STAT5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.04177026
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.04177026
3antigen processing and presentation of endogenous antigen (GO:0019883)5.34162922
4positive regulation by symbiont of host defense response (GO:0052509)5.11373400
5modulation by symbiont of host defense response (GO:0052031)5.11373400
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.11373400
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.11373400
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.11373400
9modulation by symbiont of host immune response (GO:0052553)5.11373400
10* regulation of gamma-delta T cell differentiation (GO:0045586)4.98466903
11* positive regulation of gamma-delta T cell activation (GO:0046645)4.94072141
12detection of other organism (GO:0098543)4.55356622
13positive thymic T cell selection (GO:0045059)4.52842998
14* regulation of gamma-delta T cell activation (GO:0046643)4.37538333
15detection of bacterium (GO:0016045)4.35641717
16negative regulation of lymphocyte mediated immunity (GO:0002707)4.23799034
17negative T cell selection (GO:0043383)4.19527012
18neutrophil activation involved in immune response (GO:0002283)4.16750228
19cellular extravasation (GO:0045123)4.15567949
20* negative regulation of erythrocyte differentiation (GO:0045647)4.11345598
21B cell receptor signaling pathway (GO:0050853)4.02038244
22macrophage activation involved in immune response (GO:0002281)4.02023453
23negative thymic T cell selection (GO:0045060)3.99444769
24response to peptidoglycan (GO:0032494)3.93638079
25negative regulation of T cell mediated immunity (GO:0002710)3.91396404
26detection of external biotic stimulus (GO:0098581)3.90998288
27positive T cell selection (GO:0043368)3.89628935
28negative regulation of cell killing (GO:0031342)3.87734174
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87734174
30thymic T cell selection (GO:0045061)3.80082910
31detection of molecule of bacterial origin (GO:0032490)3.77200546
32negative regulation of leukocyte mediated immunity (GO:0002704)3.75420504
33germinal center formation (GO:0002467)3.66049631
34negative regulation of interleukin-12 production (GO:0032695)3.63309724
35T cell selection (GO:0045058)3.59838152
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.58753219
37negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.58168790
38regulation of interferon-beta biosynthetic process (GO:0045357)3.57888100
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55849582
40positive regulation of histone deacetylation (GO:0031065)3.55554716
41response to muramyl dipeptide (GO:0032495)3.50879151
42positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.48319892
43response to host immune response (GO:0052572)3.44521927
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.44521927
45regulation of interleukin-12 biosynthetic process (GO:0045075)3.44325792
46detection of biotic stimulus (GO:0009595)3.42288900
47* valine metabolic process (GO:0006573)3.41614835
48positive regulation of granulocyte differentiation (GO:0030854)3.40747690
49* response to interleukin-15 (GO:0070672)3.38498722
50alpha-linolenic acid metabolic process (GO:0036109)3.37631003
51tolerance induction (GO:0002507)3.37595073
52respiratory burst (GO:0045730)3.32254795
53neutrophil activation (GO:0042119)3.32073610
54fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.28157593
55immunoglobulin mediated immune response (GO:0016064)3.27197740
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26891640
57response to host (GO:0075136)3.26891640
58response to host defenses (GO:0052200)3.26891640
59activated T cell proliferation (GO:0050798)3.26284946
60* JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.25292532
61regulation of alpha-beta T cell proliferation (GO:0046640)3.23303561
62leukocyte migration involved in inflammatory response (GO:0002523)3.21765148
63regulation of mast cell degranulation (GO:0043304)3.20520751
64myeloid cell activation involved in immune response (GO:0002275)3.19232369
65erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.16617890
66L-phenylalanine catabolic process (GO:0006559)3.16617890
67regulation of cholesterol homeostasis (GO:2000188)3.15179388
68negative regulation of T-helper cell differentiation (GO:0045623)3.15166240
69negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.15166240
70regulation of tolerance induction (GO:0002643)3.14015778
71lysine catabolic process (GO:0006554)3.12976515
72lysine metabolic process (GO:0006553)3.12976515
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.11743487
74negative regulation of phagocytosis (GO:0050765)3.11566869
75* 2-oxoglutarate metabolic process (GO:0006103)3.11305510
76microglial cell activation (GO:0001774)3.11121079
77L-phenylalanine metabolic process (GO:0006558)3.09487954
78erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.09487954
79type I interferon signaling pathway (GO:0060337)3.05842212
80cellular response to type I interferon (GO:0071357)3.05842212
81kynurenine metabolic process (GO:0070189)3.05782617
82response to type I interferon (GO:0034340)3.05268666
83leukocyte degranulation (GO:0043299)3.04536174
84production of molecular mediator involved in inflammatory response (GO:0002532)3.03565300
85growth hormone receptor signaling pathway (GO:0060396)3.01999986
86cellular response to interleukin-15 (GO:0071350)3.01346312
