STARD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of Rho GTPase activating proteins that contain a steroidogenic acute regulatory protein related lipid transfer domain. The encoded protein localizes to focal adhesions and may be involved in regulating cell morphology. This protein may also function as a tumor suppressor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vascular endothelial growth factor signaling pathway (GO:0038084)4.52394560
2surfactant homeostasis (GO:0043129)4.21661023
3retina vasculature morphogenesis in camera-type eye (GO:0061299)3.99746723
4positive regulation of heat generation (GO:0031652)3.93085132
5positive regulation by symbiont of host defense response (GO:0052509)3.65468891
6modulation by symbiont of host defense response (GO:0052031)3.65468891
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.65468891
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.65468891
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.65468891
10modulation by symbiont of host immune response (GO:0052553)3.65468891
11indole-containing compound catabolic process (GO:0042436)3.58008868
12indolalkylamine catabolic process (GO:0046218)3.58008868
13tryptophan catabolic process (GO:0006569)3.58008868
14lymph vessel development (GO:0001945)3.54224323
15cardiac myofibril assembly (GO:0055003)3.53150297
16cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.48575781
17cellular response to ethanol (GO:0071361)3.48535862
18basement membrane organization (GO:0071711)3.48070292
19regulation of cholesterol storage (GO:0010885)3.41706042
20chemical homeostasis within a tissue (GO:0048875)3.38730386
21endothelium development (GO:0003158)3.38232215
22negative regulation of interleukin-12 production (GO:0032695)3.38166908
23apoptotic cell clearance (GO:0043277)3.35742608
24response to peptidoglycan (GO:0032494)3.31528898
25regulation of heat generation (GO:0031650)3.29540250
26neutrophil activation involved in immune response (GO:0002283)3.29290222
27regulation of interferon-beta biosynthetic process (GO:0045357)3.25251221
28myofibril assembly (GO:0030239)3.23213961
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12231679
30regulation of endothelial cell differentiation (GO:0045601)3.08520463
31kynurenine metabolic process (GO:0070189)3.07608960
32endothelial cell chemotaxis (GO:0035767)3.05960753
33regulation of fever generation (GO:0031620)3.05717087
34cellular response to thyroid hormone stimulus (GO:0097067)3.04606009
35pinocytosis (GO:0006907)3.04289357
36fatty acid transmembrane transport (GO:1902001)2.98711880
37tryptophan metabolic process (GO:0006568)2.97989909
38positive regulation of gamma-delta T cell activation (GO:0046645)2.97510176
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.96302224
40regulation of macrophage chemotaxis (GO:0010758)2.96178211
41macrophage activation involved in immune response (GO:0002281)2.93271529
42regulation of p38MAPK cascade (GO:1900744)2.92652646
43germinal center formation (GO:0002467)2.89699577
44low-density lipoprotein particle clearance (GO:0034383)2.87149475
45iron ion import (GO:0097286)2.86175404
46regulation of vitamin D biosynthetic process (GO:0060556)2.85948659
47indolalkylamine metabolic process (GO:0006586)2.84085574
48vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.83712892
49lymphangiogenesis (GO:0001946)2.82262631
50interleukin-6-mediated signaling pathway (GO:0070102)2.81497117
51positive regulation of p38MAPK cascade (GO:1900745)2.80904805
52phospholipid homeostasis (GO:0055091)2.79635069
53glomerular visceral epithelial cell development (GO:0072015)2.77534555
54plasma membrane repair (GO:0001778)2.74804986
55protein localization to endosome (GO:0036010)2.74659509
56microglial cell activation (GO:0001774)2.72215460
57negative regulation of nitric-oxide synthase activity (GO:0051001)2.71729867
58positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.69633166
59cellular response to exogenous dsRNA (GO:0071360)2.68680575
60regulation of mast cell activation (GO:0033003)2.67854512
61carnitine shuttle (GO:0006853)2.67374419
62negative regulation of nitric oxide biosynthetic process (GO:0045019)2.67296869
63lipopolysaccharide-mediated signaling pathway (GO:0031663)2.66181419
64sarcomere organization (GO:0045214)2.66041350
65regulation of sequestering of triglyceride (GO:0010889)2.64789876
66oligosaccharide catabolic process (GO:0009313)2.64466014
67positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64170017
68negative regulation of lipid storage (GO:0010888)2.63842396
69positive regulation of smooth muscle cell migration (GO:0014911)2.61943503
70cellular extravasation (GO:0045123)2.61496389
71substrate-dependent cell migration (GO:0006929)2.61153765
72blood vessel maturation (GO:0001955)2.61039254
73cell adhesion mediated by integrin (GO:0033627)2.58110424
74regulation of MHC class II biosynthetic process (GO:0045346)2.57580978
75T-helper 1 type immune response (GO:0042088)2.57304008
76wound healing, spreading of epidermal cells (GO:0035313)2.57043065
77patterning of blood vessels (GO:0001569)2.55774140
78regulation of actin filament-based movement (GO:1903115)2.54450519
79regulation of mononuclear cell migration (GO:0071675)2.53748517
80granulocyte activation (GO:0036230)2.53615324
81glomerular basement membrane development (GO:0032836)2.53374486
82regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.53273413
83cardiac muscle hypertrophy (GO:0003300)2.52449058
84negative regulation of mast cell activation (GO:0033004)2.52448738
85NAD biosynthetic process (GO:0009435)2.51310841
86positive regulation of chemokine biosynthetic process (GO:0045080)2.50924280
87regulation of chronic inflammatory response (GO:0002676)2.50464888
88positive regulation of vasculogenesis (GO:2001214)2.49980441
89positive regulation of macrophage cytokine production (GO:0060907)2.49199063
90negative regulation of granulocyte differentiation (GO:0030853)2.48637367
91monocyte chemotaxis (GO:0002548)2.47854821
92endothelial cell morphogenesis (GO:0001886)2.46593682
93regulation of interleukin-12 biosynthetic process (GO:0045075)2.45316565
