STARD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.86423550
2motile cilium assembly (GO:0044458)9.78368086
3spermatid development (GO:0007286)9.34076452
4cilium movement (GO:0003341)9.29795435
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.66731689
6piRNA metabolic process (GO:0034587)8.15987239
7male meiosis (GO:0007140)7.91631319
8synaptonemal complex organization (GO:0070193)7.58661021
9single fertilization (GO:0007338)7.57083565
10synaptonemal complex assembly (GO:0007130)7.46322190
11regulation of cilium movement (GO:0003352)7.19651440
12sperm capacitation (GO:0048240)6.91278951
13fertilization (GO:0009566)6.33126047
14spermatogenesis (GO:0007283)6.18262478
15microtubule depolymerization (GO:0007019)6.16468899
16male gamete generation (GO:0048232)6.16017151
17spermatid nucleus differentiation (GO:0007289)6.05725027
18negative regulation of inclusion body assembly (GO:0090084)6.05131721
19gamete generation (GO:0007276)5.67586362
20ventricular system development (GO:0021591)5.64488671
21DNA methylation involved in gamete generation (GO:0043046)5.43126625
22organic cation transport (GO:0015695)5.38849897
23response to pheromone (GO:0019236)5.33478562
24chromosome organization involved in meiosis (GO:0070192)5.27256721
25germ cell development (GO:0007281)5.26871033
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.19781496
27sexual reproduction (GO:0019953)5.10152757
28calcium ion-dependent exocytosis (GO:0017156)5.05603637
29regulation of inclusion body assembly (GO:0090083)5.02948245
30male meiosis I (GO:0007141)4.96280830
31single strand break repair (GO:0000012)4.88603051
32cell recognition (GO:0008037)4.83511441
33cellular ketone body metabolic process (GO:0046950)4.71689833
34meiotic nuclear division (GO:0007126)4.69726634
35glycerol ether metabolic process (GO:0006662)4.66062331
36multicellular organismal reproductive process (GO:0048609)4.45858663
37ether metabolic process (GO:0018904)4.30687623
38protein K11-linked deubiquitination (GO:0035871)4.27881382
39tachykinin receptor signaling pathway (GO:0007217)4.23475087
40ketone body metabolic process (GO:1902224)4.18425208
41microtubule severing (GO:0051013)4.16896936
42behavioral response to nicotine (GO:0035095)4.12087872
43seminiferous tubule development (GO:0072520)4.07601545
44regulation of microtubule-based movement (GO:0060632)4.06358676
45monoubiquitinated protein deubiquitination (GO:0035520)4.02492955
46chromosome condensation (GO:0030261)3.98931803
47left/right pattern formation (GO:0060972)3.97190098
48meiosis I (GO:0007127)3.94188447
49detection of light stimulus involved in visual perception (GO:0050908)3.89450732
50detection of light stimulus involved in sensory perception (GO:0050962)3.89450732
51genitalia morphogenesis (GO:0035112)3.87532468
52somite development (GO:0061053)3.85599973
53DNA packaging (GO:0006323)3.85106307
54meiotic cell cycle (GO:0051321)3.82756922
55platelet dense granule organization (GO:0060155)3.71836258
56protein-cofactor linkage (GO:0018065)3.69215693
57dopamine transport (GO:0015872)3.62874858
58centriole assembly (GO:0098534)3.62040724
59multicellular organismal development (GO:0007275)3.58192723
60DNA deamination (GO:0045006)3.57928062
61protein localization to cilium (GO:0061512)3.49730410
62cilium organization (GO:0044782)3.39404055
63sequestering of actin monomers (GO:0042989)3.39135250
64intraciliary transport (GO:0042073)3.37897525
65chaperone-mediated protein complex assembly (GO:0051131)3.36034133
66GTP biosynthetic process (GO:0006183)3.32755607
67microtubule polymerization or depolymerization (GO:0031109)3.31188524
68centriole replication (GO:0007099)3.28750193
69regulation of neurotransmitter uptake (GO:0051580)3.27920142
70cilium assembly (GO:0042384)3.26668015
71axoneme assembly (GO:0035082)3.24681592
72nucleoside diphosphate phosphorylation (GO:0006165)3.23544788
73nonmotile primary cilium assembly (GO:0035058)3.23520682
74positive regulation of mitochondrial fission (GO:0090141)3.11860866
75regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.09938648
76regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.09938648
77meiotic cell cycle process (GO:1903046)3.08875533
78indole-containing compound catabolic process (GO:0042436)3.07473351
79indolalkylamine catabolic process (GO:0046218)3.07473351
80tryptophan catabolic process (GO:0006569)3.07473351
81synapsis (GO:0007129)3.07354218
82cellular component assembly involved in morphogenesis (GO:0010927)3.06578323
83behavioral response to ethanol (GO:0048149)3.06293252
84microtubule-based movement (GO:0007018)3.05862966
85left/right axis specification (GO:0070986)3.00330107
86preassembly of GPI anchor in ER membrane (GO:0016254)3.00251355
87DNA double-strand break processing (GO:0000729)2.99350811
88regulation of action potential (GO:0098900)2.95118768
89nucleus organization (GO:0006997)2.95043257
90cilium morphogenesis (GO:0060271)2.94455042
91photoreceptor cell maintenance (GO:0045494)2.92532892
92mannosylation (GO:0097502)2.91865500
93UTP biosynthetic process (GO:0006228)2.91416596
94protein polyglutamylation (GO:0018095)2.90343301
95lactate metabolic process (GO:0006089)2.89536871
96polyol catabolic process (GO:0046174)2.86877179
97protein refolding (GO:0042026)2.86150207
98regulation of centriole replication (GO:0046599)2.84480247
99regulation of spindle checkpoint (GO:0090231)2.81901060
100ubiquinone biosynthetic process (GO:0006744)2.80388889
101alditol metabolic process (GO:0019400)2.80194863
102glycolytic process (GO:0006096)2.79706150
103mitotic sister chromatid cohesion (GO:0007064)2.78863644
104ubiquinone metabolic process (GO:0006743)2.78485677
105neural tube formation (GO:0001841)2.78300298
106gene silencing by RNA (GO:0031047)2.77682976
107endoderm formation (GO:0001706)2.75770215
108pyrimidine nucleobase catabolic process (GO:0006208)2.75266058
