STAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.90401234
2Golgi transport vesicle coating (GO:0048200)5.90401234
3COPII vesicle coating (GO:0048208)3.85944559
4cilium or flagellum-dependent cell motility (GO:0001539)3.66203431
5response to pheromone (GO:0019236)3.64155386
6cell wall macromolecule catabolic process (GO:0016998)3.62662567
7establishment of protein localization to Golgi (GO:0072600)3.57625869
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53382088
9sequestering of metal ion (GO:0051238)3.52513125
10protein targeting to Golgi (GO:0000042)3.52367476
11regulation of protein glycosylation (GO:0060049)3.51312602
12regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.43921269
13regulation of cilium movement (GO:0003352)3.40997685
14signal peptide processing (GO:0006465)3.37971601
15ganglion development (GO:0061548)3.32910121
16epithelial cilium movement (GO:0003351)3.29166486
17Golgi to endosome transport (GO:0006895)3.27385838
18cilium movement (GO:0003341)3.25989180
19regulation of type B pancreatic cell apoptotic process (GO:2000674)3.21139261
20regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.17116014
21retrograde transport, vesicle recycling within Golgi (GO:0000301)3.15756254
22ER overload response (GO:0006983)3.09655851
23positive regulation of glycoprotein biosynthetic process (GO:0010560)3.07219840
24interleukin-6-mediated signaling pathway (GO:0070102)3.05702162
25intestinal epithelial cell development (GO:0060576)3.03645359
26wound healing, spreading of epidermal cells (GO:0035313)3.02670726
27cell wall macromolecule metabolic process (GO:0044036)3.00902091
28intra-Golgi vesicle-mediated transport (GO:0006891)3.00517748
29cell adhesion mediated by integrin (GO:0033627)3.00228468
30protein localization to Golgi apparatus (GO:0034067)2.99359756
31retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.98977034
32regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.97604008
33keratinocyte development (GO:0003334)2.95078603
34positive regulation of protein autophosphorylation (GO:0031954)2.93877386
35neural tube formation (GO:0001841)2.93549038
36cilium morphogenesis (GO:0060271)2.89269865
37eosinophil chemotaxis (GO:0048245)2.88278256
38cellular response to ethanol (GO:0071361)2.88055395
39axonemal dynein complex assembly (GO:0070286)2.87733083
40axoneme assembly (GO:0035082)2.86435803
41regulation of SMAD protein import into nucleus (GO:0060390)2.85277024
42modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82657740
43positive regulation by organism of defense response of other organism involved in symbiotic interact2.82657740
44modulation by symbiont of host immune response (GO:0052553)2.82657740
45positive regulation by symbiont of host defense response (GO:0052509)2.82657740
46modulation by symbiont of host defense response (GO:0052031)2.82657740
47modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82657740
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.82569362
49positive regulation of chemokine biosynthetic process (GO:0045080)2.81696678
50positive regulation of SMAD protein import into nucleus (GO:0060391)2.80695580
51UDP-N-acetylglucosamine metabolic process (GO:0006047)2.76715200
52positive regulation of gastrulation (GO:2000543)2.76536522
53monoubiquitinated protein deubiquitination (GO:0035520)2.73553588
54regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.72147996
55membrane budding (GO:0006900)2.70078453
56negative regulation of translational initiation (GO:0045947)2.69969863
57regulation of transforming growth factor beta2 production (GO:0032909)2.68362549
58positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.67835526
59DNA deamination (GO:0045006)2.66930276
60positive regulation of oligodendrocyte differentiation (GO:0048714)2.66633648
61cilium organization (GO:0044782)2.64626932
62regulation of RNA export from nucleus (GO:0046831)2.64581818
63vesicle coating (GO:0006901)2.64324003
64polyol catabolic process (GO:0046174)2.63741009
65import into cell (GO:0098657)2.63292183
66positive regulation of actin filament depolymerization (GO:0030836)2.63246944
67regulation of T cell chemotaxis (GO:0010819)2.60206407
68positive regulation of T cell chemotaxis (GO:0010820)2.60206407
69intraciliary transport (GO:0042073)2.58242152
70inositol phosphate catabolic process (GO:0071545)2.58139074
71iron ion import (GO:0097286)2.57766503
72wound healing, spreading of cells (GO:0044319)2.55765903
73cilium assembly (GO:0042384)2.54868230
74cellular response to hepatocyte growth factor stimulus (GO:0035729)2.54779262
75response to hepatocyte growth factor (GO:0035728)2.54779262
76activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54337314
77type B pancreatic cell development (GO:0003323)2.53750370
78positive regulation of glycoprotein metabolic process (GO:1903020)2.53595536
79regulation of integrin-mediated signaling pathway (GO:2001044)2.52218696
80endoplasmic reticulum unfolded protein response (GO:0030968)2.50993933
81cellular response to vitamin D (GO:0071305)2.50498832
82cellular response to unfolded protein (GO:0034620)2.49606093
83negative regulation of metanephros development (GO:0072217)2.47678540
84interkinetic nuclear migration (GO:0022027)2.47318668
85left/right axis specification (GO:0070986)2.45558141
86positive regulation of chromosome segregation (GO:0051984)2.44736844
87pyrimidine ribonucleoside catabolic process (GO:0046133)2.44327876
88negative regulation of complement activation (GO:0045916)2.44108977
89spindle assembly involved in mitosis (GO:0090307)2.43446333
90positive regulation of nuclease activity (GO:0032075)2.43352965
91macroautophagy (GO:0016236)2.43249566
92photoreceptor cell maintenance (GO:0045494)2.42918303
93sequestering of extracellular ligand from receptor (GO:0035581)2.42592806
94sphingomyelin metabolic process (GO:0006684)2.42552061
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42028533
96regulation of chemokine-mediated signaling pathway (GO:0070099)2.41604790
97positive regulation of phosphatase activity (GO:0010922)2.41312914
98negative regulation of mast cell activation (GO:0033004)2.40867999
99skin morphogenesis (GO:0043589)2.40856628
100eosinophil migration (GO:0072677)2.39866592
101cellular response to topologically incorrect protein (GO:0035967)2.39571475
102retinal cone cell development (GO:0046549)2.39171136
103regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.38890097
104protein K11-linked deubiquitination (GO:0035871)2.37477116
105positive regulation of mitotic sister chromatid separation (GO:1901970)2.37318332
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.37318332
