STAG3L5P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gamma-delta T cell differentiation (GO:0045586)4.93471061
2histone H3-K4 trimethylation (GO:0080182)4.35968190
3negative T cell selection (GO:0043383)4.35710083
4negative thymic T cell selection (GO:0045060)4.34075338
5regulation of gamma-delta T cell activation (GO:0046643)4.31125837
6positive regulation of gamma-delta T cell activation (GO:0046645)4.29920102
7positive regulation of granulocyte differentiation (GO:0030854)4.24579998
8positive regulation of CREB transcription factor activity (GO:0032793)3.89833479
9positive T cell selection (GO:0043368)3.70102072
10positive thymic T cell selection (GO:0045059)3.58194939
11Peyers patch development (GO:0048541)3.55728862
12mucosal-associated lymphoid tissue development (GO:0048537)3.55728862
13thymic T cell selection (GO:0045061)3.55244749
14histone H3-K9 methylation (GO:0051567)3.53875705
15histone H3-K9 modification (GO:0061647)3.52636105
16negative regulation of cell killing (GO:0031342)3.45626135
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.45626135
18regulation of B cell receptor signaling pathway (GO:0050855)3.45078625
19T cell selection (GO:0045058)3.44494991
20negative regulation of translation, ncRNA-mediated (GO:0040033)3.39470366
21regulation of translation, ncRNA-mediated (GO:0045974)3.39470366
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.39470366
23B cell receptor signaling pathway (GO:0050853)3.37013085
24histone H3-K36 demethylation (GO:0070544)3.29758718
25activated T cell proliferation (GO:0050798)3.26550531
26behavioral response to nicotine (GO:0035095)3.20150080
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.19296068
28peptidyl-lysine trimethylation (GO:0018023)3.18620645
29cellular response to ethanol (GO:0071361)3.18093300
30histone H3-K4 methylation (GO:0051568)3.15906667
31regulation of granulocyte differentiation (GO:0030852)3.12965953
32peptidyl-lysine methylation (GO:0018022)3.10950266
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10322280
34L-fucose catabolic process (GO:0042355)3.09957769
35fucose catabolic process (GO:0019317)3.09957769
36L-fucose metabolic process (GO:0042354)3.09957769
37neural tube formation (GO:0001841)3.08197356
38cellular response to interleukin-15 (GO:0071350)3.06868796
39protein K48-linked deubiquitination (GO:0071108)3.06652102
40regulation of histone H3-K27 methylation (GO:0061085)3.04625657
41response to interleukin-15 (GO:0070672)3.02548084
42cellular response to exogenous dsRNA (GO:0071360)2.99000524
43monoubiquitinated protein deubiquitination (GO:0035520)2.96948010
44mannose metabolic process (GO:0006013)2.95661023
45histone lysine methylation (GO:0034968)2.94762132
46phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.93748260
47negative regulation of T cell mediated immunity (GO:0002710)2.86397618
48regulation of memory T cell differentiation (GO:0043380)2.86364921
49interkinetic nuclear migration (GO:0022027)2.86294369
50rRNA catabolic process (GO:0016075)2.85671123
51negative regulation of lymphocyte mediated immunity (GO:0002707)2.81001609
52antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.78658179
53tryptophan metabolic process (GO:0006568)2.74619786
54protein K11-linked deubiquitination (GO:0035871)2.74167742
55positive regulation of developmental pigmentation (GO:0048087)2.72046754
56T-helper cell differentiation (GO:0042093)2.71587008
57CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.71587008
58NAD biosynthetic process (GO:0009435)2.70111678
59T cell migration (GO:0072678)2.68199620
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67981807
61negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.67172072
62oxidative demethylation (GO:0070989)2.66564367
63negative regulation of cAMP-mediated signaling (GO:0043951)2.66128978
64positive regulation of defense response to virus by host (GO:0002230)2.64998106
65indole-containing compound catabolic process (GO:0042436)2.60870720
66indolalkylamine catabolic process (GO:0046218)2.60870720
67tryptophan catabolic process (GO:0006569)2.60870720
68imidazole-containing compound metabolic process (GO:0052803)2.60643077
