STARD3NL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a late-endosomal protein that contains a conserved MENTAL (MLN64 N-terminal) domain. The encoded protein binds cholesterol molecules and may play a role in endosomal cholesterol transport through interactions with metastatic lymph node protein 64 (MLN64). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.28759727
2platelet dense granule organization (GO:0060155)4.93554781
3pyrimidine nucleobase catabolic process (GO:0006208)4.89027938
4chaperone-mediated protein transport (GO:0072321)4.07984679
5nucleobase catabolic process (GO:0046113)3.83264077
6positive regulation of actin filament depolymerization (GO:0030836)3.81951047
7DNA double-strand break processing (GO:0000729)3.74112944
8organelle disassembly (GO:1903008)3.66860871
9central nervous system myelination (GO:0022010)3.65999463
10axon ensheathment in central nervous system (GO:0032291)3.65999463
11proteasome assembly (GO:0043248)3.65557034
12regulation of cilium movement (GO:0003352)3.63971356
13nonmotile primary cilium assembly (GO:0035058)3.55351983
14protein deneddylation (GO:0000338)3.51650941
15ribonucleoprotein complex disassembly (GO:0032988)3.42110928
16DNA damage response, detection of DNA damage (GO:0042769)3.33092292
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.32982735
18intraciliary transport (GO:0042073)3.26041400
19positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.21769080
20cullin deneddylation (GO:0010388)3.21371833
21protein complex biogenesis (GO:0070271)3.20017298
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18670552
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18670552
24fatty acid elongation (GO:0030497)3.09366040
25respiratory chain complex IV assembly (GO:0008535)3.09031168
26phagosome maturation (GO:0090382)3.08158795
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06899491
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.06899491
29NADH dehydrogenase complex assembly (GO:0010257)3.06899491
30anterograde synaptic vesicle transport (GO:0048490)3.06401131
31regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.05789480
32mitochondrial respiratory chain complex assembly (GO:0033108)3.02015045
33protein K11-linked ubiquitination (GO:0070979)3.01909574
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99852665
35neural tube formation (GO:0001841)2.97567305
36neutrophil activation involved in immune response (GO:0002283)2.97020501
37deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.96112775
38transcription elongation from RNA polymerase III promoter (GO:0006385)2.92678418
39termination of RNA polymerase III transcription (GO:0006386)2.92678418
40response to pheromone (GO:0019236)2.88704354
41neurofilament cytoskeleton organization (GO:0060052)2.88321382
42histone H2A acetylation (GO:0043968)2.87603696
43C-terminal protein amino acid modification (GO:0018410)2.85547144
44cilium morphogenesis (GO:0060271)2.84449423
45anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84221212
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.83424316
47transferrin transport (GO:0033572)2.82674319
48C-terminal protein lipidation (GO:0006501)2.80375770
49neuron cell-cell adhesion (GO:0007158)2.79378827
50sequestering of actin monomers (GO:0042989)2.77831036
51anterograde axon cargo transport (GO:0008089)2.77330150
52regulation of mitochondrial fission (GO:0090140)2.76552409
53peptidyl-histidine modification (GO:0018202)2.76530527
54mannosylation (GO:0097502)2.76081241
55metallo-sulfur cluster assembly (GO:0031163)2.75622508
56iron-sulfur cluster assembly (GO:0016226)2.75622508
57adenosine metabolic process (GO:0046085)2.75342734
58GPI anchor metabolic process (GO:0006505)2.74776462
59negative regulation of membrane potential (GO:0045837)2.72973004
60negative regulation of neurotransmitter transport (GO:0051589)2.72153683
61positive regulation of mitochondrial fission (GO:0090141)2.71809652
62regulation of histone phosphorylation (GO:0033127)2.71661255
63response to redox state (GO:0051775)2.70531205
64protein-cofactor linkage (GO:0018065)2.70312790
65peripheral nervous system neuron development (GO:0048935)2.70085204
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68901862
67L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68209778
68behavioral response to nicotine (GO:0035095)2.67738257
692-deoxyribonucleotide biosynthetic process (GO:0009265)2.66389777
70deoxyribose phosphate biosynthetic process (GO:0046385)2.66389777
71glycosphingolipid biosynthetic process (GO:0006688)2.66240349
72negative regulation of neurotransmitter secretion (GO:0046929)2.65921375
73signal transduction involved in cell cycle checkpoint (GO:0072395)2.65835087
74ubiquinone metabolic process (GO:0006743)2.64952506
75water-soluble vitamin biosynthetic process (GO:0042364)2.62168558
76pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.60829826
77retinal ganglion cell axon guidance (GO:0031290)2.60370695
787-methylguanosine mRNA capping (GO:0006370)2.60056511
79substantia nigra development (GO:0021762)2.59829313
80preassembly of GPI anchor in ER membrane (GO:0016254)2.59606357
81long-chain fatty acid biosynthetic process (GO:0042759)2.59421316
82signal transduction involved in DNA damage checkpoint (GO:0072422)2.58737671
83signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58737671
84maturation of 5.8S rRNA (GO:0000460)2.58205635
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.57742698
