STAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.76167438
2L-phenylalanine catabolic process (GO:0006559)5.76167438
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.56410060
4L-phenylalanine metabolic process (GO:0006558)5.56410060
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.44768823
6aromatic amino acid family catabolic process (GO:0009074)5.24948018
7indole-containing compound catabolic process (GO:0042436)4.90628430
8indolalkylamine catabolic process (GO:0046218)4.90628430
9tryptophan catabolic process (GO:0006569)4.90628430
10kynurenine metabolic process (GO:0070189)4.89330394
11high-density lipoprotein particle remodeling (GO:0034375)4.86821443
12urea cycle (GO:0000050)4.76969554
13urea metabolic process (GO:0019627)4.76969554
14regulation of triglyceride catabolic process (GO:0010896)4.76396879
15sulfur amino acid catabolic process (GO:0000098)4.65134506
16intestinal cholesterol absorption (GO:0030299)4.63600029
17tryptophan metabolic process (GO:0006568)4.60222553
18epoxygenase P450 pathway (GO:0019373)4.59701495
19phospholipid efflux (GO:0033700)4.55525237
20glyoxylate metabolic process (GO:0046487)4.54196919
21regulation of cholesterol esterification (GO:0010872)4.47915581
22bile acid biosynthetic process (GO:0006699)4.46522656
23alpha-linolenic acid metabolic process (GO:0036109)4.42968833
24reverse cholesterol transport (GO:0043691)4.42085239
25nitrogen cycle metabolic process (GO:0071941)4.36415279
26behavioral response to nicotine (GO:0035095)4.36123988
27negative regulation of sterol transport (GO:0032372)4.33119499
28negative regulation of cholesterol transport (GO:0032375)4.33119499
29peptidyl-glutamic acid carboxylation (GO:0017187)4.31423797
30protein carboxylation (GO:0018214)4.31423797
31negative regulation of fibrinolysis (GO:0051918)4.27885928
32regulation of protein activation cascade (GO:2000257)4.26432688
33cysteine metabolic process (GO:0006534)4.24178760
34complement activation, alternative pathway (GO:0006957)4.23985620
35regulation of fibrinolysis (GO:0051917)4.18807234
36positive regulation of triglyceride lipase activity (GO:0061365)4.16266307
37positive regulation of lipoprotein lipase activity (GO:0051006)4.16266307
38regulation of guanylate cyclase activity (GO:0031282)4.14740854
39acylglycerol homeostasis (GO:0055090)4.10912490
40triglyceride homeostasis (GO:0070328)4.10912490
41plasma lipoprotein particle remodeling (GO:0034369)4.07061601
42protein-lipid complex remodeling (GO:0034368)4.07061601
43macromolecular complex remodeling (GO:0034367)4.07061601
44drug metabolic process (GO:0017144)4.03886076
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.03705060
46homocysteine metabolic process (GO:0050667)3.98088302
47regulation of complement activation (GO:0030449)3.96547974
48calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.93942755
49L-fucose catabolic process (GO:0042355)3.93734787
50fucose catabolic process (GO:0019317)3.93734787
51L-fucose metabolic process (GO:0042354)3.93734787
52bile acid metabolic process (GO:0008206)3.93245035
53bile acid and bile salt transport (GO:0015721)3.91802771
54amino-acid betaine metabolic process (GO:0006577)3.91626736
55intestinal absorption (GO:0050892)3.89876952
56cholesterol efflux (GO:0033344)3.86050024
57regulation of cholesterol homeostasis (GO:2000188)3.85011428
58serine family amino acid catabolic process (GO:0009071)3.78479751
59drug catabolic process (GO:0042737)3.73292263
60aromatic amino acid family metabolic process (GO:0009072)3.73058726
61cholesterol homeostasis (GO:0042632)3.72348098
62flavonoid metabolic process (GO:0009812)3.70590928
63phospholipid homeostasis (GO:0055091)3.69553340
64alkaloid metabolic process (GO:0009820)3.68539719
65plasma lipoprotein particle clearance (GO:0034381)3.68172344
66regulation of bile acid biosynthetic process (GO:0070857)3.67160544
67sterol homeostasis (GO:0055092)3.67154352
68lysine catabolic process (GO:0006554)3.62373009
69lysine metabolic process (GO:0006553)3.62373009
70bundle of His cell to Purkinje myocyte communication (GO:0086069)3.61051121
713-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.58550507
72purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.58550507
73positive regulation of respiratory burst (GO:0060267)3.58406693
74cellular glucuronidation (GO:0052695)3.58267498
75plasma lipoprotein particle assembly (GO:0034377)3.53407352
76alpha-amino acid catabolic process (GO:1901606)3.53381993
77arginine metabolic process (GO:0006525)3.51684921
78imidazole-containing compound metabolic process (GO:0052803)3.50861510
79tyrosine metabolic process (GO:0006570)3.49386353
80sulfate transmembrane transport (GO:1902358)3.44165412
81fibrinolysis (GO:0042730)3.42932478
82ethanol oxidation (GO:0006069)3.42860715
83lipoprotein metabolic process (GO:0042157)3.42073291
84phenylpropanoid metabolic process (GO:0009698)3.37565896
85positive regulation of lipid catabolic process (GO:0050996)3.36035845
86positive regulation of guanylate cyclase activity (GO:0031284)3.35527362
87indolalkylamine metabolic process (GO:0006586)3.35373533
88benzene-containing compound metabolic process (GO:0042537)3.35306395
89negative regulation of lipase activity (GO:0060192)3.32783649
90amine catabolic process (GO:0009310)3.30161117
91cellular biogenic amine catabolic process (GO:0042402)3.30161117
92quinone biosynthetic process (GO:1901663)3.29853838
93cellular ketone body metabolic process (GO:0046950)3.28917739
94cellular amino acid catabolic process (GO:0009063)3.28886864
95cellular modified amino acid catabolic process (GO:0042219)3.26453011
96transcytosis (GO:0045056)3.23541495