94response to fluid shear stress (GO:0034405)2.45309027
95blood vessel endothelial cell migration (GO:0043534)2.45242106
96positive regulation of mast cell activation (GO:0033005)2.45176495
97morphogenesis of an endothelium (GO:0003159)2.44654198
98endothelial tube morphogenesis (GO:0061154)2.44654198
99eosinophil chemotaxis (GO:0048245)2.44635948
100coronary vasculature morphogenesis (GO:0060977)2.43424396
101regulation of mast cell activation involved in immune response (GO:0033006)2.43060325
102muscle hypertrophy (GO:0014896)2.41464590
103neutrophil activation (GO:0042119)2.41003832
104dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.40628139
105amino-acid betaine transport (GO:0015838)2.40600003
106carnitine transport (GO:0015879)2.40600003
107glomerular epithelial cell development (GO:0072310)2.40359019
108striated muscle hypertrophy (GO:0014897)2.38714188
109negative regulation of interleukin-8 production (GO:0032717)2.38216678
110positive regulation of natural killer cell activation (GO:0032816)2.37503366
111neuron projection extension involved in neuron projection guidance (GO:1902284)2.36702920
112axon extension involved in axon guidance (GO:0048846)2.36702920
113intracellular lipid transport (GO:0032365)2.36510840
114positive regulation of interferon-alpha production (GO:0032727)2.36232273
115positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.36104204
116lysine catabolic process (GO:0006554)2.36059671
117lysine metabolic process (GO:0006553)2.36059671
118nerve growth factor signaling pathway (GO:0038180)2.35434270
119positive regulation of mast cell activation involved in immune response (GO:0033008)2.35329711
120positive regulation of mast cell degranulation (GO:0043306)2.35329711
121regulation of sarcomere organization (GO:0060297)2.35295967
122ovulation from ovarian follicle (GO:0001542)2.34961388
123heart trabecula formation (GO:0060347)2.34948156
124response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.34268515
125response to host immune response (GO:0052572)2.34268515
126detection of molecule of bacterial origin (GO:0032490)2.33469071
127positive regulation of acute inflammatory response (GO:0002675)2.33245008
128regulation of vasculogenesis (GO:2001212)2.33046587
129regulation of gamma-delta T cell activation (GO:0046643)2.32876295
130positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.32752040
131amine catabolic process (GO:0009310)2.32729143
132cellular biogenic amine catabolic process (GO:0042402)2.32729143
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.32617511
134negative regulation of potassium ion transmembrane transport (GO:1901380)2.31731054
135JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.30889383
136regulation of T-helper 1 cell differentiation (GO:0045625)2.30119590
137positive regulation of cAMP-mediated signaling (GO:0043950)2.28877222
138negative regulation of cytokine production involved in immune response (GO:0002719)2.28784732
139positive regulation of NF-kappaB import into nucleus (GO:0042346)2.28537444
140response to thyroid hormone (GO:0097066)2.28473439
141carnitine transmembrane transport (GO:1902603)2.28138150
142actin-myosin filament sliding (GO:0033275)2.27236689
143muscle filament sliding (GO:0030049)2.27236689
144negative regulation of systemic arterial blood pressure (GO:0003085)2.27166625
145lipoprotein transport (GO:0042953)2.26990621
146regulation of platelet activation (GO:0010543)2.26858032
147positive regulation of developmental pigmentation (GO:0048087)2.26324436
148cell migration involved in sprouting angiogenesis (GO:0002042)2.26253397
1492-oxoglutarate metabolic process (GO:0006103)2.25114355
150relaxation of cardiac muscle (GO:0055119)2.25023192
151eosinophil migration (GO:0072677)2.24981895
152positive regulation of lipid storage (GO:0010884)2.24878100
153neutrophil mediated immunity (GO:0002446)2.24672548
154negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.24436039
155regulation of nitric oxide biosynthetic process (GO:0045428)2.24322637
156positive regulation of interleukin-6 production (GO:0032755)2.24015272
157positive regulation of nitric oxide biosynthetic process (GO:0045429)2.23485568
158glomerular filtration (GO:0003094)2.23395768
159negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.23307482
160cardiac muscle hypertrophy in response to stress (GO:0014898)2.22756613
161muscle hypertrophy in response to stress (GO:0003299)2.22756613
162cardiac muscle adaptation (GO:0014887)2.22756613
163complement activation, alternative pathway (GO:0006957)2.21538844
164ceramide catabolic process (GO:0046514)2.21358400
165regulation of chemokine biosynthetic process (GO:0045073)2.21052876
166protein K11-linked deubiquitination (GO:0035871)2.21050021
167macrophage activation (GO:0042116)2.21027296
168transcytosis (GO:0045056)2.20740414
169fibroblast migration (GO:0010761)2.20693731
170regulation of integrin activation (GO:0033623)2.20666467
171regulation of skeletal muscle contraction (GO:0014819)2.20356340
172regulation of interleukin-8 biosynthetic process (GO:0045414)2.20224981
173signal peptide processing (GO:0006465)2.19714119
174regulation of mast cell degranulation (GO:0043304)2.17151395
175regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.17125757
176regulation of interleukin-12 production (GO:0032655)2.16948963
177positive regulation of defense response to virus by host (GO:0002230)2.14334374
178positive regulation of toll-like receptor signaling pathway (GO:0034123)2.13996789
179glycosphingolipid catabolic process (GO:0046479)2.13929251
180negative regulation of cytokine secretion (GO:0050710)2.13784646
181regulation of vascular endothelial growth factor production (GO:0010574)2.13566057
182positive regulation of natural killer cell differentiation (GO:0032825)2.12169200
183regulation of membrane protein ectodomain proteolysis (GO:0051043)2.11662432
184positive regulation of interleukin-17 production (GO:0032740)2.11339434
185JAK-STAT cascade (GO:0007259)2.08994982
186regulation of growth of symbiont in host (GO:0044126)2.08278280
187negative regulation of growth of symbiont in host (GO:0044130)2.08278280
188negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.08278280
189modulation of growth of symbiont involved in interaction with host (GO:0044144)2.08278280
190positive regulation of interleukin-1 beta secretion (GO:0050718)2.08161941
191response to ATP (GO:0033198)2.07830049
192interferon-gamma-mediated signaling pathway (GO:0060333)2.07436140

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.05188014
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.58698473
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.92285606
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70673958
5* GATA2_21666600_ChIP-Seq_HMVEC_Human2.48822991
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.42186023
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.41733740
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.41310011
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.40006598
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37191299
11GBX2_23144817_ChIP-Seq_PC3_Human2.32797769
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28758245
13VDR_22108803_ChIP-Seq_LS180_Human2.28004560
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.27248543
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.20742325
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.19120384
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18032354
18CLOCK_20551151_ChIP-Seq_293T_Human2.16080890
19GATA1_22025678_ChIP-Seq_K562_Human2.15475664
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06145426
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01037454
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98239592
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97795456
24RXR_22158963_ChIP-Seq_LIVER_Mouse1.96951648
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.96641374
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.91632096
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85475105
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80338453
29PPARA_22158963_ChIP-Seq_LIVER_Mouse1.78401193
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77444096
31TBX20_22328084_ChIP-Seq_HEART_Mouse1.74656723
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.74656723
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73983601
34IGF1R_20145208_ChIP-Seq_DFB_Human1.73038044
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72156665
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.70355807
37LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69152025
38TAF15_26573619_Chip-Seq_HEK293_Human1.68732016
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67554524
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61945212
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61327902
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61287171
43* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61043452
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.60999364
45SPI1_23127762_ChIP-Seq_K562_Human1.56117946
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53912751
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53593760
48CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52880026
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.52541461
50ZNF274_21170338_ChIP-Seq_K562_Hela1.52296226
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.50807305
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48019281
53SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47108785
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46208600
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45488000
56VDR_24787735_ChIP-Seq_THP-1_Human1.41491592
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40989544
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.39795528
59GATA1_19941826_ChIP-Seq_K562_Human1.34813242
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34801158
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34763451
62ER_23166858_ChIP-Seq_MCF-7_Human1.34478841
63* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33598172
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.33587818
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.32419511
66TP53_16413492_ChIP-PET_HCT116_Human1.32157079
67PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31966295
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30874670
69P300_19829295_ChIP-Seq_ESCs_Human1.30286418
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30039862
71SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29276574
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28521017
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.27319369
74BCAT_22108803_ChIP-Seq_LS180_Human1.27033244
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25746915
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25211225
77SMAD4_21799915_ChIP-Seq_A2780_Human1.24934515
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24300494
79STAT3_23295773_ChIP-Seq_U87_Human1.24003433
80SCL_19346495_ChIP-Seq_HPC-7_Human1.22694877
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22523606
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22377273
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.20998040
84CJUN_26792858_Chip-Seq_BT549_Human1.19922802
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18922998
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18626487
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.18510779
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16161309
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15725277
90LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15039003
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15004146
92RUNX_20019798_ChIP-Seq_JUKART_Human1.14272015
93SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14151439
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13545668
95CBP_20019798_ChIP-Seq_JUKART_Human1.12859035
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12859035
97GATA2_19941826_ChIP-Seq_K562_Human1.11925567
98TCF4_23295773_ChIP-Seq_U87_Human1.11898999
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11429747
100CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11344675
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.10742381
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10534100
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10073507
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09887590
105GATA3_26560356_Chip-Seq_TH2_Human1.08990579
106FOXA2_19822575_ChIP-Seq_HepG2_Human1.08902271
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08510603
108LXR_22292898_ChIP-Seq_THP-1_Human1.08095372
109AHR_22903824_ChIP-Seq_MCF-7_Human1.06847991
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06260508
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06108828
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06108828
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06108828
114NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05982420
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05954771
116CDX2_22108803_ChIP-Seq_LS180_Human1.05190260
117WT1_19549856_ChIP-ChIP_CCG9911_Human1.04832009
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.03633204
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03137366
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02922397
121SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02657086
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02620606
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02620606
124AR_25329375_ChIP-Seq_VCAP_Human1.01574109
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.01031273
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00812641
127KDM2B_26808549_Chip-Seq_DND41_Human0.99584777
128FLI1_21867929_ChIP-Seq_TH2_Mouse0.98857155
129EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98520325
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.98113615
131TCF7_22412390_ChIP-Seq_EML_Mouse0.97617033
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97547056
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97473226
134SOX2_19829295_ChIP-Seq_ESCs_Human0.97026528
135NANOG_19829295_ChIP-Seq_ESCs_Human0.97026528
136* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96657371
137OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96207683
138NFE2_27457419_Chip-Seq_LIVER_Mouse0.95934735
139JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95736422
140SMAD3_21741376_ChIP-Seq_HESCs_Human0.95308598
141WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94531685
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.94461143
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93067986
144NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92924050
145BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92874965
146ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.92868172
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.92367241
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92176438
149VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92021316
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.90668509
151KDM2B_26808549_Chip-Seq_K562_Human0.90491125
152* RUNX2_22187159_ChIP-Seq_PCA_Human0.90449666
153RACK7_27058665_Chip-Seq_MCF-7_Human0.90433791
154CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90248154
155SOX2_20726797_ChIP-Seq_SW620_Human0.86578620
156KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.83618411
157FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80929982
158WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80757315
159TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79194696
160SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79182288
161* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77380076
162P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77187327
163P63_26484246_Chip-Seq_KERATINOCYTES_Human0.76672424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.66561833
2MP0003191_abnormal_cellular_cholesterol3.40522765
3MP0005167_abnormal_blood-brain_barrier3.27212411
4MP0003195_calcinosis3.04526156
5MP0004084_abnormal_cardiac_muscle3.03044875
6MP0004272_abnormal_basement_membrane3.02787549
7MP0001879_abnormal_lymphatic_vessel2.89007278
8MP0003828_pulmonary_edema2.82939937
9MP0005058_abnormal_lysosome_morphology2.49714251
10MP0009785_altered_susceptibility_to2.39944326
11MP0003705_abnormal_hypodermis_morpholog2.29438366
12MP0003724_increased_susceptibility_to2.16297492
13MP0005670_abnormal_white_adipose2.13920381
14MP0002837_dystrophic_cardiac_calcinosis2.13304911
15MP0000751_myopathy2.10289987
16MP0004130_abnormal_muscle_cell2.08960761
17MP0008438_abnormal_cutaneous_collagen2.07128582
18MP0004036_abnormal_muscle_relaxation2.06282880
19MP0000343_altered_response_to2.04607508
20MP0002139_abnormal_hepatobiliary_system1.97375137
21MP0004510_myositis1.96205606
22MP0003566_abnormal_cell_adhesion1.93567088
23MP0005360_urolithiasis1.92001185
24MP0002332_abnormal_exercise_endurance1.91562460
25MP0000749_muscle_degeneration1.86344462
26MP0003303_peritoneal_inflammation1.82033473
27MP0005671_abnormal_response_to1.80376099
28MP0000767_abnormal_smooth_muscle1.78900113
29MP0003279_aneurysm1.78257107
30MP0006138_congestive_heart_failure1.78193827
31MP0004215_abnormal_myocardial_fiber1.74616862
32MP0002972_abnormal_cardiac_muscle1.73644164
33MP0005397_hematopoietic_system_phenotyp1.73528735
34MP0001545_abnormal_hematopoietic_system1.73528735
35MP0001501_abnormal_sleep_pattern1.73516785
36MP0009840_abnormal_foam_cell1.73134830
37MP0001790_abnormal_immune_system1.72900762
38MP0005387_immune_system_phenotype1.72900762
39MP0005330_cardiomyopathy1.69369665
40MP0010630_abnormal_cardiac_muscle1.69306289
41MP0005000_abnormal_immune_tolerance1.69035241
42MP0005385_cardiovascular_system_phenoty1.68812675
43MP0001544_abnormal_cardiovascular_syste1.68812675
44MP0001958_emphysema1.68592158
45MP0008775_abnormal_heart_ventricle1.66186724
46MP0005025_abnormal_response_to1.63783460
47MP0009278_abnormal_bone_marrow1.62094966
48MP0003300_gastrointestinal_ulcer1.58807949
49MP0004484_altered_response_of1.55538068
50MP0003656_abnormal_erythrocyte_physiolo1.55238760
51MP0005451_abnormal_body_composition1.54026761
