STARD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by organism of defense response of other organism involved in symbiotic interact5.07699773
2modulation by symbiont of host immune response (GO:0052553)5.07699773
3positive regulation by symbiont of host defense response (GO:0052509)5.07699773
4modulation by symbiont of host defense response (GO:0052031)5.07699773
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.07699773
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.07699773
7regulation of interferon-beta biosynthetic process (GO:0045357)4.49500159
8interkinetic nuclear migration (GO:0022027)4.35134044
9macroautophagy (GO:0016236)4.23209478
10neutrophil mediated immunity (GO:0002446)4.22057409
11histone H3-K4 trimethylation (GO:0080182)4.12958637
12behavioral response to nicotine (GO:0035095)4.12373077
13negative regulation of cell killing (GO:0031342)3.99126439
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99126439
15negative regulation of granulocyte differentiation (GO:0030853)3.94878884
16macrophage activation involved in immune response (GO:0002281)3.94839170
17cilium or flagellum-dependent cell motility (GO:0001539)3.88324080
18microglial cell activation (GO:0001774)3.85009179
19positive regulation of cellular amide metabolic process (GO:0034250)3.74732827
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74606164
21natural killer cell mediated cytotoxicity (GO:0042267)3.74592326
22natural killer cell mediated immunity (GO:0002228)3.74592326
23I-kappaB phosphorylation (GO:0007252)3.71192079
24apoptotic cell clearance (GO:0043277)3.71156223
25germinal center formation (GO:0002467)3.68258323
26G-protein coupled receptor internalization (GO:0002031)3.57517970
27neutrophil activation involved in immune response (GO:0002283)3.56006658
28response to muramyl dipeptide (GO:0032495)3.54526994
29protein polyglutamylation (GO:0018095)3.48607131
30positive regulation of gamma-delta T cell activation (GO:0046645)3.41819613
31phospholipid homeostasis (GO:0055091)3.41588043
32negative regulation of interleukin-1 beta production (GO:0032691)3.34309328
33monoubiquitinated protein deubiquitination (GO:0035520)3.30422038
34establishment of protein localization to Golgi (GO:0072600)3.28664203
35membrane depolarization during action potential (GO:0086010)3.25888555
36response to host immune response (GO:0052572)3.25578649
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25578649
38negative regulation of cytosolic calcium ion concentration (GO:0051481)3.24844383
39regulation of integrin activation (GO:0033623)3.22388873
40cilium movement (GO:0003341)3.19536346
41sperm motility (GO:0030317)3.18804149
42regulation of hippo signaling (GO:0035330)3.17338125
43indole-containing compound catabolic process (GO:0042436)3.14380595
44indolalkylamine catabolic process (GO:0046218)3.14380595
45tryptophan catabolic process (GO:0006569)3.14380595
46acrosome reaction (GO:0007340)3.14015845
47central nervous system myelination (GO:0022010)3.13167705
48axon ensheathment in central nervous system (GO:0032291)3.13167705
49pinocytosis (GO:0006907)3.08279968
50myeloid leukocyte mediated immunity (GO:0002444)3.08275777
51positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.07945580
52nephron epithelium morphogenesis (GO:0072088)3.06340639
53nephron tubule morphogenesis (GO:0072078)3.06340639
54cell adhesion mediated by integrin (GO:0033627)3.02984900
55appendage development (GO:0048736)3.02473187
56limb development (GO:0060173)3.02473187
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02381391
58response to host (GO:0075136)3.02381391
59response to host defenses (GO:0052200)3.02381391
60modulation by symbiont of host cellular process (GO:0044068)3.02175822
61negative regulation of translation, ncRNA-mediated (GO:0040033)3.00251666
62regulation of translation, ncRNA-mediated (GO:0045974)3.00251666
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00251666
64mannose metabolic process (GO:0006013)3.00048012
65histone H3-K9 methylation (GO:0051567)2.98739046
66gamma-aminobutyric acid transport (GO:0015812)2.98637119
67epithelial cilium movement (GO:0003351)2.97530301
68kynurenine metabolic process (GO:0070189)2.97431312
69nucleus localization (GO:0051647)2.96850295
70B cell homeostasis (GO:0001782)2.96820532
71lipoprotein transport (GO:0042953)2.96659951
72regulation of ARF GTPase activity (GO:0032312)2.96524880
73early endosome to late endosome transport (GO:0045022)2.96440756
74protein kinase C signaling (GO:0070528)2.95833996
75indolalkylamine metabolic process (GO:0006586)2.95822589
76response to pheromone (GO:0019236)2.95514562
77negative regulation of interleukin-1 production (GO:0032692)2.94948639
78myeloid cell activation involved in immune response (GO:0002275)2.93826402
79membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93777298
80peptidyl-lysine trimethylation (GO:0018023)2.93078532
81positive regulation of B cell differentiation (GO:0045579)2.87838204
82negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.87405477
83Golgi to endosome transport (GO:0006895)2.86484456
84regulation of Cdc42 GTPase activity (GO:0043088)2.85810714
85regulation of gene silencing by RNA (GO:0060966)2.85414740
86regulation of posttranscriptional gene silencing (GO:0060147)2.85414740
87regulation of gene silencing by miRNA (GO:0060964)2.85414740
88cAMP catabolic process (GO:0006198)2.82896550
89cortical actin cytoskeleton organization (GO:0030866)2.80993075
90musculoskeletal movement (GO:0050881)2.80639655
91multicellular organismal movement (GO:0050879)2.80639655
92regulation of B cell receptor signaling pathway (GO:0050855)2.79023750
93cerebellar Purkinje cell differentiation (GO:0021702)2.78693227
94axoneme assembly (GO:0035082)2.78480036
95positive regulation of p38MAPK cascade (GO:1900745)2.76381110
96tryptophan metabolic process (GO:0006568)2.75096945
97cellular response to fluid shear stress (GO:0071498)2.72597245
98regulation of germinal center formation (GO:0002634)2.72534964
99urinary tract smooth muscle contraction (GO:0014848)2.72387150
100detection of light stimulus involved in sensory perception (GO:0050962)2.71712474
101detection of light stimulus involved in visual perception (GO:0050908)2.71712474
102antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71537856
103centriole replication (GO:0007099)2.70025865
104cyclic nucleotide catabolic process (GO:0009214)2.67912409
105developmental pigmentation (GO:0048066)2.66902687
106histone H3-K4 methylation (GO:0051568)2.66614544