97glutamate metabolic process (GO:0006536)3.22945267
98ethanol metabolic process (GO:0006067)3.20612973
99positive regulation of triglyceride metabolic process (GO:0090208)3.20364891
100glucuronate metabolic process (GO:0019585)3.20082470
101uronic acid metabolic process (GO:0006063)3.20082470
102ketone body metabolic process (GO:1902224)3.19957781
103acute-phase response (GO:0006953)3.19428144
104positive regulation of fatty acid beta-oxidation (GO:0032000)3.16209759
105protein-lipid complex assembly (GO:0065005)3.15364846
106plasma lipoprotein particle organization (GO:0071827)3.14177801
107very-low-density lipoprotein particle assembly (GO:0034379)3.11539020
108angiotensin maturation (GO:0002003)3.10900141
109carnitine metabolic process (GO:0009437)3.10683432
110auditory receptor cell differentiation (GO:0042491)3.09861385
111water-soluble vitamin biosynthetic process (GO:0042364)3.09780162
112coenzyme catabolic process (GO:0009109)3.09602214
113oxidative demethylation (GO:0070989)3.09264579
114drug transmembrane transport (GO:0006855)3.06655667
115lipid homeostasis (GO:0055088)3.06154144
116vitamin biosynthetic process (GO:0009110)3.05102054
117exogenous drug catabolic process (GO:0042738)3.03794729
118intestinal epithelial cell development (GO:0060576)3.03747805
119arginine catabolic process (GO:0006527)3.03727169
120short-chain fatty acid metabolic process (GO:0046459)3.03333018
121desmosome organization (GO:0002934)3.02810355
122low-density lipoprotein particle remodeling (GO:0034374)3.02285883
123cholesterol transport (GO:0030301)3.02151636
124sterol transport (GO:0015918)3.02151636
125nonribosomal peptide biosynthetic process (GO:0019184)3.01975287
126primary alcohol catabolic process (GO:0034310)3.01721304
127fatty acid oxidation (GO:0019395)3.01018958
128glutathione biosynthetic process (GO:0006750)3.00436418
129fat-soluble vitamin biosynthetic process (GO:0042362)3.00423945
130heme transport (GO:0015886)2.98798330
131regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.98162144
132positive regulation of fatty acid oxidation (GO:0046321)2.97780535
133fucosylation (GO:0036065)2.93478307
134positive regulation of icosanoid secretion (GO:0032305)2.91471289
135sulfate transport (GO:0008272)2.91287786
136positive regulation of fatty acid transport (GO:2000193)2.90594485
137phenol-containing compound catabolic process (GO:0019336)2.85859277
138drug transport (GO:0015893)2.83608664
139digestion (GO:0007586)2.83533459
140phosphatidylserine acyl-chain remodeling (GO:0036150)2.82389236
141quinone metabolic process (GO:1901661)2.79382530
142vitamin transport (GO:0051180)2.76071980
143sulfur compound transport (GO:0072348)2.75489223
144vitamin transmembrane transport (GO:0035461)2.75321086
145regulation of systemic arterial blood pressure by hormone (GO:0001990)2.75168454
146regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.75168454
147endocrine process (GO:0050886)2.75168454
148nucleoside transmembrane transport (GO:1901642)2.73744416
149GDP-mannose metabolic process (GO:0019673)2.72895160
150transepithelial transport (GO:0070633)2.70313682
151oligosaccharide biosynthetic process (GO:0009312)2.68976071
152regulation of cGMP biosynthetic process (GO:0030826)2.66812022
153primary alcohol metabolic process (GO:0034308)2.65326460
154phosphatidylinositol acyl-chain remodeling (GO:0036149)2.64222987
155sulfation (GO:0051923)2.62012870
156omega-hydroxylase P450 pathway (GO:0097267)2.60148452
157multicellular organismal water homeostasis (GO:0050891)2.60027526
158establishment of skin barrier (GO:0061436)2.58965058
159receptor guanylyl cyclase signaling pathway (GO:0007168)2.57719175
160renal system process involved in regulation of blood volume (GO:0001977)2.54624764
161ATP synthesis coupled proton transport (GO:0015986)2.53900098
162energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53900098
163iron coordination entity transport (GO:1901678)2.49895028
164hormone catabolic process (GO:0042447)2.46420898
165negative regulation of keratinocyte proliferation (GO:0010839)2.44789228
166xenobiotic metabolic process (GO:0006805)2.44231526
167regulation of water loss via skin (GO:0033561)2.43401098
168maintenance of gastrointestinal epithelium (GO:0030277)2.43202197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.52244336
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.42602312
3RXR_22158963_ChIP-Seq_LIVER_Mouse6.00992903
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.43730926
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.91954503
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.78831451
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.65632833
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.91216322
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.87766673
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.32454776
11ZNF274_21170338_ChIP-Seq_K562_Hela3.12930284
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.04211657
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.00476342
14VDR_22108803_ChIP-Seq_LS180_Human2.83790878
15* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.21623945
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21412185
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17317400
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88890544
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88491965
20CLOCK_20551151_ChIP-Seq_293T_Human1.86599185
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84229954
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.83736821
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.82238655
