STARD13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.20444046
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.20444046
3L-phenylalanine metabolic process (GO:0006558)3.97267378
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.97267378
5lymphangiogenesis (GO:0001946)3.65222406
6chondrocyte proliferation (GO:0035988)3.47875715
7cell migration involved in heart development (GO:0060973)3.40411225
8regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.37400876
9negative regulation of fibrinolysis (GO:0051918)3.28290279
10aromatic amino acid family catabolic process (GO:0009074)3.22356641
11negative regulation of fatty acid transport (GO:2000192)3.22230379
12skin morphogenesis (GO:0043589)3.21478123
13coronary vasculature morphogenesis (GO:0060977)3.05863730
14basement membrane organization (GO:0071711)3.04188514
15regulation of fibrinolysis (GO:0051917)3.01788954
16protein carboxylation (GO:0018214)3.01427674
17peptidyl-glutamic acid carboxylation (GO:0017187)3.01427674
18regulation of integrin-mediated signaling pathway (GO:2001044)3.00914994
19wound healing, spreading of epidermal cells (GO:0035313)2.95032575
20alpha-linolenic acid metabolic process (GO:0036109)2.94670087
21intestinal cholesterol absorption (GO:0030299)2.92577213
22cell-substrate junction assembly (GO:0007044)2.92054292
23sequestering of extracellular ligand from receptor (GO:0035581)2.89759351
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87558339
25endothelial cell chemotaxis (GO:0035767)2.84324035
26regulation of protein activation cascade (GO:2000257)2.83239542
27endodermal cell differentiation (GO:0035987)2.82649744
28positive regulation of fatty acid beta-oxidation (GO:0032000)2.82395481
29transcytosis (GO:0045056)2.79620210
30bile acid biosynthetic process (GO:0006699)2.78909055
31negative regulation of protein localization to cell surface (GO:2000009)2.78520353
32protein heterotrimerization (GO:0070208)2.78205401
33drug transmembrane transport (GO:0006855)2.77851386
34regulation of cholesterol homeostasis (GO:2000188)2.77711380
35extracellular matrix assembly (GO:0085029)2.77669073
36hemidesmosome assembly (GO:0031581)2.76274046
37regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.75946554
38complement activation, alternative pathway (GO:0006957)2.75429557
39tyrosine metabolic process (GO:0006570)2.74399389
40COPII vesicle coating (GO:0048208)2.73828322
41regulation of complement activation (GO:0030449)2.72704795
42substrate adhesion-dependent cell spreading (GO:0034446)2.72183287
43peptidyl-tyrosine autophosphorylation (GO:0038083)2.71575930
44blood vessel maturation (GO:0001955)2.71356610
45sprouting angiogenesis (GO:0002040)2.69901952
46regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.69365669
47cardiac myofibril assembly (GO:0055003)2.67965554
48cell migration involved in sprouting angiogenesis (GO:0002042)2.67172711
49retina vasculature morphogenesis in camera-type eye (GO:0061299)2.66591683
50glomerular basement membrane development (GO:0032836)2.66018634
51endocrine hormone secretion (GO:0060986)2.65187031
52short-chain fatty acid metabolic process (GO:0046459)2.64650521
53peripheral nervous system axon ensheathment (GO:0032292)2.63233615
54myelination in peripheral nervous system (GO:0022011)2.63233615
55regulation of extracellular matrix disassembly (GO:0010715)2.61171533
56regulation of pigment cell differentiation (GO:0050932)2.61099787
57cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.61099272
58substrate-dependent cell migration (GO:0006929)2.60583986
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.58636361
60response to gravity (GO:0009629)2.57715083
61cysteine metabolic process (GO:0006534)2.55544554
62peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.54814795
63smooth muscle tissue development (GO:0048745)2.54548301
64triglyceride homeostasis (GO:0070328)2.54252562
65acylglycerol homeostasis (GO:0055090)2.54252562
66positive regulation of fibroblast migration (GO:0010763)2.53675968
67positive regulation of fatty acid oxidation (GO:0046321)2.51561618
68homocysteine metabolic process (GO:0050667)2.51358581
69kidney mesenchyme development (GO:0072074)2.50658066
70cell-substrate adherens junction assembly (GO:0007045)2.50479929
71focal adhesion assembly (GO:0048041)2.50479929
72maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.49804446
73membrane raft organization (GO:0031579)2.49493863
74regulation of axon extension involved in axon guidance (GO:0048841)2.48918642
75atrioventricular valve morphogenesis (GO:0003181)2.48508783
76coenzyme catabolic process (GO:0009109)2.48401489
77regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.48096163
78fatty acid beta-oxidation (GO:0006635)2.47701068
79plasma membrane repair (GO:0001778)2.47432878
80positive regulation of endothelial cell apoptotic process (GO:2000353)2.46925885
81venous blood vessel morphogenesis (GO:0048845)2.46472936
82negative regulation of protein activation cascade (GO:2000258)2.46277736
83glyoxylate metabolic process (GO:0046487)2.45784096
84hippo signaling (GO:0035329)2.45705486
85sulfur amino acid catabolic process (GO:0000098)2.45385180
86bile acid metabolic process (GO:0008206)2.44942664
87adherens junction assembly (GO:0034333)2.44883216
88exocrine pancreas development (GO:0031017)2.44240278
89fibrinolysis (GO:0042730)2.43736436
90vascular endothelial growth factor signaling pathway (GO:0038084)2.42469711
91ovulation from ovarian follicle (GO:0001542)2.41138927
92regulation of transforming growth factor beta2 production (GO:0032909)2.39406067
93platelet-derived growth factor receptor signaling pathway (GO:0048008)2.38666301
94barbed-end actin filament capping (GO:0051016)2.38654805