107negative regulation of interleukin-6 production (GO:0032715)2.66313644
108positive thymic T cell selection (GO:0045059)2.65981148
109macrophage activation (GO:0042116)2.65892557
110negative regulation of lipid storage (GO:0010888)2.65651038
111negative regulation of Rho protein signal transduction (GO:0035024)2.65281607
112renal tubule morphogenesis (GO:0061333)2.63075561
113positive regulation of interleukin-1 beta secretion (GO:0050718)2.62873686
114positive regulation of developmental pigmentation (GO:0048087)2.62351335
115substrate-dependent cell migration (GO:0006929)2.61961613
116postsynaptic membrane organization (GO:0001941)2.60491829
117positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.59913344
118protein K48-linked deubiquitination (GO:0071108)2.57856448
119protein targeting to Golgi (GO:0000042)2.57505685
120retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55692053
121regulation of alkaline phosphatase activity (GO:0010692)2.54715244
122response to fluid shear stress (GO:0034405)2.54710208
123regulation of protein polyubiquitination (GO:1902914)2.54360032
124spinal cord motor neuron differentiation (GO:0021522)2.53940967
125monocyte differentiation (GO:0030224)2.53617311
126histone H3-K9 modification (GO:0061647)2.53163664
127neuronal action potential (GO:0019228)2.53009029
128NLS-bearing protein import into nucleus (GO:0006607)2.52297907
129positive regulation of cholesterol efflux (GO:0010875)2.51552252
130calcium ion-dependent exocytosis (GO:0017156)2.51205562
131neutrophil activation (GO:0042119)2.50558118
132cortical cytoskeleton organization (GO:0030865)2.50164191
133regulation of sarcomere organization (GO:0060297)2.48561588
134reflex (GO:0060004)2.48385056
135primary amino compound metabolic process (GO:1901160)2.48369369
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.46600181
137negative regulation of stress fiber assembly (GO:0051497)2.45553370
138microtubule polymerization or depolymerization (GO:0031109)2.44965421
139T cell mediated immunity (GO:0002456)2.43100661
140modification by symbiont of host morphology or physiology (GO:0044003)2.42652407
141cilium organization (GO:0044782)2.41418365
142neuromuscular synaptic transmission (GO:0007274)2.40730833
143neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.39949958
144detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39134841
145positive regulation of interleukin-1 secretion (GO:0050716)2.39124826
146wound healing, spreading of epidermal cells (GO:0035313)2.38650348
147positive regulation of interferon-alpha production (GO:0032727)2.38305477
148axonemal dynein complex assembly (GO:0070286)2.38088790
149regulation of mast cell activation involved in immune response (GO:0033006)2.38014863
150indole-containing compound metabolic process (GO:0042430)2.37165790
151positive regulation of CREB transcription factor activity (GO:0032793)2.36497064
152behavioral response to ethanol (GO:0048149)2.36299291
153regulation of mast cell degranulation (GO:0043304)2.35746849
154cilium assembly (GO:0042384)2.34975430
155regulation of pigment cell differentiation (GO:0050932)2.34647245
156transmission of nerve impulse (GO:0019226)2.34610444
157regulation of p38MAPK cascade (GO:1900744)2.34566077
158cellular response to ATP (GO:0071318)2.33404425
159negative regulation of astrocyte differentiation (GO:0048712)2.33038631
160negative regulation of macroautophagy (GO:0016242)2.32844146
161auditory behavior (GO:0031223)2.32591290
162histone lysine methylation (GO:0034968)2.32227391
163spinal cord development (GO:0021510)2.32044522
164leukocyte mediated cytotoxicity (GO:0001909)2.31988574
165regulation of Rab GTPase activity (GO:0032313)2.31412230
166positive regulation of Rab GTPase activity (GO:0032851)2.31412230
167semaphorin-plexin signaling pathway (GO:0071526)2.30538571
168filopodium assembly (GO:0046847)2.30384989
169phosphatidylglycerol biosynthetic process (GO:0006655)2.29684063
170cytoplasmic mRNA processing body assembly (GO:0033962)2.29580364
171microtubule severing (GO:0051013)2.29563919
172cytidine deamination (GO:0009972)2.29561499
173cytidine metabolic process (GO:0046087)2.29561499
174cytidine catabolic process (GO:0006216)2.29561499
175lysosome organization (GO:0007040)2.28704862
176serotonin metabolic process (GO:0042428)2.28343040
177cellular response to sterol (GO:0036315)2.28013544
178multicellular organism reproduction (GO:0032504)2.27606766
179head development (GO:0060322)2.27370978
180dendritic spine morphogenesis (GO:0060997)2.26391417
181central nervous system neuron axonogenesis (GO:0021955)2.25307233
182snRNA transcription (GO:0009301)2.25223527
183motile cilium assembly (GO:0044458)2.23822312
184peptidyl-lysine methylation (GO:0018022)2.23581104
185photoreceptor cell maintenance (GO:0045494)2.23345028
186lipid translocation (GO:0034204)2.22324741
187phospholipid translocation (GO:0045332)2.22324741
188regulation of non-canonical Wnt signaling pathway (GO:2000050)2.22284346
189peristalsis (GO:0030432)2.22215316
190retina layer formation (GO:0010842)2.21905259
191smooth muscle contraction (GO:0006939)2.20773138

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.90391093
2Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.60696059
3SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.20366296
4IRF8_27001747_Chip-Seq_BMDM_Mouse2.86698149
5VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.70813695
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.65091169
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.53121284
8SPI1_23127762_ChIP-Seq_K562_Human2.38936871
9VDR_22108803_ChIP-Seq_LS180_Human2.35030588
10SCL_19346495_ChIP-Seq_HPC-7_Human2.26775448
11GATA2_21666600_ChIP-Seq_HMVEC_Human2.23013394
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19844183
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.16745521
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.08777825
15ZNF274_21170338_ChIP-Seq_K562_Hela2.08601818
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.08361441
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06753808
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03053677
19VDR_24787735_ChIP-Seq_THP-1_Human1.98039515
20PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.86217957
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84577135
22DROSHA_22980978_ChIP-Seq_HELA_Human1.82723748
23FUS_26573619_Chip-Seq_HEK293_Human1.82513202
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.81506689
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79922487