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.76872249
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.74349516
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.73669553
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73056200
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71614310
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67595292
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.66155653
31GATA4_25053715_ChIP-Seq_YYC3_Human1.65959738
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.63127116
33GATA1_22025678_ChIP-Seq_K562_Human1.59956477
34ZNF263_19887448_ChIP-Seq_K562_Human1.50550441
35FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49845737
36FOXA1_25329375_ChIP-Seq_VCAP_Human1.49845737
37ERA_21632823_ChIP-Seq_H3396_Human1.49567284
38P53_21459846_ChIP-Seq_SAOS-2_Human1.49201606
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48262365
40NANOG_20526341_ChIP-Seq_ESCs_Human1.48030166
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46652893
42TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45698042
43* SOX2_20726797_ChIP-Seq_SW620_Human1.45660559
44CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43515391
45AR_20517297_ChIP-Seq_VCAP_Human1.42999941
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.42954186
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.40568115
48TAF2_19829295_ChIP-Seq_ESCs_Human1.39539309
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.38491677
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30675106
51* E2F1_20622854_ChIP-Seq_HELA_Human1.29777415
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29198208
53* NCOR_22424771_ChIP-Seq_293T_Human1.27664487
54HOXB7_26014856_ChIP-Seq_BT474_Human1.25659955
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25617550
56CTCF_20526341_ChIP-Seq_ESCs_Human1.24957577
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23247930
58GATA6_25053715_ChIP-Seq_YYC3_Human1.22861721
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21781753
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21391298
61MYC_19829295_ChIP-Seq_ESCs_Human1.21177366
62CTCF_27219007_Chip-Seq_Bcells_Human1.20800449
63ER_23166858_ChIP-Seq_MCF-7_Human1.20532900
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20130087
65SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18732218
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.18570798
67FOXH1_21741376_ChIP-Seq_ESCs_Human1.18288784
68* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18018920
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17959063
70PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.16902099
71* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16543886
72P300_27268052_Chip-Seq_Bcells_Human1.14828009
73OCT4_20526341_ChIP-Seq_ESCs_Human1.14071603
74BCL6_27268052_Chip-Seq_Bcells_Human1.13576448
75YY1_22570637_ChIP-Seq_MALME-3M_Human1.13047281
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12189667
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12103591
78IRF1_19129219_ChIP-ChIP_H3396_Human1.11665406
79EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11430007
80PHF8_20622854_ChIP-Seq_HELA_Human1.11166948
81* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10516786
82SOX2_21211035_ChIP-Seq_LN229_Human1.09897649
83BCOR_27268052_Chip-Seq_Bcells_Human1.09786934
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09174752
85TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07389391
86* RAC3_21632823_ChIP-Seq_H3396_Human1.07371640
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07328480
88SA1_27219007_Chip-Seq_Bcells_Human1.06929631
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.06603231
90ERG_20517297_ChIP-Seq_VCAP_Human1.05284811
91EZH2_27294783_Chip-Seq_ESCs_Mouse1.04951711
92* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03118993
93RACK7_27058665_Chip-Seq_MCF-7_Human1.01575522
94FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00862616
95ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00455470
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00280959
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99767599
98SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99456131
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99410934
100STAT1_20625510_ChIP-Seq_HELA_Human0.98968347
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98321450
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98321450
103KLF5_25053715_ChIP-Seq_YYC3_Human0.98223760
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.96920826
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.95534124
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95225323
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95096645
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92626170
109* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.92244314
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92082403
111PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92007523
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89929085
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89448361
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87854116
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87504361
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87088973
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85780568
118BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83046586
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82903277
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81847573
121AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81571088
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79264288
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78176077
124* TBX20_22080862_ChIP-Seq_HEART_Mouse0.77555043
125* TBX20_22328084_ChIP-Seq_HEART_Mouse0.77555043
126CJUN_26792858_Chip-Seq_BT549_Human0.77177587
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76570215
128LXR_22292898_ChIP-Seq_THP-1_Human0.75432126
129CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74831335
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.74734903
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.74734903
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.74720849
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.74514049
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74290192
135TP63_23658742_ChIP-Seq_EP156T_Human0.73001637
136* CEBPB_22108803_ChIP-Seq_LS180_Human0.72888437
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.72159896
138RXRA_24833708_ChIP-Seq_LIVER_Mouse0.71430830
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.71012966
140HTT_18923047_ChIP-ChIP_STHdh_Human0.69530728
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68314616
142ATF3_27146783_Chip-Seq_COLON_Human0.67670569
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.64915544
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.64251326
145CDX2_22108803_ChIP-Seq_LS180_Human0.63889607
146EGR1_19032775_ChIP-ChIP_M12_Human0.62929367
147GATA2_19941826_ChIP-Seq_K562_Human0.61817687
148HIF1A_21447827_ChIP-Seq_MCF-7_Human0.61355197
149CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.61275060
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61141978
151KAP1_22055183_ChIP-Seq_ESCs_Mouse0.59804811
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59259755
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59139536
154BCAT_22108803_ChIP-Seq_LS180_Human0.57259509
155TP63_22573176_ChIP-Seq_HFKS_Human0.56935250
156JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56178962
157ELK3_25401928_ChIP-Seq_HUVEC_Human0.55519552
158PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55352144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.71477645
2MP0002139_abnormal_hepatobiliary_system5.97629963
3MP0005085_abnormal_gallbladder_physiolo5.18759304
4MP0005365_abnormal_bile_salt4.53390946
5MP0008875_abnormal_xenobiotic_pharmacok3.93257372
6MP0002254_reproductive_system_inflammat3.67049575
7MP0003252_abnormal_bile_duct3.34414702
8MP0001666_abnormal_nutrient_absorption3.18670883
9MP0009840_abnormal_foam_cell2.99366491
10MP0002138_abnormal_hepatobiliary_system2.94935544
11MP0010329_abnormal_lipoprotein_level2.88131784
12MP0003806_abnormal_nucleotide_metabolis2.81792309
13MP0005083_abnormal_biliary_tract2.74310258
14MP0004043_abnormal_pH_regulation2.66359055
15MP0010234_abnormal_vibrissa_follicle2.59597090
16MP0003191_abnormal_cellular_cholesterol2.54564442
17MP0000566_synostosis2.46923703
18MP0004147_increased_porphyrin_level2.39798098
19MP0004019_abnormal_vitamin_homeostasis2.10759932
20MP0003705_abnormal_hypodermis_morpholog2.02899119
21MP0005332_abnormal_amino_acid2.01559213
22MP0008872_abnormal_physiological_respon1.95166573
23MP0002796_impaired_skin_barrier1.92700753
24MP0000609_abnormal_liver_physiology1.78729552
25MP0003183_abnormal_peptide_metabolism1.72632202
26MP0003195_calcinosis1.72230659
27MP0002118_abnormal_lipid_homeostasis1.69354760
28MP0000427_abnormal_hair_cycle1.65224997
29MP0001664_abnormal_digestion1.53064415
30MP0001485_abnormal_pinna_reflex1.51957825
31MP0001765_abnormal_ion_homeostasis1.48017238
32MP0005319_abnormal_enzyme/_coenzyme1.45876095
33MP0004885_abnormal_endolymph1.43796840
34MP0010368_abnormal_lymphatic_system1.42088383
35MP0005451_abnormal_body_composition1.41116119
36MP0004264_abnormal_extraembryonic_tissu1.37656639
37MP0009643_abnormal_urine_homeostasis1.37276946
38MP0002909_abnormal_adrenal_gland1.31221038
39MP0001346_abnormal_lacrimal_gland1.29110753
40MP0005377_hearing/vestibular/ear_phenot1.27315041
41MP0003878_abnormal_ear_physiology1.27315041
42MP0003868_abnormal_feces_composition1.26402981
43MP0002938_white_spotting1.26201677
44MP0003453_abnormal_keratinocyte_physiol1.25891275
45MP0005551_abnormal_eye_electrophysiolog1.23090668
46MP0002876_abnormal_thyroid_physiology1.22708362
47MP0004133_heterotaxia1.18634177
48MP0005167_abnormal_blood-brain_barrier1.17722474
49MP0003283_abnormal_digestive_organ1.16525488
50MP0002277_abnormal_respiratory_mucosa1.14400483
51MP0009764_decreased_sensitivity_to1.14267231
52MP0001764_abnormal_homeostasis1.11697343
53MP0002653_abnormal_ependyma_morphology1.11174919
54MP0005584_abnormal_enzyme/coenzyme_acti1.10662474
55MP0001663_abnormal_digestive_system1.10333171
56MP0005647_abnormal_sex_gland1.09705617
57MP0005646_abnormal_pituitary_gland1.06748504
58MP0003315_abnormal_perineum_morphology1.05509035
59MP0005084_abnormal_gallbladder_morpholo1.04922899
60MP0001873_stomach_inflammation1.04170082
61MP0000678_abnormal_parathyroid_gland1.03299912
62MP0004782_abnormal_surfactant_physiolog1.02712802
63MP0003866_abnormal_defecation1.02577717
64MP0003718_maternal_effect1.02416190
65MP0002060_abnormal_skin_morphology1.01810769
66MP0001881_abnormal_mammary_gland1.01262256
67MP0003879_abnormal_hair_cell0.99971288
68MP0005501_abnormal_skin_physiology0.99492601
69MP0002234_abnormal_pharynx_morphology0.98602897
70MP0002098_abnormal_vibrissa_morphology0.97141345
71MP0000579_abnormal_nail_morphology0.95673377
72MP0000685_abnormal_immune_system0.95625250
73MP0005381_digestive/alimentary_phenotyp0.95207708
74MP0000647_abnormal_sebaceous_gland0.94550724
