STARD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.09550754
2L-phenylalanine catabolic process (GO:0006559)7.09550754
3cholesterol biosynthetic process (GO:0006695)6.76999463
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.72558050
5L-phenylalanine metabolic process (GO:0006558)6.72558050
6aromatic amino acid family catabolic process (GO:0009074)6.42291538
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.02112370
8sterol biosynthetic process (GO:0016126)6.00104288
9indole-containing compound catabolic process (GO:0042436)5.80942210
10indolalkylamine catabolic process (GO:0046218)5.80942210
11tryptophan catabolic process (GO:0006569)5.80942210
12alpha-linolenic acid metabolic process (GO:0036109)5.74942112
13kynurenine metabolic process (GO:0070189)5.71391140
14bile acid biosynthetic process (GO:0006699)5.61044270
15urea metabolic process (GO:0019627)5.50930481
16urea cycle (GO:0000050)5.50930481
17tryptophan metabolic process (GO:0006568)5.50251769
18high-density lipoprotein particle remodeling (GO:0034375)5.39996475
19nuclear pore complex assembly (GO:0051292)5.31971868
20glyoxylate metabolic process (GO:0046487)5.29726071
21protein carboxylation (GO:0018214)5.20209750
22peptidyl-glutamic acid carboxylation (GO:0017187)5.20209750
23negative regulation of fibrinolysis (GO:0051918)5.19491388
24cysteine metabolic process (GO:0006534)5.16113441
25sulfur amino acid catabolic process (GO:0000098)5.04580418
26nitrogen cycle metabolic process (GO:0071941)5.02410537
27regulation of fibrinolysis (GO:0051917)4.95668277
28regulation of protein activation cascade (GO:2000257)4.94125660
29negative regulation of cholesterol transport (GO:0032375)4.90580837
30negative regulation of sterol transport (GO:0032372)4.90580837
31homocysteine metabolic process (GO:0050667)4.89229162
32bile acid metabolic process (GO:0008206)4.89196203
33complement activation, alternative pathway (GO:0006957)4.83707631
34nuclear pore organization (GO:0006999)4.82980919
35isoprenoid biosynthetic process (GO:0008299)4.76011226
36phospholipid efflux (GO:0033700)4.68043089
37aromatic amino acid family metabolic process (GO:0009072)4.67149772
38bile acid and bile salt transport (GO:0015721)4.65216509
39reverse cholesterol transport (GO:0043691)4.64082095
40regulation of triglyceride catabolic process (GO:0010896)4.62360427
41cellular glucuronidation (GO:0052695)4.60473455
42regulation of complement activation (GO:0030449)4.60444975
43regulation of cholesterol esterification (GO:0010872)4.56852521
44serine family amino acid catabolic process (GO:0009071)4.56522204
45plasma lipoprotein particle remodeling (GO:0034369)4.55550336
46protein-lipid complex remodeling (GO:0034368)4.55550336
47macromolecular complex remodeling (GO:0034367)4.55550336
48tyrosine metabolic process (GO:0006570)4.47682716
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.45235129
50acylglycerol homeostasis (GO:0055090)4.42097445
51triglyceride homeostasis (GO:0070328)4.42097445
52amino-acid betaine metabolic process (GO:0006577)4.40503026
53regulation of cholesterol homeostasis (GO:2000188)4.38971181
54intestinal cholesterol absorption (GO:0030299)4.36268585
55drug catabolic process (GO:0042737)4.34103644
56cellular ketone body metabolic process (GO:0046950)4.31501215
57plasma lipoprotein particle clearance (GO:0034381)4.22378363
58plasma lipoprotein particle assembly (GO:0034377)4.22259098
59lysine metabolic process (GO:0006553)4.22098390
60lysine catabolic process (GO:0006554)4.22098390
61indolalkylamine metabolic process (GO:0006586)4.20352952
62glycine metabolic process (GO:0006544)4.19437001
63cholesterol efflux (GO:0033344)4.18705849
64alpha-amino acid catabolic process (GO:1901606)4.14661720
65response to lipoprotein particle (GO:0055094)4.07650905
66glucuronate metabolic process (GO:0019585)4.07547082
67uronic acid metabolic process (GO:0006063)4.07547082
68imidazole-containing compound metabolic process (GO:0052803)4.07143030
69ethanol oxidation (GO:0006069)4.02839647
70benzene-containing compound metabolic process (GO:0042537)4.00644715
71flavonoid metabolic process (GO:0009812)3.98629078
72very-low-density lipoprotein particle assembly (GO:0034379)3.98318353
73amine catabolic process (GO:0009310)3.97985403
74cellular biogenic amine catabolic process (GO:0042402)3.97985403
75serine family amino acid metabolic process (GO:0009069)3.96982771
76serine family amino acid biosynthetic process (GO:0009070)3.95915763
77fibrinolysis (GO:0042730)3.91884198
78cholesterol homeostasis (GO:0042632)3.88755860
79glutamate metabolic process (GO:0006536)3.85614143
80sterol homeostasis (GO:0055092)3.84841224
81blood coagulation, intrinsic pathway (GO:0007597)3.84329293
82arginine metabolic process (GO:0006525)3.84083056
83sister chromatid segregation (GO:0000819)3.83293784
84protein-lipid complex assembly (GO:0065005)3.79447360
85cellular amino acid catabolic process (GO:0009063)3.78077556
86coenzyme catabolic process (GO:0009109)3.76437114
87regulation of bile acid biosynthetic process (GO:0070857)3.74194239
88cellular modified amino acid catabolic process (GO:0042219)3.72083634
89ketone body metabolic process (GO:1902224)3.71281079
90lipoprotein metabolic process (GO:0042157)3.71097761
91pore complex assembly (GO:0046931)3.70769369
92cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.69907636
93regulation of sister chromatid cohesion (GO:0007063)3.69478381
94short-chain fatty acid metabolic process (GO:0046459)3.66557010
95protein localization to kinetochore (GO:0034501)3.66135876
96phospholipid homeostasis (GO:0055091)3.66027551
97positive regulation of lipoprotein lipase activity (GO:0051006)3.65410523
98positive regulation of triglyceride lipase activity (GO:0061365)3.65410523
99low-density lipoprotein particle remodeling (GO:0034374)3.64938017
100positive regulation of lipid catabolic process (GO:0050996)3.64460840
101regulation of centriole replication (GO:0046599)3.61867067
102dicarboxylic acid biosynthetic process (GO:0043650)3.61063037
103plasma lipoprotein particle organization (GO:0071827)3.59917154
104exogenous drug catabolic process (GO:0042738)3.59750740
105acetyl-CoA metabolic process (GO:0006084)3.59296507
106mitotic sister chromatid segregation (GO:0000070)3.58238682
107drug transmembrane transport (GO:0006855)3.57102075
108aldehyde catabolic process (GO:0046185)3.53344281
109intestinal absorption (GO:0050892)3.53109779
110response to nitrosative stress (GO:0051409)3.50154617
111urate metabolic process (GO:0046415)3.46582546
112negative regulation of lipase activity (GO:0060192)3.46469987
113drug metabolic process (GO:0017144)3.45529627
114regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42141484
115response to follicle-stimulating hormone (GO:0032354)3.41191488
116protein localization to chromosome, centromeric region (GO:0071459)3.37498423