87antigen processing and presentation via MHC class Ib (GO:0002475)3.00806861
88peptidyl-glutamic acid carboxylation (GO:0017187)3.00333527
89protein carboxylation (GO:0018214)3.00333527
90regulation of myeloid leukocyte mediated immunity (GO:0002886)3.00057811
91macrophage activation (GO:0042116)2.98457939
92defense response to protozoan (GO:0042832)2.97882216
93triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.97735370
94granulocyte activation (GO:0036230)2.97453395
95complement activation, alternative pathway (GO:0006957)2.95596724
96negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.95582910
97* positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.93481912
98regulation of leukocyte degranulation (GO:0043300)2.92523899
99regulation of granulocyte differentiation (GO:0030852)2.91716383
100regulation of fatty acid beta-oxidation (GO:0031998)2.91593461
101negative regulation of innate immune response (GO:0045824)2.90505897
102regulation of mast cell activation involved in immune response (GO:0033006)2.88426089
103urea metabolic process (GO:0019627)2.86956419
104urea cycle (GO:0000050)2.86956419
105antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.85732440
106cysteine metabolic process (GO:0006534)2.82982301
107aromatic amino acid family catabolic process (GO:0009074)2.82297441
108neutrophil mediated immunity (GO:0002446)2.82052307
109positive regulation of tolerance induction (GO:0002645)2.80619579
110positive regulation of fatty acid beta-oxidation (GO:0032000)2.80299595
111negative regulation of adaptive immune response (GO:0002820)2.80023608
112regulation of T-helper 2 cell differentiation (GO:0045628)2.78888515
113* regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78883547
114* regulation of natural killer cell mediated immunity (GO:0002715)2.78883547
115interferon-gamma production (GO:0032609)2.78410471
116positive regulation of humoral immune response (GO:0002922)2.78116615
117negative regulation of type 2 immune response (GO:0002829)2.77911652
118regulation of regulatory T cell differentiation (GO:0045589)2.77671895
119dicarboxylic acid biosynthetic process (GO:0043650)2.77339605
120T cell costimulation (GO:0031295)2.76413474
121regulation of B cell receptor signaling pathway (GO:0050855)2.74028514
122negative regulation of fibrinolysis (GO:0051918)2.72710064
123regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.72280954
124T cell migration (GO:0072678)2.71802196
125regulation of T cell tolerance induction (GO:0002664)2.71530045
126regulation of response to interferon-gamma (GO:0060330)2.70300695
127lymphocyte costimulation (GO:0031294)2.69954091
128regulation of triglyceride catabolic process (GO:0010896)2.69553707
129regulation of isotype switching to IgG isotypes (GO:0048302)2.69330277
130negative regulation of cholesterol transport (GO:0032375)2.69317556
131negative regulation of sterol transport (GO:0032372)2.69317556
132NIK/NF-kappaB signaling (GO:0038061)2.68946925
133T cell receptor signaling pathway (GO:0050852)2.67234446
134fatty acid transmembrane transport (GO:1902001)2.64044523
135regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.62186601
136regulation of protein activation cascade (GO:2000257)2.61510152
137plasma lipoprotein particle assembly (GO:0034377)2.59679269
138* positive regulation of B cell differentiation (GO:0045579)2.59449929
139cellular response to growth hormone stimulus (GO:0071378)2.58965170
140sulfur amino acid catabolic process (GO:0000098)2.56261417
141protein-lipid complex assembly (GO:0065005)2.56001923
142nitrogen cycle metabolic process (GO:0071941)2.55582523
143* oxaloacetate metabolic process (GO:0006107)2.55545988
144regulation of type I interferon-mediated signaling pathway (GO:0060338)2.55172524
145phospholipid efflux (GO:0033700)2.54696145
146leukocyte aggregation (GO:0070486)2.53751036
147indole-containing compound catabolic process (GO:0042436)2.53566759
148indolalkylamine catabolic process (GO:0046218)2.53566759
149tryptophan catabolic process (GO:0006569)2.53566759
150positive regulation of protein deacetylation (GO:0090312)2.52063104
151carnitine shuttle (GO:0006853)2.51008663
152phospholipid homeostasis (GO:0055091)2.49864219
153bile acid biosynthetic process (GO:0006699)2.49445070
154* regulation of B cell differentiation (GO:0045577)2.48658108
155glyoxylate metabolic process (GO:0046487)2.48517571
156high-density lipoprotein particle remodeling (GO:0034375)2.47787252
157positive regulation of triglyceride biosynthetic process (GO:0010867)2.46804265
158positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.46788711
159regulation of complement activation (GO:0030449)2.46100334
160ethanol oxidation (GO:0006069)2.45715430
161* tricarboxylic acid metabolic process (GO:0072350)2.45418611
162regulation of fibrinolysis (GO:0051917)2.40819269
163regulation of cholesterol storage (GO:0010885)2.40511812
164plasma lipoprotein particle clearance (GO:0034381)2.40179803
165regulation of fatty acid oxidation (GO:0046320)2.39238559
166antigen receptor-mediated signaling pathway (GO:0050851)2.38606732
167tryptophan metabolic process (GO:0006568)2.37957830
168positive regulation of triglyceride metabolic process (GO:0090208)2.35568020
169positive regulation of lipid catabolic process (GO:0050996)2.34988042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.78197461
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.04769291