75MP0003300_gastrointestinal_ulcer0.94464029
76MP0001879_abnormal_lymphatic_vessel0.93590430
77MP0001216_abnormal_epidermal_layer0.93226664
78MP0002822_catalepsy0.93104607
79MP0005645_abnormal_hypothalamus_physiol0.92511150
80MP0009697_abnormal_copulation0.91597477
81MP0003186_abnormal_redox_activity0.90331131
82MP0009379_abnormal_foot_pigmentation0.90162693
83MP0003724_increased_susceptibility_to0.89247153
84MP0004947_skin_inflammation0.88946771
85MP0003011_delayed_dark_adaptation0.88668119
86MP0002736_abnormal_nociception_after0.87507187
87MP0009780_abnormal_chondrocyte_physiolo0.87065733
88MP0000598_abnormal_liver_morphology0.86930876
89MP0000470_abnormal_stomach_morphology0.86391234
90MP0008469_abnormal_protein_level0.85152530
91MP0001188_hyperpigmentation0.85028206
92MP0000462_abnormal_digestive_system0.84622256
93MP0000026_abnormal_inner_ear0.84132224
94MP0010155_abnormal_intestine_physiology0.83622635
95MP0010678_abnormal_skin_adnexa0.83333160
96MP0002166_altered_tumor_susceptibility0.83297237
97MP0009763_increased_sensitivity_to0.81976816
98MP0005636_abnormal_mineral_homeostasis0.80814047
99MP0000537_abnormal_urethra_morphology0.79145118
100MP0005670_abnormal_white_adipose0.79020637
101MP0005408_hypopigmentation0.77773061
102MP0004742_abnormal_vestibular_system0.77375223
103MP0000230_abnormal_systemic_arterial0.77314358
104MP0004381_abnormal_hair_follicle0.75486870
105MP0001853_heart_inflammation0.75442290
106MP0003953_abnormal_hormone_level0.75066826
107MP0001919_abnormal_reproductive_system0.74094098
108MP0000477_abnormal_intestine_morphology0.72880368
109MP0000762_abnormal_tongue_morphology0.72645838
110MP0009785_altered_susceptibility_to0.71978965
111MP0001756_abnormal_urination0.71722502
112MP0002971_abnormal_brown_adipose0.71022749
113MP0002160_abnormal_reproductive_system0.70885261
114MP0002282_abnormal_trachea_morphology0.70711480
115MP0005275_abnormal_skin_tensile0.70024478
116MP0003119_abnormal_digestive_system0.69956527
117MP0002136_abnormal_kidney_physiology0.69511536
118MP0009765_abnormal_xenobiotic_induced0.69509097
119MP0001968_abnormal_touch/_nociception0.68574441
120MP0003436_decreased_susceptibility_to0.67845990
121MP0003638_abnormal_response/metabolism_0.67355789
122MP0009642_abnormal_blood_homeostasis0.67112308
123MP0010352_gastrointestinal_tract_polyps0.65656997
124MP0001905_abnormal_dopamine_level0.64638517
125MP0000538_abnormal_urinary_bladder0.64619272
126MP0010771_integument_phenotype0.64299618
127MP0001348_abnormal_lacrimal_gland0.64230099
128MP0010386_abnormal_urinary_bladder0.63718985
129MP0001501_abnormal_sleep_pattern0.63671085
130MP0008789_abnormal_olfactory_epithelium0.63470432
131MP0000516_abnormal_urinary_system0.63419100
132MP0005367_renal/urinary_system_phenotyp0.63419100
133MP0000377_abnormal_hair_follicle0.63277481
134MP0005389_reproductive_system_phenotype0.63250077
135MP0009053_abnormal_anal_canal0.63233237
136MP0000604_amyloidosis0.63218060
137MP0005220_abnormal_exocrine_pancreas0.61458403
138MP0000467_abnormal_esophagus_morphology0.60918541
139MP0005376_homeostasis/metabolism_phenot0.60534079
140MP0001835_abnormal_antigen_presentation0.60037159
141MP0002009_preneoplasia0.58790033
142MP0005266_abnormal_metabolism0.58005555
143MP0004272_abnormal_basement_membrane0.57869387
144MP0003566_abnormal_cell_adhesion0.57363446
145MP0004130_abnormal_muscle_cell0.56672024
146MP0005334_abnormal_fat_pad0.55857831
147MP0005448_abnormal_energy_balance0.55180675
148MP0000383_abnormal_hair_follicle0.53819233
149MP0005666_abnormal_adipose_tissue0.53678275
150MP0008004_abnormal_stomach_pH0.53549802
151MP0009384_cardiac_valve_regurgitation0.53306242
152MP0001845_abnormal_inflammatory_respons0.53125187
153MP0000249_abnormal_blood_vessel0.52941252
154MP0005023_abnormal_wound_healing0.52749124
155MP0003656_abnormal_erythrocyte_physiolo0.52475224
156MP0001191_abnormal_skin_condition0.52090760
157MP0009931_abnormal_skin_appearance0.51170785

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.10445424
2Deep venous thrombosis (HP:0002625)5.85665824
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.64484679
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.50179208
5Hypobetalipoproteinemia (HP:0003563)5.40005689
6Xanthomatosis (HP:0000991)5.24538811
7Prolonged partial thromboplastin time (HP:0003645)5.04341711
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.66467505
9Decreased circulating renin level (HP:0003351)4.30906956
10Complement deficiency (HP:0004431)4.21106754
11Hypolipoproteinemia (HP:0010981)4.19195178
12Right ventricular cardiomyopathy (HP:0011663)4.16678019
13Hyperlipoproteinemia (HP:0010980)4.16316691
14Epidermoid cyst (HP:0200040)4.01863124
15Fat malabsorption (HP:0002630)3.93856274
16Hyperammonemia (HP:0001987)3.91789693
17Abnormality of the common coagulation pathway (HP:0010990)3.79032482
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.76980361
19Hypoalphalipoproteinemia (HP:0003233)3.71272919
20Joint hemorrhage (HP:0005261)3.68665382
21Hypoglycemic coma (HP:0001325)3.64646205
22Hyperglycinuria (HP:0003108)3.61187629
23Hyperactive renin-angiotensin system (HP:0000841)3.54131644
24Ketosis (HP:0001946)3.50302117
25Hypercholesterolemia (HP:0003124)3.46795168
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.40159688
27Abnormality of renin-angiotensin system (HP:0000847)3.36497565
28Abnormality of the intrinsic pathway (HP:0010989)3.34151573
29Conjugated hyperbilirubinemia (HP:0002908)3.33772530
30Hydroxyprolinuria (HP:0003080)3.28027882
31Abnormality of proline metabolism (HP:0010907)3.28027882
32Esophageal varix (HP:0002040)3.27551493
33Abnormality of glycine metabolism (HP:0010895)3.27185245