109protein complex biogenesis (GO:0070271)2.74015993
110establishment of protein localization to Golgi (GO:0072600)2.71619043
111regulation of synaptic transmission, dopaminergic (GO:0032225)2.71095163
112detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.70927671
113positive regulation of steroid hormone secretion (GO:2000833)2.70136424
114transmission of nerve impulse (GO:0019226)2.68273635
115L-fucose catabolic process (GO:0042355)2.67953312
116fucose catabolic process (GO:0019317)2.67953312
117L-fucose metabolic process (GO:0042354)2.67953312
118RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67190797
119tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67190797
120mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.64613703
121phosphatidylethanolamine biosynthetic process (GO:0006646)2.63145760
122behavioral response to cocaine (GO:0048148)2.63144906
123mitochondrial respiratory chain complex assembly (GO:0033108)2.62655162
124histone exchange (GO:0043486)2.61787111
125kynurenine metabolic process (GO:0070189)2.59719072
126amine catabolic process (GO:0009310)2.59309930
127cellular biogenic amine catabolic process (GO:0042402)2.59309930
128regulation of dopamine metabolic process (GO:0042053)2.58694643
129regulation of catecholamine metabolic process (GO:0042069)2.58694643
130protein targeting to Golgi (GO:0000042)2.58430686
131UTP metabolic process (GO:0046051)2.56988965
132regulation of meiosis I (GO:0060631)2.55931708
133mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55670009
134mitochondrial respiratory chain complex I assembly (GO:0032981)2.55670009
135NADH dehydrogenase complex assembly (GO:0010257)2.55670009
136interferon-gamma secretion (GO:0072643)2.55254452
137aromatic amino acid family catabolic process (GO:0009074)2.53564436
138carnitine transport (GO:0015879)2.53419995
139amino-acid betaine transport (GO:0015838)2.53419995
140indolalkylamine metabolic process (GO:0006586)2.53327911
141resolution of meiotic recombination intermediates (GO:0000712)2.52232051
142glycerol metabolic process (GO:0006071)2.50876393
143phosphatidylethanolamine metabolic process (GO:0046337)2.50478621
144cAMP catabolic process (GO:0006198)2.50202879
145cornea development in camera-type eye (GO:0061303)2.49756458
146keratinocyte development (GO:0003334)2.49080244
147glutathione derivative metabolic process (GO:1901685)2.48366034
148glutathione derivative biosynthetic process (GO:1901687)2.48366034
149sister chromatid cohesion (GO:0007062)2.45189067
150negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.44997357
151carnitine transmembrane transport (GO:1902603)2.44766105
152photoreceptor cell development (GO:0042461)2.43700878
153neuronal action potential (GO:0019228)2.43461969
154nephron epithelium morphogenesis (GO:0072088)2.43397740
155nephron tubule morphogenesis (GO:0072078)2.43397740
156regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42323047
157fusion of sperm to egg plasma membrane (GO:0007342)13.7937704
158cell wall macromolecule metabolic process (GO:0044036)13.5986640
159cell wall macromolecule catabolic process (GO:0016998)13.5986640
160sperm motility (GO:0030317)13.2613671
161cilium or flagellum-dependent cell motility (GO:0001539)11.5603913
162acrosome assembly (GO:0001675)11.5415889
163sperm-egg recognition (GO:0035036)11.2529451
164multicellular organism reproduction (GO:0032504)11.2250092
165epithelial cilium movement (GO:0003351)11.0360642
166acrosome reaction (GO:0007340)10.9030034
167axonemal dynein complex assembly (GO:0070286)10.6114263
168plasma membrane fusion (GO:0045026)10.5177625
169binding of sperm to zona pellucida (GO:0007339)10.3703919
170cell-cell recognition (GO:0009988)10.1042576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.22306377
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.01628822
3EZH2_22144423_ChIP-Seq_EOC_Human3.89723621
4IGF1R_20145208_ChIP-Seq_DFB_Human3.30479654
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.23401356
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.20536903
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.91364510
8GBX2_23144817_ChIP-Seq_PC3_Human2.74291206
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.72635506
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.59874774
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39953894
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.37258118
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21647070
14VDR_22108803_ChIP-Seq_LS180_Human2.20777460
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13631393
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.13524752
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.11544496
18P300_19829295_ChIP-Seq_ESCs_Human2.10700219
19PCGF2_27294783_Chip-Seq_NPCs_Mouse2.09803822
20CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08549376
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.08423815
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06426053
23KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.95872664
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95045559
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93928824
26* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.91837749
27EWS_26573619_Chip-Seq_HEK293_Human1.91711993
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.86149060
29ZNF274_21170338_ChIP-Seq_K562_Hela1.85038311
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84866559
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83585462
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79677572
33CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.77011375
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75950148
35TAL1_26923725_Chip-Seq_HPCs_Mouse1.75155197
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.75141814