52MP0005165_increased_susceptibility_to1.52510821
53MP0002723_abnormal_immune_serum1.50524720
54MP0002452_abnormal_antigen_presenting1.48060211
55MP0004087_abnormal_muscle_fiber1.46344235
56MP0003690_abnormal_glial_cell1.45760116
57MP0003172_abnormal_lysosome_physiology1.41955848
58MP0003075_altered_response_to1.40560238
59MP0005666_abnormal_adipose_tissue1.38278617
60MP0002138_abnormal_hepatobiliary_system1.37185514
61MP0001800_abnormal_humoral_immune1.36659188
62MP0005620_abnormal_muscle_contractility1.34338823
63MP0005647_abnormal_sex_gland1.31508453
64MP0001835_abnormal_antigen_presentation1.30662399
65MP0005310_abnormal_salivary_gland1.30337270
66MP0003646_muscle_fatigue1.27616892
67MP0000249_abnormal_blood_vessel1.25350121
68MP0003436_decreased_susceptibility_to1.24398417
69MP0004185_abnormal_adipocyte_glucose1.24285295
70MP0002419_abnormal_innate_immunity1.23387623
71MP0001845_abnormal_inflammatory_respons1.22706168
72MP0000750_abnormal_muscle_regeneration1.22007995
73MP0009643_abnormal_urine_homeostasis1.20262516
74MP0004043_abnormal_pH_regulation1.17709825
75MP0002405_respiratory_system_inflammati1.15735105
76MP0002128_abnormal_blood_circulation1.14368943
77MP0000569_abnormal_digit_pigmentation1.12857555
78MP0002127_abnormal_cardiovascular_syste1.12335640
79MP0001819_abnormal_immune_cell1.12095117
80MP0002420_abnormal_adaptive_immunity1.11732425
81MP0006082_CNS_inflammation1.09712792
82MP0010329_abnormal_lipoprotein_level1.07004034
83MP0000230_abnormal_systemic_arterial1.06252704
84MP0001756_abnormal_urination1.03825273
85MP0001533_abnormal_skeleton_physiology1.03517067
86MP0002136_abnormal_kidney_physiology1.03299433
87MP0002998_abnormal_bone_remodeling1.02608047
88MP0005332_abnormal_amino_acid1.00184940
89MP0002295_abnormal_pulmonary_circulatio0.99614348
90MP0005464_abnormal_platelet_physiology0.99520757
91MP0004147_increased_porphyrin_level0.98069784
92MP0003950_abnormal_plasma_membrane0.97440342
93MP0005164_abnormal_response_to0.96874861
94MP0000685_abnormal_immune_system0.96758393
95MP0004947_skin_inflammation0.96359451
96MP0005535_abnormal_body_temperature0.96081117
97MP0005595_abnormal_vascular_smooth0.95543129
98MP0005266_abnormal_metabolism0.95105839
99MP0008004_abnormal_stomach_pH0.94704977
100MP0003091_abnormal_cell_migration0.94700479
101MP0002106_abnormal_muscle_physiology0.94448801
102MP0005171_absent_coat_pigmentation0.93660165
103MP0001614_abnormal_blood_vessel0.93559316
104MP0001915_intracranial_hemorrhage0.92842066
105MP0004085_abnormal_heartbeat0.92773653
106MP0003567_abnormal_fetal_cardiomyocyte0.92425076
107MP0000604_amyloidosis0.90644029
108MP0003045_fibrosis0.89673831
109MP0002148_abnormal_hypersensitivity_rea0.89455884
110MP0000266_abnormal_heart_morphology0.88749482
111MP0002925_abnormal_cardiovascular_devel0.87557581
112MP0005319_abnormal_enzyme/_coenzyme0.86309137
113MP0004782_abnormal_surfactant_physiolog0.86004039
114MP0005623_abnormal_meninges_morphology0.85148154
115MP0009780_abnormal_chondrocyte_physiolo0.84792012
116MP0005375_adipose_tissue_phenotype0.84528570
117MP0004883_abnormal_blood_vessel0.84499589
118MP0003252_abnormal_bile_duct0.83722441
119MP0004145_abnormal_muscle_electrophysio0.83718693
120MP0009115_abnormal_fat_cell0.83575540
121MP0001764_abnormal_homeostasis0.83536843
122MP0010155_abnormal_intestine_physiology0.81827801
123MP0002269_muscular_atrophy0.81360394
124MP0005253_abnormal_eye_physiology0.80493238
125MP0008469_abnormal_protein_level0.80311760
126MP0005166_decreased_susceptibility_to0.80204440
127MP0002254_reproductive_system_inflammat0.80181556
128MP0005275_abnormal_skin_tensile0.80096122
129MP0003633_abnormal_nervous_system0.79740742
130MP0009764_decreased_sensitivity_to0.79713101
131MP0010386_abnormal_urinary_bladder0.79562343
132MP0001853_heart_inflammation0.79272859
133MP0004019_abnormal_vitamin_homeostasis0.78102389
134MP0000465_gastrointestinal_hemorrhage0.77342348
135MP0006054_spinal_hemorrhage0.76738813
136MP0008875_abnormal_xenobiotic_pharmacok0.75705528
137MP0005410_abnormal_fertilization0.74368488
138MP0008057_abnormal_DNA_replication0.74148670
139MP0002933_joint_inflammation0.72966121
140MP0005369_muscle_phenotype0.72514451
141MP0009763_increased_sensitivity_to0.71957216
142MP0000689_abnormal_spleen_morphology0.71914412
143MP0005334_abnormal_fat_pad0.71755556
144MP0000716_abnormal_immune_system0.71708789
145MP0005376_homeostasis/metabolism_phenot0.71200560
146MP0005551_abnormal_eye_electrophysiolog0.68775295
147MP0001986_abnormal_taste_sensitivity0.68163424
148MP0000920_abnormal_myelination0.66472623

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)5.15468802
2Abnormality of liposaccharide metabolism (HP:0010968)4.87631277
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.87631277
4Abnormality of glycolipid metabolism (HP:0010969)4.87631277
5Hematochezia (HP:0002573)4.50794026
6Spontaneous hematomas (HP:0007420)4.23729687
7Glomerulonephritis (HP:0000099)4.04765811
8Stomatitis (HP:0010280)3.96215916
9Exercise-induced muscle cramps (HP:0003710)3.83243229
10Ventricular tachycardia (HP:0004756)3.82579332
11Complement deficiency (HP:0004431)3.73278070
12Sudden death (HP:0001699)3.72174678
13Retrobulbar optic neuritis (HP:0100654)3.61353236
14Optic neuritis (HP:0100653)3.61353236
15Asymmetric septal hypertrophy (HP:0001670)3.56497391
16Cerebral aneurysm (HP:0004944)3.52926826
17Polycythemia (HP:0001901)3.42268695
18Autoimmune thrombocytopenia (HP:0001973)3.38997760
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.32886624
20Increased connective tissue (HP:0009025)3.32583801
21Nephritis (HP:0000123)3.30986654
22Axonal loss (HP:0003447)3.29195647
23Muscle fiber splitting (HP:0003555)3.28306106
24Orchitis (HP:0100796)3.26433956
25Myositis (HP:0100614)3.15302042
26Abnormality of complement system (HP:0005339)3.13627952
27Recurrent abscess formation (HP:0002722)3.03997893
28Esophageal varix (HP:0002040)2.99691111
29Lymphangioma (HP:0100764)2.90009179
30Keratoconjunctivitis (HP:0001096)2.81308649
31Atrial fibrillation (HP:0005110)2.77228819
32Increased cerebral lipofuscin (HP:0011813)2.74785765
33Hyperactive renin-angiotensin system (HP:0000841)2.73491968