34Abnormality of serine family amino acid metabolism (HP:0010894)3.27185245
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24615861
36Abnormality of complement system (HP:0005339)3.22443669
37Hyperglycinemia (HP:0002154)3.19580245
38Alkalosis (HP:0001948)3.19156089
39Vascular calcification (HP:0004934)3.03964618
40Myocardial infarction (HP:0001658)3.01100427
41Abnormality of fatty-acid metabolism (HP:0004359)2.98305769
42Congenital sensorineural hearing impairment (HP:0008527)2.97984300
43Spontaneous abortion (HP:0005268)2.93897539
44Malnutrition (HP:0004395)2.90759764
45Glycosuria (HP:0003076)2.89578875
46Abnormality of urine glucose concentration (HP:0011016)2.89578875
47Steatorrhea (HP:0002570)2.88810988
48Hyperalaninemia (HP:0003348)2.88698001
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.88698001
50Abnormality of alanine metabolism (HP:0010916)2.88698001
51Abnormality of methionine metabolism (HP:0010901)2.86353380
52Abnormality of purine metabolism (HP:0004352)2.84574641
53Abnormality of nucleobase metabolism (HP:0010932)2.83668457
54Abnormality of pyrimidine metabolism (HP:0004353)2.81856090
55Metabolic alkalosis (HP:0200114)2.81266436
56Pancreatic cysts (HP:0001737)2.71956887
57Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.71949584
58Cardiovascular calcification (HP:0011915)2.69826867
59Ketoacidosis (HP:0001993)2.69065634
60Abnormality of midbrain morphology (HP:0002418)2.65852494
61Molar tooth sign on MRI (HP:0002419)2.65852494
62Amyloidosis (HP:0011034)2.55292127
63Congenital stationary night blindness (HP:0007642)2.54336406
64Hyperbilirubinemia (HP:0002904)2.51957265
65True hermaphroditism (HP:0010459)2.50139257
66Hepatocellular carcinoma (HP:0001402)2.47184795
67Systemic lupus erythematosus (HP:0002725)2.41462997
68Abnormal hair laboratory examination (HP:0003328)2.40037484
69Hemorrhage of the eye (HP:0011885)2.39882810
70Tubular atrophy (HP:0000092)2.38993922
71Dicarboxylic aciduria (HP:0003215)2.38535851
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38535851
73Metabolic acidosis (HP:0001942)2.38170457
74Congenital, generalized hypertrichosis (HP:0004540)2.38118466
75Abnormality of vitamin B metabolism (HP:0004340)2.36664049
76Abnormality of the vitamin B12 metabolism (HP:0004341)2.36438474
77Pili torti (HP:0003777)2.35926570
78Amelogenesis imperfecta (HP:0000705)2.35892998
79Gout (HP:0001997)2.34265940
80Abnormality of the renal cortex (HP:0011035)2.31325969
81Acanthocytosis (HP:0001927)2.30393800
82Concave nail (HP:0001598)2.29116890
83Pancreatic fibrosis (HP:0100732)2.28958211
84Delayed CNS myelination (HP:0002188)2.28609354
85Onycholysis (HP:0001806)2.26187823
86Polycythemia (HP:0001901)2.25936036
87Pancreatitis (HP:0001733)2.25417776
88Plantar hyperkeratosis (HP:0007556)2.24039634
89Skin nodule (HP:0200036)2.23269074
90Cholelithiasis (HP:0001081)2.22996066
91Abnormal gallbladder morphology (HP:0012437)2.21624497
92Confusion (HP:0001289)2.21555438
93Ileus (HP:0002595)2.21328098
94Hyperphosphaturia (HP:0003109)2.18725263
95Abnormality of vitamin metabolism (HP:0100508)2.17636490
96Pendular nystagmus (HP:0012043)2.17543184
97Type II lissencephaly (HP:0007260)2.14690874
98Acute encephalopathy (HP:0006846)2.12119263
99Lethargy (HP:0001254)2.10779877
100Hyperaldosteronism (HP:0000859)2.10517190
101Hypoglycemic seizures (HP:0002173)2.09400692
102Cystic liver disease (HP:0006706)2.07122656
103Proximal tubulopathy (HP:0000114)2.06619965
104Fragile nails (HP:0001808)2.05954541
105Autoimmune thrombocytopenia (HP:0001973)2.05704324
106Nephronophthisis (HP:0000090)2.05361671
107Furrowed tongue (HP:0000221)2.04545879
108Abnormality of magnesium homeostasis (HP:0004921)2.04513190
109Chronic hepatic failure (HP:0100626)2.03684181
110Gingival bleeding (HP:0000225)2.02986457
111Rickets (HP:0002748)2.01226599
112Congenital ichthyosiform erythroderma (HP:0007431)2.01089718
113Nephritis (HP:0000123)1.99946175
114Recurrent gram-negative bacterial infections (HP:0005420)1.99050537
115Thrombophlebitis (HP:0004418)1.97891900
116Abnormal urine phosphate concentration (HP:0012599)1.97443891
117Cerebral palsy (HP:0100021)1.96518448
118Abolished electroretinogram (ERG) (HP:0000550)1.95958921
119Hypoplasia of the uterus (HP:0000013)1.95942255
120Abnormality of transition element cation homeostasis (HP:0011030)1.95316504
121Aplasia/hypoplasia of the uterus (HP:0008684)1.92841129
122Late onset (HP:0003584)1.92255207
123Hepatic necrosis (HP:0002605)1.91792107
124Focal segmental glomerulosclerosis (HP:0000097)1.91200182
125Pigmentary retinal degeneration (HP:0001146)1.91020715
126Large for gestational age (HP:0001520)1.90966304
127Glomerulonephritis (HP:0000099)1.88143969
128Abnormality of serum amino acid levels (HP:0003112)1.86866686
129Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86219145
130Microretrognathia (HP:0000308)1.85379876
131Ventricular tachycardia (HP:0004756)1.85365581
132Abnormality of chloride homeostasis (HP:0011422)1.85220296
133Alopecia of scalp (HP:0002293)1.84827386
134Generalized aminoaciduria (HP:0002909)1.84467159
135Abnormality of the renal medulla (HP:0100957)1.84313795
136Abnormal enzyme/coenzyme activity (HP:0012379)1.84122200
137Spastic diplegia (HP:0001264)1.84055031
138Hypokalemia (HP:0002900)1.83735528
139Hyperglycemia (HP:0003074)1.83601626
140Abnormal respiratory epithelium morphology (HP:0012253)1.83407615
141Abnormal respiratory motile cilium morphology (HP:0005938)1.83407615
142Widely patent fontanelles and sutures (HP:0004492)1.83270653
143Chorioretinal atrophy (HP:0000533)1.82773477
144Hyperuricemia (HP:0002149)1.80908638