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.37318332
108purine nucleobase biosynthetic process (GO:0009113)2.36510923
109positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.35732554
110positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.35381780
111brain morphogenesis (GO:0048854)2.35333036
112pericardium development (GO:0060039)2.34036981
113endocrine pancreas development (GO:0031018)2.33784293
114positive regulation of autophagy (GO:0010508)2.33698345
115lung lobe morphogenesis (GO:0060463)2.33010981
116neutrophil activation involved in immune response (GO:0002283)2.32985973
117inositol phosphate dephosphorylation (GO:0046855)2.32749869
118phosphorylated carbohydrate dephosphorylation (GO:0046838)2.32749869
119protein localization to cilium (GO:0061512)2.32261181
120positive regulation of DNA-templated transcription, initiation (GO:2000144)2.31898673
121regulation of nuclease activity (GO:0032069)2.31522963
122endosome to melanosome transport (GO:0035646)2.30873644
123endosome to pigment granule transport (GO:0043485)2.30873644
124protein targeting to lysosome (GO:0006622)2.30677257
125establishment of protein localization to vacuole (GO:0072666)2.30677257
126protein targeting to vacuole (GO:0006623)2.30677257
127nucleotide-sugar biosynthetic process (GO:0009226)2.30463019
128glandular epithelial cell development (GO:0002068)2.30020615
129negative regulation of cytosolic calcium ion concentration (GO:0051481)2.29993949
130columnar/cuboidal epithelial cell development (GO:0002066)2.29749884
131epithelial cell-cell adhesion (GO:0090136)2.29630315
132positive regulation of macroautophagy (GO:0016239)2.29530807
133histone mRNA catabolic process (GO:0071044)2.28891460
134ER to Golgi vesicle-mediated transport (GO:0006888)2.27664746
135retinal rod cell development (GO:0046548)2.27529234
136cellular response to vitamin (GO:0071295)2.27421360
137negative regulation of humoral immune response (GO:0002921)2.26985951
138lipid particle organization (GO:0034389)2.26211351
139folic acid transport (GO:0015884)2.26182884
140cytidine metabolic process (GO:0046087)2.26120174
141cytidine catabolic process (GO:0006216)2.26120174
142cytidine deamination (GO:0009972)2.26120174
143magnesium ion transport (GO:0015693)2.25835385
144response to xenobiotic stimulus (GO:0009410)2.25553150
145positive regulation of growth hormone secretion (GO:0060124)2.25444439
146protein retention in ER lumen (GO:0006621)2.24226095
147natural killer cell mediated immunity (GO:0002228)2.23809734
148natural killer cell mediated cytotoxicity (GO:0042267)2.23809734
149pyrimidine-containing compound transmembrane transport (GO:0072531)2.23787549
150acrosome assembly (GO:0001675)2.22923134
151blastocyst development (GO:0001824)2.22720987
152negative regulation of neurological system process (GO:0031645)2.22399472
153glycosphingolipid biosynthetic process (GO:0006688)2.22134787
154retina vasculature morphogenesis in camera-type eye (GO:0061299)2.22046182
155ER-nucleus signaling pathway (GO:0006984)2.22023179
156myelin assembly (GO:0032288)2.21001300
157regulation of hexokinase activity (GO:1903299)2.20882403
158regulation of glucokinase activity (GO:0033131)2.20882403
159negative regulation of axon extension involved in axon guidance (GO:0048843)2.20689166
160peptide hormone processing (GO:0016486)2.20380623
161regulation of cardioblast differentiation (GO:0051890)2.20286496
162cellular component assembly involved in morphogenesis (GO:0010927)2.19183565
163regulation of podosome assembly (GO:0071801)2.19142932
164positive regulation of glycolytic process (GO:0045821)2.17391364
165hippo signaling (GO:0035329)2.17199934
166response to lipoprotein particle (GO:0055094)2.17177250
167negative regulation of neurotransmitter transport (GO:0051589)2.16969052
168dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.16622633
169negative regulation of JAK-STAT cascade (GO:0046426)2.14798521
170microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.14514332
171ectoderm development (GO:0007398)2.13852023
172positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.13726494
173regulation of clathrin-mediated endocytosis (GO:2000369)2.13205601
174negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.12676036
175negative regulation of stem cell proliferation (GO:2000647)2.11857789
176neuron projection extension involved in neuron projection guidance (GO:1902284)2.11728973
177axon extension involved in axon guidance (GO:0048846)2.11728973
178regulation of protein autophosphorylation (GO:0031952)2.11323957
179parental behavior (GO:0060746)2.11167465
180negative regulation of protein activation cascade (GO:2000258)2.10901586
181regulation of establishment of cell polarity (GO:2000114)2.10867421
182positive regulation of transforming growth factor beta production (GO:0071636)2.10711078
183L-fucose catabolic process (GO:0042355)2.10692097
184fucose catabolic process (GO:0019317)2.10692097
185L-fucose metabolic process (GO:0042354)2.10692097
186early endosome to late endosome transport (GO:0045022)2.10359147
187membrane protein ectodomain proteolysis (GO:0006509)2.10219296
188keratan sulfate catabolic process (GO:0042340)2.08661949
189piRNA metabolic process (GO:0034587)2.08255588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.62470164
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.46762963
3GBX2_23144817_ChIP-Seq_PC3_Human2.85090366
4KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.76217999
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.73868662
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.73515127
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.71471812
8TFEB_21752829_ChIP-Seq_HELA_Human2.51973921
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48664211
10CLOCK_20551151_ChIP-Seq_293T_Human2.47055977
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45701324
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44438100
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.42007402
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.35135309
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.31384185
16ELK1_19687146_ChIP-ChIP_HELA_Human2.25209637
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.24644174
18SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.23885669
19* GABP_17652178_ChIP-ChIP_JURKAT_Human2.19586435
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15082703
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13815662
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12632266
23TAF15_26573619_Chip-Seq_HEK293_Human2.12163054
