STAR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* ketone biosynthetic process (GO:0042181)9.16446747
2positive regulation of hormone biosynthetic process (GO:0046886)9.15280352
3adhesion of symbiont to host (GO:0044406)8.50356592
4* cellular response to cadmium ion (GO:0071276)8.30365636
5* androgen metabolic process (GO:0008209)8.29373775
6* cellular response to follicle-stimulating hormone stimulus (GO:0071372)7.77899245
7mating behavior (GO:0007617)6.95870984
8response to methylmercury (GO:0051597)6.94052922
9positive regulation of hormone metabolic process (GO:0032352)6.68176062
10renal system process involved in regulation of blood volume (GO:0001977)6.62804609
11* estrogen metabolic process (GO:0008210)6.62576447
12low-density lipoprotein particle clearance (GO:0034383)6.42213227
13* progesterone metabolic process (GO:0042448)6.28784296
14regulation of male gonad development (GO:2000018)6.13915097
15positive regulation of male gonad development (GO:2000020)6.04306331
16negative regulation of cytosolic calcium ion concentration (GO:0051481)5.94171710
17response to insecticide (GO:0017085)5.82874274
18* response to follicle-stimulating hormone (GO:0032354)5.79670935
19phagocytosis, recognition (GO:0006910)5.70007872
20renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)5.65970914
21positive regulation of steroid biosynthetic process (GO:0010893)5.43868173
22Leydig cell differentiation (GO:0033327)5.07064506
23response to phenylpropanoid (GO:0080184)4.90542757
24positive regulation of systemic arterial blood pressure (GO:0003084)4.88796789
25ovulation (GO:0030728)4.83838981
26* steroid biosynthetic process (GO:0006694)4.74157108
27positive regulation of nitric-oxide synthase activity (GO:0051000)4.71803826
28potassium ion homeostasis (GO:0055075)4.64810720
29* cellular hormone metabolic process (GO:0034754)4.58909335
30* cellular response to antibiotic (GO:0071236)4.57480984
31positive regulation of triglyceride biosynthetic process (GO:0010867)4.57196146
32cholesterol catabolic process (GO:0006707)4.53278529
33sterol catabolic process (GO:0016127)4.53278529
34regulation of female gonad development (GO:2000194)4.47205308
35amyloid precursor protein catabolic process (GO:0042987)4.45794488
36vitamin D metabolic process (GO:0042359)4.43482772
37* cellular response to gonadotropin stimulus (GO:0071371)4.42127262
38response to vitamin E (GO:0033197)4.30962628
39sex differentiation (GO:0007548)4.29795373
40catechol-containing compound biosynthetic process (GO:0009713)4.23841954
41catecholamine biosynthetic process (GO:0042423)4.23841954
42NADP metabolic process (GO:0006739)4.22498256
43detection of molecule of bacterial origin (GO:0032490)4.17251382
44* cellular ketone metabolic process (GO:0042180)4.16385480
45alpha-linolenic acid metabolic process (GO:0036109)4.02183283
46regulation of cholesterol storage (GO:0010885)3.87554368
47regulation of hormone biosynthetic process (GO:0046885)3.81931982
48positive regulation of steroid metabolic process (GO:0045940)3.76441303
49parturition (GO:0007567)3.64119017
50sex determination (GO:0007530)3.57788537
51high-density lipoprotein particle remodeling (GO:0034375)3.56860018
52cholesterol biosynthetic process (GO:0006695)3.46846056
53regulation of transforming growth factor beta2 production (GO:0032909)3.44147733
54* sterol metabolic process (GO:0016125)3.38487691
55regulation of cholesterol homeostasis (GO:2000188)3.38277099
56male genitalia development (GO:0030539)3.36125138
57aggressive behavior (GO:0002118)3.35698280
58reverse cholesterol transport (GO:0043691)3.31502427
59sodium ion homeostasis (GO:0055078)3.31438238
60regulation of triglyceride biosynthetic process (GO:0010866)3.31114984
613-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.30775600
62purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.30775600
63linoleic acid metabolic process (GO:0043651)3.30737160
64response to water (GO:0009415)3.30638608
65multicellular organismal aging (GO:0010259)3.25877056
66* response to mineralocorticoid (GO:0051385)3.24960451
67* response to gonadotropin (GO:0034698)3.20341477
68negative regulation of macrophage differentiation (GO:0045650)3.18711595
69regulation of gonadotropin secretion (GO:0032276)3.15341135
70positive regulation of triglyceride metabolic process (GO:0090208)3.13909818
71* cellular response to toxic substance (GO:0097237)3.13896969
72regulation of cholesterol metabolic process (GO:0090181)3.12899673
73positive regulation of lipid biosynthetic process (GO:0046889)3.11901008
74* hormone metabolic process (GO:0042445)3.11432243
75regulation of female receptivity (GO:0045924)3.10694921
76hemoglobin metabolic process (GO:0020027)3.03923755
77response to lipoprotein particle (GO:0055094)3.03834619
78hippocampus development (GO:0021766)3.00663230
79maintenance of protein location in nucleus (GO:0051457)3.00274425
80glucocorticoid biosynthetic process (GO:0006704)21.8262496
81* C21-steroid hormone biosynthetic process (GO:0006700)21.2950707
82sterol biosynthetic process (GO:0016126)2.97154635
83regulation of systemic arterial blood pressure by hormone (GO:0001990)2.96458412
84regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.96458412
85endocrine process (GO:0050886)2.96458412
86protoporphyrinogen IX biosynthetic process (GO:0006782)2.94881569
87positive regulation of monooxygenase activity (GO:0032770)2.94119508
88glucosamine-containing compound catabolic process (GO:1901072)2.92427005