145Increased purine levels (HP:0004368)1.80908638
146Cerebral edema (HP:0002181)1.79757250
147Neonatal onset (HP:0003623)1.79491046
148Abnormality of renal excretion (HP:0011036)1.78103282
149Abnormality of the gallbladder (HP:0005264)1.78050896
150Hypochromic microcytic anemia (HP:0004840)1.78046316
151Abnormality of iron homeostasis (HP:0011031)1.77958989
152Menorrhagia (HP:0000132)1.77680792
153Woolly hair (HP:0002224)1.77590242
154Palmoplantar hyperkeratosis (HP:0000972)1.77434866
155Vomiting (HP:0002013)1.77125428
156Symptomatic seizures (HP:0011145)1.76940640
157Hypertriglyceridemia (HP:0002155)1.76558859
158Stroke (HP:0001297)1.75779221
159Nephrolithiasis (HP:0000787)1.75772157
160Palmar hyperkeratosis (HP:0010765)1.75615113
161Abnormal drinking behavior (HP:0030082)1.75600171
162Polydipsia (HP:0001959)1.75600171
163Mitochondrial inheritance (HP:0001427)1.74239176
164Abnormal cartilage morphology (HP:0002763)1.74233243
165Chronic bronchitis (HP:0004469)1.73667125
166Acute necrotizing encephalopathy (HP:0006965)1.72580840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.87194579
2BCKDK3.85981039
3ERN13.76757218
4MST1R3.51008332
5WNK43.20942955
6FGFR43.20358237
7FRK2.98826106
8MAP3K142.68941231
9SIK12.64680615
10STK392.64571089
11ADRBK22.55305666
12KDR2.38263725
13EPHA22.30547071
14TIE12.22977721
15TLK12.21902019
16MAP3K32.08582926
17MUSK2.07399781
18BMPR1B2.01556920
19TYK22.01093922
20MST42.00820529
21OXSR11.98171412
22RIPK11.85265584
23EPHB11.83264635
24MAP3K121.75380078
25VRK21.73516913
26INSRR1.70513307
27CASK1.68630623
28MAP4K21.63491129
29NME11.62283549
30TBK11.60151205
31LATS11.58299854
32EPHB21.57899959
33MAP2K21.54930280
34WNK31.52953743
35ERBB41.43865912
36PINK11.42128507
37MET1.41805064
38FER1.37482433
39PRKCI1.35505681
40PRKAA21.32203564
41MAP3K71.32110732
42PIK3CG1.31272024
43MAP2K61.31216240
44TGFBR21.31010608
45MYLK1.30085905
46EPHA31.27300759
47* PTK61.25089747
48MAP3K21.23349744
49TAOK31.22870285
50ZAK1.22374471
51CHUK1.20651770
52MAP2K31.17844297
53NEK91.13238873
54ADRBK11.11982109
55PTK21.11831662
56AKT31.10626478
57PIM21.09512962
58MAPKAPK31.09473392
59TRIB31.07891394
60JAK11.06303268
61DYRK1B1.06214795
62PKN21.06150351
63FLT31.05577370
64IKBKB1.03859468
65IKBKE1.03519520
66DYRK21.02850747
67BCR1.02790282
68STK161.00830930
69MAPK110.99280704
70LMTK20.99112049
71NUAK10.97493501
72GRK10.97378002
73FGFR30.96677073
74MAPK150.95870962
75PIK3CA0.95365525
76TESK20.86785780
77MAP3K110.86613493
78IRAK30.84583988
79LRRK20.83058126
80JAK30.81053398
81MAP3K130.80548526
82MAP2K70.80431600
83PAK30.78709746
84LIMK10.78232258
85ERBB20.76516538
86MAPK130.72224757
87MAP3K10.71145774
88EPHA40.70661907
89PRKCE0.70021554
90TGFBR10.69747512
91CSK0.68927096
92PRKG20.68087698
93NLK0.66429218
94CSNK1A10.65631633
95STK100.64785549
96STK38L0.64719216
97TTN0.63314790
98GSK3A0.63003045
99* JAK20.62970877
100MAP2K10.62911788
101TESK10.62827337
102FGFR20.62358132
103TNIK0.60638577
104CDK60.60270431
105ABL20.57698704
106PRKAA10.57038199
107TXK0.56892267
108VRK10.56390419
109PDK20.54683309
110ICK0.52511692
111MATK0.52094550
112GRK60.50942211
113PRKCA0.50527817
114PHKG20.50382922
115PHKG10.50382922
116TRIM280.50128833
117NTRK30.49428899
118IRAK10.49367590
119PRKCG0.49133794
120MAPKAPK50.48102729
121DAPK20.46729284
122BMX0.44738870
123TRPM70.43721240
124PRKACA0.42697763
125MAPK120.42505361
126CAMK2D0.42202914
127PRKCZ0.40591816
128MAP2K40.38832917
129RPS6KA50.38764496
130STK30.38741442
131PRKACG0.38445742
132MAP3K40.36975259
133ARAF0.36777505
134MAPKAPK20.36110350
135CAMK2G0.35692060
136RPS6KB20.35585838
137PRKCD0.35549176
138IGF1R0.35450431
139PRKD20.35260441
140MAP3K100.33931952
141PRKCQ0.33674096
142STK240.31939150
143BMPR20.30935413
144RPS6KA60.30808732
145RPS6KA10.29385409
146TAF10.28910744
147EGFR0.28686482
148ILK0.26424018
149RPS6KA20.24265816
150CSNK2A10.17887102
151CSNK1G30.17433792

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.82047416
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.58603381
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17799381
4Arginine biosynthesis_Homo sapiens_hsa002202.93095750
5Nitrogen metabolism_Homo sapiens_hsa009102.85073037
6Tryptophan metabolism_Homo sapiens_hsa003802.67028481
7Fatty acid degradation_Homo sapiens_hsa000712.56346370
8Complement and coagulation cascades_Homo sapiens_hsa046102.45285554
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28194176
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24589128
11Fat digestion and absorption_Homo sapiens_hsa049752.19987511
12Histidine metabolism_Homo sapiens_hsa003402.19219084
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.18662953
14Caffeine metabolism_Homo sapiens_hsa002322.17022473
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15433986
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10633893
17PPAR signaling pathway_Homo sapiens_hsa033201.98026160
18Sulfur metabolism_Homo sapiens_hsa009201.92590382
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92582466
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92423478
21Chemical carcinogenesis_Homo sapiens_hsa052041.92061831
22Peroxisome_Homo sapiens_hsa041461.85240213
23Propanoate metabolism_Homo sapiens_hsa006401.76518262
24Phenylalanine metabolism_Homo sapiens_hsa003601.75672002
25Retinol metabolism_Homo sapiens_hsa008301.68292326
26Fatty acid metabolism_Homo sapiens_hsa012121.67305172
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.65548895
28Bile secretion_Homo sapiens_hsa049761.63450363
29Butanoate metabolism_Homo sapiens_hsa006501.60852414
30Staphylococcus aureus infection_Homo sapiens_hsa051501.59948638
