STAT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.33337750
2negative T cell selection (GO:0043383)6.02095315
3negative thymic T cell selection (GO:0045060)5.99178900
4negative regulation of cell killing (GO:0031342)5.47410403
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.47410403
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.31454648
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.31454648
8regulation of gamma-delta T cell differentiation (GO:0045586)5.04764067
9antigen processing and presentation of endogenous antigen (GO:0019883)4.90228061
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.81243060
11interferon-gamma production (GO:0032609)4.77942659
12positive thymic T cell selection (GO:0045059)4.74789984
13regulation of isotype switching to IgG isotypes (GO:0048302)4.72190253
14response to interleukin-15 (GO:0070672)4.67252800
15cellular response to interleukin-15 (GO:0071350)4.65282941
16regulation of gamma-delta T cell activation (GO:0046643)4.57824954
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51589835
18thymic T cell selection (GO:0045061)4.50997862
19T cell migration (GO:0072678)4.44990162
20fusion of sperm to egg plasma membrane (GO:0007342)4.30398526
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.27069564
22T cell selection (GO:0045058)4.19540591
23NIK/NF-kappaB signaling (GO:0038061)4.17471081
24negative regulation of interleukin-12 production (GO:0032695)4.14888105
25positive regulation of tolerance induction (GO:0002645)4.11315088
26regulation of chronic inflammatory response (GO:0002676)4.08983007
27positive T cell selection (GO:0043368)4.03218634
28positive regulation of alpha-beta T cell proliferation (GO:0046641)4.01020925
29positive regulation of isotype switching (GO:0045830)3.96878156
30sperm motility (GO:0030317)3.93789063
31regulation of alpha-beta T cell proliferation (GO:0046640)3.93732207
32activated T cell proliferation (GO:0050798)3.92512043
33regulation of B cell receptor signaling pathway (GO:0050855)3.88990706
34antigen processing and presentation via MHC class Ib (GO:0002475)3.84310093
35regulation of T cell tolerance induction (GO:0002664)3.83312408
36regulation of interleukin-12 biosynthetic process (GO:0045075)3.75433422
37cell wall macromolecule catabolic process (GO:0016998)3.66610840
38cell wall macromolecule metabolic process (GO:0044036)3.66610840
39regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.65953251
40positive regulation of humoral immune response (GO:0002922)3.59791424
41leukocyte aggregation (GO:0070486)3.54682212
42regulation of natural killer cell mediated immunity (GO:0002715)3.53400935
43regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.53400935
44sequestering of actin monomers (GO:0042989)3.53345232
45sperm-egg recognition (GO:0035036)3.53016416
46regulation of T-helper 1 cell differentiation (GO:0045625)3.52761237
47positive regulation of defense response to virus by host (GO:0002230)3.52050936
48positive regulation of natural killer cell mediated immunity (GO:0002717)3.51281084
49positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.51281084
50ribosomal small subunit assembly (GO:0000028)3.51068098
51regulation of vitamin D biosynthetic process (GO:0060556)3.48748053
52regulation of regulatory T cell differentiation (GO:0045589)3.48687606
53cell-cell recognition (GO:0009988)3.45871417
54myeloid dendritic cell activation (GO:0001773)3.45382698
55regulation of B cell differentiation (GO:0045577)3.44953102
56multicellular organism reproduction (GO:0032504)3.44862277
57positive regulation of DNA recombination (GO:0045911)3.44724077
58interferon-gamma-mediated signaling pathway (GO:0060333)3.43591314
59T cell costimulation (GO:0031295)3.42403933
60lymphocyte costimulation (GO:0031294)3.41487397
61cytidine deamination (GO:0009972)3.38376055
62cytidine metabolic process (GO:0046087)3.38376055
63cytidine catabolic process (GO:0006216)3.38376055
64positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.38185607
65regulation of isotype switching (GO:0045191)3.37501411
66negative regulation of viral genome replication (GO:0045071)3.30263051
67positive regulation of interleukin-2 production (GO:0032743)3.29614647
68defense response to protozoan (GO:0042832)3.27411404
69regulation of tolerance induction (GO:0002643)3.25108195
70alpha-beta T cell differentiation involved in immune response (GO:0002293)3.24987030
71alpha-beta T cell activation involved in immune response (GO:0002287)3.24987030
72T cell differentiation involved in immune response (GO:0002292)3.24987030
73acrosome assembly (GO:0001675)3.20523246
74negative regulation of lymphocyte mediated immunity (GO:0002707)3.18785426
75regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18295047
76T cell receptor signaling pathway (GO:0050852)3.17901695
77plasma membrane fusion (GO:0045026)3.16389745