37KAP1_22055183_ChIP-Seq_ESCs_Mouse1.74937374
38KDM2B_26808549_Chip-Seq_REH_Human1.71986702
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70225662
40STAT1_17558387_ChIP-Seq_HELA_Human1.67779695
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.67053152
42BCAT_22108803_ChIP-Seq_LS180_Human1.61616805
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61175724
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.59129972
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57946003
46* NANOG_19829295_ChIP-Seq_ESCs_Human1.57436586
47* SOX2_19829295_ChIP-Seq_ESCs_Human1.57436586
48ELK4_26923725_Chip-Seq_MESODERM_Mouse1.57152609
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.56450021
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55791220
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54217959
52IRF1_19129219_ChIP-ChIP_H3396_Human1.52776571
53* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49682936
54MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48574068
55GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47119501
56P53_22387025_ChIP-Seq_ESCs_Mouse1.46304534
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.46278829
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.45506541
59AR_25329375_ChIP-Seq_VCAP_Human1.45416938
60OCT4_18555785_Chip-Seq_ESCs_Mouse1.44402969
61SMAD4_21799915_ChIP-Seq_A2780_Human1.43309373
62CMYC_18555785_Chip-Seq_ESCs_Mouse1.43273370
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43215288
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42863900
65STAT3_23295773_ChIP-Seq_U87_Human1.42575248
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42297703
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41862805
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39374263
69WDR5_24793694_ChIP-Seq_LNCAP_Human1.38292667
70P300_18555785_Chip-Seq_ESCs_Mouse1.38245411
71TP53_22573176_ChIP-Seq_HFKS_Human1.38089163
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37661760
73CBP_20019798_ChIP-Seq_JUKART_Human1.37661760
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.37581413
75SOX2_22085726_ChIP-Seq_NPCs_Mouse1.37200629
76TCF4_22108803_ChIP-Seq_LS180_Human1.36886851
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36566167
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36566167
79GATA3_21867929_ChIP-Seq_CD8_Mouse1.35143113
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34481521
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.33655048
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33379721
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33162366
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.32395361
85RUNX2_22187159_ChIP-Seq_PCA_Human1.32191899
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30353775
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30342300
88AR_20517297_ChIP-Seq_VCAP_Human1.29595019
89TAF15_26573619_Chip-Seq_HEK293_Human1.29110784
90KLF4_18555785_Chip-Seq_ESCs_Mouse1.28955777
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28447031
92GATA3_21867929_ChIP-Seq_TH1_Mouse1.27661082
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27590581
94FOXA1_25329375_ChIP-Seq_VCAP_Human1.27590581
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.26056550
96RNF2_27304074_Chip-Seq_NSC_Mouse1.25792852
97HOXB7_26014856_ChIP-Seq_BT474_Human1.25301606
98OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23134427
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.22680860
100ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22197628
101AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22166647
102SOX2_18555785_Chip-Seq_ESCs_Mouse1.21209370
103REST_21632747_ChIP-Seq_MESCs_Mouse1.20977088
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.20597346
105CDX2_22108803_ChIP-Seq_LS180_Human1.20573908
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19636182
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19203858
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18790684
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18441441
110PU1_27457419_Chip-Seq_LIVER_Mouse1.18236886
111* TCF4_23295773_ChIP-Seq_U87_Human1.17811393
112EST1_17652178_ChIP-ChIP_JURKAT_Human1.17067171
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16860090
114FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16601899
115FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16478337
116ERA_21632823_ChIP-Seq_H3396_Human1.14647258
117NMYC_18555785_Chip-Seq_ESCs_Mouse1.14520893
118* NANOG_20526341_ChIP-Seq_ESCs_Human1.14122973
119ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13528743
120RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13225053
121CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12691316
122NCOR_22424771_ChIP-Seq_293T_Human1.12602721
123PIAS1_25552417_ChIP-Seq_VCAP_Human1.12590902
124GF1_26923725_Chip-Seq_HPCs_Mouse1.12397360
125MYC_18940864_ChIP-ChIP_HL60_Human1.11848136
126PRDM14_20953172_ChIP-Seq_ESCs_Human1.11788723
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11724689
128FOXH1_21741376_ChIP-Seq_EPCs_Human1.11492712
129VDR_23849224_ChIP-Seq_CD4+_Human1.11138501
130SOX9_26525672_Chip-Seq_HEART_Mouse1.11020220
131LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.10758160
132P53_21459846_ChIP-Seq_SAOS-2_Human1.09952262
133GATA3_21878914_ChIP-Seq_MCF-7_Human1.09434676
134NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09286888
135CTCF_18555785_Chip-Seq_ESCs_Mouse1.09175733
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08250586
137ELK1_19687146_ChIP-ChIP_HELA_Human1.07870936
138ZFX_18555785_Chip-Seq_ESCs_Mouse1.07428071
139NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06978499
140NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05402616
141PHF8_20622853_ChIP-Seq_HELA_Human1.04656681
142SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04298969