26AR_21572438_ChIP-Seq_LNCaP_Human1.79309112
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.71438643
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70286291
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.68903359
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68474977
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66610056
32TAF15_26573619_Chip-Seq_HEK293_Human1.65459177
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.64931357
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63589477
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61789508
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.61000505
37P300_19829295_ChIP-Seq_ESCs_Human1.60334263
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.53944179
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.52325884
40NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51509626
41ER_23166858_ChIP-Seq_MCF-7_Human1.50227970
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50049366
43CBP_20019798_ChIP-Seq_JUKART_Human1.49929668
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49929668
45JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49219960
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49047184
47IGF1R_20145208_ChIP-Seq_DFB_Human1.48852689
48NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48593223
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48012891
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.46781977
51TP53_16413492_ChIP-PET_HCT116_Human1.46283470
52ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45947271
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45142478
54AHR_22903824_ChIP-Seq_MCF-7_Human1.44982740
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.44375327
56GBX2_23144817_ChIP-Seq_PC3_Human1.44014575
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43898278
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.43256652
59REST_21632747_ChIP-Seq_MESCs_Mouse1.43078331
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41099999
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40309531
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.40087100
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38598618
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38507674
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.36676450
66AR_25329375_ChIP-Seq_VCAP_Human1.35715572
67PU_27001747_Chip-Seq_BMDM_Mouse1.35362466
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34178336
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34009924
70BCAT_22108803_ChIP-Seq_LS180_Human1.33725700
71EWS_26573619_Chip-Seq_HEK293_Human1.33361978
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.32942235
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31728753
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31464475
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29789376
76VDR_24763502_ChIP-Seq_THP-1_Human1.28257889
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27481116
78RUNX2_22187159_ChIP-Seq_PCA_Human1.27339503
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.26782070
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.24869201
81SOX2_21211035_ChIP-Seq_LN229_Gbm1.24748630
82RUNX_20019798_ChIP-Seq_JUKART_Human1.24551644
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23122184
84RNF2_27304074_Chip-Seq_ESCs_Mouse1.22668456
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22139918
86TCF7_22412390_ChIP-Seq_EML_Mouse1.21232933
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.20743751
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20539560
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.19657546
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.19145556
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18835906
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18494451
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18270204
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18026424
95EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17102090
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17042935
97FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16625729
98RNF2_27304074_Chip-Seq_NSC_Mouse1.16260703
99EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15889922
100RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15889922
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.15767630
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14937233
103AR_19668381_ChIP-Seq_PC3_Human1.14581670
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14455009
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13161388
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.12754066
107BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11939035
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11682267
109KDM2B_26808549_Chip-Seq_REH_Human1.11381986
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.11008025
111EP300_21415370_ChIP-Seq_HL-1_Mouse1.10978224
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10522570
113RXR_22108803_ChIP-Seq_LS180_Human1.10177221
114SMAD4_21741376_ChIP-Seq_HESCs_Human1.09704378
115WDR5_24793694_ChIP-Seq_LNCAP_Human1.07925731
116VDR_21846776_ChIP-Seq_THP-1_Human1.07425485
117SMAD3_21741376_ChIP-Seq_ESCs_Human1.06592850
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06097466
119OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05981422
120MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05755045
121KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05592186
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05310737
123SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05310382
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.05148343
125PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04730339
126TP63_19390658_ChIP-ChIP_HaCaT_Human1.03862791
127TCF4_22108803_ChIP-Seq_LS180_Human1.03530104
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03442910
129PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03301613
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.02418315
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02340000
132STAT3_23295773_ChIP-Seq_U87_Human1.02246113
133HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02061312
134BRD4_25478319_ChIP-Seq_HGPS_Human1.01936091
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01643399
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01469319
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01086069