78binding of sperm to zona pellucida (GO:0007339)3.16140950
79positive regulation of lymphocyte mediated immunity (GO:0002708)3.15150782
80regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.15100942
81regulation of leukocyte mediated cytotoxicity (GO:0001910)3.13758582
82positive regulation of B cell differentiation (GO:0045579)3.13319704
83alpha-beta T cell differentiation (GO:0046632)3.13295234
84positive regulation of B cell mediated immunity (GO:0002714)3.13049231
85positive regulation of immunoglobulin mediated immune response (GO:0002891)3.13049231
86natural killer cell activation (GO:0030101)3.12444783
87pyrimidine ribonucleoside catabolic process (GO:0046133)3.11971921
88regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.11538942
89myeloid dendritic cell differentiation (GO:0043011)3.10887170
90positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.10433763
91regulation of interleukin-2 biosynthetic process (GO:0045076)3.10053082
92positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.09770810
93positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08698018
94DNA deamination (GO:0045006)3.08603219
95response to protozoan (GO:0001562)3.08581403
96B cell receptor signaling pathway (GO:0050853)3.07837817
97lymphocyte migration (GO:0072676)3.06056061
98positive regulation of granulocyte differentiation (GO:0030854)3.04805216
99Arp2/3 complex-mediated actin nucleation (GO:0034314)3.04461425
100antigen receptor-mediated signaling pathway (GO:0050851)3.03864230
101regulation of T cell receptor signaling pathway (GO:0050856)3.02566914
102reproduction (GO:0000003)3.02151982
103tolerance induction (GO:0002507)3.00376298
104type I interferon signaling pathway (GO:0060337)3.00296095
105cellular response to type I interferon (GO:0071357)3.00296095
106T-helper cell differentiation (GO:0042093)2.99760143
107CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.99760143
108response to type I interferon (GO:0034340)2.99736804
109regulation of T cell mediated cytotoxicity (GO:0001914)2.96014327
110alpha-beta T cell activation (GO:0046631)2.95646817
111regulation of alpha-beta T cell activation (GO:0046634)2.95489028
112regulation of interleukin-12 production (GO:0032655)2.94421785
113regulation of B cell mediated immunity (GO:0002712)2.94361479
114negative regulation of cytokine production involved in immune response (GO:0002719)2.93869326
115regulation of immunoglobulin mediated immune response (GO:0002889)2.91835836
116positive regulation of T cell mediated immunity (GO:0002711)2.90776866
117regulation of cell killing (GO:0031341)2.90703108
118regulation of necroptotic process (GO:0060544)2.90280767
119regulation of lymphocyte mediated immunity (GO:0002706)2.89668339
120T cell homeostasis (GO:0043029)2.89054379
121mature B cell differentiation (GO:0002335)2.88487058
122positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.88425119
123regulation of interferon-alpha production (GO:0032647)2.88406304
124mast cell activation (GO:0045576)2.88355119
125regulation of interleukin-2 production (GO:0032663)2.87928056
126acrosome reaction (GO:0007340)2.87865300
127regulation of immunoglobulin secretion (GO:0051023)2.87593422
128regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.86940853
129regulation of RIG-I signaling pathway (GO:0039535)2.86530384
130positive regulation of cell killing (GO:0031343)2.86486994
131regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.86482110
132positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86469662
133negative regulation of necroptotic process (GO:0060546)2.85623110
134positive regulation of natural killer cell differentiation (GO:0032825)2.84652212
135T cell proliferation (GO:0042098)2.82359261
136negative regulation of T cell mediated immunity (GO:0002710)2.78360447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.65259777
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.55523789
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.51930358
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.42114727
5E2F7_22180533_ChIP-Seq_HELA_Human3.92742223
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.69280899
7STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.39789204
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.28893075
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.24311771
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.18731401
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.05095512
12RUNX_20019798_ChIP-Seq_JUKART_Human3.00314146
13SCL_19346495_ChIP-Seq_HPC-7_Human2.99944551
14MYB_26560356_Chip-Seq_TH2_Human2.99122993
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.85938582
16* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.84512259
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70219993
18* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.62824199
19MYB_26560356_Chip-Seq_TH1_Human2.55103728