31beta-Alanine metabolism_Homo sapiens_hsa004101.58608732
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45366723
33Oxidative phosphorylation_Homo sapiens_hsa001901.42895587
34Vitamin digestion and absorption_Homo sapiens_hsa049771.42809023
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41871806
36Tyrosine metabolism_Homo sapiens_hsa003501.41386048
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41016740
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.39524427
39Starch and sucrose metabolism_Homo sapiens_hsa005001.39225302
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37339544
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.32507367
42Ether lipid metabolism_Homo sapiens_hsa005651.30867945
43Folate biosynthesis_Homo sapiens_hsa007901.27561244
44ABC transporters_Homo sapiens_hsa020101.26883167
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.26693326
46Selenocompound metabolism_Homo sapiens_hsa004501.23290736
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22253147
48Pyruvate metabolism_Homo sapiens_hsa006201.16823884
49Fatty acid elongation_Homo sapiens_hsa000621.08325389
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01951524
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01018616
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96477759
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96312117
54Parkinsons disease_Homo sapiens_hsa050120.95998671
55Carbon metabolism_Homo sapiens_hsa012000.95512842
56Phototransduction_Homo sapiens_hsa047440.95333507
57Arginine and proline metabolism_Homo sapiens_hsa003300.94659318
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92396059
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92277329
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92026712
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.90103543
62Steroid biosynthesis_Homo sapiens_hsa001000.86754756
63Biosynthesis of amino acids_Homo sapiens_hsa012300.85388677
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81934945
65Glycerolipid metabolism_Homo sapiens_hsa005610.80860275
66Ribosome_Homo sapiens_hsa030100.80703841
67Glutathione metabolism_Homo sapiens_hsa004800.80385925
68Linoleic acid metabolism_Homo sapiens_hsa005910.71592151
69Huntingtons disease_Homo sapiens_hsa050160.70025232
70Fatty acid biosynthesis_Homo sapiens_hsa000610.69639313
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67207469
72Sphingolipid metabolism_Homo sapiens_hsa006000.66550443
73Alzheimers disease_Homo sapiens_hsa050100.65285614
74Sulfur relay system_Homo sapiens_hsa041220.63736501
75Lysine degradation_Homo sapiens_hsa003100.60803399
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60517406
77Galactose metabolism_Homo sapiens_hsa000520.60328943
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59549856
79Mineral absorption_Homo sapiens_hsa049780.53763431
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46629518
81Fructose and mannose metabolism_Homo sapiens_hsa000510.45213902
82Pentose phosphate pathway_Homo sapiens_hsa000300.44190070
83Insulin resistance_Homo sapiens_hsa049310.43300051
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.41570747
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39813872
86Renin-angiotensin system_Homo sapiens_hsa046140.38901283
87Cardiac muscle contraction_Homo sapiens_hsa042600.36629113
88Metabolic pathways_Homo sapiens_hsa011000.36019237
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35471970
90Serotonergic synapse_Homo sapiens_hsa047260.32386954
91Protein export_Homo sapiens_hsa030600.31874204
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30037702
93RNA polymerase_Homo sapiens_hsa030200.29205593
94Arachidonic acid metabolism_Homo sapiens_hsa005900.29066267
95Collecting duct acid secretion_Homo sapiens_hsa049660.28551524
96Protein digestion and absorption_Homo sapiens_hsa049740.27045268
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.26809109
98Taste transduction_Homo sapiens_hsa047420.26332168
99Ovarian steroidogenesis_Homo sapiens_hsa049130.26237697
100Nicotine addiction_Homo sapiens_hsa050330.25224342
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24715984
102Proteasome_Homo sapiens_hsa030500.23664077
103Insulin secretion_Homo sapiens_hsa049110.23470619
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20901421
105African trypanosomiasis_Homo sapiens_hsa051430.20697164
106Hepatitis C_Homo sapiens_hsa051600.20660722
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.20132578
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.18996320
109Bladder cancer_Homo sapiens_hsa052190.12202683
110Vitamin B6 metabolism_Homo sapiens_hsa007500.11245432
111Prion diseases_Homo sapiens_hsa050200.10754598
112TNF signaling pathway_Homo sapiens_hsa046680.10627431
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09374372
114Adherens junction_Homo sapiens_hsa045200.08350082
115Amoebiasis_Homo sapiens_hsa051460.07945406
116One carbon pool by folate_Homo sapiens_hsa006700.07761149
117Toxoplasmosis_Homo sapiens_hsa051450.07273940
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06271633
119Allograft rejection_Homo sapiens_hsa053300.05619442
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.04578856
121Pertussis_Homo sapiens_hsa051330.04569708
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.02209147
123Pancreatic secretion_Homo sapiens_hsa049720.01167281
124AMPK signaling pathway_Homo sapiens_hsa04152-8.1605823
125Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.0087830
126Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0039117

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