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00551318
139TBX20_22080862_ChIP-Seq_HEART_Mouse1.00437057
140TBX20_22328084_ChIP-Seq_HEART_Mouse1.00437057
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99694540
142TCF4_23295773_ChIP-Seq_U87_Human0.99565459
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99016175
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98492463
145PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97804505
146NANOG_18555785_Chip-Seq_ESCs_Mouse0.97798961
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.97641524
148CJUN_26792858_Chip-Seq_BT549_Human0.96619135
149MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96410645
150GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96354461
151SMAD3_21741376_ChIP-Seq_HESCs_Human0.94427171
152EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94061022
153E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93651348
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93308478
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93308478
156FOXM1_23109430_ChIP-Seq_U2OS_Human0.92173002
157CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90037645
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89612933
159* KDM2B_26808549_Chip-Seq_DND41_Human0.89402516
160GATA1_19941826_ChIP-Seq_K562_Human0.89139670
161GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89137318
162PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.89080125
163GATA2_19941826_ChIP-Seq_K562_Human0.88733630
164MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88711992
165STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86052637
166GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83807253
167SMAD4_21799915_ChIP-Seq_A2780_Human0.83004428
168JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82828982
169ISL1_27105846_Chip-Seq_CPCs_Mouse0.82093704
170KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81505450
171ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80710639
172KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80701737

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005174_abnormal_tail_pigmentation3.95066269
2MP0003172_abnormal_lysosome_physiology3.93128897
3MP0000015_abnormal_ear_pigmentation3.59741188
4MP0005058_abnormal_lysosome_morphology3.48763729
5MP0009278_abnormal_bone_marrow3.08242412
6MP0003183_abnormal_peptide_metabolism2.42648816
7MP0004510_myositis2.39097079
8MP0005377_hearing/vestibular/ear_phenot2.32658690
9MP0003878_abnormal_ear_physiology2.32658690
10MP0001958_emphysema2.31972009
11MP0003646_muscle_fatigue2.29378039
12MP0003136_yellow_coat_color2.28097338
13MP0002638_abnormal_pupillary_reflex2.21502354
14MP0000371_diluted_coat_color2.11476326
15MP0001486_abnormal_startle_reflex2.09415003
16MP0001501_abnormal_sleep_pattern2.08094959
17MP0005551_abnormal_eye_electrophysiolog2.06787235
18MP0000569_abnormal_digit_pigmentation11.3152150
19MP0003045_fibrosis1.98629468
20MP0005646_abnormal_pituitary_gland1.91995200
21MP0001485_abnormal_pinna_reflex1.87060359
22MP0008438_abnormal_cutaneous_collagen1.87037439
23MP0003300_gastrointestinal_ulcer1.84711131
24MP0005167_abnormal_blood-brain_barrier1.83324447
25MP0001984_abnormal_olfaction1.79569372
26MP0005464_abnormal_platelet_physiology1.79521120
27MP0002735_abnormal_chemical_nociception1.76273231
28MP0002166_altered_tumor_susceptibility1.73519778
29MP0001968_abnormal_touch/_nociception1.73328781
30MP0002419_abnormal_innate_immunity1.71599265
31MP0009745_abnormal_behavioral_response1.71401859
32MP0002272_abnormal_nervous_system1.66151939
33MP0001835_abnormal_antigen_presentation1.61861587
34MP0005670_abnormal_white_adipose1.60994955
35MP0003566_abnormal_cell_adhesion1.56952943
36MP0003635_abnormal_synaptic_transmissio1.53703527
37MP0004142_abnormal_muscle_tone1.49401473
38MP0005423_abnormal_somatic_nervous1.49333123
39MP0002064_seizures1.48685803
40MP0000778_abnormal_nervous_system1.48520414
41MP0005257_abnormal_intraocular_pressure1.48476930
42MP0002396_abnormal_hematopoietic_system1.47806754
43MP0002572_abnormal_emotion/affect_behav1.45593840
44MP0002067_abnormal_sensory_capabilities1.43335696
45MP0002557_abnormal_social/conspecific_i1.42244503
46MP0004885_abnormal_endolymph1.41939085
47MP0003690_abnormal_glial_cell1.41392445
48MP0000631_abnormal_neuroendocrine_gland1.40209601
49MP0006276_abnormal_autonomic_nervous1.38729303
50MP0005503_abnormal_tendon_morphology1.35455195
51MP0004215_abnormal_myocardial_fiber1.35328518
52MP0002063_abnormal_learning/memory/cond1.35208390
53MP0003091_abnormal_cell_migration1.34924704
54MP0002733_abnormal_thermal_nociception1.34316641
55MP0004043_abnormal_pH_regulation1.34149950
56MP0008057_abnormal_DNA_replication1.34048450
57MP0010386_abnormal_urinary_bladder1.33444461
58MP0005645_abnormal_hypothalamus_physiol1.33427221
59MP0004859_abnormal_synaptic_plasticity1.31250752
60MP0002734_abnormal_mechanical_nocicepti1.29018209
61MP0003303_peritoneal_inflammation1.28477341
62MP0003698_abnormal_male_reproductive1.27918283
63MP0005253_abnormal_eye_physiology1.24696539
64MP0001970_abnormal_pain_threshold1.23660866
65MP0008877_abnormal_DNA_methylation1.23463179
66MP0006292_abnormal_olfactory_placode1.23348008
67MP0005076_abnormal_cell_differentiation1.22966445
68MP0001545_abnormal_hematopoietic_system1.22168207
69MP0005397_hematopoietic_system_phenotyp1.22168207
70MP0003279_aneurysm1.21891975
71MP0002653_abnormal_ependyma_morphology1.20561615
72MP0006082_CNS_inflammation1.19503308
73MP0010307_abnormal_tumor_latency1.18495625
74MP0008961_abnormal_basal_metabolism1.18008942
75MP0004381_abnormal_hair_follicle1.16203090
76MP0000767_abnormal_smooth_muscle1.15591328
77MP0002452_abnormal_antigen_presenting1.15490179
78MP0002928_abnormal_bile_duct1.15469063
79MP0001963_abnormal_hearing_physiology1.15202573
80MP0001851_eye_inflammation1.13957088
81MP0005075_abnormal_melanosome_morpholog1.13526088
82MP0000026_abnormal_inner_ear1.13329848
83MP0002006_tumorigenesis1.11725564
84MP0001986_abnormal_taste_sensitivity1.11256982
85MP0000955_abnormal_spinal_cord1.11041608
86MP0003828_pulmonary_edema1.10934716
87MP0005410_abnormal_fertilization1.10476355
88MP0002249_abnormal_larynx_morphology1.08722183
89MP0010368_abnormal_lymphatic_system1.06787565
90MP0003880_abnormal_central_pattern1.06751929
91MP0002184_abnormal_innervation1.06299372
92MP0002095_abnormal_skin_pigmentation1.05694436
93MP0000733_abnormal_muscle_development1.05183575
94MP0009046_muscle_twitch1.04968041
95MP0000751_myopathy1.03904665
96MP0001348_abnormal_lacrimal_gland1.03482752