69S-adenosylmethionine metabolic process (GO:0046500)2.60129323
70drug catabolic process (GO:0042737)2.59905307
71antigen processing and presentation of endogenous antigen (GO:0019883)2.59677618
72CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.58759798
73alpha-beta T cell differentiation (GO:0046632)2.56833281
74negative regulation of immunoglobulin mediated immune response (GO:0002890)2.56465413
75negative regulation of B cell mediated immunity (GO:0002713)2.56465413
76regulation of interleukin-12 biosynthetic process (GO:0045075)2.56340067
77tolerance induction (GO:0002507)2.51056634
78snRNA processing (GO:0016180)2.49612632
79regulation of MHC class I biosynthetic process (GO:0045343)2.48769534
80histone lysine demethylation (GO:0070076)2.47046748
81cerebellar Purkinje cell differentiation (GO:0021702)2.46894535
82exogenous drug catabolic process (GO:0042738)2.46366119
83cellular ketone body metabolic process (GO:0046950)2.45959089
84snRNA transcription (GO:0009301)2.44647186
85negative regulation of adaptive immune response (GO:0002820)2.44605578
86histone methylation (GO:0016571)2.44553956
87positive regulation of mRNA catabolic process (GO:0061014)2.43251693
88purinergic nucleotide receptor signaling pathway (GO:0035590)2.41240445
89CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.40787316
90negative regulation of protein oligomerization (GO:0032460)2.40620867
91histone H4-K16 acetylation (GO:0043984)2.39790323
92positive regulation of histone deacetylation (GO:0031065)2.39684590
93indolalkylamine metabolic process (GO:0006586)2.37861241
94histone demethylation (GO:0016577)2.37777506
95embryonic hemopoiesis (GO:0035162)2.37712755
96alpha-beta T cell activation (GO:0046631)2.37558114
97hepatocyte apoptotic process (GO:0097284)2.37516798
98fatty acid transmembrane transport (GO:1902001)2.37191996
99DNA alkylation (GO:0006305)2.36284803
100DNA methylation (GO:0006306)2.36284803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.36842429
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.98544974
3SCL_19346495_ChIP-Seq_HPC-7_Human2.75094388
4MYC_22102868_ChIP-Seq_BL_Human2.67424178
5RUNX_20019798_ChIP-Seq_JUKART_Human2.60133453
6E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.41708059
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41583306
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30607151
9MYB_26560356_Chip-Seq_TH2_Human2.27922835
10CIITA_25753668_ChIP-Seq_RAJI_Human2.25103634
11DROSHA_22980978_ChIP-Seq_HELA_Human2.23467087
12VDR_21846776_ChIP-Seq_THP-1_Human2.17478345
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15528223
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.14975912
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12217750
16MYB_26560356_Chip-Seq_TH1_Human2.03125695
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.99907113
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.98332696
19ZNF274_21170338_ChIP-Seq_K562_Hela1.97754675
20UTX_26944678_Chip-Seq_JUKART_Human1.97589639
21MAF_26560356_Chip-Seq_TH1_Human1.96907378
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92282470
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91516202
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82083079
25GATA3_27048872_Chip-Seq_THYMUS_Human1.79138816
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77028278
27MAF_26560356_Chip-Seq_TH2_Human1.76915407
28GATA1_22025678_ChIP-Seq_K562_Human1.75517463
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71963533
30ER_23166858_ChIP-Seq_MCF-7_Human1.62031527
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61041472
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59307302
33AR_21572438_ChIP-Seq_LNCaP_Human1.55388031
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53335671
35TCF7_22412390_ChIP-Seq_EML_Mouse1.52081770
36IRF1_19129219_ChIP-ChIP_H3396_Human1.49972535
37GATA3_26560356_Chip-Seq_TH2_Human1.47825725
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.44812957
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44244419
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40846269