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74733359
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.40378115
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.35317417
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.29490921
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.29466995
8MYC_22102868_ChIP-Seq_BL_Human3.13835421
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98639060
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.74053618
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.51294719
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.48492276
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.48029842
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.42624910
15MAF_26560356_Chip-Seq_TH1_Human2.40284050
16RUNX_20019798_ChIP-Seq_JUKART_Human2.39786827
17VDR_21846776_ChIP-Seq_THP-1_Human2.37163038
18GATA1_22025678_ChIP-Seq_K562_Human2.35599068
19* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25598960
20TCF7_22412390_ChIP-Seq_EML_Mouse2.24368927
21SCL_19346495_ChIP-Seq_HPC-7_Human2.16265036
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16106204
23UTX_26944678_Chip-Seq_JUKART_Human2.14203514
24MYB_26560356_Chip-Seq_TH2_Human2.07551368
25* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.07483002
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.05118574
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.02929386
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.02474802
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00103116
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97098649
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.95241469
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93795878
33KDM2B_26808549_Chip-Seq_DND41_Human1.88678344
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88346152
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.87288060
36* MYB_26560356_Chip-Seq_TH1_Human1.87259603
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85938686
38* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85445895
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85129338
40CLOCK_20551151_ChIP-Seq_293T_Human1.81282799
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80363782
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76633011
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76377990
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.75837627
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.74262388
46VDR_24763502_ChIP-Seq_THP-1_Human1.71397813
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70655057
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.62576987
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.59472440
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.58470869
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55565333
52* RUNX1_22412390_ChIP-Seq_EML_Mouse1.54852396
53MAF_26560356_Chip-Seq_TH2_Human1.54538437
54* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51645242
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50596840
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.49060675
57GATA3_27048872_Chip-Seq_THYMUS_Human1.48764601
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.42786743
59LXR_22292898_ChIP-Seq_THP-1_Human1.37777927
60SPI1_23127762_ChIP-Seq_K562_Human1.36982221
61GATA1_19941826_ChIP-Seq_K562_Human1.35518267
62VDR_24787735_ChIP-Seq_THP-1_Human1.34964731
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30971918
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30050654
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29454114
66ZNF263_19887448_ChIP-Seq_K562_Human1.27706877
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26420285
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25125781
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22558801
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.19011871
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18235409
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15025567
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14715644
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14170089
75SPI1_23547873_ChIP-Seq_NB4_Human1.13825391
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.12479148
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11786015
78GATA2_19941826_ChIP-Seq_K562_Human1.11264711
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11106666
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11009032
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09998351
82KDM2B_26808549_Chip-Seq_K562_Human1.07975274
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07965018
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07820188
85NCOR1_26117541_ChIP-Seq_K562_Human1.07766458
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07068936
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06218255
88TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04797954
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03646162
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03194986
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03102536
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02158591
93PU_27001747_Chip-Seq_BMDM_Mouse1.01213880
94CIITA_25753668_ChIP-Seq_RAJI_Human1.01047787
95RACK7_27058665_Chip-Seq_MCF-7_Human1.00537491
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00525461