24ZNF274_21170338_ChIP-Seq_K562_Hela2.05351473
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.05217535
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.04171070
27AR_21909140_ChIP-Seq_LNCAP_Human2.03030508
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.01946131
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01761919
30ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.99727190
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88446347
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.88166597
33BRD4_25478319_ChIP-Seq_HGPS_Human1.87728583
34P300_19829295_ChIP-Seq_ESCs_Human1.85621065
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85481148
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85295152
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.85266711
38* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83179297
39SMAD4_21799915_ChIP-Seq_A2780_Human1.81905405
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81308111
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79976365
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.79433223
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.79375322
44* CJUN_26792858_Chip-Seq_BT549_Human1.79324882
45EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.78289020
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.76671385
47VDR_22108803_ChIP-Seq_LS180_Human1.75574250
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.74256371
49* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73872765
50* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73872765
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71499192
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71330747
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70446467
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69931526
55* FUS_26573619_Chip-Seq_HEK293_Human1.68849228
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.68045467
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67558060
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65996004
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.64869580
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64733704
61DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.64183592
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62744030
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.61262474
64* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60664048
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60075287
66STAT3_23295773_ChIP-Seq_U87_Human1.58665135
67* NANOG_18555785_Chip-Seq_ESCs_Mouse1.58159088
68EWS_26573619_Chip-Seq_HEK293_Human1.57089043
69BCAT_22108803_ChIP-Seq_LS180_Human1.55961888
70* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55888527
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51582989
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51350910
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51069427
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.50312166
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.49691778
76CDX2_22108803_ChIP-Seq_LS180_Human1.45979850
77FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45047888
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.44748779
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43613139
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42021717
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.41855017
82* P53_22387025_ChIP-Seq_ESCs_Mouse1.41225286
83* E2F1_18555785_Chip-Seq_ESCs_Mouse1.39420618
84TCF4_23295773_ChIP-Seq_U87_Human1.39253700
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38898162
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.38861259
87NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38600158
88NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38600158
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.38263342
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38050405
91* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37982864
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37882294
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36966751
94* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.35666803
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35373706
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.35080283
97UBF1/2_26484160_Chip-Seq_HMECs_Human1.34900109
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34394104
99SOX2_20726797_ChIP-Seq_SW620_Human1.33818877
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31911269
101CBP_20019798_ChIP-Seq_JUKART_Human1.31911269
102* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31726770
103STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.31157779
104AR_25329375_ChIP-Seq_VCAP_Human1.29960967
105AHR_22903824_ChIP-Seq_MCF-7_Human1.29404435
106* CMYC_18555785_Chip-Seq_ESCs_Mouse1.29282889
107SOX17_20123909_ChIP-Seq_XEN_Mouse1.29102291
108TCF4_22108803_ChIP-Seq_LS180_Human1.28208180
109IRF8_22096565_ChIP-ChIP_GC-B_Human1.27973227
110OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26203740
111* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25493366
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23227015
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22750760
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.22559012
115* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22085376
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21959221
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21747287
118* P300_18555785_Chip-Seq_ESCs_Mouse1.20545262
119* STAT3_18555785_Chip-Seq_ESCs_Mouse1.19781957
120TP53_16413492_ChIP-PET_HCT116_Human1.19459391
121CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19400151
122POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19223617
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.18882768
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18748957
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18106327
126* TP63_23658742_ChIP-Seq_EP156T_Human1.17476205
127EP300_21415370_ChIP-Seq_HL-1_Mouse1.16917519
128* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16757021
129NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15954236
130FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15289383
131HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15213964
132SOX2_18555785_Chip-Seq_ESCs_Mouse1.14760393
133TP53_18474530_ChIP-ChIP_U2OS_Human1.14587963
134IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14284570
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.14232131
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13763698