95positive regulation of muscle hypertrophy (GO:0014742)2.37769808
96positive regulation of cardiac muscle hypertrophy (GO:0010613)2.37769808
97phospholipid homeostasis (GO:0055091)2.37333907
98macroautophagy (GO:0016236)2.37172037
99extracellular fibril organization (GO:0043206)2.36787878
100aromatic amino acid family metabolic process (GO:0009072)2.36528144
101negative regulation of digestive system process (GO:0060457)2.35992465
102protein retention in ER lumen (GO:0006621)2.35915516
103plasma lipoprotein particle clearance (GO:0034381)2.35593065
104fatty acid transmembrane transport (GO:1902001)2.33910942
105fatty-acyl-CoA biosynthetic process (GO:0046949)2.33814024
106endocardial cushion morphogenesis (GO:0003203)2.33480448
107metanephric mesenchyme development (GO:0072075)2.33092733
108lysine metabolic process (GO:0006553)2.33049788
109lysine catabolic process (GO:0006554)2.33049788
110fatty acid catabolic process (GO:0009062)2.33045932
111vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.32827796
112tryptophan metabolic process (GO:0006568)2.32278487
113indole-containing compound catabolic process (GO:0042436)2.31254889
114indolalkylamine catabolic process (GO:0046218)2.31254889
115tryptophan catabolic process (GO:0006569)2.31254889
116type B pancreatic cell development (GO:0003323)2.30913796
117protein localization to cell surface (GO:0034394)2.30800490
118fatty acid oxidation (GO:0019395)2.30596341
119high-density lipoprotein particle remodeling (GO:0034375)2.29881703
120endothelial cell morphogenesis (GO:0001886)2.29347492
121regulation of muscle hypertrophy (GO:0014743)2.29306596
122low-density lipoprotein particle clearance (GO:0034383)2.29275454
123collagen fibril organization (GO:0030199)2.29004773
124negative regulation of anoikis (GO:2000811)2.28717192
125desmosome organization (GO:0002934)2.28629730
126heart trabecula formation (GO:0060347)2.28421282
127muscle cell cellular homeostasis (GO:0046716)2.28151702
128acetyl-CoA metabolic process (GO:0006084)2.27772227
129apoptotic cell clearance (GO:0043277)2.27584761
130negative regulation of axon extension involved in axon guidance (GO:0048843)2.26414115
131lipid oxidation (GO:0034440)2.25895546
132type B pancreatic cell proliferation (GO:0044342)2.25837746
133positive regulation of p38MAPK cascade (GO:1900745)2.25822599
134mesenchymal-epithelial cell signaling (GO:0060638)2.25820684
135kynurenine metabolic process (GO:0070189)2.25412695
136regulation of bile acid biosynthetic process (GO:0070857)2.24816706
137negative regulation of wound healing (GO:0061045)2.24314005
138myofibril assembly (GO:0030239)2.24120124
139fibroblast migration (GO:0010761)2.24005707
140regulation of triglyceride catabolic process (GO:0010896)2.23823729
141keratan sulfate catabolic process (GO:0042340)2.23820029
142negative regulation of nitric-oxide synthase activity (GO:0051001)2.23762176
143wound healing, spreading of cells (GO:0044319)2.23505578
144regulation of p38MAPK cascade (GO:1900744)2.23134176
145protein localization to endosome (GO:0036010)2.22894643
146glomerular filtration (GO:0003094)2.22881501
147endothelium development (GO:0003158)2.22694885
148urea metabolic process (GO:0019627)2.22562773
149urea cycle (GO:0000050)2.22562773
150stress fiber assembly (GO:0043149)2.22400079
151collagen metabolic process (GO:0032963)2.22286971
152endocardial cushion development (GO:0003197)2.21796099
153negative regulation of lipase activity (GO:0060192)2.21281222
154regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.21083652
155reverse cholesterol transport (GO:0043691)2.20790251
156extracellular matrix organization (GO:0030198)2.20413354
157cell adhesion mediated by integrin (GO:0033627)2.20130801
158very long-chain fatty acid metabolic process (GO:0000038)2.19864242
159long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.19631638
160negative regulation of complement activation (GO:0045916)2.19579839
161extracellular structure organization (GO:0043062)2.19478088
162positive regulation of endothelial cell migration (GO:0010595)2.19432903
163regulation of the force of heart contraction (GO:0002026)2.19265257
164actin filament depolymerization (GO:0030042)2.19224605
165regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.19086578
166epoxygenase P450 pathway (GO:0019373)2.19033038
167cellular ketone body metabolic process (GO:0046950)2.18562819
168positive regulation of lipid catabolic process (GO:0050996)2.18488489
169bile acid and bile salt transport (GO:0015721)2.18455499
170amino-acid betaine metabolic process (GO:0006577)2.18432941
171growth hormone receptor signaling pathway (GO:0060396)2.18346495
172positive regulation of glycogen biosynthetic process (GO:0045725)2.17885785
173lung lobe morphogenesis (GO:0060463)2.17745582
174negative regulation of blood coagulation (GO:0030195)2.17031662
175negative regulation of hemostasis (GO:1900047)2.17031662
176actin-mediated cell contraction (GO:0070252)2.16939693
177regulation of plasminogen activation (GO:0010755)2.16234482
178extracellular matrix disassembly (GO:0022617)2.16137804
179monocarboxylic acid catabolic process (GO:0072329)2.16032852
180positive regulation of blood vessel endothelial cell migration (GO:0043536)2.15762336
181aspartate family amino acid catabolic process (GO:0009068)2.15529188
182positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.15302618
183negative regulation of Rho protein signal transduction (GO:0035024)2.14924053
184cell-substrate adhesion (GO:0031589)2.14794171
185pericardium development (GO:0060039)2.14697153
186fatty acid elongation (GO:0030497)2.14477936
187cell-matrix adhesion (GO:0007160)2.13931264