20MAF_26560356_Chip-Seq_TH1_Human2.44298320
21MYC_22102868_ChIP-Seq_BL_Human2.44235763
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.32208829
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.30587762
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28673571
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.23251767
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19373218
27NOTCH1_21737748_ChIP-Seq_TLL_Human2.18543031
28SPI1_23547873_ChIP-Seq_NB4_Human2.15253478
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.06050949
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.03450689
31UTX_26944678_Chip-Seq_JUKART_Human1.97792727
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96970344
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91560260
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.90211069
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86932771
36* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85310037
37* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84761521
38VDR_21846776_ChIP-Seq_THP-1_Human1.78666293
39GATA3_27048872_Chip-Seq_THYMUS_Human1.78189705
40* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73452634
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71822615
42TCF7_22412390_ChIP-Seq_EML_Mouse1.66466625
43* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65189747
44MAF_26560356_Chip-Seq_TH2_Human1.59660158
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54409061
46VDR_24763502_ChIP-Seq_THP-1_Human1.51551373
47E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51270586
48* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48621147
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45539351
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.45098290
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41235026
52VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.34132868
53* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.33787084
54* GATA3_26560356_Chip-Seq_TH2_Human1.31099959
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29117166
56* PU_27001747_Chip-Seq_BMDM_Mouse1.27021566
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26175454
58VDR_23849224_ChIP-Seq_CD4+_Human1.24034223
59* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23817077
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23349911
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21379561
62GATA1_22025678_ChIP-Seq_K562_Human1.20229965
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19781007
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.19201318
65SPI1_23127762_ChIP-Seq_K562_Human1.18380270
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17926183
67* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16637194
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12948623
69* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10238192
70GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09667906
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09390114
72FOXP3_21729870_ChIP-Seq_TREG_Human1.09039359
73* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09021709
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08304928
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07061062
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05093828
77* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02957543
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01475890
79* FLI1_27457419_Chip-Seq_LIVER_Mouse1.01475257
80EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99940828
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99637733
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98528215
83ETS1_22383799_ChIP-Seq_G1ME_Mouse0.98222252
84KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97747332
85* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96880050
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96801464
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95425917
88* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94421327
89* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93480473
90FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93358230
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.91231067
92SMRT_27268052_Chip-Seq_Bcells_Human0.87828991
93GATA1_19941827_ChIP-Seq_MEL_Mouse0.87177263
94* NFE2_27457419_Chip-Seq_LIVER_Mouse0.86974469
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86603265
96VDR_24787735_ChIP-Seq_THP-1_Human0.86399953
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86396428
98* GATA3_26560356_Chip-Seq_TH1_Human0.86358547
99CIITA_25753668_ChIP-Seq_RAJI_Human0.84690092
100* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84578138
101FOXM1_23109430_ChIP-Seq_U2OS_Human0.84022161
102ELK1_19687146_ChIP-ChIP_HELA_Human0.82605622
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82241653