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13763698
138KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13763698
139SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13307490
140PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13291287
141OCT4_18555785_Chip-Seq_ESCs_Mouse1.13250802
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10966002
143ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10964105
144CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10711833
145* VDR_23849224_ChIP-Seq_CD4+_Human1.10174243
146CHD1_26751641_Chip-Seq_LNCaP_Human1.10060229
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09808709
148PRDM14_20953172_ChIP-Seq_ESCs_Human1.09648206
149* RUNX2_22187159_ChIP-Seq_PCA_Human1.09587188
150JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08783203
151RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08379532
152* NMYC_18555785_Chip-Seq_ESCs_Mouse1.08121666
153ESR1_20079471_ChIP-ChIP_T-47D_Human1.07847742
154EST1_17652178_ChIP-ChIP_JURKAT_Human1.07630072
155KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07345408
156IGF1R_20145208_ChIP-Seq_DFB_Human1.07031978
157MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.06385717
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05538996
159* PU1_27457419_Chip-Seq_LIVER_Mouse1.05486661
160CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05472430
161GATA4_25053715_ChIP-Seq_YYC3_Human1.05070616
162ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04463555
163NANOG_19829295_ChIP-Seq_ESCs_Human1.04302572
164SOX2_19829295_ChIP-Seq_ESCs_Human1.04302572
165JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04169210
166FLI1_21867929_ChIP-Seq_TH2_Mouse1.03911376
167* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03388922
168* SMAD4_21741376_ChIP-Seq_EPCs_Human1.02989849
169* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02679447
170GATA2_21666600_ChIP-Seq_HMVEC_Human1.02480344
171ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02283735
172SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01773696
173IRF8_27001747_Chip-Seq_BMDM_Mouse1.00298873
174CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99270317
175VDR_24787735_ChIP-Seq_THP-1_Human0.97401213
176TP63_19390658_ChIP-ChIP_HaCaT_Human0.95374345
177MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95271347
178STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94556593
179ER_23166858_ChIP-Seq_MCF-7_Human0.93456804
180NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92498448
181P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89023489
182PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.88509384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.40957637
2MP0008438_abnormal_cutaneous_collagen3.53861419
3MP0002877_abnormal_melanocyte_morpholog3.12010832
4MP0005275_abnormal_skin_tensile2.97088280
5MP0005257_abnormal_intraocular_pressure2.91569155
6MP0000427_abnormal_hair_cycle2.44135851
7MP0003183_abnormal_peptide_metabolism2.37819758
8MP0003252_abnormal_bile_duct2.36276165
9MP0008260_abnormal_autophagy2.31510092
10MP0004272_abnormal_basement_membrane2.29380867
11MP0005058_abnormal_lysosome_morphology2.25426303
12MP0002837_dystrophic_cardiac_calcinosis2.08215342
13MP0003705_abnormal_hypodermis_morpholog2.07899412
14MP0002909_abnormal_adrenal_gland2.02918268
15MP0005503_abnormal_tendon_morphology2.00971826
16MP0003566_abnormal_cell_adhesion1.99729980
17MP0005174_abnormal_tail_pigmentation1.94266656
18MP0003724_increased_susceptibility_to1.92828405
19MP0008877_abnormal_DNA_methylation1.90303082
20MP0001542_abnormal_bone_strength1.87501959
21MP0005367_renal/urinary_system_phenotyp1.78502620
22MP0000516_abnormal_urinary_system1.78502620
23MP0003787_abnormal_imprinting1.73778605
24MP0008057_abnormal_DNA_replication1.71810884
25MP0000015_abnormal_ear_pigmentation1.70334901
26MP0001984_abnormal_olfaction1.69937492
27MP0010307_abnormal_tumor_latency1.69677324
28MP0004043_abnormal_pH_regulation1.67693756
29MP0005076_abnormal_cell_differentiation1.65000522
30MP0003045_fibrosis1.63245930
31MP0005171_absent_coat_pigmentation1.59518319
32MP0010234_abnormal_vibrissa_follicle1.59080667
33MP0003950_abnormal_plasma_membrane1.57191316
34MP0010352_gastrointestinal_tract_polyps1.57126146
35MP0004484_altered_response_of1.53802153
36MP0000372_irregular_coat_pigmentation1.51194005
37MP0003693_abnormal_embryo_hatching1.50141307
38MP0009780_abnormal_chondrocyte_physiolo1.49617990
39MP0002168_other_aberrant_phenotype1.49241558
40MP0004264_abnormal_extraembryonic_tissu1.48997451
41MP0002876_abnormal_thyroid_physiology1.43317614
42MP0000733_abnormal_muscle_development1.42305158
43MP0001293_anophthalmia1.41654206
44MP0005623_abnormal_meninges_morphology1.39352974
45MP0005187_abnormal_penis_morphology1.38771931
46MP0000013_abnormal_adipose_tissue1.37996577
47MP0008875_abnormal_xenobiotic_pharmacok1.37528999
48MP0005164_abnormal_response_to1.37509330
49MP0004883_abnormal_blood_vessel1.36526887
50MP0003091_abnormal_cell_migration1.36313970
51MP0005085_abnormal_gallbladder_physiolo1.34986959
52MP0009384_cardiac_valve_regurgitation1.34688930
53MP0001299_abnormal_eye_distance/1.30074954
54MP0005248_abnormal_Harderian_gland1.29291150
55MP0002928_abnormal_bile_duct1.28464101
56MP0003448_altered_tumor_morphology1.27942477
57MP0000627_abnormal_mammary_gland1.25388555
58MP0003172_abnormal_lysosome_physiology1.24961375
59MP0004742_abnormal_vestibular_system1.24495834
60MP0005408_hypopigmentation1.23997638
61MP0002896_abnormal_bone_mineralization1.22117959
62MP0004084_abnormal_cardiac_muscle1.21910776
63MP0001730_embryonic_growth_arrest1.20829279
64MP0003221_abnormal_cardiomyocyte_apopto1.19484093
65MP0001756_abnormal_urination1.16785043
66MP0005551_abnormal_eye_electrophysiolog1.16715015
67MP0003567_abnormal_fetal_cardiomyocyte1.16469732
68MP0005253_abnormal_eye_physiology1.16304001
69MP0004134_abnormal_chest_morphology1.16215052
70MP0001958_emphysema1.15574150
71MP0004957_abnormal_blastocyst_morpholog1.14244323
72MP0000003_abnormal_adipose_tissue1.13902764
73MP0010678_abnormal_skin_adnexa1.12906236
74MP0001533_abnormal_skeleton_physiology1.11542516
75MP0004215_abnormal_myocardial_fiber1.11346928
76MP0003937_abnormal_limbs/digits/tail_de1.10522168
77MP0008007_abnormal_cellular_replicative1.09959473
78MP0001849_ear_inflammation1.09764850
79MP0010386_abnormal_urinary_bladder1.09673526
80MP0005508_abnormal_skeleton_morphology1.09604149
81MP0005084_abnormal_gallbladder_morpholo1.09223307
82MP0003984_embryonic_growth_retardation1.08997956
83MP0000350_abnormal_cell_proliferation1.08735515