97MP0001800_abnormal_humoral_immune1.03424333
98MP0005386_behavior/neurological_phenoty1.02625134
99MP0004924_abnormal_behavior1.02625134
100MP0001270_distended_abdomen1.02331299
101MP0001879_abnormal_lymphatic_vessel1.01804244
102MP0001502_abnormal_circadian_rhythm1.01150886
103MP0003191_abnormal_cellular_cholesterol1.00993186
104MP0002723_abnormal_immune_serum1.00617828
105MP0002075_abnormal_coat/hair_pigmentati1.00157001
106MP0008260_abnormal_autophagy0.99726769
107MP0003705_abnormal_hypodermis_morpholog0.99007732
108MP0003195_calcinosis0.99002108
109MP0008872_abnormal_physiological_respon0.98698859
110MP0000230_abnormal_systemic_arterial0.98262987
111MP0004130_abnormal_muscle_cell0.97925281
112MP0002938_white_spotting0.97787971
113MP0004272_abnormal_basement_membrane0.97152984
114MP0002876_abnormal_thyroid_physiology0.96965007
115MP0005409_darkened_coat_color0.96636364
116MP0002882_abnormal_neuron_morphology0.96559474
117MP0002752_abnormal_somatic_nervous0.96546323
118MP0003879_abnormal_hair_cell0.96493497
119MP0008775_abnormal_heart_ventricle0.96291702
120MP0009115_abnormal_fat_cell0.95347484
121MP0004085_abnormal_heartbeat0.93845001
122MP0001929_abnormal_gametogenesis0.93666667
123MP0002168_other_aberrant_phenotype0.92985255
124MP0000427_abnormal_hair_cycle0.92679288
125MP0002837_dystrophic_cardiac_calcinosis0.92541088
126MP0003787_abnormal_imprinting0.91834629
127MP0008995_early_reproductive_senescence0.90916913
128MP0000534_abnormal_ureter_morphology0.90407158
129MP0002998_abnormal_bone_remodeling0.90013382
130MP0002822_catalepsy0.89857333
131MP0001873_stomach_inflammation0.89574496
132MP0004947_skin_inflammation0.89513422
133MP0003632_abnormal_nervous_system0.88894107
134MP0002102_abnormal_ear_morphology0.88607300
135MP0000013_abnormal_adipose_tissue0.88313473
136MP0003448_altered_tumor_morphology0.87781723
137MP0003634_abnormal_glial_cell0.87481440
138MP0000049_abnormal_middle_ear0.86612018
139MP0003436_decreased_susceptibility_to0.85906682
140MP0005387_immune_system_phenotype0.85346188
141MP0001790_abnormal_immune_system0.85346188
142MP0002229_neurodegeneration0.85098309
143MP0003950_abnormal_plasma_membrane0.84469221
144MP0001819_abnormal_immune_cell0.84076825
145MP0003283_abnormal_digestive_organ0.83866186
146MP0001440_abnormal_grooming_behavior0.83440575
147MP0005025_abnormal_response_to0.83125576
148MP0002420_abnormal_adaptive_immunity0.81782399
149MP0000685_abnormal_immune_system0.78771102
150MP0005000_abnormal_immune_tolerance0.77754327
151MP0000920_abnormal_myelination0.77486527
152MP0001324_abnormal_eye_pigmentation0.76657954
153MP0000465_gastrointestinal_hemorrhage0.75462833
154MP0005171_absent_coat_pigmentation0.75341783
155MP0002332_abnormal_exercise_endurance0.75118575
156MP0001915_intracranial_hemorrhage0.74964939
157MP0004808_abnormal_hematopoietic_stem0.74826221
158MP0010630_abnormal_cardiac_muscle0.74632135
159MP0005197_abnormal_uvea_morphology0.71021092
160MP0005623_abnormal_meninges_morphology0.68744324
161MP0000383_abnormal_hair_follicle0.68360260
162MP0001533_abnormal_skeleton_physiology0.68157619
163MP0002405_respiratory_system_inflammati0.67695778
164MP0004742_abnormal_vestibular_system0.66133065
165MP0005666_abnormal_adipose_tissue0.64650396
166MP0000249_abnormal_blood_vessel0.63735606
167MP0004145_abnormal_muscle_electrophysio0.62013147
168MP0005408_hypopigmentation0.59691515
169MP0000689_abnormal_spleen_morphology0.59454655
170MP0000604_amyloidosis0.59409142
171MP0005671_abnormal_response_to0.58765595
172MP0001186_pigmentation_phenotype0.58126296
173MP0000749_muscle_degeneration0.58017446
174MP0003633_abnormal_nervous_system0.55171195
175MP0001243_abnormal_dermal_layer0.54499506
176MP0002060_abnormal_skin_morphology0.53978937
177MP0009763_increased_sensitivity_to0.53916951
178MP0002108_abnormal_muscle_morphology0.53397848
179MP0002925_abnormal_cardiovascular_devel0.53154661
180MP0004084_abnormal_cardiac_muscle0.52451585

Predicted human phenotypes

RankGene SetZ-score
1Genetic anticipation (HP:0003743)5.22564677
2Recurrent bacterial skin infections (HP:0005406)4.52080928
3Recurrent abscess formation (HP:0002722)4.40206028
4Progressive cerebellar ataxia (HP:0002073)4.35028613
5Urethral obstruction (HP:0000796)3.86404453
6Chronic hepatic failure (HP:0100626)3.77439258
7Hyperventilation (HP:0002883)3.71653091
8Cerebral aneurysm (HP:0004944)3.66387266
9Gaze-evoked nystagmus (HP:0000640)3.46749606
10Hematochezia (HP:0002573)3.38042010
11Pancreatic cysts (HP:0001737)3.37993500
12Absent frontal sinuses (HP:0002688)3.28063499
13Nephronophthisis (HP:0000090)3.27730058
14Pancreatic fibrosis (HP:0100732)3.23614600
15Periodontitis (HP:0000704)3.15348172
16Abnormality of the renal medulla (HP:0100957)3.10488162
17Distal lower limb amyotrophy (HP:0008944)2.99989409
18Submucous cleft hard palate (HP:0000176)2.99116476
19Gingivitis (HP:0000230)2.94875206
20Abnormality of the fingertips (HP:0001211)2.93456824
21Pulmonary artery stenosis (HP:0004415)2.93160379
22Prostate neoplasm (HP:0100787)2.88876942
23Tubular atrophy (HP:0000092)2.86492159
24Disinhibition (HP:0000734)2.85838812
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.84259347
26Cystic liver disease (HP:0006706)2.83283006
27Increased cerebral lipofuscin (HP:0011813)2.81961089
28Molar tooth sign on MRI (HP:0002419)2.81323983
29Abnormality of midbrain morphology (HP:0002418)2.81323983
30True hermaphroditism (HP:0010459)2.80771453
31Protruding tongue (HP:0010808)2.78282586
32Abnormality of the renal cortex (HP:0011035)2.72621359
33Thick nail (HP:0001805)2.71004479
34Abnormality of glycolipid metabolism (HP:0010969)2.66701629
35Abnormality of liposaccharide metabolism (HP:0010968)2.66701629
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.66701629
37Heterotopia (HP:0002282)2.64177780
38Febrile seizures (HP:0002373)2.61190493
39Tubulointerstitial nephritis (HP:0001970)2.57869436
40Attenuation of retinal blood vessels (HP:0007843)2.57542890
41Macroorchidism (HP:0000053)2.55303910
42Lower limb amyotrophy (HP:0007210)2.55014858
43Mitral valve prolapse (HP:0001634)2.52284758
44Short 4th metacarpal (HP:0010044)2.52181104
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52181104
46Large earlobe (HP:0009748)2.51196573
47Congenital stationary night blindness (HP:0007642)2.50569838
48Polydipsia (HP:0001959)2.49863389
49Abnormal drinking behavior (HP:0030082)2.49863389
50Broad-based gait (HP:0002136)2.49766383
51Narrow palate (HP:0000189)2.49447558
52Recurrent skin infections (HP:0001581)2.48753050
53Abnormal ciliary motility (HP:0012262)2.48430126