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40807004
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39176951
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.38650804
44VDR_24763502_ChIP-Seq_THP-1_Human1.35178413
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.35117265
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34476673
47ERA_21632823_ChIP-Seq_H3396_Human1.33979706
48SPI1_23127762_ChIP-Seq_K562_Human1.32880388
49NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32581384
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30041841
51GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28849255
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.28815634
53KDM2B_26808549_Chip-Seq_DND41_Human1.27869770
54P68_20966046_ChIP-Seq_HELA_Human1.26468262
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26384010
56BCL6_27268052_Chip-Seq_Bcells_Human1.26328065
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26149005
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24886239
59P300_27268052_Chip-Seq_Bcells_Human1.24196928
60BCOR_27268052_Chip-Seq_Bcells_Human1.21733613
61WDR5_24793694_ChIP-Seq_LNCAP_Human1.20412781
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20202607
63PHF8_20622854_ChIP-Seq_HELA_Human1.18397049
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.18142934
65KDM5A_27292631_Chip-Seq_BREAST_Human1.15835704
66SMC4_20622854_ChIP-Seq_HELA_Human1.15145331
67E2F1_20622854_ChIP-Seq_HELA_Human1.13538810
68TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.12330982
69RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12113199
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11657774
71OCT4_19829295_ChIP-Seq_ESCs_Human1.11197482
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11134005
73RUNX1_27514584_Chip-Seq_MCF-7_Human1.09600245
74OCT4_20526341_ChIP-Seq_ESCs_Human1.09533351
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09023401
76RAC3_21632823_ChIP-Seq_H3396_Human1.08784742
77GATA1_19941826_ChIP-Seq_K562_Human1.08102682
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05485946
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05282148
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.03294848
81SPI1_23547873_ChIP-Seq_NB4_Human1.00986795
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.00915393
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00516636
84IGF1R_20145208_ChIP-Seq_DFB_Human1.00440837
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00326290
86STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99937159
87TP53_22573176_ChIP-Seq_HFKS_Human0.98233991
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.96830932
89BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.96823877
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96776180
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96372818
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95879027
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95196383
94STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94721259
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.94553704
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93917278
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92988945
98GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89585543
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89068760
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.88685984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.51687333
2MP0000569_abnormal_digit_pigmentation2.86196485
3MP0002009_preneoplasia2.76768461
4MP0001800_abnormal_humoral_immune2.55993025
5MP0004381_abnormal_hair_follicle2.41131193
6MP0001986_abnormal_taste_sensitivity2.33093816
7MP0003646_muscle_fatigue2.26772737
8MP0001835_abnormal_antigen_presentation2.24151698
9MP0001873_stomach_inflammation2.16477027
10MP0000685_abnormal_immune_system2.13438245
11MP0005360_urolithiasis2.09036188
12MP0005671_abnormal_response_to1.93008060
13MP0008961_abnormal_basal_metabolism1.92577079
14MP0002396_abnormal_hematopoietic_system1.89058304
15MP0005075_abnormal_melanosome_morpholog1.85269825
16MP0002723_abnormal_immune_serum1.84290603