104STAT6_21828071_ChIP-Seq_BEAS2B_Human0.81727426
105STAT1_20625510_ChIP-Seq_HELA_Human0.78694592
106TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78127979
107CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78103959
108* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77248741
109FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76706668
110KDM2B_26808549_Chip-Seq_DND41_Human0.76356999
111CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75987630
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75943597
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75515841
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75185869
115SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74979038
116RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.74404512
117FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73422161
118NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.71668921
119* EZH2_27294783_Chip-Seq_NPCs_Mouse0.71655581
120P300_27268052_Chip-Seq_Bcells_Human0.69674714
121* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66873915
122* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.66826171
123* CRX_20693478_ChIP-Seq_RETINA_Mouse0.66819527
124TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.66169163
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.64991914
126BCL6_27268052_Chip-Seq_Bcells_Human0.64002811
127EGR1_23403033_ChIP-Seq_LIVER_Mouse0.63925409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.29974565
2MP0001835_abnormal_antigen_presentation4.20675649
3MP0003763_abnormal_thymus_physiology3.96981681
4MP0000685_abnormal_immune_system3.91184325
5MP0005410_abnormal_fertilization3.40055343
6MP0001800_abnormal_humoral_immune3.15972242
7* MP0009785_altered_susceptibility_to2.96033497
8MP0001790_abnormal_immune_system2.95185313
9MP0005387_immune_system_phenotype2.95185313
10* MP0005000_abnormal_immune_tolerance2.74801130
11MP0002166_altered_tumor_susceptibility2.74800450
12* MP0002723_abnormal_immune_serum2.71845964
13* MP0002420_abnormal_adaptive_immunity2.66904257
14MP0002452_abnormal_antigen_presenting2.64738660
15* MP0001819_abnormal_immune_cell2.64644827
16* MP0002398_abnormal_bone_marrow2.59155251
17MP0002396_abnormal_hematopoietic_system2.52986345
18MP0001873_stomach_inflammation2.51793347
19* MP0005025_abnormal_response_to2.50175568
20MP0002148_abnormal_hypersensitivity_rea2.41804911
21MP0002405_respiratory_system_inflammati2.33274763
22MP0002006_tumorigenesis2.31222222
23* MP0000716_abnormal_immune_system2.28471482
24MP0006082_CNS_inflammation2.24456545
25MP0003436_decreased_susceptibility_to2.23509162
26MP0000689_abnormal_spleen_morphology2.06469440
27MP0002722_abnormal_immune_system2.06316348
28MP0001348_abnormal_lacrimal_gland2.06123683
29MP0000703_abnormal_thymus_morphology2.02340011
30MP0008057_abnormal_DNA_replication2.00614143
31MP0002419_abnormal_innate_immunity2.00465429
32MP0009333_abnormal_splenocyte_physiolog1.99771610
33MP0004808_abnormal_hematopoietic_stem1.90705040
34MP0005464_abnormal_platelet_physiology1.90528540
35* MP0002429_abnormal_blood_cell1.88593512
36MP0010155_abnormal_intestine_physiology1.87775553
37MP0003724_increased_susceptibility_to1.87485692
38MP0004947_skin_inflammation1.72145422
39MP0004510_myositis1.68455765
40MP0003866_abnormal_defecation1.66981950
41MP0001853_heart_inflammation1.64241080
42MP0005310_abnormal_salivary_gland1.63532125
43* MP0001845_abnormal_inflammatory_respons1.56661090
44MP0005397_hematopoietic_system_phenotyp1.56462716
45MP0001545_abnormal_hematopoietic_system1.56462716
46MP0003300_gastrointestinal_ulcer1.56225303
47MP0002009_preneoplasia1.50106690
48MP0003172_abnormal_lysosome_physiology1.40816570
49MP0005174_abnormal_tail_pigmentation1.37490159
50MP0000858_altered_metastatic_potential1.37318588
51MP0002138_abnormal_hepatobiliary_system1.35544402
52MP0002933_joint_inflammation1.32160234
53MP0000490_abnormal_crypts_of1.30139624
54MP0008877_abnormal_DNA_methylation1.28696246
55MP0005075_abnormal_melanosome_morpholog1.28623705
56MP0001929_abnormal_gametogenesis1.27861373
57MP0002163_abnormal_gland_morphology1.27786313
58MP0009840_abnormal_foam_cell1.27706400
59MP0005451_abnormal_body_composition1.23303116
60MP0003448_altered_tumor_morphology1.22993188
61MP0001501_abnormal_sleep_pattern1.19080818
62MP0003075_altered_response_to1.18779791
63MP0000465_gastrointestinal_hemorrhage1.17630663
64* MP0008469_abnormal_protein_level1.16031311
65MP0008007_abnormal_cellular_replicative1.15668693
66MP0002019_abnormal_tumor_incidence1.14829514
67MP0008058_abnormal_DNA_repair1.13726890
68MP0003698_abnormal_male_reproductive1.11058113
69MP0010094_abnormal_chromosome_stability1.09433584
70MP0003077_abnormal_cell_cycle1.06700867
71MP0010352_gastrointestinal_tract_polyps1.06505666
72MP0004381_abnormal_hair_follicle1.05761723
73MP0005167_abnormal_blood-brain_barrier1.05151489