89sulfation (GO:0051923)2.85119894
90regulation of apoptotic cell clearance (GO:2000425)2.81208697
91* cellular response to metal ion (GO:0071248)2.79967048
92* benzene-containing compound metabolic process (GO:0042537)2.79593256
93regulation of transmission of nerve impulse (GO:0051969)2.77531502
94regulation of triglyceride metabolic process (GO:0090207)2.77087224
95blood vessel endothelial cell migration (GO:0043534)2.77014146
96cholesterol efflux (GO:0033344)2.72426332
97adrenal gland development (GO:0030325)2.70234949
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.68531698
99regulation of hormone metabolic process (GO:0032350)2.67079703
100positive regulation of vascular permeability (GO:0043117)2.66890935
101amyloid precursor protein metabolic process (GO:0042982)2.66679339
102female mating behavior (GO:0060180)2.66644342
103reproductive system development (GO:0061458)2.64525616
104cellular sodium ion homeostasis (GO:0006883)2.60016137
105multi-organism reproductive behavior (GO:0044705)2.56578352
106positive regulation of lipid storage (GO:0010884)2.53099052
107catechol-containing compound metabolic process (GO:0009712)2.51995027
108catecholamine metabolic process (GO:0006584)2.51995027
109plasma lipoprotein particle clearance (GO:0034381)2.50482532
110negative regulation of fatty acid transport (GO:2000192)2.49382579
111* cytokine metabolic process (GO:0042107)2.46586070
112positive regulation of blood pressure (GO:0045777)2.42806981
113* steroid metabolic process (GO:0008202)2.40739693
114regulation of systemic arterial blood pressure (GO:0003073)2.39003044
115* cellular response to inorganic substance (GO:0071241)2.38039184
116reproductive behavior (GO:0019098)2.37215969
117regulation of cholesterol biosynthetic process (GO:0045540)2.36855675
118* cholesterol metabolic process (GO:0008203)2.36779486
119cochlea development (GO:0090102)2.34446404
120regulation of steroid hormone biosynthetic process (GO:0090030)2.34270660
121* alcohol biosynthetic process (GO:0046165)2.28460084
122endothelial cell proliferation (GO:0001935)2.28174699
123* regulation of steroid biosynthetic process (GO:0050810)2.27498182
124* regulation of hormone levels (GO:0010817)2.24613696
125gonadal mesoderm development (GO:0007506)2.23947610
126* response to corticosterone (GO:0051412)2.23514915
127detection of external biotic stimulus (GO:0098581)2.23458324
128phenol-containing compound biosynthetic process (GO:0046189)2.22380547
129steroid catabolic process (GO:0006706)2.22219522
130negative regulation of reproductive process (GO:2000242)2.22070769
131receptor guanylyl cyclase signaling pathway (GO:0007168)2.21668584
132relaxation of smooth muscle (GO:0044557)2.18645257
133* androgen biosynthetic process (GO:0006702)16.0925790
134* estrogen biosynthetic process (GO:0006703)15.5520149
135* glucocorticoid metabolic process (GO:0008211)13.9818395
136* C21-steroid hormone metabolic process (GO:0008207)13.2665942
137cellular response to zinc ion (GO:0071294)10.4898066
138* hormone biosynthetic process (GO:0042446)10.2133555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.89903073
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.99730154
3ESR1_15608294_ChIP-ChIP_MCF-7_Human5.15133250
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse5.01260722
5CLOCK_20551151_ChIP-Seq_293T_Human4.23616510
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.58980505
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.39524048
8SRY_22984422_ChIP-ChIP_TESTIS_Rat3.26442129
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.85317826
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.74929729
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.71473370
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63583184
13GBX2_23144817_ChIP-Seq_PC3_Human2.56220935
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.48896752
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.35068066
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.28826746
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.24186972
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11366388
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05624053
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.96151895
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94798434
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86797924
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86564461
24NFIB_24661679_ChIP-Seq_LUNG_Mouse1.80711915
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79598381
26AR_21572438_ChIP-Seq_LNCaP_Human1.77560629
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.77434973
28NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68992123
29NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68992123
30CDX2_20551321_ChIP-Seq_CACO-2_Human1.68616985
31TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66122802
32POU5F1_16518401_ChIP-PET_MESCs_Mouse1.64454305
33GATA2_19941826_ChIP-Seq_K562_Human1.63642652
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61818015
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61818015
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.61371232
37RXR_22158963_ChIP-Seq_LIVER_Mouse1.61227624
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60001751
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59086373
40EZH2_22144423_ChIP-Seq_EOC_Human1.56328386
41LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54819693
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53239132
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.51178588
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50774295
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50491865
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50464360
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47268237
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.43487949
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42780486
50ELK4_26923725_Chip-Seq_MESODERM_Mouse1.38023349
51* LXR_22292898_ChIP-Seq_THP-1_Human1.34020263
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33128762
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31878443
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31640083
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.30067438
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28967856
57KDM2B_26808549_Chip-Seq_K562_Human1.26566490
58DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24063337
59KDM2B_26808549_Chip-Seq_DND41_Human1.23988377
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22358292
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21325654
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20771668
63LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20432361
64ESET_19884257_ChIP-Seq_ESCs_Mouse1.19811086
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17057582
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16959210
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16959210
68GATA2_21666600_ChIP-Seq_HMVEC_Human1.16051698
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14717257
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14695032
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13312026
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12030627
73LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11706416
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10822279
75YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09973164
76EGR1_19032775_ChIP-ChIP_M12_Human1.09588439
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09079943
78SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07894311
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07789047
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07215835
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07156550
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07119000
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06733342
84TBX20_22080862_ChIP-Seq_HEART_Mouse1.06232971
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.06232971
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05593939
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04744681
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04590889
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03435390
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02486035
91NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01948924
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01140878
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01082809
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.00363742
95GATA1_19941826_ChIP-Seq_K562_Human1.00207630
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99191565
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.98981850
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98875041
99FOXA2_19822575_ChIP-Seq_HepG2_Human0.97873854
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97626266
101RING1B_27294783_Chip-Seq_ESCs_Mouse0.97024545
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96653887
103AR_25329375_ChIP-Seq_VCAP_Human0.96619548
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96175744
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96175744
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96175744
107WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95536206
108SMAD4_21799915_ChIP-Seq_A2780_Human0.94278763
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94272640
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.92301513
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92216999
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91547725
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91010100
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90890197
115ELK3_25401928_ChIP-Seq_HUVEC_Human0.89834456
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89345307
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.88197902
118GF1_26923725_Chip-Seq_HPCs_Mouse0.87823413
119RACK7_27058665_Chip-Seq_MCF-7_Human0.87208483
120STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.86994544
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86948930
122GATA4_25053715_ChIP-Seq_YYC3_Human0.86914107
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86657682
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86278623
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85260677
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84854862
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.84420285
128* SMAD4_21741376_ChIP-Seq_EPCs_Human0.84069915
129GATA6_25053715_ChIP-Seq_YYC3_Human0.83471809
130CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83201454
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83016754
132EED_16625203_ChIP-ChIP_MESCs_Mouse0.82655594