17MP0003436_decreased_susceptibility_to1.81627910
18MP0001790_abnormal_immune_system1.81452485
19MP0005387_immune_system_phenotype1.81452485
20MP0003252_abnormal_bile_duct1.79233057
21MP0002420_abnormal_adaptive_immunity1.77101404
22MP0001819_abnormal_immune_cell1.73848536
23MP0004043_abnormal_pH_regulation1.72767914
24MP0002928_abnormal_bile_duct1.72265037
25MP0002166_altered_tumor_susceptibility1.72023864
26MP0002138_abnormal_hepatobiliary_system1.70031402
27MP0004130_abnormal_muscle_cell1.69783863
28MP0002398_abnormal_bone_marrow1.68346138
29MP0002452_abnormal_antigen_presenting1.64712051
30MP0000703_abnormal_thymus_morphology1.59885500
31MP0003183_abnormal_peptide_metabolism1.59002833
32MP0000716_abnormal_immune_system1.58164195
33MP0008057_abnormal_DNA_replication1.57239452
34MP0003724_increased_susceptibility_to1.56610471
35MP0008875_abnormal_xenobiotic_pharmacok1.52947974
36MP0000689_abnormal_spleen_morphology1.49390425
37MP0008995_early_reproductive_senescence1.47247510
38MP0005000_abnormal_immune_tolerance1.45318321
39MP0005025_abnormal_response_to1.45285974
40MP0005083_abnormal_biliary_tract1.44515619
41MP0002722_abnormal_immune_system1.43417404
42MP0008872_abnormal_physiological_respon1.42996267
43MP0002405_respiratory_system_inflammati1.41225515
44MP0003195_calcinosis1.39095867
45MP0003866_abnormal_defecation1.38400156
46MP0000015_abnormal_ear_pigmentation1.36538020
47MP0005645_abnormal_hypothalamus_physiol1.31209815
48MP0003172_abnormal_lysosome_physiology1.29787872
49MP0005646_abnormal_pituitary_gland1.29449839
50MP0002419_abnormal_innate_immunity1.25773329
51MP0003787_abnormal_imprinting1.25673793
52MP0005076_abnormal_cell_differentiation1.25621751
53MP0005174_abnormal_tail_pigmentation1.24650878
54MP0002429_abnormal_blood_cell1.21581969
55MP0004147_increased_porphyrin_level1.20362624
56MP0001348_abnormal_lacrimal_gland1.19343695
57MP0003045_fibrosis1.18713492
58MP0002638_abnormal_pupillary_reflex1.18078364
59MP0009115_abnormal_fat_cell1.16764721
60MP0003136_yellow_coat_color1.16201952
61MP0003656_abnormal_erythrocyte_physiolo1.15169332
62MP0009278_abnormal_bone_marrow1.15093435
63MP0000383_abnormal_hair_follicle1.15021091
64MP0005310_abnormal_salivary_gland1.14231043
65MP0000427_abnormal_hair_cycle1.11814225
66MP0004808_abnormal_hematopoietic_stem1.08576784
67MP0001501_abnormal_sleep_pattern1.06941895
68MP0002933_joint_inflammation1.03216599
69MP0001502_abnormal_circadian_rhythm1.01101637
70MP0002653_abnormal_ependyma_morphology1.00009465
71MP0002970_abnormal_white_adipose0.98947380
72MP0002006_tumorigenesis0.97272557
73MP0009333_abnormal_splenocyte_physiolog0.95872394
74MP0005266_abnormal_metabolism0.94765144
75MP0002876_abnormal_thyroid_physiology0.93153645
76MP0005448_abnormal_energy_balance0.93120210
77MP0009785_altered_susceptibility_to0.92397610
78MP0010329_abnormal_lipoprotein_level0.91446739
79MP0005551_abnormal_eye_electrophysiolog0.91280351
80MP0005334_abnormal_fat_pad0.90965319
81MP0005171_absent_coat_pigmentation0.88797735
82MP0005085_abnormal_gallbladder_physiolo0.87034932
83MP0000371_diluted_coat_color0.86066912
84MP0005220_abnormal_exocrine_pancreas0.85764681
85MP0010155_abnormal_intestine_physiology0.84565516
86MP0002971_abnormal_brown_adipose0.84233139
87MP0005397_hematopoietic_system_phenotyp0.81456184
88MP0001545_abnormal_hematopoietic_system0.81456184
89MP0004947_skin_inflammation0.80869455
90MP0001764_abnormal_homeostasis0.78232657
91MP0008469_abnormal_protein_level0.75735233
92MP0001845_abnormal_inflammatory_respons0.73451449
93MP0002332_abnormal_exercise_endurance0.73169716
94MP0003786_premature_aging0.72536079
95MP0000609_abnormal_liver_physiology0.72513539
96MP0002822_catalepsy0.72404493
97MP0000470_abnormal_stomach_morphology0.69552310
98MP0002735_abnormal_chemical_nociception0.69172577
99MP0004742_abnormal_vestibular_system0.67698816
100MP0008775_abnormal_heart_ventricle0.67547637

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)3.76686181
2Abnormality of the fingertips (HP:0001211)3.72741934
3Panhypogammaglobulinemia (HP:0003139)3.72374292
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.51377373