117layer formation in cerebral cortex (GO:0021819)3.36587745
118DNA double-strand break processing (GO:0000729)3.35962501
119mitotic sister chromatid cohesion (GO:0007064)3.28969027
120attachment of spindle microtubules to kinetochore (GO:0008608)3.26727354
121acrosome assembly (GO:0001675)3.22379327
122mitotic chromosome condensation (GO:0007076)3.12813039
123positive regulation of dendritic spine morphogenesis (GO:0061003)3.08488709
124spindle checkpoint (GO:0031577)3.05498923
125paraxial mesoderm development (GO:0048339)3.03422851
126metaphase plate congression (GO:0051310)3.02351001
127mitotic metaphase plate congression (GO:0007080)3.00089603
128mitotic spindle checkpoint (GO:0071174)2.98438209
129regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98330208
130regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98330208
131DNA topological change (GO:0006265)2.97775957
132CENP-A containing nucleosome assembly (GO:0034080)2.96848086
133mitotic G2/M transition checkpoint (GO:0044818)2.96145087
134COPII vesicle coating (GO:0048208)2.93840986
135negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89067059
136negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89067059
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89067059
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.89067059
139negative regulation of sister chromatid segregation (GO:0033046)2.89067059
140DNA unwinding involved in DNA replication (GO:0006268)2.88805079
141negative regulation of chromosome segregation (GO:0051985)2.88560409
142regulation of chromosome segregation (GO:0051983)2.87476894
143midgut development (GO:0007494)2.85969571
144chromatin remodeling at centromere (GO:0031055)2.85964689
145establishment of integrated proviral latency (GO:0075713)2.85081289
146establishment of chromosome localization (GO:0051303)2.82515627
147regulation of sister chromatid segregation (GO:0033045)2.82157753
148regulation of mitotic sister chromatid separation (GO:0010965)2.82157753
149regulation of mitotic sister chromatid segregation (GO:0033047)2.82157753
150regulation of DNA endoreduplication (GO:0032875)2.79392503
151mitotic G2 DNA damage checkpoint (GO:0007095)2.79252301
152G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.78640408
153spermatid nucleus differentiation (GO:0007289)2.77145461
154non-recombinational repair (GO:0000726)2.76852128
155double-strand break repair via nonhomologous end joining (GO:0006303)2.76852128
156kinetochore organization (GO:0051383)2.76541752
157negative regulation of striated muscle cell apoptotic process (GO:0010664)2.76469581
158mitotic spindle organization (GO:0007052)2.70107708
159mitotic spindle assembly checkpoint (GO:0007094)2.69982559
160spindle assembly checkpoint (GO:0071173)2.67306525
161negative regulation of fibroblast apoptotic process (GO:2000270)2.67295999
162regulation of development, heterochronic (GO:0040034)2.65684017
163glycolytic process (GO:0006096)2.64737671
164mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.63479303
165positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.63479303
166DNA ligation (GO:0006266)2.59614026
167embryonic foregut morphogenesis (GO:0048617)2.59112221
168regulation of transforming growth factor beta2 production (GO:0032909)2.58395435
169morphogenesis of an epithelial sheet (GO:0002011)2.57023551
170cytoplasmic mRNA processing body assembly (GO:0033962)2.56738272
171regulation of centrosome cycle (GO:0046605)2.55406560
172regulation of centrosome duplication (GO:0010824)2.55364438
173Golgi transport vesicle coating (GO:0048200)2.52952270
174COPI coating of Golgi vesicle (GO:0048205)2.52952270
175short-term memory (GO:0007614)2.49232708
176ATP-dependent chromatin remodeling (GO:0043044)2.48492763
177protein localization to chromosome (GO:0034502)2.47620883
178regulation of RNA export from nucleus (GO:0046831)2.47479652
179long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.47168214
180mitotic nuclear envelope disassembly (GO:0007077)2.47154187
181cell fate commitment involved in formation of primary germ layer (GO:0060795)2.46893301
182dorsal/ventral axis specification (GO:0009950)2.46157811
183pre-miRNA processing (GO:0031054)2.45052286
184mitotic cytokinesis (GO:0000281)2.44595583
185histone exchange (GO:0043486)2.44190808
186negative regulation of DNA recombination (GO:0045910)2.44014182
187regulation of Rac protein signal transduction (GO:0035020)2.43610382
188L-serine metabolic process (GO:0006563)2.42809893
189cytoskeleton-dependent cytokinesis (GO:0061640)2.42673201
190cell adhesion mediated by integrin (GO:0033627)2.42648227
191DNA replication-independent nucleosome organization (GO:0034724)2.42260754
192DNA replication-independent nucleosome assembly (GO:0006336)2.42260754
193positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.42232946
194positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.42232946
195positive regulation of mitotic sister chromatid separation (GO:1901970)2.42232946
196membrane disassembly (GO:0030397)2.40743123
197nuclear envelope disassembly (GO:0051081)2.40743123
198gastrulation with mouth forming second (GO:0001702)2.40591708
199DNA duplex unwinding (GO:0032508)2.39617771

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.81737645
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.80165587
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.31732369
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.15816378
5RBPJ_22232070_ChIP-Seq_NCS_Mouse4.85091269
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.74319817
7E2F7_22180533_ChIP-Seq_HELA_Human4.56474726
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.37633203
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.18477884
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.65125931
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.58918804
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.57362850
13E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14748714
14FOXM1_23109430_ChIP-Seq_U2OS_Human3.13477439
15TAF15_26573619_Chip-Seq_HEK293_Human2.84064014
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.80657782
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59958376
18* WT1_19549856_ChIP-ChIP_CCG9911_Human2.47266744
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.43274156
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.33067874
21FUS_26573619_Chip-Seq_HEK293_Human2.28457743
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.24465485
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22805710
24ELK1_19687146_ChIP-ChIP_HELA_Human2.09990565
25GBX2_23144817_ChIP-Seq_PC3_Human2.08589757
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07473786
27EWS_26573619_Chip-Seq_HEK293_Human2.05493772