74MP0000604_amyloidosis1.04053096
75MP0005166_decreased_susceptibility_to1.02066843
76MP0003303_peritoneal_inflammation0.99442098
77MP0005058_abnormal_lysosome_morphology0.99085851
78MP0002254_reproductive_system_inflammat0.95273401
79MP0002132_abnormal_respiratory_system0.94269146
80MP0003693_abnormal_embryo_hatching0.91826601
81MP0001533_abnormal_skeleton_physiology0.90958538
82* MP0002693_abnormal_pancreas_physiology0.88082098
83MP0006054_spinal_hemorrhage0.84791455
84MP0009278_abnormal_bone_marrow0.81308286
85MP0002332_abnormal_exercise_endurance0.77499621
86MP0010307_abnormal_tumor_latency0.76093950
87MP0003690_abnormal_glial_cell0.75851247
88MP0000343_altered_response_to0.75811759
89MP0002095_abnormal_skin_pigmentation0.74748017
90MP0003195_calcinosis0.72912739
91MP0008004_abnormal_stomach_pH0.72622670
92MP0003806_abnormal_nucleotide_metabolis0.72371244
93MP0003943_abnormal_hepatobiliary_system0.72312227
94MP0003045_fibrosis0.72001294
95MP0002210_abnormal_sex_determination0.71974675
96MP0002877_abnormal_melanocyte_morpholog0.68115052
97MP0005164_abnormal_response_to0.67977863
98MP0001851_eye_inflammation0.67465139
99MP0000313_abnormal_cell_death0.66736540
100MP0005390_skeleton_phenotype0.65277578
101MP0009763_increased_sensitivity_to0.65082903
102MP0004957_abnormal_blastocyst_morpholog0.63799730
103MP0008873_increased_physiological_sensi0.62351835
104MP0002998_abnormal_bone_remodeling0.62151632
105MP0009764_decreased_sensitivity_to0.61880927
106MP0003646_muscle_fatigue0.61742968
107MP0001145_abnormal_male_reproductive0.61573617
108MP0001919_abnormal_reproductive_system0.58258534
109MP0005535_abnormal_body_temperature0.58191465
110MP0003183_abnormal_peptide_metabolism0.57448356
111MP0002139_abnormal_hepatobiliary_system0.56689631
112MP0005379_endocrine/exocrine_gland_phen0.55754225
113MP0003656_abnormal_erythrocyte_physiolo0.55651339
114MP0002928_abnormal_bile_duct0.54801995
115MP0002277_abnormal_respiratory_mucosa0.53843068
116MP0000920_abnormal_myelination0.52882264
117MP0000015_abnormal_ear_pigmentation0.52009911
118MP0002161_abnormal_fertility/fecundity0.51690021
119MP0003111_abnormal_nucleus_morphology0.51539575
120MP0000569_abnormal_digit_pigmentation0.51055049
121MP0008874_decreased_physiological_sensi0.51040697
122MP0001765_abnormal_ion_homeostasis0.50216156
123MP0005023_abnormal_wound_healing0.50026809
124MP0000653_abnormal_sex_gland0.49801011
125MP0000249_abnormal_blood_vessel0.48891281
126MP0009765_abnormal_xenobiotic_induced0.48617792
127MP0004883_abnormal_blood_vessel0.48499609
128MP0004130_abnormal_muscle_cell0.47302600
129MP0001191_abnormal_skin_condition0.47040605
130MP0003795_abnormal_bone_structure0.46948619
131MP0002136_abnormal_kidney_physiology0.46878120
132MP0005381_digestive/alimentary_phenotyp0.45609795
133MP0001663_abnormal_digestive_system0.45607185
134MP0000477_abnormal_intestine_morphology0.41256525

Predicted human phenotypes

RankGene SetZ-score
1Nasal polyposis (HP:0100582)6.15774959
2Abnormality of the nasal mucosa (HP:0000433)5.30596394
3Recurrent bronchitis (HP:0002837)5.12945362
4Abnormality of T cell number (HP:0011839)5.05033526
5T lymphocytopenia (HP:0005403)4.88063683
6* Myositis (HP:0100614)4.71869900
7Elevated erythrocyte sedimentation rate (HP:0003565)4.61034210
8Chronic otitis media (HP:0000389)4.34301429
9Thrombocytosis (HP:0001894)4.31023159
10Dynein arm defect of respiratory motile cilia (HP:0012255)4.30757849
11Absent/shortened dynein arms (HP:0200106)4.30757849
12Abnormality of T cells (HP:0002843)4.04167295
13Bronchitis (HP:0012387)3.94685198
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.93291928
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.76402080
16Recurrent fungal infections (HP:0002841)3.73750396
17Abnormality of macrophages (HP:0004311)3.70580687
18Recurrent sinusitis (HP:0011108)3.69923031
19Panhypogammaglobulinemia (HP:0003139)3.69826268
20Recurrent viral infections (HP:0004429)3.67860907
21Recurrent abscess formation (HP:0002722)3.66494071
22IgM deficiency (HP:0002850)3.62178820
23Increased IgM level (HP:0003496)3.58909104
24Eczematoid dermatitis (HP:0000976)3.56507900
25Severe combined immunodeficiency (HP:0004430)3.55283811
26IgG deficiency (HP:0004315)3.50880583
27* Optic neuritis (HP:0100653)3.49851061
28* Retrobulbar optic neuritis (HP:0100654)3.49851061
29Recurrent bacterial skin infections (HP:0005406)3.31161786
30* Orchitis (HP:0100796)3.23940734
31Bronchiectasis (HP:0002110)3.20646284
32Combined immunodeficiency (HP:0005387)3.18782302
33Abnormality of T cell physiology (HP:0011840)3.17468033
34* Meningitis (HP:0001287)3.13802767
35Abnormality of the fingertips (HP:0001211)3.10478528
36* Vasculitis (HP:0002633)3.09927749
37Thyroiditis (HP:0100646)3.09246609
38Abnormality of B cell number (HP:0010975)3.05696550
39B lymphocytopenia (HP:0010976)3.05696550
40Abnormality of eosinophils (HP:0001879)3.03218606