143FUS_26573619_Chip-Seq_HEK293_Human1.03946046
144ER_23166858_ChIP-Seq_MCF-7_Human1.03642754
145* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03141582
146NFYB_21822215_ChIP-Seq_K562_Human1.01387081
147TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01293659
148SALL1_21062744_ChIP-ChIP_HESCs_Human1.01096885
149SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.00595050
150MYC_19829295_ChIP-Seq_ESCs_Human1.00273612
151EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99727284
152RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99687902
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98332460
154RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97978586
155CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97583769
156PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94004131
157FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93732701
158SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93132609
159GF1B_26923725_Chip-Seq_HPCs_Mouse0.92956287
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.92841812
161TBL1_22424771_ChIP-Seq_293T_Human0.92007267
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91930916
163ERG_20517297_ChIP-Seq_VCAP_Human0.87722076
164PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87067896
165PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86534486

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.20013373
2MP0001929_abnormal_gametogenesis5.69195954
3MP0008877_abnormal_DNA_methylation4.97137245
4MP0002210_abnormal_sex_determination3.79533199
5MP0003880_abnormal_central_pattern3.65646100
6MP0002161_abnormal_fertility/fecundity3.34046702
7MP0001145_abnormal_male_reproductive3.10843585
8MP0010386_abnormal_urinary_bladder2.93877930
9MP0000372_irregular_coat_pigmentation2.83023676
10MP0000653_abnormal_sex_gland2.72512542
11MP0005084_abnormal_gallbladder_morpholo2.54389418
12MP0002837_dystrophic_cardiac_calcinosis2.17922659
13MP0005670_abnormal_white_adipose2.17348091
14MP0005410_abnormal_fertilization15.7198816
15MP0002653_abnormal_ependyma_morphology1.94591920
16MP0002876_abnormal_thyroid_physiology1.82283125
17MP0002938_white_spotting1.80781476
18MP0005623_abnormal_meninges_morphology1.77251266
19MP0009745_abnormal_behavioral_response1.76807737
20MP0008058_abnormal_DNA_repair1.70032799
21MP0001485_abnormal_pinna_reflex1.66816373
22MP0002160_abnormal_reproductive_system1.63717983
23MP0009840_abnormal_foam_cell1.63186789
24MP0001501_abnormal_sleep_pattern1.61853961
25MP0003718_maternal_effect1.50797445
26MP0006276_abnormal_autonomic_nervous1.45493506
27MP0001486_abnormal_startle_reflex1.44890860
28MP0002735_abnormal_chemical_nociception1.41059115
29MP0002272_abnormal_nervous_system1.34138287
30MP0000427_abnormal_hair_cycle1.33918698
31MP0001905_abnormal_dopamine_level1.33309923
32MP0008057_abnormal_DNA_replication1.28368435
33MP0002282_abnormal_trachea_morphology1.24008951
34MP0002572_abnormal_emotion/affect_behav1.19352384
35MP0000631_abnormal_neuroendocrine_gland1.18158748
36MP0001919_abnormal_reproductive_system1.16707150
37MP0006292_abnormal_olfactory_placode1.16083060
38MP0002557_abnormal_social/conspecific_i1.13992584
39MP0002638_abnormal_pupillary_reflex1.13238833
40MP0008995_early_reproductive_senescence1.12628726
41MP0005647_abnormal_sex_gland1.11481186
42MP0005365_abnormal_bile_salt1.11267610
43MP0005085_abnormal_gallbladder_physiolo1.09337221
44MP0004233_abnormal_muscle_weight1.06498897
45MP0001970_abnormal_pain_threshold1.06265914
46MP0003195_calcinosis1.06109069
47MP0010094_abnormal_chromosome_stability1.06031778
48MP0004142_abnormal_muscle_tone1.04732908
49MP0005187_abnormal_penis_morphology1.04712390
50MP0001765_abnormal_ion_homeostasis1.04307647
51MP0008872_abnormal_physiological_respon1.00489299
52MP0003646_muscle_fatigue0.99771368
53MP0005075_abnormal_melanosome_morpholog0.99129581
54MP0003938_abnormal_ear_development0.99052582
55MP0001529_abnormal_vocalization0.96340865
56MP0002733_abnormal_thermal_nociception0.96027871
57MP0002064_seizures0.94903506
58MP0002229_neurodegeneration0.94284544
59MP0002138_abnormal_hepatobiliary_system0.93135520
60MP0005389_reproductive_system_phenotype0.91697168
61MP0008789_abnormal_olfactory_epithelium0.91328395
62MP0003011_delayed_dark_adaptation0.90344431
63MP0009046_muscle_twitch0.89872145
64MP0001986_abnormal_taste_sensitivity0.87712064
65MP0003635_abnormal_synaptic_transmissio0.86990683
66MP0008875_abnormal_xenobiotic_pharmacok0.86597573
67MP0004885_abnormal_endolymph0.86073779
68MP0004147_increased_porphyrin_level0.83967850
69MP0002067_abnormal_sensory_capabilities0.83024151
70MP0003186_abnormal_redox_activity0.82532467
71MP0002928_abnormal_bile_duct0.81866118
72MP0001666_abnormal_nutrient_absorption0.81763107
73MP0005386_behavior/neurological_phenoty0.81555617
74MP0004924_abnormal_behavior0.81555617
75MP0003315_abnormal_perineum_morphology0.81546295
76MP0002254_reproductive_system_inflammat0.80460412
77MP0000778_abnormal_nervous_system0.77556847
78MP0001984_abnormal_olfaction0.75142635
79MP0003786_premature_aging0.73987164
80MP0008007_abnormal_cellular_replicative0.73831657
81MP0000569_abnormal_digit_pigmentation0.73704716
82MP0003136_yellow_coat_color0.73150700
83MP0002163_abnormal_gland_morphology0.70603349
84MP0002102_abnormal_ear_morphology0.69356093
85MP0002234_abnormal_pharynx_morphology0.67119695
86MP0002736_abnormal_nociception_after0.63125702
87MP0001324_abnormal_eye_pigmentation0.59605706
88MP0003111_abnormal_nucleus_morphology0.58159429
89MP0005646_abnormal_pituitary_gland0.57020552
90MP0005551_abnormal_eye_electrophysiolog0.56478693
91MP0001119_abnormal_female_reproductive0.55304010
92MP0003950_abnormal_plasma_membrane0.52622240
93MP0005636_abnormal_mineral_homeostasis0.50988272
94MP0001293_anophthalmia0.50399817
95MP0005253_abnormal_eye_physiology0.49589392