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99443571
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.98533577
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98007315
100* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97756656
101* TBX20_22080862_ChIP-Seq_HEART_Mouse0.97750621
102* TBX20_22328084_ChIP-Seq_HEART_Mouse0.97750621
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.96211520
104* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94298450
105CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93651813
106CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92911345
107SA1_27219007_Chip-Seq_ERYTHROID_Human0.90681593
108NOTCH1_21737748_ChIP-Seq_TLL_Human0.90380172
109* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90208421
110RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89291046
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89093638
112IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88765590
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87993570
114BCOR_27268052_Chip-Seq_Bcells_Human0.87611746
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86713083
116EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86522882
117GATA3_26560356_Chip-Seq_TH2_Human0.86355608
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85928382
119FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85417199
120* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85409438
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84886510
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84714394
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84634447
124ELF1_17652178_ChIP-ChIP_JURKAT_Human0.83985340
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83937283
126* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.83810091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.21558063
2MP0005360_urolithiasis3.09054599
3MP0000685_abnormal_immune_system2.77646346
4MP0003300_gastrointestinal_ulcer2.74344234
5MP0005365_abnormal_bile_salt2.74271879
6MP0003763_abnormal_thymus_physiology2.65936684
7MP0001835_abnormal_antigen_presentation2.31311497
8MP0005085_abnormal_gallbladder_physiolo2.25691278
9MP0003436_decreased_susceptibility_to2.22091613
10MP0002166_altered_tumor_susceptibility2.20260861
11MP0005451_abnormal_body_composition2.18498348
12MP0005387_immune_system_phenotype2.13726317
13MP0001790_abnormal_immune_system2.13726317
14MP0001800_abnormal_humoral_immune2.09199010
15MP0005671_abnormal_response_to2.08837530
16MP0009840_abnormal_foam_cell2.06949742
17MP0003303_peritoneal_inflammation2.05563956
18MP0004130_abnormal_muscle_cell1.91896847
19MP0003252_abnormal_bile_duct1.88073914
20MP0008260_abnormal_autophagy1.86093708
21MP0003828_pulmonary_edema1.80767677
22MP0002138_abnormal_hepatobiliary_system1.80317401
23MP0003191_abnormal_cellular_cholesterol1.79506751
24MP0009785_altered_susceptibility_to1.78972251
25MP0010329_abnormal_lipoprotein_level1.78574818
26MP0005000_abnormal_immune_tolerance1.77551896
27MP0003172_abnormal_lysosome_physiology1.74421450
28* MP0000609_abnormal_liver_physiology1.71727540
29MP0004510_myositis1.71383221
30* MP0002723_abnormal_immune_serum1.70643141
31MP0005464_abnormal_platelet_physiology1.69492027
32MP0005025_abnormal_response_to1.68618852
33MP0002132_abnormal_respiratory_system1.67187493
34MP0001873_stomach_inflammation1.67020011
35MP0004947_skin_inflammation1.65797537
36MP0004381_abnormal_hair_follicle1.65569361
37MP0010155_abnormal_intestine_physiology1.62460773
38MP0003724_increased_susceptibility_to1.61863166
39MP0002396_abnormal_hematopoietic_system1.61704984
40* MP0002398_abnormal_bone_marrow1.61339329
41MP0002452_abnormal_antigen_presenting1.61120191
42MP0001853_heart_inflammation1.59472655
43MP0008875_abnormal_xenobiotic_pharmacok1.59265496
44* MP0002420_abnormal_adaptive_immunity1.58348828
45MP0002837_dystrophic_cardiac_calcinosis1.56832560
46* MP0001819_abnormal_immune_cell1.56414633
47MP0005083_abnormal_biliary_tract1.53399298
48MP0002405_respiratory_system_inflammati1.49553324
49MP0008961_abnormal_basal_metabolism1.49286940
50MP0001851_eye_inflammation1.45965326
51* MP0000716_abnormal_immune_system1.44076240
52MP0003705_abnormal_hypodermis_morpholog1.43819185
53MP0002006_tumorigenesis1.43472545
54MP0003806_abnormal_nucleotide_metabolis1.41054621
55* MP0002419_abnormal_innate_immunity1.39435881
56MP0003866_abnormal_defecation1.38377269
57MP0009278_abnormal_bone_marrow1.38020150
58* MP0000689_abnormal_spleen_morphology1.37849238
59* MP0001845_abnormal_inflammatory_respons1.37382228
60* MP0002722_abnormal_immune_system1.36713356
61* MP0000703_abnormal_thymus_morphology1.34403881
62* MP0008469_abnormal_protein_level1.32626207
63MP0003656_abnormal_erythrocyte_physiolo1.32577580
64MP0006082_CNS_inflammation1.29924706
65MP0000858_altered_metastatic_potential1.26917527
66MP0004808_abnormal_hematopoietic_stem1.26364331
67MP0001666_abnormal_nutrient_absorption1.21861668
68* MP0002429_abnormal_blood_cell1.21505872
69MP0009333_abnormal_splenocyte_physiolog1.20402487
70MP0005397_hematopoietic_system_phenotyp1.20280077
71MP0001545_abnormal_hematopoietic_system1.20280077
72MP0005319_abnormal_enzyme/_coenzyme1.18691174
73MP0002998_abnormal_bone_remodeling1.18238334
74MP0005670_abnormal_white_adipose1.15114423
75MP0002933_joint_inflammation1.13146165
76MP0005666_abnormal_adipose_tissue1.13069357