28CLOCK_20551151_ChIP-Seq_293T_Human2.04067945
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03179701
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01702142
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.2359118
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94774412
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84244680
34IGF1R_20145208_ChIP-Seq_DFB_Human1.79645859
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74979178
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73504121
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70358139
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69762526
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69427112
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69220688
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68188035
42GATA1_22025678_ChIP-Seq_K562_Human1.67612431
43P300_19829295_ChIP-Seq_ESCs_Human1.66095311
44VDR_22108803_ChIP-Seq_LS180_Human1.62388452
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.60320443
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59820003
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59371600
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56878481
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56570106
50ZNF263_19887448_ChIP-Seq_K562_Human1.55906592
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.55197112
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.53397732
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51374057
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51072412
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46928249
56HTT_18923047_ChIP-ChIP_STHdh_Human1.46890777
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45180590
58GATA4_25053715_ChIP-Seq_YYC3_Human1.43898172
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43251763
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41036552
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.39146473
62SOX9_26525672_Chip-Seq_HEART_Mouse1.38116480
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37375793
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33833687
65SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33832141
66* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31507313
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30631056
68SMAD4_21799915_ChIP-Seq_A2780_Human1.30455770
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29995793
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.29563265
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.26593421
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.24439075
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23631427
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23070258
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22648846
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21287509
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.20611046
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20158287
79* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18116561
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17656291
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17620157
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.17445697
83ZNF274_21170338_ChIP-Seq_K562_Hela1.17052761
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16697686
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16245840
86NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15790304
87* TP53_18474530_ChIP-ChIP_U2OS_Human1.14902347
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14811735
89* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14364414
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14023993
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13307533
92* SMAD3_21741376_ChIP-Seq_EPCs_Human1.12140334
93EGR1_19374776_ChIP-ChIP_THP-1_Human1.11429808
94GATA6_25053715_ChIP-Seq_YYC3_Human1.11321390
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.09739188
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.09559331
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09363883
98STAT3_23295773_ChIP-Seq_U87_Human1.09312161
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09045491
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08879652
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08879652
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08879652
103* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08872015
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07040007
105MYC_18555785_ChIP-Seq_MESCs_Mouse1.06510397
106FOXO3_23340844_ChIP-Seq_DLD1_Human1.05164818
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.04793624
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04648083
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03875490
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03664478
111TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03420746
112ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03382496
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03301078
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02971180
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02663596
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02614349
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01030229
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99611556
119* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99488729
120IRF1_19129219_ChIP-ChIP_H3396_Human0.99407693
121SOX2_20726797_ChIP-Seq_SW620_Human0.99220436
122* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99190153
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99024132
124* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98357494
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.98168240
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97962860
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97804552
128REST_19997604_ChIP-ChIP_NEURONS_Mouse0.97576195
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96363546
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95981089
131* TP53_16413492_ChIP-PET_HCT116_Human0.95573361
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95089566
133* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91166689
134GATA1_19941826_ChIP-Seq_K562_Human0.88035760
135RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85161677
136SCL_19346495_ChIP-Seq_HPC-7_Human0.84815680
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.84050758
138* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.83795703
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.83509761
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82741325
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82710772