34Hyporeflexia of lower limbs (HP:0002600)2.72002649
35Keratoconjunctivitis sicca (HP:0001097)2.69649509
36Lipoatrophy (HP:0100578)2.68717629
37Exercise-induced myalgia (HP:0003738)2.66116306
38Right ventricular cardiomyopathy (HP:0011663)2.65747809
39Recurrent bacterial skin infections (HP:0005406)2.65304666
40Hypokalemic alkalosis (HP:0001949)2.62563385
41Abnormality of the left ventricular outflow tract (HP:0011103)2.62301252
42Subaortic stenosis (HP:0001682)2.62301252
43Dysostosis multiplex (HP:0000943)2.61994957
44Abnormality of the periventricular white matter (HP:0002518)2.61802760
45Broad metatarsal (HP:0001783)2.61241434
46Vacuolated lymphocytes (HP:0001922)2.60097160
47Congenital stationary night blindness (HP:0007642)2.56135238
48Attenuation of retinal blood vessels (HP:0007843)2.54754240
49Calf muscle hypertrophy (HP:0008981)2.52872669
50Clumsiness (HP:0002312)2.52228092
51Eczematoid dermatitis (HP:0000976)2.51398311
52Primary atrial arrhythmia (HP:0001692)2.49782300
53Hemoptysis (HP:0002105)2.49021299
54Supraventricular arrhythmia (HP:0005115)2.45047212
55Hyperventilation (HP:0002883)2.40810948
56Recurrent gram-negative bacterial infections (HP:0005420)2.39434462
57Prolonged bleeding time (HP:0003010)2.39297284
58Difficulty running (HP:0009046)2.36324418
59Abnormality of chloride homeostasis (HP:0011422)2.36042920
60Visceral angiomatosis (HP:0100761)2.35744496
61Abnormality of the calf musculature (HP:0001430)2.33703911
62Bone cyst (HP:0012062)2.33570587
63Thick nail (HP:0001805)2.32246117
64Supraventricular tachycardia (HP:0004755)2.32183808
65Myoglobinuria (HP:0002913)2.31956462
66Increased circulating renin level (HP:0000848)2.30370878
67Abnormal drinking behavior (HP:0030082)2.30351686
68Polydipsia (HP:0001959)2.30351686
69Metabolic alkalosis (HP:0200114)2.30075496
70Abnormality of the vasculature of the conjunctiva (HP:0008054)2.26577754
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.22401385
72Muscle hypertrophy of the lower extremities (HP:0008968)2.21801005
73Loss of speech (HP:0002371)2.21795292
74Hemangiomatosis (HP:0007461)2.21779318
75Distal lower limb muscle weakness (HP:0009053)2.19486405
76EMG: myopathic abnormalities (HP:0003458)2.17148800
77Episodic fever (HP:0001954)2.16548244
78Abolished electroretinogram (ERG) (HP:0000550)2.15499879
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14711506
80Conjunctival telangiectasia (HP:0000524)2.14408162
81Prostate neoplasm (HP:0100787)2.14058824
82Congenital sensorineural hearing impairment (HP:0008527)2.11000892
83Polyneuropathy (HP:0001271)2.10140836
84Mucopolysacchariduria (HP:0008155)2.09665904
85Urinary glycosaminoglycan excretion (HP:0003541)2.09665904
86Joint hemorrhage (HP:0005261)2.09642951
87Mediastinal lymphadenopathy (HP:0100721)2.09341588
88Albinism (HP:0001022)2.09174896
89Pulmonary infiltrates (HP:0002113)2.08886436
90Aneurysm (HP:0002617)2.08861860
91Abnormality of the nasal mucosa (HP:0000433)2.08784060
92Elevated erythrocyte sedimentation rate (HP:0003565)2.08653040
93Vertigo (HP:0002321)2.08360786
94Disinhibition (HP:0000734)2.07753742
95Dilated cardiomyopathy (HP:0001644)2.06597267
96Autoimmune hemolytic anemia (HP:0001890)2.06420214
97Deep venous thrombosis (HP:0002625)2.05642307
98Arterial thrombosis (HP:0004420)2.05467784
99Cerebral hemorrhage (HP:0001342)2.04728814
100Myocardial infarction (HP:0001658)2.01352949
101Pulmonary artery stenosis (HP:0004415)2.00996864
102Increased CSF protein (HP:0002922)2.00815467
103Portal hypertension (HP:0001409)2.00136710
104Abnormality of transition element cation homeostasis (HP:0011030)1.99195513
105Hemorrhage of the eye (HP:0011885)1.98770999
106Pancreatic cysts (HP:0001737)1.98194769
107Aortic aneurysm (HP:0004942)1.98148594
108Leukocytosis (HP:0001974)1.97989434
109Abnormality of polysaccharide metabolism (HP:0011012)1.97824603
110Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97824603
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97824603
112Hypoglycemic coma (HP:0001325)1.97119490
113Protruding tongue (HP:0010808)1.96557021
114Gout (HP:0001997)1.95988712
115Pulmonary embolism (HP:0002204)1.95667183
116Fair hair (HP:0002286)1.95217603
117Mucosal telangiectasiae (HP:0100579)1.93716922
118Urethral obstruction (HP:0000796)1.93677232
119Facial diplegia (HP:0001349)1.93646251
120Absent speech (HP:0001344)1.92387656
121Hyperaldosteronism (HP:0000859)1.91526564
122Epistaxis (HP:0000421)1.90864446
123Tubular atrophy (HP:0000092)1.90837077
124Syncope (HP:0001279)1.89891979
125Abnormality of binocular vision (HP:0011514)1.89705099
126Diplopia (HP:0000651)1.89705099
127Abnormality of iron homeostasis (HP:0011031)1.89051815
128Abnormality of macrophages (HP:0004311)1.89031166
129Hypoalphalipoproteinemia (HP:0003233)1.88520051
130Hyperglycinuria (HP:0003108)1.87847850
131Abnormality of the renal cortex (HP:0011035)1.86117869
132Hypoplastic ischia (HP:0003175)1.86080898
133Abnormality of the hepatic vasculature (HP:0006707)1.85983838
134Abnormal urine output (HP:0012590)1.85808422
135Increased variability in muscle fiber diameter (HP:0003557)1.85549159
136Increased serum ferritin (HP:0003281)1.84752080
137Polyuria (HP:0000103)1.84664382
138Ketoacidosis (HP:0001993)1.84455132
139Mutism (HP:0002300)1.84306192
140Mesangial abnormality (HP:0001966)1.84241357
141Stomach cancer (HP:0012126)1.84235705
142Petechiae (HP:0000967)1.84105144
143Bundle branch block (HP:0011710)1.84083195
144Abnormality of renin-angiotensin system (HP:0000847)1.83629410
145Abnormality of purine metabolism (HP:0004352)1.83226930
146Chondrocalcinosis (HP:0000934)1.82404745
147Progressive visual loss (HP:0000529)1.82172564
148Abnormality of fatty-acid metabolism (HP:0004359)1.81996323
149Abnormality of proline metabolism (HP:0010907)1.81952612
150Hydroxyprolinuria (HP:0003080)1.81952612
151Cavernous hemangioma (HP:0001048)1.81648196
152Decreased circulating renin level (HP:0003351)1.80929469
153Nuclear cataract (HP:0100018)1.80289306
154Testicular atrophy (HP:0000029)1.80044040
155Generalized muscle weakness (HP:0003324)1.80032708
156Tubulointerstitial fibrosis (HP:0005576)1.79720201