188regulation of fatty acid beta-oxidation (GO:0031998)2.13555984
189regulation of endothelial cell apoptotic process (GO:2000351)2.13282021
190renal filtration (GO:0097205)2.13229307
191thioester biosynthetic process (GO:0035384)2.12891472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.99742701
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.97088682
3RXR_22158963_ChIP-Seq_LIVER_Mouse2.92195711
4* LXR_22158963_ChIP-Seq_LIVER_Mouse2.79774783
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.44477405
6PPARA_22158963_ChIP-Seq_LIVER_Mouse2.29157228
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23092951
8* EP300_21415370_ChIP-Seq_HL-1_Mouse2.21938997
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.15064191
10* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.07689520
11* BRD4_25478319_ChIP-Seq_HGPS_Human2.02161007
12CLOCK_20551151_ChIP-Seq_293T_Human1.95335292
13* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.88556256
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87018585
15FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86483309
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82460974
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.79933735
18STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79169503
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76945547
20GBX2_23144817_ChIP-Seq_PC3_Human1.76449221
21* PIAS1_25552417_ChIP-Seq_VCAP_Human1.67255999
22* ESR1_20079471_ChIP-ChIP_T-47D_Human1.64845329
23* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.59666372
24* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.59666372
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.58562145
26CJUN_26792858_Chip-Seq_BT549_Human1.55682359
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53324909
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51083256
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48302624
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.46197787
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45179468
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.44853628
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.44004930
34* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43479171
35* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43428064
36* FOXA2_19822575_ChIP-Seq_HepG2_Human1.42408057
37BCAT_22108803_ChIP-Seq_LS180_Human1.36362646
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36207294
39* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35711584
40* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35711584
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34231989
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34148483
43* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33260600
44* GATA2_21666600_ChIP-Seq_HMVEC_Human1.27428202
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.27301509
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26582348
47* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25995827
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25835175
49* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25225504
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25082636
51* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24322284
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23296826
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.22579237
54JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22414983
55* SOX2_20726797_ChIP-Seq_SW620_Human1.22013945
56TP53_18474530_ChIP-ChIP_U2OS_Human1.21882027
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20435662
58* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20375351
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19355142
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18932885
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18041173
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18041173
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17235485
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16673105
65TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16124324
66GATA1_22025678_ChIP-Seq_K562_Human1.16009033
67* AHR_22903824_ChIP-Seq_MCF-7_Human1.15612864
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15359813
69* TBX20_22080862_ChIP-Seq_HEART_Mouse1.15296905
70* TBX20_22328084_ChIP-Seq_HEART_Mouse1.15296905
71* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12906595
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12867440
73SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12684450
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.12537368
75* FOXO3_23340844_ChIP-Seq_DLD1_Human1.12237291
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11701600
77BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10945017
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09236336
79* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08828041
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.08768780
81WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08300346
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07537887
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.07039040
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06547689
85TP63_23658742_ChIP-Seq_EP156T_Human1.06233326
86TP53_16413492_ChIP-PET_HCT116_Human1.05746540
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05654062
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04980204
89AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04731346
90* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03113261
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02445280
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02181081