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.81858579
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79625230
144GATA2_19941826_ChIP-Seq_K562_Human0.79526500
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79040913
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76744330
147* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76478964
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75034774
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75034774
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73955291
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.72235673
152BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72188841
153AR_21909140_ChIP-Seq_LNCAP_Human0.72122310
154BRD4_27068464_Chip-Seq_AML-cells_Mouse0.70983662
155FOXA1_25552417_ChIP-Seq_VCAP_Human0.70802791
156FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69998983
157CEBPB_22108803_ChIP-Seq_LS180_Human0.67517059
158TRIM28_21343339_ChIP-Seq_HEK293_Human0.66821108
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.62345429
160HIF1A_21447827_ChIP-Seq_MCF-7_Human0.61967776
161ATF3_27146783_Chip-Seq_COLON_Human0.61959378
162MYB_21317192_ChIP-Seq_ERMYB_Mouse0.61682865
163GATA2_21666600_ChIP-Seq_HMVEC_Human0.60158332
164FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.59702522
165STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58688892
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.58377662
167* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58203598
168RACK7_27058665_Chip-Seq_MCF-7_Human0.57507594
169SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.56931672
170TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.56177052
171* RARA_24833708_ChIP-Seq_LIVER_Mouse0.55979208
172* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.55178581
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.55027062
174SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.54484526
175* GATA3_24758297_ChIP-Seq_MCF-7_Human0.54355474
176RARB_24833708_ChIP-Seq_LIVER_Mouse0.52685525
177* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.51989520
178* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.51989520
179ESR1_20079471_ChIP-ChIP_T-47D_Human0.51105368
180LXR_22292898_ChIP-Seq_THP-1_Human0.51039541
181* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.50034269
182EGR1_19032775_ChIP-ChIP_M12_Human0.48812949
183SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.48709814
184PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48202385
185* TP63_23658742_ChIP-Seq_EP156T_Human0.46622573
186RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.44142527
187KAP1_22055183_ChIP-Seq_ESCs_Mouse0.44138206
188P63_26484246_Chip-Seq_KERATINOCYTES_Human0.43888442
189* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.43802770
190SOX9_24532713_ChIP-Seq_HFSC_Mouse0.42209721
191CBP_21632823_ChIP-Seq_H3396_Human0.41610576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.14158164
2MP0005360_urolithiasis7.57877329
3* MP0005085_abnormal_gallbladder_physiolo5.90727415
4MP0005365_abnormal_bile_salt5.46000830
5MP0008875_abnormal_xenobiotic_pharmacok4.81154815
6MP0003252_abnormal_bile_duct3.75277319
7MP0003806_abnormal_nucleotide_metabolis3.70384089
8MP0005083_abnormal_biliary_tract3.22391162
9* MP0010329_abnormal_lipoprotein_level3.19957004
10MP0009840_abnormal_foam_cell3.15693563
11MP0003890_abnormal_embryonic-extraembry3.09099344
12MP0001666_abnormal_nutrient_absorption2.84850657
13MP0004272_abnormal_basement_membrane2.82619791
14MP0003122_maternal_imprinting2.67501535
15MP0003567_abnormal_fetal_cardiomyocyte2.61575668
16MP0010094_abnormal_chromosome_stability2.51136086
17MP0004957_abnormal_blastocyst_morpholog2.46524082
18MP0008057_abnormal_DNA_replication2.38028791
19MP0003195_calcinosis2.29483758
20MP0005332_abnormal_amino_acid2.28877402
21MP0003941_abnormal_skin_development2.25723180
22MP0005248_abnormal_Harderian_gland2.22161724
23MP0003077_abnormal_cell_cycle2.13632725
24MP0008932_abnormal_embryonic_tissue2.13148037
25MP0000609_abnormal_liver_physiology2.02021933
26MP0003868_abnormal_feces_composition2.00958918
27MP0003191_abnormal_cellular_cholesterol1.99920721
28MP0004019_abnormal_vitamin_homeostasis1.98968057
29MP0003111_abnormal_nucleus_morphology1.98518602
30MP0000778_abnormal_nervous_system1.91042765
31MP0002009_preneoplasia1.90106583
32MP0003937_abnormal_limbs/digits/tail_de1.89320356
33MP0003705_abnormal_hypodermis_morpholog1.88128830
34MP0000537_abnormal_urethra_morphology1.86592881
35MP0009697_abnormal_copulation1.82895076
36* MP0002118_abnormal_lipid_homeostasis1.82504121
37MP0002138_abnormal_hepatobiliary_system1.77529355
38MP0001293_anophthalmia1.75413499
39MP0005451_abnormal_body_composition1.70635857
40MP0006072_abnormal_retinal_apoptosis1.66813942
41MP0003385_abnormal_body_wall1.66666748
42MP0002697_abnormal_eye_size1.66616250
43MP0003693_abnormal_embryo_hatching1.62233229
44MP0005319_abnormal_enzyme/_coenzyme1.60769686
45MP0002938_white_spotting1.54487380
46MP0003221_abnormal_cardiomyocyte_apopto1.53935313
47MP0003984_embryonic_growth_retardation1.52424643
48MP0008058_abnormal_DNA_repair1.52388189
49MP0001672_abnormal_embryogenesis/_devel1.51506856
50MP0005380_embryogenesis_phenotype1.51506856
51MP0001177_atelectasis1.51475016
52MP0002233_abnormal_nose_morphology1.51195835
53MP0001286_abnormal_eye_development1.49808919
54MP0008007_abnormal_cellular_replicative1.48784198
55MP0010234_abnormal_vibrissa_follicle1.48748809
56MP0002088_abnormal_embryonic_growth/wei1.45635643
57MP0001529_abnormal_vocalization1.45626382
58MP0000569_abnormal_digit_pigmentation1.44895420
59MP0002796_impaired_skin_barrier1.43720548
60MP0003121_genomic_imprinting1.40340710
61MP0001984_abnormal_olfaction1.40167855
62MP0001730_embryonic_growth_arrest1.38691490
63MP0002084_abnormal_developmental_patter1.38688193
64MP0010368_abnormal_lymphatic_system1.38018162
65MP0005584_abnormal_enzyme/coenzyme_acti1.33087869
66MP0005394_taste/olfaction_phenotype1.32199263
67MP0005499_abnormal_olfactory_system1.32199263
68MP0003755_abnormal_palate_morphology1.30509966
69MP0001764_abnormal_homeostasis1.29772182
70MP0001299_abnormal_eye_distance/1.29712584
71MP0001697_abnormal_embryo_size1.27496868
72MP0004215_abnormal_myocardial_fiber1.25003000
73MP0005623_abnormal_meninges_morphology1.23580038
74MP0001915_intracranial_hemorrhage1.23466902
75MP0002085_abnormal_embryonic_tissue1.20802788
76* MP0000598_abnormal_liver_morphology1.19714340
77MP0002092_abnormal_eye_morphology1.19430219
78MP0009643_abnormal_urine_homeostasis1.18542523
79MP0003656_abnormal_erythrocyte_physiolo1.17656648
80MP0000350_abnormal_cell_proliferation1.15070518
81MP0002086_abnormal_extraembryonic_tissu1.15062648
82MP0004197_abnormal_fetal_growth/weight/1.14018834
83MP0003861_abnormal_nervous_system1.13441035
84MP0009764_decreased_sensitivity_to1.11789230