133VDR_22108803_ChIP-Seq_LS180_Human0.82595299
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80140265
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.79502290
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79196186
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78731038
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.78041143
139ISL1_27105846_Chip-Seq_CPCs_Mouse0.77336852
140NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77185270
141TCF4_22108803_ChIP-Seq_LS180_Human0.76659642
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.76051983
143RING1B_27294783_Chip-Seq_NPCs_Mouse0.76009669
144GATA4_21415370_ChIP-Seq_HL-1_Mouse0.76006688
145TBL1_22424771_ChIP-Seq_293T_Human0.75952552
146TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75768295
147EZH2_27304074_Chip-Seq_ESCs_Mouse0.75715478
148JARID2_20064375_ChIP-Seq_MESCs_Mouse0.75622161
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75542179
150TAL1_26923725_Chip-Seq_HPCs_Mouse0.74840629
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73627683
152CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73145196
153ARNT_22903824_ChIP-Seq_MCF-7_Human0.72574373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002909_abnormal_adrenal_gland9.70425930
2* MP0000639_abnormal_adrenal_gland7.77085431
3MP0008004_abnormal_stomach_pH5.48189606
4MP0001765_abnormal_ion_homeostasis4.64771224
5MP0009840_abnormal_foam_cell4.35830243
6MP0002822_catalepsy3.45482794
7MP0003941_abnormal_skin_development3.35289873
8MP0005647_abnormal_sex_gland3.32848959
9MP0003011_delayed_dark_adaptation3.31296400
10MP0000230_abnormal_systemic_arterial3.25782454
11MP0005636_abnormal_mineral_homeostasis3.07116102
12MP0005083_abnormal_biliary_tract2.88778113
13MP0004084_abnormal_cardiac_muscle2.49900989
14MP0008875_abnormal_xenobiotic_pharmacok2.41336218
15MP0003786_premature_aging2.40978782
16MP0000631_abnormal_neuroendocrine_gland2.30822531
17MP0005319_abnormal_enzyme/_coenzyme2.28514571
18MP0003638_abnormal_response/metabolism_2.22328858
19MP0004883_abnormal_blood_vessel2.04369297
20MP0010329_abnormal_lipoprotein_level1.93874977
21MP0003186_abnormal_redox_activity1.87690923
22MP0001756_abnormal_urination1.84112962
23MP0000647_abnormal_sebaceous_gland1.80936141
24MP0005389_reproductive_system_phenotype1.73434541
25MP0003300_gastrointestinal_ulcer1.71863040
26MP0009780_abnormal_chondrocyte_physiolo1.67937612
27MP0004036_abnormal_muscle_relaxation1.65215850
28MP0003329_amyloid_beta_deposits1.64713270
29* MP0003953_abnormal_hormone_level1.64542909
30MP0004085_abnormal_heartbeat1.64242200
31MP0005584_abnormal_enzyme/coenzyme_acti1.63551442
32MP0001984_abnormal_olfaction1.62894011
33MP0000538_abnormal_urinary_bladder1.58177309
34MP0002837_dystrophic_cardiac_calcinosis1.54619910
35MP0003123_paternal_imprinting1.51084012
36MP0002160_abnormal_reproductive_system1.44840209
37MP0005379_endocrine/exocrine_gland_phen1.43643648
38MP0001919_abnormal_reproductive_system1.38420538
39MP0010368_abnormal_lymphatic_system1.36992684
40MP0009053_abnormal_anal_canal1.36761039
41MP0005503_abnormal_tendon_morphology1.34376112
42MP0009643_abnormal_urine_homeostasis1.33382191
43MP0008995_early_reproductive_senescence1.33208499
44MP0003122_maternal_imprinting1.31084828
45MP0006276_abnormal_autonomic_nervous1.28251937
46MP0002254_reproductive_system_inflammat1.27551323
47MP0001661_extended_life_span1.26180244
48MP0005187_abnormal_penis_morphology1.25785942
49MP0010630_abnormal_cardiac_muscle1.21462454
50MP0004019_abnormal_vitamin_homeostasis1.13125434
51MP0006138_congestive_heart_failure1.11762807
52MP0004134_abnormal_chest_morphology1.09595096
53MP0003942_abnormal_urinary_system1.05168335
54MP0005164_abnormal_response_to1.04849166
55MP0000537_abnormal_urethra_morphology1.04142246
56MP0001879_abnormal_lymphatic_vessel1.03922308
57MP0008438_abnormal_cutaneous_collagen1.02938572
58MP0000604_amyloidosis1.02497225
59MP0002938_white_spotting1.02038715
60MP0003283_abnormal_digestive_organ1.00702587
61MP0004145_abnormal_muscle_electrophysio1.00117002
62MP0006035_abnormal_mitochondrial_morpho0.99554867
63MP0000751_myopathy0.95710342
64MP0002118_abnormal_lipid_homeostasis0.93638247
65MP0004272_abnormal_basement_membrane0.92165849
66MP0008961_abnormal_basal_metabolism0.91694446
67MP0002269_muscular_atrophy0.91623819
68MP0005623_abnormal_meninges_morphology0.90453071
69MP0000566_synostosis0.90211906
70MP0001485_abnormal_pinna_reflex0.88869442
71MP0004087_abnormal_muscle_fiber0.86904460
72MP0002557_abnormal_social/conspecific_i0.84917688
73MP0000266_abnormal_heart_morphology0.83505582
74MP0005253_abnormal_eye_physiology0.83161672
75MP0002295_abnormal_pulmonary_circulatio0.81655576
76MP0003315_abnormal_perineum_morphology0.81458637
77MP0005365_abnormal_bile_salt0.81370091
78MP0009250_abnormal_appendicular_skeleto0.81180689
79MP0000343_altered_response_to0.81106898
80MP0003115_abnormal_respiratory_system0.79017436
81MP0002078_abnormal_glucose_homeostasis0.76976895
82MP0002127_abnormal_cardiovascular_syste0.76319671
83* MP0000653_abnormal_sex_gland0.76239145
84MP0000462_abnormal_digestive_system0.75996365
85MP0000003_abnormal_adipose_tissue0.74922695
86MP0004130_abnormal_muscle_cell0.74772459
87MP0002069_abnormal_eating/drinking_beha0.74594719
88MP0003959_abnormal_lean_body0.74064794
89MP0003385_abnormal_body_wall0.73715266
90MP0001440_abnormal_grooming_behavior0.70397114
91MP0003705_abnormal_hypodermis_morpholog0.70146082
