polymerase III transcription (GO:0006386)2.87440046
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87402312
62DNA damage response, detection of DNA damage (GO:0042769)2.86509993
63platelet dense granule organization (GO:0060155)2.86304612
64regulation of DNA endoreduplication (GO:0032875)2.84726219
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83351274
66signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83351274
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83351274
68DNA catabolic process, exonucleolytic (GO:0000738)2.81383824
69organelle disassembly (GO:1903008)2.81005912
70regulation of cellular amino acid metabolic process (GO:0006521)2.80798483
71pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.80703674
72preassembly of GPI anchor in ER membrane (GO:0016254)2.80583275
73rRNA modification (GO:0000154)2.80578045
74intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79290702
75signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79290702
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76866399
77mitochondrial RNA metabolic process (GO:0000959)2.76535588
78maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74846538
79negative regulation of ligase activity (GO:0051352)2.73782008
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73782008
81base-excision repair, AP site formation (GO:0006285)2.72757363
82histone H2A acetylation (GO:0043968)2.72381911
83tRNA metabolic process (GO:0006399)2.71799897
84histone mRNA metabolic process (GO:0008334)2.71495874
85regulation of cilium movement (GO:0003352)2.71473412
86signal transduction involved in cell cycle checkpoint (GO:0072395)2.71270712
87non-recombinational repair (GO:0000726)2.68878093
88double-strand break repair via nonhomologous end joining (GO:0006303)2.68878093
89protein K11-linked ubiquitination (GO:0070979)2.68098422
90signal transduction involved in DNA damage checkpoint (GO:0072422)2.67863037
91signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67863037
92centriole replication (GO:0007099)2.67661017
93pseudouridine synthesis (GO:0001522)2.62454998
94metallo-sulfur cluster assembly (GO:0031163)2.62437586
95iron-sulfur cluster assembly (GO:0016226)2.62437586
96regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.62329837
97regulation of mitotic spindle checkpoint (GO:1903504)2.62329837
98positive regulation of ligase activity (GO:0051351)2.62324025
99protein targeting to mitochondrion (GO:0006626)2.62071985
100establishment of integrated proviral latency (GO:0075713)2.61817758

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.80616783
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.18446697
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.13749975
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.77889994
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.30036714
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85073506
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84638740
8ELK1_19687146_ChIP-ChIP_HELA_Human2.83332488
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.70399196
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.68334950
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59969829
12VDR_23849224_ChIP-Seq_CD4+_Human2.56427686
13ZNF274_21170338_ChIP-Seq_K562_Hela2.55384121
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48509768
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44518552
16FOXP3_21729870_ChIP-Seq_TREG_Human2.44300141
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37677417
18IGF1R_20145208_ChIP-Seq_DFB_Human2.27358944
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.20572704
20MYC_18940864_ChIP-ChIP_HL60_Human2.08691134
21FUS_26573619_Chip-Seq_HEK293_Human2.08133997
22VDR_22108803_ChIP-Seq_LS180_Human2.02882099
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.01234695
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97147129
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.97016935
26* EWS_26573619_Chip-Seq_HEK293_Human1.96703971
27PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90961666
28E2F7_22180533_ChIP-Seq_HELA_Human1.89706240
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88479416
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88180998
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81637976