96MP0003699_abnormal_female_reproductive0.47971719
97MP0003115_abnormal_respiratory_system0.47232047
98MP0010307_abnormal_tumor_latency0.45463677
99MP0002132_abnormal_respiratory_system0.44052450
100MP0003878_abnormal_ear_physiology0.43780695
101MP0005377_hearing/vestibular/ear_phenot0.43780695
102MP0005174_abnormal_tail_pigmentation0.42369401
103MP0005391_vision/eye_phenotype0.42129167
104MP0004808_abnormal_hematopoietic_stem0.41165441
105MP0005503_abnormal_tendon_morphology0.41064106
106MP0003787_abnormal_imprinting0.39963133
107MP0004019_abnormal_vitamin_homeostasis0.38558048
108MP0000358_abnormal_cell_content/0.38367855
109MP0004742_abnormal_vestibular_system0.37997562
110MP0005379_endocrine/exocrine_gland_phen0.36556075
111MP0005171_absent_coat_pigmentation0.32094428
112MP0004133_heterotaxia0.31625241
113MP0001764_abnormal_homeostasis0.31402518
114MP0001968_abnormal_touch/_nociception0.31316699
115MP0006072_abnormal_retinal_apoptosis0.30987628
116MP0004134_abnormal_chest_morphology0.30560202
117MP0001545_abnormal_hematopoietic_system0.30034472
118MP0005397_hematopoietic_system_phenotyp0.30034472
119MP0009115_abnormal_fat_cell0.29542953
120MP0003879_abnormal_hair_cell0.28383528
121MP0002971_abnormal_brown_adipose0.27956872
122MP0004381_abnormal_hair_follicle0.27060589
123MP0002092_abnormal_eye_morphology0.24733380
124MP0005666_abnormal_adipose_tissue0.24633834
125MP0009697_abnormal_copulation0.22996202
126MP0000015_abnormal_ear_pigmentation0.22138768
127MP0002405_respiratory_system_inflammati0.21435240
128MP0004036_abnormal_muscle_relaxation0.20787968
129MP0002277_abnormal_respiratory_mucosa0.20486922
130MP0003861_abnormal_nervous_system0.19878325
131MP0002109_abnormal_limb_morphology0.19541529
132MP0005423_abnormal_somatic_nervous0.19192939
133MP0003077_abnormal_cell_cycle0.19059134
134MP0009250_abnormal_appendicular_skeleto0.19025031
135MP0006036_abnormal_mitochondrial_physio0.18908716
136MP0000313_abnormal_cell_death0.18679009
137MP0001502_abnormal_circadian_rhythm0.18346858
138MP0002693_abnormal_pancreas_physiology0.18135493
139MP0000026_abnormal_inner_ear0.18026854
140MP0000432_abnormal_head_morphology0.17969242
141MP0003045_fibrosis0.17472931
142MP0002133_abnormal_respiratory_system0.16722084
143MP0005388_respiratory_system_phenotype0.16722084
144MP0005195_abnormal_posterior_eye0.15686986
145MP0005451_abnormal_body_composition0.15576986
146MP0002108_abnormal_muscle_morphology0.15404154
147MP0001963_abnormal_hearing_physiology0.15261181
148MP0002752_abnormal_somatic_nervous0.15094856
149MP0001348_abnormal_lacrimal_gland0.15003467
150MP0001270_distended_abdomen0.14690599
151MP0000647_abnormal_sebaceous_gland0.13871212

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.76279737
2Abnormal respiratory epithelium morphology (HP:0012253)9.31087977
3Abnormal respiratory motile cilium morphology (HP:0005938)9.31087977
4Abnormal ciliary motility (HP:0012262)8.13136929
5Rhinitis (HP:0012384)7.83236973
6Chronic bronchitis (HP:0004469)7.47926946
7Nasal polyposis (HP:0100582)5.92089435
8Infertility (HP:0000789)5.80758043
9Abnormality of the nasal mucosa (HP:0000433)4.83793070
10Bronchiectasis (HP:0002110)4.52580604
11Nephronophthisis (HP:0000090)4.35346775
12Bronchitis (HP:0012387)4.33822130
13Recurrent sinusitis (HP:0011108)3.77345816
14Abnormality of macular pigmentation (HP:0008002)3.64002506
15Congenital stationary night blindness (HP:0007642)3.56677632
16Tubulointerstitial nephritis (HP:0001970)3.42671166
17Abnormality of the renal medulla (HP:0100957)3.37867160
18Male infertility (HP:0003251)3.34664839
19Severe visual impairment (HP:0001141)3.33433572
20Aplasia/hypoplasia of the uterus (HP:0008684)3.25166126
21Thyroid-stimulating hormone excess (HP:0002925)3.22667833
22Recurrent otitis media (HP:0000403)3.15429484
23Abnormal spermatogenesis (HP:0008669)2.96947365
24Medial flaring of the eyebrow (HP:0010747)2.88261371
25Tubular atrophy (HP:0000092)2.85662280
26Acute necrotizing encephalopathy (HP:0006965)2.81654289
27Abnormal rod and cone electroretinograms (HP:0008323)2.78861359
28Increased CSF lactate (HP:0002490)2.77898197
29Attenuation of retinal blood vessels (HP:0007843)2.75773562
30Abnormality of midbrain morphology (HP:0002418)2.67392315
31Molar tooth sign on MRI (HP:0002419)2.67392315
32Mitochondrial inheritance (HP:0001427)2.66615702
33Oligodactyly (hands) (HP:0001180)2.60141138
34Hypoplasia of the uterus (HP:0000013)2.58178261
35Type II lissencephaly (HP:0007260)2.53460502
36Acute encephalopathy (HP:0006846)2.52988544
37Renal cortical cysts (HP:0000803)2.52507594
38Abnormality of the renal collecting system (HP:0004742)2.52329162
39Progressive macrocephaly (HP:0004481)2.47528121
40Duplicated collecting system (HP:0000081)2.46271557
41Lipid accumulation in hepatocytes (HP:0006561)2.40931278
42Tubulointerstitial abnormality (HP:0001969)2.40383893
43Cerebellar dysplasia (HP:0007033)2.37870020
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.36694001
45Abnormal mitochondria in muscle tissue (HP:0008316)2.34687698
463-Methylglutaconic aciduria (HP:0003535)2.31723359
47Abolished electroretinogram (ERG) (HP:0000550)2.31574390
48Gaze-evoked nystagmus (HP:0000640)2.27701553
49Postaxial foot polydactyly (HP:0001830)2.25673196
50Stomach cancer (HP:0012126)2.24545107
51Recurrent bronchitis (HP:0002837)2.24418919
52Large for gestational age (HP:0001520)2.24417758
53Hyperglycinemia (HP:0002154)2.23089650
54Short tibia (HP:0005736)2.22262489
55Retinal dysplasia (HP:0007973)2.13782013
56Optic disc pallor (HP:0000543)2.12731640
57Azoospermia (HP:0000027)2.12510983
58Methylmalonic acidemia (HP:0002912)2.11988187
59Glycosuria (HP:0003076)2.08233147
60Abnormality of urine glucose concentration (HP:0011016)2.08233147
61Increased hepatocellular lipid droplets (HP:0006565)2.06679639
62Gonadotropin excess (HP:0000837)2.06029234