41Autoimmune hemolytic anemia (HP:0001890)2.99637133
42Abnormal respiratory motile cilium morphology (HP:0005938)2.90323126
43Abnormal respiratory epithelium morphology (HP:0012253)2.90323126
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.87745356
45Abnormality of liposaccharide metabolism (HP:0010968)2.86414164
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.86414164
47Abnormality of glycolipid metabolism (HP:0010969)2.86414164
48* Encephalitis (HP:0002383)2.85175962
49Leukocytosis (HP:0001974)2.84364220
50Agammaglobulinemia (HP:0004432)2.83008273
51Autoimmune thrombocytopenia (HP:0001973)2.82328606
52Stomatitis (HP:0010280)2.80768255
53Lymphopenia (HP:0001888)2.79180289
54Eosinophilia (HP:0001880)2.79039185
55Chronic sinusitis (HP:0011109)2.75373116
56Mediastinal lymphadenopathy (HP:0100721)2.73195286
57Abnormality of the prostate (HP:0008775)2.71718593
58Rhinitis (HP:0012384)2.71169361
59* Arterial thrombosis (HP:0004420)2.70592204
60* Gangrene (HP:0100758)2.69439591
61Hematochezia (HP:0002573)2.69122793
62* Pulmonary infiltrates (HP:0002113)2.68619735
63Hypergammaglobulinemia (HP:0010702)2.68164740
64Chronic mucocutaneous candidiasis (HP:0002728)2.67413468
65Recurrent cutaneous fungal infections (HP:0011370)2.67413468
66Inflammation of the large intestine (HP:0002037)2.64742965
67Abnormal respiratory motile cilium physiology (HP:0012261)2.63053306
68Amaurosis fugax (HP:0100576)2.61568989
69Granulocytopenia (HP:0001913)2.61503847
70Chronic diarrhea (HP:0002028)2.60589730
71Recurrent otitis media (HP:0000403)2.59983393
72Obstructive lung disease (HP:0006536)2.59798387
73Chronic obstructive pulmonary disease (HP:0006510)2.59798387
74Gastrointestinal inflammation (HP:0004386)2.57513779
75Gastrointestinal infarctions (HP:0005244)2.56946430
76* Hemoptysis (HP:0002105)2.54667972
77Recurrent skin infections (HP:0001581)2.52100313
78Acute myeloid leukemia (HP:0004808)2.51959733
79Chest pain (HP:0100749)2.46344865
80Prolonged bleeding time (HP:0003010)2.45387979
81Loss of speech (HP:0002371)2.44466227
82Spontaneous hematomas (HP:0007420)2.42244341
83* Keratoconjunctivitis sicca (HP:0001097)2.41961738
84* Polyneuropathy (HP:0001271)2.40681422
85Epistaxis (HP:0000421)2.40430791
86Lymphoma (HP:0002665)2.39910067
87IgA deficiency (HP:0002720)2.36800700
88Petechiae (HP:0000967)2.30751389
89Hypoproteinemia (HP:0003075)2.30587002
90Pustule (HP:0200039)2.27366065
91Increased IgE level (HP:0003212)2.24287481
92Cellulitis (HP:0100658)2.22197647
93Colitis (HP:0002583)2.22158097
94Hypochromic anemia (HP:0001931)2.21385792
95Disinhibition (HP:0000734)2.20689286
96Recurrent gram-negative bacterial infections (HP:0005420)2.20630021
97Vacuolated lymphocytes (HP:0001922)2.19175028
98* Keratoconjunctivitis (HP:0001096)2.17342289
99Chronic bronchitis (HP:0004469)2.17294952
100Fatigue (HP:0012378)2.14665947
101Infertility (HP:0000789)2.13292431
102Reticulocytopenia (HP:0001896)2.09001537
103* Abnormality of the pleura (HP:0002103)2.08849325
104Increased cerebral lipofuscin (HP:0011813)2.07266040
105Parakeratosis (HP:0001036)2.06671112
106* Anorexia (HP:0002039)2.06287848
107Abnormal ciliary motility (HP:0012262)2.05860877
108Urticaria (HP:0001025)2.05731853
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02840699
110Gingival bleeding (HP:0000225)2.02380643
111Myelodysplasia (HP:0002863)2.00731435
112Alveolar cell carcinoma (HP:0006519)2.00564472
113Hepatosplenomegaly (HP:0001433)1.98689683
114Dysostosis multiplex (HP:0000943)1.97598177
115Episodic fever (HP:0001954)1.97394383
116Increased serum ferritin (HP:0003281)1.97325648
117Gastrointestinal stroma tumor (HP:0100723)1.95734193
118Gingivitis (HP:0000230)1.95472145
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94685577
120Abnormal platelet function (HP:0011869)1.94393007
121Impaired platelet aggregation (HP:0003540)1.94393007
122Aplastic anemia (HP:0001915)1.93814494
123* Joint swelling (HP:0001386)1.93348094
124* Arthralgia (HP:0002829)1.93201843
125Hypoplasia of the thymus (HP:0000778)1.92906425
126Abnormal spermatogenesis (HP:0008669)1.91494321
127* Pulmonary embolism (HP:0002204)1.90775727
128Mutism (HP:0002300)1.87781148
129Increased neuronal autofluorescent lipopigment (HP:0002074)1.86482575
130* Glomerulopathy (HP:0100820)1.86361517
131Basal ganglia calcification (HP:0002135)1.84854096
132* Keratitis (HP:0000491)1.84184660
133Upper motor neuron abnormality (HP:0002127)1.83570951
134Neoplasm of the tracheobronchial system (HP:0100552)1.82180647
135Stomach cancer (HP:0012126)1.82102202
136* Abnormality of the endocardium (HP:0004306)1.80937799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.73241098
2MAP4K14.70824783
3JAK33.18903146
4MAP3K143.18327532
5TYK22.86081109
6IKBKE2.58006419
7ZAP702.54073218
8ITK2.51276367
9GRK72.39026320
10KIT2.21410923
11TBK12.18016946
12JAK12.12835454
13TEC2.09803951
14BTK2.05706135