32IRF1_19129219_ChIP-ChIP_H3396_Human1.74411229
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73681874
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72847955
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71490165
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.69784812
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.68418902
38DCP1A_22483619_ChIP-Seq_HELA_Human1.67129443
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59326415
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59190129
41GABP_19822575_ChIP-Seq_HepG2_Human1.58726987
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57382511
43TAF15_26573619_Chip-Seq_HEK293_Human1.56868861
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47270173
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46565109
46TTF2_22483619_ChIP-Seq_HELA_Human1.46177073
47P300_19829295_ChIP-Seq_ESCs_Human1.45422669
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45329542
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43336499
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40638088
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.40018530
52GBX2_23144817_ChIP-Seq_PC3_Human1.38331446
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32207733
54CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30589378
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28141202
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25626936
57* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25097928
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23943894
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23939397
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21692721
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17099098
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.14801613
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.12792929
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10609413
65* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10384072
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10185765
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10052242
68ER_23166858_ChIP-Seq_MCF-7_Human1.09745986
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07052247
70XRN2_22483619_ChIP-Seq_HELA_Human1.05271764
71SOX2_16153702_ChIP-ChIP_HESCs_Human1.04670837
72KDM5A_27292631_Chip-Seq_BREAST_Human1.04547813
73* TP53_22573176_ChIP-Seq_HFKS_Human1.04290431
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02666195
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00485502
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00391169
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99223905
78BCAT_22108803_ChIP-Seq_LS180_Human0.99152424
79CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98814889
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95368317
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95146371
82EZH2_27294783_Chip-Seq_NPCs_Mouse0.94695133
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92960598
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91996333
85MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90467041
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89050801
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87638960
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87409288
89CBP_20019798_ChIP-Seq_JUKART_Human0.87409288
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87191564
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86980152
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85070319
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84842022
94RNF2_27304074_Chip-Seq_NSC_Mouse0.83495478
95NANOG_19829295_ChIP-Seq_ESCs_Human0.83238401
96SOX2_19829295_ChIP-Seq_ESCs_Human0.83238401
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.82207615
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81989815
99AR_21909140_ChIP-Seq_LNCAP_Human0.79541951
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.78880515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.34101594
2MP0008058_abnormal_DNA_repair3.26498785
3MP0006292_abnormal_olfactory_placode3.16485167
4MP0002102_abnormal_ear_morphology3.06458885
5MP0010094_abnormal_chromosome_stability2.71110666