92* MP0001119_abnormal_female_reproductive0.67376901
93MP0002896_abnormal_bone_mineralization0.67188752
94MP0005452_abnormal_adipose_tissue0.66787364
95MP0003567_abnormal_fetal_cardiomyocyte0.65974774
96MP0005595_abnormal_vascular_smooth0.65928138
97MP0003566_abnormal_cell_adhesion0.64821261
98* MP0001145_abnormal_male_reproductive0.64764098
99MP0004233_abnormal_muscle_weight0.64436375
100MP0003191_abnormal_cellular_cholesterol0.63823220
101MP0003699_abnormal_female_reproductive0.63735326
102* MP0009642_abnormal_blood_homeostasis0.63231440
103MP0003279_aneurysm0.60880505
104MP0004858_abnormal_nervous_system0.60379033
105MP0001915_intracranial_hemorrhage0.59693189
106MP0008872_abnormal_physiological_respon0.59245771
107MP0001177_atelectasis0.59104161
108MP0000609_abnormal_liver_physiology0.58717460
109MP0002998_abnormal_bone_remodeling0.58043185
110MP0003091_abnormal_cell_migration0.58021596
111MP0008007_abnormal_cellular_replicative0.57727395
112MP0005385_cardiovascular_system_phenoty0.57584721
113MP0001544_abnormal_cardiovascular_syste0.57584721
114MP0003690_abnormal_glial_cell0.57522300
115MP0008469_abnormal_protein_level0.56614768
116MP0001529_abnormal_vocalization0.56474043
117MP0009278_abnormal_bone_marrow0.55512074
118* MP0001929_abnormal_gametogenesis0.55077770
119MP0000013_abnormal_adipose_tissue0.53879870
120MP0005670_abnormal_white_adipose0.53731381
121MP0002135_abnormal_kidney_morphology0.53572177
122* MP0002210_abnormal_sex_determination0.53545945
123MP0002136_abnormal_kidney_physiology0.53199165
124MP0005535_abnormal_body_temperature0.53197070
125MP0003121_genomic_imprinting0.52868262
126MP0005375_adipose_tissue_phenotype0.52471467
127MP0003950_abnormal_plasma_membrane0.50150058
128MP0000750_abnormal_muscle_regeneration0.50132210
129MP0008770_decreased_survivor_rate0.50065257
130MP0009672_abnormal_birth_weight0.49308563
131MP0003195_calcinosis0.48525989
132MP0005448_abnormal_energy_balance0.48514848
133MP0005508_abnormal_skeleton_morphology0.47534639
134MP0000465_gastrointestinal_hemorrhage0.47155921
135MP0008775_abnormal_heart_ventricle0.46484905
136MP0005410_abnormal_fertilization0.46380358
137MP0004043_abnormal_pH_regulation0.45587189
138MP0005334_abnormal_fat_pad0.45433471
139MP0005167_abnormal_blood-brain_barrier0.43476156
140MP0003943_abnormal_hepatobiliary_system0.42680351
141MP0005076_abnormal_cell_differentiation0.40806638
142MP0005391_vision/eye_phenotype0.40610405
143MP0001324_abnormal_eye_pigmentation0.37983117
144MP0008057_abnormal_DNA_replication0.37824019
145MP0000598_abnormal_liver_morphology0.36991571
146MP0005332_abnormal_amino_acid0.36346825
147MP0003698_abnormal_male_reproductive0.35981423
148MP0005330_cardiomyopathy0.35710487
149MP0002115_abnormal_skeleton_extremities0.35486872
150MP0004484_altered_response_of0.34928984
151MP0005275_abnormal_skin_tensile0.32852774
152MP0003632_abnormal_nervous_system0.32183654
153MP0004782_abnormal_surfactant_physiolog0.31770012

Predicted human phenotypes

RankGene SetZ-score
1Hyperaldosteronism (HP:0000859)9.73716151
2* Renal salt wasting (HP:0000127)9.22690543
3Abnormality of renin-angiotensin system (HP:0000847)9.16579043
4Increased circulating renin level (HP:0000848)8.99115754
5Abnormal sex determination (HP:0012244)8.09355538
6Sex reversal (HP:0012245)8.09355538
7Hypoplasia of the uterus (HP:0000013)7.66935224
8Orthostatic hypotension (HP:0001278)7.07481863
9Neonatal onset (HP:0003623)6.68918719
10Aplasia/hypoplasia of the uterus (HP:0008684)6.20549006
11Adrenal overactivity (HP:0002717)5.27738728
12Hyperkalemia (HP:0002153)5.17185622
13Large earlobe (HP:0009748)4.88780108
14Testicular neoplasm (HP:0010788)4.78970265
15Accelerated skeletal maturation (HP:0005616)4.69741301
16Abnormality of potassium homeostasis (HP:0011042)4.66685416
17Anomalous pulmonary venous return (HP:0010772)4.63739200
18Azoospermia (HP:0000027)4.31115619
19Gonadotropin excess (HP:0000837)4.24361974
20Episodic fever (HP:0001954)4.17859242
21Abnormality of the pulmonary veins (HP:0011718)3.98839283
22Gonadal dysgenesis (HP:0000133)3.97740728
23Hypokalemia (HP:0002900)3.72730721
24Clitoromegaly (HP:0000057)3.59474153
25Gynecomastia (HP:0000771)3.54235490
26Bifid scrotum (HP:0000048)3.53258569
27Complement deficiency (HP:0004431)3.47577057
28Hyponatremia (HP:0002902)3.46108651
29Relative macrocephaly (HP:0004482)3.41465665
30Partial agenesis of the corpus callosum (HP:0001338)3.40593228
31Abnormal autonomic nervous system physiology (HP:0012332)3.19659287
32Hyperpituitarism (HP:0010514)3.14580769
33Abnormal spermatogenesis (HP:0008669)3.07191153
34Cupped ear (HP:0000378)3.04765083
35Neonatal hypoglycemia (HP:0001998)3.03571884
36Male pseudohermaphroditism (HP:0000037)3.03064109
37Abnormality of sodium homeostasis (HP:0010931)2.99343137
38Precocious puberty (HP:0000826)2.96224424
39Premature ovarian failure (HP:0008209)2.96089524
40Primary adrenal insufficiency (HP:0008207)2.87947066
41Primary amenorrhea (HP:0000786)2.78688511
42Epidermoid cyst (HP:0200040)2.70914222
43Recurrent gram-negative bacterial infections (HP:0005420)2.69055795
44Hypotension (HP:0002615)2.68095724
45Cerebral palsy (HP:0100021)2.64041124
46Alkalosis (HP:0001948)2.60933189
47Myelomeningocele (HP:0002475)2.56312637
48Abnormality of complement system (HP:0005339)2.51178743
49Choanal stenosis (HP:0000452)2.48172112
50Multifactorial inheritance (HP:0001426)2.47269714
51Ureteral duplication (HP:0000073)2.45792998