85MP0009703_decreased_birth_body1.11706554
86MP0004084_abnormal_cardiac_muscle1.10957718
87MP0000428_abnormal_craniofacial_morphol1.10397477
88MP0002751_abnormal_autonomic_nervous1.07344550
89MP0003935_abnormal_craniofacial_develop1.06000173
90MP0002111_abnormal_tail_morphology1.05533812
91MP0008438_abnormal_cutaneous_collagen1.04404118
92MP0009046_muscle_twitch1.02851572
93MP0008775_abnormal_heart_ventricle1.01160926
94MP0000358_abnormal_cell_content/1.00641737
95MP0005647_abnormal_sex_gland0.99142646
96MP0002080_prenatal_lethality0.98684024
97MP0005253_abnormal_eye_physiology0.98182822
98MP0005391_vision/eye_phenotype0.98141388
99MP0003119_abnormal_digestive_system0.96507626
100MP0005408_hypopigmentation0.96471000
101MP0005171_absent_coat_pigmentation0.95549005
102MP0009763_increased_sensitivity_to0.95528765
103MP0005464_abnormal_platelet_physiology0.95407255
104MP0005084_abnormal_gallbladder_morpholo0.95343350
105MP0003880_abnormal_central_pattern0.95029519
106MP0003186_abnormal_redox_activity0.94951390
107MP0004742_abnormal_vestibular_system0.94773794
108MP0000534_abnormal_ureter_morphology0.91702791
109MP0003942_abnormal_urinary_system0.91040904
110MP0009765_abnormal_xenobiotic_induced0.90938007
111MP0000604_amyloidosis0.89710213
112MP0003011_delayed_dark_adaptation0.89582558
113MP0002184_abnormal_innervation0.89271694
114MP0006035_abnormal_mitochondrial_morpho0.88980088
115MP0005257_abnormal_intraocular_pressure0.88750179
116MP0000432_abnormal_head_morphology0.87291213
117MP0002234_abnormal_pharynx_morphology0.86902342
118MP0003566_abnormal_cell_adhesion0.86432386
119MP0003300_gastrointestinal_ulcer0.86221074
120MP0002006_tumorigenesis0.86143824
121MP0004270_analgesia0.85870649
122MP0010307_abnormal_tumor_latency0.85034511
123MP0004947_skin_inflammation0.84065799
124MP0008469_abnormal_protein_level0.83859938
125MP0002090_abnormal_vision0.83806957
126MP0008789_abnormal_olfactory_epithelium0.83730623
127MP0004264_abnormal_extraembryonic_tissu0.83162481
128MP0002081_perinatal_lethality0.82977540
129MP0001340_abnormal_eyelid_morphology0.82381839
130MP0008877_abnormal_DNA_methylation0.81416537
131MP0005636_abnormal_mineral_homeostasis0.80752759
132MP0001879_abnormal_lymphatic_vessel0.80648442
133MP0005220_abnormal_exocrine_pancreas0.79587730
134MP0002152_abnormal_brain_morphology0.77386751
135MP0005501_abnormal_skin_physiology0.77154390
136MP0005197_abnormal_uvea_morphology0.76901364
137* MP0009642_abnormal_blood_homeostasis0.75850804
138MP0005187_abnormal_penis_morphology0.74228801
139MP0004811_abnormal_neuron_physiology0.73609307
140MP0002925_abnormal_cardiovascular_devel0.72474190
141MP0004859_abnormal_synaptic_plasticity0.72219716
142MP0003453_abnormal_keratinocyte_physiol0.71598148
143MP0002060_abnormal_skin_morphology0.69281148
144MP0009053_abnormal_anal_canal0.69185836
145MP0001243_abnormal_dermal_layer0.66588656
146MP0002254_reproductive_system_inflammat0.65565971
147MP0002876_abnormal_thyroid_physiology0.62214878
148MP0001216_abnormal_epidermal_layer0.61789955
149MP0003638_abnormal_response/metabolism_0.61014495
150MP0003436_decreased_susceptibility_to0.59110103
151MP0008873_increased_physiological_sensi0.57369979
152MP0010352_gastrointestinal_tract_polyps0.57200099
153MP0005376_homeostasis/metabolism_phenot0.56995606
154MP0009384_cardiac_valve_regurgitation0.56320755
155MP0004782_abnormal_surfactant_physiolog0.56232513
156MP0003724_increased_susceptibility_to0.55858613
157MP0004147_increased_porphyrin_level0.54864846
158MP0005167_abnormal_blood-brain_barrier0.54501331
159MP0005334_abnormal_fat_pad0.53483430
160MP0002971_abnormal_brown_adipose0.53439738
161MP0009931_abnormal_skin_appearance0.51710597
162MP0009379_abnormal_foot_pigmentation0.51159652
163MP0000465_gastrointestinal_hemorrhage0.51155072
164MP0002098_abnormal_vibrissa_morphology0.50872102
165MP0000647_abnormal_sebaceous_gland0.49567561
166MP0000579_abnormal_nail_morphology0.49468390
167MP0002136_abnormal_kidney_physiology0.48987789
168MP0000377_abnormal_hair_follicle0.48942148
169MP0000639_abnormal_adrenal_gland0.48313560
170MP0010155_abnormal_intestine_physiology0.48242285
171MP0001191_abnormal_skin_condition0.48058465
172MP0000427_abnormal_hair_cycle0.48028135
173MP0003329_amyloid_beta_deposits0.47640707
174MP0002078_abnormal_glucose_homeostasis0.46592049
175MP0001756_abnormal_urination0.46023909
176MP0002928_abnormal_bile_duct0.44834881
177MP0001661_extended_life_span0.44530314
178MP0005448_abnormal_energy_balance0.44369035
179MP0005023_abnormal_wound_healing0.42797393
180MP0000249_abnormal_blood_vessel0.42299389
181MP0003690_abnormal_glial_cell0.41814849
182MP0001845_abnormal_inflammatory_respons0.41586959
183MP0005266_abnormal_metabolism0.40066670
184MP0002877_abnormal_melanocyte_morpholog0.40008146
185MP0004381_abnormal_hair_follicle0.38825988
186MP0003718_maternal_effect0.38619385
187MP0006054_spinal_hemorrhage0.38423160
188MP0005395_other_phenotype0.38262599
189MP0010678_abnormal_skin_adnexa0.38065868
190MP0000477_abnormal_intestine_morphology0.38031572
191MP0009672_abnormal_birth_weight0.37326538

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.43750595
2Deep venous thrombosis (HP:0002625)7.20711405
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.80630737
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.65032088
5Hypobetalipoproteinemia (HP:0003563)6.48593514
6Xanthomatosis (HP:0000991)6.06510403
7Prolonged partial thromboplastin time (HP:0003645)6.01526255
8Epidermoid cyst (HP:0200040)4.86636012
9Hyperlipoproteinemia (HP:0010980)4.69513900
10Abnormality of the common coagulation pathway (HP:0010990)4.47843717
11Complement deficiency (HP:0004431)4.47177071
12Joint hemorrhage (HP:0005261)4.46453246
13Hypolipoproteinemia (HP:0010981)4.46221421
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.41082912
15Fat malabsorption (HP:0002630)4.28143745
16Cortical dysplasia (HP:0002539)4.23428792
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.10427028
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.99955349
19Hyperammonemia (HP:0001987)3.99585030
20Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95010364
21Abnormality of pyrimidine metabolism (HP:0004353)3.89550958
22Abnormality of methionine metabolism (HP:0010901)3.89215301
23Conjugated hyperbilirubinemia (HP:0002908)3.81708820
24Hyperglycinemia (HP:0002154)3.73543153
25Abnormality of the intrinsic pathway (HP:0010989)3.68613468
26Acanthocytosis (HP:0001927)3.59595544
27Abnormality of glycolysis (HP:0004366)3.59391696
28Ketosis (HP:0001946)3.51247824
29Increased serum pyruvate (HP:0003542)3.50023732
30Hypercholesterolemia (HP:0003124)3.49443413
31Hypoalphalipoproteinemia (HP:0003233)3.45988266
32Abnormality of complement system (HP:0005339)3.27949716
33Hyperbilirubinemia (HP:0002904)3.26495178