93* ARNT_22903824_ChIP-Seq_MCF-7_Human1.02161489
94* SMAD4_21799915_ChIP-Seq_A2780_Human1.01938862
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01192603
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99433679
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98968413
98ISL1_27105846_Chip-Seq_CPCs_Mouse0.98775587
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98710994
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98244565
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98050354
102* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97386678
103* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97248966
104STAT3_23295773_ChIP-Seq_U87_Human0.96001373
105TCF4_18268006_ChIP-ChIP_LS174T_Human0.95755658
106* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95089953
107* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93562010
108SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92274074
109CDX2_20551321_ChIP-Seq_CACO-2_Human0.90812863
110RXR_22108803_ChIP-Seq_LS180_Human0.90576538
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90478579
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90468701
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90128514
114EZH2_27294783_Chip-Seq_ESCs_Mouse0.89017530
115JARID2_20075857_ChIP-Seq_MESCs_Mouse0.88676732
116SMAD3_21741376_ChIP-Seq_EPCs_Human0.87627770
117* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87588182
118* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87491867
119EZH2_22144423_ChIP-Seq_EOC_Human0.87451432
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86507418
121DROSHA_22980978_ChIP-Seq_HELA_Human0.86409668
122* SOX2_21211035_ChIP-Seq_LN229_Gbm0.86053969
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85099252
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84708183
125* SMAD3_21741376_ChIP-Seq_HESCs_Human0.84517904
126SMAD4_21741376_ChIP-Seq_EPCs_Human0.84311029
127* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83788217
128RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83296056
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83028336
130GATA4_25053715_ChIP-Seq_YYC3_Human0.82770568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.38592169
2MP0008438_abnormal_cutaneous_collagen3.85007864
3MP0005360_urolithiasis3.60563381
4MP0005365_abnormal_bile_salt3.07515963
5MP0002837_dystrophic_cardiac_calcinosis3.02638127
6MP0004272_abnormal_basement_membrane3.00286683
7MP0005085_abnormal_gallbladder_physiolo2.98335963
8MP0003252_abnormal_bile_duct2.92740860
9MP0003195_calcinosis2.55481312
10MP0009379_abnormal_foot_pigmentation2.45865173
11MP0009384_cardiac_valve_regurgitation2.44079069
12MP0003705_abnormal_hypodermis_morpholog2.43002494
13MP0006054_spinal_hemorrhage2.40385330
14MP0003566_abnormal_cell_adhesion2.36059637
15MP0010368_abnormal_lymphatic_system2.31188069
16MP0009780_abnormal_chondrocyte_physiolo2.23487888
17MP0008875_abnormal_xenobiotic_pharmacok2.17605628
18MP0005083_abnormal_biliary_tract2.12408399
19MP0005275_abnormal_skin_tensile2.11427357
20MP0003279_aneurysm1.90024821
21MP0001542_abnormal_bone_strength1.80486940
22MP0001666_abnormal_nutrient_absorption1.78009275
23MP0003045_fibrosis1.77570194
24MP0002295_abnormal_pulmonary_circulatio1.74517773
25MP0005023_abnormal_wound_healing1.73210780
26MP0005503_abnormal_tendon_morphology1.67103985
27MP0003950_abnormal_plasma_membrane1.65029618
28MP0010329_abnormal_lipoprotein_level1.64287301
29MP0000013_abnormal_adipose_tissue1.60878873
30MP0002877_abnormal_melanocyte_morpholog1.58091851
31MP0003868_abnormal_feces_composition1.54476811
32MP0003941_abnormal_skin_development1.51696956
33MP0002168_other_aberrant_phenotype1.50684802
34MP0005408_hypopigmentation1.47831193
35MP0003828_pulmonary_edema1.41914530
36MP0005167_abnormal_blood-brain_barrier1.40193340
37MP0001879_abnormal_lymphatic_vessel1.39471243
38MP0010352_gastrointestinal_tract_polyps1.37603500
39MP0005220_abnormal_exocrine_pancreas1.36992917
40MP0002118_abnormal_lipid_homeostasis1.33654427
41MP0005623_abnormal_meninges_morphology1.32845966
42MP0001958_emphysema1.32162436
43MP0005332_abnormal_amino_acid1.31066983
44MP0006138_congestive_heart_failure1.29548659
45MP0005084_abnormal_gallbladder_morpholo1.28794959
46MP0005670_abnormal_white_adipose1.27810023
47MP0001299_abnormal_eye_distance/1.25927499
48MP0000759_abnormal_skeletal_muscle1.25786366
49MP0004270_analgesia1.24911488
50MP0005171_absent_coat_pigmentation1.24249871
51MP0010386_abnormal_urinary_bladder1.23870512
52MP0002138_abnormal_hepatobiliary_system1.23136525
53MP0000751_myopathy1.22462103
54MP0004130_abnormal_muscle_cell1.19754659
55MP0002108_abnormal_muscle_morphology1.18194266
56MP0003191_abnormal_cellular_cholesterol1.17744702
57MP0003806_abnormal_nucleotide_metabolis1.17433084
58MP0000920_abnormal_myelination1.15675444
59MP0002896_abnormal_bone_mineralization1.14900244
60MP0000767_abnormal_smooth_muscle1.14302695
61MP0002249_abnormal_larynx_morphology1.14078796
62MP0005164_abnormal_response_to1.11794296
63MP0009250_abnormal_appendicular_skeleto1.10532819
64MP0003300_gastrointestinal_ulcer1.08869718
65MP0005409_darkened_coat_color1.06024584
66MP0000003_abnormal_adipose_tissue1.03896915
67MP0000749_muscle_degeneration1.02926781
68MP0000534_abnormal_ureter_morphology1.02186225
69MP0003283_abnormal_digestive_organ1.01727167
70MP0000762_abnormal_tongue_morphology1.00914642
71MP0004185_abnormal_adipocyte_glucose0.99796007
72MP0005595_abnormal_vascular_smooth0.97812789
73MP0009840_abnormal_foam_cell0.97748271
74MP0001661_extended_life_span0.97482994
75MP0004883_abnormal_blood_vessel0.96423473
76MP0004084_abnormal_cardiac_muscle0.93962901
77MP0008775_abnormal_heart_ventricle0.91820719