6MP0002938_white_spotting2.57377896
7MP0000372_irregular_coat_pigmentation2.56755441
8MP0003787_abnormal_imprinting2.52209330
9MP0002234_abnormal_pharynx_morphology2.48421640
10MP0003880_abnormal_central_pattern2.27686686
11MP0003136_yellow_coat_color2.18459535
12MP0002736_abnormal_nociception_after2.13980267
13MP0006072_abnormal_retinal_apoptosis2.11579028
14MP0008789_abnormal_olfactory_epithelium2.10958281
15MP0003718_maternal_effect1.96317610
16MP0006036_abnormal_mitochondrial_physio1.89932942
17MP0003786_premature_aging1.89494299
18MP0004043_abnormal_pH_regulation1.84625097
19MP0005075_abnormal_melanosome_morpholog1.83014659
20MP0005253_abnormal_eye_physiology1.75910242
21MP0005499_abnormal_olfactory_system1.74483205
22MP0005394_taste/olfaction_phenotype1.74483205
23MP0003186_abnormal_redox_activity1.74339291
24MP0005551_abnormal_eye_electrophysiolog1.73493508
25MP0003121_genomic_imprinting1.69621920
26MP0001529_abnormal_vocalization1.65079028
27MP0008932_abnormal_embryonic_tissue1.64732405
28MP0003077_abnormal_cell_cycle1.64311903
29MP0004145_abnormal_muscle_electrophysio1.63664400
30MP0008995_early_reproductive_senescence1.62896218
31MP0003693_abnormal_embryo_hatching1.59420111
32MP0006035_abnormal_mitochondrial_morpho1.57277592
33MP0002638_abnormal_pupillary_reflex1.51165935
34MP0001293_anophthalmia1.50765889
35MP0009697_abnormal_copulation1.47211812
36MP0004957_abnormal_blastocyst_morpholog1.46631682
37MP0002837_dystrophic_cardiac_calcinosis1.45099447
38MP0001984_abnormal_olfaction1.43418340
39MP0008057_abnormal_DNA_replication1.42533255
40MP0001764_abnormal_homeostasis1.41854736
41MP0003806_abnormal_nucleotide_metabolis1.40368299
42MP0001968_abnormal_touch/_nociception1.32918809
43MP0003122_maternal_imprinting1.32271662
44MP0000569_abnormal_digit_pigmentation1.32116602
45MP0006276_abnormal_autonomic_nervous1.30091353
46MP0005171_absent_coat_pigmentation1.23961694
47MP0002095_abnormal_skin_pigmentation1.21489971
48MP0003111_abnormal_nucleus_morphology1.20313839
49MP0001986_abnormal_taste_sensitivity1.18301940
50MP0004147_increased_porphyrin_level1.18200543
51MP0004133_heterotaxia1.17718742
52MP0002210_abnormal_sex_determination1.17109882
53MP0004142_abnormal_muscle_tone1.16496922
54MP0001929_abnormal_gametogenesis1.16351535
55MP0005174_abnormal_tail_pigmentation1.15957385
56MP0002090_abnormal_vision1.15748173
57MP0008007_abnormal_cellular_replicative1.14966506
58MP0005408_hypopigmentation1.11371996
59MP0002233_abnormal_nose_morphology1.11361724
60MP0009046_muscle_twitch1.07017722
61MP0000647_abnormal_sebaceous_gland1.05858659
62MP0005248_abnormal_Harderian_gland1.02516046
63MP0002160_abnormal_reproductive_system1.02330343
64MP0003890_abnormal_embryonic-extraembry1.01584033
65MP0000653_abnormal_sex_gland1.01565891
66MP0002653_abnormal_ependyma_morphology1.01403384
67MP0001485_abnormal_pinna_reflex0.99856282
68MP0003937_abnormal_limbs/digits/tail_de0.99777839
69MP0000358_abnormal_cell_content/0.99396894
70MP0005391_vision/eye_phenotype0.98936374
71MP0005084_abnormal_gallbladder_morpholo0.94316295
72MP0001145_abnormal_male_reproductive0.92636959
73MP0002751_abnormal_autonomic_nervous0.91309789
74MP0003567_abnormal_fetal_cardiomyocyte0.91156335
75MP0003646_muscle_fatigue0.90886472
76MP0002272_abnormal_nervous_system0.89949434
77MP0002928_abnormal_bile_duct0.89831486
78MP0001286_abnormal_eye_development0.89135172
79MP0001324_abnormal_eye_pigmentation0.88288613
80MP0001486_abnormal_startle_reflex0.87746783
81MP0003698_abnormal_male_reproductive0.86580693
82MP0000631_abnormal_neuroendocrine_gland0.85960776
83MP0000427_abnormal_hair_cycle0.84950513
84MP0000516_abnormal_urinary_system0.84704044
85MP0005367_renal/urinary_system_phenotyp0.84704044
86MP0005389_reproductive_system_phenotype0.84387546
87MP0003137_abnormal_impulse_conducting0.84281714
88MP0001119_abnormal_female_reproductive0.84112653
89MP0002752_abnormal_somatic_nervous0.83887344
90MP0005195_abnormal_posterior_eye0.83566423
91MP0000015_abnormal_ear_pigmentation0.82746303
92MP0004215_abnormal_myocardial_fiber0.82467595
93MP0001905_abnormal_dopamine_level0.81815037
94MP0008872_abnormal_physiological_respon0.80204759
95MP0010030_abnormal_orbit_morphology0.78957456
96MP0005423_abnormal_somatic_nervous0.77248782
97MP0000049_abnormal_middle_ear0.77040118