5Recurrent fungal infections (HP:0002841)3.26408774
6Severe combined immunodeficiency (HP:0004430)3.22613767
7Stomach cancer (HP:0012126)3.13948578
8Cerebellar dysplasia (HP:0007033)3.06314334
9Abnormality of the renal cortex (HP:0011035)3.01100525
10Abnormality of T cell number (HP:0011839)2.99353950
11T lymphocytopenia (HP:0005403)2.96514277
12Clumsiness (HP:0002312)2.94671734
13Recurrent cutaneous fungal infections (HP:0011370)2.91233500
14Chronic mucocutaneous candidiasis (HP:0002728)2.91233500
15Protruding tongue (HP:0010808)2.88420566
16Abnormality of T cells (HP:0002843)2.86597987
17Colitis (HP:0002583)2.80770001
18Attenuation of retinal blood vessels (HP:0007843)2.71881076
19Congenital stationary night blindness (HP:0007642)2.69079318
20Abnormality of B cell number (HP:0010975)2.68244848
21Gaze-evoked nystagmus (HP:0000640)2.66814230
22Agammaglobulinemia (HP:0004432)2.63714698
23Abnormality of T cell physiology (HP:0011840)2.63631781
24Fair hair (HP:0002286)2.57377865
25Elevated erythrocyte sedimentation rate (HP:0003565)2.55713852
26Progressive cerebellar ataxia (HP:0002073)2.55640308
27Pustule (HP:0200039)2.53676347
28Large for gestational age (HP:0001520)2.50181562
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.43438374
30Hyperventilation (HP:0002883)2.42215253
31Nephronophthisis (HP:0000090)2.41856820
32Type II lissencephaly (HP:0007260)2.40776860
33Renal cortical cysts (HP:0000803)2.39702510
34Thyroiditis (HP:0100646)2.39090538
35Abnormality of the renal medulla (HP:0100957)2.33904167
36Autoimmune hemolytic anemia (HP:0001890)2.33326286
37Inflammation of the large intestine (HP:0002037)2.31837941
38Abnormality of eosinophils (HP:0001879)2.30484281
39Pancreatic cysts (HP:0001737)2.29329927
40Generalized hypopigmentation of hair (HP:0011358)2.29247081
41Granulocytopenia (HP:0001913)2.24380006
42Abnormality of DNA repair (HP:0003254)2.23548500
43Hypochromic anemia (HP:0001931)2.23134458
44Hypoplasia of the thymus (HP:0000778)2.21427800
45Recurrent viral infections (HP:0004429)2.21164697
46Gastrointestinal infarctions (HP:0005244)2.20922869
47Recurrent bronchitis (HP:0002837)2.18672803
48Amelogenesis imperfecta (HP:0000705)2.15047454
49Gastrointestinal inflammation (HP:0004386)2.12896507
50IgG deficiency (HP:0004315)2.11210145
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.09925839
52Meningitis (HP:0001287)2.08022508
53Alveolar cell carcinoma (HP:0006519)2.07256535
54Prominent nose (HP:0000448)2.07161939
55Dysmetric saccades (HP:0000641)2.05726900
56Patellar aplasia (HP:0006443)2.05240596
57Partial agenesis of the corpus callosum (HP:0001338)2.04828309
58Stomatitis (HP:0010280)2.04164817
59Encephalitis (HP:0002383)2.03746106
60Neoplasm of the tracheobronchial system (HP:0100552)1.99558571
61Chronic hepatic failure (HP:0100626)1.96577644
62Eosinophilia (HP:0001880)1.96357816
63Hypoplasia of the pons (HP:0012110)1.96158701
64Abnormality of transition element cation homeostasis (HP:0011030)1.95771418
65Abnormality of the sella turcica (HP:0002679)1.95342799
66Abnormality of the pons (HP:0007361)1.91828572
67Lissencephaly (HP:0001339)1.91421531
68Myositis (HP:0100614)1.89664172
69Aplasia/Hypoplasia of the patella (HP:0006498)1.88840250
70Tubular atrophy (HP:0000092)1.87911521
71J-shaped sella turcica (HP:0002680)1.87430199
72Duplicated collecting system (HP:0000081)1.86964694
73Autoimmune thrombocytopenia (HP:0001973)1.86594640
74Combined immunodeficiency (HP:0005387)1.86096396
75Tachypnea (HP:0002789)1.85295730
76Acute lymphatic leukemia (HP:0006721)1.84871213
77Abnormal drinking behavior (HP:0030082)1.83869418
78Polydipsia (HP:0001959)1.83869418
79Chronic diarrhea (HP:0002028)1.83121550
80Progressive inability to walk (HP:0002505)1.82815775
81Chest pain (HP:0100749)1.82441963
82Ketoacidosis (HP:0001993)1.81784354
83Retrobulbar optic neuritis (HP:0100654)1.81368112
84Optic neuritis (HP:0100653)1.81368112
85Eczematoid dermatitis (HP:0000976)1.81131422
86Progressive microcephaly (HP:0000253)1.81055065
87Abnormality of alanine metabolism (HP:0010916)1.79207900
88Hyperalaninemia (HP:0003348)1.79207900
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79207900