15IKBKB2.05038733
16STK101.85964085
17FGFR41.82739269
18SYK1.73500634
19TESK11.70927422
20NLK1.69868825
21PDK41.68397422
22PDK31.68397422
23LCK1.64554022
24IRAK41.53630889
25EEF2K1.50386054
26MAP3K131.46846288
27FLT31.42448259
28FGFR31.41656664
29CAMKK21.40103805
30PRPF4B1.39717389
31GRK61.39137865
32TGFBR11.38447446
33BLK1.35631970
34PIM11.34567222
35CHUK1.30749589
36CSF1R1.30621898
37CSK1.27868160
38ACVR1B1.27431224
39HCK1.27229613
40MAP3K111.22459650
41TYRO31.09932206
42RIPK11.05185431
43EPHA31.04475288
44SRPK11.04400223
45NME21.01016947
46TAOK31.00713451
47MAP2K30.98803343
48LRRK20.96404419
49MST40.96385092
50TAOK20.93026260
51NEK20.92407949
52EPHB10.90661050
53LYN0.90057513
54TLK10.89836454
55PASK0.87442216
56IRAK30.83657105
57FGR0.83596740
58MAP3K30.81947462
59PRKCQ0.80780306
60IRAK10.79681773
61FES0.77584997
62BMPR20.77328714
63MAP3K10.76417157
64TAOK10.75543892
65TGFBR20.74067230
66MAP3K120.72915612
67CDK40.72294541
68JAK20.70869887
69CLK10.70664147
70MARK30.70520432
71RPS6KA40.69965092
72MOS0.68479303
73HIPK20.68267580
74CAMKK10.66848009
75PDK20.66576286
76* MAP2K60.66289040
77PIK3CG0.63271844
78ATR0.62625181
79MAP3K100.62603476
80STK240.62120508
81WEE10.58669729
82SIK30.57825284
83MELK0.57103694
84PDK10.56604342
85CDK90.56281343
86PIK3CA0.54554899
87TNK20.52792723
88CDC70.50767558
89PIM20.50299176
90SIK20.50049810
91RPS6KB20.50032946
92TSSK60.48563705
93CDK120.47561586
94MAP3K70.47523274
95CDK80.46910486
96RIPK40.46798022
97FYN0.44811755
98TESK20.44683708
99FRK0.41619033
100KDR0.40074873
101CDC42BPA0.39443414
102TRPM70.38551933
103MAP3K50.36429351
104NEK90.35412214
105GRK50.34686892
106ADRBK20.34383692
107MATK0.34084027
108STK40.33765982
109DYRK1B0.33211531
110CDK60.32977615
111MAPK70.32487878
112BRSK20.32383683
113MUSK0.31996435
114IGF1R0.30637508
115EGFR0.30374382
116MAPKAPK20.30112439
117INSR0.29344246
118PKN20.28865003
119DAPK20.28802986
120PRKG20.27980471
121PDGFRB0.26456946
122PRKCD0.26368195
123ERN10.26289901
124RPS6KA50.26095340
125BMPR1B0.24869097
126CCNB10.24564661
127PDPK10.24350609
128PTK2B0.23212928
129RPS6KA60.22803137
130MAPK110.22587307
131PRKD30.22055339
132PRKCH0.22045963
133PINK10.20353067
134ABL10.19890629
135IRAK20.17588335
136MAPK30.17474473
137MAPK120.15471107
138EIF2AK20.15334828

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.32194644
2Allograft rejection_Homo sapiens_hsa053303.75948700
3Graft-versus-host disease_Homo sapiens_hsa053323.61987377
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.15972410
5Antigen processing and presentation_Homo sapiens_hsa046122.90900182
6Autoimmune thyroid disease_Homo sapiens_hsa053202.76830606
7Measles_Homo sapiens_hsa051622.73365049
8* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.67629498
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.67616673
10T cell receptor signaling pathway_Homo sapiens_hsa046602.58528020
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.51393116
12Leishmaniasis_Homo sapiens_hsa051402.03735985
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98021198
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92821439
15B cell receptor signaling pathway_Homo sapiens_hsa046621.92487212
16Herpes simplex infection_Homo sapiens_hsa051681.83773512
17Osteoclast differentiation_Homo sapiens_hsa043801.75973055
18Hematopoietic cell lineage_Homo sapiens_hsa046401.75387561
19* Jak-STAT signaling pathway_Homo sapiens_hsa046301.72890279
20DNA replication_Homo sapiens_hsa030301.65649954
21Viral myocarditis_Homo sapiens_hsa054161.62449634
22Ribosome_Homo sapiens_hsa030101.61170518
23Type I diabetes mellitus_Homo sapiens_hsa049401.59464019
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46369678
25Toxoplasmosis_Homo sapiens_hsa051451.41844752
26Influenza A_Homo sapiens_hsa051641.40436439
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36570259
28TNF signaling pathway_Homo sapiens_hsa046681.29370162
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26984134
30Mismatch repair_Homo sapiens_hsa034301.26390907
31Asthma_Homo sapiens_hsa053101.22764416
32Chemokine signaling pathway_Homo sapiens_hsa040621.16991243
33Legionellosis_Homo sapiens_hsa051341.16263908
34Acute myeloid leukemia_Homo sapiens_hsa052211.14022177
35Base excision repair_Homo sapiens_hsa034101.12344269
36Epstein-Barr virus infection_Homo sapiens_hsa051691.11060502
37Apoptosis_Homo sapiens_hsa042101.10244860
38Shigellosis_Homo sapiens_hsa051311.09864421
39* Hepatitis B_Homo sapiens_hsa051611.08190029
40Non-homologous end-joining_Homo sapiens_hsa034501.06294191
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05178605
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02524102
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98529546
44Homologous recombination_Homo sapiens_hsa034400.97562277
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94711495
46p53 signaling pathway_Homo sapiens_hsa041150.94371850