98MP0003938_abnormal_ear_development0.76915742
99MP0000778_abnormal_nervous_system0.76561733
100MP0005410_abnormal_fertilization0.76164983

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.50137130
2Abnormal mitochondria in muscle tissue (HP:0008316)4.99109735
3Hepatocellular necrosis (HP:0001404)4.97977616
4Acute encephalopathy (HP:0006846)4.81496522
5Progressive macrocephaly (HP:0004481)4.66673856
6Hepatic necrosis (HP:0002605)4.46461520
7Mitochondrial inheritance (HP:0001427)4.35890586
8Increased CSF lactate (HP:0002490)4.05687231
9Cerebral edema (HP:0002181)3.71941335
10Molar tooth sign on MRI (HP:0002419)3.23904101
11Abnormality of midbrain morphology (HP:0002418)3.23904101
12Medial flaring of the eyebrow (HP:0010747)3.16115087
13Pancreatic cysts (HP:0001737)3.01672844
14True hermaphroditism (HP:0010459)2.95188395
15Pancreatic fibrosis (HP:0100732)2.93629667
16Nephronophthisis (HP:0000090)2.91166455
17Colon cancer (HP:0003003)2.89300303
183-Methylglutaconic aciduria (HP:0003535)2.87459705
19Increased serum lactate (HP:0002151)2.84648190
20Increased hepatocellular lipid droplets (HP:0006565)2.69091965
21Abnormality of the labia minora (HP:0012880)2.67718714
22Respiratory failure (HP:0002878)2.58686812
23Optic disc pallor (HP:0000543)2.57954785
24CNS demyelination (HP:0007305)2.57950342
25Lactic acidosis (HP:0003128)2.55916182
26Congenital primary aphakia (HP:0007707)2.52527644
27Abnormality of the renal medulla (HP:0100957)2.50559162
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.49579392
29Lipid accumulation in hepatocytes (HP:0006561)2.48394702
30Gait imbalance (HP:0002141)2.45210514
31Exercise intolerance (HP:0003546)2.44480093
32Abnormality of the ileum (HP:0001549)2.40298692
33Meckel diverticulum (HP:0002245)2.39242464
34Abnormality of the anterior horn cell (HP:0006802)2.32205037
35Degeneration of anterior horn cells (HP:0002398)2.32205037
36Leukodystrophy (HP:0002415)2.29386261
37Nephrogenic diabetes insipidus (HP:0009806)2.27934098
38Bile duct proliferation (HP:0001408)2.25326808
39Abnormal biliary tract physiology (HP:0012439)2.25326808
40Abnormality of the renal cortex (HP:0011035)2.21252059
41Abnormality of chromosome stability (HP:0003220)2.21150705
42Intestinal atresia (HP:0011100)2.19848206
43Renal Fanconi syndrome (HP:0001994)2.12995325
44Tubulointerstitial nephritis (HP:0001970)2.12040181
45Abnormality of alanine metabolism (HP:0010916)2.10993206
46Hyperalaninemia (HP:0003348)2.10993206
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10993206
48Hyperglycinemia (HP:0002154)2.09206206
49Asplenia (HP:0001746)2.08740542
50Emotional lability (HP:0000712)2.08132460
51Lethargy (HP:0001254)2.07774000
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.07113101
53Abnormal lung lobation (HP:0002101)2.05319382
54Atrophy/Degeneration involving motor neurons (HP:0007373)2.04518929
55Vaginal atresia (HP:0000148)2.01228672
56Genital tract atresia (HP:0001827)2.00001535
57Supernumerary spleens (HP:0009799)1.99866374
58Abnormal rod and cone electroretinograms (HP:0008323)1.98343839
59Sloping forehead (HP:0000340)1.98322590
60Chromsome breakage (HP:0040012)1.94861810
61Tubular atrophy (HP:0000092)1.94343942
62Methylmalonic acidemia (HP:0002912)1.90716407
63Volvulus (HP:0002580)1.89561403
64Small intestinal stenosis (HP:0012848)1.89553242
65Duodenal stenosis (HP:0100867)1.89553242
66Aplasia/Hypoplasia of the fovea (HP:0008060)1.88455853
67Hypoplasia of the fovea (HP:0007750)1.88455853
68Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88060972
69Abnormal protein glycosylation (HP:0012346)1.86765580
70Abnormal glycosylation (HP:0012345)1.86765580
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.86765580
72Abnormal protein N-linked glycosylation (HP:0012347)1.86765580
73Congenital stationary night blindness (HP:0007642)1.86503072
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.86273013
75Decreased activity of mitochondrial respiratory chain (HP:0008972)1.86273013
76Abnormality of the preputium (HP:0100587)1.85707355
77Abolished electroretinogram (ERG) (HP:0000550)1.85061229
78Abnormality of the fovea (HP:0000493)1.84436820
79Sclerocornea (HP:0000647)1.83958466
80Hypoplastic pelvis (HP:0008839)1.83747969
81Abnormality of the duodenum (HP:0002246)1.83678598
82Aganglionic megacolon (HP:0002251)1.82850570
83Renal cortical cysts (HP:0000803)1.81209709
84Abnormality of serum amino acid levels (HP:0003112)1.80907759
85Type I transferrin isoform profile (HP:0003642)1.80660815
86Absent thumb (HP:0009777)1.80313540
87Increased intramyocellular lipid droplets (HP:0012240)1.79863739
88Methylmalonic aciduria (HP:0012120)1.78466820
89X-linked dominant inheritance (HP:0001423)1.78067885
90Male pseudohermaphroditism (HP:0000037)1.77205368
91Poor coordination (HP:0002370)1.76948468
92Triphalangeal thumb (HP:0001199)1.75719819
93Increased serum pyruvate (HP:0003542)1.74068775
94Postaxial foot polydactyly (HP:0001830)1.73517729
95Ependymoma (HP:0002888)1.72525660
96Cerebral hypomyelination (HP:0006808)1.71342228
97Astigmatism (HP:0000483)1.68127552
98Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66807278
99Amyotrophic lateral sclerosis (HP:0007354)1.66679749
100Oculomotor apraxia (HP:0000657)1.66196060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB12.99508359
2TRIM282.89698375
3NUAK12.87524800
4EIF2AK12.74195945
5MAP4K22.68497721
6WNK32.44177061
7BMPR1B2.35510934
8VRK22.33017571
9CCNB12.17498600
10STK162.15363319
11ZAK2.09227010
12NEK12.07733907
13PDK22.03940675
14WEE12.02128660
15MAP3K41.99564871
16MKNK21.92461800
17CDK191.86967298
18PLK41.83445082
19CDC71.79595943
20FRK1.75538603
21EIF2AK31.73476412
22ERBB31.68143730
23PLK31.64510288
24PLK21.61393565
25SRPK11.54496807
26MAP3K121.54352058
27MKNK11.54220409
28MAP2K71.53641750
29VRK11.53446182
30TNIK1.53127484
31ACVR1B1.49759845
32GRK11.46248207
33BCKDK1.41878286
34BRSK21.41666502
35MST41.39359325
36MAPK131.35568200
37PBK1.34528134
38EPHA41.27500765
39PLK11.18339920
40ADRBK21.17284820
41BCR1.11238582
42CSNK1G21.10301156
43PINK11.06011482
44CSNK1G11.05731169
45TAOK30.99075958
46CSNK1G30.97079142
47DYRK20.94842026
48FLT30.89212686
49CASK0.88118434
50NME10.87873353
51TLK10.85162708
52ATR0.83966222
53TAF10.81578110
54PAK30.80425939
55DYRK30.78892922
56TTK0.78810818
57TSSK60.78612946
58AKT30.78012758
59AURKB0.73075207
60STK390.72796092
61OBSCN0.70724724
62BRSK10.69973309
63PRKCG0.69809675
64CSNK1A1L0.64860824
65NEK20.62252362
66TIE10.61597647
67MINK10.60070292
68STK30.58515901
69MARK30.56063606
70ATM0.54659733
71RPS6KA40.54116542
72CHEK20.53175065
73PRKCI0.53051716
74PRKCE0.51530071
75WNK40.50370105
76EIF2AK20.50269992
77CSNK2A10.49477236
78TGFBR10.49038563
79CSNK1A10.47496671
80CDK80.46183007
81STK38L0.43599782
82PNCK0.43420382
83CSNK2A20.43302843
84OXSR10.41665082
85RPS6KA50.40447225
86INSRR0.40031026
87TEC0.37269810
88MUSK0.36372612
89CHEK10.33754743
90PIM20.33519599
91PKN10.32881230
92MAP2K40.29927671
93TXK0.29751192
94CAMK2A0.28534607
95PRKACA0.27246220
96PRKACB0.25581497
97GRK70.25472452
98LIMK10.24999736
99CAMK2D0.24714001
100MYLK0.24300571

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.59226001
2Oxidative phosphorylation_Homo sapiens_hsa001903.54339122
3Parkinsons disease_Homo sapiens_hsa050123.11263512
4Protein export_Homo sapiens_hsa030603.00766429
5Mismatch repair_Homo sapiens_hsa034302.84516340
6Homologous recombination_Homo sapiens_hsa034402.84263015
7Non-homologous end-joining_Homo sapiens_hsa034502.65708419
8Fanconi anemia pathway_Homo sapiens_hsa034602.62439847
9RNA polymerase_Homo sapiens_hsa030202.45758388
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.26883869
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18361569
12Huntingtons disease_Homo sapiens_hsa050162.14617401
13DNA replication_Homo sapiens_hsa030302.09620762
14Ribosome_Homo sapiens_hsa030102.08886040
15Nucleotide excision repair_Homo sapiens_hsa034202.07793249
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05696444
17Base excision repair_Homo sapiens_hsa034102.02489987
18Basal transcription factors_Homo sapiens_hsa030221.97716521
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97413728
20Propanoate metabolism_Homo sapiens_hsa006401.91709702
21Alzheimers disease_Homo sapiens_hsa050101.86164908
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83130950
23RNA degradation_Homo sapiens_hsa030181.68092287
24RNA transport_Homo sapiens_hsa030131.61950803
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59455742
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.59217395
27Pyrimidine metabolism_Homo sapiens_hsa002401.54224515