84MP0002088_abnormal_embryonic_growth/wei1.08515798
85MP0006054_spinal_hemorrhage1.07670713
86MP0001835_abnormal_antigen_presentation1.06818654
87MP0008775_abnormal_heart_ventricle1.05587001
88MP0002092_abnormal_eye_morphology1.04790500
89MP0001672_abnormal_embryogenesis/_devel1.02973324
90MP0005380_embryogenesis_phenotype1.02973324
91MP0002102_abnormal_ear_morphology1.02359431
92MP0002177_abnormal_outer_ear1.01945614
93MP0000428_abnormal_craniofacial_morphol1.01852041
94MP0003890_abnormal_embryonic-extraembry1.01809399
95MP0002693_abnormal_pancreas_physiology1.01341135
96MP0002160_abnormal_reproductive_system1.00473948
97MP0005023_abnormal_wound_healing1.00365248
98MP0009333_abnormal_splenocyte_physiolog1.00306306
99MP0000465_gastrointestinal_hemorrhage0.99789108
100MP0003111_abnormal_nucleus_morphology0.99451909
101MP0000538_abnormal_urinary_bladder0.99369697
102MP0005395_other_phenotype0.99077726
103MP0008932_abnormal_embryonic_tissue0.98833586
104MP0002166_altered_tumor_susceptibility0.97967075
105MP0002295_abnormal_pulmonary_circulatio0.97653035
106MP0005390_skeleton_phenotype0.97582403
107MP0003119_abnormal_digestive_system0.95756541
108MP0000534_abnormal_ureter_morphology0.95168113
109MP0001243_abnormal_dermal_layer0.93484969
110MP0003195_calcinosis0.92976328
111MP0004947_skin_inflammation0.92810749
112MP0003795_abnormal_bone_structure0.91990549
113MP0005389_reproductive_system_phenotype0.91914634
114MP0006072_abnormal_retinal_apoptosis0.91713303
115MP0000647_abnormal_sebaceous_gland0.91241469
116MP0002060_abnormal_skin_morphology0.90296044
117MP0005379_endocrine/exocrine_gland_phen0.90172597
118MP0001944_abnormal_pancreas_morphology0.88031543
119MP0005310_abnormal_salivary_gland0.86745952
120MP0002998_abnormal_bone_remodeling0.86440672
121MP0001697_abnormal_embryo_size0.86283912
122MP0005621_abnormal_cell_physiology0.85807645
123MP0003279_aneurysm0.84990625
124MP0002653_abnormal_ependyma_morphology0.84787434
125MP0002697_abnormal_eye_size0.84486398
126MP0003453_abnormal_keratinocyte_physiol0.84366491
127MP0002006_tumorigenesis0.84341191
128MP0002234_abnormal_pharynx_morphology0.84146822
129MP0000371_diluted_coat_color0.83970816
130MP0005645_abnormal_hypothalamus_physiol0.83688085
131MP0001324_abnormal_eye_pigmentation0.83248880
132MP0003077_abnormal_cell_cycle0.82748359
133MP0000432_abnormal_head_morphology0.82662660
134MP0005220_abnormal_exocrine_pancreas0.81676389
135MP0002095_abnormal_skin_pigmentation0.81637107
136MP0001765_abnormal_ion_homeostasis0.81436229
137MP0004885_abnormal_endolymph0.80172817
138MP0002086_abnormal_extraembryonic_tissu0.80095527
139MP0002084_abnormal_developmental_patter0.79239996
140MP0003191_abnormal_cellular_cholesterol0.78242781
141MP0003935_abnormal_craniofacial_develop0.77993098
142MP0005197_abnormal_uvea_morphology0.77367549
143MP0002085_abnormal_embryonic_tissue0.76949513
144MP0003011_delayed_dark_adaptation0.76763487
145MP0003868_abnormal_feces_composition0.75519537
146MP0000230_abnormal_systemic_arterial0.75502132
147MP0001286_abnormal_eye_development0.75335459
148MP0003942_abnormal_urinary_system0.74846373
149MP0000383_abnormal_hair_follicle0.74705695
150MP0001881_abnormal_mammary_gland0.74505542
151MP0003936_abnormal_reproductive_system0.74268923
152MP0002138_abnormal_hepatobiliary_system0.73219412
153MP0002736_abnormal_nociception_after0.70912593
154MP0004147_increased_porphyrin_level0.70816531
155MP0006082_CNS_inflammation0.70637383
156MP0004036_abnormal_muscle_relaxation0.69755398
157MP0003828_pulmonary_edema0.68695586
158MP0002136_abnormal_kidney_physiology0.68374054
159MP0001919_abnormal_reproductive_system0.67743680
160MP0002009_preneoplasia0.67318944
161MP0003633_abnormal_nervous_system0.64255269
162MP0002115_abnormal_skeleton_extremities0.63232271
163MP0003943_abnormal_hepatobiliary_system0.62340352
164MP0002332_abnormal_exercise_endurance0.61959721
165MP0009764_decreased_sensitivity_to0.61689096
166MP0005376_homeostasis/metabolism_phenot0.60355169
167MP0002090_abnormal_vision0.59757811
168MP0005332_abnormal_amino_acid0.59499916
169MP0005646_abnormal_pituitary_gland0.59298188
170MP0001501_abnormal_sleep_pattern0.57179405

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.28830296
2Abnormal pancreas size (HP:0012094)4.04047817
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.56997325
4Rhinitis (HP:0012384)3.48094206
5Papillary thyroid carcinoma (HP:0002895)3.44002001
6Osteolytic defects of the hand bones (HP:0009699)3.41420034
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.41420034
8Absent/shortened dynein arms (HP:0200106)3.38556688
9Dynein arm defect of respiratory motile cilia (HP:0012255)3.38556688
10Fair hair (HP:0002286)3.31358459
11Abnormality of midbrain morphology (HP:0002418)3.30515857
12Molar tooth sign on MRI (HP:0002419)3.30515857
13Chronic hepatic failure (HP:0100626)3.08921078
14Abnormal respiratory motile cilium physiology (HP:0012261)3.07602384
15Congenital sensorineural hearing impairment (HP:0008527)3.05719400
16Abnormal ciliary motility (HP:0012262)3.04873806
17Generalized hypopigmentation of hair (HP:0011358)3.04375117
18Abnormal respiratory motile cilium morphology (HP:0005938)3.00835674
19Abnormal respiratory epithelium morphology (HP:0012253)3.00835674
20Pancreatic cysts (HP:0001737)2.99321124
21Pancreatic fibrosis (HP:0100732)2.94406096
22Medial flaring of the eyebrow (HP:0010747)2.89918906
23Wrist flexion contracture (HP:0001239)2.81994736
24Increased cerebral lipofuscin (HP:0011813)2.80350578
25Degeneration of anterior horn cells (HP:0002398)2.77559220
26Abnormality of the anterior horn cell (HP:0006802)2.77559220
27Nephronophthisis (HP:0000090)2.77116274
28Cervical subluxation (HP:0003308)2.75404051
29Increased neuronal autofluorescent lipopigment (HP:0002074)2.74858199
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.68263222
31Abnormality of glycolipid metabolism (HP:0010969)2.66748573
32Abnormality of liposaccharide metabolism (HP:0010968)2.66748573
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.66748573
34Glucose intolerance (HP:0000833)2.65520819
35Breast hypoplasia (HP:0003187)2.65364139
36Absent speech (HP:0001344)2.65350621
37Hyperventilation (HP:0002883)2.62661699
38Thyroid carcinoma (HP:0002890)2.59893225
39Metaphyseal dysplasia (HP:0100255)2.58514590
40Abnormality of the renal medulla (HP:0100957)2.57478319
41Absent frontal sinuses (HP:0002688)2.54416676
42Bronchiectasis (HP:0002110)2.51528864
43Wormian bones (HP:0002645)2.50758907
44True hermaphroditism (HP:0010459)2.49443432
45Tubulointerstitial nephritis (HP:0001970)2.48854375
46Insulin-resistant diabetes mellitus (HP:0000831)2.47810667