77MP0003690_abnormal_glial_cell1.13028434
78MP0005584_abnormal_enzyme/coenzyme_acti1.12882065
79MP0004036_abnormal_muscle_relaxation1.11112382
80* MP0002118_abnormal_lipid_homeostasis1.10872841
81MP0004883_abnormal_blood_vessel1.10096895
82MP0002148_abnormal_hypersensitivity_rea1.08762234
83MP0002009_preneoplasia1.08417673
84MP0004185_abnormal_adipocyte_glucose1.07143799
85MP0005310_abnormal_salivary_gland1.06914569
86MP0001533_abnormal_skeleton_physiology1.04730152
87MP0009764_decreased_sensitivity_to1.04555380
88MP0002971_abnormal_brown_adipose1.02497525
89MP0000465_gastrointestinal_hemorrhage1.00840399
90MP0000747_muscle_weakness1.00208026
91MP0005332_abnormal_amino_acid0.99833494
92MP0003868_abnormal_feces_composition0.99694662
93MP0003646_muscle_fatigue0.99339302
94MP0009763_increased_sensitivity_to0.98498937
95* MP0000598_abnormal_liver_morphology0.97229688
96MP0003183_abnormal_peptide_metabolism0.95091351
97MP0005058_abnormal_lysosome_morphology0.94883990
98MP0002877_abnormal_melanocyte_morpholog0.94865141
99MP0004087_abnormal_muscle_fiber0.93177682
100MP0000751_myopathy0.90694387
101* MP0009643_abnormal_urine_homeostasis0.90599531
102MP0000749_muscle_degeneration0.90386294
103MP0010352_gastrointestinal_tract_polyps0.89945762
104MP0002269_muscular_atrophy0.89760526
105MP0004084_abnormal_cardiac_muscle0.88215847
106MP0003075_altered_response_to0.87996311
107MP0005375_adipose_tissue_phenotype0.87219991
108MP0003045_fibrosis0.86448331
109MP0008004_abnormal_stomach_pH0.84718745
110MP0001663_abnormal_digestive_system0.83842353
111MP0003221_abnormal_cardiomyocyte_apopto0.82408069
112MP0002277_abnormal_respiratory_mucosa0.80500504
113MP0005076_abnormal_cell_differentiation0.80355980
114MP0006036_abnormal_mitochondrial_physio0.80326654
115MP0003195_calcinosis0.80239258
116MP0005166_decreased_susceptibility_to0.80035332
117MP0000604_amyloidosis0.79870066
118MP0005330_cardiomyopathy0.79294699
119MP0005075_abnormal_melanosome_morpholog0.78711641
120MP0005164_abnormal_response_to0.78574256
121* MP0002078_abnormal_glucose_homeostasis0.78055421
122MP0010630_abnormal_cardiac_muscle0.77144776
123* MP0005334_abnormal_fat_pad0.76951241
124MP0000490_abnormal_crypts_of0.75607369
125MP0003448_altered_tumor_morphology0.74581235
126MP0009115_abnormal_fat_cell0.73638244
127MP0003091_abnormal_cell_migration0.71883019
128MP0005390_skeleton_phenotype0.67540730
129MP0000249_abnormal_blood_vessel0.65746317
130MP0008874_decreased_physiological_sensi0.65109298
131* MP0002019_abnormal_tumor_incidence0.63940030
132MP0003795_abnormal_bone_structure0.61678311
133MP0000015_abnormal_ear_pigmentation0.60218399
134MP0000343_altered_response_to0.56791224
135MP0008057_abnormal_DNA_replication0.56515111
136MP0009765_abnormal_xenobiotic_induced0.55346264
137MP0001348_abnormal_lacrimal_gland0.54873066
138MP0002332_abnormal_exercise_endurance0.54066837

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.76879227
2Recurrent bacterial skin infections (HP:0005406)4.70385380
3Orchitis (HP:0100796)4.57700878
4Optic neuritis (HP:0100653)4.30913832
5Retrobulbar optic neuritis (HP:0100654)4.30913832
6Abnormality of macrophages (HP:0004311)4.16372916
7Stomatitis (HP:0010280)3.89821463
8T lymphocytopenia (HP:0005403)3.70769478
9Deep venous thrombosis (HP:0002625)3.70214964
10Obstructive lung disease (HP:0006536)3.68075457
11Chronic obstructive pulmonary disease (HP:0006510)3.68075457
12Abnormality of T cell number (HP:0011839)3.54213739
13Mediastinal lymphadenopathy (HP:0100721)3.51873953
14Encephalitis (HP:0002383)3.44889931
15Keratoconjunctivitis sicca (HP:0001097)3.41865770
16Recurrent viral infections (HP:0004429)3.31860028
17Recurrent fungal infections (HP:0002841)3.16267753
18Vasculitis (HP:0002633)3.15257249
19Gingivitis (HP:0000230)3.13971232
20Exercise-induced myalgia (HP:0003738)3.09265274
21Keratoconjunctivitis (HP:0001096)3.07995416
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.03358477
23Chest pain (HP:0100749)3.02393422
24Panhypogammaglobulinemia (HP:0003139)3.01163003
25Xanthomatosis (HP:0000991)2.99086457
26Abnormality of the common coagulation pathway (HP:0010990)2.93378622
27Myoglobinuria (HP:0002913)2.92497275
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89334616
29Abnormality of T cells (HP:0002843)2.87534777
30Nasal polyposis (HP:0100582)2.82778285
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.80084577
32Chronic otitis media (HP:0000389)2.78178674
33Intrahepatic cholestasis (HP:0001406)2.76251874
34Exercise-induced muscle cramps (HP:0003710)2.75997446
35Complement deficiency (HP:0004431)2.75084650
36Urticaria (HP:0001025)2.74283996
37Eczematoid dermatitis (HP:0000976)2.73419413
38Abnormality of the nasal mucosa (HP:0000433)2.72551960
39Granulocytopenia (HP:0001913)2.72330354
40Elevated erythrocyte sedimentation rate (HP:0003565)2.70562721
41Hypochromic microcytic anemia (HP:0004840)2.70086967
42Hypoglycemic coma (HP:0001325)2.68035588
43Pulmonary infiltrates (HP:0002113)2.62491375
44Hemoptysis (HP:0002105)2.61861864
45Hypochromic anemia (HP:0001931)2.61038900
46Myocardial infarction (HP:0001658)2.60745053
47Spontaneous hematomas (HP:0007420)2.59014507
48Leukocytosis (HP:0001974)2.58826667
49Hyperlipoproteinemia (HP:0010980)2.58573658
50Gingival bleeding (HP:0000225)2.57354017
51Ketosis (HP:0001946)2.57278512
52Gastrointestinal inflammation (HP:0004386)2.50475184
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49547075