34Abnormality of serine family amino acid metabolism (HP:0010894)3.24707171
35Abnormality of glycine metabolism (HP:0010895)3.24707171
36Hypoglycemic coma (HP:0001325)3.22961126
37Termporal pattern (HP:0011008)3.15093328
38Insidious onset (HP:0003587)3.15093328
39Delayed CNS myelination (HP:0002188)3.13154205
40Scanning speech (HP:0002168)3.10976824
41Steatorrhea (HP:0002570)3.09737635
42Spontaneous abortion (HP:0005268)3.01365958
43Atonic seizures (HP:0010819)3.00668267
44Hypochromic microcytic anemia (HP:0004840)2.98282287
45Abnormal lung lobation (HP:0002101)2.97694166
46Hyperglycinuria (HP:0003108)2.96077112
47Hepatocellular carcinoma (HP:0001402)2.95798912
48Abnormality of nucleobase metabolism (HP:0010932)2.95630390
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.91776486
50Myocardial infarction (HP:0001658)2.90807089
51Papillary thyroid carcinoma (HP:0002895)2.73160128
52Increased nuchal translucency (HP:0010880)2.70756372
53Vascular calcification (HP:0004934)2.69338213
54Abnormality of fatty-acid metabolism (HP:0004359)2.68053180
55Hypoplastic pelvis (HP:0008839)2.66039353
56Supernumerary spleens (HP:0009799)2.65427126
57Gingival bleeding (HP:0000225)2.64969775
58Skin nodule (HP:0200036)2.62449935
59Malnutrition (HP:0004395)2.57791522
60Overlapping toe (HP:0001845)2.57771509
61Hemorrhage of the eye (HP:0011885)2.56432335
62Esophageal varix (HP:0002040)2.54723949
63Poikilocytosis (HP:0004447)2.53941568
64Abnormality of serum amino acid levels (HP:0003112)2.53083705
65Spastic diplegia (HP:0001264)2.51003560
66Increased mean platelet volume (HP:0011877)2.50046139
67Abnormality of purine metabolism (HP:0004352)2.48670106
68Thyroid carcinoma (HP:0002890)2.48307065
69Colon cancer (HP:0003003)2.46745078
70Menorrhagia (HP:0000132)2.46231447
71Abnormality of the labia minora (HP:0012880)2.44809348
72Nephroblastoma (Wilms tumor) (HP:0002667)2.44492435
73Ketoacidosis (HP:0001993)2.43677152
74Cardiovascular calcification (HP:0011915)2.42334102
75Medulloblastoma (HP:0002885)2.38819716
76Action tremor (HP:0002345)2.38557384
77Embryonal renal neoplasm (HP:0011794)2.38374330
78Abnormal cartilage morphology (HP:0002763)2.37154887
79Mitral stenosis (HP:0001718)2.36181228
80Hepatoblastoma (HP:0002884)2.35836996
81Metabolic acidosis (HP:0001942)2.32623731
82Abnormality of chromosome stability (HP:0003220)2.31979792
83Transitional cell carcinoma of the bladder (HP:0006740)2.27328936
84Rhabdomyosarcoma (HP:0002859)2.26474842
85Abnormal platelet volume (HP:0011876)2.25041593
86Abnormality of the lower motor neuron (HP:0002366)2.24605381
87Bifid tongue (HP:0010297)2.22034819
88Pheochromocytoma (HP:0002666)2.21341817
89Thrombophlebitis (HP:0004418)2.20328576
90Bladder carcinoma (HP:0002862)2.17713712
91Bladder neoplasm (HP:0009725)2.17713712
92Abnormal gallbladder morphology (HP:0012437)2.17111047
93Generalized hypotonia (HP:0001290)2.14699622
94Abnormal gallbladder physiology (HP:0012438)2.14073338
95Cholecystitis (HP:0001082)2.14073338
96Uterine leiomyosarcoma (HP:0002891)2.13764988
97Leiomyosarcoma (HP:0100243)2.13764988
98Volvulus (HP:0002580)2.12402691
99Hypoglycemic seizures (HP:0002173)2.11319333
100Abnormal tarsal ossification (HP:0008369)2.09926672
101Vertebral arch anomaly (HP:0008438)2.09467181
102Rickets (HP:0002748)2.08722662
103Meckel diverticulum (HP:0002245)2.06974274
104Neonatal onset (HP:0003623)2.06193570
105Myelomeningocele (HP:0002475)2.04377340
106Short humerus (HP:0005792)2.04172917
107Curly hair (HP:0002212)2.03532051
108Aplasia/hypoplasia of the humerus (HP:0006507)2.03084273
109Impaired vibration sensation in the lower limbs (HP:0002166)2.02303680
110Recurrent gram-negative bacterial infections (HP:0005420)2.01875003
111Cholelithiasis (HP:0001081)2.01718593
112Broad foot (HP:0001769)2.01652213
113Irritability (HP:0000737)2.01301012
114Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01260116
115Dicarboxylic aciduria (HP:0003215)2.01260116
116Abnormality of proline metabolism (HP:0010907)2.01092652
117Hydroxyprolinuria (HP:0003080)2.01092652
118Chromsome breakage (HP:0040012)1.99021131
119High anterior hairline (HP:0009890)1.97670084
120Malignant gastrointestinal tract tumors (HP:0006749)1.97643874
121Gastrointestinal carcinoma (HP:0002672)1.97643874
122Duodenal stenosis (HP:0100867)1.97221811
123Small intestinal stenosis (HP:0012848)1.97221811
124Abnormality of iron homeostasis (HP:0011031)1.97151541
125Abnormality of the ileum (HP:0001549)1.96185077
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96139430
127Pancreatitis (HP:0001733)1.95799182
128Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95671796
129Systemic lupus erythematosus (HP:0002725)1.95489713
130Abnormality of vitamin metabolism (HP:0100508)1.95357731
131Late onset (HP:0003584)1.93673078
132Abnormal auditory evoked potentials (HP:0006958)1.91878494
133Facial hemangioma (HP:0000329)1.91368610
134Reticulocytosis (HP:0001923)1.90906221
135Abnormality of transition element cation homeostasis (HP:0011030)1.90526727
136Exotropia (HP:0000577)1.90471262
137Hypophosphatemic rickets (HP:0004912)1.89876721
138Abnormality of the Achilles tendon (HP:0005109)1.89597204
139Postnatal microcephaly (HP:0005484)1.89403316
140Large earlobe (HP:0009748)1.88848537
141Glomerulonephritis (HP:0000099)1.87908096
142Lethargy (HP:0001254)1.87636689
143Gout (HP:0001997)1.87316227
144Alkalosis (HP:0001948)1.87107620
145Deviation of the thumb (HP:0009603)1.86975766
146Amyloidosis (HP:0011034)1.85867807
147Abnormality of the gallbladder (HP:0005264)1.85831993
148Aplasia/Hypoplasia of the uvula (HP:0010293)1.85051803
149Protuberant abdomen (HP:0001538)1.84175143
150Neuroendocrine neoplasm (HP:0100634)1.84073768
151Proximal placement of thumb (HP:0009623)1.83982071
152Abnormal enzyme/coenzyme activity (HP:0012379)1.82451154
153Drooling (HP:0002307)1.81093443
154Abnormality of the hip-girdle musculature (HP:0001445)1.80861230
155Abnormality of the musculature of the pelvis (HP:0001469)1.80861230
156Ankyloglossia (HP:0010296)1.79607806
157Abnormality of the duodenum (HP:0002246)1.79033332
158Ileus (HP:0002595)1.78783585
159Abnormality of oral frenula (HP:0000190)1.78016740
160Abnormality of the anterior horn cell (HP:0006802)1.76639316
161Degeneration of anterior horn cells (HP:0002398)1.76639316
162Polycythemia (HP:0001901)1.76380534
163Pulmonary embolism (HP:0002204)1.75875094
164Epistaxis (HP:0000421)1.75790835
165Broad palm (HP:0001169)1.75685434
166Enlarged kidneys (HP:0000105)1.73444012
167Opisthotonus (HP:0002179)1.71247525
168Arterial tortuosity (HP:0005116)1.70511822
169Joint swelling (HP:0001386)1.69928421
170Hammertoe (HP:0001765)1.69923719
171Tetraparesis (HP:0002273)1.68708883
172Premature rupture of membranes (HP:0001788)1.68448144
173Febrile seizures (HP:0002373)1.68237050
174Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67197164