54Truncal obesity (HP:0001956)2.46577107
55Stomatitis (HP:0010280)2.40118382
56Ocular albinism (HP:0001107)2.39041231
57Abnormality of the renal collecting system (HP:0004742)2.38793583
58Absent/shortened dynein arms (HP:0200106)2.37334287
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.37334287
60Systemic lupus erythematosus (HP:0002725)2.36632050
61Abnormality of the pubic bones (HP:0003172)2.36100907
62Axonal loss (HP:0003447)2.33493901
63Onion bulb formation (HP:0003383)2.33008860
64Peripheral demyelination (HP:0011096)2.32270668
65Amyloidosis (HP:0011034)2.31115818
66Slow saccadic eye movements (HP:0000514)2.29690739
67Hyperkalemia (HP:0002153)2.29332539
68Eczematoid dermatitis (HP:0000976)2.29066956
69Generalized hypopigmentation (HP:0007513)2.28731097
70Premature loss of primary teeth (HP:0006323)2.27063530
71Intestinal fistula (HP:0100819)2.25720086
72Focal seizures (HP:0007359)2.25618188
73Upper limb muscle weakness (HP:0003484)2.25484984
74Clumsiness (HP:0002312)2.25347282
75Elevated erythrocyte sedimentation rate (HP:0003565)2.24836239
76Colitis (HP:0002583)2.23558231
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.23464507
78Bony spicule pigmentary retinopathy (HP:0007737)2.22863857
79Hypoplastic ischia (HP:0003175)2.19845374
80Increased CSF protein (HP:0002922)2.18939303
81Cutaneous finger syndactyly (HP:0010554)2.18643688
82Aortic aneurysm (HP:0004942)2.17613725
83Autoimmune thrombocytopenia (HP:0001973)2.16970932
84Duplicated collecting system (HP:0000081)2.16079824
85Distal lower limb muscle weakness (HP:0009053)2.15996064
86Tubulointerstitial abnormality (HP:0001969)2.15822976
87Absent speech (HP:0001344)2.14207845
88Osteolytic defects of the hand bones (HP:0009699)2.11995366
89Osteolytic defects of the phalanges of the hand (HP:0009771)2.11995366
90Pathologic fracture (HP:0002756)2.11647404
91Congenital hepatic fibrosis (HP:0002612)2.11610657
92Increased corneal curvature (HP:0100692)2.10713659
93Keratoconus (HP:0000563)2.10713659
94Neoplasm of the heart (HP:0100544)2.10489454
95Bulbous nose (HP:0000414)2.08557355
96Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.07802019
97Abnormality of the frontal sinuses (HP:0002687)2.07003444
98Ectopic kidney (HP:0000086)2.06527415
99Chromosomal breakage induced by crosslinking agents (HP:0003221)2.06354993
100Hemiparesis (HP:0001269)2.04748527
101Action tremor (HP:0002345)2.04595275
102Neurodegeneration (HP:0002180)2.04551283
103Disproportionate tall stature (HP:0001519)2.03609110
104Medial flaring of the eyebrow (HP:0010747)2.03534282
105Decreased circulating renin level (HP:0003351)2.03087350
106Abnormality of the nasal septum (HP:0000419)2.02654505
107Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99770713
108Glomerulonephritis (HP:0000099)1.99729188
109Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.98080189
110Abnormality of macrophages (HP:0004311)1.96847619
111Abnormality of the 4th metacarpal (HP:0010012)1.96665598
112Upper motor neuron abnormality (HP:0002127)1.96630484
113Abnormality of the ischium (HP:0003174)1.96452868
114Polyuria (HP:0000103)1.96049706
115Mask-like facies (HP:0000298)1.95081609
116Cerebellar dysplasia (HP:0007033)1.94634091
117Segmental peripheral demyelination/remyelination (HP:0003481)1.93875227
118Abnormality of the thoracic spine (HP:0100711)1.92685034
119Frequent falls (HP:0002359)1.92670463
120Impaired smooth pursuit (HP:0007772)1.92643755
121Abnormal respiratory motile cilium physiology (HP:0012261)1.92640558
122Global brain atrophy (HP:0002283)1.92462163
123Intellectual disability, moderate (HP:0002342)1.92145415
124Abnormal respiratory epithelium morphology (HP:0012253)1.91859908
125Abnormal respiratory motile cilium morphology (HP:0005938)1.91859908
126Bruising susceptibility (HP:0000978)1.90193632
127Neuronal loss in central nervous system (HP:0002529)1.90120477
128Renovascular hypertension (HP:0100817)1.89719578
129Aplasia/Hypoplasia of the tibia (HP:0005772)1.89675518
130Broad metatarsal (HP:0001783)1.89548154
131Striae distensae (HP:0001065)1.89367752
132Abnormality of binocular vision (HP:0011514)1.89116118
133Diplopia (HP:0000651)1.89116118
134Recurrent gram-negative bacterial infections (HP:0005420)1.88794538
135Iris hypopigmentation (HP:0007730)1.88426277
136Atonic seizures (HP:0010819)1.88267930
137Tented upper lip vermilion (HP:0010804)1.87952922
138Progressive sensorineural hearing impairment (HP:0000408)1.87871725
139Genital tract atresia (HP:0001827)1.87633841
140Inappropriate behavior (HP:0000719)1.87441102
141Long toe (HP:0010511)1.86883368
142Drooling (HP:0002307)1.86763333
143Facial shape deformation (HP:0011334)1.86039658
144Potter facies (HP:0002009)1.86039658
145Tetany (HP:0001281)1.85660107
146Highly arched eyebrow (HP:0002553)1.85528235
147Fair hair (HP:0002286)1.85313465
148Abnormality of the columella (HP:0009929)1.84957371
149Large for gestational age (HP:0001520)1.84897899
150Thoracic kyphosis (HP:0002942)1.84716969
151Type II lissencephaly (HP:0007260)1.83888891
152Vaginal atresia (HP:0000148)1.83875928
153Chromsome breakage (HP:0040012)1.83604025
154Hemiplegia (HP:0002301)1.83500963
155Anal stenosis (HP:0002025)1.82710640
156Abnormality of the sella turcica (HP:0002679)1.82585842
157Decreased central vision (HP:0007663)1.82163859
158Gingival bleeding (HP:0000225)1.81795481
159Ulnar claw (HP:0001178)1.81158960
160Prolonged QT interval (HP:0001657)1.81061925
161Anophthalmia (HP:0000528)1.80209678
162Progressive hearing impairment (HP:0001730)1.79805469
163Decreased motor nerve conduction velocity (HP:0003431)1.79777363
164Arterial tortuosity (HP:0005116)1.79602862
165Bell-shaped thorax (HP:0001591)1.79290467
166Depressed nasal tip (HP:0000437)1.79217610
167Poor coordination (HP:0002370)1.79196219
168Bone pain (HP:0002653)1.78858920
169Foot dorsiflexor weakness (HP:0009027)1.76744295
170Recurrent fungal infections (HP:0002841)1.76324559
171J-shaped sella turcica (HP:0002680)1.76000530
172Cutaneous syndactyly (HP:0012725)1.75367011
173Epileptic encephalopathy (HP:0200134)1.75239945
174Deformed sella turcica (HP:0002681)1.74881558
175Sclerocornea (HP:0000647)1.74624905
176Stomach cancer (HP:0012126)1.74267250
177Turricephaly (HP:0000262)1.73605645
178Abnormality of vision evoked potentials (HP:0000649)1.73561084
179Postaxial foot polydactyly (HP:0001830)1.72784118
180Impulsivity (HP:0100710)1.72300510
181Focal motor seizures (HP:0011153)1.72168107
182Dialeptic seizures (HP:0011146)1.71775494
183Midline defect of the nose (HP:0004122)1.71589112