47Chronic bronchitis (HP:0004469)2.45761348
48Neoplasm of the tracheobronchial system (HP:0100552)2.43608911
49Hypothermia (HP:0002045)2.42323472
50Mitral stenosis (HP:0001718)2.37732907
51Short nail (HP:0001799)2.37376700
52Congenital primary aphakia (HP:0007707)2.33856507
53Hyperglycemia (HP:0003074)2.29139117
54Hypoplastic labia majora (HP:0000059)2.27991888
55Gait imbalance (HP:0002141)2.27311725
56Ankle contracture (HP:0006466)2.26606246
57Soft skin (HP:0000977)2.26549768
58Poor head control (HP:0002421)2.26368117
59Dysostosis multiplex (HP:0000943)2.26357147
60Abnormality of the renal cortex (HP:0011035)2.26346588
61Vertebral compression fractures (HP:0002953)2.25430831
62Increased corneal curvature (HP:0100692)2.23270782
63Keratoconus (HP:0000563)2.23270782
64Hypokalemic alkalosis (HP:0001949)2.23256166
65Alveolar cell carcinoma (HP:0006519)2.21814567
66Submucous cleft hard palate (HP:0000176)2.20153697
67Widely spaced teeth (HP:0000687)2.20079304
68Gaze-evoked nystagmus (HP:0000640)2.19598951
69Spinal muscular atrophy (HP:0007269)2.17977174
70Nephrogenic diabetes insipidus (HP:0009806)2.17749247
71Methylmalonic acidemia (HP:0002912)2.14216602
72Shallow orbits (HP:0000586)2.14101594
73Macroorchidism (HP:0000053)2.13530889
74Protrusio acetabuli (HP:0003179)2.13459787
75Congenital hepatic fibrosis (HP:0002612)2.12620745
76Autoamputation (HP:0001218)2.11420069
77Disinhibition (HP:0000734)2.10741476
78Abnormality of the labia majora (HP:0012881)2.07703069
79Neoplasm of the adrenal cortex (HP:0100641)2.06525904
80Natal tooth (HP:0000695)2.05892687
81Progressive visual loss (HP:0000529)2.05547139
82Albinism (HP:0001022)2.05423296
83Drooling (HP:0002307)2.03685517
84Persistence of primary teeth (HP:0006335)2.02600660
85Birth length less than 3rd percentile (HP:0003561)2.02329704
86Atrophic scars (HP:0001075)2.01549453
87Bell-shaped thorax (HP:0001591)2.00108300
88Microglossia (HP:0000171)1.97911425
89Portal hypertension (HP:0001409)1.97875355
90Hypoproteinemia (HP:0003075)1.93531805
91Tubulointerstitial abnormality (HP:0001969)1.93504466
92Hyperactive renin-angiotensin system (HP:0000841)1.92888501
93Furrowed tongue (HP:0000221)1.91785678
94Vacuolated lymphocytes (HP:0001922)1.91541789
95Progressive inability to walk (HP:0002505)1.89055764
96Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.88849345
97Abnormal glucose tolerance (HP:0001952)1.88678937
98Excessive salivation (HP:0003781)1.87970911
99Abnormality of the frontal sinuses (HP:0002687)1.87962096
100Broad ribs (HP:0000885)1.87798762
101Facial diplegia (HP:0001349)1.87230190
102Thyroiditis (HP:0100646)1.87219312
103Curly hair (HP:0002212)1.86471049
104Small epiphyses (HP:0010585)1.86254023
105Genital tract atresia (HP:0001827)1.84925881
106Decreased circulating renin level (HP:0003351)1.84522135
107Flat capital femoral epiphysis (HP:0003370)1.83840063
108Postaxial hand polydactyly (HP:0001162)1.83766833
109Renal cortical cysts (HP:0000803)1.82592238
110Abnormality of macrophages (HP:0004311)1.81524106
111Abnormality of the axillary hair (HP:0100134)1.80186906
112Abnormality of secondary sexual hair (HP:0009888)1.80186906
113Cone-rod dystrophy (HP:0000548)1.80044230
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.78835197
115Abnormality of polysaccharide metabolism (HP:0011012)1.78835197
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.78835197
117Aplasia/Hypoplasia of the fovea (HP:0008060)1.78759034
118Hypoplasia of the fovea (HP:0007750)1.78759034
119Segmental peripheral demyelination/remyelination (HP:0003481)1.74603448
120Chronic diarrhea (HP:0002028)1.73503246
121Short clavicles (HP:0000894)1.71611392
122Abnormality of vitamin B metabolism (HP:0004340)1.70852750
123Vaginal atresia (HP:0000148)1.70298731
124Adrenal hypoplasia (HP:0000835)1.69934702
125Cutaneous melanoma (HP:0012056)1.69862059
126Conjunctival telangiectasia (HP:0000524)1.69721406
127Bilateral sensorineural hearing impairment (HP:0008619)1.68387474
128Increased CSF protein (HP:0002922)1.68352719
129Cerebral hypomyelination (HP:0006808)1.68314886
130Rough bone trabeculation (HP:0100670)1.65841588
131Abnormal protein N-linked glycosylation (HP:0012347)1.65410132
132Abnormal protein glycosylation (HP:0012346)1.65410132
133Abnormal glycosylation (HP:0012345)1.65410132
134Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.65410132
135Abnormality of the fovea (HP:0000493)1.65294526
136Unilateral renal agenesis (HP:0000122)1.65195502
137Dilatation of the ascending aorta (HP:0005111)1.64767142
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.64527303
139Fused cervical vertebrae (HP:0002949)1.64063290
140Abnormality of macular pigmentation (HP:0008002)1.64056948
141Severe short stature (HP:0003510)1.63464255
142Tubular atrophy (HP:0000092)1.63459030
143Abnormality of the hepatic vasculature (HP:0006707)1.63015295
144Striae distensae (HP:0001065)1.62936677
145Anhidrosis (HP:0000970)1.62781319
146Bronchitis (HP:0012387)1.62426673
147Abnormality of the metopic suture (HP:0005556)1.62036530
148Entropion (HP:0000621)1.61651442
149Decreased lacrimation (HP:0000633)1.61366603
150Proximal tubulopathy (HP:0000114)1.60729229
151Abnormality of the distal phalanges of the toes (HP:0010182)1.60591456
152Occipital encephalocele (HP:0002085)1.60511109
153Thoracolumbar scoliosis (HP:0002944)1.60378596
154Barrel-shaped chest (HP:0001552)1.60347998
155Hyperaldosteronism (HP:0000859)1.59633890
156Ketoacidosis (HP:0001993)1.59295619
157Vascular tortuosity (HP:0004948)1.59278104
158Oculomotor apraxia (HP:0000657)1.59233876
159Delayed gross motor development (HP:0002194)1.59206103
160Atrophy/Degeneration involving motor neurons (HP:0007373)1.58032587
161Cystic liver disease (HP:0006706)1.57816747
162Prominent metopic ridge (HP:0005487)1.56963537
163Hip dysplasia (HP:0001385)1.56783579
164Urinary glycosaminoglycan excretion (HP:0003541)1.56616178
165Mucopolysacchariduria (HP:0008155)1.56616178
166Genu recurvatum (HP:0002816)1.56216542
167Retrobulbar optic neuritis (HP:0100654)1.56184394
168Optic neuritis (HP:0100653)1.56184394
169Hepatoblastoma (HP:0002884)1.54929524
170Abnormality of the odontoid process (HP:0003310)1.54904764
171Exocrine pancreatic insufficiency (HP:0001738)1.51578136
172Aortic dissection (HP:0002647)1.50930390
173Abnormality of the umbilical cord (HP:0010881)1.50650815
174Choanal stenosis (HP:0000452)1.50275977
175Irregular vertebral endplates (HP:0003301)1.47951842
176Carpal bone hypoplasia (HP:0001498)1.47899128
177Coxa valga (HP:0002673)1.47590731
178Disproportionate tall stature (HP:0001519)1.46143786
179Breast aplasia (HP:0100783)1.45639000