52Lymphangioma (HP:0100764)2.36551063
53Abnormality of the clitoris (HP:0000056)2.34489860
54Tracheal stenosis (HP:0002777)2.34319606
55Secondary amenorrhea (HP:0000869)2.32774383
56Mesangial abnormality (HP:0001966)2.28598208
57Bilateral microphthalmos (HP:0007633)2.27554167
58Absent eyebrow (HP:0002223)2.21647443
59Abnormal pancreas size (HP:0012094)2.21370258
60Morphological abnormality of the middle ear (HP:0008609)2.21153253
61Macroorchidism (HP:0000053)2.08665899
62Xanthomatosis (HP:0000991)2.08234170
63* Hypospadias (HP:0000047)2.06454262
64Vertebral clefting (HP:0008428)2.04253132
65Mitral stenosis (HP:0001718)2.02730254
66Abnormality of the aortic arch (HP:0012303)2.00486049
67Enlarged penis (HP:0000040)11.9244600
68Decreased circulating renin level (HP:0003351)10.6522589
69Rhizomelia (HP:0008905)1.99305027
70Ulnar bowing (HP:0003031)1.99189113
71Skin nodule (HP:0200036)1.98599319
72Diastasis recti (HP:0001540)1.98266805
73Short humerus (HP:0005792)1.92754641
74Neurofibrillary tangles (HP:0002185)1.92338033
75Ventricular fibrillation (HP:0001663)1.90600509
76Septate vagina (HP:0001153)1.90264040
77Broad alveolar ridges (HP:0000187)1.89039742
78Abnormality of carpal bone ossification (HP:0006257)1.87056597
79Shawl scrotum (HP:0000049)1.86985347
80Growth hormone excess (HP:0000845)1.84748669
81Metaphyseal dysplasia (HP:0100255)1.83853775
82Mucopolysacchariduria (HP:0008155)1.83296444
83Urinary glycosaminoglycan excretion (HP:0003541)1.83296444
84Abnormality of secondary sexual hair (HP:0009888)1.82519685
85Abnormality of the axillary hair (HP:0100134)1.82519685
86Pulmonary fibrosis (HP:0002206)1.82163871
87Hydroxyprolinuria (HP:0003080)1.81661200
88Abnormality of proline metabolism (HP:0010907)1.81661200
89Abnormal hemoglobin (HP:0011902)1.80489996
90Patent foramen ovale (HP:0001655)1.79265781
91Hypothermia (HP:0002045)1.77222174
92Acne (HP:0001061)1.75578418
93Cutaneous finger syndactyly (HP:0010554)1.74453446
94Aplasia/hypoplasia of the humerus (HP:0006507)1.73915704
95Short clavicles (HP:0000894)1.72208461
96Breech presentation (HP:0001623)1.70563837
97Facial hemangioma (HP:0000329)1.70272568
98Midline defect of the nose (HP:0004122)1.65480832
99Sparse lateral eyebrow (HP:0005338)1.62778987
100Abnormality of the pubic bones (HP:0003172)1.62342431
101Abnormality of polysaccharide metabolism (HP:0011012)1.61222301
102Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61222301
103Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61222301
104Decreased testicular size (HP:0008734)1.60413449
105Absent hand (HP:0004050)1.59783166
106Scrotal hypoplasia (HP:0000046)1.59589989
107Double outlet right ventricle (HP:0001719)1.58642486
108Congenital malformation of the right heart (HP:0011723)1.58642486
109Aplasia/Hypoplasia of the sternum (HP:0006714)1.57808093
110Bronchomalacia (HP:0002780)1.57643414
111Congenital sensorineural hearing impairment (HP:0008527)1.57147703
112Abnormal lung lobation (HP:0002101)1.55544409
113Absent eyelashes (HP:0000561)1.55143096
114Limited hip movement (HP:0008800)1.54885517
115Aplasia/Hypoplasia of the clavicles (HP:0006710)1.54737346
116Broad metatarsal (HP:0001783)1.53689019
117Cutaneous syndactyly (HP:0012725)1.51991105
118Ectopic anus (HP:0004397)1.51962791
119Coronal craniosynostosis (HP:0004440)1.51128982
120Syncope (HP:0001279)1.51025674
121Ovarian neoplasm (HP:0100615)1.46980278
122Microglossia (HP:0000171)1.42648486
123Aplasia of the musculature (HP:0100854)1.42590487
124Increased number of teeth (HP:0011069)1.40061455
125Rectal prolapse (HP:0002035)1.40010843
126Overlapping toe (HP:0001845)1.39502886
127Atrioventricular block (HP:0001678)1.39135559
128Buphthalmos (HP:0000557)1.37497704
129Generalized hypotonia (HP:0001290)1.33822805
130Arachnodactyly (HP:0001166)1.28719038
131Female pseudohermaphroditism (HP:0010458)1.28314375
132Breast hypoplasia (HP:0003187)1.24650286
133Ureteral stenosis (HP:0000071)1.23417320
134Increased nuchal translucency (HP:0010880)1.22814163
135Protrusio acetabuli (HP:0003179)1.20087441
136Bifid tongue (HP:0010297)1.18726571
137Menstrual irregularities (HP:0000858)1.17510768
138Ankle contracture (HP:0006466)1.15401638
139Dehydration (HP:0001944)1.14505601
140Visceral angiomatosis (HP:0100761)1.13708418
141Hypoplastic nipples (HP:0002557)1.13116223
142Prolonged QT interval (HP:0001657)1.12914125
143Abnormal drinking behavior (HP:0030082)1.09994452
144Polydipsia (HP:0001959)1.09994452
145Ureteral obstruction (HP:0006000)1.08198563
146Split hand (HP:0001171)1.07565588
147Hyperacusis (HP:0010780)1.06112954
148Hyperglycinuria (HP:0003108)1.05883837
149Advanced eruption of teeth (HP:0006288)1.05435999
150Spinal rigidity (HP:0003306)1.04508272
151Heterotopia (HP:0002282)1.04090176
152Hypercalciuria (HP:0002150)1.03704202
153Gastrointestinal dysmotility (HP:0002579)1.03642053
154Abnormality of the alveolar ridges (HP:0006477)1.02942246
155Cerebral aneurysm (HP:0004944)1.02905934
156Abnormality of glutamine family amino acid metabolism (HP:0010902)1.02432512
157Hemangiomatosis (HP:0007461)1.00571811
158Bicornuate uterus (HP:0000813)1.00376298
159Complete atrioventricular canal defect (HP:0001674)0.98350188
160Hepatoblastoma (HP:0002884)0.95934362
161Neoplasm of the adrenal gland (HP:0100631)0.95227292
162Hypokalemic alkalosis (HP:0001949)0.94872494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT39.79806022
2TRIB35.25942983
3ERN14.53009726
4PRPF4B3.76845704
5DDR22.80626670
6CDK72.80033551