47Fanconi anemia pathway_Homo sapiens_hsa034600.94111942
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.91054203
49Spliceosome_Homo sapiens_hsa030400.90754775
50Malaria_Homo sapiens_hsa051440.90514637
51Basal transcription factors_Homo sapiens_hsa030220.87807042
52Lysosome_Homo sapiens_hsa041420.87771259
53HTLV-I infection_Homo sapiens_hsa051660.86549267
54RNA degradation_Homo sapiens_hsa030180.83866443
55Viral carcinogenesis_Homo sapiens_hsa052030.80912239
56Platelet activation_Homo sapiens_hsa046110.78727833
57Nucleotide excision repair_Homo sapiens_hsa034200.72669232
58Tuberculosis_Homo sapiens_hsa051520.69938645
59Rheumatoid arthritis_Homo sapiens_hsa053230.67178305
60Pertussis_Homo sapiens_hsa051330.65030289
61Pancreatic cancer_Homo sapiens_hsa052120.64639022
62Prolactin signaling pathway_Homo sapiens_hsa049170.61486935
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61038325
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60911206
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60872275
66Hepatitis C_Homo sapiens_hsa051600.60849529
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59899457
68Pyrimidine metabolism_Homo sapiens_hsa002400.59767652
69Proteasome_Homo sapiens_hsa030500.58992738
70Chronic myeloid leukemia_Homo sapiens_hsa052200.58613208
71Cell cycle_Homo sapiens_hsa041100.58523310
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57542899
73Dorso-ventral axis formation_Homo sapiens_hsa043200.57389053
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55649741
75Fatty acid biosynthesis_Homo sapiens_hsa000610.54140819
76RNA transport_Homo sapiens_hsa030130.53086839
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52604498
78Salmonella infection_Homo sapiens_hsa051320.52283516
79Small cell lung cancer_Homo sapiens_hsa052220.51635188
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51125806
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50223048
82Staphylococcus aureus infection_Homo sapiens_hsa051500.48447502
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47307679
84African trypanosomiasis_Homo sapiens_hsa051430.46609027
85Phagosome_Homo sapiens_hsa041450.46448121
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46244944
87VEGF signaling pathway_Homo sapiens_hsa043700.44272355
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.41319633
89Pentose phosphate pathway_Homo sapiens_hsa000300.41180608
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.40868012
91Colorectal cancer_Homo sapiens_hsa052100.39370256
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.38248506
93MAPK signaling pathway_Homo sapiens_hsa040100.36900405
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35860810
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35202662
96Linoleic acid metabolism_Homo sapiens_hsa005910.34773974
97mRNA surveillance pathway_Homo sapiens_hsa030150.34531788
98Purine metabolism_Homo sapiens_hsa002300.32205090
99Prion diseases_Homo sapiens_hsa050200.30902934
100Inositol phosphate metabolism_Homo sapiens_hsa005620.28482484
101Systemic lupus erythematosus_Homo sapiens_hsa053220.27445778
102Endocytosis_Homo sapiens_hsa041440.26749831
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.25787394
104Other glycan degradation_Homo sapiens_hsa005110.25036022
105Ether lipid metabolism_Homo sapiens_hsa005650.24572080
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24410475
107HIF-1 signaling pathway_Homo sapiens_hsa040660.24154865
108RNA polymerase_Homo sapiens_hsa030200.23685223
109Collecting duct acid secretion_Homo sapiens_hsa049660.23245416
110Type II diabetes mellitus_Homo sapiens_hsa049300.22927205
111Non-small cell lung cancer_Homo sapiens_hsa052230.22824353
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22651244
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22109035
114FoxO signaling pathway_Homo sapiens_hsa040680.21941045
115Insulin resistance_Homo sapiens_hsa049310.21421870
116One carbon pool by folate_Homo sapiens_hsa006700.20270763
117Notch signaling pathway_Homo sapiens_hsa043300.20112983
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.18394649
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17835795
120Regulation of autophagy_Homo sapiens_hsa041400.15284005
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14078575
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13153051
123Amoebiasis_Homo sapiens_hsa051460.12392797
124Ras signaling pathway_Homo sapiens_hsa040140.06229131
125Arachidonic acid metabolism_Homo sapiens_hsa005900.05230511
126Mineral absorption_Homo sapiens_hsa049780.04045180
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.02591481
128Caffeine metabolism_Homo sapiens_hsa002320.00737864
129Tryptophan metabolism_Homo sapiens_hsa00380-0.0110899
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0039459

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