63Stage 5 chronic kidney disease (HP:0003774)2.04635728
64Keratoconus (HP:0000563)2.01386038
65Increased corneal curvature (HP:0100692)2.01386038
66Abnormality of the renal cortex (HP:0011035)2.00725129
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.6158656
68Dynein arm defect of respiratory motile cilia (HP:0012255)13.4434116
69Absent/shortened dynein arms (HP:0200106)13.4434116
70Abnormality of permanent molar morphology (HP:0011071)1.99347856
71Abnormality of the dental root (HP:0006486)1.99347856
72Taurodontia (HP:0000679)1.99347856
73Fibular hypoplasia (HP:0003038)1.98191023
74Lissencephaly (HP:0001339)1.97292092
75Hyperglycinuria (HP:0003108)1.96703196
76Impulsivity (HP:0100710)1.95959860
77Abnormality of molar morphology (HP:0011070)1.95483287
78Abnormality of molar (HP:0011077)1.95483287
79Pachygyria (HP:0001302)1.94432509
80Congenital hepatic fibrosis (HP:0002612)1.92496152
81Pendular nystagmus (HP:0012043)1.91391988
82Absent thumb (HP:0009777)1.91109345
83Hepatocellular necrosis (HP:0001404)1.90334012
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88808803
85Abnormality of glycine metabolism (HP:0010895)1.88440290
86Abnormality of serine family amino acid metabolism (HP:0010894)1.88440290
87Abnormality of the dental pulp (HP:0006479)1.87619538
88Broad-based gait (HP:0002136)1.87013534
89Cerebral edema (HP:0002181)1.86804382
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.86690956
91Abnormality of the fovea (HP:0000493)1.85844003
92Male pseudohermaphroditism (HP:0000037)1.84958280
93Hepatic necrosis (HP:0002605)1.83539822
94Pancreatic fibrosis (HP:0100732)1.83459919
95Congenital primary aphakia (HP:0007707)1.82850153
96Abnormality of the ileum (HP:0001549)1.81893877
97Abnormality of the labia minora (HP:0012880)1.81383197
98Sclerocornea (HP:0000647)1.81202286
99Renal Fanconi syndrome (HP:0001994)1.81164695
100Gait imbalance (HP:0002141)1.79766201
101Occipital encephalocele (HP:0002085)1.79506979
102Chronic sinusitis (HP:0011109)1.78928173
103Abnormality of DNA repair (HP:0003254)1.78277986
104Bile duct proliferation (HP:0001408)1.77405921
105Abnormal biliary tract physiology (HP:0012439)1.77405921
106Albinism (HP:0001022)1.77304131
107Absent rod-and cone-mediated responses on ERG (HP:0007688)1.76895475
108Abnormality of dentin (HP:0010299)1.76735829
109True hermaphroditism (HP:0010459)1.75881043
110Cystic liver disease (HP:0006706)1.73923551
111Limb dystonia (HP:0002451)1.73893237
112Progressive cerebellar ataxia (HP:0002073)1.73873985
113Focal motor seizures (HP:0011153)1.73048310
114Abnormal glycosylation (HP:0012345)1.72751022
115Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72751022
116Abnormal protein N-linked glycosylation (HP:0012347)1.72751022
117Abnormal protein glycosylation (HP:0012346)1.72751022
118Dyschromatopsia (HP:0007641)1.72423390
119Decreased central vision (HP:0007663)1.69901797
120Aplasia/Hypoplasia of the tongue (HP:0010295)1.69220702
121Postaxial hand polydactyly (HP:0001162)1.64291219
122Bell-shaped thorax (HP:0001591)1.61476663
123Abnormality of the lower motor neuron (HP:0002366)1.61132559
124Supernumerary spleens (HP:0009799)1.61054809
125Nephrogenic diabetes insipidus (HP:0009806)1.58128755
126Oculomotor apraxia (HP:0000657)1.58047575
127Abnormal drinking behavior (HP:0030082)1.57988886
128Polydipsia (HP:0001959)1.57988886
129Aplasia/Hypoplasia of the lens (HP:0008063)1.57279991
130Pancreatic cysts (HP:0001737)1.54146343
131Facial cleft (HP:0002006)1.53954943
132Renal dysplasia (HP:0000110)1.52336493
133Tubulointerstitial fibrosis (HP:0005576)1.50229826
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.50172389
135Chronic hepatic failure (HP:0100626)1.50115282
136Abnormality of renal excretion (HP:0011036)1.49528288
137Median cleft lip (HP:0000161)1.45808112
138Microglossia (HP:0000171)1.44796503
139Optic nerve hypoplasia (HP:0000609)1.41937948
140Short ribs (HP:0000773)1.41530584
141Asymmetric septal hypertrophy (HP:0001670)1.41487854
142Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.40894047
143Vaginal atresia (HP:0000148)1.39073070
144Genital tract atresia (HP:0001827)1.38890044
145Impaired proprioception (HP:0010831)1.37982257
146Absent frontal sinuses (HP:0002688)1.34860616
147J-shaped sella turcica (HP:0002680)1.34462065
148Poor coordination (HP:0002370)1.32760625
149Heterotopia (HP:0002282)1.32695926
150Abnormal gallbladder physiology (HP:0012438)1.32514697
151Cholecystitis (HP:0001082)1.32514697
152Optic neuritis (HP:0100653)1.27645155
153Retrobulbar optic neuritis (HP:0100654)1.27645155
154Short thorax (HP:0010306)1.26954638
155Aplasia/Hypoplasia of the fibula (HP:0006492)1.26476672
156Nephropathy (HP:0000112)1.26104995
157Vascular calcification (HP:0004934)1.26034471
158Constricted visual fields (HP:0001133)1.24081419
159Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.23056100
160Broad distal phalanx of finger (HP:0009836)1.22997902
161Spastic tetraparesis (HP:0001285)1.16102768
162Cardiovascular calcification (HP:0011915)1.15669427
163Amyotrophic lateral sclerosis (HP:0007354)1.15217979
164Hypoplasia of dental enamel (HP:0006297)1.12607043
165Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.12494509
166Absent epiphyses (HP:0010577)1.12494509
167Nephroblastoma (Wilms tumor) (HP:0002667)1.12199314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.75563386
2PDK39.75563386
3PDK26.32996722
4TESK13.78336092
5PRKD32.96770394
6ZAK2.95691579
7ICK2.78242564
8TRIM282.72480634
9ADRBK22.58046507
10NUAK12.19192958
11TAOK32.09409786
12TLK11.85597646
13PNCK1.82479664
14MAPK131.82080596
15OXSR11.73189784
16STK391.71556634
17WNK41.69575366
18PTK2B1.69116330
19MAP3K41.67369803
20INSRR1.54639552
21BCR1.52741195
22TNIK1.48915693
23NEK21.47856012
24MARK11.46840142
25EPHA41.45952814
26MAP4K21.45894187
27DYRK21.35740373
28ERBB31.35300771
29VRK21.33351735