86RNA capping (GO:0036260)2.56854188
877-methylguanosine RNA capping (GO:0009452)2.56854188
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56789309
89lactate metabolic process (GO:0006089)2.56753946
90epithelial cilium movement (GO:0003351)2.56660240
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55988362
92regulation of mitotic spindle checkpoint (GO:1903504)2.55988362
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55456844
94establishment of mitochondrion localization (GO:0051654)2.55361429
95regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54242851
96positive regulation of ligase activity (GO:0051351)2.53796538
97cilium assembly (GO:0042384)2.52848370
98cilium organization (GO:0044782)2.52712503
99base-excision repair, AP site formation (GO:0006285)2.50757507
100regulation of cell maturation (GO:1903429)2.50649667
101cytochrome complex assembly (GO:0017004)2.50035995
102trivalent inorganic cation transport (GO:0072512)2.49426358
103ferric iron transport (GO:0015682)2.49426358
104ubiquinone biosynthetic process (GO:0006744)2.49424920
105ATP hydrolysis coupled proton transport (GO:0015991)2.49094930
106energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.49094930
107establishment of viral latency (GO:0019043)2.48472201
108rhodopsin mediated signaling pathway (GO:0016056)2.48336098
109establishment of melanosome localization (GO:0032401)2.46559412
110respiratory electron transport chain (GO:0022904)2.45715480
111detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.44616928
112detection of temperature stimulus involved in sensory perception (GO:0050961)2.44616928
113regulation of heat generation (GO:0031650)2.44136536
114establishment of integrated proviral latency (GO:0075713)2.44020925
115presynaptic membrane organization (GO:0097090)2.43806757
116eosinophil chemotaxis (GO:0048245)2.43673059
117electron transport chain (GO:0022900)2.42663408
118olfactory bulb development (GO:0021772)2.42418850
119negative regulation of ligase activity (GO:0051352)2.42036352
120negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.42036352
121de novo posttranslational protein folding (GO:0051084)2.41537349
122glycerophospholipid catabolic process (GO:0046475)2.40728166
123negative regulation of microtubule polymerization (GO:0031115)2.40386255
124presynaptic membrane assembly (GO:0097105)2.40256923
125de novo protein folding (GO:0006458)2.39818931
126DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38720174
127mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.34987528
128establishment of pigment granule localization (GO:0051905)2.34159870
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.32891765
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.32891765
131regulation of collateral sprouting (GO:0048670)2.32021490
132positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.31992523
133enteric nervous system development (GO:0048484)2.31747596
134regulation of cellular amino acid metabolic process (GO:0006521)2.31017428
135isoprenoid biosynthetic process (GO:0008299)2.30673359
136signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.30567564
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.30567564
138signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.30567564
139mitochondrion morphogenesis (GO:0070584)2.30274493
140ATP synthesis coupled proton transport (GO:0015986)2.30240900
141energy coupled proton transport, down electrochemical gradient (GO:0015985)2.30240900
142cellular response to superoxide (GO:0071451)2.29951722
143cellular response to oxygen radical (GO:0071450)2.29951722
144removal of superoxide radicals (GO:0019430)2.29951722
145antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.28573901
146antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.28279216
147microtubule polymerization or depolymerization (GO:0031109)2.28093791
148intracellular pH reduction (GO:0051452)2.27904542
149regulation of mitochondrial translation (GO:0070129)2.27004499
150response to misfolded protein (GO:0051788)2.26245816
151detection of temperature stimulus (GO:0016048)2.25284915
152protein localization to cilium (GO:0061512)2.25222765
153melanosome transport (GO:0032402)2.24555683
154dendrite development (GO:0016358)2.23797410
155negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.23674622
156regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.23309366
157regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.23082660
158regulation of catecholamine metabolic process (GO:0042069)2.22969187
159regulation of dopamine metabolic process (GO:0042053)2.22969187
160positive regulation of TOR signaling (GO:0032008)2.21545878
161viral protein processing (GO:0019082)2.20914259
162negative regulation of calcium ion transport into cytosol (GO:0010523)2.20094523
163positive regulation of monocyte chemotaxis (GO:0090026)2.19377700
164microglial cell activation (GO:0001774)2.19288986
165positive regulation of type 2 immune response (GO:0002830)2.19265414
166positive regulation of protein depolymerization (GO:1901881)2.19141647
167cholesterol biosynthetic process (GO:0006695)2.17766441

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.31428672
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.17732859
3ZNF274_21170338_ChIP-Seq_K562_Hela3.00218239
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.91414452
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76471406
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60187506