78MP0005395_other_phenotype0.91755395
79MP0000462_abnormal_digestive_system0.90513126
80MP0004036_abnormal_muscle_relaxation0.90222126
81MP0000579_abnormal_nail_morphology0.90070644
82MP0001944_abnormal_pancreas_morphology0.89881620
83MP0000609_abnormal_liver_physiology0.88496563
84MP0002928_abnormal_bile_duct0.88413523
85MP0002876_abnormal_thyroid_physiology0.88289477
86MP0002254_reproductive_system_inflammat0.88221790
87MP0002060_abnormal_skin_morphology0.87961833
88MP0005330_cardiomyopathy0.87268671
89MP0003385_abnormal_body_wall0.86881365
90MP0005666_abnormal_adipose_tissue0.85967140
91MP0005375_adipose_tissue_phenotype0.85580558
92MP0009643_abnormal_urine_homeostasis0.84397175
93MP0005451_abnormal_body_composition0.83577646
94MP0002332_abnormal_exercise_endurance0.83253919
95MP0004043_abnormal_pH_regulation0.82590706
96MP0003091_abnormal_cell_migration0.82474920
97MP0000733_abnormal_muscle_development0.81621324
98MP0004510_myositis0.80703087
99MP0002971_abnormal_brown_adipose0.80636542
100MP0010234_abnormal_vibrissa_follicle0.80165323
101MP0005369_muscle_phenotype0.79948881
102MP0005508_abnormal_skeleton_morphology0.79902815
103MP0004087_abnormal_muscle_fiber0.78324664
104MP0001614_abnormal_blood_vessel0.77610057
105MP0002269_muscular_atrophy0.77059782
106MP0001915_intracranial_hemorrhage0.76278559
107MP0004215_abnormal_myocardial_fiber0.76193722
108MP0005620_abnormal_muscle_contractility0.74854407
109MP0000230_abnormal_systemic_arterial0.74844425
110MP0004484_altered_response_of0.74646585
111MP0000678_abnormal_parathyroid_gland0.74498971
112MP0002078_abnormal_glucose_homeostasis0.74107842
113MP0000750_abnormal_muscle_regeneration0.73848827
114MP0002972_abnormal_cardiac_muscle0.73811040
115MP0004233_abnormal_muscle_weight0.73040829
116MP0003690_abnormal_glial_cell0.72968210
117MP0005257_abnormal_intraocular_pressure0.72688163
118MP0004145_abnormal_muscle_electrophysio0.72285570
119MP0002133_abnormal_respiratory_system0.72166054
120MP0005388_respiratory_system_phenotype0.72166054
121MP0003329_amyloid_beta_deposits0.71437803
122MP0001188_hyperpigmentation0.71109426
123MP0000747_muscle_weakness0.69748713
124MP0008004_abnormal_stomach_pH0.69691163
125MP0005165_increased_susceptibility_to0.69260052
126MP0001243_abnormal_dermal_layer0.68748938
127MP0002933_joint_inflammation0.68534631
128MP0010030_abnormal_orbit_morphology0.68017941
129MP0002128_abnormal_blood_circulation0.66729552
130MP0002106_abnormal_muscle_physiology0.66495085
131MP0003942_abnormal_urinary_system0.66322006
132MP0002127_abnormal_cardiovascular_syste0.65792568
133MP0000163_abnormal_cartilage_morphology0.65405025
134MP0001756_abnormal_urination0.63926656
135MP0000249_abnormal_blood_vessel0.63113957
136MP0002925_abnormal_cardiovascular_devel0.63026383
137MP0002115_abnormal_skeleton_extremities0.62540820
138MP0003755_abnormal_palate_morphology0.62123075
139MP0003935_abnormal_craniofacial_develop0.62077624
140MP0010630_abnormal_cardiac_muscle0.61167607
141MP0005385_cardiovascular_system_phenoty0.59659161
142MP0001544_abnormal_cardiovascular_syste0.59659161
143MP0000343_altered_response_to0.59465250
144MP0004858_abnormal_nervous_system0.58270757

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.84493390
2Intrahepatic cholestasis (HP:0001406)4.42728334
3Premature rupture of membranes (HP:0001788)3.94167887
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.70723922
5Hypoglycemic coma (HP:0001325)3.62023683
6Xanthomatosis (HP:0000991)3.42948005
7Popliteal pterygium (HP:0009756)3.34043373
8Hypoalphalipoproteinemia (HP:0003233)3.09823316
9Protrusio acetabuli (HP:0003179)2.95221622
10Ulnar claw (HP:0001178)2.90348155
11Hyperglycemia (HP:0003074)2.89477463
12Abnormality of the common coagulation pathway (HP:0010990)2.88109724
13Round ear (HP:0100830)2.84478679
14Broad metatarsal (HP:0001783)2.84359204
15Follicular hyperkeratosis (HP:0007502)2.83902091
16Hypoglycemic seizures (HP:0002173)2.77611606
17Abnormality of the intrinsic pathway (HP:0010989)2.77099890
18Complement deficiency (HP:0004431)2.76278966
19Hyperinsulinemic hypoglycemia (HP:0000825)2.75433902
20Neonatal short-limb short stature (HP:0008921)2.72045358
21Cervical subluxation (HP:0003308)2.71894741
22Abnormality of monocarboxylic acid metabolism (HP:0010996)2.69716705
23Increased connective tissue (HP:0009025)2.61970374
24Abnormality of the ischium (HP:0003174)2.61558110
25Muscle fiber splitting (HP:0003555)2.54856133
26Atrophic scars (HP:0001075)2.54376275
27Spondylolisthesis (HP:0003302)2.53243167
28Ketosis (HP:0001946)2.51652014
29Osteolytic defects of the hand bones (HP:0009699)2.51340019
30Osteolytic defects of the phalanges of the hand (HP:0009771)2.51340019
31Prolonged partial thromboplastin time (HP:0003645)2.51318889
32Hypoplasia of the iris (HP:0007676)2.50802547
33Dilatation of the ascending aorta (HP:0005111)2.47094176
34Distal lower limb muscle weakness (HP:0009053)2.46342116
35Ketoacidosis (HP:0001993)2.46029692
36Aortic regurgitation (HP:0001659)2.45567942
37Fat malabsorption (HP:0002630)2.44054653
38Aortic dissection (HP:0002647)2.42131963
39Skin nodule (HP:0200036)2.41528067
40Insulin-resistant diabetes mellitus (HP:0000831)2.40595237
41Aplasia of the musculature (HP:0100854)2.39919871
42Hypolipoproteinemia (HP:0010981)2.39768851
43Hyporeflexia of lower limbs (HP:0002600)2.38352906
44Hypoplastic ischia (HP:0003175)2.36463295
45Hyperlipoproteinemia (HP:0010980)2.35590478
46Cardiovascular calcification (HP:0011915)2.35260325
47Abnormality of dentin (HP:0010299)2.35051400
48Spinal rigidity (HP:0003306)2.33403353
49Asymmetric septal hypertrophy (HP:0001670)2.31818251
50Limited hip movement (HP:0008800)2.30668844
51Myocardial infarction (HP:0001658)2.27411750
52Insidious onset (HP:0003587)2.23521950
53Termporal pattern (HP:0011008)2.23521950
54Infantile muscular hypotonia (HP:0008947)2.20804769
55Turricephaly (HP:0000262)2.19842879
56Scapular winging (HP:0003691)2.15499875
57Onion bulb formation (HP:0003383)2.15192534
58Epidermoid cyst (HP:0200040)2.14592424
59Gowers sign (HP:0003391)2.12513447
60Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12187103
61Aneurysm (HP:0002617)2.10663276
62Aortic aneurysm (HP:0004942)2.09632293
63Ankle contracture (HP:0006466)2.09328987
64Aortic valve stenosis (HP:0001650)2.06716546
65Mitral valve prolapse (HP:0001634)2.05911246
66Segmental peripheral demyelination/remyelination (HP:0003481)2.05823582
67Conjugated hyperbilirubinemia (HP:0002908)2.05273379
68Knee flexion contracture (HP:0006380)2.04047121
69Wide anterior fontanel (HP:0000260)2.03972940
70Vertebral compression fractures (HP:0002953)2.03707287
71Cerebral aneurysm (HP:0004944)2.03351050
72Shallow orbits (HP:0000586)2.03080906
73Difficulty running (HP:0009046)2.02748604
74Abnormality of skeletal muscle fiber size (HP:0012084)2.00576106
75Abnormality of complement system (HP:0005339)1.98195222
76Genu recurvatum (HP:0002816)1.97400219
77Natal tooth (HP:0000695)1.97282957
78Neurofibrillary tangles (HP:0002185)1.97226941
79Bradycardia (HP:0001662)1.97088245
80Coronal craniosynostosis (HP:0004440)1.95915109
81Wrist flexion contracture (HP:0001239)1.95540856
82Generalized amyotrophy (HP:0003700)1.94918278
83Mitral regurgitation (HP:0001653)1.94833901
84Sudden death (HP:0001699)1.93254790
85Elbow flexion contracture (HP:0002987)1.93013935
86Amniotic constriction ring (HP:0009775)1.92685954
87Abnormality of placental membranes (HP:0011409)1.92685954
88Hammertoe (HP:0001765)1.92679213
89Mildly elevated creatine phosphokinase (HP:0008180)1.92538486
90Hip contracture (HP:0003273)1.91937537
91Peritonitis (HP:0002586)1.91176774
92Striae distensae (HP:0001065)1.91037892
93Ectopia lentis (HP:0001083)1.90515540
94Potter facies (HP:0002009)1.90355751
95Facial shape deformation (HP:0011334)1.90355751
96Ulnar deviation of the wrist (HP:0003049)1.88761713
97Joint laxity (HP:0001388)1.88417542
98Vascular tortuosity (HP:0004948)1.88386562
99Slender build (HP:0001533)1.88365317
100Pterygium (HP:0001059)1.88150464
101Glucose intolerance (HP:0000833)1.87898113
102Action tremor (HP:0002345)1.87691861
103Hyperammonemia (HP:0001987)1.87195879
104Hyperextensible skin (HP:0000974)1.87168537
105Abnormal delivery (HP:0001787)1.87035123
106Fragile skin (HP:0001030)1.86186437
107Atrial fibrillation (HP:0005110)1.85480018
108Joint stiffness (HP:0001387)1.84932963
109Buphthalmos (HP:0000557)1.83755853
110Abnormal cartilage morphology (HP:0002763)1.83652236
111Symptomatic seizures (HP:0011145)1.83412737
112Camptodactyly of toe (HP:0001836)1.82867110
113Increased variability in muscle fiber diameter (HP:0003557)1.82347019
114Lipoatrophy (HP:0100578)1.82160500
115Short nail (HP:0001799)1.82082424
116Fetal akinesia sequence (HP:0001989)1.81462790
117Abnormality of the calf musculature (HP:0001430)1.81033166
118Pulmonary artery stenosis (HP:0004415)1.80974684
119Soft skin (HP:0000977)1.80740997
120Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.80734884
121Abnormality of methionine metabolism (HP:0010901)1.80475430
122Aplasia involving bones of the extremities (HP:0009825)1.79983732
123Aplasia involving bones of the upper limbs (HP:0009823)1.79983732
124Aplasia of the phalanges of the hand (HP:0009802)1.79983732
125Polycythemia (HP:0001901)1.79950769
126Hypobetalipoproteinemia (HP:0003563)1.79776848
127Abnormality of the acetabulum (HP:0003170)1.77265109
128Bowel diverticulosis (HP:0005222)1.76189860
129Nonimmune hydrops fetalis (HP:0001790)1.74845465
130Bundle branch block (HP:0011710)1.74791974
131Insulin resistance (HP:0000855)1.74747828
132Distal upper limb amyotrophy (HP:0007149)1.74340189
133Upper limb amyotrophy (HP:0009129)1.74340189
134Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.73652766
135Mitral stenosis (HP:0001718)1.73432778
136Ovoid vertebral bodies (HP:0003300)1.73255409
137Limb-girdle muscle atrophy (HP:0003797)1.73159278
138Nemaline bodies (HP:0003798)1.73013615
139Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72467855
140Overgrowth (HP:0001548)1.72433624
141Right ventricular cardiomyopathy (HP:0011663)1.70791914
142Hypercholesterolemia (HP:0003124)1.70374883
143Blue sclerae (HP:0000592)1.70159443
144Reduced subcutaneous adipose tissue (HP:0003758)1.69737882
145Distal arthrogryposis (HP:0005684)1.69467457
146Abnormality of glycine metabolism (HP:0010895)1.69284274
147Abnormality of serine family amino acid metabolism (HP:0010894)1.69284274
148Venous abnormality (HP:0002624)1.68998223
149Abnormality of the neuromuscular junction (HP:0003398)1.68152342
150Fatigable weakness (HP:0003473)1.68152342
151Vascular calcification (HP:0004934)1.68151546
152Abnormality of the anterior chamber (HP:0000593)1.67621083
153Wormian bones (HP:0002645)1.67297357
154Abnormality of sulfur amino acid metabolism (HP:0004339)1.67108421
155Arterial tortuosity (HP:0005116)1.65963196
156Esophageal varix (HP:0002040)1.65711588
157Venous insufficiency (HP:0005293)1.65348278
158Bladder diverticulum (HP:0000015)1.65304295
159Pancreatitis (HP:0001733)1.63567137
160Cerebral hemorrhage (HP:0001342)1.63354618
161Thin ribs (HP:0000883)1.62640844
162Type 1 muscle fiber predominance (HP:0003803)1.62131271
163Acanthosis nigricans (HP:0000956)1.62091621
164Mucopolysacchariduria (HP:0008155)1.61256234
165Urinary glycosaminoglycan excretion (HP:0003541)1.61256234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS12.96493078
2RIPK12.82398595
3SIK12.71781966
4INSRR2.71261748
5TIE12.68904103
6BCKDK2.60632103
7EPHB12.52011968
8TRIB32.25873816
9FGFR42.22326165
10PDGFRA2.09371122
11MET2.09028667
12EPHA32.08287815
13WNK42.08171831
14TTN1.93774578
15MUSK1.91889576
16DDR21.84648411
17PAK31.75907909
18EPHB21.69006396
19ERBB41.68361547
20NTRK11.61149461
21TAOK31.60623104
22STK391.54968724
23FGFR21.51892188
24PTK21.40453338
25FER1.31454594
26RET1.31192594
27LATS21.30824547
28ERN11.28308772
29MOS1.27625146
30PRKD31.27496097
31TESK11.26341423
32WNK11.24752125
33STK381.24237502
34MAP3K91.19826306
35PDGFRB1.19277959
36ERBB21.16627608
37MAP3K21.14240915
38FRK1.09291668
39KSR21.05810410
40STK38L1.04302639
41PTK61.03444105
42TGFBR21.03232889
43MAP3K31.00078606
44MAPK150.99686878
45PIK3CA0.99364701
46PRKAA20.96926790
47LMTK20.95226903
48ARAF0.94186246
49MAPK70.91898382
50PAK40.91448067
51PTK2B0.91068953
52CAMK1D0.90638221
53MAP2K10.90416105
54ROCK10.89044261
55PRKCH0.88243021
56MAP3K120.86485000
57DMPK0.86257019
58TRPM70.86084616
59PRKD10.86057392
60MARK20.85562868
61STK30.82403031
62EPHA20.82100878
63PAK60.81642873
64MST1R0.80392104
65KDR0.80250937
66SGK4940.79839380
67SGK2230.79839380
68MARK10.78588381
69DAPK30.78381087
70CAMK1G0.78073000
71MTOR0.75987752
72CDC42BPA0.75209008
73GSK3A0.74965070
74PKN10.74662257
75MAP3K130.74286410
76PAK20.73732573
77MELK0.72751327
78PRKCE0.71778892
79PKN20.71321212
80AKT30.70987115
81PNCK0.70007223
82MAPKAPK30.69736628
83NEK90.69686674
84PRKAA10.68854696
85RPS6KA20.68706413
86TYRO30.67727502
87OBSCN0.66607385
88PRKD20.64560104
89ROCK20.63849115
90JAK10.63117363
91CAMK2D0.62520922
92MAP3K10.62321866
93PHKG20.60089240
94PHKG10.60089240
95LIMK10.60000539
96ILK0.59355731
97ABL20.59312753
98PINK10.58863251
99NLK0.58667692
100IRAK10.57340548
101MAP3K60.56451689
102ICK0.52991811
103MYLK0.52331882
104CSNK1A1L0.52224928
105PIK3CG0.51917047
106FGFR30.50658918
107IGF1R0.50014239
108MAP2K20.49893843
109CSNK1G10.49483013
110CAMK2B0.49250382
111OXSR10.49238979
112CAMK2A0.49059454
113MAP3K70.48403495
114NEK60.48191457
115BCR0.48156322
116CDK90.47373932
117DAPK20.46238661
118INSR0.46067615
119CAMK2G0.44217408
120ADRBK10.42548114
121GRK50.42136781
122KSR10.42033019
123MAPK120.41951407
124TGFBR10.40728876
125PRKG20.40695446
126SGK30.40613989
127CDK80.39482959
128GRK10.39472067
129IRAK30.38939816
130PDPK10.36893433
131AKT20.36216526
132CCNB10.36026946
133MAPKAPK50.35845679
134NTRK30.35468952

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.13651196
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.88722210
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.56022037
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31823833
5Fatty acid degradation_Homo sapiens_hsa000712.16402119
6Tryptophan metabolism_Homo sapiens_hsa003802.16222639
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12189294
8Propanoate metabolism_Homo sapiens_hsa006401.99087220
9Arginine biosynthesis_Homo sapiens_hsa002201.97652223
10Complement and coagulation cascades_Homo sapiens_hsa046101.93602415
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.91667669
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89006005
13Sulfur metabolism_Homo sapiens_hsa009201.87299030
14Fatty acid metabolism_Homo sapiens_hsa012121.86773996
15Butanoate metabolism_Homo sapiens_hsa006501.84792464
16PPAR signaling pathway_Homo sapiens_hsa033201.76929174
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.71221874
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.64547969
19ECM-receptor interaction_Homo sapiens_hsa045121.60224889
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55632856
21Fatty acid elongation_Homo sapiens_hsa000621.54388839
22Steroid biosynthesis_Homo sapiens_hsa001001.53328414
23Bile secretion_Homo sapiens_hsa049761.46250588
24Peroxisome_Homo sapiens_hsa041461.45486590
25Renin secretion_Homo sapiens_hsa049241.42250637
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.41362410
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40521713
28Fat digestion and absorption_Homo sapiens_hsa049751.40258819
29Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39565642
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34257481
31Histidine metabolism_Homo sapiens_hsa003401.32999761
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30527397
33Protein digestion and absorption_Homo sapiens_hsa049741.30508394
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28430700
35ABC transporters_Homo sapiens_hsa020101.22971552
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21844784
37Fatty acid biosynthesis_Homo sapiens_hsa000611.17095212
38Tyrosine metabolism_Homo sapiens_hsa003501.16641094
39Hippo signaling pathway_Homo sapiens_hsa043901.14448354
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14383578
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11185272
42beta-Alanine metabolism_Homo sapiens_hsa004101.10116236
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08667384
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08337124
45Focal adhesion_Homo sapiens_hsa045101.06448631
46Small cell lung cancer_Homo sapiens_hsa052221.04992520
47Steroid hormone biosynthesis_Homo sapiens_hsa001400.98945457
48Pyruvate metabolism_Homo sapiens_hsa006200.98272447
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98230748
50Arginine and proline metabolism_Homo sapiens_hsa003300.96916206
51Starch and sucrose metabolism_Homo sapiens_hsa005000.96909027
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95955638
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94710136
54Melanoma_Homo sapiens_hsa052180.94363053
55MicroRNAs in cancer_Homo sapiens_hsa052060.93937940
56Estrogen signaling pathway_Homo sapiens_hsa049150.93697938
57Vitamin B6 metabolism_Homo sapiens_hsa007500.92286738
58Glycerolipid metabolism_Homo sapiens_hsa005610.92161771
59Chemical carcinogenesis_Homo sapiens_hsa052040.90692149
60Other glycan degradation_Homo sapiens_hsa005110.89997766
61Salivary secretion_Homo sapiens_hsa049700.89344470
62Dilated cardiomyopathy_Homo sapiens_hsa054140.88928314
63Phenylalanine metabolism_Homo sapiens_hsa003600.88781965
64Protein export_Homo sapiens_hsa030600.88469952
65Sphingolipid metabolism_Homo sapiens_hsa006000.87236793
66Ovarian steroidogenesis_Homo sapiens_hsa049130.86931002
67Glioma_Homo sapiens_hsa052140.86893218
68Mineral absorption_Homo sapiens_hsa049780.85658629
69Pancreatic secretion_Homo sapiens_hsa049720.84782817
70Dorso-ventral axis formation_Homo sapiens_hsa043200.84773014
71Oxytocin signaling pathway_Homo sapiens_hsa049210.83865789
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83808312
73Adherens junction_Homo sapiens_hsa045200.83762675
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83750682
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83095089
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83073223
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82614007
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82221515
79Lysine degradation_Homo sapiens_hsa003100.81728522
80Gastric acid secretion_Homo sapiens_hsa049710.81721571
81Insulin secretion_Homo sapiens_hsa049110.81003573
82Calcium signaling pathway_Homo sapiens_hsa040200.80933807
83Retinol metabolism_Homo sapiens_hsa008300.80234976
84Insulin resistance_Homo sapiens_hsa049310.80220721
85Rap1 signaling pathway_Homo sapiens_hsa040150.79894100
86GnRH signaling pathway_Homo sapiens_hsa049120.79630314
87Folate biosynthesis_Homo sapiens_hsa007900.79044504
88Amoebiasis_Homo sapiens_hsa051460.78767471
89Caffeine metabolism_Homo sapiens_hsa002320.77891688
90Selenocompound metabolism_Homo sapiens_hsa004500.76590085
91Melanogenesis_Homo sapiens_hsa049160.76297411
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.76225992
93Glutamatergic synapse_Homo sapiens_hsa047240.74924647
94Vibrio cholerae infection_Homo sapiens_hsa051100.72771001
95cAMP signaling pathway_Homo sapiens_hsa040240.71626947
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70469304
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70232909
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68373778
99Bladder cancer_Homo sapiens_hsa052190.68160690
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68084672
101Pathways in cancer_Homo sapiens_hsa052000.67761715
102Prion diseases_Homo sapiens_hsa050200.65585716
103Circadian entrainment_Homo sapiens_hsa047130.65549995
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65468883
105Staphylococcus aureus infection_Homo sapiens_hsa051500.64034507
106Lysosome_Homo sapiens_hsa041420.63512716
107Vitamin digestion and absorption_Homo sapiens_hsa049770.61413862
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60951576
109GABAergic synapse_Homo sapiens_hsa047270.60703484
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60343760
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59178332
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.58425785
113Endocytosis_Homo sapiens_hsa041440.58001995
114Linoleic acid metabolism_Homo sapiens_hsa005910.55814457
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55310062
116Tight junction_Homo sapiens_hsa045300.55045392
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.54771667
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.53760191
119Amphetamine addiction_Homo sapiens_hsa050310.52753813
120Long-term potentiation_Homo sapiens_hsa047200.52510251
121Proteoglycans in cancer_Homo sapiens_hsa052050.51577041
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51376574
123MAPK signaling pathway_Homo sapiens_hsa040100.50358177
124Hedgehog signaling pathway_Homo sapiens_hsa043400.50036746
125Long-term depression_Homo sapiens_hsa047300.49158292
126Malaria_Homo sapiens_hsa051440.49068878
127Ether lipid metabolism_Homo sapiens_hsa005650.48804862
128Thyroid hormone synthesis_Homo sapiens_hsa049180.48462508
129Axon guidance_Homo sapiens_hsa043600.47416523
130Pertussis_Homo sapiens_hsa051330.46922107
131FoxO signaling pathway_Homo sapiens_hsa040680.46562472
132Renal cell carcinoma_Homo sapiens_hsa052110.46404430
133Chronic myeloid leukemia_Homo sapiens_hsa052200.45822987
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45236465
135Cholinergic synapse_Homo sapiens_hsa047250.44927981
136Circadian rhythm_Homo sapiens_hsa047100.44410185
137ErbB signaling pathway_Homo sapiens_hsa040120.44381160
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43755595
139AMPK signaling pathway_Homo sapiens_hsa041520.43669660
140TGF-beta signaling pathway_Homo sapiens_hsa043500.43200058
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43085319
142Platelet activation_Homo sapiens_hsa046110.41979941
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40503158
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38806077
145Glucagon signaling pathway_Homo sapiens_hsa049220.36691127
146Carbon metabolism_Homo sapiens_hsa012000.34747540
147Cocaine addiction_Homo sapiens_hsa050300.33615323
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33236725
149Type II diabetes mellitus_Homo sapiens_hsa049300.33009610
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30700615
151Phospholipase D signaling pathway_Homo sapiens_hsa040720.29422755
152Glycerophospholipid metabolism_Homo sapiens_hsa005640.27329055
153Ras signaling pathway_Homo sapiens_hsa040140.26759572
154Gap junction_Homo sapiens_hsa045400.26296267
155Prostate cancer_Homo sapiens_hsa052150.26155392

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