STARD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting cholesterol. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)9.36552492
2daunorubicin metabolic process (GO:0044597)9.36552492
3polyketide metabolic process (GO:0030638)9.36552492
4aminoglycoside antibiotic metabolic process (GO:0030647)6.05163846
5maintenance of protein location in nucleus (GO:0051457)5.97712965
6regulation of response to osmotic stress (GO:0047484)5.34772159
7regulation of MHC class I biosynthetic process (GO:0045343)4.48885013
8regulation of mammary gland epithelial cell proliferation (GO:0033599)4.47842454
9interferon-gamma production (GO:0032609)4.38395696
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33572437
11negative regulation of cell killing (GO:0031342)4.33572437
12cytidine metabolic process (GO:0046087)4.28609292
13cytidine catabolic process (GO:0006216)4.28609292
14cytidine deamination (GO:0009972)4.28609292
15somite rostral/caudal axis specification (GO:0032525)4.27999003
16muscle organ morphogenesis (GO:0048644)4.25399880
17negative regulation of erythrocyte differentiation (GO:0045647)4.19942458
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.19399344
19positive regulation of gamma-delta T cell activation (GO:0046645)4.13473220
20regulation of T-helper 2 cell differentiation (GO:0045628)4.06202492
21antigen processing and presentation of endogenous antigen (GO:0019883)4.04556171
22immunoglobulin mediated immune response (GO:0016064)3.99512017
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.86122129
24negative regulation of epidermis development (GO:0045683)3.83925222
25nucleoside transmembrane transport (GO:1901642)3.82819553
26response to dietary excess (GO:0002021)3.82438928
27hormone catabolic process (GO:0042447)3.79788202
28positive thymic T cell selection (GO:0045059)3.79149586
29positive regulation of defense response to virus by host (GO:0002230)3.76666745
30leukocyte aggregation (GO:0070486)3.75724693
31regulation of telomere maintenance via telomerase (GO:0032210)3.73053516
32rRNA transcription (GO:0009303)3.72693404
33coenzyme catabolic process (GO:0009109)3.72361613
34negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.68519673
35negative regulation of telomerase activity (GO:0051974)3.65927127
36establishment of endothelial barrier (GO:0061028)3.65636253
37phagocytosis, recognition (GO:0006910)3.54556301
38negative regulation of cell cycle G2/M phase transition (GO:1902750)3.51984674
39detection of other organism (GO:0098543)3.50675050
40detection of bacterium (GO:0016045)3.50334803
41negative regulation of viral release from host cell (GO:1902187)3.47872762
42mannose metabolic process (GO:0006013)3.40266385
43regulation of gamma-delta T cell activation (GO:0046643)3.36719335
44neutrophil activation involved in immune response (GO:0002283)3.36166923
45positive regulation of protein deacetylation (GO:0090312)3.33166229
46maintenance of protein localization in organelle (GO:0072595)3.32286891
47axon ensheathment in central nervous system (GO:0032291)3.32182860
48central nervous system myelination (GO:0022010)3.32182860
49histone H4-K12 acetylation (GO:0043983)3.31628458
50positive regulation of macrophage cytokine production (GO:0060907)3.29567239
51positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.28078732
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.26313972
53intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.26151488
54NIK/NF-kappaB signaling (GO:0038061)3.24813141
55quinone metabolic process (GO:1901661)3.24295510
56macrophage activation involved in immune response (GO:0002281)3.23037527
57regulation of nuclear cell cycle DNA replication (GO:0033262)3.20641353
58branching involved in mammary gland duct morphogenesis (GO:0060444)3.20382910
59regulation of apoptotic process involved in morphogenesis (GO:1902337)3.20076321
60histone H4-K8 acetylation (GO:0043982)3.18930002
61histone H4-K5 acetylation (GO:0043981)3.18930002
62regulation of gamma-delta T cell differentiation (GO:0045586)3.17923402
63response to muramyl dipeptide (GO:0032495)3.17716395
64positive regulation of tissue remodeling (GO:0034105)3.15842073
65pyrimidine ribonucleoside catabolic process (GO:0046133)3.15803652
66thymic T cell selection (GO:0045061)3.12041324
67barbed-end actin filament capping (GO:0051016)3.11386768
68positive regulation of interleukin-17 production (GO:0032740)3.10578430
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09916449
70regulation of translation in response to stress (GO:0043555)3.09064559
71negative regulation of interleukin-12 production (GO:0032695)3.08690894
72regulation of leukocyte degranulation (GO:0043300)3.08105629
73membrane protein intracellular domain proteolysis (GO:0031293)3.06961641
74protein localization to kinetochore (GO:0034501)3.05334042
75regulation of mast cell degranulation (GO:0043304)3.05063621
76endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.04623017
77regulation of interleukin-2 biosynthetic process (GO:0045076)3.02830782
78cellular modified amino acid catabolic process (GO:0042219)3.02059394
79Rap protein signal transduction (GO:0032486)3.01800569
80positive regulation of chemokine biosynthetic process (GO:0045080)3.01565869
81regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.01128313
82response to peptidoglycan (GO:0032494)3.00404101
83icosanoid secretion (GO:0032309)3.00318295
84arachidonic acid secretion (GO:0050482)3.00318295
85regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99562511
86germinal center formation (GO:0002467)2.99057320
87cofactor transport (GO:0051181)2.98949257
88mitochondrion distribution (GO:0048311)2.98080552
89negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.95369562
90detection of external biotic stimulus (GO:0098581)2.95326436