30VRK11.31404704
31KDR1.31361458
32CDK191.16222258
33PAK31.11824836
34ACVR1B1.09396769
35STK161.08585440
36MAPK151.06473686
37PDK10.98778062
38DYRK1B0.98133264
39STK380.97858076
40BCKDK0.97083247
41IRAK10.92263086
42STK38L0.88258642
43ADRBK10.87839207
44MST40.86562554
45FGFR20.85942008
46GRK50.85768347
47PHKG20.85068671
48PHKG10.85068671
49PLK40.84404735
50TGFBR10.84398267
51PRKCE0.82683458
52CAMKK20.79533047
53STK30.78500713
54CCNB10.76576511
55PASK0.68740167
56LMTK20.67711656
57RPS6KA50.67100966
58DYRK30.64843960
59WNK10.64824543
60MAP2K20.64522568
61TTK0.62202051
62WEE10.60364537
63CDC70.60364486
64DAPK20.60321002
65LATS10.55858792
66MAP3K120.55496620
67EEF2K0.54702011
68CSNK1G20.52977284
69TNK20.52435787
70CHEK20.50225859
71MAPKAPK30.47940492
72BMPR1B0.47196894
73NTRK10.46491082
74CSNK1G30.46095170
75MINK10.44254167
76GRK70.43885007
77EPHB20.42116229
78CSNK1G10.41577839
79CHEK10.41312151
80PLK30.40974804
81ATR0.40772331
82MAP2K60.39548436
83YES10.39253819
84ROCK10.39035581
85MUSK0.38992303
86MATK0.36698525
87MAPKAPK50.36569694
88BRSK10.36342988
89PINK10.35832193
90IKBKB0.34964541
91NTRK20.33903696
92IRAK20.33636247
93PRKACA0.32934004
94PDPK10.32834091
95NEK60.32354047
96CSNK1A1L0.31975463
97TAF10.31531932
98DYRK1A0.30646909
99ATM0.29724884
100PRKCG0.28011606
101PLK10.27953821
102CAMK1G0.26332119
103CAMK10.25941570
104TYRO30.25454376
105RIPK40.21273062
106EIF2AK20.20172309
107BRSK20.19617097
108CDK30.19591289
109GRK10.18290957
110PAK10.17954680
111PKN10.17770585
112MARK30.16855995
113PAK20.16213517
114PRKCQ0.15098019
115RPS6KB10.14736815
116PBK0.13898243
117STK240.13567582
118PRKAA10.11417489
119CASK0.10674204
120MAP3K100.09166641
121CSNK2A10.09085389
122PRKG10.08961597
123CDK120.08856957
124EIF2AK10.07801371
125TESK20.07542031
126TIE10.07229570
127PRKCZ0.06403487
128STK100.06234357
129MARK20.05754340
130MTOR0.05702805
131TEC0.05138742
132EIF2AK30.05058257
133WNK30.04471417
134BRAF0.04378912
135GSK3B0.04202291
136CDK10.03874477
137CSNK2A20.03410480
138PLK20.03320711
139CLK10.02647091
140PRKCB0.02170287
141PRKACG0.01316376
142PRKACB0.01246972
143MAPK80.01019759
144FRK0.00762529
145PRKDC0.00705522
146GSK3A0.00688909
147CSNK1D0.00487643
148CDK20.00066858
149TRPM7-0.0161250
150MAP2K7-0.0161010
151AURKA-0.0141319
152SRPK1-0.0139184
153CAMK2A-0.0134110
154PIM1-0.0115058
155PIK3CG-0.0107351
156PRKCA-0.0058452
157RPS6KA1-0.0056239
158PRKCD-0.0039990

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.66108984
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.18163036
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.76464421
4Pyruvate metabolism_Homo sapiens_hsa006203.68543840
5Fatty acid biosynthesis_Homo sapiens_hsa000613.10536080
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.91578909
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.90903128
8Basal transcription factors_Homo sapiens_hsa030222.82996321
9Linoleic acid metabolism_Homo sapiens_hsa005912.81950612
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.76269550
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.70875271
12Butanoate metabolism_Homo sapiens_hsa006502.62710984
13Glucagon signaling pathway_Homo sapiens_hsa049222.61063678
14Propanoate metabolism_Homo sapiens_hsa006402.56560572
15Fanconi anemia pathway_Homo sapiens_hsa034602.52136461
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.49897097
17Oxidative phosphorylation_Homo sapiens_hsa001902.48615674
18Parkinsons disease_Homo sapiens_hsa050122.22878100
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.17084450
20Protein export_Homo sapiens_hsa030602.14102528
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.12354635
22Carbohydrate digestion and absorption_Homo sapiens_hsa049732.02918412
23Oocyte meiosis_Homo sapiens_hsa041142.00583499
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.99141614
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89558506
26Dorso-ventral axis formation_Homo sapiens_hsa043201.88279230
27Nitrogen metabolism_Homo sapiens_hsa009101.83964318
28Selenocompound metabolism_Homo sapiens_hsa004501.82596480
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81971064
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80360045
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73890730
32Glycerolipid metabolism_Homo sapiens_hsa005611.64601704
33Pentose phosphate pathway_Homo sapiens_hsa000301.58029371
34Proteasome_Homo sapiens_hsa030501.57367756
35Olfactory transduction_Homo sapiens_hsa047401.53191846
36Huntingtons disease_Homo sapiens_hsa050161.52416074
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49349904
38Peroxisome_Homo sapiens_hsa041461.46643875
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44302668
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40716889
41Purine metabolism_Homo sapiens_hsa002301.39207710
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.36417933
43Ether lipid metabolism_Homo sapiens_hsa005651.35861352
44Mineral absorption_Homo sapiens_hsa049781.35272622
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.33200778
46Nicotine addiction_Homo sapiens_hsa050331.31978137
47Amphetamine addiction_Homo sapiens_hsa050311.30097643
48Alzheimers disease_Homo sapiens_hsa050101.30076445
49Antigen processing and presentation_Homo sapiens_hsa046121.29823543
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.26337071
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.26276862
52PPAR signaling pathway_Homo sapiens_hsa033201.19767320
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.19256241
54mRNA surveillance pathway_Homo sapiens_hsa030151.15344379
55Tryptophan metabolism_Homo sapiens_hsa003801.12047001
56Renin secretion_Homo sapiens_hsa049241.09432186
57Morphine addiction_Homo sapiens_hsa050321.07569062
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07423933
59Sulfur metabolism_Homo sapiens_hsa009201.05778194