54Joint hemorrhage (HP:0005261)2.49481698
55Inflammation of the large intestine (HP:0002037)2.48434326
56Osteomyelitis (HP:0002754)2.46637132
57Chronic mucocutaneous candidiasis (HP:0002728)2.46594496
58Recurrent cutaneous fungal infections (HP:0011370)2.46594496
59Episodic fever (HP:0001954)2.45859643
60IgM deficiency (HP:0002850)2.44414108
61Recurrent bronchitis (HP:0002837)2.43108147
62Agammaglobulinemia (HP:0004432)2.42919205
63Prolonged partial thromboplastin time (HP:0003645)2.42635789
64Colitis (HP:0002583)2.42179161
65Lymphopenia (HP:0001888)2.41468218
66Slow saccadic eye movements (HP:0000514)2.40011666
67Epistaxis (HP:0000421)2.39387298
68Ketoacidosis (HP:0001993)2.33267212
69Abnormality of the fingertips (HP:0001211)2.30222819
70Recurrent gram-negative bacterial infections (HP:0005420)2.29983064
71Hyporeflexia of lower limbs (HP:0002600)2.29831601
72Hypobetalipoproteinemia (HP:0003563)2.28672572
73Abnormality of T cell physiology (HP:0011840)2.28303104
74Rhabdomyolysis (HP:0003201)2.27887113
75Polycythemia (HP:0001901)2.27799611
76Increased IgM level (HP:0003496)2.26545717
77Abnormality of cells of the lymphoid lineage (HP:0012140)2.26414617
78Peritonitis (HP:0002586)2.26352752
79Viral hepatitis (HP:0006562)2.25925317
80Asymmetric septal hypertrophy (HP:0001670)2.25359079
81Autoimmune hemolytic anemia (HP:0001890)2.24356027
82Verrucae (HP:0200043)2.23612239
83Papilloma (HP:0012740)2.23612239
84Microcytic anemia (HP:0001935)2.23446521
85Ulnar deviation of the wrist (HP:0003049)2.22473135
86Muscle fiber inclusion bodies (HP:0100299)2.22210735
87Abnormal platelet volume (HP:0011876)2.22185304
88Hypoplasia of the thymus (HP:0000778)2.21286526
89Abnormality of the peritoneum (HP:0002585)2.20357110
90Increased density of long bones (HP:0006392)2.20177268
91Hyperammonemia (HP:0001987)2.17911613
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.17606172
93Impaired platelet aggregation (HP:0003540)2.17505474
94Abnormal platelet function (HP:0011869)2.17505474
95Gastrointestinal infarctions (HP:0005244)2.15902906
96B lymphocytopenia (HP:0010976)2.15067834
97Abnormality of B cell number (HP:0010975)2.15067834
98Anorexia (HP:0002039)2.14641200
99Frequent falls (HP:0002359)2.14034908
100Prolonged bleeding time (HP:0003010)2.13721842
101Metaphyseal cupping (HP:0003021)2.13529286
102Hypoalphalipoproteinemia (HP:0003233)2.11674961
103Abnormality of fatty-acid metabolism (HP:0004359)2.11443626
104Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11431292
105Autoimmune thrombocytopenia (HP:0001973)2.10435478
106Menorrhagia (HP:0000132)2.10100916
107Joint swelling (HP:0001386)2.09508085
108Gastrointestinal stroma tumor (HP:0100723)2.09018812
109Fatigue (HP:0012378)2.08662730
110Myositis (HP:0100614)2.07931825
111Sepsis (HP:0100806)2.06943154
112Petechiae (HP:0000967)2.06496771
113Abnormality of complement system (HP:0005339)2.05062077
114Hypolipoproteinemia (HP:0010981)2.05017868
115Late onset (HP:0003584)2.03723521
116Increased mean platelet volume (HP:0011877)2.03691779
117Pulmonary embolism (HP:0002204)2.02435180
118Segmental peripheral demyelination/remyelination (HP:0003481)2.02258469
119Abnormality of the endocardium (HP:0004306)2.02228905
120Abnormality of the pleura (HP:0002103)2.02168476
121Severe combined immunodeficiency (HP:0004430)2.01907814
122Type 1 muscle fiber predominance (HP:0003803)2.01782447
123Recurrent skin infections (HP:0001581)2.00357129
124Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.00264617
125Abnormality of the intrinsic pathway (HP:0010989)2.00082455
126Combined immunodeficiency (HP:0005387)2.00066168
127Esophageal varix (HP:0002040)1.99090911
128Cholelithiasis (HP:0001081)1.98905973
129Papilledema (HP:0001085)1.98736920
130Increased connective tissue (HP:0009025)1.97452188
131Abnormality of the heme biosynthetic pathway (HP:0010472)1.96658193
132Mitral stenosis (HP:0001718)1.96350488
133Hypergammaglobulinemia (HP:0010702)1.93285891
134Difficulty running (HP:0009046)1.92586441
135Hyperbilirubinemia (HP:0002904)1.92221546
136Acute hepatic failure (HP:0006554)1.91448523
137Acne (HP:0001061)1.90813045
138Eosinophilia (HP:0001880)1.90618291
139Skin ulcer (HP:0200042)1.90567125
140Arterial thrombosis (HP:0004420)1.90458283
141Increased IgE level (HP:0003212)1.89508489
142Chronic diarrhea (HP:0002028)1.89418788
143Thrombocytosis (HP:0001894)1.88775044
144Meningitis (HP:0001287)1.87914692
145Abnormal gallbladder morphology (HP:0012437)1.86830844
146Pustule (HP:0200039)1.86695489
147Abnormality of the left ventricular outflow tract (HP:0011103)1.86420697
148Subaortic stenosis (HP:0001682)1.86420697
149Calf muscle hypertrophy (HP:0008981)1.85912946
150Cellulitis (HP:0100658)1.85227358
151Subacute progressive viral hepatitis (HP:0006572)1.85103843
152Cerebral aneurysm (HP:0004944)1.84814047
153Glomerulopathy (HP:0100820)1.83581465
154Gangrene (HP:0100758)1.81429248
155Amyloidosis (HP:0011034)1.79071331
156Purpura (HP:0000979)1.77538892
157Hypertensive crisis (HP:0100735)1.77023084
158Vertigo (HP:0002321)1.74992973
159Aplasia/Hypoplasia of the thymus (HP:0010515)1.74565047
160Centrally nucleated skeletal muscle fibers (HP:0003687)1.73856626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.60299435
2MAP4K14.06798412
3TRIB33.64583183
4PRPF4B3.42054850
5EEF2K3.09144956
6PKN23.08681560
7FGFR42.92244590
8JAK32.67383411
9ERN12.50449927
10TTN2.49733340
11MAP3K102.36656424
12TXK2.21937566