157Recurrent fungal infections (HP:0002841)1.78114827
158Prolonged QT interval (HP:0001657)1.77502756
159Tetany (HP:0001281)1.75851415
160Hypercholesterolemia (HP:0003124)1.75744805
161Abnormality of the ischium (HP:0003174)1.75219056
162Paralysis (HP:0003470)1.75168301
163Gaze-evoked nystagmus (HP:0000640)1.73670442
164Vasculitis (HP:0002633)1.70805187
165Widely spaced teeth (HP:0000687)1.70638912
166Abnormality of the pleura (HP:0002103)1.69649016
167Abnormality of the prostate (HP:0008775)1.69618447
168Adactyly (HP:0009776)1.67724049
169Global brain atrophy (HP:0002283)1.67603230
170Frequent falls (HP:0002359)1.67361754
171Recurrent skin infections (HP:0001581)1.66927174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.01738871
2TGFBR25.16319885
3TIE15.08219944
4KDR3.75512709
5TTN2.97595993
6ADRBK22.41637302
7RIPK12.37345453
8ACVR1B2.34931536
9TRIB32.30969990
10ERN12.16956151
11CAMK1D2.11990521
12BMPR22.02471802
13GRK71.99862349
14WNK41.94216510
15PKN21.86370965
16DMPK1.84787646
17IRAK11.82000426
18TXK1.80553601
19MAP2K31.76888314
20BLK1.75345126
21TYK21.67847450
22MYLK1.64763356
23TEC1.62134420
24MAP4K21.57219182
25CAMK1G1.56817320
26PIK3CG1.52092480
27IKBKB1.45451472
28OBSCN1.39662636
29STK101.38323912
30BMPR1B1.35137571
31PTK61.32990597
32EPHB11.30239713
33PTK2B1.30082082
34TGFBR11.27884568
35KIT1.21184268
36MAPK121.19694456
37PDGFRA1.19059478
38INSRR1.18003077
39MAP3K141.17442409
40EPHA31.16156081
41WNK31.11963585
42PAK41.10278746
43JAK11.09832999
44MAPKAPK31.08360251
45CSK1.06629500
46NEK91.05298074
47TBK11.04268622
48IKBKE1.00840596
49FES1.00065148
50DAPK20.99544309
51PINK10.99193645
52MAP3K30.98786466
53JAK20.91815420
54MST1R0.90803633
55SYK0.90262732
56CAMK40.88582482
57IRAK30.88230641
58PDK20.88204229
59PRKAA20.84641855
60BCKDK0.83199479
61IRAK40.83138314
62PHKG20.82363842
63PHKG10.82363842
64OXSR10.82182560
65MAP3K70.81724352
66DDR20.81107140
67MAP2K60.80845274
68FGFR40.80662460
69FGR0.80281899
70CSF1R0.79591858
71PRKD10.79208388
72MAPK130.78980748
73PKN10.78564095
74SIK10.76473464
75CDC42BPA0.73834830
76PIK3CA0.72859332
77SGK30.72308562
78LYN0.71594875
79LMTK20.70310111
80NTRK30.69737851
81EPHB20.69124373
82WNK10.67726580
83CAMKK20.65728676
84LCK0.64721137
85BTK0.64688809
86MATK0.64264532
87BMX0.64058391
88LRRK20.64023555
89MAPK70.63463659
90GRK10.63354166
91CHUK0.62650249
92TAOK20.62298233
93ADRBK10.60124743
94PDPK10.59336156
95MAP3K100.58802716
96HCK0.57944377
97ITK0.57251323
98IRAK20.56239432
99JAK30.55970923
100EGFR0.55812176
101TSSK60.55429752
102PRKCH0.55305720
103MARK30.55150394
104CDK120.54696911
105PDK30.54230132
106PDK40.54230132
107MET0.53546248
108MAPKAPK50.53376326
109FGFR30.53358648
110PDK10.51310744
111MAP3K60.49700547
112ZAP700.49245004
113TNK20.48781389
114ERBB30.47556799
115IGF1R0.47325736
116SGK20.46862526
117GSK3A0.46815650
118FER0.46576396
119STK240.46479699
120PRKCE0.46063317
121PDGFRB0.45805756
122RIPK40.45492276
123STK380.45304281
124CLK10.44994965
125GRK50.44114352
126NLK0.44063252
127MAP3K40.43649318
128SCYL20.43459412
129MAP4K10.42828928
130PRKCQ0.42788541
131PTK20.41773671
132AKT30.41591092
133PRKG20.40871983
134MAP3K130.40010452
135MAP2K40.39365713
136ABL10.39225308
137MAP3K10.38124920
138TRPM70.37270831
139MOS0.37209637
140ICK0.37074812
141LATS10.36771569
142MAPK40.36177259
143MAP3K110.35829256
144CDK60.35530117
145TAOK30.35336217
146STK30.35265384
147TAOK10.34963112
148MAP2K10.32387951

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.26034101
2Asthma_Homo sapiens_hsa053102.29606170
3Graft-versus-host disease_Homo sapiens_hsa053322.18404373
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09757365
5Complement and coagulation cascades_Homo sapiens_hsa046102.07426167
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.07169239
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.06812624
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.04675356
9Allograft rejection_Homo sapiens_hsa053301.97827897
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95381429
11Dilated cardiomyopathy_Homo sapiens_hsa054141.92020247
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.84973054
13Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.81658232
14Fatty acid degradation_Homo sapiens_hsa000711.81578300
15Lysosome_Homo sapiens_hsa041421.76474307
16Other glycan degradation_Homo sapiens_hsa005111.74324867
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.73540673
18Propanoate metabolism_Homo sapiens_hsa006401.61473147
19Type I diabetes mellitus_Homo sapiens_hsa049401.61291161
20PPAR signaling pathway_Homo sapiens_hsa033201.59629621
21Autoimmune thyroid disease_Homo sapiens_hsa053201.56199563
22Hematopoietic cell lineage_Homo sapiens_hsa046401.53092496
23Nitrogen metabolism_Homo sapiens_hsa009101.48038743
24Focal adhesion_Homo sapiens_hsa045101.44624770
25ECM-receptor interaction_Homo sapiens_hsa045121.42477339
26Osteoclast differentiation_Homo sapiens_hsa043801.41261238
27Caffeine metabolism_Homo sapiens_hsa002321.39968729
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39164394
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34832351
30Leishmaniasis_Homo sapiens_hsa051401.33654644
31Fatty acid metabolism_Homo sapiens_hsa012121.33645347
32Pertussis_Homo sapiens_hsa051331.32252031
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27974731
34Adherens junction_Homo sapiens_hsa045201.25825864
35Arginine biosynthesis_Homo sapiens_hsa002201.24830479
36Amoebiasis_Homo sapiens_hsa051461.22412217
37Lysine degradation_Homo sapiens_hsa003101.20220094
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.19330845
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.18113030
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15819444
41Ether lipid metabolism_Homo sapiens_hsa005651.13287395
42Bile secretion_Homo sapiens_hsa049761.11692313
43Toxoplasmosis_Homo sapiens_hsa051451.11463865
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08674555
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08524664
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06807647
47Insulin resistance_Homo sapiens_hsa049311.05568712
48Viral myocarditis_Homo sapiens_hsa054161.04037703