180Hematochezia (HP:0002573)1.45595685
181Facial hemangioma (HP:0000329)1.45581096
182Aplasia/Hypoplasia of the macula (HP:0008059)1.45215614
183Advanced eruption of teeth (HP:0006288)1.44712238
184Aplasia/Hypoplasia of the clavicles (HP:0006710)1.43697671
185Aplasia/Hypoplasia of the breasts (HP:0010311)1.43669148
186Disproportionate short-trunk short stature (HP:0003521)1.42252704
187Protruding ear (HP:0000411)1.42223408
188Pectus carinatum (HP:0000768)1.38823796
189Aplasia/Hypoplasia of the tongue (HP:0010295)1.37713544
190Right ventricular cardiomyopathy (HP:0011663)1.36467697
191Alacrima (HP:0000522)1.36126944
192Aortic valve stenosis (HP:0001650)1.36092011

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR3.78428307
2PRPF4B3.62392848
3PBK2.92036242
4AKT32.64415232
5EPHA32.49151786
6ERBB32.44856324
7EPHA22.43259265
8MST42.41953613
9TESK12.23567588
10TNIK2.17878450
11CDK122.17522847
12SIK32.15247035
13TAOK22.14430824
14STK392.12786114
15SCYL22.03323081
16LATS11.98497531
17BRSK21.95568722
18ACVR1B1.87342651
19MAP3K21.86447772
20PLK21.78520209
21FRK1.77968591
22MAP3K121.73391859
23PDGFRA1.73192626
24BUB11.71572358
25GRK11.71407923
26OXSR11.68919855
27TRIM281.65845074
28NLK1.61291568
29MET1.59114425
30ERN11.56585837
31UHMK11.53123543
32STK31.51447826
33DYRK21.47239012
34IRAK41.41433457
35PAK31.40876263
36FER1.39639062
37PAK41.39305608
38BMPR1B1.38548436
39IRAK11.38142620
40MAP3K41.37961578
41IRAK21.36901570
42PLK31.36052739
43BMPR21.36052058
44MAP4K21.34627625
45NEK91.34187554
46PASK1.32066375
47LIMK11.31078656
48PNCK1.24552831
49DDR21.23771641
50TXK1.23002085
51PIK3CG1.18626260
52TSSK61.11946030
53IRAK31.09452874
54TAOK31.08923101
55NUAK11.07982233
56MYLK1.07921974
57TRPM71.06993683
58NEK21.05352316
59JAK11.05178962
60RPS6KA41.04572167
61EIF2AK31.03961746
62ADRBK21.00399394
63PTK20.99097308
64BRAF0.98194716
65KSR10.94663630
66SGK20.94433830
67FGFR20.92712172
68PIM20.92676075
69MARK30.91441916
70MTOR0.85851657
71ZAK0.85318244
72WEE10.83742718
73CSNK1G20.83370251
74EIF2AK10.82423423
75PTK2B0.80969809
76FGFR10.79960542
77TBK10.79076258
78KIT0.78581145
79PDGFRB0.78380934
80STK240.77147114
81EPHB10.77117265
82WNK30.76823909
83CSNK1G10.74361585
84CDK90.72031531
85PLK40.70251626
86ERBB40.70132454
87PLK10.69123445
88PINK10.68886712
89CHUK0.66467720
90DAPK20.65209295
91DYRK1B0.64564250
92PRKCI0.64502973
93ABL10.64290168
94FGFR30.63709564
95RPS6KA50.63507186
96INSRR0.63311672
97MAP3K140.62896163
98PAK20.62376345
99PIK3CA0.61303231
100MAP2K70.60162656
101BRSK10.59325327
102PAK10.59188713
103TGFBR20.57788152
104CSNK1G30.55576891
105MARK10.55380584
106CHEK20.54914069
107PDK20.54872452
108FLT30.53723513
109TTK0.53598804
110CDK60.53384523
111STK380.52886141
112ADRBK10.52537432
113MAPK130.51216206
114CAMK1D0.50636319
115NTRK30.50559011
116GRK70.50071814
117GSK3A0.49886496
118MKNK20.49413422
119MAP3K50.48892277
120YES10.48683976
121BRD40.46510697
122AURKA0.46456336
123SGK30.45826969
124TTN0.45264212
125TESK20.45213177
126EPHB20.44609283
127FGFR40.44411729
128CDK70.44279287
129IGF1R0.43301240
130STK100.42850527
131ARAF0.42781059
132CAMKK20.42690268
133MAPKAPK20.42112654
134DYRK1A0.41234779
135TYRO30.39956423
136PRKCQ0.39918579
137MAP2K20.39553564
138SRPK10.39425744
139PRKCE0.39195994
140WNK40.38981562
141PTK60.37619869
142STK38L0.37413012
143TGFBR10.36481158
144TEC0.36196552
145MAP2K40.35680870
146ROCK10.33662635
147MAPKAPK30.33276233
148CSK0.32576472
149PRKG10.32496511
150DYRK30.31775690
151EIF2AK20.31598296
152MELK0.31423522
153CHEK10.31412986
154NEK60.30674625
155IKBKB0.30524938
156PRKACB0.30398020
157CSNK1A1L0.30314344
158MAP3K30.30278373
159CAMK2A0.29793367
160IKBKE0.29753089
161CASK0.29711286
162TAF10.29701130
163ATM0.29424402
164* EGFR0.29043391
165INSR0.28044597
166BLK0.26830716

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049502.83360778
2Protein export_Homo sapiens_hsa030602.25918169
3Lysosome_Homo sapiens_hsa041422.25795688
4Regulation of autophagy_Homo sapiens_hsa041402.17802440
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.15149338
6Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.11727730
7Vitamin B6 metabolism_Homo sapiens_hsa007502.02072321
8Dorso-ventral axis formation_Homo sapiens_hsa043201.98191395
9Propanoate metabolism_Homo sapiens_hsa006401.86287418
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85516568
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.82870231
12Phagosome_Homo sapiens_hsa041451.79431836
13Proteasome_Homo sapiens_hsa030501.74163144
14Histidine metabolism_Homo sapiens_hsa003401.71333790
15Butanoate metabolism_Homo sapiens_hsa006501.62972358
16Legionellosis_Homo sapiens_hsa051341.59804740
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58965272
18Vibrio cholerae infection_Homo sapiens_hsa051101.58119151
19Graft-versus-host disease_Homo sapiens_hsa053321.55122359
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53841080
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50436524
22Type I diabetes mellitus_Homo sapiens_hsa049401.44832476
23p53 signaling pathway_Homo sapiens_hsa041151.41833492
24Linoleic acid metabolism_Homo sapiens_hsa005911.41226839
25Sphingolipid metabolism_Homo sapiens_hsa006001.40553832
26Renal cell carcinoma_Homo sapiens_hsa052111.39627160
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38607691
28Shigellosis_Homo sapiens_hsa051311.37671159
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36761512
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36570129
31Rheumatoid arthritis_Homo sapiens_hsa053231.35576657
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35106392
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34209297
34Circadian rhythm_Homo sapiens_hsa047101.32434682
35RNA transport_Homo sapiens_hsa030131.31830656
36Cell cycle_Homo sapiens_hsa041101.31152502
37beta-Alanine metabolism_Homo sapiens_hsa004101.29926726
38RNA polymerase_Homo sapiens_hsa030201.27846343
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27376873
40Selenocompound metabolism_Homo sapiens_hsa004501.24044787
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23490618
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.23289122
43Antigen processing and presentation_Homo sapiens_hsa046121.22922018
44NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21435114
45Tryptophan metabolism_Homo sapiens_hsa003801.19133014
46Caffeine metabolism_Homo sapiens_hsa002321.18726103
47Epstein-Barr virus infection_Homo sapiens_hsa051691.18660474
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12117542
49Fatty acid degradation_Homo sapiens_hsa000711.10905946
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09740370