13SIK12.18132805
14TAOK32.08265258
15ZAP702.07889605
16ITK2.07162394
17JAK11.93207643
18MAP2K31.85261579
19KSR21.83560906
20EPHB11.82001287
21TBK11.81150027
22FLT31.67412721
23FGFR31.63627385
24GRK61.62343127
25MAP3K141.61482470
26IKBKE1.61301442
27MAP3K71.60615220
28STK101.58522272
29BCKDK1.51716896
30* TYK21.51631992
31BTK1.51530159
32LRRK21.35383306
33SMG11.25759467
34TGFBR21.23671542
35KIT1.23561116
36EPHA31.22886546
37CSK1.22466898
38MARK21.20261990
39* JAK21.19480635
40TEC1.18628811
41SYK1.13913307
42NLK1.13123403
43LCK1.09058346
44MAP3K131.08492460
45FGR1.05360055
46RIPK11.05150787
47YES11.00487625
48PIK3CG0.99231762
49CSF1R0.99072274
50KDR0.96916781
51PRKCH0.94539375
52OBSCN0.93335053
53* HCK0.93236944
54IRAK10.89125474
55CAMK1D0.88280725
56SIK30.87132035
57TAOK20.86373207
58IKBKB0.85951462
59MAP3K60.85366483
60* PTK60.83861711
61HIPK20.83720150
62RAF10.81166134
63MAP3K20.80499149
64BMPR20.79965416
65MAPK110.79230083
66NEK90.78946723
67BLK0.78399639
68SIK20.78136224
69RET0.77633928
70CHUK0.75539357
71MAPK120.73827574
72PDPK10.73793248
73CAMK1G0.73695465
74CDC42BPA0.72360817
75DMPK0.71964980
76RPS6KA40.69784835
77PIM10.69520688
78TAOK10.69498123
79IRAK30.67949839
80MAPK70.66668858
81SCYL20.65984642
82PRKAA20.65891409
83CDK40.65297054
84MARK30.64841363
85WNK10.64485075
86PRKCQ0.64070119
87PRKD20.63965780
88CDK120.63619879
89CAMKK10.62954019
90IRAK20.62930755
91ICK0.61418824
92INSRR0.60344444
93MATK0.59822014
94MAP3K10.59695514
95KSR10.58978694
96MAPKAPK30.58693316
97MAP3K30.58617579
98RPS6KL10.58135005
99RPS6KC10.58135005
100MAP3K110.57262987
101PDK10.56438653
102CDK60.56306594
103FYN0.56245492
104TNK20.55552699
105PDGFRB0.55041280
106SGK20.53395100
107PDGFRA0.52372441
108ALK0.52094164
109IRAK40.51470542
110SGK30.50935203
111TRPM70.50464182
112MAPK40.49936342
113STK110.49265130
114FES0.49043167
115BMX0.48697841
116BRD40.47252406
117MTOR0.45381028
118NME20.45109755
119STK40.42930276
120PHKG20.42848971
121PHKG10.42848971
122LYN0.41543430
123CDK190.40041646
124PRKD10.39434691
125TYRO30.39373205
126RPS6KB20.39236925
127MAP2K40.38859362
128DYRK1B0.33917996
129PRKAA10.32212757
130CDK90.31330521
131RPS6KA60.30312830
132TGFBR10.30218701
133CLK10.29744380
134MAP3K80.28727920

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.51249383
2Primary immunodeficiency_Homo sapiens_hsa053402.92229806
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.74600501
4Nitrogen metabolism_Homo sapiens_hsa009102.46377808
5Arginine biosynthesis_Homo sapiens_hsa002202.20332194
6Staphylococcus aureus infection_Homo sapiens_hsa051502.16437127
7Fatty acid degradation_Homo sapiens_hsa000712.13985060
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.94423560
9Complement and coagulation cascades_Homo sapiens_hsa046101.89601623
10Graft-versus-host disease_Homo sapiens_hsa053321.86190713
11T cell receptor signaling pathway_Homo sapiens_hsa046601.83301227
12Autoimmune thyroid disease_Homo sapiens_hsa053201.82194388
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78244802
14Tryptophan metabolism_Homo sapiens_hsa003801.78156988
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74118219
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58527617
17Osteoclast differentiation_Homo sapiens_hsa043801.58338211
18Caffeine metabolism_Homo sapiens_hsa002321.56763966
19Malaria_Homo sapiens_hsa051441.55971074
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.55012649
21Propanoate metabolism_Homo sapiens_hsa006401.53700440
22B cell receptor signaling pathway_Homo sapiens_hsa046621.52181311
23Insulin resistance_Homo sapiens_hsa049311.51460585
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50685182
25PPAR signaling pathway_Homo sapiens_hsa033201.48814262
26ABC transporters_Homo sapiens_hsa020101.48183571
27Leishmaniasis_Homo sapiens_hsa051401.45331270
28* Measles_Homo sapiens_hsa051621.43178679
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.41086141
30Lysine degradation_Homo sapiens_hsa003101.36847044
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32545018
32Fatty acid metabolism_Homo sapiens_hsa012121.30765656
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.27810297
34Type I diabetes mellitus_Homo sapiens_hsa049401.23675350
35Antigen processing and presentation_Homo sapiens_hsa046121.22781429
36Renal cell carcinoma_Homo sapiens_hsa052111.21194107
37* Acute myeloid leukemia_Homo sapiens_hsa052211.20577806
38Starch and sucrose metabolism_Homo sapiens_hsa005001.16571735
39Toxoplasmosis_Homo sapiens_hsa051451.11998187
40* Jak-STAT signaling pathway_Homo sapiens_hsa046301.11315389
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.09889841
42Endometrial cancer_Homo sapiens_hsa052131.08653722
43Other glycan degradation_Homo sapiens_hsa005111.08532776
44Selenocompound metabolism_Homo sapiens_hsa004501.06970013
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06049144
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05901674
47Carbon metabolism_Homo sapiens_hsa012001.05771185
48Peroxisome_Homo sapiens_hsa041461.02757534
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01550486
50Viral myocarditis_Homo sapiens_hsa054160.98657512
51African trypanosomiasis_Homo sapiens_hsa051430.97681868
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96934257
53Notch signaling pathway_Homo sapiens_hsa043300.95778317
54Hematopoietic cell lineage_Homo sapiens_hsa046400.95243444
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94729518