184Increased connective tissue (HP:0009025)1.71586358
185Widely spaced teeth (HP:0000687)1.70851480
186Patellar aplasia (HP:0006443)1.70582430
187Gait imbalance (HP:0002141)1.70494028
188Blue irides (HP:0000635)1.69008074
189Hypoplastic iliac wings (HP:0002866)1.68660690
190Abnormal pancreas size (HP:0012094)1.67096178
191Morphological abnormality of the middle ear (HP:0008609)1.66982316
192Partial agenesis of the corpus callosum (HP:0001338)1.66946472
193Abnormal urine output (HP:0012590)1.66791679
194Abnormality of the aortic arch (HP:0012303)1.65264916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.72949890
2CAMK1G4.07346987
3CAMK1D3.97682523
4RIPK43.07671121
5CDK123.00065840
6TGFBR22.99081182
7TTN2.78361451
8BMPR1B2.74531384
9SIK22.71110557
10KIT2.44547245
11RIPK12.18234159
12TAOK32.14885707
13ICK2.11651234
14ACVR1B2.00757042
15MAP3K141.91833517
16DAPK21.82723865
17AKT31.74986675
18PTK61.73626832
19BRD41.72501301
20ADRBK21.69377120
21WNK41.68196618
22CASK1.67958654
23TYK21.65726356
24CSF1R1.64541185
25MAP3K131.59378330
26NTRK31.59099143
27MAP4K21.58998517
28FES1.58097005
29GRK11.54074168
30MARK11.52007658
31MAPK131.51251821
32HCK1.48940672
33IRAK31.47669610
34NUAK11.47214925
35FGFR21.47164081
36IRAK41.41876447
37MAP3K41.41296484
38MKNK21.40376939
39PTK2B1.38823132
40WNK11.32776811
41JAK11.31313693
42LATS11.31055117
43PKN11.26026287
44CDK61.23889881
45NTRK21.21852254
46TNIK1.19797595
47PDGFRB1.19209337
48PLK41.17312232
49TYRO31.14728267
50SGK21.11937939
51MTOR1.10863736
52CLK11.07839387
53MAPK71.07083302
54STK38L1.07079930
55TBK11.07018852
56MAPK121.05805187
57STK391.05385330
58EPHB11.05232044
59SGK31.04594173
60PINK11.04341945
61PIK3CG1.03913326
62FGR1.02605770
63BRSK21.02525050
64ZAP700.99977112
65NLK0.98885412
66TGFBR10.98354017
67ZAK0.97264940
68INSRR0.97139208
69IKBKB0.96122184
70CAMK40.94118211
71PNCK0.93778950
72DDR20.93602816
73OBSCN0.93371043
74CHUK0.91261971
75TIE10.88297260
76YES10.87876671
77WNK30.85629032
78CSK0.84680470
79SGK10.82203190
80EGFR0.81458503
81PRKAA20.81056747
82TRPM70.80761195
83LCK0.79927571
84GRK70.79474170
85IKBKE0.78521709
86NEK20.77900400
87TRIB30.75347270
88MARK20.73630845
89MAP4K10.73398521
90STK380.72390418
91MELK0.72326628
92ERBB20.72288174
93MAP2K30.70978722
94MAPK100.70098111
95PDPK10.70005393
96STK110.69208093
97DMPK0.68477987
98PDK10.67723813
99PIK3CA0.67254262
100PAK20.67180985
101SGK2230.66652891
102SGK4940.66652891
103EEF2K0.66328930
104TEC0.65017268
105PTK20.64856526
106STK30.64790271
107JAK30.64458518
108ADRBK10.63275859
109PDGFRA0.61712524
110PRKCE0.60675865
111MAPK150.59909756
112CAMKK20.59861449
113MAPK110.59107903
114CDC42BPA0.58447896
115NEK90.58050191
116PLK20.57814086
117EPHA40.57782767
118PAK40.57634294
119PRKCG0.56824272
120PAK30.55115916
121PRPF4B0.54284393
122RPS6KA60.53680752
123PRKG10.53522185
124OXSR10.53311647
125CDK30.51778830
126MAP3K70.51739953
127JAK20.51015343
128DYRK1A0.51012707
129FYN0.50755307
130PRKCH0.50163672
131STK40.49733778
132PRKD10.48702918
133GSK3B0.48575339
134SRC0.48449644
135MAPK10.47838060
136ABL10.46806460
137ITK0.46537072
138MARK30.45343090
139CDK90.44693331
140INSR0.44238498
141CAMK10.43715406
142MKNK10.43650385
143ATR0.43614546
144GSK3A0.43614481
145CAMK2A0.43540490
146RPS6KA20.43107994
147RPS6KA30.42916155
148MAPK80.42871013
149TLK10.42564021
150MAPKAPK50.41404092
151LYN0.41013712
152TNK20.40711742
153WEE10.40297268
154CSNK1D0.40048133
155SYK0.38934733
156PRKAA10.38313455
157UHMK10.38150326
158CAMKK10.36415986
159IGF1R0.35589535
160SIK10.35165784
161PRKDC0.34110984

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.78663977
2Taste transduction_Homo sapiens_hsa047422.25222451
3Morphine addiction_Homo sapiens_hsa050322.15654303
4Osteoclast differentiation_Homo sapiens_hsa043802.11930227
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.11688991
6Circadian entrainment_Homo sapiens_hsa047132.05085031
7Phototransduction_Homo sapiens_hsa047442.03718167
8Lysine degradation_Homo sapiens_hsa003102.03190801
9Glutamatergic synapse_Homo sapiens_hsa047241.98872742
10B cell receptor signaling pathway_Homo sapiens_hsa046621.89515684
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86040025
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83458099
13Caffeine metabolism_Homo sapiens_hsa002321.80776048
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78277766
15Type II diabetes mellitus_Homo sapiens_hsa049301.73949395
16Olfactory transduction_Homo sapiens_hsa047401.73404321
17Staphylococcus aureus infection_Homo sapiens_hsa051501.68984762
18GABAergic synapse_Homo sapiens_hsa047271.67974987
19Insulin secretion_Homo sapiens_hsa049111.65994947
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62417661
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.59051518
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55201773
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53236456
24Salivary secretion_Homo sapiens_hsa049701.52252299
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51112730
26Butanoate metabolism_Homo sapiens_hsa006501.48454181
27Cholinergic synapse_Homo sapiens_hsa047251.46806372
28Nitrogen metabolism_Homo sapiens_hsa009101.46471127
29Lysosome_Homo sapiens_hsa041421.45990497
30Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.45543511
31Other glycan degradation_Homo sapiens_hsa005111.44038446
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42828528
33Linoleic acid metabolism_Homo sapiens_hsa005911.41635358
34Leishmaniasis_Homo sapiens_hsa051401.39175940
35Dorso-ventral axis formation_Homo sapiens_hsa043201.35727055
36Chronic myeloid leukemia_Homo sapiens_hsa052201.35149895
37Oxytocin signaling pathway_Homo sapiens_hsa049211.35044147
38Tryptophan metabolism_Homo sapiens_hsa003801.33065269
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.32533118
40Serotonergic synapse_Homo sapiens_hsa047261.30035158
41Malaria_Homo sapiens_hsa051441.27676216
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27175088
43Tuberculosis_Homo sapiens_hsa051521.26031722
44Fatty acid biosynthesis_Homo sapiens_hsa000611.25867154
45Toxoplasmosis_Homo sapiens_hsa051451.23371023
46Fanconi anemia pathway_Homo sapiens_hsa034601.21237209
47Inositol phosphate metabolism_Homo sapiens_hsa005621.19263996
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17390639
49Pertussis_Homo sapiens_hsa051331.17245103
50Glycerolipid metabolism_Homo sapiens_hsa005611.16141997
51Gastric acid secretion_Homo sapiens_hsa049711.15523286
52Influenza A_Homo sapiens_hsa051641.13472750
53Circadian rhythm_Homo sapiens_hsa047101.12921007