90Mediastinal lymphadenopathy (HP:0100721)1.78595536
91Ketosis (HP:0001946)1.78317023
92Basal cell carcinoma (HP:0002671)1.77906053
93Abnormality of the prostate (HP:0008775)1.77565286
94Abnormality of the nasal septum (HP:0000419)1.75536133
95Prolonged bleeding time (HP:0003010)1.73636109
96Leukocytosis (HP:0001974)1.72417618
97Prostate neoplasm (HP:0100787)1.72057021
98Neonatal hypoglycemia (HP:0001998)1.71189755
99Acute hepatic failure (HP:0006554)1.70924597
100B lymphocytopenia (HP:0010976)1.70290084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.54186042
2TAOK33.50668466
3MAP4K12.88701137
4CDK122.59034228
5TXK2.10939459
6TNK21.97417978
7IRAK41.90047696
8BMPR1B1.89259356
9BRD41.89008175
10TLK11.84624977
11GRK61.82997541
12MAP3K71.81923422
13TRIB31.79298704
14ZAK1.76358049
15SIK21.72372562
16WNK41.64252924
17AKT31.55663529
18BLK1.54872503
19EEF2K1.52544072
20BTK1.51366240
21MAP2K21.49080511
22MAP3K141.40941628
23ICK1.38449994
24IKBKE1.37272675
25ITK1.36373010
26MAPK111.29227375
27SYK1.27483356
28FES1.27421877
29INSRR1.21050050
30IKBKB1.20885776
31KIT1.20277128
32TRPM71.19700177
33MARK31.18485392
34CAMK1D1.12100678
35CAMKK11.09002845
36MAP4K21.07646727
37MAPKAPK31.06301138
38ERN11.05974685
39ZAP701.03357421
40MARK21.03303152
41MAP2K31.03231153
42JAK11.01321676
43TYK21.01004015
44LCK0.98982256
45EPHA30.97931049
46CHUK0.96828779
47CSF1R0.96708600
48FGFR40.95744948
49OXSR10.94086535
50RIPK40.93918523
51JAK30.93339936
52PRKAA20.90843534
53ADRBK20.89552237
54DAPK20.88417332
55MAPK130.86914388
56NEK60.86857041
57TEC0.82478231
58RPS6KA60.81975016
59CAMKK20.80331420
60NLK0.79826070
61WNK10.79101676
62PRKAA10.77398514
63STK110.77280344
64LYN0.76681477
65MAP2K60.76277711
66HCK0.76242294
67MAPK120.76052304
68PIK3CG0.75856660
69STK390.75203684
70ACVR1B0.73044752
71PIK3CA0.71902305
72SIK10.71207280
73TBK10.70611030
74CDK40.70144410
75HIPK20.66664323
76MAP3K130.65532878
77PIM10.65043069
78JAK20.65015281
79MTOR0.63899284
80MAPK150.63811330
81PKN20.58473398
82IRAK10.58101786
83PDK10.57812506
84CAMK1G0.56612955
85RPS6KA50.55728255
86FGFR30.55662575
87CAMK40.53830139
88CDC42BPA0.52697390
89RPS6KB20.51145788
90RPS6KL10.51106585
91RPS6KC10.51106585
92SGK20.50320862
93PRKCQ0.50295012
94MAPK30.49345588
95ATR0.48067335
96MAPK70.47511673
97MAP3K100.47312203
98TESK20.44199977
99STK380.44034300
100PRKCH0.43126960

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.12779599
2ABC transporters_Homo sapiens_hsa020102.75719858
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.01415592
4T cell receptor signaling pathway_Homo sapiens_hsa046601.94937912
5B cell receptor signaling pathway_Homo sapiens_hsa046621.87962395
6Nitrogen metabolism_Homo sapiens_hsa009101.86014590
7Linoleic acid metabolism_Homo sapiens_hsa005911.83671130
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76208152
9Lysine degradation_Homo sapiens_hsa003101.71819437
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.71671753
11Acute myeloid leukemia_Homo sapiens_hsa052211.56108840
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55063516
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.51781038
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39353283
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37484129
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36898498
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.35184664
18Graft-versus-host disease_Homo sapiens_hsa053321.26895891
19Phototransduction_Homo sapiens_hsa047441.25218271
20Dorso-ventral axis formation_Homo sapiens_hsa043201.24618605
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23904285
22Other glycan degradation_Homo sapiens_hsa005111.21943180
23Measles_Homo sapiens_hsa051621.20675294
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20415666
25Asthma_Homo sapiens_hsa053101.17393310
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16340770
27Autoimmune thyroid disease_Homo sapiens_hsa053201.15926022
28Butanoate metabolism_Homo sapiens_hsa006501.13353164
29Regulation of autophagy_Homo sapiens_hsa041401.10094474
30Allograft rejection_Homo sapiens_hsa053301.09221173