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.95309936
92retinoic acid receptor signaling pathway (GO:0048384)2.91880981
93hypotonic response (GO:0006971)2.91771024
94primary alcohol catabolic process (GO:0034310)2.91335900
95myelin maintenance (GO:0043217)2.90745246
96positive regulation of histone deacetylation (GO:0031065)2.90515257
97cofactor catabolic process (GO:0051187)2.89855983
98transepithelial transport (GO:0070633)2.87512756
99negative regulation of interleukin-2 production (GO:0032703)2.87476139
100negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.87437714
101cyclooxygenase pathway (GO:0019371)2.86183976
102heme transport (GO:0015886)2.86134195
103detection of temperature stimulus (GO:0016048)2.85476054
104negative thymic T cell selection (GO:0045060)2.84891612
105positive regulation of odontogenesis (GO:0042482)2.83869391
106B cell mediated immunity (GO:0019724)2.83454474
107regulation of extracellular matrix disassembly (GO:0010715)2.81720120
108response to laminar fluid shear stress (GO:0034616)2.80656205
109negative regulation of epidermal cell differentiation (GO:0045605)2.80446006
110endothelial cell development (GO:0001885)2.79902299
111tachykinin receptor signaling pathway (GO:0007217)2.79188357
112lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77958971
113cell fate commitment involved in formation of primary germ layer (GO:0060795)2.77548047
114positive regulation of type 2 immune response (GO:0002830)2.77239822
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.76989349
116T cell selection (GO:0045058)2.75818558
117regulation of type 2 immune response (GO:0002828)2.75197514
118intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.75053058
119COPI coating of Golgi vesicle (GO:0048205)2.74245151
120Golgi transport vesicle coating (GO:0048200)2.74245151
121natural killer cell differentiation (GO:0001779)2.73871338
122branching involved in labyrinthine layer morphogenesis (GO:0060670)2.73829611
123positive T cell selection (GO:0043368)2.72959775
124positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.72745601
125regulation of cilium movement (GO:0003352)2.71639134
126regulation of dendritic cell antigen processing and presentation (GO:0002604)2.70611975
127adaptation of signaling pathway (GO:0023058)2.70487062
128amino sugar catabolic process (GO:0046348)2.69954494
129positive regulation by symbiont of host defense response (GO:0052509)2.69089944
130modulation by symbiont of host defense response (GO:0052031)2.69089944
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69089944
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69089944
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.69089944
134modulation by symbiont of host immune response (GO:0052553)2.69089944
135nucleoside transport (GO:0015858)2.68928660
136virion attachment to host cell (GO:0019062)2.66898852
137adhesion of symbiont to host cell (GO:0044650)2.66898852
138cellular response to type I interferon (GO:0071357)2.66102070
139type I interferon signaling pathway (GO:0060337)2.66102070
140response to type I interferon (GO:0034340)2.65902637
141pinocytosis (GO:0006907)2.64494514
142negative regulation of type 2 immune response (GO:0002829)2.63813072
143regulation of mast cell activation involved in immune response (GO:0033006)2.63589493
144neutrophil activation (GO:0042119)2.63328837
145protein localization to endosome (GO:0036010)2.62475870
146positive regulation of developmental pigmentation (GO:0048087)2.62224481
147amyloid precursor protein catabolic process (GO:0042987)2.60845350
148regulation of interferon-beta biosynthetic process (GO:0045357)2.60750419
149ensheathment of neurons (GO:0007272)2.60413005
150modulation by virus of host process (GO:0019054)2.60222582
151granulocyte activation (GO:0036230)2.60091684
152modulation by symbiont of host cellular process (GO:0044068)2.59937602
153negative T cell selection (GO:0043383)2.59877321
154Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59544206
155tolerance induction (GO:0002507)2.59352844
156regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57140884
157negative regulation of granulocyte differentiation (GO:0030853)2.55813284
158regulation of superoxide anion generation (GO:0032928)2.55649386
159myeloid dendritic cell differentiation (GO:0043011)2.55521725
160glycosphingolipid catabolic process (GO:0046479)2.55281418
161detection of molecule of bacterial origin (GO:0032490)2.53650477
162regulation of necroptotic process (GO:0060544)2.52914020
163regulation of defense response to virus by virus (GO:0050690)2.51499029
164regulation of ARF GTPase activity (GO:0032312)2.51319649
165detection of biotic stimulus (GO:0009595)2.50694740
166negative regulation of leukocyte mediated immunity (GO:0002704)2.50035308
167negative regulation of innate immune response (GO:0045824)2.49677216
168negative regulation of cytokine production involved in immune response (GO:0002719)2.49017786
169cellular response to thyroid hormone stimulus (GO:0097067)2.47573646
170regulation of regulated secretory pathway (GO:1903305)2.44845846
171epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44485094
172regulation of somitogenesis (GO:0014807)2.44181128
173signal complex assembly (GO:0007172)2.44154751
174regulation of necrotic cell death (GO:0010939)2.44138177
175negative regulation of cell size (GO:0045792)2.43590639
176response to host immune response (GO:0052572)2.41198658
177response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.41198658
1783-UTR-mediated mRNA stabilization (GO:0070935)2.40532644
179negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.40371130
180response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.38822471
181response to host (GO:0075136)2.38822471
182response to host defenses (GO:0052200)2.38822471
183respiratory burst (GO:0045730)2.35076913
184negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.34684864
185pentose-phosphate shunt (GO:0006098)2.34655191
186positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34218354
187antigen processing and presentation via MHC class Ib (GO:0002475)2.33810021
188stress granule assembly (GO:0034063)2.33587359

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.31635665
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.09619130
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.09619130
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.09619130
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.22802654
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.11367635
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.36965428
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.22908546
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.15068240
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13883946
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09261127
12KDM2B_26808549_Chip-Seq_DND41_Human2.07697643
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.07312547
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07112772
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04409668
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.96580144
17IRF8_27001747_Chip-Seq_BMDM_Mouse1.94845519
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94631091
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92230595
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.86077890
21* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85554263
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.81721265
23SCL_19346495_ChIP-Seq_HPC-7_Human1.77622574
24NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76694201
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75114322
26TCF3_18692474_ChIP-Seq_MEFs_Mouse1.74563028
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.66676238
28KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59020373
29* P68_20966046_ChIP-Seq_HELA_Human1.56713502
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54663906
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.54158245
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53431794
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.53152642
34CTCF_27219007_Chip-Seq_ERYTHROID_Human1.51670563
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51578034
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.50616441
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50491048
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50066787
39KDM2B_26808549_Chip-Seq_K562_Human1.49031511
40TET1_21451524_ChIP-Seq_MESCs_Mouse1.47212199
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45336811
42NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44743252
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44505099
44VDR_21846776_ChIP-Seq_THP-1_Human1.43791506
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43746542
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43630355
47IRF1_19129219_ChIP-ChIP_H3396_Human1.42880259
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.42815010
49SPI1_23127762_ChIP-Seq_K562_Human1.42534385
50KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42004651
51* BCL6_27268052_Chip-Seq_Bcells_Human1.40167738
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.38286624
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37961976
54NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.37641862
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.37306944
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.36311132
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.36137331
58* SMC4_20622854_ChIP-Seq_HELA_Human1.34795441
59NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.33550065
60MYC_22102868_ChIP-Seq_BL_Human1.33454473
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33224740
62TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33180606
63* SPI1_23547873_ChIP-Seq_NB4_Human1.33107802
64PU.1_20513432_ChIP-Seq_Bcells_Mouse1.32736287
65* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32405929
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31390097
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31382419
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31207298
69UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29509905
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29298484
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29194829
72* RUNX1_22412390_ChIP-Seq_EML_Mouse1.29073467
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28996804
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27229200
75TCF7_22412390_ChIP-Seq_EML_Mouse1.25358367
76NANOG_18692474_ChIP-Seq_MEFs_Mouse1.25307870
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25168298
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24708374
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24693896
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22528517
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20103705
82CDX2_20551321_ChIP-Seq_CACO-2_Human1.20086272
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19981183
84RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19273246
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19260475
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17936173
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17371764
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15347573
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15212532
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14097321
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13332179
92* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12519279
93NANOG_18692474_ChIP-Seq_MESCs_Mouse1.11947189
94MAF_26560356_Chip-Seq_TH1_Human1.10218728
95ZNF263_19887448_ChIP-Seq_K562_Human1.10034180
96SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08506098
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08397652
98CREB1_26743006_Chip-Seq_LNCaP_Human1.07664459
99GATA1_19941826_ChIP-Seq_K562_Human1.07434156
100LXR_22292898_ChIP-Seq_THP-1_Human1.07255541
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06873450
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.05678774
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04957341
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04923470
105NCOR1_26117541_ChIP-Seq_K562_Human1.04203014
106RACK7_27058665_Chip-Seq_MCF-7_Human1.03786314
107PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03750301
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03313420
109ATF3_27146783_Chip-Seq_COLON_Human1.03132380
110* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02428616
111* BCOR_27268052_Chip-Seq_Bcells_Human1.01915928
112* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01836070
113* CTCF_26484167_Chip-Seq_Bcells_Mouse1.01742856
114* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01651594
115OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00569850
116MYB_26560356_Chip-Seq_TH1_Human1.00257972
117Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99821898
118POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99457271
119TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97799024
120SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97532173
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97220716
122MYB_26560356_Chip-Seq_TH2_Human0.96265952
123CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96250060
124* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95399420
125YY1_21170310_ChIP-Seq_MESCs_Mouse0.94433070
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.93884819
127* TP53_22127205_ChIP-Seq_IMR90_Human0.93809909
128POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93511278
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92700301
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.91052889
131UTX_26944678_Chip-Seq_JUKART_Human0.88226965
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.87401321
133SOX2_18692474_ChIP-Seq_MESCs_Mouse0.87396514
134VDR_24763502_ChIP-Seq_THP-1_Human0.87196576
135RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86636557
136ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86206822
137E2F1_17053090_ChIP-ChIP_MCF-7_Human0.84871017
138E2F7_22180533_ChIP-Seq_HELA_Human0.84663902
139TFEB_21752829_ChIP-Seq_HELA_Human0.84212375
140* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84129215
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.83833471
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83689251
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83082865
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.81918140
145ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80959418
146SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80899074
147NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78984242
148CREB1_15753290_ChIP-ChIP_HEK293T_Human0.78294228
149MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76665292
150MAF_26560356_Chip-Seq_TH2_Human0.76549523
151CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76191291

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation4.05740067
2MP0003011_delayed_dark_adaptation3.91807175
3MP0004858_abnormal_nervous_system3.48522453
4MP0002254_reproductive_system_inflammat3.24453078
5MP0004264_abnormal_extraembryonic_tissu3.08394833
6MP0005075_abnormal_melanosome_morpholog3.01668357
7MP0005451_abnormal_body_composition2.95639517
8MP0008260_abnormal_autophagy2.89490190
9MP0002332_abnormal_exercise_endurance2.67462708
10MP0003300_gastrointestinal_ulcer2.61593287
11MP0009278_abnormal_bone_marrow2.55492323
12MP0003183_abnormal_peptide_metabolism2.38642724
13MP0001835_abnormal_antigen_presentation2.38003006
14MP0009840_abnormal_foam_cell2.35966641
15MP0005058_abnormal_lysosome_morphology2.28960284
16MP0000920_abnormal_myelination2.14192092
17MP0005387_immune_system_phenotype2.07116921
18MP0001790_abnormal_immune_system2.07116921
19MP0003436_decreased_susceptibility_to2.05055448
20MP0009785_altered_susceptibility_to2.00583174
21MP0004510_myositis1.94512013
22MP0005000_abnormal_immune_tolerance1.91163462
23MP0003172_abnormal_lysosome_physiology1.91015643
24MP0005025_abnormal_response_to1.86460495
25MP0003191_abnormal_cellular_cholesterol1.84350215
26MP0003763_abnormal_thymus_physiology1.80879177
27MP0005671_abnormal_response_to1.79484536
28MP0003950_abnormal_plasma_membrane1.75959625
29MP0002148_abnormal_hypersensitivity_rea1.73408559
30MP0000343_altered_response_to1.69609065
31MP0008057_abnormal_DNA_replication1.68562804
32MP0001800_abnormal_humoral_immune1.66723519
33MP0005394_taste/olfaction_phenotype1.64914523
34MP0005499_abnormal_olfactory_system1.64914523
35MP0000685_abnormal_immune_system1.62607624
36MP0002419_abnormal_innate_immunity1.61750113
37MP0003075_altered_response_to1.60170253
38MP0002396_abnormal_hematopoietic_system1.59802036
39MP0006292_abnormal_olfactory_placode1.58093153
40MP0002723_abnormal_immune_serum1.57675597
41MP0003690_abnormal_glial_cell1.56647097
42MP0003705_abnormal_hypodermis_morpholog1.54246316
43MP0005257_abnormal_intraocular_pressure1.54114282
44MP0002452_abnormal_antigen_presenting1.53878266
45MP0003890_abnormal_embryonic-extraembry1.52017557
46MP0001545_abnormal_hematopoietic_system1.45812096
47MP0005397_hematopoietic_system_phenotyp1.45812096
48MP0001819_abnormal_immune_cell1.44921280
49MP0002420_abnormal_adaptive_immunity1.44632346
50MP0002405_respiratory_system_inflammati1.43343778
51MP0003329_amyloid_beta_deposits1.41708676
52MP0002277_abnormal_respiratory_mucosa1.40696486
53MP0001849_ear_inflammation1.36988620
54MP0002653_abnormal_ependyma_morphology1.36334779
55MP0003448_altered_tumor_morphology1.33430988
56MP0006035_abnormal_mitochondrial_morpho1.33335742
57MP0010352_gastrointestinal_tract_polyps1.29613169
58MP0004043_abnormal_pH_regulation1.29142098
59MP0000465_gastrointestinal_hemorrhage1.29128833
60MP0005310_abnormal_salivary_gland1.28983547
61MP0002933_joint_inflammation1.27621476
62MP0005023_abnormal_wound_healing1.25260748
63MP0005076_abnormal_cell_differentiation1.20700554
64MP0001873_stomach_inflammation1.20561675
65MP0003122_maternal_imprinting1.19707883
66MP0000716_abnormal_immune_system1.19350491
67MP0000689_abnormal_spleen_morphology1.15749384
68MP0009333_abnormal_splenocyte_physiolog1.15732218
69MP0003303_peritoneal_inflammation1.15054635
70MP0005167_abnormal_blood-brain_barrier1.14018002
71MP0000703_abnormal_thymus_morphology1.12150652
72MP0004381_abnormal_hair_follicle1.11828676
73MP0003828_pulmonary_edema1.11279670
74MP0000604_amyloidosis1.10534613
75MP0009764_decreased_sensitivity_to1.08635044
76MP0002429_abnormal_blood_cell1.07731431
77MP0003938_abnormal_ear_development1.07147973
78MP0010155_abnormal_intestine_physiology1.06350696
79MP0003866_abnormal_defecation1.03415965
80MP0004947_skin_inflammation1.02962696
81MP0002127_abnormal_cardiovascular_syste1.02681761
82MP0003634_abnormal_glial_cell1.02591710
83MP0003279_aneurysm1.01256420
84MP0008469_abnormal_protein_level1.00554847
85MP0002722_abnormal_immune_system0.99454022
86MP0003091_abnormal_cell_migration0.99108144
87MP0001845_abnormal_inflammatory_respons0.98101212
88MP0002398_abnormal_bone_marrow0.97946836
89MP0003186_abnormal_redox_activity0.97679350
90MP0000678_abnormal_parathyroid_gland0.95893495
91MP0004782_abnormal_surfactant_physiolog0.95829966
92MP0000749_muscle_degeneration0.95448807
93MP0002092_abnormal_eye_morphology0.95166545
94MP0001348_abnormal_lacrimal_gland0.94085153
95MP0000750_abnormal_muscle_regeneration0.93192430
96MP0001533_abnormal_skeleton_physiology0.93052338
97MP0005266_abnormal_metabolism0.92869839
98MP0000490_abnormal_crypts_of0.90919842
99MP0005164_abnormal_response_to0.90223791
100MP0001853_heart_inflammation0.90067735
101MP0004185_abnormal_adipocyte_glucose0.89652404
102MP0003724_increased_susceptibility_to0.89593730
103MP0008874_decreased_physiological_sensi0.88436500
104MP0001293_anophthalmia0.87647155
105MP0003453_abnormal_keratinocyte_physiol0.86789306
106MP0002877_abnormal_melanocyte_morpholog0.86455408
107MP0002132_abnormal_respiratory_system0.86245439
108MP0005166_decreased_susceptibility_to0.86014703
109MP0000858_altered_metastatic_potential0.84865770
110MP0003984_embryonic_growth_retardation0.84345159
111MP0002088_abnormal_embryonic_growth/wei0.84310314
112MP0003795_abnormal_bone_structure0.83640484
113MP0004808_abnormal_hematopoietic_stem0.82563260
114MP0003656_abnormal_erythrocyte_physiolo0.82051222
115MP0004883_abnormal_blood_vessel0.82017190
116MP0001851_eye_inflammation0.81731864
117MP0004957_abnormal_blastocyst_morpholog0.81395947
118MP0001672_abnormal_embryogenesis/_devel0.81199571
119MP0005380_embryogenesis_phenotype0.81199571
120MP0005666_abnormal_adipose_tissue0.78532191
121MP0001958_emphysema0.76847893
122MP0000383_abnormal_hair_follicle0.74433673
123MP0002089_abnormal_postnatal_growth/wei0.72036996
124MP0008004_abnormal_stomach_pH0.71953538
125MP0005464_abnormal_platelet_physiology0.70495738
126MP0000249_abnormal_blood_vessel0.69880271
127MP0005375_adipose_tissue_phenotype0.69099939
128MP0008961_abnormal_basal_metabolism0.68097868
129MP0005390_skeleton_phenotype0.67973887
130MP0000751_myopathy0.67198259
131MP0000313_abnormal_cell_death0.66990180
132MP0002998_abnormal_bone_remodeling0.66806681
133MP0002166_altered_tumor_susceptibility0.66620122
134MP0003566_abnormal_cell_adhesion0.66395125
135MP0009931_abnormal_skin_appearance0.66059200
136MP0002796_impaired_skin_barrier0.65213914

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.97222667
2Multiple enchondromatosis (HP:0005701)4.69398131
3Hypochromic microcytic anemia (HP:0004840)4.65293461
4Abnormality of liposaccharide metabolism (HP:0010968)4.64478177
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.64478177
6Abnormality of glycolipid metabolism (HP:0010969)4.64478177
7Partial duplication of thumb phalanx (HP:0009944)3.86352912
8Hepatoblastoma (HP:0002884)3.84841830
9Elevated erythrocyte sedimentation rate (HP:0003565)3.60748218
10Rib fusion (HP:0000902)3.54119334
11Dysostosis multiplex (HP:0000943)3.43996280
12Abnormality of the lower motor neuron (HP:0002366)3.28530971
13Partial duplication of the phalanx of hand (HP:0009999)3.27589456
14Rectovaginal fistula (HP:0000143)3.23095118
15Rectal fistula (HP:0100590)3.23095118
16Testicular atrophy (HP:0000029)3.13696977
17Sensory axonal neuropathy (HP:0003390)3.09662743
18Fused cervical vertebrae (HP:0002949)3.08520279
19Recurrent abscess formation (HP:0002722)3.07721095
20Systemic lupus erythematosus (HP:0002725)3.05175554
21Abnormality of the salivary glands (HP:0010286)3.00949076
22Increased IgE level (HP:0003212)2.95199852
23Intestinal fistula (HP:0100819)2.94120975
24Anomalous pulmonary venous return (HP:0010772)2.93530074
25Vacuolated lymphocytes (HP:0001922)2.93065681
26Nasal polyposis (HP:0100582)2.90051573
27Aplasia/Hypoplasia of the fovea (HP:0008060)2.89839166
28Hypoplasia of the fovea (HP:0007750)2.89839166
29Abnormality of the nasal mucosa (HP:0000433)2.89103161
30Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.88893081
31Vaginal fistula (HP:0004320)2.87826955
32Eczematoid dermatitis (HP:0000976)2.85021924
33Increased cerebral lipofuscin (HP:0011813)2.84330843
34Axonal loss (HP:0003447)2.80179178
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75177336
36Abnormality of polysaccharide metabolism (HP:0011012)2.75177336
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75177336
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.73606248
39Spastic tetraparesis (HP:0001285)2.71887705
40Abnormality of macrophages (HP:0004311)2.64983870
41Recurrent bacterial skin infections (HP:0005406)2.63039837
42Upper motor neuron abnormality (HP:0002127)2.63021588
43Mucopolysacchariduria (HP:0008155)2.61348030
44Urinary glycosaminoglycan excretion (HP:0003541)2.61348030
45Abnormality of the pulmonary veins (HP:0011718)2.61283023
46Pustule (HP:0200039)2.61173316
47Ependymoma (HP:0002888)2.61170712
48Mediastinal lymphadenopathy (HP:0100721)2.59176717
49Recurrent gram-negative bacterial infections (HP:0005420)2.59111459
50Chronic obstructive pulmonary disease (HP:0006510)2.56598888
51Obstructive lung disease (HP:0006536)2.56598888
52Interstitial pulmonary disease (HP:0006530)2.54862254
53Combined immunodeficiency (HP:0005387)2.52564510
54Distal lower limb amyotrophy (HP:0008944)2.51033913
55Neurofibrillary tangles (HP:0002185)2.47535650
56J-shaped sella turcica (HP:0002680)2.44741428
57Vertebral compression fractures (HP:0002953)2.44492832
58Neoplasm of striated muscle (HP:0009728)2.42756088
59Broad face (HP:0000283)2.40592919
60Reduced antithrombin III activity (HP:0001976)2.40273491
61Cheilitis (HP:0100825)2.38593084
62Periauricular skin pits (HP:0100277)2.36855616
63Preauricular pit (HP:0004467)2.36855616
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36535197
65Recurrent fungal infections (HP:0002841)2.36167097
66Ragged-red muscle fibers (HP:0003200)2.34584779
67Trismus (HP:0000211)2.32438710
68Nuclear cataract (HP:0100018)2.32381726
69Abnormal cartilage morphology (HP:0002763)2.31469465
70Abnormality of the fovea (HP:0000493)2.30871328
71Nasolacrimal duct obstruction (HP:0000579)2.29298571
72Abnormality of the corticospinal tract (HP:0002492)2.27218352
73Increased IgM level (HP:0003496)2.27030565
74Supranuclear gaze palsy (HP:0000605)2.25402027
75Amyotrophic lateral sclerosis (HP:0007354)2.24705878
76Myositis (HP:0100614)2.22999859
77Large earlobe (HP:0009748)2.22070974
78Hypochromic anemia (HP:0001931)2.21972757
79Difficulty running (HP:0009046)2.21782434
80Cerebral aneurysm (HP:0004944)2.20279712
81Preauricular skin tag (HP:0000384)2.20185925
82Increased serum ferritin (HP:0003281)2.19629627
83Increased serum pyruvate (HP:0003542)2.18268874
84Abnormality of glycolysis (HP:0004366)2.18268874
85Distal lower limb muscle weakness (HP:0009053)2.17431397
86Nephroblastoma (Wilms tumor) (HP:0002667)2.17400131
873-Methylglutaconic aciduria (HP:0003535)2.16217309
88Thin bony cortex (HP:0002753)2.16173916
89Petechiae (HP:0000967)2.13242632
90Fasciculations (HP:0002380)2.12555072
91Colitis (HP:0002583)2.11650212
92Polygenic inheritance (HP:0010982)2.09455192
93Amyloidosis (HP:0011034)2.08185331
94Meningitis (HP:0001287)2.06962951
95Prolonged bleeding time (HP:0003010)2.06802703
96Gastrointestinal inflammation (HP:0004386)2.06788089
97Gingivitis (HP:0000230)2.06760066
98Hemorrhage of the eye (HP:0011885)2.06366838
99Horizontal nystagmus (HP:0000666)2.06320581
100Increased connective tissue (HP:0009025)2.06045343
101Cerebral inclusion bodies (HP:0100314)2.05723125
102Abnormality of small intestinal villus morphology (HP:0011472)2.05475399
103Villous atrophy (HP:0011473)2.05475399
104Hepatosplenomegaly (HP:0001433)2.05436979
105Peritonitis (HP:0002586)2.05163115
106Recurrent viral infections (HP:0004429)2.04939443
107Cellulitis (HP:0100658)2.04403659
108Personality changes (HP:0000751)2.04185649
109Hyperacusis (HP:0010780)2.03890575
110Achilles tendon contracture (HP:0001771)2.03055385
111Thoracic kyphosis (HP:0002942)2.02398744
112Spontaneous hematomas (HP:0007420)2.02069201
113Gastrointestinal infarctions (HP:0005244)2.02010846
114Purpura (HP:0000979)2.01748768
115Hyperinsulinemic hypoglycemia (HP:0000825)2.01402004
116Cerebral hypomyelination (HP:0006808)2.00599228
117Glomerulonephritis (HP:0000099)2.00588762
118Epistaxis (HP:0000421)1.99673005
119Rhabdomyosarcoma (HP:0002859)1.99646598
120Stomatitis (HP:0010280)1.99190968
121Loss of speech (HP:0002371)1.98954727
122Chronic otitis media (HP:0000389)1.98688196
123Poor head control (HP:0002421)1.98410554
124Retrobulbar optic neuritis (HP:0100654)1.97992047
125Optic neuritis (HP:0100653)1.97992047
126Prominent occiput (HP:0000269)1.96815760
127Bifid tongue (HP:0010297)1.96438820
128Panhypogammaglobulinemia (HP:0003139)1.96053333
129Premature loss of primary teeth (HP:0006323)1.95963755
130Diminished motivation (HP:0000745)1.95401396
131Embryonal renal neoplasm (HP:0011794)1.95366421
132Orchitis (HP:0100796)1.94905320
133Cervical subluxation (HP:0003308)1.93572054
134Generalized hypotonia (HP:0001290)1.93030791
135Elevated alkaline phosphatase (HP:0003155)1.92844332
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.92371349
137Neuronal loss in central nervous system (HP:0002529)1.92188237
138Slow saccadic eye movements (HP:0000514)1.89131365
139Short humerus (HP:0005792)1.88902128
140Abnormal lung lobation (HP:0002101)1.87481673
141Difficulty walking (HP:0002355)1.87463652
142Joint stiffness (HP:0001387)1.87039080
143Skin tags (HP:0010609)1.86899101
144Recurrent skin infections (HP:0001581)1.86734510
145Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86225398
146Bone pain (HP:0002653)1.85782157
147Abnormality of the thoracic spine (HP:0100711)1.85464474
148Urticaria (HP:0001025)1.85368184
149Inflammation of the large intestine (HP:0002037)1.85224642
150Aplasia/hypoplasia of the humerus (HP:0006507)1.85192927
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.84061801
152Abnormal gallbladder physiology (HP:0012438)1.83943662
153Cholecystitis (HP:0001082)1.83943662
154Progressive muscle weakness (HP:0003323)1.83861062
155Abnormal enzyme/coenzyme activity (HP:0012379)1.83673525
156Apathy (HP:0000741)1.83042259
157Tetraplegia (HP:0002445)1.83008238
158Flat acetabular roof (HP:0003180)1.82161821
159Hypertensive crisis (HP:0100735)1.81878769
160Hypertriglyceridemia (HP:0002155)1.81524419
161Hypergammaglobulinemia (HP:0010702)1.81471110
162Abnormality of alkaline phosphatase activity (HP:0004379)1.81251568
163Obstructive sleep apnea (HP:0002870)1.80461919
164Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.79703917
165Chest pain (HP:0100749)1.77017191
166Metaphyseal cupping (HP:0003021)1.76385757
167Vasculitis (HP:0002633)1.75780750
168Segmental peripheral demyelination/remyelination (HP:0003481)1.73972889
169Reticulocytosis (HP:0001923)1.73094532
170Prolonged neonatal jaundice (HP:0006579)1.72503686
171Asymmetric septal hypertrophy (HP:0001670)1.72355532
172Granulocytopenia (HP:0001913)1.72277805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.02450389
2ERN14.97371412
3GRK53.99921229
4GRK63.83168385
5CSF1R3.57111133
6TGFBR23.47627353
7TRIB33.18340914
8ADRBK22.88809498
9STK102.67969233
10GRK72.63920483
11GRK12.45922343
12SIK12.37851069
13MATK2.21878153
14EPHB12.15608595
15MAPK72.13537835
16TYRO32.10053286
17SMG12.02539591
18MAP2K32.02187124
19RIPK11.95938121
20MAP3K111.90418806
21MOS1.88731303
22WNK11.85886737
23BLK1.80623832
24PAK41.78560502
25TESK11.74805668
26NME21.68495426
27CSK1.57569339
28TAOK11.57248444
29MAP4K11.51230218
30TTN1.48137634
31TNK21.46717008
32SIK31.46456577
33MAP3K31.44873254
34TAOK21.43905880
35KIT1.40947314
36MARK21.39514399
37TESK21.35248636
38TBK11.33392052
39NTRK11.31278814
40TYK21.28059887
41CDC42BPA1.25520574
42MST41.23311936
43MAP3K101.21358469
44PRKG21.20890839
45IKBKB1.19668157
46CAMK41.19626043
47TTK1.16031547
48FES1.13076402
49MAP3K61.09881310
50MAP3K11.09728966
51PKN21.05120126
52SIK21.02368991
53STK391.01796014
54ITK1.01306852
55RIPK40.96909832
56PTK60.95765061
57CLK10.94350931
58ZAP700.93164122
59PBK0.88092371
60HIPK20.86511848
61MST1R0.85407899
62KSR20.83483927
63FGFR30.83227519
64EEF2K0.81048872
65HCK0.78057365
66ARAF0.77994448
67IRAK40.76837153
68OXSR10.75281275
69DYRK1B0.74671843
70IKBKE0.73901716
71CDK70.72404434
72MAPK120.71569342
73RPS6KC10.69691594
74RPS6KL10.69691594
75PDPK10.69476514
76RPS6KA20.69456907
77MAP3K70.68595153
78ADRBK10.68186489
79FGR0.64431635
80LCK0.61462091
81MAP3K140.61306495
82PKN10.59801600
83PRKD30.57141794
84PRPF4B0.56804442
85MET0.56467915
86LRRK20.55807395
87MAPK110.55781318
88BMX0.55432211
89PIM20.54086107
90PRKCD0.53752777
91PDGFRA0.52376662
92MAPKAPK50.51640631
93STK380.51253868
94CAMKK10.50911949
95ERBB20.49182900
96RPS6KA60.48589392
97BTK0.47516170
98CDK40.47213223
99EPHA20.46632743
100IGF1R0.46346498
101STK40.46178215
102MAP2K60.46024093
103PAK10.45609093
104DDR20.45190460
105RET0.44882265
106IRAK20.43789260
107SYK0.43249394
108MAPKAPK20.43065729
109MAPKAPK30.39667224
110INSR0.39097067
111MAP3K80.39064169
112GSK3A0.37559333
113PRKCQ0.37412977
114TRPM70.37033760
115LYN0.36966545
116TXK0.35386539
117ICK0.34231407
118EIF2AK20.33632373
119CHUK0.32299328
120CAMK1D0.32194208
121KDR0.32076366
122ABL10.31713787
123MAP2K20.31688669
124EGFR0.30774990
125MAP3K130.29431971
126PRKCH0.29381252
127IRAK30.28049197
128FGFR40.27184534
129PTK20.27090123
130LIMK10.27053824
131ALK0.27037904
132JAK10.26836200
133PRKD10.26630506
134PDK10.25497013
135FYN0.25259778
136JAK20.25192576
137MAPK40.25153331
138JAK30.25126723
139CDK190.24622657
140MARK30.23722930
141PRKD20.22346341
142AKT30.21947972
143MTOR0.21513423
144SRC0.21174709

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.18923936
2Vitamin B6 metabolism_Homo sapiens_hsa007504.69758906
3Other glycan degradation_Homo sapiens_hsa005112.71291515
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.49833391
5Fructose and mannose metabolism_Homo sapiens_hsa000512.35065125
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.34481927
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.31826595
8Staphylococcus aureus infection_Homo sapiens_hsa051502.23418984
9Lysosome_Homo sapiens_hsa041422.23414182
10Arachidonic acid metabolism_Homo sapiens_hsa005902.20703516
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14375086
12Leishmaniasis_Homo sapiens_hsa051402.13322307
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81234117
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.75241460
15Pertussis_Homo sapiens_hsa051331.67981141
16Malaria_Homo sapiens_hsa051441.62820249
17Galactose metabolism_Homo sapiens_hsa000521.61505654
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.61368111
19Linoleic acid metabolism_Homo sapiens_hsa005911.60959008
20Ether lipid metabolism_Homo sapiens_hsa005651.59822630
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56945325
22Non-small cell lung cancer_Homo sapiens_hsa052231.52297246
23Chronic myeloid leukemia_Homo sapiens_hsa052201.43761789
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43237221
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42947038
26Bladder cancer_Homo sapiens_hsa052191.42131671
27Legionellosis_Homo sapiens_hsa051341.38333849
28Allograft rejection_Homo sapiens_hsa053301.37478766
29African trypanosomiasis_Homo sapiens_hsa051431.35719821
30Steroid biosynthesis_Homo sapiens_hsa001001.34281293
31B cell receptor signaling pathway_Homo sapiens_hsa046621.32836765
32Primary immunodeficiency_Homo sapiens_hsa053401.31936315
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.31318038
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30646246
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26290365
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.24687977
37Tuberculosis_Homo sapiens_hsa051521.20231807
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19563755
39Fatty acid elongation_Homo sapiens_hsa000621.17864278
40Endometrial cancer_Homo sapiens_hsa052131.13824545
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12596621
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10766903
43Herpes simplex infection_Homo sapiens_hsa051681.09791121
44Hematopoietic cell lineage_Homo sapiens_hsa046401.09578747
45Osteoclast differentiation_Homo sapiens_hsa043801.09177703
46Influenza A_Homo sapiens_hsa051641.08848564
47Intestinal immune network for IgA production_Homo sapiens_hsa046721.06510643
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05138880
49Apoptosis_Homo sapiens_hsa042101.03415386
50Hepatitis B_Homo sapiens_hsa051611.02968589
51Toxoplasmosis_Homo sapiens_hsa051451.02770637
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01045287
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.98906378
54Measles_Homo sapiens_hsa051620.95247364
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.95161603
56Graft-versus-host disease_Homo sapiens_hsa053320.92560115
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90122354
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.90036155
59Prolactin signaling pathway_Homo sapiens_hsa049170.89785101
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89276037
61Shigellosis_Homo sapiens_hsa051310.86320059
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86292991
63Platelet activation_Homo sapiens_hsa046110.85873154
64Phagosome_Homo sapiens_hsa041450.85202037
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.83732254
66Rheumatoid arthritis_Homo sapiens_hsa053230.82729075
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.82014345
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81889010
69Complement and coagulation cascades_Homo sapiens_hsa046100.81802334
70Acute myeloid leukemia_Homo sapiens_hsa052210.81010696
71Amoebiasis_Homo sapiens_hsa051460.79609566
72GnRH signaling pathway_Homo sapiens_hsa049120.78585645
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.78528812
74Antigen processing and presentation_Homo sapiens_hsa046120.77811352
75ErbB signaling pathway_Homo sapiens_hsa040120.77560547
76Vibrio cholerae infection_Homo sapiens_hsa051100.77091373
77T cell receptor signaling pathway_Homo sapiens_hsa046600.76228990
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74015205
79Hepatitis C_Homo sapiens_hsa051600.73994873
80Salmonella infection_Homo sapiens_hsa051320.73015422
81Type I diabetes mellitus_Homo sapiens_hsa049400.72709907
82Sphingolipid metabolism_Homo sapiens_hsa006000.71643230
83Insulin signaling pathway_Homo sapiens_hsa049100.69865688
84Pentose phosphate pathway_Homo sapiens_hsa000300.69551257
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68219181
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67452871
87Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67263743
88Renal cell carcinoma_Homo sapiens_hsa052110.67189957
89Viral carcinogenesis_Homo sapiens_hsa052030.66686311
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66271457
91HIF-1 signaling pathway_Homo sapiens_hsa040660.66260618
92HTLV-I infection_Homo sapiens_hsa051660.64444673
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64301105
94Chemokine signaling pathway_Homo sapiens_hsa040620.64058082
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.64040825
96Prion diseases_Homo sapiens_hsa050200.63102253
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62945424
98Sulfur relay system_Homo sapiens_hsa041220.62596524
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62460937
100Notch signaling pathway_Homo sapiens_hsa043300.61825074
101Epstein-Barr virus infection_Homo sapiens_hsa051690.60850165
102Insulin resistance_Homo sapiens_hsa049310.60581058
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60295265
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.59123403
105Endocytosis_Homo sapiens_hsa041440.58298888
106Renin-angiotensin system_Homo sapiens_hsa046140.58150573
107Estrogen signaling pathway_Homo sapiens_hsa049150.57761938
108Inositol phosphate metabolism_Homo sapiens_hsa005620.57334874
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57076953
110Thyroid cancer_Homo sapiens_hsa052160.55696016
111Chemical carcinogenesis_Homo sapiens_hsa052040.54740508
112Folate biosynthesis_Homo sapiens_hsa007900.54672026
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54446829
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54365882
115Prostate cancer_Homo sapiens_hsa052150.53873529
116Pancreatic cancer_Homo sapiens_hsa052120.52844966
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51293727
118Viral myocarditis_Homo sapiens_hsa054160.50741504
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.49776431
120Glioma_Homo sapiens_hsa052140.49543152
121Rap1 signaling pathway_Homo sapiens_hsa040150.49434181
122Colorectal cancer_Homo sapiens_hsa052100.48930981
123Autoimmune thyroid disease_Homo sapiens_hsa053200.48293365
124Asthma_Homo sapiens_hsa053100.48174259
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47630382
126TNF signaling pathway_Homo sapiens_hsa046680.44036112
127Pathways in cancer_Homo sapiens_hsa052000.40963142
128VEGF signaling pathway_Homo sapiens_hsa043700.40278077
129Glutathione metabolism_Homo sapiens_hsa004800.34571718
130Histidine metabolism_Homo sapiens_hsa003400.31204180
131ABC transporters_Homo sapiens_hsa020100.29356309
132mTOR signaling pathway_Homo sapiens_hsa041500.27145285
133Choline metabolism in cancer_Homo sapiens_hsa052310.26508891
134Proteoglycans in cancer_Homo sapiens_hsa052050.25467169
135Regulation of autophagy_Homo sapiens_hsa041400.25415735
136Vitamin digestion and absorption_Homo sapiens_hsa049770.23491376

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