60Cardiac muscle contraction_Homo sapiens_hsa042601.05447328
61Caffeine metabolism_Homo sapiens_hsa002321.00112182
62RNA polymerase_Homo sapiens_hsa030200.99956508
63Arachidonic acid metabolism_Homo sapiens_hsa005900.98942568
64Retinol metabolism_Homo sapiens_hsa008300.98716475
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98580870
66beta-Alanine metabolism_Homo sapiens_hsa004100.97896244
67Inositol phosphate metabolism_Homo sapiens_hsa005620.95558676
68RNA transport_Homo sapiens_hsa030130.90554692
69Collecting duct acid secretion_Homo sapiens_hsa049660.89742030
70Glutathione metabolism_Homo sapiens_hsa004800.87764587
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87618372
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87578726
73Vitamin digestion and absorption_Homo sapiens_hsa049770.87019850
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86554363
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86263015
76Carbon metabolism_Homo sapiens_hsa012000.85852988
77Fructose and mannose metabolism_Homo sapiens_hsa000510.85823700
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85286868
79ABC transporters_Homo sapiens_hsa020100.84433355
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.82496138
81Calcium signaling pathway_Homo sapiens_hsa040200.81961294
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81241746
83Fat digestion and absorption_Homo sapiens_hsa049750.76415604
84Legionellosis_Homo sapiens_hsa051340.76222623
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76151056
86Circadian rhythm_Homo sapiens_hsa047100.75728678
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74191183
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73582724
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70725785
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68688454
91Homologous recombination_Homo sapiens_hsa034400.65905634
92Systemic lupus erythematosus_Homo sapiens_hsa053220.65399536
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63301796
94Fatty acid metabolism_Homo sapiens_hsa012120.60466661
95Arginine and proline metabolism_Homo sapiens_hsa003300.60346100
96Regulation of autophagy_Homo sapiens_hsa041400.59633320
97Steroid biosynthesis_Homo sapiens_hsa001000.59458872
98Chemical carcinogenesis_Homo sapiens_hsa052040.57519336
99Pyrimidine metabolism_Homo sapiens_hsa002400.56942768
100Nucleotide excision repair_Homo sapiens_hsa034200.55057565
101Primary immunodeficiency_Homo sapiens_hsa053400.54922456
102GABAergic synapse_Homo sapiens_hsa047270.54713665
103Taste transduction_Homo sapiens_hsa047420.53687981
104Insulin secretion_Homo sapiens_hsa049110.53685748
105Hedgehog signaling pathway_Homo sapiens_hsa043400.53368004
106Estrogen signaling pathway_Homo sapiens_hsa049150.53273275
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53082771
108Serotonergic synapse_Homo sapiens_hsa047260.52832930
109Fatty acid degradation_Homo sapiens_hsa000710.52559853
110Fatty acid elongation_Homo sapiens_hsa000620.50837171
111Thyroid hormone synthesis_Homo sapiens_hsa049180.49177550
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.49111521
113Pancreatic secretion_Homo sapiens_hsa049720.47615465
114Protein digestion and absorption_Homo sapiens_hsa049740.47093299
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46862525
116Ribosome_Homo sapiens_hsa030100.46715237
117Cell cycle_Homo sapiens_hsa041100.45651996
118Basal cell carcinoma_Homo sapiens_hsa052170.45346368
119Non-homologous end-joining_Homo sapiens_hsa034500.45264188
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44781678
121Sphingolipid metabolism_Homo sapiens_hsa006000.43796365
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.42868663
123Metabolic pathways_Homo sapiens_hsa011000.41989836
124Long-term potentiation_Homo sapiens_hsa047200.41276711
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40618443
126Arginine biosynthesis_Homo sapiens_hsa002200.40395463
127Measles_Homo sapiens_hsa051620.39431720
128Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39137447
129Glutamatergic synapse_Homo sapiens_hsa047240.37785514
130Base excision repair_Homo sapiens_hsa034100.36335447
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.36160008
132Endocytosis_Homo sapiens_hsa041440.35739483
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33877066
134Dopaminergic synapse_Homo sapiens_hsa047280.33684776
135cAMP signaling pathway_Homo sapiens_hsa040240.33068784
136B cell receptor signaling pathway_Homo sapiens_hsa046620.30563367
137Biosynthesis of amino acids_Homo sapiens_hsa012300.30330311
138Salivary secretion_Homo sapiens_hsa049700.29885165
139Renin-angiotensin system_Homo sapiens_hsa046140.29478385
140Circadian entrainment_Homo sapiens_hsa047130.28274042
141N-Glycan biosynthesis_Homo sapiens_hsa005100.27814635
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.27054030
143Epstein-Barr virus infection_Homo sapiens_hsa051690.26897016
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26894089
145Wnt signaling pathway_Homo sapiens_hsa043100.25325854
146Gastric acid secretion_Homo sapiens_hsa049710.24874913
147Synaptic vesicle cycle_Homo sapiens_hsa047210.24188436
148Influenza A_Homo sapiens_hsa051640.23069276
149Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22276318
150Alcoholism_Homo sapiens_hsa050340.21879279
151AMPK signaling pathway_Homo sapiens_hsa041520.21396417
152Salmonella infection_Homo sapiens_hsa051320.21035151
153DNA replication_Homo sapiens_hsa030300.20109760
154Toxoplasmosis_Homo sapiens_hsa051450.19992635
155RNA degradation_Homo sapiens_hsa030180.19548200
156Phototransduction_Homo sapiens_hsa047440.19537090
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18420727
158Adipocytokine signaling pathway_Homo sapiens_hsa049200.17924736

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