31Circadian rhythm_Homo sapiens_hsa047101.08772392
32Insulin resistance_Homo sapiens_hsa049311.08720368
33Non-small cell lung cancer_Homo sapiens_hsa052231.08654744
34Leishmaniasis_Homo sapiens_hsa051401.03109315
35FoxO signaling pathway_Homo sapiens_hsa040681.02411431
36Hematopoietic cell lineage_Homo sapiens_hsa046401.01848044
37Taste transduction_Homo sapiens_hsa047421.01817818
38mTOR signaling pathway_Homo sapiens_hsa041501.00742396
39Caffeine metabolism_Homo sapiens_hsa002321.00681231
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00075034
41Glycerophospholipid metabolism_Homo sapiens_hsa005640.99579442
42Ovarian steroidogenesis_Homo sapiens_hsa049130.99061885
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97677060
44Osteoclast differentiation_Homo sapiens_hsa043800.97298125
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94990838
46Inositol phosphate metabolism_Homo sapiens_hsa005620.92377142
47Herpes simplex infection_Homo sapiens_hsa051680.92321769
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89413509
49Fanconi anemia pathway_Homo sapiens_hsa034600.89187039
50Systemic lupus erythematosus_Homo sapiens_hsa053220.89147599
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85654145
52Staphylococcus aureus infection_Homo sapiens_hsa051500.85572921
53Type II diabetes mellitus_Homo sapiens_hsa049300.85387845
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84766376
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.84402175
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83588012
57TNF signaling pathway_Homo sapiens_hsa046680.82518216
58Platelet activation_Homo sapiens_hsa046110.82495374
59Choline metabolism in cancer_Homo sapiens_hsa052310.82192417
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82008136
61Prolactin signaling pathway_Homo sapiens_hsa049170.80639764
62Ether lipid metabolism_Homo sapiens_hsa005650.80237175
63Selenocompound metabolism_Homo sapiens_hsa004500.79808141
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.79778169
65Histidine metabolism_Homo sapiens_hsa003400.77251739
66VEGF signaling pathway_Homo sapiens_hsa043700.75731836
67Influenza A_Homo sapiens_hsa051640.72918145
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69403319
69Homologous recombination_Homo sapiens_hsa034400.68844516
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.67549487
71Hepatitis C_Homo sapiens_hsa051600.66634928
72Toxoplasmosis_Homo sapiens_hsa051450.65385190
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65044468
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63921657
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63368573
76Olfactory transduction_Homo sapiens_hsa047400.62255490
77Hepatitis B_Homo sapiens_hsa051610.61937402
78Notch signaling pathway_Homo sapiens_hsa043300.61668603
79Type I diabetes mellitus_Homo sapiens_hsa049400.61340398
80Viral carcinogenesis_Homo sapiens_hsa052030.60975373
81Morphine addiction_Homo sapiens_hsa050320.58729526
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58442505
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.58331045
84Tryptophan metabolism_Homo sapiens_hsa003800.57970146
85Calcium signaling pathway_Homo sapiens_hsa040200.56906214
86Tuberculosis_Homo sapiens_hsa051520.56767098
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55762554
88Cholinergic synapse_Homo sapiens_hsa047250.52638319
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52620427
90Arachidonic acid metabolism_Homo sapiens_hsa005900.51167304
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.50662810
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50534244
93Fatty acid biosynthesis_Homo sapiens_hsa000610.50096849
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49032169
95Bile secretion_Homo sapiens_hsa049760.48740249
96Antigen processing and presentation_Homo sapiens_hsa046120.48318959
97MAPK signaling pathway_Homo sapiens_hsa040100.48034570
98Chemokine signaling pathway_Homo sapiens_hsa040620.47894288
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.47350724
100Glycerolipid metabolism_Homo sapiens_hsa005610.46822996

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