51Small cell lung cancer_Homo sapiens_hsa052221.08972806
52MicroRNAs in cancer_Homo sapiens_hsa052061.07975040
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07306768
54Leishmaniasis_Homo sapiens_hsa051401.06366810
55Viral carcinogenesis_Homo sapiens_hsa052031.04749972
56Steroid biosynthesis_Homo sapiens_hsa001001.03443035
57Focal adhesion_Homo sapiens_hsa045101.02884829
58Peroxisome_Homo sapiens_hsa041461.00358153
59Adherens junction_Homo sapiens_hsa045201.00346943
60Proteoglycans in cancer_Homo sapiens_hsa052050.99872962
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99099345
62Chemical carcinogenesis_Homo sapiens_hsa052040.98230311
63Hippo signaling pathway_Homo sapiens_hsa043900.97958103
64TGF-beta signaling pathway_Homo sapiens_hsa043500.97757721
65ECM-receptor interaction_Homo sapiens_hsa045120.97178104
66Collecting duct acid secretion_Homo sapiens_hsa049660.96359942
67Apoptosis_Homo sapiens_hsa042100.95906341
68Renin-angiotensin system_Homo sapiens_hsa046140.95871669
69TNF signaling pathway_Homo sapiens_hsa046680.95838273
70Renin secretion_Homo sapiens_hsa049240.95640620
71Viral myocarditis_Homo sapiens_hsa054160.94898112
72Prostate cancer_Homo sapiens_hsa052150.94274793
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92606104
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92379399
75Bladder cancer_Homo sapiens_hsa052190.92279206
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.91422362
77Toxoplasmosis_Homo sapiens_hsa051450.90996627
78Phototransduction_Homo sapiens_hsa047440.89451955
79Tuberculosis_Homo sapiens_hsa051520.88557256
80Mineral absorption_Homo sapiens_hsa049780.87549967
81Nitrogen metabolism_Homo sapiens_hsa009100.87336191
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86999094
83Hepatitis B_Homo sapiens_hsa051610.86919141
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.86594565
85N-Glycan biosynthesis_Homo sapiens_hsa005100.86429533
86Sulfur metabolism_Homo sapiens_hsa009200.85670934
87ABC transporters_Homo sapiens_hsa020100.85071695
88Retinol metabolism_Homo sapiens_hsa008300.84682589
89Pertussis_Homo sapiens_hsa051330.83965721
90Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83954768
91Staphylococcus aureus infection_Homo sapiens_hsa051500.83723133
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.83118260
93Amoebiasis_Homo sapiens_hsa051460.83110609
94Insulin secretion_Homo sapiens_hsa049110.82329037
95Salmonella infection_Homo sapiens_hsa051320.81881170
96Tight junction_Homo sapiens_hsa045300.81713424
97Malaria_Homo sapiens_hsa051440.80888349
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80735159
99* Jak-STAT signaling pathway_Homo sapiens_hsa046300.78799443
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77691940
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77230755
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.77002800
103Allograft rejection_Homo sapiens_hsa053300.75793003
104Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75692180
105Prion diseases_Homo sapiens_hsa050200.72984232
106Long-term depression_Homo sapiens_hsa047300.72831485
107Influenza A_Homo sapiens_hsa051640.72044773
108Axon guidance_Homo sapiens_hsa043600.71205953
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69686841
110Basal transcription factors_Homo sapiens_hsa030220.68958975
111Osteoclast differentiation_Homo sapiens_hsa043800.68940342
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68512098
113Serotonergic synapse_Homo sapiens_hsa047260.67755762
114Asthma_Homo sapiens_hsa053100.67428441
115Chronic myeloid leukemia_Homo sapiens_hsa052200.66978842
116Salivary secretion_Homo sapiens_hsa049700.66358711
117Folate biosynthesis_Homo sapiens_hsa007900.65430784
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64057461
119Pancreatic secretion_Homo sapiens_hsa049720.63900867
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63256141
121* Endocytosis_Homo sapiens_hsa041440.63037344
122Herpes simplex infection_Homo sapiens_hsa051680.60334558
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60027081
124Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59925289
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59809887
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59464287
127Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59346393
128HTLV-I infection_Homo sapiens_hsa051660.58853565
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58848265
130Hepatitis C_Homo sapiens_hsa051600.58337315
131Prolactin signaling pathway_Homo sapiens_hsa049170.58119915
132Pancreatic cancer_Homo sapiens_hsa052120.57506708
133Endometrial cancer_Homo sapiens_hsa052130.57453262
134mRNA surveillance pathway_Homo sapiens_hsa030150.56973369
135Platelet activation_Homo sapiens_hsa046110.56499730
136Autoimmune thyroid disease_Homo sapiens_hsa053200.55704658
137Arachidonic acid metabolism_Homo sapiens_hsa005900.55620546
138Glycerolipid metabolism_Homo sapiens_hsa005610.55517647
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55114174
140Measles_Homo sapiens_hsa051620.54783589
141Melanoma_Homo sapiens_hsa052180.54161408
142Ether lipid metabolism_Homo sapiens_hsa005650.53960211
143mTOR signaling pathway_Homo sapiens_hsa041500.53919584
144Other glycan degradation_Homo sapiens_hsa005110.53822962
145Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52948551
146Ovarian steroidogenesis_Homo sapiens_hsa049130.52496094
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52355522
148Taste transduction_Homo sapiens_hsa047420.51592858
149ErbB signaling pathway_Homo sapiens_hsa040120.51459035
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.51409468
151Pathways in cancer_Homo sapiens_hsa052000.50776944
152RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50427214
153Oocyte meiosis_Homo sapiens_hsa041140.49384547
154Insulin resistance_Homo sapiens_hsa049310.48420163
155Protein digestion and absorption_Homo sapiens_hsa049740.47378362
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.46401325
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45857204
158FoxO signaling pathway_Homo sapiens_hsa040680.44750066
159Chemokine signaling pathway_Homo sapiens_hsa040620.44421272
160Intestinal immune network for IgA production_Homo sapiens_hsa046720.43707731
161cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40407066
162Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39216267
163Dopaminergic synapse_Homo sapiens_hsa047280.38407099
164Complement and coagulation cascades_Homo sapiens_hsa046100.36351814
165Hematopoietic cell lineage_Homo sapiens_hsa046400.35582180

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