7JAK12.74709689
8TAOK32.71515219
9MELK2.55476635
10CAMK1G2.33986453
11MAP3K52.32556560
12TAOK22.11779092
13PKN22.10942636
14SIK11.98372538
15EPHB21.83191442
16FGFR21.71008783
17AKT21.67188773
18CAMK1D1.66268956
19WNK41.64851155
20PINK11.60967354
21FGFR41.56000761
22FER1.55717130
23PNCK1.53479780
24PTK61.49540212
25STK391.43741851
26BCKDK1.41974652
27TGFBR21.37251386
28JAK21.36494476
29PDK31.29906152
30PDK41.29906152
31ICK1.24776879
32TIE11.21922523
33TESK11.17172486
34PIM11.14428387
35STK101.08473729
36FGFR11.05280361
37LRRK21.04495055
38EPHA41.03596177
39PRKD31.02337961
40RIPK11.01462813
41PDGFRA0.98529640
42GRK50.96824496
43PDK20.96680274
44KDR0.94456498
45NLK0.94203879
46MET0.91630730
47PRKAA20.90394534
48PAK40.90383146
49SGK10.90041668
50CAMK40.87960620
51MAP2K20.87149591
52SCYL20.79621744
53NTRK10.78708153
54PTK20.78120213
55NEK90.77069575
56YES10.73623185
57SIK20.73135483
58WNK10.72177656
59CSNK1A1L0.72026599
60MTOR0.70454844
61KSR20.70388244
62UHMK10.68365071
63ILK0.67820254
64PRKD10.67059252
65WNK30.67008684
66INSRR0.66500152
67MAP3K20.66197541
68PTK2B0.65482660
69RIPK40.65167858
70MAPK120.64065459
71CDK120.62805910
72PRKCZ0.61019381
73NTRK30.58096436
74PAK30.55428398
75DYRK20.55210416
76CAMKK10.53829289
77RPS6KA50.53322421
78CDC42BPA0.53035154
79CAMKK20.52336044
80RET0.50083125
81PRKCH0.49667068
82DMPK0.48838555
83BRD40.48362645
84GSK3A0.48130174
85EPHB10.47270939
86MAP3K70.47159579
87LATS20.46518964
88MAPK10.45766609
89TTN0.45294337
90MYLK0.44902529
91* MAPK30.44714059
92KSR10.44426424
93ERBB40.44329580
94SGK30.43446350
95PRKACG0.42861514
96MAP3K40.42713336
97ROCK10.41895569
98PDPK10.41843406
99ROCK20.41702571
100LIMK10.41558153
101MAP3K60.41111573
102RPS6KA30.40803071
103PRKACB0.40614800
104TTK0.39126267
105TNK20.38075745
106CSNK1G10.37955321
107IGF1R0.37307333
108SIK30.36434031
109PRKACA0.36279872
110SRC0.35950299
111MAP2K10.35896086
112MAP2K40.35576402
113ALK0.35360380
114RAF10.33911769
115FLT30.33845613
116CSNK1G20.33588793
117OXSR10.32664174
118MAP3K80.32368392
119NEK10.32307616
120MAPK90.32262066
121SGK20.31862145
122EPHA30.30872824
123MARK20.30319440
124ADRBK10.30285739
125LATS10.30112064
126MAP3K120.29526345
127CDK60.29189844
128CSNK1A10.29032153
129MAP3K10.28596553
130MAPK140.27951587
131SRPK10.27828313
132MST1R0.27004478
133TGFBR10.26044918
134MAP4K20.25253149
135DYRK1A0.25175460
136PDK10.25079187
137PRKCG0.25013113
138MAPKAPK50.24865675
139EEF2K0.24862597
140GRK60.23659766
141CSNK1E0.23411131
142CAMK10.23357863
143PAK20.23333812
144TNIK0.22882368
145ERBB20.22629754
146MAPK80.22616562
147GSK3B0.21218506
148SGK4940.21192887
149SGK2230.21192887
150MAPK150.21148520
151AKT10.21076789
152MAPK100.20954167
153PDGFRB0.20607662
154MAPK70.20574694
155CLK10.20003367

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001409.35383208
2* Aldosterone synthesis and secretion_Homo sapiens_hsa049256.03545463
3* Ovarian steroidogenesis_Homo sapiens_hsa049135.09615277
4Vitamin B6 metabolism_Homo sapiens_hsa007504.09519703
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.05244053
6Fatty acid metabolism_Homo sapiens_hsa012122.98430547
7Tyrosine metabolism_Homo sapiens_hsa003502.82410723
8Fatty acid biosynthesis_Homo sapiens_hsa000612.69103842
9Fatty acid degradation_Homo sapiens_hsa000712.17751374
10Vitamin digestion and absorption_Homo sapiens_hsa049772.07614225
11Steroid biosynthesis_Homo sapiens_hsa001001.86136458
12Fat digestion and absorption_Homo sapiens_hsa049751.79747898
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74585772
14PPAR signaling pathway_Homo sapiens_hsa033201.73220345
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57435896
16Selenocompound metabolism_Homo sapiens_hsa004501.49495605
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48684070
18Propanoate metabolism_Homo sapiens_hsa006401.45219644
19Pyruvate metabolism_Homo sapiens_hsa006201.38856710
20Bile secretion_Homo sapiens_hsa049761.38030041
21Prion diseases_Homo sapiens_hsa050201.37905650
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.36949369
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35736526
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33701347
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30049318
26Renin secretion_Homo sapiens_hsa049241.14958076
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07120066
28Carbon metabolism_Homo sapiens_hsa012000.91126766
29Histidine metabolism_Homo sapiens_hsa003400.90456579
30Fatty acid elongation_Homo sapiens_hsa000620.89798779
31Lysine degradation_Homo sapiens_hsa003100.89397152
32Glycosaminoglycan degradation_Homo sapiens_hsa005310.88351614
33cAMP signaling pathway_Homo sapiens_hsa040240.78244675
34ABC transporters_Homo sapiens_hsa020100.70746568
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68535601
36Nitrogen metabolism_Homo sapiens_hsa009100.67306624
37Glutathione metabolism_Homo sapiens_hsa004800.63670776
38Prostate cancer_Homo sapiens_hsa052150.63206985
39Glycerolipid metabolism_Homo sapiens_hsa005610.62590982
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60273344
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57406721
42Butanoate metabolism_Homo sapiens_hsa006500.56686369
43Adipocytokine signaling pathway_Homo sapiens_hsa049200.54789436
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.54756500
45Tryptophan metabolism_Homo sapiens_hsa003800.53656961
46Circadian entrainment_Homo sapiens_hsa047130.53179822
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51203895