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.58351573
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39667911
9* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37668399
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37088289
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32356229
12TAF15_26573619_Chip-Seq_HEK293_Human2.25017544
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24289111
14GBX2_23144817_ChIP-Seq_PC3_Human2.15344908
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04186433
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02480194
17VDR_23849224_ChIP-Seq_CD4+_Human2.01293241
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98045303
19EST1_17652178_ChIP-ChIP_JURKAT_Human1.93936629
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92722386
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92269482
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87752601
23* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85413922
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84650358
25IGF1R_20145208_ChIP-Seq_DFB_Human1.84183299
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.80287730
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77415184
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73353549
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.72728319
30RNF2_27304074_Chip-Seq_NSC_Mouse1.69002064
31FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.66000331
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61517524
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.61141918
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.59586877
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57629898
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56859035
37* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53711334
38MYC_18940864_ChIP-ChIP_HL60_Human1.51413273
39P300_19829295_ChIP-Seq_ESCs_Human1.48547899
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47021868
41EZH2_22144423_ChIP-Seq_EOC_Human1.46635912
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.44821545
43ELK1_19687146_ChIP-ChIP_HELA_Human1.44468180
44* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41964053
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38382336
46CBP_20019798_ChIP-Seq_JUKART_Human1.38382336
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35052973
48FOXP3_21729870_ChIP-Seq_TREG_Human1.34781195
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33161437
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31708719
51IRF1_19129219_ChIP-ChIP_H3396_Human1.28869536
52CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.26168272
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25933830
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25933830
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25933830
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.25714698
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25574259
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24634997
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22805381
60JUN_21703547_ChIP-Seq_K562_Human1.22733814
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.22447826
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20948707
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20207807
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.19932604
65* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19654652
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19346865
67FUS_26573619_Chip-Seq_HEK293_Human1.17699807
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.17575429
69EWS_26573619_Chip-Seq_HEK293_Human1.16915333
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.16533350
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.16486497
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16091540
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16024458
74ELK1_22589737_ChIP-Seq_MCF10A_Human1.15964452
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15422605
76* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14491487
77MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14384048
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12758922
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.12618093
80* TAL1_26923725_Chip-Seq_HPCs_Mouse1.12052951
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11561103
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11514733
83* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11387598
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.11137173
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10461257
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09995873
87ER_23166858_ChIP-Seq_MCF-7_Human1.09838850
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09427450
89* AR_25329375_ChIP-Seq_VCAP_Human1.09316211
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08867808
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08352080
92GABP_19822575_ChIP-Seq_HepG2_Human1.07577665
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07528992
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06810130
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06543366
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06424588
97* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06273863
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.04620444
99HTT_18923047_ChIP-ChIP_STHdh_Human1.04125052
100SOX2_16153702_ChIP-ChIP_HESCs_Human1.03647847
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.03536385
102DCP1A_22483619_ChIP-Seq_HELA_Human1.02205743
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02010680
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.00874940
105REST_21632747_ChIP-Seq_MESCs_Mouse1.00060071
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99710724
107WT1_19549856_ChIP-ChIP_CCG9911_Human0.99002345
108EZH2_27304074_Chip-Seq_ESCs_Mouse0.98558327
109NFE2_27457419_Chip-Seq_LIVER_Mouse0.98379173
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98310954
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98310954
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98038486
113SOX2_19829295_ChIP-Seq_ESCs_Human0.97505869
114NANOG_19829295_ChIP-Seq_ESCs_Human0.97505869
115YY1_21170310_ChIP-Seq_MESCs_Mouse0.95797189
116P53_22387025_ChIP-Seq_ESCs_Mouse0.95175080
117SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95031831
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94787237
119BCAT_22108803_ChIP-Seq_LS180_Human0.94771745
120TCF4_22108803_ChIP-Seq_LS180_Human0.94703726
121SALL4_22934838_ChIP-ChIP_CD34+_Human0.94519592
122E2F1_18555785_Chip-Seq_ESCs_Mouse0.94493663
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.94042181
124IRF8_22096565_ChIP-ChIP_GC-B_Human0.93876804
125EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93852733
126SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.93500752
127* PRDM14_20953172_ChIP-Seq_ESCs_Human0.93407353
128STAT3_23295773_ChIP-Seq_U87_Human0.92872260
129* RUNX2_22187159_ChIP-Seq_PCA_Human0.92767937
130* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.90992413
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90964720
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90921868
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90821844
134SMAD4_21799915_ChIP-Seq_A2780_Human0.90236303
135TP53_22573176_ChIP-Seq_HFKS_Human0.90031497
136NMYC_18555785_Chip-Seq_ESCs_Mouse0.89731519
137SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88870043
138REST_18959480_ChIP-ChIP_MESCs_Mouse0.88780103
139FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88592885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity3.83071309
2MP0002102_abnormal_ear_morphology3.65240326
3MP0001529_abnormal_vocalization3.61033188
4MP0003880_abnormal_central_pattern3.33244805
5MP0006276_abnormal_autonomic_nervous2.93018315
6MP0002735_abnormal_chemical_nociception2.90153659
7MP0005171_absent_coat_pigmentation2.83812770
8MP0001968_abnormal_touch/_nociception2.75236044
9MP0001905_abnormal_dopamine_level2.74032772
10MP0004270_analgesia2.67167312
11MP0005423_abnormal_somatic_nervous2.62662190
12MP0002736_abnormal_nociception_after2.62468174
13MP0002734_abnormal_mechanical_nocicepti2.56603471
14MP0006054_spinal_hemorrhage2.30771873
15MP0008058_abnormal_DNA_repair2.14634454
16MP0003136_yellow_coat_color2.08395848
17MP0001970_abnormal_pain_threshold2.06741431
18MP0000920_abnormal_myelination2.01097205
19MP0003195_calcinosis2.01023209
20MP0002733_abnormal_thermal_nociception1.96684371
21MP0001984_abnormal_olfaction1.95728545
22MP0005084_abnormal_gallbladder_morpholo1.89575678
23MP0000372_irregular_coat_pigmentation1.89016790
24MP0006082_CNS_inflammation1.88756909
25MP0002272_abnormal_nervous_system1.88071990
26MP0000778_abnormal_nervous_system1.87425728
27MP0002638_abnormal_pupillary_reflex1.81922186
28MP0002090_abnormal_vision1.80760374
29MP0008260_abnormal_autophagy1.77772088
30MP0010386_abnormal_urinary_bladder1.72817396
31MP0002822_catalepsy1.71558828
32MP0001188_hyperpigmentation1.70775958
33MP0006292_abnormal_olfactory_placode1.70453232
34MP0004142_abnormal_muscle_tone1.69444762
35MP0003011_delayed_dark_adaptation1.66566597
36MP0005058_abnormal_lysosome_morphology1.57305902
37MP0000516_abnormal_urinary_system1.56898046
38MP0005367_renal/urinary_system_phenotyp1.56898046
39MP0002277_abnormal_respiratory_mucosa1.55714191
40MP0002064_seizures1.53428683
41MP0002148_abnormal_hypersensitivity_rea1.51289228
42MP0003634_abnormal_glial_cell1.42766532
43MP0002751_abnormal_autonomic_nervous1.42643883
44MP0004859_abnormal_synaptic_plasticity1.41565711
45MP0002184_abnormal_innervation1.40224061
46MP0004147_increased_porphyrin_level1.40035774
47MP0003950_abnormal_plasma_membrane1.37587434
48MP0004133_heterotaxia1.36147728
49MP0005167_abnormal_blood-brain_barrier1.35200369
50MP0003890_abnormal_embryonic-extraembry1.35189727
51MP0004858_abnormal_nervous_system1.34391099
52MP0005408_hypopigmentation1.33780548
53MP0002653_abnormal_ependyma_morphology1.33488633
54MP0002572_abnormal_emotion/affect_behav1.31748644
55MP0004782_abnormal_surfactant_physiolog1.31622840
56MP0006035_abnormal_mitochondrial_morpho1.31485177
57MP0002067_abnormal_sensory_capabilities1.30873978
58MP0009745_abnormal_behavioral_response1.25298549
59MP0002163_abnormal_gland_morphology1.24812215
60MP0000647_abnormal_sebaceous_gland1.24753601
61MP0003635_abnormal_synaptic_transmissio1.24208229
62MP0009046_muscle_twitch1.23715810
63MP0009785_altered_susceptibility_to1.23309107
64MP0002063_abnormal_learning/memory/cond1.23189865
65MP0003221_abnormal_cardiomyocyte_apopto1.22805474
66MP0004924_abnormal_behavior1.20991436
67MP0005386_behavior/neurological_phenoty1.20991436
68MP0001486_abnormal_startle_reflex1.18840483
69MP0002234_abnormal_pharynx_morphology1.17556079
70MP0008789_abnormal_olfactory_epithelium1.17308860
71MP0001293_anophthalmia1.17214127
72MP0001440_abnormal_grooming_behavior1.16546076
73MP0001835_abnormal_antigen_presentation1.16457898
74MP0003122_maternal_imprinting1.15477888
75MP0001324_abnormal_eye_pigmentation1.14305600
76MP0001542_abnormal_bone_strength1.12169834
77MP0005645_abnormal_hypothalamus_physiol1.12031790
78MP0000955_abnormal_spinal_cord1.11878849
79MP0000015_abnormal_ear_pigmentation1.10293591
80MP0002882_abnormal_neuron_morphology1.09095329
81MP0002233_abnormal_nose_morphology1.09041689
82MP0005499_abnormal_olfactory_system1.08613352
83MP0005394_taste/olfaction_phenotype1.08613352
84MP0000358_abnormal_cell_content/1.06434345
85MP0002837_dystrophic_cardiac_calcinosis1.05153306
86MP0005195_abnormal_posterior_eye1.01812237
87MP0005409_darkened_coat_color1.01116934
88MP0008877_abnormal_DNA_methylation1.00966426
89MP0008932_abnormal_embryonic_tissue1.00808794
90MP0003690_abnormal_glial_cell0.99315570
91MP0002752_abnormal_somatic_nervous0.99135289
92MP0002229_neurodegeneration0.98978283
93MP0009697_abnormal_copulation0.97553097
94MP0004742_abnormal_vestibular_system0.97452117
95MP0004215_abnormal_myocardial_fiber0.97407320
96MP0010094_abnormal_chromosome_stability0.97356936
97MP0002557_abnormal_social/conspecific_i0.97158264
98MP0000569_abnormal_digit_pigmentation0.96955062
99MP0001963_abnormal_hearing_physiology0.95611715
100MP0008007_abnormal_cellular_replicative0.94967840
101MP0006036_abnormal_mitochondrial_physio0.94875397
102MP0005391_vision/eye_phenotype0.94656161
103MP0005410_abnormal_fertilization0.92936066
104MP0004811_abnormal_neuron_physiology0.92575770
105MP0002938_white_spotting0.92426170
106MP0003718_maternal_effect0.91687779
107MP0001346_abnormal_lacrimal_gland0.90360169
108MP0001501_abnormal_sleep_pattern0.90262861
109MP0003329_amyloid_beta_deposits0.89392333
110MP0005310_abnormal_salivary_gland0.86363904
111MP0005646_abnormal_pituitary_gland0.86208829
112MP0001764_abnormal_homeostasis0.86063912
113MP0003121_genomic_imprinting0.82367441
114MP0005248_abnormal_Harderian_gland0.82098486
115MP0000049_abnormal_middle_ear0.80632084
116MP0009764_decreased_sensitivity_to0.80487396
117MP0003632_abnormal_nervous_system0.80334337
118MP0003787_abnormal_imprinting0.79646739
119MP0006072_abnormal_retinal_apoptosis0.79435398
120MP0002066_abnormal_motor_capabilities/c0.78688079
121MP0001485_abnormal_pinna_reflex0.78598949
122MP0002095_abnormal_skin_pigmentation0.78263190
123MP0005671_abnormal_response_to0.78217135
124MP0003693_abnormal_embryo_hatching0.77999980
125MP0005000_abnormal_immune_tolerance0.77784105
126MP0004883_abnormal_blood_vessel0.77223439
127MP0002069_abnormal_eating/drinking_beha0.76556440
128MP0005253_abnormal_eye_physiology0.76329942
129MP0000026_abnormal_inner_ear0.76061437
130MP0005551_abnormal_eye_electrophysiolog0.76061228
131MP0003631_nervous_system_phenotype0.73551656
132MP0002295_abnormal_pulmonary_circulatio0.73314114
133MP0003123_paternal_imprinting0.71999348
134MP0003186_abnormal_redox_activity0.70429387
135MP0000631_abnormal_neuroendocrine_gland0.69967965
136MP0000681_abnormal_thyroid_gland0.67299589
137MP0000858_altered_metastatic_potential0.64195704
138MP0002419_abnormal_innate_immunity0.64081351
139MP0005164_abnormal_response_to0.62341801

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)4.07841673
2Cerebral hypomyelination (HP:0006808)4.04147867
3Cortical dysplasia (HP:0002539)3.44807461
4Abnormal hair whorl (HP:0010721)3.38998535
5Myokymia (HP:0002411)3.32380435
6Acute necrotizing encephalopathy (HP:0006965)3.31260187
7True hermaphroditism (HP:0010459)3.28984532
8Pancreatic cysts (HP:0001737)3.19048903
9Molar tooth sign on MRI (HP:0002419)3.09061267
10Abnormality of midbrain morphology (HP:0002418)3.09061267
11Methylmalonic acidemia (HP:0002912)3.05172615
12Adrenal hypoplasia (HP:0000835)3.02774969
13Medial flaring of the eyebrow (HP:0010747)2.96086975
14Gait imbalance (HP:0002141)2.92439451
15Lipid accumulation in hepatocytes (HP:0006561)2.91118911
16Abnormal mitochondria in muscle tissue (HP:0008316)2.86600479
17Limb dystonia (HP:0002451)2.81933419
18Abnormality of the labia minora (HP:0012880)2.79889824
19Genital tract atresia (HP:0001827)2.79857087
203-Methylglutaconic aciduria (HP:0003535)2.78913928
21Abnormality of liposaccharide metabolism (HP:0010968)2.75533054
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.75533054
23Abnormality of glycolipid metabolism (HP:0010969)2.75533054
24Leukodystrophy (HP:0002415)2.74825260
25Vaginal atresia (HP:0000148)2.71157607
26Congenital primary aphakia (HP:0007707)2.67906467
27Parakeratosis (HP:0001036)2.65064274
28Progressive macrocephaly (HP:0004481)2.64318836
29CNS hypomyelination (HP:0003429)2.63354342
30Neurofibrillary tangles (HP:0002185)2.60886393
31Hepatic necrosis (HP:0002605)2.58702582
32Nephrogenic diabetes insipidus (HP:0009806)2.58609611
33Mitochondrial inheritance (HP:0001427)2.58037080
34Patchy hypopigmentation of hair (HP:0011365)2.50563570
35Methylmalonic aciduria (HP:0012120)2.47356804
36Segmental peripheral demyelination/remyelination (HP:0003481)2.47221274
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46585009
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.46585009
39Prolonged neonatal jaundice (HP:0006579)2.45237909
40Peripheral hypomyelination (HP:0007182)2.45229049
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.44959200
42Nephronophthisis (HP:0000090)2.44812568
43Autoamputation (HP:0001218)2.44670596
44Hyperglycinemia (HP:0002154)2.43034568
45Lissencephaly (HP:0001339)2.42895699
46White forelock (HP:0002211)2.41533455
47Ulnar claw (HP:0001178)2.36028257
48Supranuclear gaze palsy (HP:0000605)2.35646181
49Split foot (HP:0001839)2.35637345
50Atrophy/Degeneration involving motor neurons (HP:0007373)2.30274787
51Prostate neoplasm (HP:0100787)2.29420881
52Type I transferrin isoform profile (HP:0003642)2.29124137
53Neuroendocrine neoplasm (HP:0100634)2.27625240
54Recurrent abscess formation (HP:0002722)2.26120623
55Hepatocellular necrosis (HP:0001404)2.24941950
56Hyperalaninemia (HP:0003348)2.22022995
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22022995
58Abnormality of alanine metabolism (HP:0010916)2.22022995
59Renal cortical cysts (HP:0000803)2.21588189
60Retinal dysplasia (HP:0007973)2.21149117
61Acute encephalopathy (HP:0006846)2.21069536
62Increased CSF lactate (HP:0002490)2.20272919
63Pheochromocytoma (HP:0002666)2.20117413
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.19883936
65Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17388921
66Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17388921
67Amyotrophic lateral sclerosis (HP:0007354)2.15588162
68Lactic acidosis (HP:0003128)2.15279656
69Postaxial hand polydactyly (HP:0001162)2.14946443
70Abolished electroretinogram (ERG) (HP:0000550)2.14614864
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13085411
72Abnormal protein N-linked glycosylation (HP:0012347)2.13085411
73Abnormal protein glycosylation (HP:0012346)2.13085411
74Abnormal glycosylation (HP:0012345)2.13085411
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.11179976
76Short tibia (HP:0005736)2.11141742
77Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11070817
78Aplasia/Hypoplasia of the tibia (HP:0005772)2.10630899
79Abnormal autonomic nervous system physiology (HP:0012332)2.09847593
80Metaphyseal dysplasia (HP:0100255)2.09549063
81Increased serum lactate (HP:0002151)2.08269158
82Anencephaly (HP:0002323)2.07459308
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.07298386
84Sclerocornea (HP:0000647)2.05519609
85Bifid tongue (HP:0010297)2.05059075
86Increased serum pyruvate (HP:0003542)2.03257254
87Abnormality of glycolysis (HP:0004366)2.03257254
88Increased intramyocellular lipid droplets (HP:0012240)2.03211441
89Heterochromia iridis (HP:0001100)2.02850834
90Abnormality of the renal medulla (HP:0100957)2.01929657
91Hepatosplenomegaly (HP:0001433)2.00648145
92Decreased testicular size (HP:0008734)1.99593894
93Poor coordination (HP:0002370)1.98775478
94Abnormal biliary tract physiology (HP:0012439)1.98245496
95Bile duct proliferation (HP:0001408)1.98245496
96Cerebral edema (HP:0002181)1.98237961
97Specific learning disability (HP:0001328)1.98234666
98Colon cancer (HP:0003003)1.96913988
99Polyphagia (HP:0002591)1.96282621
100Abnormality of the corticospinal tract (HP:0002492)1.95878843
101Pachygyria (HP:0001302)1.94138548
102Atonic seizures (HP:0010819)1.94004164
103Abnormality of the septum pellucidum (HP:0007375)1.93315747
104Fibular aplasia (HP:0002990)1.93214127
105Abnormality of the anterior horn cell (HP:0006802)1.92772538
106Degeneration of anterior horn cells (HP:0002398)1.92772538
107Absent septum pellucidum (HP:0001331)1.92281157
108Abnormality of macrophages (HP:0004311)1.91498322
109Abnormality of macular pigmentation (HP:0008002)1.88730900
110Generalized aminoaciduria (HP:0002909)1.88367761
111Abnormality of the renal cortex (HP:0011035)1.88198211
112Renal Fanconi syndrome (HP:0001994)1.87583328
113Akinesia (HP:0002304)1.86635271
114Occipital encephalocele (HP:0002085)1.85954441
115Postaxial foot polydactyly (HP:0001830)1.84848762
116Postnatal microcephaly (HP:0005484)1.84386216
117Progressive inability to walk (HP:0002505)1.84320723
118Rectovaginal fistula (HP:0000143)1.84030106
119Rectal fistula (HP:0100590)1.84030106
120Eczematoid dermatitis (HP:0000976)1.83688495
121Optic disc pallor (HP:0000543)1.81184275
122Type II lissencephaly (HP:0007260)1.80975300
123Adactyly (HP:0009776)1.80946176
124Increased hepatocellular lipid droplets (HP:0006565)1.80892962
125Sensory axonal neuropathy (HP:0003390)1.80744296
126Abnormality of renal resorption (HP:0011038)1.80535116
127Narrow forehead (HP:0000341)1.79943959
128Upper limb muscle weakness (HP:0003484)1.77321303
129Ankle clonus (HP:0011448)1.77285443
130Chronic hepatic failure (HP:0100626)1.76981128
131Septo-optic dysplasia (HP:0100842)1.76838902
132Intestinal atresia (HP:0011100)1.76314638
133Supernumerary spleens (HP:0009799)1.75300324
134Respiratory failure (HP:0002878)1.75212667
135Abnormality of serum amino acid levels (HP:0003112)1.75095975
136Xerostomia (HP:0000217)1.75059552
137Inability to walk (HP:0002540)1.74935683
138Drooling (HP:0002307)1.74814896
139Increased cerebral lipofuscin (HP:0011813)1.74496385
140Failure to thrive in infancy (HP:0001531)1.74303581
141Oligodactyly (hands) (HP:0001180)1.72018594
142Mutism (HP:0002300)1.71961684
143Aplasia/Hypoplasia of the lens (HP:0008063)1.71111541
144Progressive neurologic deterioration (HP:0002344)1.71038323
145Pancreatic fibrosis (HP:0100732)1.70824626
146Poor head control (HP:0002421)1.69688909
147Congenital ichthyosiform erythroderma (HP:0007431)1.69570750
148CNS demyelination (HP:0007305)1.69425121
149Esotropia (HP:0000565)1.69176704
150Aganglionic megacolon (HP:0002251)1.68348967
151Sleep apnea (HP:0010535)1.68328949
152Recurrent bacterial skin infections (HP:0005406)1.68262205
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.67456678
154Congenital hepatic fibrosis (HP:0002612)1.67311020
155Oculomotor apraxia (HP:0000657)1.66520763
156Exertional dyspnea (HP:0002875)1.65546557
157Broad foot (HP:0001769)1.65349347
158Increased IgM level (HP:0003496)1.65193409
159Abnormality of magnesium homeostasis (HP:0004921)1.64389471
160Congenital stationary night blindness (HP:0007642)1.64034138

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.88713916
2PBK3.74019485
3LIMK13.26206350
4ARAF3.17867422
5MAP4K23.09970908
6BCR2.91982140
7TESK22.70666645
8BMPR1B2.49795256
9MAP3K122.37786254
10CASK2.34051458
11DYRK22.32094963
12MAP3K42.14933500
13SIK32.01373184
14SRPK11.98044771
15STK391.96151915
16MST41.95162067
17BCKDK1.90284792
18TESK11.88346101
19OXSR11.86729629
20MAP3K141.77003279
21MARK11.76930815
22NEK11.59902651
23MAP3K21.56998757
24KSR21.55844809
25TSSK61.52314478
26BRAF1.50978683
27ZAK1.48007018
28BMPR21.47410232
29MINK11.44814764
30FRK1.43523633
31MAPK131.40717240
32BUB11.37890472
33MAP3K91.37011357
34ERBB31.35755518
35NUAK11.34881516
36GRK51.32326247
37PLK21.27229731
38PDK21.23643283
39PIM21.20626464
40ADRBK21.18871092
41MKNK21.18497006
42VRK11.17467809
43NEK61.15761885
44VRK21.14254021
45STK161.10217859
46CSNK1G31.08095339
47GRK71.07897132
48CDK191.03186134
49MKNK11.02857329
50YES11.00447019
51DYRK30.98442594
52PINK10.97951120
53MOS0.97921151
54EIF2AK20.97567769
55MAPKAPK50.96359204
56NTRK10.95925577
57SGK4940.92111293
58SGK2230.92111293
59PRPF4B0.90617427
60RIPK40.89937399
61TNIK0.89682092
62TIE10.88532525
63WEE10.85918258
64BLK0.85502927
65CDK140.84193524
66INSRR0.83920686
67EPHB20.82832499
68TGFBR10.79395657
69EPHB10.78345595
70EIF2AK10.77220025
71CCNB10.77045224
72CLK10.75292335
73CDK80.75269854
74FLT30.75193697
75CDK180.74361760
76PLK30.73966364
77ERBB40.73752688
78EIF2AK30.72237042
79RPS6KA40.71782863
80CSNK1G20.71543381
81MAP3K130.71428690
82PRKCE0.71268793
83KSR10.69393225
84MET0.69379934
85CSNK1G10.68865235
86GRK10.66142203
87CAMK2B0.66078270
88CAMK2D0.63615082
89ABL20.63470047
90AKT30.62847972
91EPHA40.62180079
92PLK10.61547973
93UHMK10.61342339
94MAP2K70.60465511
95CDK150.59408081
96NTRK30.58271830
97EPHA30.56637417
98CAMK2A0.56551606
99PAK30.56317369
100MAP3K50.55987387
101NLK0.53311795
102NME10.52580176
103TLK10.51373104
104IRAK40.51140513
105CAMK2G0.51037911
106IRAK10.50974178
107MATK0.50669199
108CSNK1A1L0.49512403
109AURKA0.48912751
110CDK11A0.48496643
111DYRK1B0.47502134
112RPS6KA50.47353338
113TXK0.46855514
114WNK30.46799852
115FGR0.46492917
116ADRBK10.46351544
117PAK10.46190553
118ROCK20.45603048
119MAP2K20.45510721
120MUSK0.45050436
121PKN10.44369567
122NTRK20.44334801
123MAP2K40.43346376
124IKBKB0.42531967
125IRAK20.42081092
126MYLK0.41977454
127DYRK1A0.40109778
128FER0.38851196
129ACVR1B0.38767431
130TAF10.38496854
131PRKCD0.36863567
132PLK40.36564679
133MAP2K10.35476939
134CSNK1A10.34937266
135PRKCG0.33992177
136PAK60.33929270
137DAPK10.33516572
138EGFR0.32947461
139KDR0.32472178
140TTK0.32029505
141* CSNK2A10.31024261

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.14176999
2Proteasome_Homo sapiens_hsa030503.07387120
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.56471917
4RNA polymerase_Homo sapiens_hsa030202.51349892
5Collecting duct acid secretion_Homo sapiens_hsa049662.49245503
6Parkinsons disease_Homo sapiens_hsa050122.47129844
7Protein export_Homo sapiens_hsa030602.28759505
8Rheumatoid arthritis_Homo sapiens_hsa053232.19299298
9Synaptic vesicle cycle_Homo sapiens_hsa047212.19016170
10Vibrio cholerae infection_Homo sapiens_hsa051102.13121731
11Propanoate metabolism_Homo sapiens_hsa006402.04317170
12Steroid biosynthesis_Homo sapiens_hsa001001.96763100
13Huntingtons disease_Homo sapiens_hsa050161.85083870
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.83411604
15Graft-versus-host disease_Homo sapiens_hsa053321.80118981
16Phagosome_Homo sapiens_hsa041451.75722741
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.74810388
18Alzheimers disease_Homo sapiens_hsa050101.72445266
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.72249836
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67580537
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66735377
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61693568
23Fanconi anemia pathway_Homo sapiens_hsa034601.58596858
24Phototransduction_Homo sapiens_hsa047441.56602750
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.56181319
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53365969
27Ether lipid metabolism_Homo sapiens_hsa005651.50958476
28Basal transcription factors_Homo sapiens_hsa030221.42502962
29Sulfur metabolism_Homo sapiens_hsa009201.37649640
30Butanoate metabolism_Homo sapiens_hsa006501.36806381
31Lysosome_Homo sapiens_hsa041421.26392760
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25031030
33Type I diabetes mellitus_Homo sapiens_hsa049401.22671282
34Peroxisome_Homo sapiens_hsa041461.19205392
35Serotonergic synapse_Homo sapiens_hsa047261.18592672
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16711046
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16587564
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15458802
39Allograft rejection_Homo sapiens_hsa053301.15227781
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14571184
41Shigellosis_Homo sapiens_hsa051311.12929651
42Selenocompound metabolism_Homo sapiens_hsa004501.04680503
43Pyrimidine metabolism_Homo sapiens_hsa002401.04670676
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04281352
45Autoimmune thyroid disease_Homo sapiens_hsa053201.03542376
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02607421
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.02492557
48Salmonella infection_Homo sapiens_hsa051321.02068988
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.01826835
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98533166
51Sphingolipid metabolism_Homo sapiens_hsa006000.96819229
52Base excision repair_Homo sapiens_hsa034100.96523274
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95107145
54RNA transport_Homo sapiens_hsa030130.94661444
55Pertussis_Homo sapiens_hsa051330.92897200
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92628708
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87097122
58Glutathione metabolism_Homo sapiens_hsa004800.86090171
59Leishmaniasis_Homo sapiens_hsa051400.84396247
60Regulation of autophagy_Homo sapiens_hsa041400.84113551
61Epstein-Barr virus infection_Homo sapiens_hsa051690.80393638
62Mineral absorption_Homo sapiens_hsa049780.80336632
63Prion diseases_Homo sapiens_hsa050200.79860973
64Asthma_Homo sapiens_hsa053100.79751785
65Axon guidance_Homo sapiens_hsa043600.79217334
66Nicotine addiction_Homo sapiens_hsa050330.77569289
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77306458
68Purine metabolism_Homo sapiens_hsa002300.77095865
69Homologous recombination_Homo sapiens_hsa034400.75932229
70Nitrogen metabolism_Homo sapiens_hsa009100.75381464
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72411215
72GABAergic synapse_Homo sapiens_hsa047270.72007538
73Pyruvate metabolism_Homo sapiens_hsa006200.71732222
74Fatty acid metabolism_Homo sapiens_hsa012120.71709742
75Arachidonic acid metabolism_Homo sapiens_hsa005900.71087117
76Cardiac muscle contraction_Homo sapiens_hsa042600.70495086
77Metabolic pathways_Homo sapiens_hsa011000.70183263
78Taste transduction_Homo sapiens_hsa047420.70129125
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68873520
80Tryptophan metabolism_Homo sapiens_hsa003800.68844155
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68630376
82Dopaminergic synapse_Homo sapiens_hsa047280.66477066
83Olfactory transduction_Homo sapiens_hsa047400.66025178
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65749967
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65569928
86Fatty acid elongation_Homo sapiens_hsa000620.65383559
87RNA degradation_Homo sapiens_hsa030180.64098409
88Malaria_Homo sapiens_hsa051440.62645892
89Tuberculosis_Homo sapiens_hsa051520.62607419
90Mismatch repair_Homo sapiens_hsa034300.62560241
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61294941
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59769468
93Cholinergic synapse_Homo sapiens_hsa047250.59092010
94Cell cycle_Homo sapiens_hsa041100.55915286
95African trypanosomiasis_Homo sapiens_hsa051430.55507669
96Nucleotide excision repair_Homo sapiens_hsa034200.53299891
97Legionellosis_Homo sapiens_hsa051340.53161223
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53006726
99Morphine addiction_Homo sapiens_hsa050320.51495169
100Folate biosynthesis_Homo sapiens_hsa007900.51012600
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50943595
102Other glycan degradation_Homo sapiens_hsa005110.50839623
103Renal cell carcinoma_Homo sapiens_hsa052110.49972157
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49942519
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.49584376
106Spliceosome_Homo sapiens_hsa030400.49048641
107Endocytosis_Homo sapiens_hsa041440.48803187
108Chemokine signaling pathway_Homo sapiens_hsa040620.47361127
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47344026
110Non-homologous end-joining_Homo sapiens_hsa034500.47174912
111Carbon metabolism_Homo sapiens_hsa012000.46482876
112Alcoholism_Homo sapiens_hsa050340.46439925
113Oocyte meiosis_Homo sapiens_hsa041140.45865965
114Glutamatergic synapse_Homo sapiens_hsa047240.45767934
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45489252
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42750918
117Long-term depression_Homo sapiens_hsa047300.42445433
118N-Glycan biosynthesis_Homo sapiens_hsa005100.42226888
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.42217092
120Colorectal cancer_Homo sapiens_hsa052100.41806568
121p53 signaling pathway_Homo sapiens_hsa041150.40732969
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40292008
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40092908
124Influenza A_Homo sapiens_hsa051640.39583057
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39356247
126Cocaine addiction_Homo sapiens_hsa050300.37469444
127Ras signaling pathway_Homo sapiens_hsa040140.36550172
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35570498
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35223551
130DNA replication_Homo sapiens_hsa030300.33740235
131Linoleic acid metabolism_Homo sapiens_hsa005910.33603690
132ErbB signaling pathway_Homo sapiens_hsa040120.33596067
133Apoptosis_Homo sapiens_hsa042100.33403892
134Glycosaminoglycan degradation_Homo sapiens_hsa005310.33393458
135One carbon pool by folate_Homo sapiens_hsa006700.33051984
136Arginine and proline metabolism_Homo sapiens_hsa003300.30434739
137beta-Alanine metabolism_Homo sapiens_hsa004100.28348970
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27268311
139Biosynthesis of amino acids_Homo sapiens_hsa012300.24904316

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