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.03638045
50Malaria_Homo sapiens_hsa051441.02918821
51Tuberculosis_Homo sapiens_hsa051520.99818552
52Platelet activation_Homo sapiens_hsa046110.95550465
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95100571
54Tryptophan metabolism_Homo sapiens_hsa003800.94223436
55Measles_Homo sapiens_hsa051620.93198225
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92751346
57ABC transporters_Homo sapiens_hsa020100.91740376
58Linoleic acid metabolism_Homo sapiens_hsa005910.88839464
59Antigen processing and presentation_Homo sapiens_hsa046120.87612808
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85628252
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84878180
62Proteoglycans in cancer_Homo sapiens_hsa052050.84848517
63Phototransduction_Homo sapiens_hsa047440.84439520
64Carbon metabolism_Homo sapiens_hsa012000.83716062
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82495454
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82429419
67Salmonella infection_Homo sapiens_hsa051320.82268045
68Small cell lung cancer_Homo sapiens_hsa052220.80146143
69Phagosome_Homo sapiens_hsa041450.79889478
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78764008
71Sphingolipid metabolism_Homo sapiens_hsa006000.78658748
72Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78598922
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78383502
74Prion diseases_Homo sapiens_hsa050200.78170462
75Dorso-ventral axis formation_Homo sapiens_hsa043200.77480655
76B cell receptor signaling pathway_Homo sapiens_hsa046620.76190551
77Rap1 signaling pathway_Homo sapiens_hsa040150.75419315
78Starch and sucrose metabolism_Homo sapiens_hsa005000.75365509
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75071595
80Notch signaling pathway_Homo sapiens_hsa043300.75045937
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74904466
82Vitamin digestion and absorption_Homo sapiens_hsa049770.74886571
83Collecting duct acid secretion_Homo sapiens_hsa049660.74855508
84HIF-1 signaling pathway_Homo sapiens_hsa040660.72625574
85Renin-angiotensin system_Homo sapiens_hsa046140.70117570
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69025011
87Renin secretion_Homo sapiens_hsa049240.68897665
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66445939
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64879016
90beta-Alanine metabolism_Homo sapiens_hsa004100.64865628
91Mineral absorption_Homo sapiens_hsa049780.64292467
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.63893991
93Cardiac muscle contraction_Homo sapiens_hsa042600.63316893
94Arachidonic acid metabolism_Homo sapiens_hsa005900.62366260
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62075948
96Olfactory transduction_Homo sapiens_hsa047400.62011042
97African trypanosomiasis_Homo sapiens_hsa051430.61979381
98Peroxisome_Homo sapiens_hsa041460.61753937
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60189600
100Chemokine signaling pathway_Homo sapiens_hsa040620.59661495
101Morphine addiction_Homo sapiens_hsa050320.59587717
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59416496
103Salivary secretion_Homo sapiens_hsa049700.59291616
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55993101
105Herpes simplex infection_Homo sapiens_hsa051680.55909159
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55400155
107Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54802531
108Protein digestion and absorption_Homo sapiens_hsa049740.54147505
109Ovarian steroidogenesis_Homo sapiens_hsa049130.53906822
110Influenza A_Homo sapiens_hsa051640.53378707
111Butanoate metabolism_Homo sapiens_hsa006500.52585818
112Endocytosis_Homo sapiens_hsa041440.51796423
113Rheumatoid arthritis_Homo sapiens_hsa053230.51657422
114Legionellosis_Homo sapiens_hsa051340.48139403
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.47785693
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47473886
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47336140
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46792346
119Hepatitis C_Homo sapiens_hsa051600.45601865
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45327099
121VEGF signaling pathway_Homo sapiens_hsa043700.45069551
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44908725
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.44759716
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.44286179
125Type II diabetes mellitus_Homo sapiens_hsa049300.44066857
126Calcium signaling pathway_Homo sapiens_hsa040200.43881285
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43856764
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.43701080
129T cell receptor signaling pathway_Homo sapiens_hsa046600.42402837
130Selenocompound metabolism_Homo sapiens_hsa004500.42074013
131Pyruvate metabolism_Homo sapiens_hsa006200.41349166
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41318441
133Prolactin signaling pathway_Homo sapiens_hsa049170.41095172
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40978685
135Circadian entrainment_Homo sapiens_hsa047130.40320310
136Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39834766
137cAMP signaling pathway_Homo sapiens_hsa040240.39540936
138Glycerolipid metabolism_Homo sapiens_hsa005610.38233787
139Fatty acid biosynthesis_Homo sapiens_hsa000610.38215351
140Insulin signaling pathway_Homo sapiens_hsa049100.38131230
141Renal cell carcinoma_Homo sapiens_hsa052110.37729697
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.37446169
143TNF signaling pathway_Homo sapiens_hsa046680.36649815
144Oxytocin signaling pathway_Homo sapiens_hsa049210.36537251
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36459099
146Serotonergic synapse_Homo sapiens_hsa047260.36200684
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36066513
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.35980747
149Hepatitis B_Homo sapiens_hsa051610.34193886
150MAPK signaling pathway_Homo sapiens_hsa040100.33829045
151FoxO signaling pathway_Homo sapiens_hsa040680.33717269

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