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49536798
49beta-Alanine metabolism_Homo sapiens_hsa004100.45968424
50Insulin resistance_Homo sapiens_hsa049310.44727215
51Estrogen signaling pathway_Homo sapiens_hsa049150.42589680
52GnRH signaling pathway_Homo sapiens_hsa049120.41597618
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41402288
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39278353
55Peroxisome_Homo sapiens_hsa041460.38564348
56Dopaminergic synapse_Homo sapiens_hsa047280.38410509
57Renin-angiotensin system_Homo sapiens_hsa046140.36904062
58Focal adhesion_Homo sapiens_hsa045100.36110360
59Glucagon signaling pathway_Homo sapiens_hsa049220.35650776
60Retinol metabolism_Homo sapiens_hsa008300.33730540
61Cocaine addiction_Homo sapiens_hsa050300.33179650
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32840448
63Oxytocin signaling pathway_Homo sapiens_hsa049210.32535834
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32317725
65Amphetamine addiction_Homo sapiens_hsa050310.32111770
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31541668
67Hedgehog signaling pathway_Homo sapiens_hsa043400.31199978
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30603949
69ECM-receptor interaction_Homo sapiens_hsa045120.30367204
70Insulin secretion_Homo sapiens_hsa049110.28190744
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25214266
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24563182
73Sphingolipid metabolism_Homo sapiens_hsa006000.24515773
74Proteoglycans in cancer_Homo sapiens_hsa052050.23747165
75Morphine addiction_Homo sapiens_hsa050320.23484486
76AMPK signaling pathway_Homo sapiens_hsa041520.23346462
77Renal cell carcinoma_Homo sapiens_hsa052110.22869303
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.22430520
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.22383041
80Choline metabolism in cancer_Homo sapiens_hsa052310.22032230
81Linoleic acid metabolism_Homo sapiens_hsa005910.21937861
82Wnt signaling pathway_Homo sapiens_hsa043100.21729229
83Thyroid hormone synthesis_Homo sapiens_hsa049180.21567023
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20643026
85Salivary secretion_Homo sapiens_hsa049700.19300706
86Sulfur metabolism_Homo sapiens_hsa009200.18361943
87Prolactin signaling pathway_Homo sapiens_hsa049170.18292776
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17974053
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17579669
90Phagosome_Homo sapiens_hsa041450.17560290
91Calcium signaling pathway_Homo sapiens_hsa040200.17191653
92Gastric acid secretion_Homo sapiens_hsa049710.17172998
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17138963
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.16962107
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16824077
96Biosynthesis of amino acids_Homo sapiens_hsa012300.16492397
97Vibrio cholerae infection_Homo sapiens_hsa051100.16342819
98Pentose phosphate pathway_Homo sapiens_hsa000300.16280740
99Long-term depression_Homo sapiens_hsa047300.15744004
100Systemic lupus erythematosus_Homo sapiens_hsa053220.15661353
101Chemical carcinogenesis_Homo sapiens_hsa052040.15530404
102VEGF signaling pathway_Homo sapiens_hsa043700.15444576
103Dilated cardiomyopathy_Homo sapiens_hsa054140.15323292
104Hepatitis C_Homo sapiens_hsa051600.14590465
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13984826
106Long-term potentiation_Homo sapiens_hsa047200.13876263
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13646940
108Circadian rhythm_Homo sapiens_hsa047100.13409870
109Metabolic pathways_Homo sapiens_hsa011000.13177935
110Dorso-ventral axis formation_Homo sapiens_hsa043200.12836036
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.12731959
112Lysosome_Homo sapiens_hsa041420.12530305
113Rap1 signaling pathway_Homo sapiens_hsa040150.12414277
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12245625
115Basal cell carcinoma_Homo sapiens_hsa052170.11957202
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11626236
117Insulin signaling pathway_Homo sapiens_hsa049100.10767730
118Complement and coagulation cascades_Homo sapiens_hsa046100.10433652
119mTOR signaling pathway_Homo sapiens_hsa041500.09781828
120Melanogenesis_Homo sapiens_hsa049160.09491306
121Protein digestion and absorption_Homo sapiens_hsa049740.09417177
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.09123241
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08745907
124Gap junction_Homo sapiens_hsa045400.07653505
125TGF-beta signaling pathway_Homo sapiens_hsa043500.07432074
126Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06975968
127Axon guidance_Homo sapiens_hsa043600.06824446
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.05463817
129Pertussis_Homo sapiens_hsa051330.04614161
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.02659225
131Small cell lung cancer_Homo sapiens_hsa052220.02264582
132Staphylococcus aureus infection_Homo sapiens_hsa051500.02055283
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.01853642
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01451113
135FoxO signaling pathway_Homo sapiens_hsa040680.00563128
136Galactose metabolism_Homo sapiens_hsa000520.00472129
137Ras signaling pathway_Homo sapiens_hsa04014-0.0091827
138Mineral absorption_Homo sapiens_hsa04978-0.0037963
139Amoebiasis_Homo sapiens_hsa05146-0.0017729

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