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12875294
55Phospholipase D signaling pathway_Homo sapiens_hsa040721.12799930
56Small cell lung cancer_Homo sapiens_hsa052221.11525195
57Ether lipid metabolism_Homo sapiens_hsa005651.10344947
58Platelet activation_Homo sapiens_hsa046111.10219323
59Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08221480
60ECM-receptor interaction_Homo sapiens_hsa045121.07982954
61Long-term depression_Homo sapiens_hsa047301.07035295
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06632297
63Dilated cardiomyopathy_Homo sapiens_hsa054141.06322162
64TNF signaling pathway_Homo sapiens_hsa046681.06260444
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06223071
66Focal adhesion_Homo sapiens_hsa045101.04278378
67Chemokine signaling pathway_Homo sapiens_hsa040621.03958818
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.99971932
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99386105
70MicroRNAs in cancer_Homo sapiens_hsa052060.99331717
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99198536
72Measles_Homo sapiens_hsa051620.98489569
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98085082
74Notch signaling pathway_Homo sapiens_hsa043300.96912757
75Dopaminergic synapse_Homo sapiens_hsa047280.96165031
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.95006850
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94942356
78Pancreatic cancer_Homo sapiens_hsa052120.94355015
79Amoebiasis_Homo sapiens_hsa051460.94225655
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94060265
81Phagosome_Homo sapiens_hsa041450.93134381
82ABC transporters_Homo sapiens_hsa020100.89407603
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88839394
84Insulin resistance_Homo sapiens_hsa049310.88779679
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.88525868
86Cocaine addiction_Homo sapiens_hsa050300.88501239
87Hedgehog signaling pathway_Homo sapiens_hsa043400.86824263
88mTOR signaling pathway_Homo sapiens_hsa041500.86627564
89Amphetamine addiction_Homo sapiens_hsa050310.86436215
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85872120
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.85444290
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.85041027
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84925219
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84448716
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83202787
96Histidine metabolism_Homo sapiens_hsa003400.83032683
97Apoptosis_Homo sapiens_hsa042100.82190971
98Glioma_Homo sapiens_hsa052140.82164386
99Choline metabolism in cancer_Homo sapiens_hsa052310.81907002
100T cell receptor signaling pathway_Homo sapiens_hsa046600.80763771
101Endocytosis_Homo sapiens_hsa041440.80183025
102Proteoglycans in cancer_Homo sapiens_hsa052050.79705611
103Rap1 signaling pathway_Homo sapiens_hsa040150.79614459
104Viral myocarditis_Homo sapiens_hsa054160.78355343
105Salmonella infection_Homo sapiens_hsa051320.77487317
106Rheumatoid arthritis_Homo sapiens_hsa053230.77315383
107Selenocompound metabolism_Homo sapiens_hsa004500.77110808
108Hepatitis C_Homo sapiens_hsa051600.75569154
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75013252
110Acute myeloid leukemia_Homo sapiens_hsa052210.74979429
111Basal cell carcinoma_Homo sapiens_hsa052170.74922113
112GnRH signaling pathway_Homo sapiens_hsa049120.74845992
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74836363
114Axon guidance_Homo sapiens_hsa043600.72801733
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.72650000
116Estrogen signaling pathway_Homo sapiens_hsa049150.72052224
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70935872
118African trypanosomiasis_Homo sapiens_hsa051430.70349999
119Hepatitis B_Homo sapiens_hsa051610.69453920
120Renin secretion_Homo sapiens_hsa049240.69385717
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66918105
122Hematopoietic cell lineage_Homo sapiens_hsa046400.66913201
123Collecting duct acid secretion_Homo sapiens_hsa049660.66671486
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.66300009
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65728126
126Prostate cancer_Homo sapiens_hsa052150.65548350
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65260337
128Renal cell carcinoma_Homo sapiens_hsa052110.64963033
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63792139
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62963243
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.62743214
132TGF-beta signaling pathway_Homo sapiens_hsa043500.62626010
133Shigellosis_Homo sapiens_hsa051310.62558758
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62228188
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.61186990
136cAMP signaling pathway_Homo sapiens_hsa040240.60752738
137Homologous recombination_Homo sapiens_hsa034400.60463483
138Long-term potentiation_Homo sapiens_hsa047200.60125764
139VEGF signaling pathway_Homo sapiens_hsa043700.59927138
140Adherens junction_Homo sapiens_hsa045200.59630547
141Pancreatic secretion_Homo sapiens_hsa049720.59536105
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59272548
143MAPK signaling pathway_Homo sapiens_hsa040100.59075779
144Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58924916
145Protein digestion and absorption_Homo sapiens_hsa049740.58547714
146Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56847902
147Calcium signaling pathway_Homo sapiens_hsa040200.56777250
148Insulin signaling pathway_Homo sapiens_hsa049100.56146575
149ErbB signaling pathway_Homo sapiens_hsa040120.56024148
150Ras signaling pathway_Homo sapiens_hsa040140.54858633
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.54760550
152FoxO signaling pathway_Homo sapiens_hsa040680.54669273
153Ovarian steroidogenesis_Homo sapiens_hsa049130.53333075
154Thyroid hormone synthesis_Homo sapiens_hsa049180.52934020
155Melanogenesis_Homo sapiens_hsa049160.52556105
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.51750837
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51495976
158Hippo signaling pathway_Homo sapiens_hsa043900.50519633
159Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48861854
160Bile secretion_Homo sapiens_hsa049760.48730175
161Regulation of autophagy_Homo sapiens_hsa041400.44675079
162Propanoate metabolism_Homo sapiens_hsa006400.44054754
163Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43276557
164Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42419624

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