175Trigonocephaly (HP:0000243)1.67047163
176Shoulder girdle muscle weakness (HP:0003547)1.65612194
177Exercise-induced muscle cramps (HP:0003710)1.62021258
178Intestinal atresia (HP:0011100)1.61171832
179Fibular aplasia (HP:0002990)1.61159220
180Ovarian neoplasm (HP:0100615)1.60283364
181Omphalocele (HP:0001539)1.56634782
182Pulmonic stenosis (HP:0001642)1.56266887
183Focal motor seizures (HP:0011153)1.56264354
184Micropenis (HP:0000054)1.56025296
185Scrotal hypoplasia (HP:0000046)1.55617922
186Vertebral hypoplasia (HP:0008417)1.54805985
187Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.54805985
188Relative macrocephaly (HP:0004482)1.54772449
189Glioma (HP:0009733)1.54743407
190Heterotopia (HP:0002282)1.54307974
1912-3 toe syndactyly (HP:0004691)1.53777413
192Uterine neoplasm (HP:0010784)1.53540797
193Abnormality of the corticospinal tract (HP:0002492)1.53312161
194Intestinal polyposis (HP:0200008)1.53218073
195Sloping forehead (HP:0000340)1.53142317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.59536640
2SIK13.48667422
3NEK93.46529946
4NEK13.45003746
5BCKDK3.39920053
6FGFR43.34475477
7TSSK63.27820209
8SRPK13.15178902
9BCR3.05181711
10EIF2AK33.03478207
11TNIK2.98081164
12ERN12.93608326
13MST1R2.86700420
14TAOK32.62152298
15TTK2.61386846
16FLT32.37072522
17MKNK12.34829073
18ERBB42.32914368
19FRK2.27986635
20BRD42.26852635
21MKNK22.24638209
22PTK62.17303502
23PLK42.14445946
24BUB12.09038610
25WEE11.95474577
26TRIM281.90006818
27TRIB31.86491357
28PLK31.83953101
29EIF2AK11.76786200
30MST41.75488710
31LATS11.75085824
32MAP3K41.74832162
33EEF2K1.74808939
34RIPK11.74320610
35PLK21.73186446
36BRSK21.67390937
37CDK61.60299543
38STK38L1.57849227
39MET1.56346840
40KDR1.54827930
41NTRK11.45919742
42FGFR21.44141840
43MAPK111.43318119
44TGFBR11.43300122
45YES11.42872127
46EPHB11.39986396
47CDC71.36522164
48ACVR1B1.36412086
49MAP3K101.33759722
50LATS21.31382284
51PNCK1.31341137
52ERBB31.30762960
53TIE11.29845346
54MAP3K141.28287011
55STK241.24073406
56MAP3K31.24030042
57TBK11.23308933
58INSRR1.22274065
59GRK61.21649080
60MAP3K21.19758628
61EPHB21.17750592
62CSK1.17582159
63RPS6KA41.17488488
64STK31.16750300
65ERBB21.16472546
66MAP4K11.16414984
67PRKG21.16360318
68TYK21.13176563
69ABL21.09376719
70LRRK21.09088918
71CSNK1A1L1.07061542
72IRAK31.05335561
73MAP3K71.04832729
74JAK21.04722955
75MAP2K21.04558710
76MAP3K111.02178810
77WNK30.98314693
78CASK0.97331170
79NEK20.97069771
80TAF10.96682026
81PLK10.96042134
82CSNK1G10.94128281
83KSR10.90827062
84PIK3CG0.89709238
85DYRK1B0.89203671
86MAP2K30.88201166
87STK100.88136888
88EPHA30.87449297
89EIF2AK20.87240161
90ZAK0.86660818
91CSNK1G30.85937137
92MAP2K70.85843079
93MAP2K40.84835493
94JAK30.84618542
95PTK20.79941462
96PINK10.79166968
97RET0.78989789
98BMPR1B0.78221909
99FGFR30.76859604
100CSNK1G20.75937653
101MAPK40.72260331
102JAK10.72021093
103ROCK20.71776492
104MAP3K80.68350371
105CHEK20.66999827
106RPS6KB20.66481811
107CLK10.66340012
108PRKAA20.64507939
109PAK40.63850178
110CAMKK20.63521682
111ATM0.63440457
112MATK0.62477878
113CDK40.61996944
114MINK10.60562090
115PIM10.59846934
116PRKCQ0.59012483
117MAP2K60.58483405
118TRPM70.58183505
119IKBKE0.57971555
120CDK180.57595814
121SCYL20.56338655
122GSK3A0.56038625
123MARK10.55240360
124MAP3K120.55227377
125ALK0.54781449
126EPHA40.54694928
127PIK3CA0.53787142
128BRSK10.53158694
129ATR0.52913221
130NTRK20.52344338
131CDK140.52165995
132PRKCZ0.51734533
133PDGFRB0.51093905
134MOS0.50288889
135CDK30.49960391
136FGFR10.49610290
137CHUK0.49119088
138MTOR0.48191782
139CDK150.47999891
140IKBKB0.47880776
141STK390.47765005
142CCNB10.47758546
143IGF1R0.47060495
144NUAK10.46930562
145PDGFRA0.45516337
146PRKACG0.45072761
147CHEK10.44578595
148MAP3K10.44379371
149CDK11A0.44182555
150EGFR0.43556028
151RAF10.42403108
152SIK30.42239145
153BTK0.41532679
154PBK0.40895012
155ITK0.40108148
156DYRK30.39330458
157TYRO30.38925498
158CDK10.38107030
159CAMK1D0.37889761
160MAP3K50.37736832
161MAP2K10.37682896
162AURKB0.36655010
163PASK0.36266708
164CSF1R0.36060301
165MELK0.35511736
166PRKCG0.34624774
167VRK10.34064218
168EPHA20.33628084
169PRKCE0.33421313
170ZAP700.32823033
171PAK20.32346449
172PDPK10.32318235
173ABL10.29953054
174GRK10.29940709
175CSNK1D0.29817668

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.36627294
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.69079216
3Nitrogen metabolism_Homo sapiens_hsa009103.48337627
4Arginine biosynthesis_Homo sapiens_hsa002202.87767353
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.83371109
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77430905
7Tryptophan metabolism_Homo sapiens_hsa003802.75272609
8Complement and coagulation cascades_Homo sapiens_hsa046102.61549176
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55592760
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.41107235
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39424768
12Protein export_Homo sapiens_hsa030602.34191105
13Fatty acid degradation_Homo sapiens_hsa000712.32441045
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26272473
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21069941
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19241808
17Steroid biosynthesis_Homo sapiens_hsa001002.18485416
18Butanoate metabolism_Homo sapiens_hsa006502.15231473
19Histidine metabolism_Homo sapiens_hsa003402.05652946
20Chemical carcinogenesis_Homo sapiens_hsa052041.98739618
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.96211400
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92090172
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91287842
24Non-homologous end-joining_Homo sapiens_hsa034501.89645049
25Caffeine metabolism_Homo sapiens_hsa002321.87459383
26Peroxisome_Homo sapiens_hsa041461.84107782
27Cell cycle_Homo sapiens_hsa041101.83118581
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.81097939
29PPAR signaling pathway_Homo sapiens_hsa033201.77727281
30Retinol metabolism_Homo sapiens_hsa008301.73705707
31Sulfur metabolism_Homo sapiens_hsa009201.70766006
32Fatty acid metabolism_Homo sapiens_hsa012121.68434788
33Bile secretion_Homo sapiens_hsa049761.66945760
34Propanoate metabolism_Homo sapiens_hsa006401.66521319
35Selenocompound metabolism_Homo sapiens_hsa004501.63450778
36Staphylococcus aureus infection_Homo sapiens_hsa051501.60431311
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58856623
38beta-Alanine metabolism_Homo sapiens_hsa004101.54935354
39Fat digestion and absorption_Homo sapiens_hsa049751.50121926
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48372439
41Phenylalanine metabolism_Homo sapiens_hsa003601.40767599
42Starch and sucrose metabolism_Homo sapiens_hsa005001.36842871
43mRNA surveillance pathway_Homo sapiens_hsa030151.36441963
44RNA transport_Homo sapiens_hsa030131.33769132