56Bile secretion_Homo sapiens_hsa049760.93989748
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.92108326
58Choline metabolism in cancer_Homo sapiens_hsa052310.92041351
59Colorectal cancer_Homo sapiens_hsa052100.91862069
60beta-Alanine metabolism_Homo sapiens_hsa004100.91297270
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88709725
62* Chronic myeloid leukemia_Homo sapiens_hsa052200.88523547
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86762532
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86584589
65GnRH signaling pathway_Homo sapiens_hsa049120.86545357
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86429915
67Biosynthesis of amino acids_Homo sapiens_hsa012300.83558409
68Platelet activation_Homo sapiens_hsa046110.83391037
69Pyruvate metabolism_Homo sapiens_hsa006200.83370234
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83309881
71Inositol phosphate metabolism_Homo sapiens_hsa005620.82747948
72Butanoate metabolism_Homo sapiens_hsa006500.82600667
73Sulfur relay system_Homo sapiens_hsa041220.82242150
74Shigellosis_Homo sapiens_hsa051310.79669123
75* Viral carcinogenesis_Homo sapiens_hsa052030.79621982
76Asthma_Homo sapiens_hsa053100.79278960
77Dorso-ventral axis formation_Homo sapiens_hsa043200.78928081
78Insulin signaling pathway_Homo sapiens_hsa049100.78470461
79TNF signaling pathway_Homo sapiens_hsa046680.77924580
80HIF-1 signaling pathway_Homo sapiens_hsa040660.77672414
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.75994697
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.75106440
83Phagosome_Homo sapiens_hsa041450.74479911
84* HTLV-I infection_Homo sapiens_hsa051660.74286345
85Glioma_Homo sapiens_hsa052140.73843641
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72718327
87* Prolactin signaling pathway_Homo sapiens_hsa049170.72057170
88Legionellosis_Homo sapiens_hsa051340.71653797
89Epstein-Barr virus infection_Homo sapiens_hsa051690.71438195
90Phenylalanine metabolism_Homo sapiens_hsa003600.71287463
91Influenza A_Homo sapiens_hsa051640.70528592
92Long-term potentiation_Homo sapiens_hsa047200.70339102
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70321360
94Pentose phosphate pathway_Homo sapiens_hsa000300.69831955
95Prostate cancer_Homo sapiens_hsa052150.69541913
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69068350
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.68540768
98Thyroid cancer_Homo sapiens_hsa052160.68103941
99* ErbB signaling pathway_Homo sapiens_hsa040120.68069996
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67842646
101Herpes simplex infection_Homo sapiens_hsa051680.67770391
102Pancreatic cancer_Homo sapiens_hsa052120.65188212
103* Hepatitis B_Homo sapiens_hsa051610.64929011
104Histidine metabolism_Homo sapiens_hsa003400.64497651
105MAPK signaling pathway_Homo sapiens_hsa040100.64116367
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63895202
107* Chemokine signaling pathway_Homo sapiens_hsa040620.63687197
108Endocytosis_Homo sapiens_hsa041440.62861850
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61801016
110AMPK signaling pathway_Homo sapiens_hsa041520.61452733
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61064871
112Apoptosis_Homo sapiens_hsa042100.60040206
113Type II diabetes mellitus_Homo sapiens_hsa049300.58998223
114Salmonella infection_Homo sapiens_hsa051320.58741350
115Amoebiasis_Homo sapiens_hsa051460.58000585
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.55672824
117Glucagon signaling pathway_Homo sapiens_hsa049220.55663058
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55483472
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55192233
120Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55163836
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54597614
122Estrogen signaling pathway_Homo sapiens_hsa049150.54591601
123Hepatitis C_Homo sapiens_hsa051600.54174174
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53669182
125Non-small cell lung cancer_Homo sapiens_hsa052230.53100525
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.51283895
127Fat digestion and absorption_Homo sapiens_hsa049750.51066219
128Glycerolipid metabolism_Homo sapiens_hsa005610.50855843
129Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50431781
130Pertussis_Homo sapiens_hsa051330.50337878
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50209097
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.49393293
133mTOR signaling pathway_Homo sapiens_hsa041500.49371560
134* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49039328
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48333418
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.47978010
137Allograft rejection_Homo sapiens_hsa053300.47282724
138Rap1 signaling pathway_Homo sapiens_hsa040150.47046308
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46766667
140Tuberculosis_Homo sapiens_hsa051520.43940345
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.43138388
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42811348
143FoxO signaling pathway_Homo sapiens_hsa040680.42164418
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.42120828
145VEGF signaling pathway_Homo sapiens_hsa043700.41816902
146Galactose metabolism_Homo sapiens_hsa000520.41793983
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40179752

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »