Rank | Gene Set | Z-score |
---|---|---|
1 | peptidyl-histidine modification (GO:0018202) | 4.82441826 |
2 | proteasome assembly (GO:0043248) | 4.28317608 |
3 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.22841642 |
4 | DNA double-strand break processing (GO:0000729) | 4.05802810 |
5 | kinetochore organization (GO:0051383) | 4.04843472 |
6 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.99072849 |
7 | positive regulation of mitochondrial fission (GO:0090141) | 3.79229079 |
8 | cullin deneddylation (GO:0010388) | 3.75833798 |
9 | protein complex biogenesis (GO:0070271) | 3.75015996 |
10 | kinetochore assembly (GO:0051382) | 3.72514820 |
11 | chromatin remodeling at centromere (GO:0031055) | 3.69569023 |
12 | epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287) | 3.68384248 |
13 | ATP synthesis coupled proton transport (GO:0015986) | 3.61413459 |
14 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.61413459 |
15 | protein deneddylation (GO:0000338) | 3.55938374 |
16 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.53923094 |
17 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.53687145 |
18 | NADH dehydrogenase complex assembly (GO:0010257) | 3.53687145 |
19 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.53687145 |
20 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.51155335 |
21 | CENP-A containing nucleosome assembly (GO:0034080) | 3.48338549 |
22 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.46603660 |
23 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.46404274 |
24 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.46404274 |
25 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.46017489 |
26 | replication fork processing (GO:0031297) | 3.43880098 |
27 | respiratory electron transport chain (GO:0022904) | 3.41588430 |
28 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.37183963 |
29 | electron transport chain (GO:0022900) | 3.36522049 |
30 | respiratory chain complex IV assembly (GO:0008535) | 3.32426951 |
31 | protein K6-linked ubiquitination (GO:0085020) | 3.25207706 |
32 | resolution of meiotic recombination intermediates (GO:0000712) | 3.19544094 |
33 | epithelial cilium movement (GO:0003351) | 3.15888909 |
34 | protein neddylation (GO:0045116) | 3.15868933 |
35 | transcription from mitochondrial promoter (GO:0006390) | 3.15362529 |
36 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.14783043 |
37 | meiotic chromosome segregation (GO:0045132) | 3.14606690 |
38 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.13155330 |
39 | protein-cofactor linkage (GO:0018065) | 3.10657898 |
40 | cytochrome complex assembly (GO:0017004) | 3.10538522 |
41 | histone exchange (GO:0043486) | 3.10285099 |
42 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.10048870 |
43 | chaperone-mediated protein transport (GO:0072321) | 3.08794202 |
44 | intraciliary transport (GO:0042073) | 3.08390721 |
45 | response to pheromone (GO:0019236) | 3.03951026 |
46 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.02286513 |
47 | tRNA processing (GO:0008033) | 2.98345824 |
48 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 2.95881224 |
49 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 2.95881224 |
50 | amino acid salvage (GO:0043102) | 2.95746775 |
51 | L-methionine salvage (GO:0071267) | 2.95746775 |
52 | L-methionine biosynthetic process (GO:0071265) | 2.95746775 |
53 | recombinational repair (GO:0000725) | 2.91228313 |
54 | regulation of glucokinase activity (GO:0033131) | 2.90781843 |
55 | regulation of hexokinase activity (GO:1903299) | 2.90781843 |
56 | double-strand break repair via homologous recombination (GO:0000724) | 2.90199873 |
57 | mannosylation (GO:0097502) | 2.89909285 |
58 | DNA ligation (GO:0006266) | 2.89202796 |
59 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.87440046 |
60 | termination of RNA polymerase III transcription (GO:0006386) | 2.87440046 |
61 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 2.87402312 |
62 | DNA damage response, detection of DNA damage (GO:0042769) | 2.86509993 |
63 | platelet dense granule organization (GO:0060155) | 2.86304612 |
64 | regulation of DNA endoreduplication (GO:0032875) | 2.84726219 |
65 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.83351274 |
66 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.83351274 |
67 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.83351274 |
68 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.81383824 |
69 | organelle disassembly (GO:1903008) | 2.81005912 |
70 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.80798483 |
71 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.80703674 |
72 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.80583275 |
73 | rRNA modification (GO:0000154) | 2.80578045 |
74 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.79290702 |
75 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.79290702 |
76 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.76866399 |
77 | mitochondrial RNA metabolic process (GO:0000959) | 2.76535588 |
78 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 2.74846538 |
79 | negative regulation of ligase activity (GO:0051352) | 2.73782008 |
80 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.73782008 |
81 | base-excision repair, AP site formation (GO:0006285) | 2.72757363 |
82 | histone H2A acetylation (GO:0043968) | 2.72381911 |
83 | tRNA metabolic process (GO:0006399) | 2.71799897 |
84 | histone mRNA metabolic process (GO:0008334) | 2.71495874 |
85 | regulation of cilium movement (GO:0003352) | 2.71473412 |
86 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.71270712 |
87 | non-recombinational repair (GO:0000726) | 2.68878093 |
88 | double-strand break repair via nonhomologous end joining (GO:0006303) | 2.68878093 |
89 | protein K11-linked ubiquitination (GO:0070979) | 2.68098422 |
90 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.67863037 |
91 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.67863037 |
92 | centriole replication (GO:0007099) | 2.67661017 |
93 | pseudouridine synthesis (GO:0001522) | 2.62454998 |
94 | metallo-sulfur cluster assembly (GO:0031163) | 2.62437586 |
95 | iron-sulfur cluster assembly (GO:0016226) | 2.62437586 |
96 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.62329837 |
97 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.62329837 |
98 | positive regulation of ligase activity (GO:0051351) | 2.62324025 |
99 | protein targeting to mitochondrion (GO:0006626) | 2.62071985 |
100 | establishment of integrated proviral latency (GO:0075713) | 2.61817758 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.80616783 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.18446697 |
3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.13749975 |
4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.77889994 |
5 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.30036714 |
6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.85073506 |
7 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.84638740 |
8 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.83332488 |
9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.70399196 |
10 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.68334950 |
11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.59969829 |
12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.56427686 |
13 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.55384121 |
14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.48509768 |
15 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.44518552 |
16 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.44300141 |
17 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.37677417 |
18 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.27358944 |
19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.20572704 |
20 | MYC_18940864_ChIP-ChIP_HL60_Human | 2.08691134 |
21 | FUS_26573619_Chip-Seq_HEK293_Human | 2.08133997 |
22 | VDR_22108803_ChIP-Seq_LS180_Human | 2.02882099 |
23 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.01234695 |
24 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.97147129 |
25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.97016935 |
26 | * EWS_26573619_Chip-Seq_HEK293_Human | 1.96703971 |
27 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.90961666 |
28 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.89706240 |
29 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.88479416 |
30 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.88180998 |
31 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.81637976 |
32 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.74411229 |
33 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.73681874 |
34 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.72847955 |
35 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.71490165 |
36 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.69784812 |
37 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.68418902 |
38 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.67129443 |
39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.59326415 |
40 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.59190129 |
41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.58726987 |
42 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.57382511 |
43 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.56868861 |
44 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.47270173 |
45 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.46565109 |
46 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.46177073 |
47 | P300_19829295_ChIP-Seq_ESCs_Human | 1.45422669 |
48 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.45329542 |
49 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.43336499 |
50 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.40638088 |
51 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.40018530 |
52 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.38331446 |
53 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.32207733 |
54 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.30589378 |
55 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.28141202 |
56 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.25626936 |
57 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.25097928 |
58 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.23943894 |
59 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.23939397 |
60 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.21692721 |
61 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.17099098 |
62 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.14801613 |
63 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.12792929 |
64 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.10609413 |
65 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.10384072 |
66 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.10185765 |
67 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.10052242 |
68 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.09745986 |
69 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.07052247 |
70 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.05271764 |
71 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.04670837 |
72 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.04547813 |
73 | * TP53_22573176_ChIP-Seq_HFKS_Human | 1.04290431 |
74 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.02666195 |
75 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.00485502 |
76 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.00391169 |
77 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.99223905 |
78 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.99152424 |
79 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.98814889 |
80 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 0.95368317 |
81 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 0.95146371 |
82 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.94695133 |
83 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 0.92960598 |
84 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.91996333 |
85 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.90467041 |
86 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.89050801 |
87 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.87638960 |
88 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.87409288 |
89 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.87409288 |
90 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.87191564 |
91 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.86980152 |
92 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.85070319 |
93 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.84842022 |
94 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.83495478 |
95 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.83238401 |
96 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.83238401 |
97 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.82207615 |
98 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.81989815 |
99 | AR_21909140_ChIP-Seq_LNCAP_Human | 0.79541951 |
100 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.78880515 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0008877_abnormal_DNA_methylation | 3.34101594 |
2 | MP0008058_abnormal_DNA_repair | 3.26498785 |
3 | MP0006292_abnormal_olfactory_placode | 3.16485167 |
4 | MP0002102_abnormal_ear_morphology | 3.06458885 |
5 | MP0010094_abnormal_chromosome_stability | 2.71110666 |
6 | MP0002938_white_spotting | 2.57377896 |
7 | MP0000372_irregular_coat_pigmentation | 2.56755441 |
8 | MP0003787_abnormal_imprinting | 2.52209330 |
9 | MP0002234_abnormal_pharynx_morphology | 2.48421640 |
10 | MP0003880_abnormal_central_pattern | 2.27686686 |
11 | MP0003136_yellow_coat_color | 2.18459535 |
12 | MP0002736_abnormal_nociception_after | 2.13980267 |
13 | MP0006072_abnormal_retinal_apoptosis | 2.11579028 |
14 | MP0008789_abnormal_olfactory_epithelium | 2.10958281 |
15 | MP0003718_maternal_effect | 1.96317610 |
16 | MP0006036_abnormal_mitochondrial_physio | 1.89932942 |
17 | MP0003786_premature_aging | 1.89494299 |
18 | MP0004043_abnormal_pH_regulation | 1.84625097 |
19 | MP0005075_abnormal_melanosome_morpholog | 1.83014659 |
20 | MP0005253_abnormal_eye_physiology | 1.75910242 |
21 | MP0005499_abnormal_olfactory_system | 1.74483205 |
22 | MP0005394_taste/olfaction_phenotype | 1.74483205 |
23 | MP0003186_abnormal_redox_activity | 1.74339291 |
24 | MP0005551_abnormal_eye_electrophysiolog | 1.73493508 |
25 | MP0003121_genomic_imprinting | 1.69621920 |
26 | MP0001529_abnormal_vocalization | 1.65079028 |
27 | MP0008932_abnormal_embryonic_tissue | 1.64732405 |
28 | MP0003077_abnormal_cell_cycle | 1.64311903 |
29 | MP0004145_abnormal_muscle_electrophysio | 1.63664400 |
30 | MP0008995_early_reproductive_senescence | 1.62896218 |
31 | MP0003693_abnormal_embryo_hatching | 1.59420111 |
32 | MP0006035_abnormal_mitochondrial_morpho | 1.57277592 |
33 | MP0002638_abnormal_pupillary_reflex | 1.51165935 |
34 | MP0001293_anophthalmia | 1.50765889 |
35 | MP0009697_abnormal_copulation | 1.47211812 |
36 | MP0004957_abnormal_blastocyst_morpholog | 1.46631682 |
37 | MP0002837_dystrophic_cardiac_calcinosis | 1.45099447 |
38 | MP0001984_abnormal_olfaction | 1.43418340 |
39 | MP0008057_abnormal_DNA_replication | 1.42533255 |
40 | MP0001764_abnormal_homeostasis | 1.41854736 |
41 | MP0003806_abnormal_nucleotide_metabolis | 1.40368299 |
42 | MP0001968_abnormal_touch/_nociception | 1.32918809 |
43 | MP0003122_maternal_imprinting | 1.32271662 |
44 | MP0000569_abnormal_digit_pigmentation | 1.32116602 |
45 | MP0006276_abnormal_autonomic_nervous | 1.30091353 |
46 | MP0005171_absent_coat_pigmentation | 1.23961694 |
47 | MP0002095_abnormal_skin_pigmentation | 1.21489971 |
48 | MP0003111_abnormal_nucleus_morphology | 1.20313839 |
49 | MP0001986_abnormal_taste_sensitivity | 1.18301940 |
50 | MP0004147_increased_porphyrin_level | 1.18200543 |
51 | MP0004133_heterotaxia | 1.17718742 |
52 | MP0002210_abnormal_sex_determination | 1.17109882 |
53 | MP0004142_abnormal_muscle_tone | 1.16496922 |
54 | MP0001929_abnormal_gametogenesis | 1.16351535 |
55 | MP0005174_abnormal_tail_pigmentation | 1.15957385 |
56 | MP0002090_abnormal_vision | 1.15748173 |
57 | MP0008007_abnormal_cellular_replicative | 1.14966506 |
58 | MP0005408_hypopigmentation | 1.11371996 |
59 | MP0002233_abnormal_nose_morphology | 1.11361724 |
60 | MP0009046_muscle_twitch | 1.07017722 |
61 | MP0000647_abnormal_sebaceous_gland | 1.05858659 |
62 | MP0005248_abnormal_Harderian_gland | 1.02516046 |
63 | MP0002160_abnormal_reproductive_system | 1.02330343 |
64 | MP0003890_abnormal_embryonic-extraembry | 1.01584033 |
65 | MP0000653_abnormal_sex_gland | 1.01565891 |
66 | MP0002653_abnormal_ependyma_morphology | 1.01403384 |
67 | MP0001485_abnormal_pinna_reflex | 0.99856282 |
68 | MP0003937_abnormal_limbs/digits/tail_de | 0.99777839 |
69 | MP0000358_abnormal_cell_content/ | 0.99396894 |
70 | MP0005391_vision/eye_phenotype | 0.98936374 |
71 | MP0005084_abnormal_gallbladder_morpholo | 0.94316295 |
72 | MP0001145_abnormal_male_reproductive | 0.92636959 |
73 | MP0002751_abnormal_autonomic_nervous | 0.91309789 |
74 | MP0003567_abnormal_fetal_cardiomyocyte | 0.91156335 |
75 | MP0003646_muscle_fatigue | 0.90886472 |
76 | MP0002272_abnormal_nervous_system | 0.89949434 |
77 | MP0002928_abnormal_bile_duct | 0.89831486 |
78 | MP0001286_abnormal_eye_development | 0.89135172 |
79 | MP0001324_abnormal_eye_pigmentation | 0.88288613 |
80 | MP0001486_abnormal_startle_reflex | 0.87746783 |
81 | MP0003698_abnormal_male_reproductive | 0.86580693 |
82 | MP0000631_abnormal_neuroendocrine_gland | 0.85960776 |
83 | MP0000427_abnormal_hair_cycle | 0.84950513 |
84 | MP0000516_abnormal_urinary_system | 0.84704044 |
85 | MP0005367_renal/urinary_system_phenotyp | 0.84704044 |
86 | MP0005389_reproductive_system_phenotype | 0.84387546 |
87 | MP0003137_abnormal_impulse_conducting | 0.84281714 |
88 | MP0001119_abnormal_female_reproductive | 0.84112653 |
89 | MP0002752_abnormal_somatic_nervous | 0.83887344 |
90 | MP0005195_abnormal_posterior_eye | 0.83566423 |
91 | MP0000015_abnormal_ear_pigmentation | 0.82746303 |
92 | MP0004215_abnormal_myocardial_fiber | 0.82467595 |
93 | MP0001905_abnormal_dopamine_level | 0.81815037 |
94 | MP0008872_abnormal_physiological_respon | 0.80204759 |
95 | MP0010030_abnormal_orbit_morphology | 0.78957456 |
96 | MP0005423_abnormal_somatic_nervous | 0.77248782 |
97 | MP0000049_abnormal_middle_ear | 0.77040118 |
98 | MP0003938_abnormal_ear_development | 0.76915742 |
99 | MP0000778_abnormal_nervous_system | 0.76561733 |
100 | MP0005410_abnormal_fertilization | 0.76164983 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 5.50137130 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.99109735 |
3 | Hepatocellular necrosis (HP:0001404) | 4.97977616 |
4 | Acute encephalopathy (HP:0006846) | 4.81496522 |
5 | Progressive macrocephaly (HP:0004481) | 4.66673856 |
6 | Hepatic necrosis (HP:0002605) | 4.46461520 |
7 | Mitochondrial inheritance (HP:0001427) | 4.35890586 |
8 | Increased CSF lactate (HP:0002490) | 4.05687231 |
9 | Cerebral edema (HP:0002181) | 3.71941335 |
10 | Molar tooth sign on MRI (HP:0002419) | 3.23904101 |
11 | Abnormality of midbrain morphology (HP:0002418) | 3.23904101 |
12 | Medial flaring of the eyebrow (HP:0010747) | 3.16115087 |
13 | Pancreatic cysts (HP:0001737) | 3.01672844 |
14 | True hermaphroditism (HP:0010459) | 2.95188395 |
15 | Pancreatic fibrosis (HP:0100732) | 2.93629667 |
16 | Nephronophthisis (HP:0000090) | 2.91166455 |
17 | Colon cancer (HP:0003003) | 2.89300303 |
18 | 3-Methylglutaconic aciduria (HP:0003535) | 2.87459705 |
19 | Increased serum lactate (HP:0002151) | 2.84648190 |
20 | Increased hepatocellular lipid droplets (HP:0006565) | 2.69091965 |
21 | Abnormality of the labia minora (HP:0012880) | 2.67718714 |
22 | Respiratory failure (HP:0002878) | 2.58686812 |
23 | Optic disc pallor (HP:0000543) | 2.57954785 |
24 | CNS demyelination (HP:0007305) | 2.57950342 |
25 | Lactic acidosis (HP:0003128) | 2.55916182 |
26 | Congenital primary aphakia (HP:0007707) | 2.52527644 |
27 | Abnormality of the renal medulla (HP:0100957) | 2.50559162 |
28 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.49579392 |
29 | Lipid accumulation in hepatocytes (HP:0006561) | 2.48394702 |
30 | Gait imbalance (HP:0002141) | 2.45210514 |
31 | Exercise intolerance (HP:0003546) | 2.44480093 |
32 | Abnormality of the ileum (HP:0001549) | 2.40298692 |
33 | Meckel diverticulum (HP:0002245) | 2.39242464 |
34 | Abnormality of the anterior horn cell (HP:0006802) | 2.32205037 |
35 | Degeneration of anterior horn cells (HP:0002398) | 2.32205037 |
36 | Leukodystrophy (HP:0002415) | 2.29386261 |
37 | Nephrogenic diabetes insipidus (HP:0009806) | 2.27934098 |
38 | Bile duct proliferation (HP:0001408) | 2.25326808 |
39 | Abnormal biliary tract physiology (HP:0012439) | 2.25326808 |
40 | Abnormality of the renal cortex (HP:0011035) | 2.21252059 |
41 | Abnormality of chromosome stability (HP:0003220) | 2.21150705 |
42 | Intestinal atresia (HP:0011100) | 2.19848206 |
43 | Renal Fanconi syndrome (HP:0001994) | 2.12995325 |
44 | Tubulointerstitial nephritis (HP:0001970) | 2.12040181 |
45 | Abnormality of alanine metabolism (HP:0010916) | 2.10993206 |
46 | Hyperalaninemia (HP:0003348) | 2.10993206 |
47 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.10993206 |
48 | Hyperglycinemia (HP:0002154) | 2.09206206 |
49 | Asplenia (HP:0001746) | 2.08740542 |
50 | Emotional lability (HP:0000712) | 2.08132460 |
51 | Lethargy (HP:0001254) | 2.07774000 |
52 | Aplasia/Hypoplasia of the spleen (HP:0010451) | 2.07113101 |
53 | Abnormal lung lobation (HP:0002101) | 2.05319382 |
54 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.04518929 |
55 | Vaginal atresia (HP:0000148) | 2.01228672 |
56 | Genital tract atresia (HP:0001827) | 2.00001535 |
57 | Supernumerary spleens (HP:0009799) | 1.99866374 |
58 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.98343839 |
59 | Sloping forehead (HP:0000340) | 1.98322590 |
60 | Chromsome breakage (HP:0040012) | 1.94861810 |
61 | Tubular atrophy (HP:0000092) | 1.94343942 |
62 | Methylmalonic acidemia (HP:0002912) | 1.90716407 |
63 | Volvulus (HP:0002580) | 1.89561403 |
64 | Small intestinal stenosis (HP:0012848) | 1.89553242 |
65 | Duodenal stenosis (HP:0100867) | 1.89553242 |
66 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.88455853 |
67 | Hypoplasia of the fovea (HP:0007750) | 1.88455853 |
68 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.88060972 |
69 | Abnormal protein glycosylation (HP:0012346) | 1.86765580 |
70 | Abnormal glycosylation (HP:0012345) | 1.86765580 |
71 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.86765580 |
72 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.86765580 |
73 | Congenital stationary night blindness (HP:0007642) | 1.86503072 |
74 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 1.86273013 |
75 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 1.86273013 |
76 | Abnormality of the preputium (HP:0100587) | 1.85707355 |
77 | Abolished electroretinogram (ERG) (HP:0000550) | 1.85061229 |
78 | Abnormality of the fovea (HP:0000493) | 1.84436820 |
79 | Sclerocornea (HP:0000647) | 1.83958466 |
80 | Hypoplastic pelvis (HP:0008839) | 1.83747969 |
81 | Abnormality of the duodenum (HP:0002246) | 1.83678598 |
82 | Aganglionic megacolon (HP:0002251) | 1.82850570 |
83 | Renal cortical cysts (HP:0000803) | 1.81209709 |
84 | Abnormality of serum amino acid levels (HP:0003112) | 1.80907759 |
85 | Type I transferrin isoform profile (HP:0003642) | 1.80660815 |
86 | Absent thumb (HP:0009777) | 1.80313540 |
87 | Increased intramyocellular lipid droplets (HP:0012240) | 1.79863739 |
88 | Methylmalonic aciduria (HP:0012120) | 1.78466820 |
89 | X-linked dominant inheritance (HP:0001423) | 1.78067885 |
90 | Male pseudohermaphroditism (HP:0000037) | 1.77205368 |
91 | Poor coordination (HP:0002370) | 1.76948468 |
92 | Triphalangeal thumb (HP:0001199) | 1.75719819 |
93 | Increased serum pyruvate (HP:0003542) | 1.74068775 |
94 | Postaxial foot polydactyly (HP:0001830) | 1.73517729 |
95 | Ependymoma (HP:0002888) | 1.72525660 |
96 | Cerebral hypomyelination (HP:0006808) | 1.71342228 |
97 | Astigmatism (HP:0000483) | 1.68127552 |
98 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.66807278 |
99 | Amyotrophic lateral sclerosis (HP:0007354) | 1.66679749 |
100 | Oculomotor apraxia (HP:0000657) | 1.66196060 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BUB1 | 2.99508359 |
2 | TRIM28 | 2.89698375 |
3 | NUAK1 | 2.87524800 |
4 | EIF2AK1 | 2.74195945 |
5 | MAP4K2 | 2.68497721 |
6 | WNK3 | 2.44177061 |
7 | BMPR1B | 2.35510934 |
8 | VRK2 | 2.33017571 |
9 | CCNB1 | 2.17498600 |
10 | STK16 | 2.15363319 |
11 | ZAK | 2.09227010 |
12 | NEK1 | 2.07733907 |
13 | PDK2 | 2.03940675 |
14 | WEE1 | 2.02128660 |
15 | MAP3K4 | 1.99564871 |
16 | MKNK2 | 1.92461800 |
17 | CDK19 | 1.86967298 |
18 | PLK4 | 1.83445082 |
19 | CDC7 | 1.79595943 |
20 | FRK | 1.75538603 |
21 | EIF2AK3 | 1.73476412 |
22 | ERBB3 | 1.68143730 |
23 | PLK3 | 1.64510288 |
24 | PLK2 | 1.61393565 |
25 | SRPK1 | 1.54496807 |
26 | MAP3K12 | 1.54352058 |
27 | MKNK1 | 1.54220409 |
28 | MAP2K7 | 1.53641750 |
29 | VRK1 | 1.53446182 |
30 | TNIK | 1.53127484 |
31 | ACVR1B | 1.49759845 |
32 | GRK1 | 1.46248207 |
33 | BCKDK | 1.41878286 |
34 | BRSK2 | 1.41666502 |
35 | MST4 | 1.39359325 |
36 | MAPK13 | 1.35568200 |
37 | PBK | 1.34528134 |
38 | EPHA4 | 1.27500765 |
39 | PLK1 | 1.18339920 |
40 | ADRBK2 | 1.17284820 |
41 | BCR | 1.11238582 |
42 | CSNK1G2 | 1.10301156 |
43 | PINK1 | 1.06011482 |
44 | CSNK1G1 | 1.05731169 |
45 | TAOK3 | 0.99075958 |
46 | CSNK1G3 | 0.97079142 |
47 | DYRK2 | 0.94842026 |
48 | FLT3 | 0.89212686 |
49 | CASK | 0.88118434 |
50 | NME1 | 0.87873353 |
51 | TLK1 | 0.85162708 |
52 | ATR | 0.83966222 |
53 | TAF1 | 0.81578110 |
54 | PAK3 | 0.80425939 |
55 | DYRK3 | 0.78892922 |
56 | TTK | 0.78810818 |
57 | TSSK6 | 0.78612946 |
58 | AKT3 | 0.78012758 |
59 | AURKB | 0.73075207 |
60 | STK39 | 0.72796092 |
61 | OBSCN | 0.70724724 |
62 | BRSK1 | 0.69973309 |
63 | PRKCG | 0.69809675 |
64 | CSNK1A1L | 0.64860824 |
65 | NEK2 | 0.62252362 |
66 | TIE1 | 0.61597647 |
67 | MINK1 | 0.60070292 |
68 | STK3 | 0.58515901 |
69 | MARK3 | 0.56063606 |
70 | ATM | 0.54659733 |
71 | RPS6KA4 | 0.54116542 |
72 | CHEK2 | 0.53175065 |
73 | PRKCI | 0.53051716 |
74 | PRKCE | 0.51530071 |
75 | WNK4 | 0.50370105 |
76 | EIF2AK2 | 0.50269992 |
77 | CSNK2A1 | 0.49477236 |
78 | TGFBR1 | 0.49038563 |
79 | CSNK1A1 | 0.47496671 |
80 | CDK8 | 0.46183007 |
81 | STK38L | 0.43599782 |
82 | PNCK | 0.43420382 |
83 | CSNK2A2 | 0.43302843 |
84 | OXSR1 | 0.41665082 |
85 | RPS6KA5 | 0.40447225 |
86 | INSRR | 0.40031026 |
87 | TEC | 0.37269810 |
88 | MUSK | 0.36372612 |
89 | CHEK1 | 0.33754743 |
90 | PIM2 | 0.33519599 |
91 | PKN1 | 0.32881230 |
92 | MAP2K4 | 0.29927671 |
93 | TXK | 0.29751192 |
94 | CAMK2A | 0.28534607 |
95 | PRKACA | 0.27246220 |
96 | PRKACB | 0.25581497 |
97 | GRK7 | 0.25472452 |
98 | LIMK1 | 0.24999736 |
99 | CAMK2D | 0.24714001 |
100 | MYLK | 0.24300571 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 3.59226001 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.54339122 |
3 | Parkinsons disease_Homo sapiens_hsa05012 | 3.11263512 |
4 | Protein export_Homo sapiens_hsa03060 | 3.00766429 |
5 | Mismatch repair_Homo sapiens_hsa03430 | 2.84516340 |
6 | Homologous recombination_Homo sapiens_hsa03440 | 2.84263015 |
7 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.65708419 |
8 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.62439847 |
9 | RNA polymerase_Homo sapiens_hsa03020 | 2.45758388 |
10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.26883869 |
11 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.18361569 |
12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.14617401 |
13 | DNA replication_Homo sapiens_hsa03030 | 2.09620762 |
14 | Ribosome_Homo sapiens_hsa03010 | 2.08886040 |
15 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.07793249 |
16 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.05696444 |
17 | Base excision repair_Homo sapiens_hsa03410 | 2.02489987 |
18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.97716521 |
19 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.97413728 |
20 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.91709702 |
21 | Alzheimers disease_Homo sapiens_hsa05010 | 1.86164908 |
22 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.83130950 |
23 | RNA degradation_Homo sapiens_hsa03018 | 1.68092287 |
24 | RNA transport_Homo sapiens_hsa03013 | 1.61950803 |
25 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.59455742 |
26 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.59217395 |
27 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.54224515 |
28 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.53332998 |
29 | Phototransduction_Homo sapiens_hsa04744 | 1.49172836 |
30 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.48043635 |
31 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.46786852 |
32 | Spliceosome_Homo sapiens_hsa03040 | 1.42757790 |
33 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.36989245 |
34 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.30688411 |
35 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.28456304 |
36 | Purine metabolism_Homo sapiens_hsa00230 | 1.18434299 |
37 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.16449455 |
38 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.13102820 |
39 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.11277737 |
40 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.09821490 |
41 | Peroxisome_Homo sapiens_hsa04146 | 1.07889702 |
42 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.05456149 |
43 | Cell cycle_Homo sapiens_hsa04110 | 0.99622490 |
44 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.97880612 |
45 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.89615857 |
46 | Metabolic pathways_Homo sapiens_hsa01100 | 0.88665747 |
47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.85368936 |
48 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.81846265 |
49 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.81824681 |
50 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.79332629 |
51 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.75254578 |
52 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.75099713 |
53 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.73933879 |
54 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.73594037 |
55 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.72901409 |
56 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.72271897 |
57 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.70383623 |
58 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.69102147 |
59 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.68842853 |
60 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.67900886 |
61 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.66843199 |
62 | Carbon metabolism_Homo sapiens_hsa01200 | 0.65055636 |
63 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.63079523 |
64 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.62541367 |
65 | Olfactory transduction_Homo sapiens_hsa04740 | 0.59344350 |
66 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.54865699 |
67 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.53616132 |
68 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.53464768 |
69 | Nicotine addiction_Homo sapiens_hsa05033 | 0.52455656 |
70 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.51575395 |
71 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.51484848 |
72 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.49269926 |
73 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.48099407 |
74 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.45781536 |
75 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.45460774 |
76 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.45429013 |
77 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.45211905 |
78 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.44222099 |
79 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.44129968 |
80 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.43640582 |
81 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.42339915 |
82 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.41825334 |
83 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.41453075 |
84 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.40214777 |
85 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.39798213 |
86 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.39466203 |
87 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.38048887 |
88 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.37888421 |
89 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.37682751 |
90 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.36103553 |
91 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.36052335 |
92 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.34060306 |
93 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.33327609 |
94 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.32787279 |
95 | Lysine degradation_Homo sapiens_hsa00310 | 0.29586021 |
96 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.27720236 |
97 | Sulfur relay system_Homo sapiens_hsa04122 | 0.26757000 |
98 | Circadian rhythm_Homo sapiens_hsa04710 | 0.24777719 |
99 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.24300322 |
100 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.23563791 |