45Adherens junction_Homo sapiens_hsa045201.29347980
46Folate biosynthesis_Homo sapiens_hsa007901.28848294
47RNA degradation_Homo sapiens_hsa030181.28384142
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27680453
49Mismatch repair_Homo sapiens_hsa034301.26477843
50Tyrosine metabolism_Homo sapiens_hsa003501.24553398
51Fatty acid elongation_Homo sapiens_hsa000621.24104497
52ABC transporters_Homo sapiens_hsa020101.22740688
53Fanconi anemia pathway_Homo sapiens_hsa034601.21850317
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.20648753
55p53 signaling pathway_Homo sapiens_hsa041151.20241085
56Pyruvate metabolism_Homo sapiens_hsa006201.19721858
57Basal transcription factors_Homo sapiens_hsa030221.19401727
58Cyanoamino acid metabolism_Homo sapiens_hsa004601.16693617
59Sulfur relay system_Homo sapiens_hsa041221.15544362
60Hippo signaling pathway_Homo sapiens_hsa043901.13346416
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.10495600
62Vitamin digestion and absorption_Homo sapiens_hsa049771.04405871
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01177914
64Biosynthesis of amino acids_Homo sapiens_hsa012301.00722498
65Spliceosome_Homo sapiens_hsa030400.98981562
66MicroRNAs in cancer_Homo sapiens_hsa052060.97926627
67Oocyte meiosis_Homo sapiens_hsa041140.96864478
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94789589
69Carbon metabolism_Homo sapiens_hsa012000.93811762
70GABAergic synapse_Homo sapiens_hsa047270.91357434
71Arginine and proline metabolism_Homo sapiens_hsa003300.90884371
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89573800
73Nucleotide excision repair_Homo sapiens_hsa034200.88793214
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87847968
75Lysine degradation_Homo sapiens_hsa003100.87721006
76Nicotine addiction_Homo sapiens_hsa050330.87478334
77TGF-beta signaling pathway_Homo sapiens_hsa043500.85177744
78Long-term depression_Homo sapiens_hsa047300.84207842
79One carbon pool by folate_Homo sapiens_hsa006700.83787143
80Colorectal cancer_Homo sapiens_hsa052100.83113924
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81160831
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78465266
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78332925
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76094847
85Axon guidance_Homo sapiens_hsa043600.75159992
86Gap junction_Homo sapiens_hsa045400.75087937
87DNA replication_Homo sapiens_hsa030300.74058932
88Glutathione metabolism_Homo sapiens_hsa004800.70929285
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70421611
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70104547
91Small cell lung cancer_Homo sapiens_hsa052220.69597932
92Glutamatergic synapse_Homo sapiens_hsa047240.67893259
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67661553
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64545744
95ECM-receptor interaction_Homo sapiens_hsa045120.60997473
96Glycerolipid metabolism_Homo sapiens_hsa005610.60834501
97Basal cell carcinoma_Homo sapiens_hsa052170.60691404
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59257337
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57875209
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56912278
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53403911
102Pentose phosphate pathway_Homo sapiens_hsa000300.52561385
103Alcoholism_Homo sapiens_hsa050340.52374289
104Dopaminergic synapse_Homo sapiens_hsa047280.51969068
105Proteoglycans in cancer_Homo sapiens_hsa052050.51575517
106Tight junction_Homo sapiens_hsa045300.48257700
107Fatty acid biosynthesis_Homo sapiens_hsa000610.46595608
108HIF-1 signaling pathway_Homo sapiens_hsa040660.45290549
109Wnt signaling pathway_Homo sapiens_hsa043100.44589960
110Vitamin B6 metabolism_Homo sapiens_hsa007500.43677841
111Focal adhesion_Homo sapiens_hsa045100.40778454
112Hedgehog signaling pathway_Homo sapiens_hsa043400.40391596
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39251841
114Circadian rhythm_Homo sapiens_hsa047100.37949857
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37877849
116Metabolic pathways_Homo sapiens_hsa011000.35668984
117Pathways in cancer_Homo sapiens_hsa052000.34855213
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34562079
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34517063
120Homologous recombination_Homo sapiens_hsa034400.33686408
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33609640
122Serotonergic synapse_Homo sapiens_hsa047260.33208578
123Viral carcinogenesis_Homo sapiens_hsa052030.32509198
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31630895
125Linoleic acid metabolism_Homo sapiens_hsa005910.29444366
126Galactose metabolism_Homo sapiens_hsa000520.29396232
127Prostate cancer_Homo sapiens_hsa052150.28019028
128Endometrial cancer_Homo sapiens_hsa052130.27920136
129Long-term potentiation_Homo sapiens_hsa047200.26656203
130Prolactin signaling pathway_Homo sapiens_hsa049170.26156492
131Morphine addiction_Homo sapiens_hsa050320.25982506
132Chronic myeloid leukemia_Homo sapiens_hsa052200.24470668
133Insulin resistance_Homo sapiens_hsa049310.24370988
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.22038971
135Fructose and mannose metabolism_Homo sapiens_hsa000510.18782531
136Prion diseases_Homo sapiens_hsa050200.17857583
137Renin-angiotensin system_Homo sapiens_hsa046140.11499249
138Ovarian steroidogenesis_Homo sapiens_hsa049130.08001024
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06026864
140Hepatitis C_Homo sapiens_hsa051600.05404974
141AMPK signaling pathway_Homo sapiens_hsa041520.02841914
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.01815949
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1702794
144Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1702563
145Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1669006
146Thyroid cancer_Homo sapiens_hsa05216-0.1618991
147Legionellosis_Homo sapiens_hsa05134-0.1588258
148Insulin signaling pathway_Homo sapiens_hsa04910-0.1497322
149Ether lipid metabolism_Homo sapiens_hsa00565-0.1389930
150Amoebiasis_Homo sapiens_hsa05146-0.1380181
151Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1340549
152African trypanosomiasis_Homo sapiens_hsa05143-0.1296987
153RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1205994
154Pertussis_Homo sapiens_hsa05133-0.0973091
155Bladder cancer_Homo sapiens_hsa05219-0.0846925
156Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0768421
157Glucagon signaling pathway_Homo sapiens_hsa04922-0.0662927
158Protein digestion and absorption_Homo sapiens_hsa04974-0.0643470
159Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0523196
160Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0412428
161Mineral absorption_Homo sapiens_hsa04978-0.0223771

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