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53332998
29Phototransduction_Homo sapiens_hsa047441.49172836
30Fatty acid elongation_Homo sapiens_hsa000621.48043635
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46786852
32Spliceosome_Homo sapiens_hsa030401.42757790
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36989245
34Butanoate metabolism_Homo sapiens_hsa006501.30688411
35One carbon pool by folate_Homo sapiens_hsa006701.28456304
36Purine metabolism_Homo sapiens_hsa002301.18434299
37Cardiac muscle contraction_Homo sapiens_hsa042601.16449455
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13102820
39Collecting duct acid secretion_Homo sapiens_hsa049661.11277737
40Pyruvate metabolism_Homo sapiens_hsa006201.09821490
41Peroxisome_Homo sapiens_hsa041461.07889702
42Steroid biosynthesis_Homo sapiens_hsa001001.05456149
43Cell cycle_Homo sapiens_hsa041100.99622490
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.97880612
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89615857
46Metabolic pathways_Homo sapiens_hsa011000.88665747
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85368936
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81846265
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81824681
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79332629
51Tryptophan metabolism_Homo sapiens_hsa003800.75254578
52Selenocompound metabolism_Homo sapiens_hsa004500.75099713
53Glutathione metabolism_Homo sapiens_hsa004800.73933879
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73594037
55Folate biosynthesis_Homo sapiens_hsa007900.72901409
56Regulation of autophagy_Homo sapiens_hsa041400.72271897
57p53 signaling pathway_Homo sapiens_hsa041150.70383623
58Nitrogen metabolism_Homo sapiens_hsa009100.69102147
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.68842853
60Oocyte meiosis_Homo sapiens_hsa041140.67900886
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66843199
62Carbon metabolism_Homo sapiens_hsa012000.65055636
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63079523
64N-Glycan biosynthesis_Homo sapiens_hsa005100.62541367
65Olfactory transduction_Homo sapiens_hsa047400.59344350
66Vitamin B6 metabolism_Homo sapiens_hsa007500.54865699
67Biosynthesis of amino acids_Homo sapiens_hsa012300.53616132
68Linoleic acid metabolism_Homo sapiens_hsa005910.53464768
69Nicotine addiction_Homo sapiens_hsa050330.52455656
70Arginine and proline metabolism_Homo sapiens_hsa003300.51575395
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51484848
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49269926
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48099407
74Fatty acid metabolism_Homo sapiens_hsa012120.45781536
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45460774
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.45429013
77mRNA surveillance pathway_Homo sapiens_hsa030150.45211905
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44222099
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44129968
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43640582
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42339915
82Caffeine metabolism_Homo sapiens_hsa002320.41825334
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41453075
84Chemical carcinogenesis_Homo sapiens_hsa052040.40214777
85Tyrosine metabolism_Homo sapiens_hsa003500.39798213
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.39466203
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38048887
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37888421
89Fatty acid degradation_Homo sapiens_hsa000710.37682751
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36103553
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36052335
92Ether lipid metabolism_Homo sapiens_hsa005650.34060306
93beta-Alanine metabolism_Homo sapiens_hsa004100.33327609
94Sulfur metabolism_Homo sapiens_hsa009200.32787279
95Lysine degradation_Homo sapiens_hsa003100.29586021
96Hedgehog signaling pathway_Homo sapiens_hsa043400.27720236
97Sulfur relay system_Homo sapiens_hsa041220.26757000
98Circadian rhythm_Homo sapiens_hsa047100.24777719
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.24300322
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23563791

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